Penetration promoting composition of anti-wrinkle and firming active substances and anti-wrinkle and firming cosmetic

Abstract

The invention provides a permeation promoting composition of anti-wrinkle and firming active substances and an anti-wrinkle and firming cosmetic. The permeation-promoting composition of the anti-wrinkle and firming active substances comprises the anti-wrinkle and firming active substances, wherein the anti-wrinkle and firming active substances comprise one or more of arginine / lysine polypeptide, tripeptide-1 copper and a sturgeon roe extract; the penetration promoting composition is prepared from 1, 2-pentanediol, inositol and sodium surfactin. According to the invention, the permeation of anti-wrinkle and firming active substances can be promoted, the addition amount of the anti-wrinkle and firming active substances in cosmetics can be reduced, and the production cost can be reduced. And the obtained anti-wrinkle and firming cosmetic can better inhibit the expression of MMP-9, promote the expression of type I collagen and reduce the wrinkle area.

Description

Technical Field

[0001] The present application belongs to the technical field of cosmetics, and specifically relates to a penetration-promoting composition of anti-wrinkle and firming active substances and anti-wrinkle and firming cosmetics. Background Art

[0002] As people's living standards improve, they pay more and more attention to their skin. Cosmetics are a type of substance used on the skin to maintain the skin. There are many types of cosmetics, which can be classified by function into moisturizing, acne removal, redness removal, anti-aging, whitening or sun protection, etc. Among them, anti-aging products are more popular among middle-aged people.

[0003] Anti-wrinkle and firming is a major function of anti-aging products. Some existing lifting and firming cosmetics use a high proportion of macromolecular film-forming agents, fillers, or are used with instruments or lifting and firming membranes to allow consumers to feel the tightening and lifting effect, but the durability is poor. Or they add a high proportion of polypeptide active ingredients, but the production cost is high and the cost performance is low. Summary of the invention

[0004] The present application provides a penetration-promoting composition of an anti-wrinkle and firming active substance and an anti-wrinkle and firming cosmetic, which can promote the penetration of the anti-wrinkle and firming active substance, reduce the amount of the anti-wrinkle and firming active substance added to the cosmetic, and help reduce production costs.

[0005] The first aspect of the present application provides a penetration-promoting composition of an anti-wrinkle and firming active substance, comprising:

[0006] Anti-wrinkle and firming active ingredients, including one or more of arginine / lysine peptide, tripeptide-1 copper and sturgeon roe extract;

[0007] A penetration enhancing composition comprising 1,2-pentanediol, inositol and sodium subtilisin.

[0008] In a feasible embodiment of the first aspect of the present application, the penetration-enhancing composition comprises 1,2-pentanediol, inositol and sodium subtilisin in a mass ratio of (1-5):(0.2-1):1.

[0009] In a feasible implementation of the first aspect of the present application, the anti-wrinkle and firming active substances include arginine / lysine polypeptide, tripeptide-1 copper and sturgeon roe extract in a mass ratio of (1-5):(0.05-1):5.

[0010] In a feasible implementation of the first aspect of the present application, the anti-wrinkle and firming active substances further include one or more of acetyl hexapeptide-8, potassium cocoyl hydrolyzed collagen, and dipeptide diaminobutyrylbenzamide diacetate.

[0011] The second aspect of the present application provides an anti-wrinkle and firming cosmetic, comprising the penetration-promoting composition of the anti-wrinkle and firming active substance provided in the first aspect of the present application.

[0012] In a feasible implementation of the second aspect of the present application, taking the total weight content of the anti-wrinkle and firming cosmetic as 100% as a benchmark, the anti-wrinkle and firming cosmetic includes the following weight contents of components:

[0013] 2% to 10% of a penetration-enhancing composition, comprising 1,2-pentanediol, inositol and sodium subtilisin;

[0014] 5% to 30% anti-wrinkle and firming active ingredients, including arginine / lysine peptides, tripeptide-1 copper, and sturgeon roe extract;

[0015] 5% to 10% additives and 65% to 85% water.

[0016] In a feasible implementation of the second aspect of the present application, based on the total mass content of the anti-wrinkle and firming cosmetics as 100%, the penetration-promoting composition includes: 1% to 9% of 1,2-pentanediol, 0.1% to 5% of inositol, and 0.1% to 5% of sodium subtilisin.

