Traditional Chinese medicine composition and traditional Chinese medicine lozenge for treating hemodialysis thirst and preparation method of traditional Chinese medicine composition and traditional Chinese medicine lozenge

Abstract

The invention discloses a traditional Chinese medicine composition for treating hemodialysis thirst, a traditional Chinese medicine lozenge and a preparation method. The composition is prepared from the following raw materials in parts by weight: 10-20 parts of American ginseng, 10-20 parts of radix glehniae, 8-12 parts of radix scrophulariae, 8-12 parts of fructus mume, 8-12 parts of mulberry, 8-12 parts of radix angelicae, 8-12 parts of radix paeoniae alba, 4-6 parts of mint, 8-12 parts of purple perilla and 8-12 parts of liquorice. Meanwhile, the invention discloses a traditional Chinese medicine lozenge containing the composition, the traditional Chinese medicine composition for treating the hemodialysis thirst is prepared by adding an adhesive, a lubricant, a flavoring agent and a filling agent into the traditional Chinese medicine composition, the traditional Chinese medicine composition is compatible and prepared into the lozenge which is easily accepted by patients, and the traditional Chinese medicine lozenge can be used for treating and relieving the hemodialysis thirst. The technical problems in the prior art are solved.

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating thirst during hemodialysis, a Chinese medicine lozenge and a preparation method. Background Art

[0002] Epidemiological surveys in 2022 showed that the total prevalence of chronic kidney disease in the adult population in China was 10.8%, or about 112.5 million people. Currently, there are more than 4 million patients with end-stage renal disease, and there will be about 80,000 new patients entering hemodialysis in 2023. Maintenance hemodialysis (MHD) treatment plays an irreplaceable role in maintaining the lives of patients with end-stage renal disease, but it cannot truly realize the endocrine function of the kidneys and the renal tubular reabsorption function. Therefore, MHD patients still have a variety of complications and discomfort symptoms, some of which seriously affect the quality of life of patients. According to relevant domestic and foreign literature reports, the prevalence of thirst in the general population is 10%-46%, and it continues to increase with age, while the prevalence of thirst in hemodialysis patients has risen to 68%-86%. Martine et al. found that about 30% of hemodialysis patients may experience severe thirst symptoms. It far exceeds the incidence of skin itching, restless legs syndrome, insomnia and other syndromes. The vast majority of long-term hemodialysis patients are in a state of oliguria or anuria. Drinking too much water will lead to an increase in the body's circulating volume, increase the cardiovascular burden, and cause complications such as edema, hypertension, and heart failure, which will affect the adequacy of dialysis and significantly increase the patient's average hospitalization rate, and significantly increase the patient's cardiovascular and cerebrovascular complications and the risk of disability and death.

[0003] At present, modern medicine has not found effective drugs and methods for intervention and treatment. It mainly relies on medical staff to educate on diet, divert attention, gargle with ice cubes, chew gum, use saliva substitutes, adjust dialysis methods, etc. There is no recognized effective treatment measure. Therefore, controlling the fluid intake of patients with uremia and relieving thirst symptoms have become difficult problems that clinicians often face.

[0004] Traditional Chinese medicine has a long history of understanding thirst, and it is generally believed that its main pathogenesis is insufficient body fluid due to exogenous evil or deficiency of the body's body. Due to short-term ultrafiltration dehydration, hemodialysis patients lose protein and other fine substances while removing toxins from the body, resulting in yin and body fluid depletion, qi loss with body fluid, qi failure to transform body fluid, and body fluid damage and dryness. At the same time, hemodialysis patients suffer from end-stage renal failure caused by various kidney diseases, which is a deficiency of the root and excess of the symptoms. The root deficiency is spleen and kidney deficiency, and dampness, heat and aging are the excess symptoms. Patients have spleen deficiency and body fluid is not produced, and body fluid is lost due to dialysis, so they have clinical manifestations such as thirst and dry skin. The rational use of principles, methods, prescriptions and medicines under the guidance of thousands of years of traditional Chinese medicine theory has a unique therapeutic effect on some diseases.

