Traditional Chinese medicine composition for relieving xerophthalmia and asthenopia as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for relieving xerophthalmia and asthenopia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 40 to 50 parts of herba equiseti hiemalis, 30 to 40 parts of rhizoma chuanxiong, 15 to 35 parts of radix codonopsis, 20 to 25 parts of white chrysanthemum flower, 5 to 8 parts of flos carthami, 10 to 15 parts of semen celosiae, 10 to 20 parts of cortex phellodendri, 5 to 15 parts of folium artemisiae argyi, 3 to 5 parts of herba portulacae, 15 to 25 parts of herba albiziae, 0.5 to 1 part of menthol, 0.5 to 1 part of borneol and 1 to 2 parts of deep sea whole algae extract. The traditional Chinese medicine composition can effectively relieve xerophthalmia and asthenopia, and potential complication risks can be avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for relieving dry eyes and visual fatigue, and a preparation method and application thereof. Background Art

[0002] Dry eye (DE) is a chronic ocular surface disease that generally affects people's vision and quality of life. Dry eye is caused by abnormalities in the quality, quantity and dynamics of tears, resulting in tear film instability or imbalance of the ocular surface microenvironment, often accompanied by ocular surface inflammatory response, tissue damage and nerve abnormalities, which in turn cause a variety of eye discomfort symptoms and / or visual dysfunction. Dry eye can be divided into multiple types, including aqueous deficiency type, lipid abnormality type, mucin abnormality type, tear dynamics abnormality type and mixed type. Among them, lipid abnormality dry eye accounts for 60% to 90% of all dry eye cases, and Meibomian Gland Dysfunction (MGD) is the most common cause of lipid abnormality dry eye.

[0003] Visual fatigue is also a common disease in ophthalmology. Its symptoms include dry eyes, soreness, blurred vision, etc., which will directly affect people's daily work and life. Visual fatigue is mainly caused by staring at a close-up fluorescent screen for a long time, such as a computer screen, mobile phone, etc., which will lead to a decrease in the number of blinks, thereby reducing the secretion of tears. At the same time, the flickering screen will irritate the eyes. In addition, visual fatigue may also cause symptoms such as eye pain, dull pain in the eyeball, and unclear vision. In severe cases, symptoms of blood deficiency and liver fatigue caused by long-term overwork may appear.

[0004] The accelerated pace of life and increased work pressure in modern society have led to an increasing number of patients with dry eye and visual fatigue. The prevalence and high incidence of dry eye and visual fatigue have caused obvious discomfort to patients, such as dryness, burning sensation, foreign body sensation and pain, which seriously affect patients' visual function, daily activities and work.

[0005] Currently, dry eye is mainly treated by artificial tears to lubricate the ocular surface, anti-inflammatory treatment, and antibacterial treatment to reduce inflammation and improve symptoms, but this treatment method has potential complications. For example, the use of hormones and immunosuppressants may cause increased intraocular pressure and cataracts. Treatment of visual fatigue is mainly relieved by asking patients to rest, use their eyes less, and use eye drops, but the effect is limited.

[0006] Therefore, the existing treatment of dry eye has potential complications, and the treatment of visual fatigue has limited effect. Therefore, it is necessary to provide a product that can effectively treat dry eye and visual fatigue while avoiding potential complications. Summary of the invention

[0007] 1. Technical issues to be resolved

[0008] In order to solve the problems in the prior art of treating dry eye syndrome with potential complication risks and limited therapeutic effect on visual fatigue, the present invention provides a Chinese medicine composition for relieving dry eye syndrome and visual fatigue, and a preparation method and application thereof.

[0009] (II) Technical solution

[0010] In order to achieve the above object, the main technical solutions adopted by the present invention include:

[0011] In a first aspect, the present invention provides a traditional Chinese medicine composition for relieving dry eyes and visual fatigue, comprising, by weight, 40-50 parts of horsetail, 30-40 parts of chuanxiong, 15-35 parts of codonopsis, 20-25 parts of white chrysanthemum, 5-8 parts of safflower, 10-15 parts of amaranth, 10-20 parts of phellodendron, 5-15 parts of wormwood, 3-5 parts of purslane, 15-25 parts of scutellaria, 0.5-1 part of menthol, 0.5-1 part of borneol, and 1-2 parts of deep-sea whole algae extract.