[0017] Optional 1,2-pentanediol 1% to 5%, inositol 0.1% to 0.5%, and subtilisin sodium 0.2% to 1%.

[0018] In a feasible implementation manner of the second aspect of the present application, based on the total mass content of the anti-wrinkle and firming cosmetics as 100%, the anti-wrinkle and firming active substances include: arginine / lysine polypeptide 1% to 5%, tripeptide-1 copper 0.05% to 1%, sturgeon roe extract 3% to 6%, acetyl hexapeptide-8 0.2% to 2%, cocoyl hydrolyzed collagen potassium 1% to 4%, and dipeptide diaminobutyrylbenzamide diacetate 0.2% to 2%.

[0019] In a feasible implementation of the second aspect of the present application, the auxiliary agent includes one or more of a thickener, a humectant, a preservative and a pH adjuster;

[0020] Optionally, the thickener includes one or more of carbomer, xanthan gum, sodium alginate and gum arabic;

[0021] Optionally, the humectant includes one or more of 1,3-propylene glycol, glycerol, butylene glycol and dipropylene glycol;

[0022] Optionally, the preservative includes one or more of p-hydroxyacetophenone, 1,2-hexanediol, phenoxyethanol and benzyl alcohol;

[0023] Optionally, the pH adjuster includes one or more of arginine, serine and glutamic acid.

[0024] In a feasible implementation manner of the second aspect of the present application, based on the total mass content of the anti-wrinkle and firming cosmetics as 100%, the anti-wrinkle and firming cosmetics include the following components by mass: 0.05% to 1% carbopol gum, 0.05% to 1% xanthan gum, 2% to 8% 1,3-propylene glycol, 0.5% to 2.0% parahydroxyacetophenone, 0.5% to 2.0% 1,2-hexanediol, 1% to 5% arginine / lysine polypeptide, 0.05% to 1% tripeptide-1 copper, 3% to 6% sturgeon roe extract, 0.2% to 2% acetyl hexapeptide-8, 1% to 4% cocoyl hydrolyzed collagen potassium, 0.2% to 2% dipeptide diaminobutyrylbenzylamide diacetate, 1% to 5% 1,2-pentanediol, 0.1% to 0.5% inositol, 0.2% to 1% sodium subtilisin, 1% to 5% arginine and 65% to 85% water. DETAILED DESCRIPTION

[0025] In order to make the invention purpose, technical scheme and beneficial technical effect of the present application clearer, the present application is further described in detail below in conjunction with the embodiments. It should be understood that the embodiments described in this specification are only for explaining the present application, not for limiting the present application.

[0026] For simplicity, only some numerical ranges are explicitly disclosed herein. However, any lower limit can be combined with any upper limit to form an unambiguous range; and any lower limit can be combined with other lower limits to form an unambiguous range, and any upper limit can be combined with any other upper limit to form an unambiguous range. In addition, although not explicitly stated, each point or single value between the range endpoints is included in the range. Thus, each point or single value can be combined with any other point or single value as its own lower limit or upper limit or with other lower limits or upper limits to form an unambiguous range.

[0027] In the description herein, when a composition is described as containing, comprising or including specific components, or when a process is described as containing, comprising or including specific process steps, it is expected that the composition of the present application also consists essentially of or consists of the components, and the process of the present application also consists essentially of or consists of the process steps.

[0028] The use of the terms "including," "comprising," "containing," and "having" should generally be interpreted as open ended and non-limiting unless expressly stated otherwise.

[0029] In the description of this article, it should be noted that, unless otherwise specified, “above” and “below” are inclusive of the number itself, and the “multiple” in “one or more” means more than two.

[0030] The above-mentioned summary of the invention of the present application is not intended to describe each disclosed embodiment or each implementation in the present application. The following description more specifically illustrates exemplary embodiments. In many places throughout the application, guidance is provided by a series of examples, which can be used in various combinations. In each example, enumeration is only used as a representative group and should not be interpreted as exhaustive.

[0031] The present application provides a penetration-promoting composition of an anti-wrinkle and firming active substance and an anti-wrinkle and firming cosmetic, which can promote the penetration of the anti-wrinkle and firming active substance and improve its utilization rate, thereby reducing the amount of the anti-wrinkle and firming active substance added to the cosmetic, which is conducive to reducing production costs.

