Extraction process of rhizome traditional Chinese medicinal materials

Abstract

Aiming at the problem that the cell walls of the rhizome traditional Chinese medicinal materials are tough, the rhizome traditional Chinese medicinal materials are moistened by saturated steam after being subjected to negative pressure treatment, so that the medicinal materials become soft and easy to cut, the cell wall permeability of the rhizome traditional Chinese medicinal materials is improved, and the processing full degree is improved; a 20-40% ethanol water solution is adopted for full infiltration and pressurization to 5-8 atm, and then rapid pressure relief is conducted, so that the cell structure is fully destroyed, and the leaching rate of medicinal components is increased. In order to solve the problem that heavy metals are easy to accumulate in the planting process of traditional Chinese medicinal materials, a roughly filtered extracting solution is adsorbed by using chelating macroporous resin, so that the traditional Chinese medicinal extract does not contain or only contains extremely low heavy metals. According to the method, microfiltration, ultrafiltration and macroporous resin adsorption are sequentially used, so that the content of impurities such as pigment, tannin and protein in the traditional Chinese medicine extract powder is reduced, and the quality grade and safety of the traditional Chinese medicine extract are ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine extraction, and more specifically, to an extraction process of rhizome Chinese medicinal materials. Background Art

[0002] The extraction process of rhizomes of Chinese medicinal materials has certain difficulties, including: Hard cell wall: Since the cell wall of rhizomes is relatively tough, it increases the difficulty of solvent penetration into the cell, thus affecting the extraction efficiency. Difficulty in removing impurities: The extract is often accompanied by impurities such as pigments, tannins, proteins, starch, etc. The presence of these impurities will not only affect the purity of the final product, but may also interfere with subsequent analysis and testing. How to effectively remove these impurities without losing the active ingredients is a challenge. Heavy metal and pesticide residue problems: Heavy metals and pesticide residues may be introduced during the cultivation of Chinese medicine, especially when the rhizomes are in the soil. After the soil is polluted, the heavy metal content in the rhizomes may be high. If these harmful substances cannot be effectively removed, it will directly affect the safety and quality of Chinese medicine. Therefore, when designing the extraction process, it is also necessary to consider how to minimize the risk of these pollutants. Summary of the invention

[0003] 1. Technical issues to be resolved

[0004] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides an extraction process for rhizomes of Chinese medicinal materials, which can further improve the extraction rate of drugs in rhizomes of medicinal materials, reduce the impurity content and heavy metal residues of the extracted drugs, thereby ensuring the quality and safety of the extracted Chinese medicinal materials.

[0005] (II) Technical solution

[0006] In a first aspect, the present invention provides a process for extracting rhizomes of Chinese medicinal materials, comprising:

[0007] S1. After picking the rhizomes of Chinese medicinal materials, washing them with water to remove dust, put them into a negative pressure tank and evacuate them. After the negative pressure is maintained at -0.03 to -0.06 MPa for 4-8 minutes, saturated steam is immediately filled into the negative pressure tank until the pressure reaches 1.0-1.1 atm and maintained for 4-8 minutes. The negative pressure tank is opened to export the Chinese medicinal materials.

[0008] S2, cut the Chinese herbal medicine into slices, pellets or segments, and grind them after processing according to the type of herbal medicine and regulatory standards, or grind them directly without processing (only some Chinese herbal medicines need to be processed) and sieve through a 100-mesh sieve to obtain medicinal powder; put the medicinal powder into a high-pressure tank, fully moisten it with a 20-40% ethanol aqueous solution for 0.5-1h, increase the pressure in the container to 5-8atm, maintain the pressure for 2-4min, and quickly open the exhaust valve to instantly reduce the pressure of the high-pressure tank to normal pressure;

[0009] S3, transferring the material discharged from the high-pressure tank to a hot reflux extractor for reflux extraction, and the extractant is selected according to the type of medicinal material; after the extraction is completed, it is placed in a low-temperature tank overnight, separated into layers, and the supernatant is retained;