[0012] The Chinese medicine composition for relieving dry eyes and visual fatigue as described above preferably comprises, by weight, 45 parts of horsetail, 35 parts of chuanxiong, 25 parts of codonopsis, 22 parts of white chrysanthemum, 6 parts of safflower, 12 parts of amaranth, 15 parts of phellodendron, 12 parts of wormwood, 4 parts of purslane, 20 parts of clematis, 0.5 parts of menthol, 0.5 parts of borneol, and 2 parts of deep-sea whole algae extract.

[0013] In the second aspect, the present invention provides a method for preparing the above-mentioned Chinese medicine composition for relieving dry eyes and visual fatigue, comprising the following steps:

[0014] S1: Wash and crush Equisetum arvense, Rhizoma Chuanxiong, Codonopsis pilosula, Chrysanthemum officinale, Carthamus tinctorius, Fructus Amaranthus, Phellodendron amurense, Folium Artemisiae Argyi, Portulaca oleracea, and Herba Clematidis to obtain a mixed medicinal material, add water to the mixed medicinal material, and perform enzymatic hydrolysis on the mixed medicinal material;

[0015] S2: sterilizing the mixed medicinal materials after enzymatic hydrolysis, and then fermenting them to obtain a fermentation liquid;

[0016] S3: inactivating the fermentation liquid, and then performing ultrasonic low-temperature extraction to obtain an extract;

[0017] S4: extracting the extract to obtain an extract;

[0018] S5: The extract is concentrated under reduced pressure, and then menthol, borneol and deep-sea whole algae extract are added and mixed to obtain a Chinese medicine composition.

[0019] In the method for preparing the Chinese medicine composition for relieving dry eyes and visual fatigue as described above, preferably, in step S1, water and enzymes are added to the mixed medicinal materials to perform enzymatic hydrolysis on the mixed medicinal materials; the enzyme is cellulase, pectinase or neutral protease.

[0020] The method for preparing the Chinese medicine composition for relieving dry eye and visual fatigue as described above, preferably, in step S4, ethanol is added to the extract to perform an alcohol extraction to obtain an alcohol extract; then water is added to the extract after the alcohol extraction, and water extraction is performed twice in sequence to obtain a first water extract and a second water extract respectively;

[0021] The first water extract and the second water extract are mixed to obtain a mixed solution, ethanol is added to the mixed solution for alcohol precipitation and water extraction, and then the mixed solution is allowed to stand, and the precipitate is removed by filtering to obtain a supernatant;

[0022] The alcohol extract and the supernatant are mixed to obtain an extract.

[0023] The method for preparing the Chinese medicine composition for relieving dry eye and visual fatigue as described above, preferably, in step S4, the volume concentration of ethanol used in the first alcohol extraction is 60-95%, the volume of ethanol is 3-5 times the volume of the extract, and the processing time of the first alcohol extraction is 1-3h;

[0024] In the two water extractions, the volume of water is 3-5 times the volume of the extract after the first alcohol extraction, and the processing time of the two water extractions is 1-2h respectively;

[0025] In the alcohol precipitation and water extraction, the volume concentration of ethanol added is 90-95%. After the addition of ethanol, the volume concentration of ethanol in the mixed solution is 60-70%, and the standing time is 20-28 hours.

[0026] In a third aspect, the present invention provides an application of the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the above-mentioned preparation method in a non-woven eye patch. Specifically, glycerol, sodium benzoate and deionized water are added to the traditional Chinese medicine composition, and after uniform mixing, an eye patch liquid is obtained, and a non-woven fabric is immersed in the eye patch liquid to obtain a non-woven eye patch;

[0027] The eye patch solution comprises, by weight percentage, 0.1-0.3% of glycerol, 0.2-0.3% of sodium benzoate and 74-75% of deionized water, and the remainder is a traditional Chinese medicine composition.

[0028] In a fourth aspect, the present invention provides an application of the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the above-mentioned preparation method in a jelly gel eye patch. Specifically, glycerin, carbomer, carrageenan and deionized water are added to the traditional Chinese medicine composition, and the jelly gel eye patch is obtained after uniform mixing;

[0029] The jelly gel eye patch comprises, by weight percentage, 4-5% of glycerol, 0.1-0.2% of carbomer, 0.01-0.02% of carrageenan and 74-75% of deionized water, and the remainder is a traditional Chinese medicine composition.

