Gel for particle dispersion, gel for particle dispersion, method for producing gel for particle dispersion, and method for producing gel for particle dispersion

Abstract

A gel for particle dispersion, which contains a polymer (A) and a solvent (B) and is capable of dispersing particles therein, and which is characterized in that the polymer (A) forms a three-dimensional mesh structure, the solvent (B) is contained in the mesh structure, and the solvent (B) contains a polyol compound (B1).

Description

Technical Field

[0001] The present invention relates to a particle dispersion gel, a particle dispersion gel, a method for producing a particle dispersion gel, and a method for producing a particle dispersion gel. Background Art

[0002] The gel having a three-dimensional network structure can contain various particles inside.

[0003] As a technology related to such a gel for particle dispersion, for example, the technology described in Patent Document 1 (Japanese Patent Application Laid-Open No. 2018-115140) can be cited.

[0004] Patent document 1 describes an antibacterial and deodorizing hydrogel, which is a hydrogel containing fine powder of a calcium compound with calcium hydroxide as a main component, characterized in that, for the hydrogel, the dispersed substance constituting the gel is constructed into a three-dimensional network structure by physical cross-linking, and the fine powder of the calcium compound with calcium hydroxide as a main component is contained in the dispersion medium of the gel enclosed in the three-dimensional network structure, and the content of the fine powder of the calcium compound with calcium hydroxide as a main component is 5 to 300 parts by weight relative to 100 parts by weight of the hydrophilic polymer resin constituting the hydrogel.

[0005] Prior art literature

[0006] Patent Literature

[0007] Patent document 1: Japanese Patent Application Publication No. 2018-115140. Summary of the invention

[0008] Problems to be solved by the invention

[0009] In order to improve the balance between the dispersibility and retention of contained particles, a particle dispersion gel is required whose mesh size can be controlled according to the size of contained particles.

[0010] The present invention has been made in view of the above circumstances, and provides a particle dispersion gel whose mesh size can be easily controlled, a particle dispersion gel using the particle dispersion gel, a method for producing a particle dispersion gel whose mesh size can be easily controlled, and a method for producing a particle dispersion gel capable of improving the dispersibility of particles.

[0011] Means for solving problems

[0012] The present inventors have conducted intensive studies to achieve the above-mentioned objectives and have found that the mesh size can be easily controlled by including a polyol compound (B1) as the solvent (B) in a particle dispersion gel comprising a polymer (A) and a solvent (B), thereby completing the present invention.

[0013] According to the present invention, there are provided the following particle dispersion gel, particle dispersion gel, method for producing the particle dispersion gel, and method for producing the particle dispersion gel.

[0014] [1] A particle dispersion gel, comprising a polymer (A) and a solvent (B) and capable of dispersing particles therein, wherein the particle dispersion gel forms a three-dimensional network structure with the polymer (A), and the network structure contains the solvent (B), and the solvent (B) contains a polyol compound (B1).

[0015] [2] The particle dispersion gel according to the above [1], wherein the molecular weight of the polyol compound (B1) is 50 or more and 300 or less.

[0016] [3] The particle dispersion gel according to [1] or [2] above, wherein the viscosity of the solvent (B) measured at 25°C and 30 rpm using a Brookfield viscometer is 1 mPa·s or more and 200 mPa·s or less.

[0017] [4] The gel for particle dispersion according to any one of [1] to [3] above, wherein the boiling point of the solvent (B) is 180° C. or higher and 300° C. or lower.

[0018] [5] The particle dispersion gel according to any one of [1] to [4] above, wherein the polyol compound (B1) contains a diol compound (B2) having 2 to 6 carbon atoms.

[0019] [6] The particle dispersion gel according to any one of [1] to [5] above, wherein the polyol compound (B1) comprises one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol.

[0020] [7] The particle dispersion gel according to any one of [1] to [6], wherein the viscosity is measured using a cone-plate viscometer at 25°C, a cone angle of 2° / 20 mm, and a shear rate of 15 s -1 The viscosity of the particle dispersion gel measured under the conditions of is 10 mPa·s or more and 60000 mPa·s or less.

[0021] [8] A particle dispersion gel as described in any one of [1] to [7] above, wherein when the mode diameter of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is set to X1 (nm), and the median diameter of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is set to X2 (nm), X1 / X2 is greater than 0.20 and less than 2.0.

[0022] [9] The particle dispersion gel according to any one of [1] to [8] above, wherein the mode diameter X1 of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826:2019 is 10 nm or more.

[0023]

[10] The particle dispersion gel according to any one of [1] to [9] above, wherein the median diameter X2 of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826:2019 is 50 nm or more.

[0024]

[11] The particle dispersion gel as described in any one of [1] to

[10] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone.

[0025]

[12] The particle dispersion gel according to any one of [1] to

[11] above, wherein the content of the polymer (A) in the particle dispersion gel is 0.01% by mass or more and 20.0% by mass or less.

[0026]

[13] A particle-dispersed gel comprising the particle-dispersed gel according to any one of [1] to

[12] above and particles (C) dispersed in the particle-dispersed gel.

[0027]

[14] The particle dispersion gel as described in

[13] above, wherein the particles (C) contain one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents.

[0028]

[15] The particle dispersion gel according to

[13] or

[14] above, wherein the median particle size D of the particles (C) measured by laser diffraction scattering method is 50 It is not less than 0.01 μm and not more than 10 μm.

[0029]

[16] A method for producing a particle dispersion gel, which is used to produce the particle dispersion gel described in any one of [1] to

[12] above, wherein the production method comprises: a step of obtaining a gel-like substance by mixing the polymer (A) and the solvent (B); and a step of obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel-like substance.

[0030]

[17] The method for producing a gel for particle dispersion according to the above

[16] , wherein in the step of kneading the gel-like substance, the gel-like substance is kneaded using a roll mill.

[0031]

[18] A method for producing a particle-dispersed gel, which is a method for producing a particle-dispersed gel as described in any one of

[13] to

[15] above, wherein the method comprises: a step of obtaining a gel-like substance by mixing the polymer (A), the solvent (B) and the particles (C); and a step of obtaining a particle-dispersed gel having a three-dimensional network structure by kneading the gel-like substance.

[0032]

[19] The method for producing a particle dispersed gel as described in

[18] above, wherein the particle dispersed gel forms a three-dimensional network structure by the polymer (A), and the solvent (B) is contained in the network structure, and the particles (C) are contained in the network structure.

[0033]

[20] The method for producing a particle-dispersed gel according to

[18] or

[19] above, wherein in the step of kneading the gel-like substance, the gel-like substance is kneaded using a roll mill.