[0010] S4, coarsely filter the supernatant to remove impurities ≥ 20 microns, add 10-20% of the volume of the filtrate chelating macroporous resin to the filtrate, stir at room temperature, and perform adsorption reaction for 0.5-2h, solid-liquid separation, to obtain a clear solution with heavy metals removed;

[0011] S5. The clear liquid is subjected to microfiltration and ultrafiltration, and is concentrated by multi-effect evaporation under vacuum. The concentrated liquid is adsorbed by a macroporous resin, wherein the macroporous resin is obtained by combining a non-polar macroporous resin, a weakly polar macroporous resin, a medium-polar macroporous resin and a macroporous resin containing a benzene ring; after the adsorption is completed, the macroporous resin is desorbed to produce a desorption liquid; the desorption liquid is concentrated by rotary evaporation, and then frozen or spray-dried to obtain a Chinese medicine extract powder.

[0012] According to a preferred embodiment of the present invention, in S1, the Chinese medicinal materials are picked by manual picking or automatic picking device, and the picking indicators include: foreign matter (removing harmful substances that may be mixed in, such as metal fragments, plastic, glass, etc.), abnormal color (there should be no discoloration, mold or other abnormal color), abnormal specific gravity (there should be no hollow or non-drug impurities wrapped inside), shape integrity (there should be no obvious deformation, damage, or insect bites) and abnormal odor (there should be no peculiar or pungent odor).

[0013] According to a preferred embodiment of the present invention, in S3, when the type of medicinal material is suitable for extraction with water, the ethanol in the material discharged from the high-pressure tank is evaporated, and then the material is transferred to a hot reflux extractor for reflux extraction; when the type of medicinal material is suitable for extraction with ethanol, the solvent in the material discharged from the high-pressure tank is evaporated dry by rotary evaporation, and then mixed with 2-4 times the volume of ethanol and transferred to a hot reflux extractor for reflux extraction; when the type of medicinal material is suitable for extraction with an ethanol-water mixture, water or ethanol is added to the material discharged from the high-pressure tank to adjust the ratio of ethanol and water, and then the material is transferred to a hot reflux extractor for reflux extraction.

[0014] According to a preferred embodiment of the present invention, in S3, sterilization is performed before the heat reflux extraction: the material discharged from the high pressure tank is sterilized by gamma rays. In order to avoid denaturation of the active ingredients, the sterilization conditions are 4-8°C and 10-15Gy of irradiation dose for sterilization.

[0015] According to a preferred embodiment of the present invention, in S3, when extracting with water, the hot reflux extraction temperature is 60-100°C; when extracting with ethanol or ethanol-water mixture, the hot reflux extraction temperature is 60-80°C; the hot reflux extraction time is 2-3h.

[0016] According to a preferred embodiment of the present invention, in S3, when the liquid medicine is left standing overnight in the low-temperature tank, the temperature of the liquid medicine in the low-temperature tank does not exceed 15°C, which promotes precipitation on the one hand and prevents denaturation of the liquid medicine on the other hand.

[0017] According to a preferred embodiment of the present invention, in S4, the coarse filtration is performed by using a sand filter tank or a bag filter; the chelating macroporous resin is a macroporous resin containing aminophosphoric acid, mercapto or pyridyl compatibility groups. This type of chelating macroporous resin can specifically bind heavy metal ions and has strong selectivity and adsorption capacity for heavy metal ions. The chelating macroporous resin for solid-liquid separation is regenerated by acid washing and reused, and the heavy metal ions washed by acid washing are precipitated and harmlessly treated.

[0018] Among them, aminophosphoric acid functionalized resin selectively adsorbs Pb 2+ 、Cd 2+ , Cu 2+ 、Zn 2+ , etc.; Mercapto-functionalized resins selectively adsorb Hg 2+ 、Ag + , Cu 2+ 、Cd 2+ , Pb 2+ ; Pyridyl-functionalized resin selectively adsorbs Ni 2+ 、Co 2+ , Cu 2+ 、Zn 2 + 、Cd 2+ etc.; Chelating macroporous resins mainly bind heavy metal ions specifically, which rely on the ion exchange mechanism, that is, they bind to metal ions through coordination bonds, while organic molecules such as ketones, phenols, terpenes and other active ingredients of traditional Chinese medicines tend to be adsorbed through hydrogen bonds, van der Waals forces or other intermolecular forces. Therefore, these chelating macroporous resins have poor adsorption capacity for active ingredients of traditional Chinese medicines such as ketones, phenols, terpenes, etc., and only a small amount of active ingredients of traditional Chinese medicines will be lost when heavy metals are removed in step S4.

