Pulsed electric field generation apparatus, apparatus and related methods

Abstract

The invention provides a pulsed electric field generation device, equipment and a related method, and relates to the technical field of medical instruments. The pulse electric field generating device comprises a first pulse generating circuit used for generating a first polarity pulse; the second pulse generation circuit is used for generating a second polarity pulse; the first pulse generating circuit and the second pulse generating circuit are both connected to the applying pieces, and in the working state, the first polarity pulse and the second polarity pulse are both applied to any applying piece in the at least one applying piece; the polarities of the first polarity pulse and the second polarity pulse are opposite, and the duration of the first polarity pulse and the duration of the second polarity pulse are partially overlapped. Therefore, the ablation effect of the pulse can be improved.

Description

Technical Field

[0001] The present disclosure relates to the field of medical device technology, and in particular to a pulse electric field generating device, equipment and related methods. Background Art

[0002] Irreversible electroporation (IRE) is a tumor ablation technique used to treat malignant tumors, and has a relatively clear therapeutic effect in the treatment of locally advanced pancreatic cancer. This technology uses high-voltage short-pulse direct current penetration technology to change the transmembrane potential to increase cell membrane permeability, resulting in the formation of nanoscale irreversible electroporation in the lipid bilayer structure of the cell membrane, which more accurately induces apoptosis of cells in the ablation area.

[0003] In the related art, electrode needles are usually used to alternately apply first polarity pulses and second polarity pulses, but the ablation force of this application method is relatively small. Summary of the invention

[0004] In view of this, the present disclosure provides a pulse electric field generating device, equipment and related methods to solve the problem of low ablation force in related technologies.

[0005] In a first aspect, a pulse electric field generating device is provided, comprising: a first pulse generating circuit for generating a first polarity pulse; a second pulse generating circuit for generating a second polarity pulse; and at least one application member, wherein the first pulse generating circuit and the second pulse generating circuit are both connected to the application member, and in a working state, the first polarity pulse and the second polarity pulse are both applied to any one of the at least one application member; the polarities of the first polarity pulse and the second polarity pulse are opposite, and the duration of the first polarity pulse partially overlaps with that of the second polarity pulse.

[0006] In a second aspect, a pulse electric field generating device is provided, comprising: a first pulse generating circuit for generating a first polarity pulse; a second pulse generating circuit for generating a second polarity pulse; at least two application members, the first pulse generating circuit and the second pulse generating circuit are respectively connected to at least one application member, for outputting a first polarity pulse and a second polarity pulse; wherein the polarities of the first polarity pulse and the second polarity pulse are opposite, and the duration of the first polarity pulse partially overlaps with that of the second polarity pulse.

[0007] In some embodiments, any two application members that respectively apply pulses of different polarities constitute an application member group, and at least two electric field action areas are formed within a preset range of the application member group.

[0008] In some embodiments, in the applicator group, at least one applicator has at least two pulse application zones.

[0009] In some embodiments, the applicator group includes a first applicator and a second applicator, the first applicator includes a first pulse application zone and a second pulse application zone, and the second applicator includes a third pulse application zone and a fourth pulse application zone.

[0010] In some embodiments, the first pulse application zone is connected to the first pulse generating circuit for outputting a first polarity pulse generated by the first pulse generating circuit, the third pulse application zone is connected to the second pulse generating circuit for outputting a second polarity pulse generated by the second pulse generating circuit, and the voltage of the second pulse application zone and the fourth pulse application zone is zero.

[0011] In some embodiments, the first pulse application zone and the third pulse application zone are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, and the second pulse application zone and the fourth pulse application zone are connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit.

[0012] In some embodiments, the first pulse application zone and the third pulse application zone are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, the second pulse application zone is connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit, and the voltage of the fourth pulse application zone is zero.

[0013] In some embodiments, the first pulse generating circuit includes: a first pulse generating module and a second pulse generating module, the first pulse generating module is used to generate a first electric pulse, the second pulse generating module is used to generate a second electric pulse, wherein the pulse parameters of the first electric pulse and the second electric pulse are different; the second pulse generating circuit includes: a third pulse generating module and a fourth pulse generating module, the third pulse generating module is used to generate a third electric pulse, the fourth pulse generating module is used to generate a fourth electric pulse, wherein the pulse parameters of the third electric pulse and the fourth electric pulse are different.

[0014] In some embodiments, the pulse parameters include at least one of pulse amplitude and pulse width.

[0015] In some embodiments, the first electric pulse and the third electric pulse have equal pulse amplitude and pulse width, opposite polarity, and partially overlap in duration; and the second electric pulse and the fourth electric pulse have equal pulse amplitude and pulse width, opposite polarity, and partially overlap in duration.

[0016] In some embodiments, the pulse amplitude of the first electric pulse is greater than the pulse amplitude of the second electric pulse, and the pulse width of the first electric pulse is less than the pulse width of the second electric pulse.

[0017] In some embodiments, the pulse width of the first electric pulse is in nanosecond order, and the pulse amplitude is 6000V-8000V; the pulse width of the second electric pulse is in microsecond order, and the pulse amplitude is 1000V-5000V.

[0018] In some embodiments, each application element is connected to at least one of the first pulse generating circuit and the second pulse generating circuit.

[0019] In a third aspect, a pulse electric field generating device is provided, comprising: the pulse electric field generating device provided in the first aspect or the second aspect; and a control module, respectively connected to the first pulse generating circuit and the second pulse generating circuit in the pulse electric field generating device, for generating a first pulse generating signal and a second pulse generating signal; wherein the first pulse generating signal is at least used to control the first pulse generating circuit to generate a first polarity pulse, and the second pulse generating signal is at least used to control the second pulse generating circuit to generate a second polarity pulse, the polarities of the first polarity pulse and the second polarity pulse are opposite, and the durations of the first polarity pulse and the second polarity pulse partially overlap, so that the first polarity pulse and the second polarity pulse are successively applied to the application member in the pulse electric field generating device.

[0020] In some embodiments, the pulse electric field generating device further comprises a switching module for switching the first polarity pulse and the second polarity pulse to be transmitted to different application members.

[0021] In a fourth aspect, a pulse cross control method is provided, which is applied to the pulse electric field generating device provided in the third aspect; the method includes: obtaining input information; generating a first pulse generating signal based on the input information; controlling the first pulse generating circuit of the pulse electric field generating device to generate a first polarity pulse based on the first pulse generating signal; generating a second pulse generating signal based on the input information within the duration of the first electric pulse; controlling the second pulse generating circuit of the pulse electric field generating device to generate a second polarity pulse based on the second pulse generating signal, wherein the polarities of the first polarity pulse and the second polarity pulse are opposite, and the durations of the first polarity pulse and the second polarity pulse partially overlap.

[0022] In a fifth aspect, a pulse electric field generating method is provided, which is applied to the pulse electric field generating device provided in the first aspect or the second aspect; the method comprises: acquiring a first pulse generating signal and a second pulse generating signal, the second pulse generating signal being generated within the duration of the first pulse generating signal; based on the first pulse generating signal and the second pulse generating signal, controlling the pulse electric field generating device to generate a plurality of combined pulses; wherein each combined pulse comprises a first polarity pulse and a second polarity pulse, the polarities of the first polarity pulse and the second polarity pulse are opposite, and the durations of the first polarity pulse and the second polarity pulse partially overlap.

[0023] In some embodiments, based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to generate multiple combination pulses, including: based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to generate multiple combination pulses, and there is an inter-pulse delay between two adjacent combination pulses.

[0024] In some embodiments, based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to generate multiple combined pulses, including: based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to alternately generate multiple first polarity pulses and second polarity pulses; wherein the pulse interval of the first polarity pulse is smaller than the pulse width of the second polarity pulse.

[0025] In some embodiments, the first pulse generating signal includes a first control signal and a second control signal, the second pulse generating signal includes a third control signal and a fourth control signal, and based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to generate multiple combination pulses, including: based on the first control signal and the third control signal, the pulse electric field generating device is controlled to generate multiple first combination pulses; based on the second control signal and the fourth control signal, the pulse electric field generating device is controlled to generate multiple second combination pulses; wherein the pulse parameters of the first combination pulse and the second combination pulse are different.