[0005] Existing patent CN113230327A discloses a Chinese medicine preparation for relieving thirst in hemodialysis patients and its preparation method, which increases local stimulation to the salivary glands in the oral cavity and relieves symptoms; CN114588209A discloses tangerine peel and lemon extract and its use in the preparation of drugs for treating salivary gland diseases, which increases salivary gland secretion and improves the patient's subjective feeling of thirst; both relieve thirst to a certain extent; based on many years of clinical experience in traditional Chinese medicine and under the guidance of the traditional Chinese medicine theory of "acid and sweet transform yin", the applicant analyzes the etiology and pathogenesis of thirst in maintenance hemodialysis patients. On the one hand, it is necessary to consider the efficacy of the Chinese medicine composition and on the other hand, it is necessary to consider the convenience of practical application. Therefore, the applicant proposes a Chinese medicine composition, Chinese medicine lozenges and preparation method for treating hemodialysis thirst. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine composition, a Chinese medicine lozenge and a preparation method for treating thirst in hemodialysis patients. The Chinese medicine composition is prepared into lozenges that are easy for patients to accept and take, thereby treating and relieving thirst in hemodialysis patients and solving the technical problems existing in the prior art.

[0007] In order to achieve the above technical objectives and the above technical effects, the present invention is implemented through the following technical solutions:

[0008] A traditional Chinese medicine composition for treating thirst during hemodialysis comprises the following raw materials in parts by weight: 10-20 parts of American ginseng, 10-20 parts of northern adenophora, 8-12 parts of Scrophularia, 8-12 parts of black plum, 8-12 parts of mulberry, 8-12 parts of angelica dahurica, 8-12 parts of white peony root, 4-6 parts of mint, 8-12 parts of perilla, and 8-12 parts of liquorice.

[0009] Furthermore, the Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of American ginseng, 15 parts of northern adenophora, 10 parts of Scrophularia, 10 parts of black plum, 10 parts of mulberry, 10 parts of Angelica dahurica, 10 parts of white peony root, 5 parts of mint, 10 parts of Perilla frutescens, and 10 parts of licorice.

[0010] The Chinese medicine composition for treating thirst during hemodialysis of the present invention uses raw materials with the following effects:

[0011] American ginseng: Nature and flavor: sweet, slightly bitter, cool. Meridians: heart, lung, and kidney meridians.

[0012] Efficacy: replenishes qi and nourishes yin, clears away heat and produces body fluid. It is suitable for the syndrome of qi and yin deficiency, shortness of breath, cough with little sputum, or blood in sputum caused by heat damaging the qi and yin of the lung. It can also replenish the heart qi and nourish the heart yin, and can be used for palpitations, heartache, insomnia and dreaminess caused by deficiency of both qi and yin of the heart. It is also suitable for fever, sweating, thirst, irritability, fatigue, shortness of breath, and weak pulse caused by heat damaging qi and body fluid.

[0013] Radix Adenophorae: Nature and flavor: sweet, slightly bitter, slightly cold. Meridians: enter the lung and stomach meridians.

[0014] Efficacy: It nourishes yin and clears the lungs, benefits the stomach and produces fluid. It is used for dry cough with little sputum, hemoptysis or dry throat and hoarseness due to yin deficiency and lung dryness with heat. It replenishes stomach yin, produces fluid and quenches thirst, and can also clear stomach heat. It is used for dry mouth, frequent drinking, lack of appetite, and dry stool due to stomach yin deficiency and heat.

[0015] Scrophularia: Nature and flavor: cold, sweet, bitter, salty. Meridians: lung, stomach, kidney meridians.

[0016] Efficacy: sweet and cold nourishes yin, bitter and cold purges fire, salty and cold enters the blood. Used for dry cough due to lung dryness, fever and thirst, red tongue and thirst, sore throat, loss of body fluid and thirst, dry intestine and constipation, etc.

[0017] Wumei: Nature and flavor: sour, astringent, neutral. Meridians: liver, spleen, lung, large intestine meridians.

[0018] Efficacy: It has the effects of astringing the lungs, astringing the intestines, promoting the production of body fluids, and calming ascaris. It is often used for chronic cough due to lung deficiency, chronic diarrhea and dysentery, deficiency heat and thirst, ascariasis, vomiting and abdominal pain.

[0019] Mulberry: Nature and flavor: sweet, sour, cold. Meridians: enter the liver and kidney meridians.