[0034]

[21] The method for producing a particle-dispersed gel according to any one of

[18] to

[20] above, wherein the content of the polymer (A) in the particle-dispersed gel is 0.01% by mass or more and 20.0% by mass or less.

[0035] Effects of the Invention

[0036] According to the present invention, there can be provided a particle dispersion gel whose mesh size can be easily controlled, a particle dispersion gel using the particle dispersion gel, a method for producing a particle dispersion gel whose mesh size can be easily controlled, and a method for producing a particle dispersion gel capable of improving the dispersibility of particles. DETAILED DESCRIPTION

[0037] Hereinafter, embodiments of the present invention will be described.

[0038] [Gel for particle dispersion]

[0039] The particle dispersion gel of the present embodiment is a particle dispersion gel that contains a polymer (A) and a solvent (B) and can disperse particles inside. The particle dispersion gel forms a three-dimensional network structure with the polymer (A), and the network structure contains a solvent (B), and the solvent (B) contains a polyol compound (B1).

[0040] As described above, in order to improve the balance between the dispersibility and retention of contained particles, a particle dispersion gel is required whose mesh size can be controlled according to the size of the contained particles.

[0041] The present inventors have conducted intensive research to achieve the above-mentioned problems. As a result, it has been found that in a particle dispersion gel comprising a polymer (A) and a solvent (B), by including a polyol compound (B1) as the solvent (B), the mesh size can be easily controlled. Specifically, the particle dispersion gel of the present embodiment can easily control the mesh size of the three-dimensional mesh structure of the particle dispersion gel by changing the concentration of the polymer (A) and the type of the polyol compound (B1).

[0042] Hereinafter, each component constituting the particle dispersion gel according to the present embodiment will be described in detail.

[0043] (Polymer (A))

[0044] The particle dispersion gel of the present embodiment contains a polymer (A). The polymer (A) forms a three-dimensional network structure in the particle dispersion gel of the present embodiment.

[0045] The polymer (A) is not particularly limited as long as it can be gelled and form a three-dimensional network structure by containing the solvent (B), and preferably contains one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers, and polyvinyl pyrrolidone, more preferably contains one or more selected from the group consisting of polysaccharides, (meth)acrylic acid polymers, polyvinyl alcohol polymers, and polyvinyl pyrrolidone, and further preferably contains one or more selected from the group consisting of polysaccharides, polyvinyl alcohol polymers, and polyvinyl pyrrolidone. Two or more, more preferably including polysaccharides, more preferably including water-soluble polysaccharides, more preferably including one or more water-soluble polysaccharides selected from the group consisting of Tremella polysaccharide, hyaluronic acid, xanthan gum, alginic acid, guar gum, cationized guar gum, carrageenan, gellan gum, agarose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose and cellulose nanofibers, more preferably including one or more water-soluble celluloses selected from the group consisting of carboxymethyl cellulose, hydroxypropyl cellulose and hydroxyethyl cellulose, more preferably including hydroxypropyl cellulose. Hydroxypropyl cellulose is a water-soluble cellulose derivative, usually, after cellulose is treated with an alkali such as sodium hydroxide, it is reacted with an etherifying agent such as propylene oxide to obtain. Hydroxypropyl cellulose can be purchased from Fujifilm and Kou Pure Chemical Industries, Ltd., for example.

[0046] From the viewpoint of further improving the mobility of the particles contained in the gel, the polymer (A) preferably contains 30% by mass or more of hydroxypropyl cellulose, more preferably 40% by mass or more, further preferably 50% by mass or more, further preferably 60% by mass or more, further preferably 80% by mass or more, and can preferably contain 100% by mass or less.

[0047] From the viewpoint of increasing the gel viscosity and further reducing the mesh size, the content of the polymer (A) in the particle dispersion gel of the present embodiment is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, further preferably 0.1% by mass or more, further preferably 0.2% by mass or more, further preferably 0.3% by mass or more, and from the viewpoint of further increasing the mesh size, it is preferably 20.0% by mass or less, more preferably 15.0% by mass or less, further preferably 10.0% by mass or less, further preferably 5.0% by mass or less, further preferably 2.5% by mass or less, further preferably 1.5% by mass or less, further preferably 1.0% by mass or less, further preferably 0.8% by mass or less.

[0048] (Solvent (B))

[0049] The particle dispersion gel of the present embodiment contains a polyol compound (B1) as a solvent (B).

[0050] The polyol compound (B1) is not particularly limited as long as it can be gelled together with the polymer (A) to form a three-dimensional network structure. From the viewpoint of further improving the controllability of the network size of the gel for particle dispersion, it preferably contains a diol compound (B2) having a carbon number of 2 to 6, more preferably contains one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol, and more preferably contains one or more selected from the group consisting of 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol.

[0051] The particle dispersion gel of the present embodiment may contain a solvent other than the polyol compound (B1) as the solvent (B).

[0052] The solvent other than the polyol compound (B1) is not particularly limited, and examples thereof include methanol, ethanol, isopropyl alcohol (IPA), N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N,N-dimethylacetamide, tetrahydrofuran (THF), acetone, methyl ethyl ketone (MEK), cyclohexanone, ethyl acetate, acetonitrile, dichloromethane, chloroform, toluene, acetic acid, 1-methoxy-2-propanol (PGME), water, etc., and any one of them can be used alone or in combination of two or more.

[0053] From the viewpoint of further improving the controllability of the mesh size of the gel for particle dispersion, the solvent (B) preferably contains 30% by mass or more of the polyol compound (B1), more preferably 40% by mass or more, further preferably 50% by mass or more, further preferably 60% by mass or more, further preferably 80% by mass or more, and can preferably contain 100% by mass or less.

[0054] From the viewpoint of further increasing the mesh size, further improving the gel strength, and further improving the mobility of the particles contained in the gel, the boiling point of the solvent (B) is preferably 180°C or higher, more preferably 190°C or higher, more preferably 195°C or higher, more preferably 200°C or higher, more preferably 210°C or higher, more preferably 220°C or higher, more preferably 230°C or higher, and more preferably 235°C or higher. From the viewpoint of further reducing the mesh size and further improving the dispersibility and retention of the particles contained in the gel, the boiling point is preferably 300°C or lower, more preferably 280°C or lower, more preferably 260°C or lower, more preferably 255°C or lower, and more preferably 245°C or lower.

[0055] From the viewpoint of further increasing the mesh size, further improving the gel strength, and further improving the mobility of the particles contained in the gel, the viscosity of the solvent (B) measured using a B-type viscometer at 25°C and a rotation speed of 30 rpm is preferably 1 mPa·s or more, more preferably 5 mPa·s or more, further preferably 10 mPa·s or more, further preferably 15 mPa·s or more, and further preferably 20 mPa·s or more. From the viewpoint of further reducing the mesh size and further improving the dispersibility and retention of the particles contained in the gel, it is preferably 200 mPa·s or less, more preferably 150 mPa·s or less, further preferably 100 mPa·s or less, and further preferably 80 mPa·s or less.