[0026] In some embodiments, the first pulse generating signal includes a first control signal and a second control signal, the second pulse generating signal includes a third control signal and a fourth control signal, and based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to generate multiple combination pulses, including: based on the first control signal and the third control signal, the pulse electric field generating device is controlled to generate a first combination pulse; based on the second control signal and the fourth control signal, the pulse electric field generating device is controlled to generate a second combination pulse; the above steps are repeated until the sum of the number of first combination pulses and second combination pulses reaches a preset value; wherein there is an inter-pulse delay between two adjacent combination pulses.

[0027] In some embodiments, the first pulse generating signal includes a first control signal and a second control signal, the second pulse generating signal includes a third control signal and a fourth control signal, and based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to generate multiple combination pulses, including: based on the first control signal and the third control signal, the pulse electric field generating device is controlled to generate a first combination pulse; based on the second control signal and the fourth control signal, the pulse electric field generating device is controlled to generate a second combination pulse; the above steps are repeated until the sum of the number of the first combination pulses and the second combination pulses reaches a preset value; wherein the durations of two adjacent combination pulses partially overlap.

[0028] In a sixth aspect, a pulse application method is provided, which is applied to the pulse electric field generating device provided in the second aspect; the method comprises: setting at least two application members in the pulse electric field generating device at a target position; selecting any two application members from the at least two application members; applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two application members in sequence; wherein the polarities of the first polarity pulse and the second polarity pulse are opposite, and the duration of the first polarity pulse partially overlaps with that of the second polarity pulse.

[0029] In some embodiments, any two applicators include a first applicator and a second applicator, the first applicator includes a first pulse application area and a second pulse application area, and the second applicator includes a third pulse application area and a fourth pulse application area; the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device are applied successively to any two applicators, including: applying the first polarity pulse to the first pulse application area; applying the second polarity pulse to the third pulse application area; wherein the voltage of the second pulse application area and the fourth pulse application area is zero.

[0030] In some embodiments, any two applicators include a first applicator and a second applicator, the first applicator includes a first pulse application area and a second pulse application area, and the second applicator includes a third pulse application area and a fourth pulse application area; the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device are applied successively to any two applicators, including: applying the first polarity pulse and the second polarity pulse to the first pulse application area and the second pulse application area respectively; applying the first polarity pulse or the second polarity pulse to the third pulse application area; wherein the voltage of the fourth pulse application area is zero.

[0031] In some embodiments, any two applicators include a first applicator and a second applicator, the first applicator includes a first pulse application area and a second pulse application area, and the second applicator includes a third pulse application area and a fourth pulse application area; the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device are applied successively to any two applicators, including: synchronously applying the first polarity pulse to the first pulse application area and the third pulse application area; synchronously applying the second polarity pulse to the second pulse application area and the fourth pulse application area.

[0032] The pulse electric field generating device provided by the present invention has a first polarity pulse and a second polarity pulse whose durations partially overlap and whose polarities are opposite, so as to enhance the ablation effect of the pulses; at the same time, the power supply voltage required by the device is reduced, and the requirements for the high voltage resistance and insulation of the components in the device are also reduced accordingly, thereby reducing the overall cost of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1aThe figure shows a time waveform diagram of a pulse voltage provided by the related art.

[0034] Figure 1b The figure shows another time waveform of a pulse voltage provided by the related art.

[0035] Figure 1c The figure shows a time waveform diagram of another pulse voltage provided by the related art.

[0036] Figure 1d Shown is a schematic structural diagram of a pulse electric field generating device provided by the related art.

[0037] Figure 2a Shown is a schematic structural diagram of a pulse electric field generating device provided in an embodiment of the present disclosure.

[0038] Figure 2b Shown is a schematic structural diagram of another pulse electric field generating device provided in an embodiment of the present disclosure.

[0039] Figure 2c Shown is a schematic structural diagram of an application member provided in an embodiment of the present disclosure.

[0040] Figure 3 Shown is a time waveform diagram of a pulse voltage provided by an embodiment of the present disclosure.

[0041] Figure 4 Shown is a schematic structural diagram of another application member provided in an embodiment of the present disclosure.

[0042] Figure 5a Shown is a schematic diagram of the electric field action area of ​​the first pulse low-voltage region provided by an embodiment of the present disclosure.

[0043] Figure 5b Shown is a schematic diagram of the electric field action area of ​​a pulse high voltage area provided in an embodiment of the present disclosure.

[0044] Figure 5c Shown is a schematic diagram of the electric field action area of ​​the second pulse low-voltage region provided by an embodiment of the present disclosure.

[0045] Figure 6 Shown is a schematic diagram of the electric field action area of ​​another pulse high voltage area provided in an embodiment of the present disclosure.

[0046] Figure 7 Shown is a schematic diagram of the electric field action area of ​​another pulse high voltage area provided in an embodiment of the present disclosure.

[0047] Figure 8 Shown is a schematic structural diagram of another pulse electric field generating device provided in an embodiment of the present disclosure.

[0048] Fig. 9 Shown is a schematic structural diagram of a pulse electric field generating device provided in an embodiment of the present disclosure.

[0049] Fig.10 The figure is a flow chart of a pulse cross control method provided in an embodiment of the present disclosure.

[0050] Fig.11 Shown is a flow chart of a pulse electric field generating method provided in an embodiment of the present disclosure.

[0051] Fig.12 Shown is a time waveform diagram of another pulse voltage provided in an embodiment of the present disclosure.

[0052] Fig.13 Shown is a time waveform diagram of another pulse voltage provided in an embodiment of the present disclosure.

[0053] Fig.14 Shown is a time waveform diagram of another pulse voltage provided in an embodiment of the present disclosure.

[0054] Fig.15 Shown is a time waveform diagram of another pulse voltage provided in an embodiment of the present disclosure.

[0055] Fig.16 Shown is a time waveform diagram of another pulse voltage provided in an embodiment of the present disclosure.

[0056] Fig.17 Shown is a flow chart of a pulse application method provided in an embodiment of the present disclosure. DETAILED DESCRIPTION

[0057] The following will be combined with the drawings in the embodiments of the present disclosure to clearly and completely describe the technical solutions in the embodiments of the present disclosure. Obviously, the described embodiments are only part of the embodiments of the present disclosure, not all of the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present disclosure.

[0058] As mentioned above, there are usually three ways to generate pulse electric fields in the related art. Figure 1a As shown, method 1 is: first output a first polarity pulse, and after a certain pulse delay, output a second polarity pulse, thereby outputting bipolar pulses alternately. Figure 1b As shown in FIG. 2 , method 2 is: outputting multiple unipolar pulses at a certain pulse interval delay. Figure 1c As shown, method 3 is: after outputting multiple pulses according to the above method 1, reducing the pulse amplitude and increasing the pulse width, and continuing to output multiple pulses according to the above method 1.

[0059] The above three methods all have relatively high requirements for the voltage peak of the device, and thus put forward higher requirements for the high voltage resistance, insulation and power supply voltage of the components of the entire device, and the overall cost of the device is high. In addition, the ablation intensity of the pulse is relatively small.

[0060] In view of this, the present disclosure provides a pulse electric field generating device, comprising: a first pulse generating circuit for generating a first polarity pulse; a second pulse generating circuit for generating a second polarity pulse; at least one application member, the first pulse generating circuit and the second pulse generating circuit are both connected to the application member, and in a working state, the first polarity pulse and the second polarity pulse are both applied to any one of the at least one application member; the polarities of the first polarity pulse and the second polarity pulse are opposite, and the duration of the first polarity pulse and the second polarity pulse partially overlap. In this way, the ablation effect of the pulse can be improved.

[0061] The pulse electric field generating device provided by the present disclosure will be described in detail below with reference to the accompanying drawings and embodiments.

[0062] Figure 2a FIG. 1 is a schematic diagram of the structure of a pulse electric field generating device provided by an embodiment of the present disclosure. Figure 2a As shown, the pulse electric field generating device includes: a first pulse generating circuit 210, a second pulse generating circuit 220 and at least one applying member 230. The applying member 230 is connected to the first pulse generating circuit 210 and the second pulse generating circuit 220 respectively.

[0063] The first pulse generating circuit 210 is used to generate a first polarity pulse, and the second pulse generating circuit 220 is used to generate a second polarity pulse. At least two pulse application areas are provided on the application member 230, at least one of the at least two pulse application areas applies a first polarity pulse, and at least one of the other pulse application areas applies a second polarity pulse. If there is a pulse application area that does not apply a first polarity pulse or a second polarity pulse, it can be grounded. Each pulse application area is insulated to avoid short circuit.