[0032] In an embodiment of the first aspect of the present application, a penetration-promoting composition of an anti-wrinkle and firming active substance is provided, comprising:

[0033] Anti-wrinkle and firming active ingredients, including one or more of arginine / lysine peptide, tripeptide-1 copper and sturgeon roe extract;

[0034] A penetration enhancing composition comprising 1,2-pentanediol, inositol and sodium subtilisin.

[0035] The anti-wrinkle and firming active substances of the present application include arginine / lysine polypeptide, tripeptide-1 copper and sturgeon roe extract, which have good water solubility. The penetration-promoting composition of the present application can soften the skin surface, reduce the resistance of the stratum corneum to the anti-wrinkle and firming active substances, reduce the surface tension of water, enhance the hydrophilicity of the skin, improve the osmotic pressure environment, and facilitate the penetration of the anti-wrinkle and firming active substances into the skin, thereby improving their utilization rate, thereby reducing the amount of anti-wrinkle and firming active substances added to cosmetics, and helping to reduce production costs. When applied to anti-wrinkle and firming cosmetics, it can inhibit the expression of MMP-9, promote the expression of type I collagen, and reduce the area of ​​wrinkles.

[0036] In some embodiments, the penetration enhancing composition comprises 1,2-pentanediol, inositol and subtilisin sodium in a mass ratio of (1-5):(0.2-1):1.

[0037] When the penetration-promoting compounds within the above mass ratio range are applied to cosmetics, they can better promote the penetration of anti-wrinkle and firming active substances. When applied to cosmetics, they can inhibit the expression of MMP-9, promote the expression of type I collagen, and reduce the area of ​​wrinkles.

[0038] In some embodiments, the anti-wrinkle and firming active substance includes arginine / lysine polypeptide, tripeptide-1 copper and sturgeon roe extract in a mass ratio of (1-5):(0.05-1):5.

[0039] The anti-wrinkle and firming active substances within the above mass ratio range are more effectively combined with the penetration-enhancing composition.

[0040] In some embodiments, the anti-wrinkle and firming active substance further comprises one or more of acetyl hexapeptide-8, potassium cocoyl hydrolyzed collagen, and dipeptide diaminobutyryl benzylamide diacetate.

[0041] In an embodiment of the second aspect of the present application, a penetration-promoting composition is provided, which includes the anti-wrinkle and firming active substance provided in the first aspect of the present application.

[0042] In some embodiments, the anti-wrinkle and firming cosmetic comprises the following components by weight, based on the total weight of the anti-wrinkle and firming cosmetic being 100%:

[0043] 2% to 10% of a penetration-enhancing composition, comprising 1,2-pentanediol, inositol and sodium subtilisin;

[0044] 5% to 30% anti-wrinkle and firming active ingredients, including arginine / lysine peptides, tripeptide-1 copper, and sturgeon roe extract;

[0045] 5% to 10% additives and 65% to 85% water.

[0046] In a feasible implementation of the second aspect of the present application, based on the total mass content of the anti-wrinkle and firming cosmetics as 100%, the penetration-promoting composition includes: 1% to 9% of 1,2-pentanediol, 0.1% to 5% of inositol, and 0.1% to 5% of sodium subtilisin.

[0047] Optional 1,2-pentanediol 1% to 5%, inositol 0.1% to 0.5%, and subtilisin sodium 0.2% to 1%.

[0048] In some embodiments, based on the total mass content of the anti-wrinkle and firming cosmetics as 100%, the anti-wrinkle and firming active substances include: arginine / lysine polypeptide 1% to 5%, tripeptide-1 copper 0.05% to 1%, sturgeon roe extract 3% to 6%, acetyl hexapeptide-8 0.2% to 2%, cocoyl hydrolyzed collagen potassium 1% to 4%, and dipeptide diaminobutyrylbenzamide diacetate 0.2% to 2%.

[0049] The anti-wrinkle and firming cosmetics of the present application can inhibit the expression of MMP-9, promote the expression of type I collagen, reduce the area of ​​wrinkles, have low production costs, and are highly cost-effective.

[0050] In this application, arginine / lysine polypeptide, acetyl hexapeptide-8, cocoyl hydrolyzed collagen potassium, and dipeptide diaminobutyryl benzylamide diacetate refer to the raw material INCI name, which may be an aqueous solution containing these substances. The mass content of the above substances in this application may refer to the content of the solution containing the above substances.