[0019] According to a preferred embodiment of the present invention, in S4, solid-liquid separation is performed using a centrifuge at 3000 rpm for 30-40 min.

[0020] According to a preferred embodiment of the present invention, in S5, the clear liquid is subjected to microfiltration and ultrafiltration, and the pore size of the microfiltration membrane is 0.1 μm to 0.22 μm; the ultrafiltration molecular weight cutoff is 50 kDa or 100 kDa. The 50 kDa ultrafiltration membrane can ensure that most small molecule Chinese medicine extract components (such as ketones, phenols, acids, terpenes, alkaloids, etc.) can pass through; and when the molecular weight cutoff is 100 KDa, not only ketones, phenols, acids, terpenes, alkaloids, etc. can pass through, but also most saponins and polysaccharides can pass through. Therefore, when using, it is selected according to the main chemical composition of the active ingredients of Chinese medicinal materials. If the active ingredients do not contain saponins or polysaccharides, an ultrafiltration membrane with an ultrafiltration molecular weight cutoff of 50 kDa is used; if the active ingredients contain saponins or polysaccharides, an ultrafiltration membrane with an ultrafiltration molecular weight cutoff of 100 kDa is used, thereby taking into account the purity and yield of the extract.

[0021] Microfiltration (MF) can remove suspended solids, such as larger particles such as bacteria, yeast, mold spores, and fine plant fibers; ultrafiltration (UF) can remove macromolecular substances: such as proteins, polysaccharides, pectin, and some pigments. High molecular weight organic matter. Microfiltration can improve the transparency of the clear liquid, reduce the risk of contamination in subsequent processes, provide cleaner feed liquid for ultrafiltration, and extend the service life of the ultrafiltration membrane. Ultrafiltration can retain the target small molecule active ingredients while removing macromolecular impurities, achieving a concentration effect. After microfiltration and ultrafiltration, the multi-effect evaporator can be protected from contamination and protein, pectin or polysaccharides attached to the evaporator surface, reducing the nonspecific adsorption of macroporous resin adsorption.

[0022] According to a preferred embodiment of the present invention, in S5, since the active ingredients of Chinese medicinal materials are complex, including flavonoids (such as quercetin, kaempferol, rutin, etc.), alkaloids (ephedrine, berberine, aconitine, etc.), saponins (ginsenosides, notoginseng saponins, etc.), polysaccharides (Ganoderma lucidum polysaccharides, Astragalus polysaccharides, etc.), volatile oils (menthol, eucalyptol, etc.), terpenes (paclitaxel, artemisinin, etc.), phenols (chlorogenic acid, tanshinone, etc.), organic acids (citric acid, succinic acid, etc.), steroids (such as glycyrrhizic acid, etc.) and anthraquinones (such as rhubarb, etc.), Moreover, a Chinese herbal medicine often contains multiple active ingredients. Therefore, when the concentrate is purified by macroporous resin adsorption, the macroporous resin is obtained by combining non-polar macroporous resin, weak polar macroporous resin, medium polar macroporous resin and macroporous resin containing benzene ring. This macroporous resin uses a macroporous resin with a particle size of 1.0-1.6mm, which can be directly mixed with the concentrate for adsorption and then filtered and separated. The separation operation of large-particle macroporous resin is simple, fast and low-cost. It only needs to add the resin directly to the concentrate, stir and adsorb, and then filter. Compared with the structure of forming an adsorption column, the equipment investment is small and there is almost no maintenance cost.