[0064] Continue to refer Figure 2a The applying member 230 includes a first pulse applying area 2311 and a second pulse applying area 2312, wherein the first pulse applying area 2311 applies a first polarity pulse, and the second pulse applying area 2312 applies a second polarity pulse. When applying the pulse, the first polarity pulse is first applied to the first pulse applying area 2311,

[0065] The voltage of the second pulse application area 2312 is 0V. At this time, there is a potential difference between the first pulse application area 2311 and the second pulse application area 2312, so an electric field action area can be generated. Then, during the duration of the first polarity pulse, the second polarity pulse is simultaneously applied to the second pulse application area 2312. At this time, the range of the above-mentioned electric field action area remains unchanged, but the electric field strength increases. Then, after the first polarity pulse stops being applied, the second polarity pulse can still continue for a period of time. At this time, the range of the above-mentioned electric field action area remains unchanged, but the electric field strength weakens. When the first polarity pulse and the second polarity pulse are simultaneously applied to the application member 230, the electric field strength of the electric field action area is equal to the sum of the pulse amplitudes of the first polarity pulse and the second polarity pulse. In order to generate the same electric field strength as the device in the related art, the embodiment of the present disclosure only requires half of the power supply voltage in the related art; the requirements for the high voltage resistance and insulation of the components in the device can also be reduced by half, reducing the overall cost of the device.

[0066] Based on the above method, the time waveform of the pulse voltage generated by the pulse electric field generating device is as follows: Figure 3 As shown. The duration of a first polarity pulse and a second polarity pulse partially overlap, and the overlap time is less than the non-overlapping duration of the first polarity pulse and the second polarity pulse respectively. A first polarity pulse and a second polarity pulse whose duration partially overlap are referred to as a combined pulse below. The pulse amplitude, pulse width, overlap time and inter-pulse delay of the first polarity pulse and the second polarity pulse can be set according to actual conditions. Exemplarily, the pulse amplitude of the first polarity pulse and the second polarity pulse can be 1000V to 20000V, the pulse width can be nanosecond level or 100 nanosecond level, and the inter-pulse delay is 100 nanoseconds to 1 millisecond.

[0067] The overlapped part of the first polarity pulse and the second polarity pulse forms a pulse high voltage area, and the non-overlapped part of the first polarity pulse and the second polarity pulse forms a pulse low voltage area, that is, in one combined pulse, two pulse low voltage areas and a pulse high voltage area between the two can be formed.

[0068] The pulse high-pressure area is a narrow pulse width high-pressure pulse, which has a higher ablation rate, but a smaller ablation area; the pulse low-pressure area is a wide pulse width low-pressure pulse, which has a larger ablation area, but a lower ablation rate. Therefore, the combined use of the two can significantly improve the ablation effect of the device.

[0069] Specifically, during the ablation process, the pulse low-voltage area first reduces the damage threshold of the target cells, and then the pulse high-voltage area forms more micropores on the cell membrane, and then the pulse low-voltage area further expands the cell micropores to an irreversible state. In a combined pulse, there is no time delay between the pulse high-voltage area and the pulse low-voltage area. For cells, the force exerted on the ions is in a sudden form, which has a greater impact on the cell membrane. In addition, the pulse width of the pulse high-voltage area is narrower than the original pulse width, and the ablation effect it can provide is better. The subsequent pulse low-voltage area can compensate and increase its ablation area, thereby obtaining a better pulse ablation effect.

[0070] The following is an introduction to a pulse electric field generating device in the related art. Figure 1d As shown, the device includes a pulse generating circuit 110 for providing positive and negative polarity pulses, and two electrode needles 120. Each electrode needle is provided with a pulse applying region 121, the pulse applying region of one electrode needle is used to apply a positive polarity pulse, and the pulse applying region of the other electrode needle is used to apply a negative polarity pulse. Figure 1d Although the device shown can also implement the above-mentioned pulse application method, compared with the device in the present disclosure, the embodiment of the present disclosure can achieve the effect using only one application member, which improves the usability of the device of the embodiment of the present disclosure and reduces its difficulty of use.

[0071] Continue to refer to Figure 2a , the specific structures of the first pulse generating circuit 210 and the second pulse generating circuit 220 are introduced in detail.

[0072] Specifically, the first pulse generating circuit 210 includes: a first power supply 211, and a first pulse generating module 212 connected to the first power supply 211. The first pulse generating module 212 further includes a plurality of first pulse generating units 2121 connected in parallel. The first power supply 211 provides electric energy to the first pulse generating module 212, and the first pulse generating module 212 stores the electric energy in the plurality of first pulse generating units 2121. In response to the first control signal, the first pulse generating units 2121 release energy in sequence to form a first polarity pulse.

[0073] Specifically, the second pulse generating circuit 220 includes: a third power supply 221, and a third pulse generating module 222 connected to the third power supply 221. The third pulse generating module 222 further includes a plurality of third pulse generating units 2221 connected in parallel. The third power supply 221 provides electric energy to the third pulse generating module 222, and the third pulse generating module 222 stores the electric energy in the plurality of third pulse generating units 2221. In response to the second control signal, the third pulse generating units 2221 release energy in sequence to form a second polarity pulse.

[0074] The second control signal is generated within the duration of the first polarity pulse, so that the second polarity pulse generated in response to the second control signal partially overlaps with the duration of the first polarity pulse. Exemplarily, the first control signal and the second control signal can be generated by a control module in the pulse electric field generating device, or by an external control system, and the present disclosure does not make specific restrictions on this.

[0075] Next, another pulse electric field generating device provided by an embodiment of the present disclosure is introduced. The device of this embodiment generates at least two electric field action areas through the interaction of two application members, further expanding the ablation force and ablation range.

[0076] like Figure 2b As shown, the pulse electric field generating device includes: a first pulse generating circuit 210 , a second pulse generating circuit 220 and at least two applying members 230 .

[0077] The first pulse generating circuit 210 is used to generate a first polarity pulse, and the second pulse generating circuit 220 is used to generate a second polarity pulse. The first pulse generating circuit 210 and the second pulse generating circuit 220 are respectively connected to at least one application member 230 so that the application member 230 outputs a first polarity pulse and a second polarity pulse. Among the at least two application members 230, any two application members 230 that respectively apply pulses of different polarities constitute an application member group, and the two application members in an application member group are punctured together near the target load (such as biological tissue, tumor, etc.) to conduct the pulse generated by the pulse electric field generating device to the target cells. It can be understood that Figure 2b The number of application members and the connection method shown are schematic. The structure and Figure 2b The structures shown are similar, and the multiple groups of application members are all connected to the first pulse generating circuit 210 and / or the second pulse generating circuit 220, and the repeated parts are not repeated.

[0078] For example, if the first pulse generating circuit 210 is connected to n application elements in total, and the second pulse generating circuit 220 is connected to m application elements in total, then the m+n application elements can form n×m application element groups, and each application element group can independently apply a first polarity pulse and a second polarity pulse, where m and n are positive integers.

[0079] The first polarity pulse generated by the first pulse generating circuit 210 is opposite to the polarity of the second polarity pulse generated by the second pulse generating circuit 220. Exemplarily, the first polarity pulse may be a positive polarity pulse, and correspondingly, the second polarity pulse may be a negative polarity pulse; or, the first polarity pulse may be a negative polarity pulse,

[0080] Correspondingly, the second polarity pulse may be a positive polarity pulse, and the present disclosure does not impose any specific limitation on this.

[0081] When a first polarity pulse and a second polarity pulse are applied successively to a group of applicators with partially overlapping durations, the pulse application areas of the two applicators can be set separately so that at least two electric field action areas can be simultaneously formed within a preset range of the applicator group to expand the ablation intensity and ablation range.

[0082] A method for setting the pulse application area in the application component group is introduced below.

[0083] In some embodiments, in the application member group, at least one application member has at least two pulse application zones. Figure 2c As shown, one application member group includes a first application member 231 and a second application member 232; the first application member 231 includes a first pulse application area 2311 and a second pulse application area 2312, and the two pulse application areas are insulated from each other; the second application member 232 includes a third pulse application area 2321. In this embodiment, when the first polarity pulse or the second polarity pulse is applied to the application member group in sequence, at least two electric field action areas can be generated between the three pulse application areas.