[0020] Efficacy: It nourishes yin and blood, promotes the production of body fluid and moistens dryness. It is used for liver and kidney yin deficiency, dizziness and tinnitus, palpitations and insomnia, premature graying of hair, thirst due to loss of body fluid, internal heat and thirst, dry intestines and constipation, etc.

[0021] Angelica dahurica: Nature and flavor: spicy, warm. Meridians: lung, spleen, stomach meridians.

[0022] Efficacy: It has the effects of dispelling cold, dispelling wind and relieving pain, clearing the nasal passages, drying dampness and stopping leukorrhea, reducing swelling and discharging pus. It is used for colds, headaches, toothaches, rheumatic pain, sinusitis, nasal congestion and runny nose, leukorrhea, and sores, carbuncles, swelling and poison, etc.

[0023] White Peony Root: Nature and flavor: bitter, sour, slightly cold. Meridians: liver and spleen meridians.

[0024] Efficacy: It nourishes blood and regulates menstruation, restrains yin and stops sweating, softens the liver and stops pain, and suppresses liver yang. It is used for blood deficiency, sallow menstruation, dysmenorrhea, metrorrhagia, etc.; blood deficiency syndrome and liver yin deficiency, cramps and pain in the ribs, abdomen, and limbs, and liver yang hyperactivity, dizziness and headache; it is also commonly used for spontaneous sweating and night sweats.

[0025] Mint: Nature and flavor: spicy and cool. Meridians: enter the lung and liver meridians.

[0026] Efficacy: It has the effects of dispersing wind-heat, clearing the head and eyes, relieving sore throat and rash, and soothing the liver and promoting qi. It is mainly used to treat symptoms such as headache, red eyes, sore throat, mouth sores, rubella, measles, and chest and flank distension caused by wind-heat cold.

[0027] Perilla: Nature and flavor: spicy and warm. Meridians: enter the lung and spleen meridians.

[0028] It has the effects of dispelling cold, promoting qi and harmonizing the stomach. It is mainly used to treat colds, coughs, asthma, vomiting during pregnancy, and restless fetuses; it can also detoxify fish and crabs.

[0029] Licorice: Nature and flavor: sweet and neutral in nature. It enters the heart, lung, spleen and stomach meridians.

[0030] It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving urgency and relieving pain, and harmonizing various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and poison, and harmonizing various medicines.

[0031] The Chinese medicine composition for treating thirst during hemodialysis of the present invention comprises 10-20 parts of American ginseng, 10-20 parts of northern adenophora, 8-12 parts of Scrophularia, 8-12 parts of black plum, 8-12 parts of mulberry, 8-12 parts of angelica dahurica, 8-12 parts of white peony root, 4-6 parts of mint, 8-12 parts of perilla and 8-12 parts of liquorice.

[0032] In the formula, American ginseng, Adenophora adenophora, and Scrophularia ningpoensis are the main drugs, which are sweet and cold (cool) in nature, and have the effects of invigorating qi and nourishing yin, clearing heat and moistening dryness; black plum and mulberry are sour and sweet in nature, and have the effects of promoting fluid and quenching thirst, and are the ministerial drugs that can strengthen the main drug's effect of nourishing yin and promoting fluid; white peony nourishes blood and regulates menstruation, restrains yin and softens the liver, and mint has the effects of clearing heat and detoxifying, relieving sore throat and clearing throat, and is an adjuvant drug; angelica dahurica and perilla are pungent and warm in nature, and can regulate qi and harmonize the stomach, dispel wind and open the orifices, and can prevent the formula from being too cold, and are the counter-adjuvant drugs; licorice is sweet and flat in nature, and can invigorate the spleen and invigorate qi, and can reconcile various drugs as the guiding drug. The whole formula combines cold and warm, and the medicinal properties are mild, and it is both eliminating and tonifying, and has the effects of invigorating qi and nourishing yin, promoting fluid and quenching thirst, and clearing heat and relieving sore throat.

[0033] Another object of the present invention is to disclose a product for treating thirst during hemodialysis, the product comprising the above-mentioned Chinese medicine composition for treating thirst during hemodialysis and medically acceptable excipients;

[0034] The products include but are not limited to lozenges and oral sprays.