[0056] From the viewpoint of further increasing the mesh size, further improving the gel strength, and further improving the mobility of the particles contained in the gel, the molecular weight of the polyol compound (B1) is preferably 50 or more, more preferably 60 or more, further preferably 70 or more, further preferably 75 or more, further preferably 80 or more, and further preferably 85 or more. From the viewpoint of further reducing the mesh size and further improving the dispersibility and retention of the particles contained in the gel, it is preferably 300 or less, more preferably 250 or less, further preferably 200 or less, further preferably 150 or less, further preferably 130 or less, and further preferably 110 or less.

[0057] From the viewpoint of further improving the mobility of the particles contained in the gel and the viewpoint of further improving the stability of the gel, a cone-plate viscometer was used at 25°C, a cone angle of 2° / 20 mm, and a shear rate of 15 s. -1 The viscosity of the particle dispersion gel of the present embodiment measured under the conditions is preferably 10 mPa·s or more, more preferably 50 mPa·s or more, further preferably 100 mPa·s or more, further preferably 200 mPa·s or more, further preferably 300 mPa·s or more, further preferably 400 mPa·s or more, and is preferably 60000 mPa·s or less, more preferably 30000 mPa·s or less, further preferably 5000 mPa·s or less, further preferably 2000 mPa·s or less, further preferably 1500 mPa·s or less, further preferably 1000 mPa·s or less, further preferably 800 mPa·s or less.

[0058] When the mode diameter of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is set to X1 (nm), and the median diameter of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is set to (X2) (nm), X1 / X2 is preferably greater than or equal to 0.20 and less than or equal to 2.0.

[0059] It is required to improve the dispersibility of particles contained in the particle dispersion gel.

[0060] The inventors of the present invention have conducted intensive research to improve the dispersibility of particles contained in a particle dispersion gel. As a result, it was found that in a particle dispersion gel having a three-dimensional mesh structure, the dispersibility of the particles contained therein can be further improved by setting the ratio of the mode diameter and the median diameter of the three-dimensional mesh structure to a specific range. Specifically, the particle dispersion gel of the present embodiment can further improve the dispersibility of the particles contained therein by adjusting the X1 / X2 to a range of 0.20 or more and 2.0 or less.

[0061] In the particle dispersion gel of the present embodiment, from the viewpoint of further improving the dispersibility of the contained particles, the X1 / X2 is greater than 0.20, preferably greater than 0.30, more preferably greater than 0.40, further preferably greater than 0.50, further preferably greater than 0.60, and the X1 / X2 is less than 2.0, preferably less than 1.8, more preferably less than 1.7, further preferably less than 1.6.

[0062] From the viewpoint of further improving the mobility and dispersibility of the particles contained in the gel, the mode diameter (X1) of the three-dimensional network structure in the particle dispersion gel of the present embodiment measured by photon correlation spectroscopy in accordance with JISZ 8826:2019 is preferably 10 nm or more, more preferably 20 nm or more, further preferably 50 nm or more, further preferably 70 nm or more, further preferably 100 nm or more, further preferably 200 nm or more, further preferably 300 nm or more, further preferably 400 nm or more, and from the viewpoint of further improving the retention of the particles contained in the gel and the gel strength, it is preferably 10000 nm or less, more preferably 5000 nm or less, further preferably 2000 nm or less, further preferably 1500 nm or less, further preferably 1000 nm or less.

[0063] From the viewpoint of further improving the mobility and dispersibility of the particles contained in the gel, the median diameter (X2) of the three-dimensional network structure in the particle dispersion gel of the present embodiment measured by photon correlation spectroscopy in accordance with JISZ 8826:2019 is preferably 50 nm or more, more preferably 70 nm or more, further preferably 80 nm or more, further preferably 100 nm or more, further preferably 200 nm or more, further preferably 300 nm or more, further preferably 400 nm or more, further preferably 500 nm or more, and from the viewpoint of further improving the retention of the particles contained in the gel and the gel strength, it is preferably 10000 nm or less, more preferably 5000 nm or less, further preferably 2000 nm or less, further preferably 1500 nm or less, further preferably 1000 nm or less, further preferably 800 nm or less.

[0064] As the use of the particle dispersion gel of this embodiment, for example, it can be used for one or more gels selected from the group consisting of wiring repair materials, artificial tissue materials, regenerative stent materials, sealing materials, anti-adhesion materials, drug delivery materials, contact lens materials, sensor materials, surface coating materials, separation materials, antibacterial materials, deodorizing materials, wound covering materials, catalysts, antiviral agents and antifungal agents.

[0065] Among them, the particle dispersion gel of the present embodiment is preferably used as a gel constituting a wiring repair material.

[0066] The particles contained in the particle dispersion gel of this embodiment can be appropriately selected according to the purpose of the particle dispersion gel, and therefore, are not particularly limited. For example, one or more particles selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents, and antifungal agents can be mentioned.

[0067] Among them, the particles contained in the particle dispersion gel of this embodiment are preferably metal particles, more preferably conductive metal particles, and further preferably conductive metal particles containing one or more selected from the group consisting of copper, gold, silver and aluminum, and further preferably copper particles. In addition, the above-mentioned metal particles may also be composed of the above-mentioned metal only on their surfaces.

[0068] For example, when a disconnection occurs in an electrical wiring, the wiring repair material is a material for self-repairing wiring that can perform self-repair, and includes, for example, a particle dispersion gel and conductive metal particles. The conductive metal particles are dispersed in the particle dispersion gel. When a disconnection occurs in the wiring, the self-repairing wiring is repaired by the wiring repair material. When the disconnection is covered with the wiring repair material, a portion of the conductive metal particles short-circuits the disconnection, thereby energizing the disconnection.

[0069] [Method for producing gel for particle dispersion]

[0070] The particle dispersion gel of this embodiment can be obtained, for example, by the following production method, which includes: a step of obtaining a gel-like substance by mixing a polymer (A) and a solvent (B); and a step of obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel-like substance.

[0071] For example, from the viewpoint of improving the dispersibility of particles contained therein, a gel having a three-dimensional network structure is required to have improved uniformity of the network size.

[0072] The present inventors have conducted intensive research to achieve the above-mentioned problem. As a result, it was found that the uniformity of the mesh size of the gel can be improved by further kneading the gel-like substance obtained by mixing the polymer (A) and the solvent (B). Specifically, the uniformity of the mesh size of the gel can be improved by kneading the gel-like substance obtained by mixing the polymer (A) and the solvent (B).