[0084] As a possible implementation, a first polarity pulse is first applied to the first pulse application area 2311 and the second pulse application area 2312, and the voltage of the third pulse application area 2321 is 0V. At this time, there is a potential difference between the first pulse application area 2311 and the third pulse application area 2321, and between the second pulse application area 2312 and the third pulse application area 2321, so two electric field action areas can be generated. Then, during the duration of the first polarity pulse, a second polarity pulse is simultaneously applied to the third pulse application area 2321. At this time, the range of the above two electric field action areas remains unchanged, but the electric field strength increases. Then, after the first polarity pulse stops being applied, the second polarity pulse can continue for a period of time. At this time, the range of the above two electric field action areas remains unchanged, but the electric field strength decreases.

[0085] As another possible implementation, the second pulse application area 2312 may be grounded. In this case, the voltage of the second pulse application area 2312 is constantly 0 V, and the first polarity pulse and the second polarity pulse are applied by the first pulse application area 2311 and the third pulse application area 2321 respectively.

[0086] Through the above arrangement, the pulse electric field generating device provided in the embodiment of the present disclosure can form multiple electric field action areas, further expanding the ablation intensity and ablation range.

[0087] The above describes a situation in which two application members in a group of application members output a first polarity pulse and a second polarity pulse respectively. Of course, each application member can also output a first polarity pulse and a second polarity pulse at the same time. Specifically, each application member can be connected to at least one of the first pulse generating circuit and the second pulse generating circuit, so that each application member can apply a first polarity pulse and / or a second polarity pulse. Based on this flexible connection method, the following introduces several other ways to set the pulse application area in the application member group.

[0088] Figure 4 FIG. 2 is a schematic diagram of the structure of another application member provided in an embodiment of the present disclosure. Figure 4 As shown, a group of application members includes a first application member 231 and a second application member 232. The first application member 231 includes a first pulse application area 2311 and a second pulse application area 2312, and the second application member 232 includes a third pulse application area 2321 and a fourth pulse application area 2322.

[0089] Among them, the materials of the first pulse application area 2311, the second pulse application area 2312, the third pulse application area 2321 and the fourth pulse application area 2322 are conductive materials; the materials of the remaining surfaces of the first application member 231 and the second application member 232 except the pulse application area are insulating materials to ensure user safety.

[0090] The following describes a specific method for setting pulses applied to multiple application areas in a set of application members.

[0091] In some embodiments, the first application member 231 is connected to the first pulse generating circuit 210, and the second application member 232 is connected to the second pulse generating circuit 220. The first pulse application area 2311 of the first application member 231 outputs the first polarity pulse generated by the first pulse generating circuit 210; the third pulse application area 2321 of the second application member 232 outputs the second polarity pulse generated by the second pulse generating circuit 220; the second pulse application area 2312 and the fourth pulse application area 2322 do not apply pulses, and the voltages of the two application areas are both zero. The voltage of the pulse application area being zero can be achieved by grounding the pulse application area.

[0092] When the application member provided in the above embodiment applies a combined pulse, in the first pulse low voltage area, the first pulse application area 2311 outputs a first polarity pulse, and the second pulse application area 2312, the third pulse application area 2321 and the fourth pulse application area 2322 do not apply pulses, so as to generate three electric field action areas (such as Figure 5aIn the pulse high voltage area, the first pulse application area 2311 outputs a first polarity pulse, the third pulse application area 2321 outputs a second polarity pulse, and the second pulse application area 2312 and the fourth pulse application area 2322 do not apply pulses, so as to generate five electric field action areas (such as Figure 5b In the second pulse low voltage area, the third pulse application area 2321 outputs a second polarity pulse, and the first pulse application area 2311, the second pulse application area 2312 and the fourth pulse application area 2322 do not apply pulses to generate three electric field action areas (as shown in FIG. Figure 5c As shown). In the above figure, the first polarity pulse is represented by a +1500V electric pulse, and the second polarity pulse is represented by a -1500V electric pulse. It can be understood that this representation method is only schematic, intended to more clearly distinguish different pulses, and should not be understood as a limitation to the present disclosure.

[0093] Specifically, Figure 5b For example, an electric field action zone is generated between the first pulse application zone 2311 and the third pulse application zone 2321, and the electric field strength of the electric field action zone is the largest, which is -1500V, +1500V (the electric field action zone with the largest electric field strength is represented in gray in the figure); an electric field action zone is formed between the first pulse application zone 2311 and the second pulse application zone 2312, between the first pulse application zone 2311 and the fourth pulse application zone 2322, between the third pulse application zone 2321 and the second pulse application zone 2312, and between the third pulse application zone 2321 and the fourth pulse application zone 2322, respectively, and the electric field strength of these four electric field action zones is smaller than the electric field strength between the first pulse application zone 2311 and the third pulse application zone 2321.

[0094] The pulse electric field generating device provided in the embodiment of the present disclosure is capable of generating multiple electric field action zones, and its ablation intensity and ablation range are significantly improved.

[0095] Two other implementations are described below. Although the connection methods between the circuit and the application member and the pulses applied in the pulse application area are different in various implementations, multiple electric field action areas with different electric field strengths can be formed.

[0096] In some embodiments, the first application member 231 and the second application member 232 are both connected to the first pulse generating circuit 210, and the second application member 232 is also connected to the second pulse generating circuit 220. The first pulse applying area 2311 and the third pulse applying area 2321 output the first polarity pulse generated by the first pulse generating circuit 210; the second pulse applying area 2312 outputs the second polarity pulse generated by the second pulse generating circuit 220; the fourth pulse applying area 2322 does not apply a pulse, and its voltage is zero.

[0097] When the application member provided in the above embodiment applies a combined pulse, in the first pulse low-voltage zone, the first pulse application zone 2311 and the third pulse application zone 2321 output a first polarity pulse, and the second pulse application zone 2312 and the fourth pulse application zone 2322 do not apply a pulse, so as to generate four electric field action zones. In the pulse high-voltage zone, the first pulse application zone 2311 and the third pulse application zone 2321 output a first polarity pulse, the second pulse application zone 2312 outputs a second polarity pulse, and the fourth pulse application zone 2322 does not apply a pulse, so as to generate five electric field action zones (such as Figure 6 In the second pulse low voltage region, the second pulse applying region 2312 outputs a second polarity pulse, and the first pulse applying region 2311, the third pulse applying region 2321 and the fourth pulse applying region 2322 do not apply pulses to generate three electric field action regions.

[0098] Specifically, Figure 6 For example, an electric field action zone is formed between the first pulse application zone 2311 and the second pulse application zone 2312, and between the second pulse application zone 2312 and the third pulse application zone 2321, and the electric field intensities of these two electric field action zones are the largest; an electric field action zone is formed between the first pulse application zone 2311 and the fourth pulse application zone 2322, between the second pulse application zone 2312 and the fourth pulse application zone 2322, and between the third pulse application zone 2321 and the fourth pulse application zone 2322.

[0099] Therefore, the pulse electric field generating device provided in the embodiment of the present disclosure can generate multiple electric field action areas, and has two electric field action areas with the largest electric field strength, and its ablation intensity and ablation range are significantly improved.

[0100] In some embodiments, the first application member 231 and the second application member 232 are both connected to the first pulse generating circuit 210, and at the same time, the first application member 231 and the second application member 232 are also connected to the second pulse generating circuit 220. The first pulse applying area 2311 and the third pulse applying area 2321 output the first polarity pulse generated by the first pulse generating circuit 210; the second pulse applying area 2312 and the fourth pulse applying area 2322 output the second polarity pulse generated by the second pulse generating circuit 220.

[0101] When the application member provided in the above embodiment applies a combined pulse, in the first pulse low-voltage area, the first pulse application area 2311 and the third pulse application area 2321 output a first polarity pulse, and the second pulse application area 2312 and the fourth pulse application area 2322 do not apply a pulse, so as to generate four electric field action areas. In the pulse high-voltage area, the first pulse application area 2311 and the third pulse application area 2321 output a first polarity pulse, and the second pulse application area 2312 and the fourth pulse application area 2322 output a second polarity pulse, so as to generate four electric field action areas (such as Figure 7 In the second pulse low voltage region, the second pulse applying region 2312 and the fourth pulse applying region 2322 output second polarity pulses, and the first pulse applying region 2311 and the third pulse applying region 2321 do not apply pulses, so as to generate four electric field action regions.