[0035] Another object of the present invention is to provide a Chinese medicine lozenge for treating thirst during hemodialysis.

[0036] The Chinese medicine lozenge for treating thirst during hemodialysis comprises the following raw materials in parts by weight: 50-70% of the Chinese medicine composition for treating thirst during hemodialysis, 5-15% of a binder, 1-5% of a lubricant, 1-5% of a flavoring agent, and the rest being a filler.

[0037] Furthermore, the Chinese medicine lozenge for treating thirst during hemodialysis comprises the following raw materials in parts by weight: 50% of the Chinese medicine composition for treating thirst during hemodialysis, 10% of a binder, 3% of a lubricant, 2% of a flavoring agent, and the rest being a filler;

[0038] Furthermore, the filler is microcrystalline cellulose, lactose or mannitol, which increases the volume of the lozenge and makes it easier to shape;

[0039] The binder is PVP, HPMC or gum arabic, which makes the raw materials and fillers bond together better;

[0040] The lubricant is magnesium stearate or talc, which reduces the friction between the lozenge and the mold, making it easier to demold the lozenge;

[0041] The flavoring agent is stevioside, citric acid or peppermint oil, which can mask the bitterness of the raw materials and enhance the taste. Different flavoring agents can be selected to adjust the taste.

[0042] Another object of the present invention is to provide a method for preparing a Chinese medicine lozenge for treating thirst during hemodialysis, the method comprising:

[0043] S1: Select American ginseng, Glehnia littoralis, Scrophularia ningpoensis, Prunus mume, Mulberry, Angelica dahurica, White peony root, Mentha arvense, Perilla frutescens, and Licorice according to the mass ratio, grind them into fine powder, mix them, and pass through a 100-mesh sieve for later use;

[0044] S2: Select auxiliary materials according to needs, and mix fillers, adhesives, flavoring agents, and lubricants in proportion;

[0045] S3: the Chinese medicine composition powder mixed in S1 and the auxiliary materials mixed in S2 are mixed and stirred evenly, and an appropriate amount of water or ethanol is added to form a soft material;

[0046] S4: sieving the soft material prepared in S3 to make granules, and then drying; adding a lubricant after drying, mixing the granules evenly, and then tableting to prepare Chinese medicine lozenges for treating thirst during hemodialysis.

[0047] Furthermore, the powder of the Chinese medicine composition is mixed with auxiliary materials to ensure uniform distribution of the components; wet granulation or dry granulation is used for granulation, the dried granules are sized, unqualified granules are removed, and a lubricant is added for mixing to ensure fluidity during tableting;

[0048] At the same time, after granulation, the tablets are placed in a tablet press for tableting to obtain lozenges of desired shape and thickness; during tableting, attention should be paid to controlling parameters such as pressure, speed and temperature to ensure the quality and stability of the lozenges.

[0049] The beneficial effects of the present invention are:

[0050] Compared with the prior art, the Chinese medicine composition for treating thirst during hemodialysis of the present invention is formulated based on traditional Chinese medicine theory and combined with the applicant's continuous summary of clinical experience for more than ten years. The whole formula combines cold and warm, has a mild nature, and has both eliminating and tonifying effects. It has the effects of invigorating qi and nourishing yin, promoting body fluid and quenching thirst, and clearing away heat and relieving sore throat. The Chinese medicine involved is a common medicinal material, without precious and scarce drugs, and has a mild nature, is safe and effective, and has no toxic side effects.

[0051] The present invention discloses a Chinese medicine lozenge for treating hemodialysis thirst syndrome by assisting with medically acceptable auxiliary materials, which can significantly improve the thirst symptom of maintenance hemodialysis patients, stimulate the saliva secretion of the patients' oral cavity, reduce the frequency and amount of water drinking of the patients, reduce the ultrafiltration volume of dialysis, improve the quality of life of the patients, and reduce the complications and hospitalization rate of the patients.

[0052] Of course, any product implementing the present invention does not necessarily need to achieve all of the advantages described above at the same time. DETAILED DESCRIPTION

[0053] In order to more clearly illustrate the technical solution of the embodiments of the present invention, the present invention will be described in detail below through embodiments.