[0073] (Step of Obtaining a Gel-like Material)

[0074] In the particle dispersion gel of the present embodiment, in the step of obtaining a gel, the polymer (A) and the solvent (B) are mixed to obtain a gel. For example, the gel can be obtained by the following steps.

[0075] First, a polymer (A) and a solvent (B) are mixed. As polymer (A) and solvent (B), the aforementioned substances can be used. Then, the obtained mixture is heated to about 40 to 100° C. while being stirred. There is no particular limitation on the heating time as long as the mixture is appropriately gelled, and it is, for example, about 1 to 60 minutes. It should be noted that even without heating (room temperature), the mixture will gel as long as sufficient time has passed. Then, heating and stirring are stopped, and the mixture is allowed to stand, so that a gel-like substance can be obtained.

[0076] (Step of Obtaining Particle Dispersion Gel)

[0077] Then, the gel-like substance is kneaded to obtain a particle dispersion gel having a three-dimensional network structure.

[0078] As a mixing method for the gel-like material, from the viewpoint of further improving the uniformity of the three-dimensional network structure in the particle dispersion gel of this embodiment, it is preferred to use at least one mixing selected from the group consisting of a roller mill and a ball mill, and more preferably to use mixing using a roller mill.

[0079] The roll mill of this embodiment preferably has three or more rolls, and more preferably is a triple roll mill. This allows continuous kneading of the gel-like material, and thus can further improve the productivity of the obtained particle dispersion gel.

[0080] [Particle dispersion gel]

[0081] The particle-dispersed gel of the present embodiment includes the particle-dispersed gel of the present embodiment and particles (C) dispersed in the particle-dispersed gel.

[0082] From the viewpoint of increasing the gel viscosity and further reducing the mesh size, the content of the polymer (A) in the particle dispersion gel of the present embodiment is preferably 0.01 mass % or more, more preferably 0.05 mass % or more, further preferably 0.1 mass % or more, further preferably 0.2 mass % or more, further preferably 0.3 mass % or more, and from the viewpoint of further increasing the mesh size, it is preferably 20.0 mass % or less, more preferably 15.0 mass % or less, further preferably 10.0 mass % or less, further preferably 5.0 mass % or less, further preferably 2.5 mass % or less, further preferably 1.5 mass % or less, further preferably 1.0 mass % or less, further preferably 0.8 mass % or less.

[0083] The content of the particles (C) in the particle dispersion gel of the present embodiment can be appropriately selected according to the purpose of the particle dispersion gel and the type of particles (C) contained, and is therefore not particularly limited. When the entire particle dispersion gel is set to 100 mass%, it is, for example, 0.01 mass% or more, preferably 0.02 mass% or more, more preferably 0.05 mass% or more, and further preferably 0.3 mass% or more, and, for example, 30 mass% or less, preferably 10 mass% or less, more preferably 5 mass% or less, further preferably 1 mass% or less, and further preferably 0.5 mass% or less.

[0084] As uses of the particle dispersion gel of this embodiment, for example, one or more selected from the group consisting of wiring repair materials, materials for artificial tissues, materials for regenerative stents, sealing materials, anti-adhesion materials, materials for drug delivery, materials for contact lenses, sensor materials, surface coating materials, separation materials, antibacterial materials, deodorizing materials, wound covering materials, catalysts, antiviral agents, and antifungal agents can be cited.

[0085] Among them, the particle dispersion gel of the present embodiment is preferably used as a wiring repair material.

[0086] The particles (C) used in the particle dispersion gel of the present embodiment can be appropriately selected according to the purpose of the particle dispersion gel and are therefore not particularly limited. For example, one or more particles selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents, and antifungal agents can be cited.

[0087] Among them, the particles (C) used in the particle dispersion gel of this embodiment are preferably metal particles, more preferably conductive metal particles, and more preferably conductive metal particles containing one or more selected from the group consisting of copper, gold, silver and aluminum, and more preferably copper particles. In addition, the above-mentioned metal particles may also be composed of the above-mentioned metal only on their surface.

[0088] From the viewpoint of further improving the mobility and dispersibility of the particles (C), the median particle size D of the particles (C) measured by laser diffraction scattering method is 50 It is preferably 0.01 μm or more, more preferably 0.05 μm or more, further preferably 0.1 μm or more, further preferably 0.3 μm or more, and from the viewpoint of further improving the retention of particles (C), it is preferably 10 μm or less, more preferably 5 μm or less, further preferably 3 μm or less, further preferably 1 μm or less.

[0089] [Method for producing particle dispersion gel]

[0090] The particle-dispersed gel of the present embodiment can be obtained, for example, by kneading the particle-dispersed gel of the present embodiment and the particles (C).

[0091] As a method for kneading the particle dispersion gel of the present embodiment and the particles (C), from the viewpoint of further improving the dispersibility of the particles (C) in the particle dispersion gel of the present embodiment, it is preferred to use at least one kneading selected from the group consisting of a roller mill and a ball mill, and more preferably to use kneading using a roller mill.

[0092] The roll mill of this embodiment preferably comprises three or more rolls, and more preferably a triple roll mill. Thus, the particle dispersion gel of this embodiment and the particles can be continuously kneaded, thereby further improving the productivity of the obtained particle dispersion gel.

[0093] In addition, the particle-dispersed gel of the present embodiment can also be obtained, for example, by the following manufacturing method, which includes: a process of obtaining a gel-like substance by mixing a polymer (A), a solvent (B) and particles (C); and a process of obtaining a particle-dispersed gel having a three-dimensional network structure by kneading the gel-like substance.

[0094] According to the method for producing a particle-dispersed gel of the present embodiment, the dispersibility of the particles (C) can be improved by further kneading the gel-like substance obtained by mixing the polymer (A), the solvent (B) and the particles (C). Specifically, the uniformity of the mesh size of the gel can be improved by further kneading the gel-like substance obtained by mixing the polymer (A), the solvent (B) and the particles (C).

[0095] The particle dispersed gel obtained by the method for producing a particle dispersed gel according to the present embodiment has, for example, a three-dimensional network structure formed by the polymer (A), and the network structure contains the solvent (B), and the particles (C) are contained in the network structure.

[0096] (Step of Obtaining a Gel-like Material)

[0097] In the method for producing a particle-dispersed gel of the present embodiment, in the step of obtaining a gel, the polymer (A), the solvent (B) and the particles (C) are mixed to obtain a gel. For example, the gel can be obtained by the following steps.