[0102] Specifically, Figure 7 For example, an electric field action zone is formed between the first pulse application zone 2311 and the second pulse application zone 2312, between the first pulse application zone 2311 and the fourth pulse application zone 2322, between the second pulse application zone 2312 and the third pulse application zone 2321, and between the third pulse application zone 2321 and the fourth pulse application zone 2322, and the electric field strengths of these four electric field action zones are the same.

[0103] The pulse electric field generating device provided in the embodiment of the present disclosure can generate multiple electric field action zones, and the electric field strength of these four electric field action zones is equivalent to the maximum electric field strength in other implementation methods, and the ablation intensity and ablation range are significantly improved.

[0104] It is understandable that the above embodiments only introduce the case where one or two pulse application areas are set on the application member. Based on the same inventive concept, multiple pulse application areas can also be set on the same application member, and the number of electric field action areas generated will also increase accordingly. At the same time, the pulses applied to each pulse application area can also be flexibly set, and the present disclosure does not impose specific restrictions on this.

[0105] Similarly, the above embodiment also only introduces a specific implementation method of applying the first polarity pulse and the second polarity pulse to a group of application members. Based on the same inventive concept, each application member of the device can be connected to at least one of the first pulse generating circuit and the second pulse generating circuit. In this case, each application member of the device can apply the first polarity pulse and / or the second polarity pulse.

[0106] When the first polarity pulse and the second polarity pulse are generated and transmitted to the application member in sequence, any two application members to which pulses of different polarities are applied can constitute an application member group, and at least two electric field action areas can be formed within a preset range of the application member group. Therefore, multiple electric field action areas of different ranges can be obtained by switching the first polarity pulse and the second polarity pulse generated by the first pulse generating circuit and the second pulse generating circuit and transmitting them to different application members.

[0107] Figure 8 FIG. 2 is a schematic diagram of the structure of another pulse electric field generating device provided by an embodiment of the present disclosure. Figure 8 As shown, the pulse electric field generating device of this embodiment is Figure 2b The pulse electric field generating device shown is partially the same, and the differences are as follows. In addition to the first power supply 211 and the first pulse generating module 212, the first pulse generating circuit 210 also includes: a second power supply 213, and a second pulse generating module 214 connected to the second power supply 213. Among them, the second pulse generating module 214 includes a plurality of second pulse generating units 2141 connected in parallel. The second power supply 213 provides electrical energy to the second pulse generating module 214, and the second pulse generating module 214 stores the electrical energy in the plurality of second pulse generating units 2141 respectively. The second pulse generating units 2141 release energy in sequence according to the control signal to form a first polarity pulse.

[0108] The first polarity pulse generated by the second pulse generation module 214 has different pulse parameters from the first polarity pulse generated by the first pulse generation module 212. Therefore, the first polarity pulse generated by the first pulse generation module 212 is referred to as the first electrical pulse, and the first polarity pulse generated by the second pulse generation module 214 is referred to as the second electrical pulse.

[0109] In addition to the third power supply 221 and the third pulse generating module 222, the second pulse generating circuit 220 further includes: a fourth power supply 223, and a fourth pulse generating module 224 connected to the fourth power supply 223. The fourth pulse generating module 224 further includes a plurality of fourth pulse generating units 2241 connected in parallel. The fourth power supply 223 provides electric energy to the fourth pulse generating module 224, and the fourth pulse generating module 224 stores the electric energy in the plurality of fourth pulse generating units 2241 respectively. The fourth pulse generating units 2241 release energy in sequence according to the control signal to form a first polarity pulse.

[0110] The first polarity pulse generated by the fourth pulse generating module 224 has different pulse parameters from the first polarity pulse generated by the third pulse generating module 222. Therefore, the first polarity pulse generated by the third pulse generating module 222 is referred to as the third electrical pulse, and the first polarity pulse generated by the fourth pulse generating module 224 is referred to as the fourth electrical pulse.

[0111] In some embodiments, the first power source 211 and the second power source 213 can be configured as one power source, and the third power source 221 and the fourth power source 223 can be configured as one power source to reduce the complexity of the device structure and the power supply circuit.

[0112] The pulse electric field generating device provided in the embodiment of the present disclosure can respectively generate a first electric pulse, a second electric pulse, a third electric pulse and a fourth electric pulse with different pulse parameters. By changing their pulse parameters, the pulse electric field generating device can flexibly adapt to various usage scenarios.

[0113] In some embodiments, the pulse parameters include at least one of pulse amplitude and pulse width. By adjusting the pulse amplitude and / or pulse width of the pulse, the pulse characteristics can be changed. Exemplarily, an electrical pulse with a high pulse amplitude and a narrow pulse width has a higher ablation intensity and a smaller ablation area than an electrical pulse with a low pulse amplitude and a wide pulse width.

[0114] The pulse electric field generating device provided in the embodiment of the present disclosure is capable of generating two groups of combined pulses with different pulse amplitudes and / or pulse widths, which cooperate with each other to obtain a better ablation effect.

[0115] In some embodiments, the pulse amplitude and pulse width of the first electric pulse and the third electric pulse are equal, and their durations partially overlap; and the pulse amplitude and pulse width of the second electric pulse and the fourth electric pulse are equal, and their durations partially overlap.

[0116] Exemplarily, the second electric pulse is a positive polarity pulse, and the fourth electric pulse is a negative polarity pulse. Moreover, the pulse amplitudes of the two can be 1000V to 5000V, the pulse width can be microseconds or 100 microseconds, and the delay between pulses can be 1 microsecond to 1 millisecond.

[0117] The disclosed embodiment can generate two groups of combined pulses with different pulse amplitudes and pulse widths. The first electric pulse and the third electric pulse are referred to as first combined pulses, and the second electric pulse and the fourth electric pulse are referred to as second combined pulses.

[0118] In some embodiments, the pulse amplitude of the first electric pulse is greater than the pulse amplitude of the second electric pulse, and the pulse width of the first electric pulse is less than the pulse width of the second electric pulse. Correspondingly, the pulse amplitude of the third electric pulse is greater than the pulse amplitude of the fourth electric pulse, and the pulse width of the third electric pulse is less than the pulse width of the fourth electric pulse.

[0119] As a preferred embodiment, the pulse width of the first electric pulse and the third electric pulse is in nanosecond order, and the pulse amplitude is 6000V-8000V, and the pulse width of the second electric pulse and the fourth electric pulse is in microsecond order, and the pulse amplitude is 1000V-5000V.

[0120] In some embodiments, microsecond pulses can be replaced by millisecond pulses, which also have the characteristics of large ablation area and low ablation rate.

[0121] Based on the same inventive concept, a pulse electric field generating device is also provided in an embodiment of the present disclosure. The device includes a pulse electric field generating device and a control module.

[0122] Specifically, the pulse electric field generating device comprises a first pulse generating circuit, a second pulse generating circuit and at least two applying members. The control module is connected to the first pulse generating circuit and the second pulse generating circuit respectively.

[0123] The control module can generate a first pulse generating signal and a second pulse generating signal. The first pulse generating signal can control the first pulse generating circuit to generate a first polarity pulse, and the second pulse generating signal can control the second pulse generating circuit to generate a second polarity pulse, and the duration of the first polarity pulse and the second polarity pulse partially overlap. The first polarity pulse and the second polarity pulse are applied to the application member in the pulse electric field generating device in sequence.

[0124] In some other embodiments, the first pulse generating circuit includes a first pulse generating module and a second pulse generating module; the second pulse generating circuit includes a third pulse generating module and a fourth pulse generating module. Accordingly, the first pulse generating signal includes a first control signal and a second control signal; the second pulse generating signal includes a third control signal and a fourth control signal.

[0125] The first control signal is used to control the first pulse generating module to generate a first electrical pulse, and the third control signal is used to control the third pulse generating module to generate a third electrical pulse. The durations of the first electrical pulse and the third electrical pulse partially overlap.

[0126] The second control signal is used to control the second pulse generating module to generate a second electrical pulse, and the fourth control signal is used to control the fourth pulse generating module to generate a fourth electrical pulse, and the duration of the second electrical pulse and the fourth electrical pulse partially overlap. The pulse parameters of the above two combined pulses are different.

