Astragalus mongholicus fermentation method and application
By making Astragalus into a fermentation broth, the problem that traditional Astragalus cannot change the active ingredients is solved, the medicinal effect is enhanced and the biologically active substances are increased, making the application of Astragalus in health products and traditional Chinese medicine drugs more convenient and safe.
Patent Information
- Application Number
- CN202411964908.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2025-03-21
AI Technical Summary
When used, traditional astragalus cannot change its active ingredients, resulting in inconvenient application in different fields.
Astragalus fermentation broth is prepared by drying, crushing and fermenting fresh astragalus. The method includes steps such as: crushing dry astragalus, mixing with water, adding enzymes and microorganisms for fermentation, separating solid-liquid, filtration and filling, and finally obtaining Astragalus fermentation broth.
Through fermentation treatment, the active ingredients of Astragalus are changed, the efficacy of the medicine is enhanced, the biologically active substances are increased, and the microorganisms enhance immunity and regulate intestinal balance, reducing the toxicity or irritation of medicinal materials, making Astragalus more suitable for use in industries such as health products and traditional Chinese medicine.
Smart Images
Figure CN119656218A_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of astragalus fermentation liquid, and specifically to an astragalus fermentation method and application. Background Art
[0002] Astragalus is a plant of the genus Astragalus in the leguminous family. Astragalus has the effects of tonifying Qi and raising Yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid production and nourishing blood, relieving stagnation and relieving numbness, expelling toxins and discharging pus, and healing sores and promoting tissue regeneration. It is mainly used to treat all symptoms of Qi deficiency and blood deficiency, and can be used to treat Qi deficiency and fatigue, poor appetite and loose stools, sinking of Qi in the middle, long-term diarrhea and prolapse of the anus, spontaneous sweating due to exterior deficiency, edema, internal heat and thirst, blood deficiency and sallow complexion, pain and numbness, carbuncles that are difficult to heal, long-term ulcers that do not heal, and cough due to lung deficiency.
[0003] Traditionally, astragalus is usually ground into fine powder or sliced directly, and then taken by soaking in water or boiling. However, the effective ingredients of astragalus itself cannot be changed during the soaking and boiling process, which makes it inconvenient to use astragalus in different fields. Therefore, a fermentation method and application of astragalus are proposed to address the above problems. Summary of the invention
[0004] The purpose of the present application is to provide a fermentation method and application of Astragalus, so as to solve the problem that Astragalus is inconvenient to be applied in various fields.
[0005] To achieve the above objectives, this application provides the following technical solutions: A fermentation method and application of astragalus, comprising the following steps: Step 1: drying and dehydrating fresh astragalus to form dry astragalus, and then putting the dry astragalus into a grinding device for grinding. After the grinding is completed, the astragalus powder is sieved to separate the astragalus fine powder from the astragalus granules, and then the astragalus fine powder is collected, and the astragalus granules and astragalus blocks are sent to the grinding device for grinding; Step 2: put the astragalus powder into the fermentation tank according to the prescribed amount, then add 15 times the amount of water in the prescribed amount of astragalus powder into the fermentation tank, and then stir evenly; Step 3: Take 3% of the amount of cellulase, hemicellulase and saccharifying enzyme of the prescription of astragalus powder, and then dissolve them in water respectively, and then add the cellulase, hemicellulase and saccharifying enzyme mixed with water into the fermentation tank in turn and stir evenly; Step 4: Take 1% of the amount of neutral protease in the prescription of astragalus powder, and then dissolve it with water. Then, add the neutral protease mixed with water into the fermentation tank, open the steam valve, and perform enzymolysis on the liquid; Step 5: After the enzymatic hydrolysis is completed, the steam valve of the fermentation tank is opened to heat the fermentation tank to inactivate the liquid. After the enzymatic hydrolysis is completed, the steam valve is closed, and the circulating water valve is opened to cool the fermentation tank to form an enzymatic hydrolyzate; Step 6: adding an appropriate amount of one or more of Lactobacillus plantarum, Bifidobacterium lactis, Lactobacillus rhamnosus and Lactobacillus reuteri to the enzymolysis solution in the fermentation tank, inoculating the enzymolysis solution with bacterial strains, opening the steam valve for culturing, then sampling the enzymolysis solution in the fermentation tank, detecting the pH value of the enzymolysis solution sample, and stopping the fermentation when the pH value is less than 4; Step 7: sending the fermented mixed liquid to a tubular centrifuge, separating the mixed liquid into solid and liquid by the tubular centrifuge, collecting the centrifuge, and finally taking out the solid and drying it for collection; Step 8: heating the centrifuge liquid to boil, and then cooling it to room temperature, and obtaining the finished product of the astragalus fermentation liquid after the centrifuge liquid is cooled to room temperature; Step nine: filtering the astragalus fermented liquid, passing the filtered astragalus fermented liquid into a filling machine, and then filling it according to the standard of 30 ml, and then sealing the filled astragalus fermented liquid container, and finally directly loading the unfilled astragalus fermented liquid into a raw material barrel for refrigerated storage; Step 10: Send the filled Astragalus fermented liquid into the sterilization equipment for sterilization and leak detection, package the Astragalus fermented liquid after it is cooled to room temperature, and finally store the packaged Astragalus fermented liquid in the warehouse.