[0054] Example 1

[0055] In this embodiment, the Chinese medicine composition for treating thirst during hemodialysis comprises: 15g of American ginseng, 15g of Adenophora dahurica, 10g of Scrophularia ningpoensis, 10g of Prunus mume, 10g of mulberry, 10g of Angelica dahurica, 10g of White Peony Root, 5g of Mint, 10g of Perilla frutescens, and 10g of Licorice.

[0056] Example 3

[0057] In this embodiment, the Chinese medicine lozenge for treating thirst during hemodialysis comprises the following raw materials in parts by weight: 50% of the Chinese medicine composition for treating thirst during hemodialysis, 10% of a binder, 3% of a lubricant, 2% of a flavoring agent, and the rest of the filler;

[0058] The filler is microcrystalline cellulose, lactose or mannitol, which increases the volume of the lozenge and makes it easier to shape;

[0059] The binder is PVP, HPMC or gum arabic, which makes the raw materials and fillers bond together better;

[0060] The lubricant is magnesium stearate or talc, which reduces the friction between the lozenge and the mold, making it easier to demold the lozenge;

[0061] The flavoring agent is stevioside, citric acid or peppermint oil, which can mask the bitterness of the raw materials and enhance the taste. Different flavoring agents can be selected to adjust the taste.

[0062] Example 4

[0063] In this embodiment, a method for preparing a Chinese medicine lozenge for treating thirst during hemodialysis is provided, the preparation method comprising:

[0064] S1: Select American ginseng, Glehnia littoralis, Scrophularia ningpoensis, Prunus mume, Mulberry, Angelica dahurica, White peony root, Mentha arvense, Perilla frutescens, and Licorice according to the mass ratio, grind them into fine powder, mix them, and pass through a 100-mesh sieve for later use;

[0065] S2: Select auxiliary materials according to needs, and mix fillers, adhesives, flavoring agents, and lubricants in proportion;

[0066] S3: the Chinese medicine composition powder mixed in S1 and the auxiliary materials mixed in S2 are mixed and stirred evenly, and an appropriate amount of water or ethanol is added to form a soft material;

[0067] S4: sieving the soft material prepared in S3 to make granules, and then drying; adding a lubricant after drying, mixing the granules evenly, and then tableting to prepare Chinese medicine lozenges for treating thirst during hemodialysis.

[0068] The powder of the Chinese medicine composition is mixed with auxiliary materials to ensure uniform distribution of the components; wet granulation or dry granulation is adopted for granulation, the dried granules are sized to remove unqualified granules, and a lubricant is added for mixing to ensure fluidity during tableting;

[0069] At the same time, after granulation, the tablets are placed in a tablet press for tableting to obtain lozenges of desired shape and thickness; during tableting, attention should be paid to controlling parameters such as pressure, speed and temperature to ensure the quality and stability of the lozenges.

[0070] Example 5

[0071] In this embodiment:

[0072] A total of 60 patients with maintenance hemodialysis who had thirst in the hemodialysis room were selected and randomly divided into a control group and a treatment group by tossing a coin, with 30 cases in each group. Both groups were treated with conventional Western medicine. Patients in the control group drank water to relieve thirst, while patients in the treatment group took the decoction of the Chinese medicine composition instead of water when thirsty, and were observed for 4 weeks. The dry mouth intensity scores (XQ) and resting saliva flow rate (UWS) of the two groups of subjects were collected and compared. Results: Before treatment, there was no statistically significant difference in the baseline data and dry mouth intensity scores between the treatment group and the control group (P>0.05). After treatment, the score of dry mouth intensity showed that the score of the treatment group (21.8±2.5) was significantly different from that before treatment (34.5±3.2) (P<0.01), and it was more effective in reducing the thirst of patients than that of the control group (30.7±3.2) (P<0.01); the 2-min static salivary flow rate of the treatment group and the control group was (0.52±0.22) mg / min and (0.39±0.19) mg / min, respectively, with statistically significant differences (P<0.05). Conclusion: The treatment group can effectively relieve the thirst symptoms of maintenance hemodialysis patients, increase the resting salivary flow rate of patients, reduce the fluid intake of patients, thereby reducing the cardiovascular burden, which has a positive significance for the health status and quality of life of dialysis patients.