[0127] The pulse electric field generating device provided in the embodiment of the present disclosure can control the pulse electric field generating device to generate the first combined pulse and / or the second combined pulse through the control module. It can be understood that since the principle of solving the problem in the embodiment of the device is similar to that in the above-mentioned device embodiment, the implementation of the embodiment of the device can refer to the implementation of the above-mentioned device embodiment, and the repeated parts will not be repeated.

[0128] Exemplarily, the control module includes a host computer (host + display), a program control module, etc. The control signal can be automatically generated based on a preset setting, or can be generated according to information input by a user, wherein the input information may include pulse amplitude, pulse width, delay between pulses, and the order of applying two combined pulses, etc.

[0129] When applying pulses using the device of the embodiment of the present disclosure, it is best to have only one application component group in the state of applying pulses at the same time, otherwise the problem of electric field disorder is likely to occur. Therefore, in a preferred embodiment, pulses are applied to one application component group first, and then pulses are applied to the other application component group.

[0130] To implement the above solution, the pulse electric field generating device may further include a switching module. As described above, of the at least two application members, two application members form a group. The switching module is capable of switching the first polarity pulse and the second polarity pulse to different application members. Through the switching module, the device provided by the embodiment of the present disclosure can act on multiple targets at the same time to improve its treatment efficiency and reduce treatment costs.

[0131] In some embodiments, the pulse electric field generating device also includes a power supply module and a human-computer interaction module. The power supply module is used to supply power to the first power supply, the second power supply, the third power supply and the fourth power supply, as well as other modules of the device. Exemplarily, the power supply module includes a high-voltage power supply, a power filter, an isolation transformer, an auxiliary power supply module, an energy storage module, etc. The human-computer interaction module includes a display, a foot switch, an emergency stop switch and various interfaces. The display is used to display the operating status of the device to improve the user experience; the foot switch and the emergency stop switch are used to control the start and stop of the device to further ensure the personal safety of the user.

[0132] Fig. 9 FIG. 1 is a schematic diagram of the structure of a pulse electric field generating device provided by an embodiment of the present disclosure. Fig. 9 As shown, the pulse electric field generating device includes the above-mentioned host computer 910, program control module 920, pulse generating circuit 930, switching module 940 and power supply and energy storage module 950. The host computer 910 and the program control module 920 are connected by optical fiber communication, and together constitute a control module; the program control module 920 is connected to the emergency stop switch 960, the foot switch 970 and the signal line interface 980; the pulse generating circuit 930 includes a first pulse generating circuit and a second pulse generating circuit; the switching module 940 is connected to the treatment output interface 990, and the treatment output interface 990 is further connected to at least two application members; the power supply and energy storage module 950 provides energy for the program control module 920, the switching module 940 and the pulse generating circuit 930. The electric energy of the power supply and energy storage module 950 comes from the power supply system, which includes the national power grid or a private power supply network, or a battery, etc. As Fig. 9As shown, the power supply system not only supplies power to the power supply and energy storage module 950 , but also supplies power to the host computer 910 .

[0133] Based on the same inventive concept, a pulse cross control method is also provided in the embodiment of the present disclosure, which is applied to the pulse electric field generating device provided in the embodiment of the present disclosure, and more specifically, can be applied to the control module in the pulse electric field generating device. Since the principle of solving the problem in the embodiment of the method is similar to that in the above-mentioned device embodiment and equipment embodiment, the implementation of the embodiment of the method can refer to the implementation of the above-mentioned device embodiment and equipment embodiment, and the repeated parts will not be repeated.

[0134] Fig.10 FIG. 1 is a flow chart of a pulse crossover control method provided by an embodiment of the present disclosure, such as Fig.10 As shown, the pulse cross control method provided by the embodiment of the present disclosure includes the following steps.

[0135] S1010, obtaining input information.

[0136] The input information may be information such as pulse parameters input by the user in the host computer, specific pulse application methods, etc. For example, the input information indicates that the user wants the device to generate a combined pulse with a pulse amplitude of 10000V and a pulse width of nanoseconds; or the input information indicates that the user wants the device to generate a combined pulse with a pulse amplitude of 3000V and a pulse width of microseconds.

[0137] S1020, generating a first pulse generation signal based on the input information.

[0138] S1030, based on the first pulse generating signal, controlling the first pulse generating circuit of the pulse electric field generating device to generate a first polarity pulse.

[0139] S1040, generating a second pulse generation signal based on input information within the duration of the first electrical pulse.

[0140] S1050, based on the second pulse generating signal, controlling the second pulse generating circuit of the pulse electric field generating device to generate a second polarity pulse.

[0141] Based on the above steps, the pulse electric field generating device can generate a first polarity pulse and a second polarity pulse in an alternating manner to obtain a combined pulse. The first polarity pulse and the second polarity pulse are applied to at least two application members in succession to form at least two electric field action areas within a preset range of any two application members to which different polarity pulses are applied respectively.

[0142] According to the method in the above embodiment, by changing the input information, the device can generate the first combination pulse and / or the second combination pulse with different pulse parameters. It can be understood that during the use of the device, the first combination pulse or the second combination pulse can be generated separately, or the first combination pulse and the second combination pulse can be generated, which is specifically determined by the content of the input information or the setting of the device.

[0143] Based on the same inventive concept, a pulse electric field generating method is also provided in the embodiment of the present disclosure, which is applied to the pulse electric field generating device or pulse electric field generating equipment provided in the embodiment of the present disclosure. Since the principle of solving the problem in the embodiment of the method is similar to that in the above-mentioned device embodiment and equipment embodiment, the implementation of the embodiment of the method can refer to the implementation of the above-mentioned device embodiment and equipment embodiment, and the repeated parts will not be repeated.

[0144] Fig.11 FIG. 1 is a flow chart of a pulse electric field generating method provided by an embodiment of the present disclosure, such as Fig.11 As shown, the pulse electric field generating method provided by the embodiment of the present disclosure includes the following steps.

[0145] S1110: Acquire a first pulse generation signal and a second pulse generation signal.

[0146] The first pulse generating signal and the second pulse generating signal can be automatically generated based on a preset setting, or can be generated according to information input by a user. Each control signal is generated at intervals so that a certain time interval is left between the generated pulses. Furthermore, the second pulse generating signal is generated within the duration of the first polarity pulse.

[0147] S1120: Based on the first pulse generating signal and the second pulse generating signal, control the pulse electric field generating device to generate a plurality of combined pulses.

[0148] In response to the first pulse generation signal and the second pulse generation signal generated successively, the first pulse generation circuit and the second pulse generation circuit successively generate a first polarity pulse and a second polarity pulse, and the duration of the first polarity pulse partially overlaps with that of the second polarity pulse to generate a combined pulse.

[0149] In some embodiments, the above-mentioned method of controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal comprises: controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal. Furthermore, there is an inter-pulse delay between any two adjacent combined pulses.

[0150] That is to say, the generated combined pulse sequence includes a plurality of combined pulses spaced apart from each other, and the time waveform of the pulse voltage is as follows: Figure 3 shown.

[0151] In some embodiments, based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to generate multiple combined pulses, including: based on the first pulse generating signal and the second pulse generating signal, the pulse electric field generating device is controlled to alternately generate multiple first polarity pulses and second polarity pulses.

[0152] Specifically, the first pulse generating signal and the second pulse generating signal are generated alternately. In response to the alternately generated first pulse generating signal and the second pulse generating signal, the first polarity pulse and the second polarity pulse are also generated alternately. Furthermore, by setting the duration and generation interval of the control signal, the pulse interval between the two first polarity pulses can be made smaller than the pulse width of the second polarity pulse. The time waveform of the pulse voltage is as shown in FIG. Fig.12 In the pulse sequence applied in this way, there is no time delay between the pulse high-pressure area and the pulse low-pressure area, which has a greater impact on the cell membrane and can further improve the pulse ablation effect.

[0153] In some embodiments, the first pulse generating signal includes a first control signal and a second control signal, and the second pulse generating signal includes a third control signal and a fourth control signal. In the above embodiments, based on the first pulse generating signal and the second pulse generating signal, controlling the pulse electric field generating device to generate a plurality of combined pulses includes: based on the first control signal and the third control signal, controlling the pulse electric field generating device to generate a plurality of first combined pulses; then, based on the second control signal and the fourth control signal, controlling the pulse electric field generating device to generate a plurality of second combined pulses.