[0098] First, a polymer (A), a solvent (B) and particles (C) are mixed. As polymer (A) and solvent (B), the aforementioned substances can be used. Then, the obtained mixture is heated to about 40 to 100°C while being stirred. There is no particular limitation on the heating time as long as the mixture is moderately gelled, and it is, for example, about 1 to 60 minutes. It should be noted that even without heating (room temperature), the mixture will gel as long as sufficient time has passed. Then, heating and stirring are stopped, and the mixture is allowed to stand, so that a gel-like substance can be obtained.

[0099] (Step of Obtaining Particle Dispersed Gel)

[0100] Then, the gel-like substance is kneaded to obtain a particle-dispersed gel having a three-dimensional network structure.

[0101] As a kneading method for the gel-like material, from the viewpoint of further improving the uniformity of the three-dimensional mesh size in the particle dispersed gel of this embodiment, it is preferred to use at least one kneading selected from the group consisting of a roller mill and a ball mill, and more preferably to use kneading using a roller mill.

[0102] The roll mill of this embodiment is preferably composed of three or more rolls, and more preferably a triple roll mill. This allows continuous kneading of the gel-like material, thereby further improving the productivity of the obtained particle-dispersed gel.

[0103] As mentioned above, although embodiment of this invention was demonstrated, these are examples of this invention, Various structures other than the above-mentioned can be adopted within the range which does not impair the effect of this invention.

[0104] It should be noted that the present invention is not limited to the above-described embodiments, and modifications, improvements, etc. within the scope that can achieve the object of the present invention are also included in the present invention.

[0105] Example

[0106] Hereinafter, the present invention will be described in detail with reference to Examples, but the present invention is not limited to the description of these Examples.

[0107] [Material]

[0108] The details of the materials used in the production of the particle dispersion gel are as follows.

[0109] (Polymer (A))

[0110] Hydroxypropyl cellulose (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0111] (Solvent (B))

[0112] Ethylene glycol (molecular weight: 62.07, boiling point: 198° C., manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0113] 1,3-Propanediol (molecular weight: 76.09, boiling point: 214°C, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0114] 1,4-Butanediol (molecular weight: 90.12, boiling point: 230° C., manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0115] 1,5-Pentanediol (molecular weight: 104.15, boiling point: 242°C, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0116] 1,6-Hexanediol (molecular weight: 118.17, boiling point: 250° C., manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.).

[0117] (Particles(C))

[0118] Copper particles: (metal copper powder manufactured by FURUKAWA CHEMICALS CO., LTD., product number: FMC-SB, median particle size D measured by laser diffraction scattering method) 50 :0.7μm).

[0119] [Measurement and evaluation]

[0120] In the present examples, various measurements and evaluations were performed by the following methods.

[0121] (Viscosity of solvent (B))

[0122] The viscosity of the solvent (B) was measured using a B-type viscometer (manufactured by Toki Sangyo Co., Ltd., product name: TVB-10M, rotor number 1) at 25°C, a rotation speed of 30 rpm, and 200 mL of the solvent (B). Here, when two or more mixed solvents are used as the solvent (B), the viscosity of the mixed solvent is measured.

[0123] (Viscosity of the particle dispersion gel)

[0124] A cone-plate viscometer (manufactured by Spectris Co., LTD., UK, product name: Kinexuspro+) was used at 25°C, cone angle 2° / 20 mm, shear rate 15 s -1 The viscosity of the gel was measured under the conditions of .

[0125] (Mode diameter (X1), median diameter (X2) and half-value width of three-dimensional network structure of particle dispersion gel)

[0126] The mode diameter (X1), median diameter (X2) and half-value width of the three-dimensional mesh structure of the particle dispersion gel are measured by photon correlation spectroscopy according to JIS Z 8826:2019. As a measuring device, a nanoparticle analyzer SZ-100V2 gel unit manufactured by HORIBA, Japan, was used. As measurement conditions, the detection range was set to 0.3nm~10μm, the distribution form was set to polydisperse width, and the laser irradiation position was set to 10 points (0~900μm) with a step length of 100μm. In the case where bubbles were mixed in when the sample was put into the measuring cell, a degassing treatment was performed.

[0127] The half-value width of the mesh size distribution curve of the obtained three-dimensional mesh structure was calculated. The half-value width was calculated by calculating two points of mesh size (nm) where the frequency (%) of the mesh size distribution curve was half of the maximum value, and the difference between them was taken as the half-value width.

[0128] (Evaluation of particle dispersibility)

[0129] 50 g of the gel for particle dispersion obtained in Examples 11 to 16 and 20 mg of copper particles as particles (C) were fully mixed to obtain a mixture.

[0130] Then, 50 g of the obtained mixture was passed through a three-roll mill (BR-150V manufactured by IMEX Co., Ltd.) once to obtain a copper particle dispersion gel. Here, the number of passes through the first to third rollers of the three-roll mill was set to once. Each roller used a roller with a diameter of 63.5 mm, and the distance between the rollers was 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller = 1.0:2.4:6.0, and the rotation speed of the third roller was set to 80 rpm. The following dispersibility evaluation was performed on the obtained copper particle dispersion gel.

[0131] First, 50 g of the obtained copper particle dispersion gel was left to stand for 24 hours, and the dispersibility of the copper particles was evaluated by visual inspection according to the following criteria.

[0132] A (good dispersibility): The copper particles are uniformly dispersed in the gel, and the dispersibility of the copper particles is good (the entire gel is reddish brown).

[0133] B (poor dispersibility): The copper particles are unevenly distributed in the gel, and the dispersibility of the copper particles is poor (the gel is reddish brown as a whole, but the color tone varies).

[0134] (Evaluation of Dispersibility of Copper Particles)

[0135] 50 g of the copper particle dispersion gel obtained in Examples 19 and 20 was left to stand for 24 hours, and the dispersibility of the copper particles was evaluated by visual observation.

[0136] Example 1

[0137] First, hydroxypropyl cellulose as a polymer (A) and ethylene glycol as a solvent (B) were fully mixed to obtain a mixture. The amounts of the polymer (A) and the solvent (B) were as shown in Table 1. The obtained mixture was heated at 50° C. for 2 minutes while being stirred. Thus, the mixture became a gel.

[0138] After stopping the heating, the obtained gel was allowed to stand to room temperature (23°C). Then, 100 g of the gel that reached room temperature was passed through a three-roll mill (BR-150V manufactured by IMEX Co., Ltd.) 4 times to obtain a gel for particle dispersion. Here, the number of passes through the first to third rollers of the three-roll mill was set to once. Each roller used a roller with a diameter of 63.5 mm, and the distance between the rollers was set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller = 1.0:2.4:6.0, and the rotation speed of the third roller was set to 80 rpm. The above-mentioned measurements were performed on the obtained gel for particle dispersion. The results are shown in Table 1.