[0030] In a fifth aspect, the present invention provides an application of the above-mentioned Chinese medicine composition or the Chinese medicine composition prepared by the above-mentioned preparation method in a fumigant. Specifically, sterile water is added to the Chinese medicine composition, and the mixture is heated to obtain a fumigant; wherein the mass ratio of the Chinese medicine composition to sterile water is 1:40-1:50.

[0031] In a sixth aspect, the present invention provides a use of the above-mentioned Chinese medicine composition or the Chinese medicine composition prepared by the above-mentioned preparation method in an eye ointment or atomized liquid, specifically, adding medical vaseline, lanolin and liquid wax to the Chinese medicine composition, mixing evenly, to obtain an eye ointment;

[0032] The application of the Chinese medicine composition in the atomized liquid comprises: adding sodium hyaluronate and sodium chloride to the Chinese medicine composition, mixing evenly, and filtering to obtain the atomized liquid.

[0033] (III) Beneficial effects

[0034] The present invention provides a Chinese medicine composition comprising horsetail, chuanxiong, codonopsis, white chrysanthemum, safflower, cyanus semen, phellodendron, wormwood, purslane, clover, menthol, borneol, and deep-sea whole algae extracts. The Chinese medicine composition can achieve significant therapeutic effects in relieving dry eye and treating visual fatigue. According to clinical statistics, the total effective rate of the Chinese medicine composition in treating dry eye and visual fatigue can reach 90% or more, and there are few adverse reactions, which can avoid potential complications. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 The process flow chart of the preparation method of the Chinese medicine composition for relieving dry eyes and visual fatigue in the present invention;

[0036] Figure 2 This is a statistical chart of the average tear secretion of mice in the blank control group, negative control group, and experimental groups 1-5 after 14 days of administration;

[0037] Figure 3 This is a statistical graph of the total antioxidant capacity (T-AOC) in the lens of each group of mice after 14 days of administration;

[0038] Figure 4 This is a statistical chart of superoxide dismutase (SOD) detection in the liver tissue of each group of mice after 14 days of administration;

[0039] Figure 5This is a statistical chart of the detection of catalase (CAT) in the liver tissue of each group of mice after 14 days of administration. DETAILED DESCRIPTION

[0040] In order to better explain the present invention and facilitate understanding, the present invention is described in detail below in conjunction with specific implementation methods.

[0041] The invention provides a traditional Chinese medicine composition for relieving dry eyes and visual fatigue. The traditional Chinese medicine composition comprises, by weight, 40-50 parts of horsetail, 30-40 parts of chuanxiong, 15-35 parts of codonopsis, 20-25 parts of white chrysanthemum, 5-8 parts of safflower, 10-15 parts of amaranth seeds, 10-20 parts of phellodendron, 5-15 parts of wormwood, 3-5 parts of purslane, 15-25 parts of scutellaria, 0.5-1 part of menthol, 0.5-1 part of borneol and 1-2 parts of deep-sea whole algae extract.

[0042] Preferably, the Chinese medicine composition for relieving dry eyes and visual fatigue of the present invention comprises, by weight, 45 parts of horsetail, 35 parts of chuanxiong, 25 parts of codonopsis, 22 parts of white chrysanthemum, 6 parts of safflower, 12 parts of amaranth, 15 parts of phellodendron, 12 parts of wormwood, 4 parts of purslane, 20 parts of clematis, 0.5 parts of menthol, 0.5 parts of borneol, and 2 parts of deep-sea whole algae extract.

[0043] The prescription of the Chinese medicine composition of the present invention is explained as follows:

[0044] Horsetail is the main drug, sweet, bitter, flat, and enters the lung and liver meridians. It has the effects of dispersing wind and heat, relieving muscles, and removing cataracts. It is used to treat symptoms such as red, swollen, and painful eyes, blurred vision, and dry eyes and visual fatigue. It can relieve eye discomfort through its effects of dispersing wind and heat, relieving the exterior and dispersing cold.