[0023] According to a preferred embodiment of the present invention, in S5, the polar macroporous resin containing a benzene ring is HP-20 or SP-850, and this macroporous resin has good adsorption for sugars, phenols and active substances containing aromatic groups; the medium polar macroporous resin is AB-8 or D101, and this macroporous adsorption resin can effectively adsorb ketone compounds; the weak polar macroporous resin is NKA-9 or XAD-7, and this macroporous adsorption resin is particularly easy to adsorb saponins; the non-polar macroporous resin is XAD-16 or XAD-7HP, and this macroporous adsorption resin can easily adsorb terpene compounds.

[0024] In actual application, the combination ratio of the above four macroporous resins is set according to the ratio of the main components of the medicinal materials in the concentrate. For example, if the concentrate contains a large amount of polysaccharides, more HP-20 or SP-850 is used; if the concentrate contains more saponins, a larger proportion of NKA-9 or XAD-7 is used.

[0025] The macroporous resin is desorbed by any one of water, ethanol, ethanol-water combination, acidified water (glacial acetic acid), and acidified (glacial acetic acid) ethanol-water combination.

[0026] Among them, the resin containing a benzene ring structure enhances the π-π interaction and has high adsorption to the Chinese herbal medicine extracts containing phenolic or flavonoid components. The present invention combines and uses macroporous resins of various polarity levels when purifying Chinese herbal medicine extracts, so that the process of the present invention can simultaneously process a variety of root and stem Chinese herbal medicines.

[0027] (III) Beneficial effects

[0028] 1. The present invention aims at the problem of tough cell walls of rhizome Chinese medicinal materials. After negative pressure treatment, saturated steam is used to moisten the medicine, so that the medicine becomes soft and easy to slice, diced or cut. On the one hand, it can reduce the wear of the tool. On the other hand, it increases the permeability of the cell walls of rhizome medicinal materials, which is beneficial to the subsequent processing process and improves the adequacy of the medicinal material processing, such as increasing the efficacy, adjusting the site of action of the drug, reducing / eliminating toxicity, changing the medicinal properties, correcting bad odors, etc. Further, due to the problem that the cell walls of rhizome medicinal materials are tough and not easy to leach active ingredients, the present invention uses 20-40% ethanol aqueous solution to fully infiltrate and pressurize to 5-8atm and then quickly release the pressure, so that the cell wall and cell membrane structure are destroyed, and the outflow of cell contents is promoted. Among them, ethanol can effectively extract water from the inside of the cell, causing cell dehydration and shrinkage, thereby aggravating the fragility of the cell wall and more effectively destroying the cell structure. Ethanol is easy to remove, reducing the risk of residues, and will not destroy the active ingredients. It is harmless to the human body at low concentrations and has good biocompatibility.

[0029] 2. In view of the problem that heavy metals are easily accumulated during the cultivation of Chinese medicinal materials, the present invention uses a chelating macroporous resin to adsorb the extract after coarse filtration, which can remove almost all heavy metal ions that enter the extract, so as to ensure that the Chinese medicinal extract contains no or only very low levels of heavy metals, thereby improving the safety of the Chinese medicinal extract.

[0030] 3. In view of the problem that there are many and complex impurities in Chinese herbal medicine extracts, the present invention uses microfiltration and ultrafiltration successively, and selects an appropriate ultrafiltration cut-off molecular weight to reduce the nonspecific adsorption of subsequent macroporous resins, reduce the content of impurities such as pigments, tannins, proteins, etc. in Chinese herbal medicine extract powders, and improve the purity of the extracts. Among them, by combining macroporous resins of various polarity levels, it is possible to extract Chinese herbal medicine extracts with complex components with high yields as much as possible. The method of the present invention can be applied to the extraction process of almost all types of rhizome Chinese herbal medicines, and can improve the recovery rate of effective components of Chinese herbal medicines while ensuring the quality grade and safety of effective Chinese herbal medicine extracts. DETAILED DESCRIPTION

[0031] In order to better explain the present invention and facilitate understanding, the present invention is described in detail below in conjunction with specific implementation methods.