[0073] Table 1 Comparison of dry mouth intensity scores (XQ) in 2 groups of patients before and after treatment ( point)

[0074]

[0075] Note: Comparison between before and after treatment ＊ P<0.01, comparison between treatment group and control group △ P<0.01

[0076] Table 2 Comparison of salivary flow rate (UWS) of 2 groups of patients before and after treatment ( mg / min)

[0077]

[0078] Note: Comparison between before and after treatment ＊ P<0.05, comparison between treatment group and control group △ P<0.05

[0079] Example 6

[0080] Typical cases:

[0081] Mr. Li, male, 56 years old, came to see a doctor for more than 8 years of maintenance hemodialysis and dry mouth and polydipsia for more than 3 years.

[0082] The patient has chronic nephritis for 26 years. Eight years ago, he went to the local hospital for treatment due to general edema, fatigue, poor appetite, nausea and vomiting. Urinalysis: protein 2+, occult blood 2+, renal function: urea nitrogen 21.7umol / l, blood creatinine 712.6mmol / L; blood potassium 5.8mmol / L, carbon dioxide binding capacity 17.5mmol / L; hemoglobin 101g / L, urinary system color Doppler ultrasound: bilateral renal cortical echo enhancement. Inpatient diagnosis: chronic kidney disease stage 5, chronic nephritis, renal anemia, metabolic acidosis. He was given regular hemodialysis three times a week to improve anemia, alkali supplementation and acid correction. The patient's edema subsided and the symptoms of nausea and vomiting disappeared. Three years ago, the patient gradually developed dry mouth and tongue, sticky mouth, frequent drinking, no urine, slightly dry stool, and normal blood sugar after multiple blood sugar checks. In the past six months, his thirst has become significantly worse, and he likes cold drinks. He has visited various people's hospitals for treatment many times. All of them considered thirst complications caused by uremia. There is no specific drug treatment. He was advised to take ice cubes, black plums or chew gum, but the effect was not good. I first saw the patient on May 12, 2022.

[0083] At the time of the examination, the patient was mentally fatigued, dry mouth and tongue, sticky and slightly bitter mouth, limb weakness, occasional itching of the skin, slightly dry stool, no urine, upset and insomnia. The tongue was red, the coating was thick and slightly yellow, and the pulse was stringy and slippery. Auxiliary examination: renal function: urea nitrogen 15.6umol / L, blood creatinine 618.2mmol / L; electrolytes: blood potassium 5.4mmol / L, blood calcium 2.3mmil / L, blood phosphorus 2.1mol / L carbon dioxide binding capacity 21.4mmol / L; hemoglobin 105g / L, blood sugar 5.9mmol / L, thyroid hormone 112pg / mL. No abnormalities were found in the five thyroid function tests.

[0084] The syndrome is characterized by stagnation of damp-heat, turbid toxins, stagnation of triple-burner qi, and deficiency of qi, yin and body fluids. The treatment is to clear away damp-heat, replenish qi and nourish yin, and promote the production of body fluids and relieve sore throat.

[0085] Prescription: American ginseng 12g, Northern Adenophora 12g, Scrophularia 12g, Black Plum 12g, Mulberry 12g, Angelica dahurica 9g, White Peony 9g, Mint 6g, Perilla 9g, Licorice 9g.

[0086] One dose per day x 14 doses

[0087] Follow-up: The patient's mental fatigue improved, dry mouth and tongue were significantly relieved, there was no bitter taste or sticky mouth, skin itching was relieved, stool was moist, no urine, mild irritability and insomnia. The tongue was slightly red with white greasy coating, and the pulse was stringy and slippery. Re-examination: Electrolytes: blood potassium 5.7mmol / L, blood calcium 2.2mmil / L, blood phosphorus 1.9mol / L; hemoglobin 109g / L.

[0088] Prescription: American ginseng 12g, Northern Adenophora 12g, Scrophularia 9g, Black Plum 9g, Mulberry 9g, Angelica dahurica 9g, White Peony 9g, Mint 6g, Perilla 6g, Licorice 6g.

[0089] One dose every two days x 14 doses

[0090] After 6 weeks, the patient was in good spirits, without polydipsia or sticky feeling in the mouth.