[0139] Embodiments 2 to 10

[0140] The same procedure as in Example 1 was carried out except that the mixture of the polymer (A) and the solvent (B) was changed to the mixture shown in Table 1, thereby obtaining a particle dispersion gel. The above-mentioned measurements were performed on the obtained particle dispersion gel. The results are shown in Table 1.

[0141] Table 1

[0142]

[0143] It can be understood from Table 1 that the mesh size of the particle dispersion gel can be changed by changing the type of the polyol compound (B1) and the concentration of the polymer (A). In other words, it can be seen that the particle dispersion gel of the present embodiment can easily control the mesh size.

[0144] Embodiment 11

[0145] First, hydroxypropyl cellulose as a polymer (A) and ethylene glycol as a solvent (B) were fully mixed to obtain a mixture. The amounts of the polymer (A) and the solvent (B) were as shown in Table 2. The obtained mixture was heated at 50° C. for 2 minutes while being stirred. Thus, the mixture became a gel.

[0146] After stopping the heating, the obtained gel was allowed to stand to room temperature (23°C). Then, 100 g of the gel that reached room temperature was passed through a three-roll mill (BR-150V manufactured by IMEX Co., Ltd.) 4 times to obtain a gel for particle dispersion. Here, the number of passes through the first to third rollers of the three-roll mill was set to once. Each roller used a roller with a diameter of 63.5 mm, and the distance between the rollers was set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller = 1.0:2.4:6.0, and the rotation speed of the third roller was set to 80 rpm. The above-mentioned measurements were performed on the obtained gel for particle dispersion. The results are shown in Table 2.

[0147] Embodiments 12 to 16

[0148] The same procedure as in Example 11 was carried out except that the mixture of the polymer (A) and the solvent (B) was changed to the mixture shown in Table 2, thereby obtaining the particle dispersion gels. The above-mentioned measurements were performed on the obtained particle dispersion gels. The results are shown in Table 2.

[0149] Table 2

[0150]

[0151] It can be understood from Table 2 that the dispersibility of the particles contained in the particle dispersion gels of Examples 12 to 16 in which X1 / X2 is 0.20 or more and 2.0 or less is improved compared to the particle dispersion gel of Example 11 in which X1 / X2 is less than 0.20. In other words, it can be seen that the particle dispersion gel in which X1 / X2 is 0.20 or more and 2.0 or less can improve the dispersibility of the particles contained therein.

[0152] Embodiment 17

[0153] First, hydroxypropyl cellulose as a polymer (A) and 1,3-propylene glycol as a solvent (B) were fully mixed to obtain a mixture. The amounts of the polymer (A) and the solvent (B) were as shown in Table 3. The obtained mixture was heated at 50° C. for 2 minutes while being stirred. Thus, the mixture became a gel.

[0154] After stopping the heating, the obtained gel was allowed to stand to room temperature (23°C). Then, 100 g of the gel that reached room temperature was passed through a three-roll mill (BR-150V manufactured by IMEX Co., Ltd.) 4 times to obtain a gel. Here, the number of passes through the first to third rollers of the three-roll mill was set to once. Each roller used a roller with a diameter of 63.5 mm, and the distance between the rollers was set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller = 1.0:2.4:6.0, and the rotation speed of the third roller was set to 80 rpm. The above measurements were performed on the obtained gels. The results are shown in Table 3.

[0155] Embodiment 18

[0156] First, hydroxypropyl cellulose as a polymer (A) and 1,3-propylene glycol as a solvent (B) were fully mixed to obtain a mixture. The amounts of the polymer (A) and the solvent (B) were as shown in Table 3. The obtained mixture was heated at 50° C. for 2 minutes while being stirred. Thus, the mixture became a gel.

[0157] After stopping the heating, the obtained gel was left to stand at room temperature (23° C.) to obtain a gel. The above-mentioned measurements were performed on the obtained gels. The results are shown in Table 3.

[0158] [Table 3]

[0159]

[0160] It can be understood from Table 3 that the half width of the mesh size distribution curve of the gel obtained by the production method of Example 17 is small, and the uniformity of the mesh size of the gel is improved compared with the gel obtained by the production method of Example 18. In other words, it can be seen that the uniformity of the mesh size of the obtained gel can be improved by kneading the gel-like material obtained by mixing the polymer (A) and the solvent (B).

[0161] Embodiment 19

[0162] First, 0.5 g of hydroxypropylcellulose as a polymer (A), 50 g of ethylene glycol as a solvent (B), and 20 mg of copper particles as particles (C) were fully mixed to obtain a mixture, and the obtained mixture was heated at 50° C. for 2 minutes while being stirred, thereby forming a gel.

[0163] After stopping the heating, the obtained gel was allowed to stand to room temperature (23°C). Then, 50 g of the gel that reached room temperature was passed through a three-roll mill (BR-150V manufactured by IMEX Co., Ltd.) 4 times to obtain a copper particle dispersed gel. Here, the number of passes through the first to third rollers of the three-roll mill was set to once. Each roller used a roller with a diameter of 63.5 mm, and the distance between the rollers was set to 10 μm. In addition, the rotation speed of the first roller: the rotation speed of the second roller: the rotation speed of the third roller = 1.0:2.4:6.0, and the rotation speed of the third roller was set to 80 rpm. The dispersibility of the copper particles in the obtained copper particle dispersed gel was evaluated. As a result, the copper particles were uniformly dispersed in the gel, and the dispersibility of the copper particles was good (the gel was reddish brown as a whole).

[0164] Embodiment 20

[0165] First, 0.5 g of hydroxypropylcellulose as a polymer (A), 50 g of ethylene glycol as a solvent (B), and 20 mg of copper particles as particles (C) were fully mixed to obtain a mixture, and the obtained mixture was heated at 50° C. for 2 minutes while being stirred, thereby forming a gel.

[0166] After stopping the heating, the obtained gel was left to stand at room temperature (23°C) to obtain a copper particle dispersed gel. The copper particle dispersion gel obtained was evaluated for the dispersibility of the copper particles. As a result, the copper particles were unevenly distributed in the gel, and the dispersibility of the copper particles was poor (the gel was reddish brown as a whole, but the color tone was shady).

[0167] This application is based on Japanese patent applications No. 2022-126110, No. 2022-126111, and No. 2022-126112 filed on August 8, 2022, and claims the priority of these Japanese patent applications, the entire contents of which are incorporated herein by reference in this application.

[0168] The present invention can also be implemented in the following manners.

[0169] [1a] A particle dispersion gel, comprising a polymer (A) and a solvent (B) and capable of dispersing particles therein, wherein the particle dispersion gel forms a three-dimensional network structure with the polymer (A), and the network structure contains the solvent (B), and the solvent (B) contains a polyol compound (B1).