[0032] Example 1

[0033] The present embodiment provides an extraction process for the medicinal components of Angelica sinensis. The active ingredients of Angelica sinensis include ligustilide, ferulic acid, caffeic acid, angelica polysaccharides, apigenin, luteolin, and succinic acid. Angelica sinensis can be extracted with water or ethanol. Water extraction mainly extracts polysaccharides (angelica polysaccharides), phenolic acids (such as ferulic acid) and organic acids (succinic acid). Ethanol extraction mainly extracts non-polar and semi-polar components such as volatile oils (ligustilide), phenolic acids, flavonoids, and some polysaccharides. Water extraction is used in the present embodiment. During actual extraction, selection can be made according to the target medicinal component. The extraction process of the present embodiment is as follows:

[0034] (1) After selecting and washing the angelica sinensis with water to remove dust, the angelica sinensis is placed in a vacuum tank and evacuated to maintain the negative pressure at -0.03 to -0.06 MPa for 4 minutes. Saturated steam is immediately filled into the vacuum tank until the pressure reaches 1.05 atm and maintained for 4 minutes. The vacuum tank is opened and the Chinese medicinal materials are discharged.

[0035] (2) After slicing the angelica, it does not need to be processed, but is directly dried, and then crushed into powder that can pass through a 100-mesh sieve to obtain a powder; the powder is placed in a high-pressure tank, fully moistened with a 33% ethanol aqueous solution for 30 minutes, and the pressure in the container is increased to 5 atm. After maintaining the pressure for 2 minutes, the exhaust valve is quickly opened to instantly reduce the pressure of the high-pressure tank to normal pressure.

[0036] (3) The material discharged from the high-pressure tank is stirred at room temperature to evaporate the ethanol, and then transferred to a hot reflux extractor for reflux extraction at an extraction temperature of 80-90°C for 3 hours. After the extract is cooled, it is placed in a low-temperature tank at 4-10°C and allowed to stand overnight, separated into layers, and the supernatant is discharged.

[0037] (4) The supernatant is filtered using a sand filter tank to remove impurities ≥ 20 microns, and a macroporous resin containing aminophosphoric acid, thiol or pyridyl compatibility groups is added to the filtrate at a volume of 15% of the filtrate. The adsorption reaction is carried out for 1 hour under normal temperature stirring, and the supernatant is centrifuged at 3000 rpm to obtain a clear liquid with heavy metals removed. The separated solid is regenerated with a dilute acid solution and reused.

[0038] (5) The clear liquid is subjected to microfiltration and ultrafiltration, and the ultrafiltration cutoff molecular weight is 100 KDa (the extract contains Angelica polysaccharide). The filtrate is concentrated by multi-effect evaporation under vacuum, and the concentrate is adsorbed by a combination of macroporous resins HP-20, AB-8, NKA-9, and XAD-7HP in a volume ratio of 5:3:1:1. The particle size of the macroporous resin is 1.0-1.6 mm. After adsorption at room temperature for 1 hour, the macroporous resin is separated and desorbed with water. The desorbed liquid is concentrated by negative pressure rotary evaporation at 70°C into a thick paste, and freeze-dried to obtain Angelica extract powder.

[0039] Example 2

[0040] The present embodiment provides an extraction process for the drug components of Bupleurum, and the active ingredients of Bupleurum include saikosaponins a, b1, b2, c, d, etc., volatile oils such as α-pinene and β-pinene, flavonoids such as apigenin, luteolin, quercetin, bupleurum polysaccharides, ferulic acid, caffeic acid, chlorogenic acid, β-sitosterol, and amino acids. Bupleurum can be extracted with water, and the water extract products are mainly components such as bupleurum polysaccharides, ferulic acid, and chlorogenic acid. The ethanol extract of Bupleurum is mainly saponins (saponins a, b1, b2, c, d, etc.), flavonoids (apigenin, luteolin, quercetin), α-pinene, β-pinene, ferulic acid, chlorogenic acid, etc. Therefore, the alcohol extract of Bupleurum contains more types. In practical applications, the appropriate extraction method can be selected according to the required therapeutic effect of the extract. In this embodiment, ethanol is used for extraction, and the process is as follows:

[0041] (1) After picking the Bupleurum Root and washing it with water to remove dust, put it into a vacuum tank and evacuate it. Keep the negative pressure at -0.03 to -0.06 MPa for 4 minutes. Immediately fill the vacuum tank with saturated steam until the pressure reaches 1.05 atm and keep it for 4 minutes. Open the vacuum tank and drain the Chinese herbal medicine.