[0045] Chuanxiong and white chrysanthemum are the assistant drugs. Chuanxiong is warm in nature and pungent in taste. It enters the liver, gallbladder and pericardium meridians and has the effects of promoting blood circulation and qi, dispelling wind and relieving pain. Combined with horsetail, it can enhance the effect of dispersing wind and dissipating heat, while promoting blood circulation and qi, improving blood circulation of the eyes and the whole body. White chrysanthemum is sweet and bitter in nature and slightly cold. It enters the lung and liver meridians and has the effects of dispersing wind and heat, calming the liver and improving eyesight. Combined with Chuanxiong, it can enhance the effect of clearing heat and calming the liver, improving eyesight, and assist the main drug in regulating the ascending and descending qi of the liver and lungs to improve the symptoms of headache, dizziness, red and swollen eyes, and depression associated with dry eyes and visual fatigue.

[0046] Codonopsis, Atractylodes lancea, Phellodendron, Artemisia argyi, Portulaca oleracea, and Herba Cistanches are used as adjuvants. Codonopsis pilosula is sweet and flat in nature and enters the spleen and lung meridians. It has the effects of tonifying the middle qi and replenishing qi, promoting the production of body fluid and nourishing blood. It is combined with Rhizoma Chuanxiong to strengthen the spleen and promote the production of body fluid, regulate the triple energizer, and make the qi and blood flow smoothly. Atractylodes lancea is bitter and slightly cold in nature and enters the liver meridian. It has the effects of clearing the liver and purging fire, improving eyesight and removing cataracts. Phellodendron chinense is bitter and cold in nature and enters the kidney, bladder, and large intestine meridians. It has the effects of clearing heat and dampness, purging fire and detoxifying. Portulaca oleracea is sour and cold in nature and enters the liver meridian. , enters the liver and large intestine meridians, has the effects of clearing away heat and detoxifying, cooling blood and stopping bleeding; the herb is pungent, bitter and warm in nature and flavor and enters the liver and spleen meridians, has the effects of dispelling wind and dampness, promoting blood circulation and relieving pain; the wormwood is pungent, bitter and warm in nature and flavor and enters the liver, spleen and kidney meridians, has the effects of warming the meridians and stopping bleeding, dispelling cold and relieving pain, and can further reconcile the properties of the medicine; all the medicines assist the monarch and minister medicines, regulate the liver and kidney, clear away heat and detoxify, warm the meridians and dispel cold, clear the liver and improve eyesight, dispel wind and stop pain, and make the operation of all the medicines more smooth and enhance the efficacy.

[0047] Safflower, menthol and borneol are the guiding drugs. Safflower is pungent and warm in nature and enters the heart and liver meridians, and has the effects of promoting blood circulation, relieving blood stasis and relieving pain; menthol and borneol are pungent and cool in nature and enter the lung and liver meridians, and have the effects of dispersing wind and heat, opening the orifices and refreshing the mind, and promoting penetration. The three are used as guiding drugs to coordinate and operate the various drugs, guide the drugs upward, and enhance the therapeutic effect of dry eyes and visual fatigue.

[0048] Deep sea whole algae extract is other ingredients. Deep sea whole algae extract has antioxidant effect. Adding it to traditional Chinese medicine external patch can assist transdermal penetration and increase drug penetration.

[0049] The pharmacological effects of the above components are as follows:

[0050] Horsetail: It is sweet and mild in nature, slightly cold, and belongs to the liver and bladder meridians. It has the effects of clearing away heat and promoting diuresis, improving eyesight and removing cataracts, and is mainly used to treat symptoms such as hot stranguria, stranguria with stones, red and swollen eyes, and cataracts. Modern pharmacological studies have confirmed that horsetail has the effect of removing cataracts and improving eyesight, can dispel wind-heat in the liver and gallbladder meridians, and effectively regulate and improve eye abnormalities. In addition, horsetail also has antihypertensive, analgesic, and sedative effects, has an inhibitory effect on the central nervous system, can dilate blood vessels, resist platelet aggregation and thrombosis, has a diuretic effect, and exhibits anti-aging effects.

[0051] Chuanxiong: It is pungent and warm in nature and belongs to the liver, gallbladder and pericardium meridians. It has the effects of promoting blood circulation and qi, dispelling wind and relieving pain. It is used to treat headaches, rheumatic pain, irregular menstruation, postpartum abdominal pain and other symptoms. Modern pharmacological studies have shown that the active ingredients of Chuanxiong, such as ligustrazine and ferulic acid, have the functions of scavenging oxygen free radicals, reducing Ca 2+ It can play a role in multiple systems, multiple organs, and multiple diseases by overloading, protecting vascular endothelial cells, dilating blood vessels, inhibiting cell apoptosis and hypertrophy, regulating immune status, resisting platelet aggregation and thrombosis, and affecting the expression of multiple cytokines.