[0091] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. According to the content of this specification, many modifications and changes can be made. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A Chinese medicine composition for treating thirst during hemodialysis, characterized in that: The invention comprises the following raw materials in parts by weight: 10-20 parts of American ginseng, 10-20 parts of northern adenophora, 8-12 parts of Scrophularia, 8-12 parts of black plum, 8-12 parts of mulberry, 8-12 parts of angelica dahurica, 8-12 parts of white peony root, 4-6 parts of mint, 8-12 parts of perilla and 8-12 parts of liquorice.

2. The Chinese medicine composition for treating hemodialysis thirst syndrome according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 15 parts of American ginseng, 15 parts of northern adenophora, 10 parts of Scrophularia, 10 parts of black plum, 10 parts of mulberry, 10 parts of angelica dahurica, 10 parts of white peony root, 5 parts of mint, 10 parts of perilla, and 10 parts of liquorice.

3. A product for treating thirst during hemodialysis, characterized in that: The product comprises the above-mentioned Chinese medicine composition for treating thirst during hemodialysis and medically acceptable excipients; The products include but are not limited to lozenges and oral sprays.

4. A Chinese medicine lozenge for treating thirst during hemodialysis, characterized in that: The Chinese medicine lozenge for treating thirst during hemodialysis comprises the following raw materials in parts by weight: 5-30% of the Chinese medicine composition for treating thirst during hemodialysis according to claim 1, 5-15% of a binder, 1-5% of a lubricant, 1-5% of a flavoring agent, and the rest being a filler.

5. A Chinese medicine lozenge for treating thirst during hemodialysis according to claim 4, characterized in that: The Chinese medicine lozenge for treating thirst during hemodialysis comprises the following raw materials in parts by weight: 15% of the Chinese medicine composition for treating thirst during hemodialysis, 10% of a binder, 3% of a lubricant, 2% of a flavoring agent, and 70% of a filler.

6. A Chinese medicinal lozenge for treating thirst during hemodialysis according to claim 4 or 5, characterized in that: The filler is microcrystalline cellulose, lactose or mannitol, which increases the volume of the lozenge and makes it easier to shape; The binder is PVP, HPMC or gum arabic, which makes the raw materials and fillers bond together better; The lubricant is magnesium stearate or talc, which reduces the friction between the lozenge and the mold, making it easier to demold the lozenge; The flavoring agent is stevioside, citric acid or peppermint oil, which can mask the bitterness of the raw materials and enhance the taste. Different flavoring agents can be selected to adjust the taste.

7. A method for preparing a Chinese medicine lozenge for treating thirst during hemodialysis, characterized in that: The preparation method comprises: S1: Select American ginseng, Adenophora chinensis, Scrophularia ningpoensis, Prunus mume, mulberry, Angelica dahurica, Paeonia lactiflora, mint, Perilla frutescens, and Licorice according to the mass proportions of claim 1, grind them into fine powders, mix them, and pass through a 100-mesh sieve for later use; S2: Select auxiliary materials as needed, and mix the filler, adhesive, flavoring agent, and lubricant uniformly according to the proportions described in claim 6; S3: the Chinese medicine composition powder mixed in S1 and the auxiliary materials mixed in S2 are mixed and stirred evenly, and an appropriate amount of water or ethanol is added to form a soft material; S4: sieving the soft material prepared in S3 to make granules, and then drying; adding a lubricant after drying, mixing the granules evenly, and then tableting to prepare Chinese medicine lozenges for treating thirst during hemodialysis.

8. The method for preparing the Chinese medicine lozenge for treating hemodialysis thirst syndrome as claimed in claim 7, characterized in that: The powder of the Chinese medicine composition is mixed with the auxiliary materials to ensure that the components are evenly distributed; the granulation is carried out by wet granulation or dry granulation, the dried granules are sized, unqualified granules are removed, and a lubricant is added for mixing to ensure fluidity during tableting; At the same time, after granulation, the tablets are placed in a tablet press for tableting to obtain lozenges of desired shape and thickness; during tableting, attention should be paid to controlling parameters such as pressure, speed and temperature to ensure the quality and stability of the lozenges.

9. Use of the Chinese medicine composition for treating thirst during hemodialysis according to claim 1 in preparing a product for treating thirst during hemodialysis.

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