[0154] That is to say, a plurality of first combination pulses may be continuously output first, and then a plurality of second combination pulses may be continuously output after a certain delay. Furthermore, the pulse parameters of the first combination pulse and the second combination pulse are different. Exemplarily, the pulse amplitude of the first combination pulse is greater than the pulse amplitude of the second combination pulse, and the pulse width of the first combination pulse is less than the pulse width of the second combination pulse.

[0155] In some embodiments, in the first combined pulse sequence, there is an inter-pulse delay between adjacent first combined pulses; in the second combined pulse sequence, there is also an inter-pulse delay between adjacent second combined pulses. The obtained time waveform of the pulse voltage is as shown in FIG. Fig.13 shown.

[0156] In some other embodiments, in the first combined pulse sequence, there is no inter-pulse delay between adjacent first combined pulses, and the generation method thereof is as follows: Fig.12 In the second combined pulse sequence, there is no inter-pulse delay between adjacent second combined pulses, and the generation method thereof is also as follows Fig.12In the embodiment shown in FIG. 1 , the time waveform of the pulse voltage obtained is as follows: Fig.14 shown.

[0157] It can be understood that the first and second combination pulse sequences in the above two embodiments can be replaced or combined with each other; at the same time, multiple second combination pulses can be output continuously first, and then multiple first combination pulses can be output continuously after a certain delay. The present disclosure does not make any specific restrictions on this.

[0158] Exemplarily, 10 to 200 first combination pulses may be generated first, and then 10 to 400 second combination pulses may be generated; wherein the time interval between the last first combination pulse and the first second combination pulse is 100 microseconds to hundreds of milliseconds. As a preferred embodiment, 10 to 100 first combination pulses may be generated first, and then 100 to 200 second combination pulses may be generated to obtain a better ablation effect.

[0159] In some embodiments, the above-mentioned method of controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal includes: controlling the pulse electric field generating device to generate a first combined pulse based on the first control signal and the third control signal; then, controlling the pulse electric field generating device to generate a second combined pulse based on the second control signal and the fourth control signal; and repeating the above steps until the sum of the number of the first combined pulse and the second combined pulse reaches a preset value. The preset value can be determined according to actual conditions.

[0160] In the combined pulses generated by the above embodiment, there is an inter-pulse delay between each combined pulse, and the time waveform of the obtained pulse voltage is as follows: Fig.15 shown.

[0161] In some embodiments, the above embodiments control the pulse electric field generating device to generate multiple combination pulses based on the first pulse generating signal and the second pulse generating signal, including: based on the first control signal and the third control signal, controlling the pulse electric field generating device to generate a first combination pulse; then, based on the second control signal and the fourth control signal, controlling the pulse electric field generating device to generate a second combination pulse; repeating the above steps until the sum of the number of the first combination pulses and the second combination pulses reaches a preset value; wherein the durations of two adjacent combination pulses partially overlap.

[0162] The difference between this embodiment and the previous embodiment is that there is no inter-pulse delay between each combination pulse, and the rear end of the previous combination pulse overlaps with the front end of the next combination pulse. The time waveform of the pulse voltage is as shown in FIG. Fig.16 shown.

[0163] Fig.17FIG. 1 is a flow chart of a pulse application method provided by an embodiment of the present disclosure, such as Fig.17 As shown, the pulse application method provided by the embodiment of the present disclosure includes the following steps.

[0164] S1710, setting at least two applicators in the pulse electric field generating device at the target position.

[0165] The target position refers to the range of the electric field action area that the user expects the pulse electric field generator to generate. For example, the target position may refer to the area near the tumor cells. When the pulse electric field generator is working, the generated electric field action area can cover all or most of the tumor cells.

[0166] S1720, select any two application members from at least two application members.

[0167] S1730, applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members in sequence.

[0168] When the first polarity pulse generated by the first pulse generating circuit and the second polarity pulse generated by the second pulse generating circuit are applied successively to any two applicators, the specific application methods of the two applicators can be set respectively so that at least two electric field action areas can be simultaneously formed within the preset range of the applicator group to expand the ablation intensity and ablation range.

[0169] Several specific implementation methods of pulse application are introduced below to generate electric field action areas with different ranges and ablation intensities.

[0170] In some embodiments, the above-mentioned application member group includes a first application member and a second application member; the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area.

[0171] The method of applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two application members in sequence includes: applying the first polarity pulse to the first pulse application area; applying the second polarity pulse to the third pulse application area; and at the same time, the voltage of the second pulse application area and the fourth pulse application area is 0V. The electric field action area generated by the method of this embodiment is as follows: Figures 5a to 5c shown.

[0172] In other embodiments, the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device are applied to any two application members in sequence, including: applying the first polarity pulse and the second polarity pulse to the first pulse application area and the second pulse application area respectively; applying the first polarity pulse or the second polarity pulse to the third pulse application area; and at the same time, the voltage of the fourth pulse application area is 0V. The electric field action area generated by the method of this embodiment is as follows: Figure 6 shown.

[0173] In some other embodiments, the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device are applied to any two application members in sequence, including: synchronously applying the first polarity pulse to the first pulse application area and the third pulse application area; synchronously applying the second polarity pulse to the second pulse application area and the fourth pulse application area. The electric field action area generated by the method of this embodiment is as follows: Figure 7 shown.

[0174] Compared with the single electric field action area in the related art, the pulse application method provided by the embodiment of the present disclosure has a larger ablation range and a stronger ablation force. At the same time, compared with the method of alternately outputting the first polarity pulse and the second polarity pulse, or sequentially outputting the unipolar pulse in the related art, the method in the present disclosure can directly reduce the voltage value requirement by half, and the high voltage resistance and insulation requirements of the system components can also be reduced by half, reducing the overall cost of the device, while improving the ablation effect of the pulse.

[0175] Those skilled in the art will appreciate that aspects of the present disclosure may be implemented as systems, methods or program products. When the program product is run on a terminal device such as a pulse electric field generator or a host computer, the program code is used to enable the terminal device to execute the steps of various exemplary embodiments of the present disclosure described in the above method embodiment section of this specification.

[0176] Those skilled in the art will readily appreciate other embodiments of the present disclosure after considering the specification and practicing the invention disclosed herein. The present disclosure is intended to cover any variations, uses or adaptations of the present disclosure, which follow the general principles of the present disclosure and include common knowledge or customary techniques in the art that are not disclosed in the present disclosure. The description and examples are intended to be exemplary only, and the true scope and spirit of the present disclosure are indicated by the appended claims.

Claims

1. A pulse electric field generating device, characterized in that: include: A first pulse generating circuit, used for generating a first polarity pulse; A second pulse generating circuit, used for generating a second polarity pulse; At least one application member, the first pulse generating circuit and the second pulse generating circuit are both connected to the application member, and in a working state, the first polarity pulse and the second polarity pulse are both applied to any one of the at least one application member; The polarities of the first polarity pulse and the second polarity pulse are opposite, and the durations of the first polarity pulse and the second polarity pulse partially overlap.

2. A pulse electric field generating device, characterized in that: include: A first pulse generating circuit, used for generating a first polarity pulse; A second pulse generating circuit, used for generating a second polarity pulse; At least two applying members, the first pulse generating circuit and the second pulse generating circuit are respectively connected to at least one applying member, for outputting a first polarity pulse and a second polarity pulse; The polarities of the first polarity pulse and the second polarity pulse are opposite, and the durations of the first polarity pulse and the second polarity pulse partially overlap.

3. The pulse electric field generating device according to claim 2, characterized in that: Any two application members that respectively apply pulses of different polarities constitute an application member group, and at least two electric field action areas are formed within a preset range of the application member group.

4. The pulse electric field generating device according to claim 3, characterized in that: In the group of application elements, at least one application element has at least two pulse application zones.

5. The pulse electric field generating device according to claim 3, characterized in that: The application member group includes a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area.

6. The pulse electric field generating device according to claim 5, characterized in that: The first pulse application area is connected to the first pulse generating circuit, and is used to output the first polarity pulse generated by the first pulse generating circuit. The third pulse application area is connected to the second pulse generating circuit, and is used to output the second polarity pulse generated by the second pulse generating circuit. Moreover, the voltage of the second pulse application area and the fourth pulse application area is zero.