[0052] Codonopsis: It is sweet and mild in nature and belongs to the spleen and lung meridians. It has the effects of tonifying the middle and replenishing qi, strengthening the spleen and nourishing the stomach, and is used to treat symptoms such as spleen and stomach weakness, poor appetite, loose stools, shortness of breath and fatigue. Modern pharmacological studies have shown that Codonopsis has the effects of regulating gastrointestinal motility, anti-ulcer, anti-hypoxia, and delaying aging; it can increase blood sugar and hemoglobin; it has the effects of tonifying spleen and lung qi, replenishing blood and promoting body fluid. Codonopsis can also enhance the function of the reticuloendothelial system, increase the number of red blood cells, and have a blood-tonifying effect; it has an anti-fatigue effect; it increases the excitability of the central nervous system, improves the vitality of the body, and enhances the body's immunity; codonopsis alkaloids have a significant antihypertensive effect, and increase cardiac output without increasing the blood volume of the brain, lower limbs and internal organs; codonopsis saponins have a regulating effect on the intestines, tonifying the spleen and stomach; promoting coagulation without hemolysis; and increasing blood sugar.

[0053] White chrysanthemum: It is sweet and bitter in nature and cool in taste. It belongs to the lung and liver meridians. It has the effects of dispelling wind and heat, calming the liver and improving eyesight. It is used to treat wind-heat colds, headaches, dizziness, red and swollen eyes and other symptoms. Modern pharmacological studies have shown that white chrysanthemum is rich in flavonoids, polyphenols and volatile oils and other active ingredients, which have significant antioxidant activity. These ingredients can inhibit the production of reactive oxygen species (ROS), increase the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and reduce oxidative damage. White chrysanthemum extract has a protective effect on the retina, can reduce oxidative stress damage, increase the vitality of retinal cells, reduce the apoptosis of retinal ganglion cells and inner and outer nuclear layers, and improve retinal structure and function abnormalities. The water extract or decoction of white chrysanthemum has a certain antibacterial effect on Staphylococcus aureus, various pathogenic bacteria and skin fungi. In addition, preparations of white chrysanthemum have the effects of dilating coronary arteries, increasing coronary blood flow, and improving myocardial oxygen consumption. It also has the effects of lowering blood pressure, shortening coagulation time, and relieving fever, anti-inflammatory, and sedative.

[0054] Safflower: It is pungent and warm in nature and enters the heart and liver meridians. It has the effects of promoting blood circulation, dredge menstruation, dissipating blood stasis and relieving pain. It is used for irregular menstruation, dysmenorrhea, amenorrhea, abdominal pain caused by postpartum blood stasis, traumatic injuries and other symptoms. Modern pharmacological studies have shown that safflower contains a variety of active ingredients, such as flavonoids and volatile oils, which have anti-inflammatory, antioxidant and microcirculation-improving effects. Safflower extract can reduce blood viscosity, prevent thrombosis, and has a certain preventive effect on cardiovascular diseases. In addition, safflower also has a certain effect on regulating blood lipids and blood sugar, and may have a certain auxiliary therapeutic effect on diabetes and its complications.

[0055] Celosia seed: sweet and flat in nature, it enters the liver and kidney meridians. It has the effects of clearing away heat and detoxifying, improving eyesight and removing cataracts. It is used for red, swollen and painful eyes, cataracts, dizziness, tinnitus, hypertension, etc. Modern pharmacological studies have shown that Celosia seed is rich in alkaloids, flavonoids, vitamin A, etc., and has good antioxidant and anti-inflammatory effects. Celosia seed can improve eye blood circulation and has a certain protective effect on retinal diseases. Celosia seed has also been found to have the effect of lowering blood pressure, which is related to the fact that some of its ingredients can dilate blood vessels. In addition, Celosia seed also has certain antibacterial and antiviral effects, and can be used as an auxiliary treatment for some infectious diseases.