[0051] For example, the present application contains 1% to 5% arginine / lysine polypeptide, 0.2% to 2% acetyl hexapeptide-8, 1% to 4% potassium cocoyl hydrolyzed collagen, and 0.2% to 2% dipeptide diaminobutyrylbenzamide diacetate. It can be 1% to 5% arginine / lysine polypeptide solution (whose active substance concentration is 50ppm), 0.2% to 2% acetyl hexapeptide-8 solution (whose active substance concentration is 500ppm), 1% to 4% potassium cocoyl hydrolyzed collagen solution (whose active substance concentration is 1000ppm), and 0.2% to 2% dipeptide diaminobutyrylbenzamide diacetate solution (whose active substance concentration is 100ppm).

[0052] In some embodiments, the auxiliary agent includes one or more of a thickener, a humectant, a preservative, and a pH adjuster;

[0053] Optionally, the thickener includes one or more of carbomer, xanthan gum, sodium alginate and gum arabic;

[0054] Optionally, the humectant includes one or more of 1,3-propylene glycol, glycerol, butylene glycol and dipropylene glycol;

[0055] Optionally, the preservative includes one or more of p-hydroxyacetophenone, 1,2-hexanediol, phenoxyethanol and benzyl alcohol;

[0056] Optionally, the pH adjuster includes one or more of arginine, serine and glutamic acid.

[0057] In some embodiments, based on the total mass content of the anti-wrinkle and firming cosmetics as 100%, the anti-wrinkle and firming cosmetics include the following components by mass: 0.05% to 1% carbomer, 0.05% to 1% xanthan gum, 2% to 8% 1,3-propylene glycol, 0.5% to 2.0% parahydroxyacetophenone, 0.5% to 2.0% 1,2-hexanediol, 1% to 5% arginine / lysine polypeptide, 0.05% to 1% tripeptide-1 copper, 3% to 6% sturgeon roe extract, 0.2% to 2% acetyl hexapeptide-8, 1% to 4% cocoyl hydrolyzed collagen potassium, 0.2% to 2% dipeptide diaminobutyrylbenzylamide diacetate, 1% to 5% 1,2-pentanediol, 0.1% to 0.5% inositol, 0.2% to 1% sodium subtilisin, 1% to 5% arginine and 65% to 85% water.

[0058] In some embodiments, a method for preparing an anti-wrinkle and firming cosmetic comprises:

[0059] Mix water, carbomer, xanthan gum, 1,3-propylene glycol, p-hydroxyacetophenone and 1,2-hexanediol to obtain a phase A solution;

[0060] Acetyl hexapeptide-8 (500 ppm), arginine / lysine polypeptide (500 ppm), cocoyl hydrolyzed collagen potassium (1000 ppm), tripeptide-1 copper, dipeptide diaminobutyrylbenzylamide diacetate (100 ppm), and sturgeon roe extract were mixed to obtain a phase B solution;

[0061] Mix 1,2-pentanediol, inositol, sodium subtilisin and arginine to obtain a phase C solution;

[0062] The phase A solution, the phase B solution and the phase C solution are mixed and stirred to obtain an anti-wrinkle and firming cosmetic.

[0063] Example

[0064] The following examples more specifically describe the disclosure of the present application, which are intended for illustrative purposes only, as it will be apparent to those skilled in the art that various modifications and variations are possible within the scope of the disclosure of the present application. Unless otherwise stated, all parts, percentages, and ratios reported in the following examples are by weight, and all reagents used in the examples are commercially available or synthesized according to conventional methods and can be used directly without further processing, and the instruments used in the examples are commercially available.

[0065] Example 1

[0066] An anti-wrinkle and firming cosmetic comprises the following components in percentage by mass: phase A: 78.9% of water, 0.1% of carbomer, 0.1% of xanthan gum, 5% of 1,3-propylene glycol, 0.5% of p-hydroxyacetophenone, and 0.5% of 1,2-hexanediol; phase B: 1% of acetyl hexapeptide-8 (500ppm), 2% of arginine / lysine polypeptide (500ppm), 3% of cocoyl hydrolyzed collagen potassium (1000ppm), 0.1% of tripeptide-1 copper, 1% of dipeptide diaminobutyrylbenzamide diacetate (100ppm), and 5% of sturgeon roe extract; phase C: 2% of 1,2-pentanediol, 0.2% of inositol, 0.5% of sodium subtilisin, and 0.1% of arginine.