[0006] Preferably, during the astragalus processing process, the fresh astragalus is cleaned with clean water, and then the water on the surface of the astragalus is wiped dry, and then the fresh astragalus is placed in a ventilated and dry room to air-dry, and then the air-dried astragalus is placed in an electric drying oven, and the astragalus is dried in the electric drying oven at 45-50°C for more than 12 hours to make dry astragalus, and then the dry astragalus is cut into pieces and crushed by a grinder to make astragalus fine powder.
[0007] Preferably, the temperature in the fermentation tank in step 3 is controlled at 50° C., and the stirring and enzymolysis time is 3 hours.
[0008] Preferably, the temperature in the fermentation tank in step 4 is controlled at 55° C., and the stirring and enzymolysis time is 2 hours.
[0009] Preferably, during the enzymatic inactivation in step 5, the temperature in the fermentation tank rises to 115° C. and is maintained for 20 minutes, the temperature of the enzymatic hydrolyzate is 20-24° C., and the pressure in the tank is 0.
[0010] Preferably, in step six, the temperature in the fermentation tank is controlled at 37.5 degrees Celsius and the culture time is 60-72 hours.
[0011] Preferably, the centrifuge collected in step seven is 12-13 times the amount of the astragalus powder during processing.
[0012] Preferably, the heating and boiling time of the centrifuge in step eight is 10 minutes. After cooling to room temperature, the centrifuge should be 12 times the amount of the astragalus powder used during processing. If the centrifuge is less than 12 times the amount of the astragalus powder used, an appropriate amount of boiled purified water is added to the centrifuge to make the centrifuge reach 12 times the amount of the astragalus powder used during processing.
[0013] Preferably, in step 10, the temperature at which the sterilizing equipment heats the Astragalus fermented liquid is 100° C. for 30 minutes, thereby sterilizing and leak-checking the Astragalus fermented liquid.
[0014] Preferably, the fermented Astragalus membranaceus liquid is used in health products and traditional Chinese medicines. Compared with the prior art, the beneficial effects of this application are: In the present application, by making Astragalus powder into fermentation liquid, the effective ingredients can be changed, the efficacy can be enhanced, and it is beneficial to the treatment of diseases. At the same time, the ingredients in the fermented Chinese medicine will change accordingly. The Astragalus fermentation liquid will contain some biologically active substances. The microorganisms used for fermenting Chinese medicine are strains that are beneficial to the animal body. They themselves have the functions of enhancing immunity, regulating intestinal balance, and improving production performance. Compared with the original medicine, the Chinese medicine produces new active substances after mixed fermentation of these multiple strains, mainly some secondary metabolites, which can promote gastrointestinal absorption after taking. The toxicity or irritation in the medicinal materials is reduced through fermentation, making it safer to take Astragalus, thereby producing new health care, prevention and treatment effects, making Astragalus more convenient to use in health care products and traditional Chinese medicine and other industries. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 This is a schematic diagram of the Astragalus fermentation prescription of this application; Figure 2 This is a schematic diagram of the Astragalus fermentation process for this application. DETAILED DESCRIPTION
[0016] See also Figure 1-2 , this application provides a technical solution: A fermentation method and application of astragalus, comprising the following steps: Step 1: clean the fresh astragalus with clean water, wipe the water off the surface of the astragalus, and then air-dry the fresh astragalus in a ventilated and dry room, and then put the air-dried astragalus into an electric drying oven, and dry the astragalus at 45-50°C for more than 12 hours in the electric drying oven to make dry astragalus, and then cut the dry astragalus into pieces, and grind it into fine astragalus powder by a grinder, sieve the astragalus powder, separate the fine astragalus powder from the astragalus granules, and then collect the fine astragalus powder, and send the astragalus granules and astragalus blocks into a grinding device for grinding; Step 2: put the astragalus powder into the fermentation tank according to the prescribed amount, then add 15 times the amount of water in the prescribed amount of astragalus powder into the fermentation tank, and then stir evenly; Step 3: Take 3% of the amount of cellulase, hemicellulase and saccharifying enzyme of the prescription of astragalus powder, and then dissolve them in water respectively, then add the cellulase, hemicellulase and saccharifying enzyme mixed with water into the fermentation tank in turn, start the fermentation tank to stir the