[0170] [2a] The particle dispersion gel according to the above [1a], wherein the molecular weight of the polyol compound (B1) is 50 or more and 300 or less.

[0171] [3a] The particle dispersion gel according to [1a] or [2a] above, wherein the viscosity of the solvent (B) measured at 25°C and 30 rpm using a Brookfield viscometer is 1 mPa·s or more and 200 mPa·s or less.

[0172] [4a] The gel for particle dispersion according to any one of [1a] to [3a] above, wherein the boiling point of the solvent (B) is 180° C. or higher and 300° C. or lower.

[0173] [5a] The particle dispersion gel according to any one of [1a] to [4a] above, wherein the polyol compound (B1) contains a diol compound (B2) having 2 to 6 carbon atoms.

[0174] [6a] The particle dispersion gel as described in any one of [1a] to [5a] above, wherein the polyol compound (B1) contains one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol.

[0175] [7a] The particle dispersion gel according to any one of [1a] to [6a], wherein the viscosity is measured using a cone-plate viscometer at 25°C, a cone angle of 2° / 20 mm, and a shear rate of 15 s -1 The viscosity of the particle dispersion gel measured under the conditions of is 10 mPa·s or more and 60000 mPa·s or less.

[0176] [8a] The particle dispersion gel according to any one of [1a] to [7a] above, wherein the mode diameter (X1) of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826 is 10 nm or more.

[0177] [9a] The particle dispersion gel according to any one of [1a] to [8a] above, wherein the median diameter (X2) of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826 is 50 nm or more.

[0178] [10a] The particle dispersion gel as described in any one of [1a] to [9a] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone.

[0179] [11a] The particle dispersion gel according to any one of [1a] to [10a] above, wherein the content of the polymer (A) in the particle dispersion gel is 0.01% by mass or more and 20.0% by mass or less.

[0180] [12a] A particle-dispersed gel comprising the particle-dispersed gel according to any one of [1a] to [11a] above and particles dispersed in the particle-dispersed gel.

[0181] [13a] The particle dispersion gel as described in [12a] above, wherein the particles contain one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents.

[0182] [14a] The particle dispersion gel according to [12a] or [13a] above, wherein the median particle size D of the particles measured by laser diffraction scattering method is 50 It is not less than 0.01 μm and not more than 10 μm.

[0183] [15a] A method for producing a particle dispersion gel, which is a method for producing a particle dispersion gel as described in any one of [1a] to [11a] above, wherein the method comprises: a step of obtaining a gel-like substance by mixing the polymer (A) and the solvent (B); and a step of obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel-like substance.

[0184] The present invention can also be implemented in the following manners.

[0185] [1b] A particle dispersion gel, comprising a polymer (A) and a solvent (B) and capable of dispersing particles therein, wherein the particle dispersion gel forms a three-dimensional network structure with the polymer (A), and the network structure contains the solvent (B), and when the mode diameter of the three-dimensional network structure measured by the photon correlation spectroscopy method in accordance with JIS Z 8826 is set to X1 (nm), and the median diameter of the three-dimensional network structure measured by the photon correlation spectroscopy method in accordance with JIS Z 8826 is set to (X2) (nm), X1 / X2 is greater than 0.20 and less than 2.0.

[0186] [2b] The gel for particle dispersion according to the above [1b], wherein the solvent (B) contains a polyol compound (B1).

[0187] [3b] The particle dispersion gel according to the above [2b], wherein the polyol compound (B1) contains a diol compound (B2) having 2 to 6 carbon atoms.

[0188] [4b] The particle dispersion gel as described in [2b] or [3b] above, wherein the polyol compound (B1) contains one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol.

[0189] [5b] The particle dispersion gel according to any one of [1b] to [4b] above, wherein the mode diameter (X1) of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826 is 10 nm or more.

[0190] [6b] The particle dispersion gel as described in any one of [1b] to [5b] above, wherein the median diameter (X2) of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826 is 50 nm or more.

[0191] [7b] The particle dispersion gel as described in any one of [1b] to [6b] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone.

[0192] [8b] The particle dispersion gel according to any one of [1b] to [7b], wherein the content of the polymer (A) in the particle dispersion gel is 0.01% by mass or more and 20.0% by mass or less.

[0193] [9b] A particle-dispersed gel comprising the particle-dispersing gel according to any one of [1b] to [8b] above and particles dispersed in the particle-dispersing gel.

[0194] [10b] The particle dispersion gel as described in [9b] ​​above, wherein the particles contain one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents.

[0195] [11b] The particle dispersion gel according to [9b] ​​or [10b] above, wherein the median particle size D of the particles measured by laser diffraction scattering method is 50 It is not less than 0.01 μm and not more than 10 μm.

[0196] [12b] A method for producing a gel for particle dispersion, which is a method for producing a gel for particle dispersion as described in any one of [1b] to [8b] above, wherein the method comprises: a step of obtaining a gel-like substance by mixing the polymer (A) and the solvent (B); and a step of obtaining a gel for particle dispersion having a three-dimensional network structure by kneading the gel-like substance.

[0197] The present invention can also be implemented in the following manners.

[0198] [1c] A method for producing a gel, which is a method for producing a gel comprising a polymer (A) and a solvent (B) and having a three-dimensional network structure, wherein the method comprises: a step of obtaining a gel-like substance by mixing the polymer (A) and the solvent (B); and a step of obtaining a gel-like substance by kneading the gel-like substance.

[0199] [2c] The method for producing a gel according to the above [1c], wherein the gel forms a three-dimensional network structure by the polymer (A), and the solvent (B) is contained in the network structure.

[0200] [3c] The method for producing a gel according to [1c] or [2c] above, wherein in the step of kneading the gel-like substance, the gel-like substance is kneaded using a roll mill.

[0201] [4c] The method for producing a gel according to any one of [1c] to [3c] above, wherein the solvent (B) contains a polyol compound (B1).

[0202] [5c] The method for producing a gel according to the above [4c], wherein the polyol compound (B1) contains a diol compound (B2) having 2 to 6 carbon atoms.

[0203] [6c] The method for producing a gel as described in [4c] or [5c] above, wherein the polyol compound (B1) contains one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol.

[0204] [7c] The method for producing a gel as described in any one of [1c] to [6c] above, wherein the mode diameter (X1) of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826 is 10 nm or more.

[0205] [8c] The method for producing a gel as described in any one of [1c] to [7c] above, wherein the median diameter (X2) of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z8826 is 50 nm or more.

[0206] [9c] A method for producing a gel as described in any one of [1c] to [8c] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone.

[0207] [10c] The method for producing a gel according to any one of [1c] to [9c] above, wherein the content of the polymer (A) in the gel is 0.01% by mass or more and 20.0% by mass or less.