7. The pulse electric field generating device according to claim 5, characterized in that: The first pulse application area and the third pulse application area are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, and the second pulse application area and the fourth pulse application area are connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit.

8. The pulse electric field generating device according to claim 5, characterized in that: The first pulse application area and the third pulse application area are connected to the first pulse generating circuit for outputting the first polarity pulse generated by the first pulse generating circuit, the second pulse application area is connected to the second pulse generating circuit for outputting the second polarity pulse generated by the second pulse generating circuit, and the voltage of the fourth pulse application area is zero.

9. The pulse electric field generating device according to claim 2, characterized in that: The first pulse generating circuit comprises: a first pulse generating module and a second pulse generating module, the first pulse generating module is used to generate a first electric pulse, and the second pulse generating module is used to generate a second electric pulse, wherein the pulse parameters of the first electric pulse and the second electric pulse are different; The second pulse generating circuit includes: a third pulse generating module and a fourth pulse generating module, the third pulse generating module is used to generate a third electrical pulse, and the fourth pulse generating module is used to generate a fourth electrical pulse, wherein the pulse parameters of the third electrical pulse and the fourth electrical pulse are different.

10. The pulse electric field generating device according to claim 9, characterized in that: The pulse parameters include at least one of a pulse amplitude and a pulse width.

11. The pulse electric field generating device according to claim 9, characterized in that: The first electric pulse and the third electric pulse have equal pulse amplitudes and pulse widths, opposite polarities, and partially overlap in duration; and, The second electric pulse and the fourth electric pulse have equal pulse amplitudes and pulse widths, opposite polarities, and partially overlap in duration.

12. The pulse electric field generating device according to claim 9, characterized in that: The pulse amplitude of the first electric pulse is greater than the pulse amplitude of the second electric pulse, and the pulse width of the first electric pulse is smaller than the pulse width of the second electric pulse.

13. The pulse electric field generating device according to claim 9, characterized in that: The pulse width of the first electric pulse is in nanosecond order, and the pulse amplitude is 6000V-8000V; the pulse width of the second electric pulse is in microsecond order, and the pulse amplitude is 1000V-5000V.

14. The pulse electric field generating device according to claim 2, characterized in that: Each of the applying elements is connected to at least one of the first pulse generating circuit and the second pulse generating circuit.

15. A pulse electric field generating device, characterized in that: include: The pulse electric field generating device according to any one of claims 1 to 14; as well as A control module, connected to the first pulse generating circuit and the second pulse generating circuit in the pulse electric field generating device, respectively, for generating a first pulse generating signal and a second pulse generating signal; Among them, the first pulse generating signal is at least used to control the first pulse generating circuit to generate a first polarity pulse, and the second pulse generating signal is at least used to control the second pulse generating circuit to generate a second polarity pulse, the polarity of the first polarity pulse and the second polarity pulse are opposite, and the duration of the first polarity pulse and the second polarity pulse partially overlap, so that the first polarity pulse and the second polarity pulse are successively applied to the application element in the pulse electric field generating device.

16. The pulse electric field generating device according to claim 15, characterized in that: The invention also includes a switching module for switching the first polarity pulse and the second polarity pulse to be transmitted to different application members.

17. A pulse crossing control method, characterized in that: Applied to the pulse electric field generating device of claim 15, the method comprises: Get input information; Based on the input information, generate a first pulse generation signal; Based on the first pulse generating signal, controlling the first pulse generating circuit of the pulse electric field generating device to generate a first polarity pulse; generating a second pulse generation signal based on the input information within the duration of the first electrical pulse; Based on the second pulse generating signal, the second pulse generating circuit of the pulse electric field generating device is controlled to generate a second polarity pulse, wherein the polarities of the first polarity pulse and the second polarity pulse are opposite, and the durations of the first polarity pulse and the second polarity pulse partially overlap.

18. A method for generating a pulse electric field, characterized in that: A pulse electric field generating device as claimed in any one of claims 1 to 14; The method comprises: Acquire a first pulse generation signal and a second pulse generation signal, wherein the second pulse generation signal is generated within a duration of the first pulse generation signal; Based on the first pulse generating signal and the second pulse generating signal, controlling the pulse electric field generating device to generate a plurality of combined pulses; Each combined pulse includes a first polarity pulse and a second polarity pulse, the first polarity pulse and the second polarity pulse have opposite polarities, and the durations of the first polarity pulse and the second polarity pulse partially overlap.

19. The pulse electric field generating method according to claim 18, characterized in that: The step of controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal comprises: Based on the first pulse generation signal and the second pulse generation signal, the pulse electric field generation device is controlled to generate a plurality of the combination pulses, and there is an inter-pulse delay between two adjacent combination pulses.

20. The pulse electric field generating method according to claim 18, characterized in that: The step of controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal comprises: Based on the first pulse generation signal and the second pulse generation signal, controlling the pulse electric field generation device to alternately generate a plurality of first polarity pulses and second polarity pulses; Wherein, the pulse interval of the first polarity pulse is smaller than the pulse width of the second polarity pulse.

21. The pulse electric field generating method according to claim 18, characterized in that: The first pulse generation signal includes a first control signal and a second control signal, and the second pulse generation signal includes a third control signal and a fourth control signal. The step of controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal comprises: Based on the first control signal and the third control signal, control the pulse electric field generating device to generate a plurality of first combined pulses; Based on the second control signal and the fourth control signal, control the pulse electric field generating device to generate a plurality of second combined pulses; The pulse parameters of the first combined pulse and the second combined pulse are different.

22. The pulse electric field generating method according to claim 18, characterized in that: The first pulse generation signal includes a first control signal and a second control signal, and the second pulse generation signal includes a third control signal and a fourth control signal. The step of controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal comprises: Based on the first control signal and the third control signal, control the pulse electric field generating device to generate a first combined pulse; Based on the second control signal and the fourth control signal, control the pulse electric field generating device to generate a second combined pulse; Repeat the above steps until the sum of the number of the first combined pulses and the number of the second combined pulses reaches a preset value; There is an inter-pulse delay between two adjacent combined pulses.

23. The pulse electric field generating method according to claim 18, characterized in that: The first pulse generation signal includes a first control signal and a second control signal, and the second pulse generation signal includes a third control signal and a fourth control signal. The step of controlling the pulse electric field generating device to generate a plurality of combined pulses based on the first pulse generating signal and the second pulse generating signal comprises: Based on the first control signal and the third control signal, control the pulse electric field generating device to generate a first combined pulse; Based on the second control signal and the fourth control signal, control the pulse electric field generating device to generate a second combined pulse; Repeat the above steps until the sum of the number of the first combined pulses and the number of the second combined pulses reaches a preset value; The durations of two adjacent combined pulses partially overlap.

24. A pulse application method, characterized in that: A pulse electric field generating device as claimed in any one of claims 2 to 14; The method comprises: placing at least two application members in the pulse electric field generating device at a target position; Selecting any two application members from the at least two application members; Applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members successively; The polarities of the first polarity pulse and the second polarity pulse are opposite, and the durations of the first polarity pulse and the second polarity pulse partially overlap.

25. The pulse applying method according to claim 24, characterized in that: The any two application members include a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area; The step of applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members in sequence comprises: applying the first polarity pulse to the first pulse application area; applying the second polarity pulse to the third pulse application area; Wherein, the voltages of the second pulse application area and the fourth pulse application area are zero.

26. The pulse application method according to claim 24, characterized in that: The any two application members include a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area; The step of applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members in sequence comprises: applying the first polarity pulse and the second polarity pulse to the first pulse application area and the second pulse application area respectively; applying the first polarity pulse or the second polarity pulse to the third pulse applying area; Wherein, the voltage of the fourth pulse application area is zero.

27. The pulse applying method according to claim 24, characterized in that: The any two application members include a first application member and a second application member, the first application member includes a first pulse application area and a second pulse application area, and the second application member includes a third pulse application area and a fourth pulse application area; The step of applying the first polarity pulse and the second polarity pulse generated by the pulse electric field generating device to any two applying members in sequence comprises: applying the first polarity pulse synchronously to the first pulse application area and the third pulse application area; The second polarity pulse is synchronously applied to the second pulse application area and the fourth pulse application area.

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