liquid, then open the steam valve, control the temperature in the fermentation tank at 50°C, and stir the enzymolysis for 3 hours; Step 4: Take 1% of the amount of neutral protease in the prescription of Astragalus powder, and then dissolve it with water. Then add the neutral protease mixed with water into the fermentation tank, and then control the temperature in the fermentation tank at 55°C, and continue to stir and enzymolyze for 2 hours; Step 5: Open the steam valve of the fermenter to raise the temperature in the fermenter to 115°C and maintain it for 20 minutes to inactivate the liquid. After the enzymatic inactivation is completed, close the steam valve. When the pressure in the fermenter is 0, open the circulating water valve to reduce the temperature of the fermenter to 20-24°C to form an enzymatic solution. Step 6: adding an appropriate amount of one or more of Lactobacillus plantarum, Bifidobacterium lactis, Lactobacillus rhamnosus and Lactobacillus reuteri to the enzymolysis solution in the fermentation tank, inoculating the enzymolysis solution with bacteria, opening the steam valve, and controlling the temperature in the fermentation tank at 37.5° C., culturing for 60-72 hours, then sampling the enzymolysis solution in the fermentation tank, detecting the pH value of the enzymolysis solution sample, and stopping the fermentation when the pH value is less than 4; Step 7: sending the fermented mixed liquid to a tubular centrifuge, separating the mixed liquid into solid and liquid by the tubular centrifuge, collecting the centrifuge liquid, the collected centrifuge liquid is 12-13 times the amount of the astragalus powder during processing, and finally taking out the solid and drying it for collection; Step 8: heating and boiling the centrifuge for 10 minutes, and then cooling to room temperature. After the centrifuge is cooled to room temperature, the centrifuge should be 12 times the amount of the astragalus powder used in the processing. If the centrifuge is less than 12 times the amount of the astragalus powder used, add an appropriate amount of boiled purified water to the centrifuge to make the centrifuge reach 12 times the amount of the astragalus powder used in the processing, thereby obtaining the finished astragalus fermentation liquid; Step nine: filtering the astragalus fermented liquid, passing the filtered astragalus fermented liquid into a filling machine, and then filling it according to the standard of 30 ml, and then sealing the filled astragalus fermented liquid container, and finally directly loading the unfilled astragalus fermented liquid into a raw material barrel for refrigerated storage; Step 10: Send the filled Astragalus fermented liquid into the sterilization equipment, heat the filled Astragalus fermented liquid to 100°C and maintain it for 30 minutes, so as to sterilize and leak-check the Astragalus fermented liquid, package it after it cools to room temperature, and finally store the packaged Astragalus fermented liquid in the warehouse.
[0017] By making Astragalus powder into fermentation liquid, the effective ingredients can be changed, the efficacy can be enhanced, and it is beneficial to the treatment of diseases. At the same time, the ingredients in the fermented Chinese medicine will change accordingly. The Astragalus fermentation liquid will contain some biologically active substances. The microorganisms used to ferment Chinese medicine are strains that are beneficial to the animal body. They themselves have the functions of enhancing immunity, regulating intestinal balance, and improving production performance. Compared with the original drugs, the Chinese medicine produces new active substances after mixed fermentation of these multiple strains, mainly some secondary metabolites, which can promote gastrointestinal absorption after taking them. The toxicity or irritation in the medicinal materials can be reduced through fermentation, making it safer to take Astragalus, thereby producing new health care, prevention and treatment effects, making Astragalus more convenient to use in health care products and traditional Chinese medicine and other industries.
[0018] This article uses specific examples to illustrate the principles and implementation methods of this application. The above examples are only used to help understand the method and its core ideas of this application. The above is only the preferred implementation method of this application. It should be pointed out that due to the limitations of textual expression and the objective existence of infinite specific structures, ordinary technicians in this technical field can make several improvements, modifications or changes without departing from the principles of this application, and can also combine the above technical features in an appropriate manner; these improvements, modifications, changes or combinations, or the direct application of the inventive concept and technical solution to other occasions without improvement, should be regarded as the scope of protection of this application.