[0208] [11c] A method for producing a particle-dispersed gel, which is a method for producing a particle-dispersed gel comprising a polymer (A), a solvent (B) and particles (C) and having a three-dimensional network structure, wherein the method comprises: a step of obtaining a gel-like substance by mixing the polymer (A), the solvent (B) and the particles (C); and a step of obtaining a particle-dispersed gel having a three-dimensional network structure by kneading the gel-like substance.

[0209] [12c] A method for producing a particle dispersed gel as described in [11c] above, wherein the particle dispersed gel forms a three-dimensional network structure through the polymer (A), and the solvent (B) is contained in the network structure, and the particles (C) are contained in the network structure.

[0210] [13c] The method for producing a particle-dispersed gel as described in [11c] or [12c] above, wherein in the step of kneading the gel-like substance, the gel-like substance is kneaded using a roll mill.

[0211] [14c] The method for producing a particle-dispersed gel according to any one of [11c] to [13c] above, wherein the solvent (B) contains a polyol compound (B1).

[0212] [15c] The method for producing a particle dispersion gel according to the above [14c], wherein the polyol compound (B1) contains a diol compound (B2) having 2 to 6 carbon atoms.

[0213] [16c] A method for producing a particle dispersed gel as described in [14c] or [15c] above, wherein the polyol compound (B1) comprises one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol and 1,6-hexanediol.

[0214] [17c] A method for producing a particle dispersed gel as described in any one of [11c] to [16c] above, wherein the polymer (A) comprises one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers and polyvinyl pyrrolidone.

[0215] [18c] The method for producing a particle-dispersed gel according to any one of [11c] to [17c] above, wherein the content of the polymer (A) in the particle-dispersed gel is 0.01% by mass or more and 20.0% by mass or less.

[0216] [19c] A method for producing a particle dispersed gel as described in any one of [11c] to [18c] above, wherein the particles (C) contain one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents and antifungal agents.

[0217] [20c] The method for producing a particle-dispersed gel according to any one of [11c] to [19c] above, wherein the median particle size D of the particles (C) measured by a laser diffraction scattering method is 50 It is not less than 0.01 μm and not more than 10 μm.

Claims

1. A particle dispersing gel, comprising a polymer (A) and a solvent (B) and capable of dispersing particles therein, wherein: The particle dispersion gel forms a three-dimensional network structure with the polymer (A), and contains the solvent (B) in the network structure. The solvent (B) contains a polyol compound (B1).

2. The particle dispersion gel according to claim 1, wherein The molecular weight of the polyol compound (B1) is 50 or more and 300 or less.

3. The particle dispersion gel according to claim 1 or 2, wherein The viscosity of the solvent (B) measured at 25° C. and a rotation speed of 30 rpm using a Brookfield viscometer is 1 mPa·s or more and 200 mPa·s or less.

4. The particle dispersion gel according to any one of claims 1 to 3, wherein The boiling point of the solvent (B) is 180° C. or higher and 300° C. or lower.

5. The particle dispersion gel according to any one of claims 1 to 4, wherein The polyol compound (B1) contains a diol compound (B2) having 2 to 6 carbon atoms.

6. The particle dispersion gel according to any one of claims 1 to 5, wherein The polyol compound (B1) includes one or more selected from the group consisting of ethylene glycol, 1,3-propylene glycol, 1,4-butanediol, 1,5-pentanediol, and 1,6-hexanediol.

7. The particle dispersion gel according to any one of claims 1 to 6, wherein The viscometer was used at 25°C, cone angle 2° / 20mm, shear rate 15s. -1 The viscosity of the particle dispersion gel measured under the conditions of is 10 mPa·s or more and 60000 mPa·s or less.

8. The particle dispersion gel according to any one of claims 1 to 7, wherein When the mode diameter of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is X1 (nm), and the median diameter of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is X2 (nm), X1 / X2 is greater than or equal to 0.20 and less than or equal to 2.

0.

9. The particle dispersion gel according to any one of claims 1 to 8, wherein The mode diameter X1 of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is 10 nm or more.

10. The particle dispersion gel according to any one of claims 1 to 9, wherein The median diameter X2 of the three-dimensional network structure measured by photon correlation spectroscopy in accordance with JIS Z 8826:2019 is 50 nm or more.

11. The particle dispersion gel according to any one of claims 1 to 10, wherein The polymer (A) includes one or more selected from the group consisting of polysaccharides, proteins, peptides, (meth)acrylic acid polymers, polyvinyl alcohol polymers, and polyvinyl pyrrolidone.

12. The particle dispersion gel according to any one of claims 1 to 11, wherein The content of the polymer (A) in the particle dispersion gel is 0.01 mass % or more and 20.0 mass % or less.

13. A particle dispersion gel, wherein: The particle dispersion gel comprises the particle dispersion gel according to any one of claims 1 to 12 and particles (C) dispersed in the particle dispersion gel.

14. The particle dispersion gel according to claim 13, wherein The particles (C) include one or more selected from the group consisting of drugs, fragrances, antibacterial agents, fungicides, cells, metal particles, inorganic particles, polymer particles, catalysts, antiviral agents, and antifungal agents.

15. The particle dispersion gel according to claim 13 or 14, wherein The median particle size D of the particles (C) measured by laser diffraction scattering method is 50 It is not less than 0.01 μm and not more than 10 μm.

16. A method for producing a particle dispersion gel, the method being for producing the particle dispersion gel according to any one of claims 1 to 12, wherein: The manufacturing method comprises: A step of obtaining a gel by mixing the polymer (A) and the solvent (B); and A step of obtaining a particle dispersion gel having a three-dimensional network structure by kneading the gel-like substance.

17. The method for producing a gel for particle dispersion according to claim 16, wherein: In the step of kneading the gel-like substance, the gel-like substance is kneaded using a roll mill.

18. A method for producing a particle-dispersed gel, the method being for producing the particle-dispersed gel according to any one of claims 13 to 15, wherein: The manufacturing method comprises: a step of obtaining a gel by mixing the polymer (A), the solvent (B) and the particles (C); and A step of obtaining a particle-dispersed gel having a three-dimensional network structure by kneading the gel-like substance.

19. The method for producing a particle-dispersed gel according to claim 18, wherein: The particle dispersion gel forms a three-dimensional network structure through the polymer (A), and the network structure contains the solvent (B). The particles (C) are contained in the network structure.

20. The method for producing a particle-dispersed gel according to claim 18 or 19, wherein: In the step of kneading the gel-like substance, the gel-like substance is kneaded using a roll mill.

21. The method for producing a particle-dispersed gel according to any one of claims 18 to 20, wherein: The content of the polymer (A) in the particle-dispersed gel is 0.01% by mass or more and 20.0% by mass or less.

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