[0042] (2) After cutting the radix bupleuri into thin slices, the radix bupleuri is directly dried without processing, and then crushed into powder that can be passed through a 100-mesh sieve to obtain a powder; the powder is placed in a high-pressure tank, fully moistened with a 20% ethanol aqueous solution for 30 minutes, and the pressure in the container is increased to 5 atm. After maintaining the pressure for 2 minutes, the exhaust valve is quickly opened to instantly reduce the pressure of the high-pressure tank to normal pressure.

[0043] (3) After the solvent in the material discharged from the high-pressure tank is evaporated, it is mixed with 3 times the volume of ethanol and transferred to a hot reflux extractor for reflux extraction at a temperature of 70-75°C for 3 hours. After the extract is cooled, it is placed in a low-temperature tank at 4-10°C and allowed to stand overnight, separated into layers, and the supernatant is discharged.

[0044] (4) The supernatant is filtered using a sand filter tank to remove impurities ≥ 20 microns, and a macroporous resin containing aminophosphoric acid, thiol or pyridyl compatibility groups is added to the filtrate at a volume of 15% of the filtrate. The adsorption reaction is carried out for 1 hour under normal temperature stirring, and the supernatant is centrifuged at 3000 rpm to obtain a clear liquid with heavy metals removed. The separated solid is regenerated with a dilute acid solution and reused.

[0045] (5) The clear liquid is subjected to microfiltration and ultrafiltration, and the ultrafiltration cutoff molecular weight is 100 KDa (the extract contains bupleurum saponin). The filtrate is concentrated by multi-effect evaporation under vacuum, and the concentrate is adsorbed by a combination of macroporous resins XAD-7, XAD-16, D101, and SP-850 in a volume ratio of 4:2:3:1. The particle size of the macroporous resin is 1.0-1.6 mm. After stirring and adsorbing for 1 hour at room temperature, the macroporous resin is separated and desorbed with ethanol water. The desorbed liquid is concentrated by negative pressure rotary evaporation at 70°C into a thick paste, and freeze-dried to obtain bupleurum extract powder.

[0046] The angelica extract powder of Example 1 and the bupleurum extract powder of Example 2 were tested using a portable X-ray fluorescence spectrometer. The products did not contain common heavy metal element residues such as Hg, Ag, Cu, Pb, Cd, Zn, and Cr. The extract powder of Example 1 was dissolved in water, and the extract powder of Example 2 was dissolved in ethanol. No protein component was detected, and the dissolved solution was very clear and transparent. There were no obvious suspended particles or precipitations when observed with the naked eye. The turbidity of the dissolved solution was less than 0.1NTU when analyzed using a turbidity meter. The transmittance of the dissolved solution was >93% when tested using a transmittance meter.