Claims
1. A fermentation method of Astragalus, characterized in that: The following steps are involved: Step 1: drying and dehydrating fresh astragalus to form dry astragalus, and then putting the dry astragalus into a grinding device for grinding. After the grinding is completed, the astragalus powder is sieved to separate the astragalus fine powder from the astragalus granules, and then the astragalus fine powder is collected, and the astragalus granules and astragalus blocks are sent to the grinding device for grinding; Step 2: put the astragalus powder into the fermentation tank according to the prescribed amount, then add 15 times the amount of water in the prescribed amount of astragalus powder into the fermentation tank, and then stir evenly; Step 3: Take 3% of the amount of cellulase, hemicellulase and saccharifying enzyme of the prescription of astragalus powder, and then dissolve them in water respectively, and then add the cellulase, hemicellulase and saccharifying enzyme mixed with water into the fermentation tank in turn and stir evenly; Step 4: Take 1% of the amount of neutral protease in the prescription of astragalus powder, and then dissolve it with water. Then, add the neutral protease mixed with water into the fermentation tank, open the steam valve, and perform enzymolysis on the liquid; Step 5: After the enzymatic hydrolysis is completed, the steam valve of the fermentation tank is opened to heat the fermentation tank to inactivate the liquid. After the enzymatic hydrolysis is completed, the steam valve is closed, and the circulating water valve is opened to cool the fermentation tank to form an enzymatic hydrolyzate; Step 6: adding an appropriate amount of one or more of Lactobacillus plantarum, Bifidobacterium lactis, Lactobacillus rhamnosus and Lactobacillus reuteri to the enzymolysis solution in the fermentation tank, inoculating the enzymolysis solution with bacterial strains, opening the steam valve for culturing, then sampling the enzymolysis solution in the fermentation tank, detecting the pH value of the enzymolysis solution sample, and stopping the fermentation when the pH value is less than 4; Step 7: sending the fermented mixed liquid to a tubular centrifuge, separating the mixed liquid into solid and liquid by the tubular centrifuge, collecting the centrifuge, and finally taking out the solid and drying it for collection; Step 8: heating the centrifuge liquid to boil, and then cooling it to room temperature, and obtaining the finished product of the astragalus fermentation liquid after the centrifuge liquid is cooled to room temperature; Step nine: filtering the astragalus fermented liquid, passing the filtered astragalus fermented liquid into a filling machine, and then filling it according to the standard of 30 ml, and then sealing the filled astragalus fermented liquid container, and finally directly loading the unfilled astragalus fermented liquid into a raw material barrel for refrigerated storage; Step 10: Send the filled Astragalus fermented liquid into the sterilization equipment for sterilization and leak detection, package the Astragalus fermented liquid after it is cooled to room temperature, and finally store the packaged Astragalus fermented liquid in the warehouse.
2. The fermentation method of Astragalus according to claim 1, characterized in that: During the Astragalus processing process, the fresh Astragalus is cleaned with clean water, and then the water on the surface of the Astragalus is wiped dry. The fresh Astragalus is then air-dried in a ventilated and dry room. The air-dried Astragalus is then placed in an electric drying oven and dried at 45-50°C for more than 12 hours in an electric drying oven to make dried Astragalus. The dried Astragalus is then cut into pieces and crushed by a grinder to make Astragalus fine powder.
3. The fermentation method of Astragalus according to claim 1, characterized in that: The temperature in the fermentation tank in step 3 is controlled at 50° C., and the stirring and enzymolysis time is 3 hours.
4. The fermentation method of Astragalus according to claim 1, characterized in that: The temperature in the fermentation tank in step 4 is controlled at 55° C., and the stirring and enzymolysis time is 2 hours.
5. The fermentation method of Astragalus according to claim 1, characterized in that: During the enzymatic inactivation in step 5, the temperature in the fermentation tank rises to 115° C. and is maintained for 20 minutes. The temperature of the enzymatic solution is 20-24° C., and the pressure in the tank is 0.
6. The fermentation method of Astragalus according to claim 1, characterized in that: In step six, the temperature in the fermentation tank is controlled at 37.5 degrees Celsius and the culture time is 60-72 hours.
7. The fermentation method of Astragalus according to claim 1, characterized in that: The centrifuge liquid collected in step seven is 12-13 times the amount of the astragalus powder during processing.
8. The fermentation method of Astragalus according to claim 1, characterized in that: In step eight, the heating and boiling time of the centrifuge is 10 minutes. After cooling to room temperature, the centrifuge should be 12 times the amount of the astragalus powder used in processing. If the centrifuge is less than 12 times the amount of the astragalus powder used, add an appropriate amount of boiled purified water to the centrifuge to make the centrifuge reach 12 times the amount of the astragalus powder used in processing.
9. The fermentation method of Astragalus according to claim 1, characterized in that: In step 10, the temperature of the sterilization equipment heating the astragalus fermented liquid is 100° C. and the time is 30 minutes, so as to sterilize and leak-check the astragalus fermented liquid.
10. The use of the fermentation method of Astragalus according to any one of claims 1 to 9, characterized in that: Astragalus fermented liquid is used in health products and traditional Chinese medicines.