[0067] A method for preparing anti-wrinkle and firming cosmetics, comprising:

[0068] Mix water, carbomer, xanthan gum, 1,3-propylene glycol, p-hydroxyacetophenone and 1,2-hexanediol to obtain a phase A solution;

[0069] Acetyl hexapeptide-8 (500 ppm), arginine / lysine polypeptide (500 ppm), cocoyl hydrolyzed collagen potassium (1000 ppm), tripeptide-1 copper, dipeptide diaminobutyrylbenzylamide diacetate (100 ppm) and sturgeon roe extract were mixed to obtain a phase B solution;

[0070] Mix 1,2-pentanediol, inositol, sodium subtilisin and arginine to obtain a phase C solution;

[0071] The phase A solution, the phase B solution and the phase C solution are mixed and stirred to obtain an anti-wrinkle and firming cosmetic.

[0072] Embodiments 2 to 16

[0073] The difference between Examples 2 to 7 and Example 1 is that the penetration-promoting composition is changed. The specific parameters of the changes are shown in Table 1.

[0074] Compared with Example 1, Examples 8 to 16 differ in that the anti-wrinkle and firming active ingredients are changed. The specific parameters of the changes are shown in Table 1.

[0075] Comparative Examples 1 to 6

[0076] Comparative Examples 1 to 3 are different from Example 1 in that only two of them are added to the penetration-promoting composition, and the specific parameters of the changes are shown in Table 1.

[0077] Comparative Examples 4 to 6 are different from Example 1 in that the types of penetration-promoting compositions are replaced. The replaced types are shown in Table 1.

[0078] Test Section

[0079] 30 volunteers were recruited and the product was applied on the skin; after the data was processed, the MMP-9 inhibition rate, the expression level of type I collagen, the wrinkle area, etc. were tested.

[0080] Matrix metalloproteinase (MMP-9) activity test

[0081] A 3D skin model was constructed to simulate the skin structure, and UVA was used to stimulate HDF-α cells. Then, the same amount of the samples of the embodiment and the comparative example were dripped into different culture dishes, and one of them was not dripped with samples, as a blank control group, and cultured. After the same period of culture, the expression level of MMP-9 (matrix metalloproteinase) in mRNA was detected. The test results are shown in Table 2, and some are plotted as bar graphs.

[0082] Dermal collagen expression test

[0083] A 3D skin model was constructed to simulate the skin structure, and UVA was used to stimulate HDF-α cells. Then, the same amount of the example and comparative example samples were added to different culture dishes, and a blank control group was not irradiated with UVA and no sample was added for culture. After the same period of culture, the expression level of COL1 (type I collagen) in the mRNA of the HDF-α in the culture dish for UVA-damaged dermal fibroblasts was detected. The test results are shown in Table 2, and some are drawn into bar graphs.

[0084] Wrinkle area change test

[0085] 100 volunteers were recruited, and the samples of each embodiment and comparative example were applied to the skin of the wrinkle area of ​​the face, and the wrinkle areas were tested at three time points: before use (D0), 14 days after use (D14), and 28 days after use (D28).

[0086] Table 1:

[0087]

[0088]

[0089] Table 2:

[0090]

[0091] As can be seen from the table, the examples of the present application can significantly inhibit the expression level of MMP-9 (matrix metalloproteinase) in UVA damaged dermal fibroblasts in mRNA, promote the expression level of HDF-α in UVA damaged dermal fibroblasts in COL1 (type I collagen) in mRNA, and reduce the wrinkle area. It can be seen that the composition of the present application can promote the penetration of anti-wrinkle and firming active substances and improve the anti-wrinkle effect of anti-wrinkle and firming cosmetics. Among them, Example 1 has a better improvement effect and a better cost-effectiveness by rationally configuring the composition and ratio of the penetration-promoting composition and the anti-wrinkle and firming composition.

[0092] The above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the embodiments here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the claims of the present invention.

Claims

1. A penetration-promoting composition of an anti-wrinkle and firming active substance, characterized in that: The penetration-promoting composition of the anti-wrinkle and firming active substance comprises: Anti-wrinkle and firming active ingredients, including one or more of arginine / lysine peptide, tripeptide-1 copper and sturgeon roe extract; A penetration enhancing composition comprising 1,2-pentanediol, inositol and sodium subtilisin.