[0047] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions described in the above embodiments may still be modified, or some or all of the technical features therein may be replaced by equivalents. These modifications or replacements, or the technical features in the above embodiments may be combined in the manner described in the embodiments if they do not conflict with each other, and these modifications, replacements or combinations do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A process for extracting rhizomes of Chinese medicinal materials, characterized in that: It includes: S1. After picking the rhizomes of Chinese medicinal materials, washing them with water to remove dust, put them into a negative pressure tank and evacuate them. After the negative pressure is maintained at -0.03 to -0.06 MPa for 4-8 minutes, saturated steam is immediately filled into the negative pressure tank until the pressure reaches 1.0-1.1 atm and maintained for 4-8 minutes. The negative pressure tank is opened to export the Chinese medicinal materials. S2. Slice, pelletize or segment the Chinese herbal medicine, process it according to the type of herbal medicine and regulatory standards, and then crush it or directly crush it without processing and sieve it through a 100-mesh sieve to obtain a powder; put the powder into a high-pressure tank, fully moisten it with a 20-40% ethanol aqueous solution for 0.5-1h, increase the pressure in the container to 5-8atm, maintain the pressure for 2-4min, and then quickly open the exhaust valve to instantly reduce the pressure of the high-pressure tank to normal pressure; S3, transferring the material discharged from the high-pressure tank to a hot reflux extractor for reflux extraction, and the extractant is selected according to the type of medicinal material; After the extraction is completed, the mixture is placed in a low-temperature tank overnight, separated into layers, and the supernatant is retained; S4, coarsely filter the supernatant to remove impurities ≥ 20 microns, add 10-20% of the volume of the filtrate chelating macroporous resin to the filtrate, stir at room temperature, and perform adsorption reaction for 0.5-2h, solid-liquid separation, to obtain a clear solution with heavy metals removed; S5. The clear liquid is subjected to microfiltration and ultrafiltration, and is concentrated by multi-effect evaporation under vacuum. The concentrated liquid is adsorbed by a macroporous resin, wherein the macroporous resin is obtained by combining a non-polar macroporous resin, a weakly polar macroporous resin, a medium-polar macroporous resin and a macroporous resin containing a benzene ring; after the adsorption is completed, the macroporous resin is desorbed to produce a desorption liquid; the desorption liquid is concentrated by rotary evaporation, and then frozen or spray-dried to obtain a Chinese medicine extract powder.

2. The extraction process according to claim 1, characterized in that In S1, the Chinese medicinal materials are picked manually or by an automated picking device, and the picking indicators include: foreign matter, abnormal color, abnormal specific gravity, shape integrity and abnormal smell.

3. The extraction process according to claim 1, characterized in that In S3, when the type of medicinal material is suitable for extraction with water, the ethanol in the material discharged from the high-pressure tank is evaporated, and then the material is transferred to a hot reflux extractor for reflux extraction; when the type of medicinal material is suitable for extraction with ethanol, the solvent in the material discharged from the high-pressure tank is evaporated dry by rotary evaporation, and then mixed with 2-4 times the volume of ethanol and transferred to a hot reflux extractor for reflux extraction; when the type of medicinal material is suitable for extraction with an ethanol-water mixture, water or ethanol is added to the material discharged from the high-pressure tank to adjust the ratio of ethanol and water, and then the material is transferred to a hot reflux extractor for reflux extraction.

4. The extraction process according to claim 3, characterized in that: In S3, sterilization is performed before hot reflux extraction: the material discharged from the high-pressure tank is sterilized by gamma rays.

5. The extraction process according to claim 3, characterized in that: In S3, when extracting with water, the hot reflux extraction temperature is 60-100°C; when extracting with ethanol or ethanol-water mixture, the hot reflux extraction temperature is 60-80°C; and the hot reflux extraction time is 2-3h.

6. The extraction process according to claim 1, characterized in that In S3, when the liquid medicine in the low-temperature tank is left standing overnight, the temperature of the liquid medicine in the low-temperature tank does not exceed 15°C.

7. The extraction process according to claim 1, characterized in that In S4, the coarse filtration is performed by using a sand filter tank or a bag filter; the chelating macroporous resin is a macroporous resin containing a compatible group of aminophosphoric acid, mercapto or pyridyl.

8. The extraction process according to claim 1, characterized in that: In S4, a centrifuge is used for solid-liquid separation at 3000 rpm for 30-40 min.

9. The extraction process according to claim 1, characterized in that: In S5, the clear liquid is subjected to microfiltration and ultrafiltration, the pore size of the microfiltration membrane is 0.1 μm to 0.22 μm, and the molecular weight cutoff of the ultrafiltration is 50 kDa or 100 kDa.

10. The extraction process according to claim 1, characterized in that: In S5, the macroporous resin has a particle size of 1.0-1.6 mm; the macroporous resin containing benzene rings is HP-20 or SP-850; the medium-polar macroporous resin is AB-8 or D101; the weak-polar macroporous resin is NKA-9 or XAD-7; and the non-polar macroporous resin is XAD-16 or XAD-7HP.