2. The penetration-promoting composition of anti-wrinkle and firming active substances according to claim 1, characterized in that: The penetration-promoting composition comprises 1,2-pentanediol, inositol and subtilisin sodium in a mass ratio of (1-5):(0.2-1):

1.

3. The penetration-promoting composition of anti-wrinkle and firming active substances according to claim 1, characterized in that: The anti-wrinkle and firming active substance comprises arginine / lysine polypeptide, tripeptide-1 copper and sturgeon roe extract in a mass ratio of (1-5):(0.05-1):

5.

4. The penetration-promoting composition of anti-wrinkle and firming active substances according to claim 1, characterized in that: The anti-wrinkle and firming active substances also include one or more of acetyl hexapeptide-8, potassium cocoyl hydrolyzed collagen, and dipeptide diaminobutyrylbenzamide diacetate.

5. An anti-wrinkle and firming cosmetic, characterized in that: A penetration-promoting composition comprising the anti-wrinkle and firming active substance according to any one of claims 1 to 4.

6. The anti-wrinkle and firming cosmetic according to claim 5, characterized in that: Taking the total mass content of the anti-wrinkle and firming cosmetic as 100% as a basis, the anti-wrinkle and firming cosmetic includes the following components in mass content: The penetration-promoting composition, 2% to 10%, includes 1,2-pentanediol, inositol and sodium subtilisin; The anti-wrinkle and firming active substances are 5% to 30%, including arginine / lysine polypeptide, tripeptide-1 copper and sturgeon roe extract; 5% to 10% additives and 65% to 85% water.

7. The anti-wrinkle and firming cosmetic according to claim 5, characterized in that: Taking the total weight content of the anti-wrinkle and firming cosmetic as 100% as a benchmark, the penetration-promoting composition comprises: 1% to 9% of 1,2-pentanediol, 0.1% to 5% of inositol, and 0.1% to 5% of sodium subtilisin. Optional 1,2-pentanediol 1% to 5%, inositol 0.1% to 0.5%, and subtilisin sodium 0.2% to 1%.

8. The anti-wrinkle and firming cosmetic according to claim 5, characterized in that: Taking the total mass content of the anti-wrinkle and firming cosmetics as 100%, the anti-wrinkle and firming active substances include: 1% to 5% arginine / lysine polypeptide, 0.05% to 1% tripeptide-1 copper, 3% to 6% sturgeon roe extract, 0.2% to 2% acetyl hexapeptide-8, 1% to 4% cocoyl hydrolyzed collagen potassium, and 0.2% to 2% dipeptide diaminobutyrylbenzamide diacetate.

9. The anti-wrinkle and firming cosmetic according to claim 6, characterized in that: The auxiliary agent includes one or more of a thickener, a moisturizer, a preservative and a pH adjuster; Optionally, the thickener includes one or more of carbomer, xanthan gum, sodium alginate and gum arabic; Optionally, the moisturizer includes one or more of 1,3-propylene glycol, glycerol, butylene glycol and dipropylene glycol; Optionally, the preservative includes one or more of p-hydroxyacetophenone, 1,2-hexanediol, phenoxyethanol and benzyl alcohol; Optionally, the pH adjuster includes one or more of arginine, serine and glutamic acid.

10. The anti-wrinkle and firming cosmetic according to claim 5, characterized in that: Taking the total mass content of the anti-wrinkle and firming cosmetic as 100%, the anti-wrinkle and firming cosmetic includes the following components in mass content: 0.05% to 1% of carbopol gum, 0.05% to 1% of xanthan gum, 2% to 8% of 1,3-propylene glycol, 0.5% to 2.0% of p-hydroxyacetophenone, 0.5% to 2.0% of 1,2-hexanediol, 1% to 5% of arginine / lysine polypeptide, 0.05% to 1% of tripeptide-1 copper, 3% to 6% of sturgeon roe extract, 0.2% to 2% of acetyl hexapeptide-8, 1% to 4% of cocoyl hydrolyzed collagen potassium, 0.2% to 2% of dipeptide diaminobutyrylbenzylamide diacetate, 1% to 5% of 1,2-pentanediol, 0.1% to 0.5% of inositol, 0.2% to 1% of sodium subtilisin, 1% to 5% of arginine and 65% to 85% of water.

Images