[0056] Phellodendron chinense: bitter and cold in nature, belonging to the kidney and bladder meridians. It has the effects of clearing away heat and dampness, purging fire and detoxifying, and is used to treat symptoms such as damp-heat, sores, swelling and toxins, and yellow leucorrhea. Modern pharmacological studies have shown that Phellodendron chinense has antibacterial, antifungal, antitussive, antihypertensive, anti-trichomoniasis, anti-hepatitis, anti-ulcer and immunosuppressive effects.

[0057] Artemisia argyi: It is bitter and warm in nature and belongs to the liver, spleen and kidney meridians. It has the effects of warming the meridians to stop bleeding, dispelling cold and relieving pain, and is used to treat symptoms such as cold-induced bleeding, dysmenorrhea, and metrorrhagia. Modern pharmacological studies have shown that artemisia argyi has an antioxidant effect. The active ingredients in artemisia argyi, such as flavonoids and polyphenol compounds, have strong antioxidant capacity; it has analgesic and anti-inflammatory effects, promotes bile secretion; protects liver cells, and has shown a protective effect on liver cells in experimental studies, and can reduce damage caused by hepatotoxic substances (such as drugs, alcohol, etc.). Artemisia argyi also has hemostatic, antibacterial and antiviral, anti-tumor, blood pressure lowering, blood sugar lowering, asthma relieving, and immune regulation effects.

[0058] Purslane: It is sour and cold in nature and is classified into the liver and large intestine meridians. It has the effects of clearing away heat and detoxifying, cooling blood and stopping bleeding, and is used to treat symptoms such as heat-toxic diarrhea and hemorrhoidal bleeding. Modern pharmacological studies have shown that purslane has antioxidant capacity. The polysaccharide and polyphenol components of purslane can significantly increase the activity of superoxide dismutase in liver tissue and reduce the level of malondialdehyde; it has a liver-protecting effect. Purslane can also be used as a CCl4, C 18 It is an antidote for APAP and high-fat-induced hepatotoxicity, and has a protective effect on hepatocellular carcinoma and liver fibrosis. Purslane also has antibacterial, antiviral, anti-tumor, lipid-lowering, blood sugar-lowering, and anti-aging effects.

[0059] Herba Cistanches: bitter and pungent in nature and flavor, warm in nature, with the effects of relieving the symptoms of malaria, promoting blood circulation and removing blood stasis, and detoxifying. It is used to treat malaria, colds and fever, bronchitis, and injuries from falls; it can be used externally to treat bleeding from trauma, carbuncle, furuncle, and ulcer. Modern pharmacological studies have shown that Herba Cistanches has the effects of clearing away heat and detoxifying, helping to lower body temperature and remove toxins and pathogens from the body; it has the effects of diuresis and dehumidification, promoting the body to eliminate excess water and salt, promoting the production of urine, and helping the body maintain water and electrolyte balance; it can inhibit the production of inflammatory mediators and reduce inflammatory reactions; it can enhance the body's immune function and improve the phagocytic ability of white blood cells.

[0060] Menthol: It is pungent and cool in nature and belongs to the lung and liver meridians. It has the effects of dispersing wind-heat, clearing the head and throat, and clearing rashes. At the same time, it can relieve liver depression and eliminate filth. Menthol has a strong sweating ability, especially good at clearing the head. It is suitable for treating symptoms of wind-heat attacking the surface or attacking the upper part, and can also be used to treat liver depression and heat. Modern pharmacological studies have shown that menthol can protect the central nervous system by acting on members of the transient receptor potential (TRP) channel subfamily M, the 5-hydroxytryptamine system, the γ-aminobutyric acid system, etc.; it can regulate body temperature by regulating temperature sensation and relieving heat stress; it can play an anti-inflammatory role by regulating the production and release of inflammatory mediators such as prostaglandin E2 and leukotriene B4, as well as the cellular immune effect mediated by TRP channels; it can play an analgesic role by activating classical pain targets and enhancing inhibitory synaptic transmission; it can promote transdermal absorption by destroying the stratum corneum; it can play an anti-tumor role by regulating tumor cell proliferation, apoptosis and adhesion pathways. Menthol can be used as a pharmaceutical excipient to correct the flavor of medicines; it can also be used as an active ingredient.

[0061] Borneol: bitter and slightly cold in nature. It has the effects of opening all the orifices, dispersing stagnant heat, removing cataracts and improving eyesight, and relieving swelling and pain. Modern pharmacological studies have shown that borneol can inhibit or kill five common bacteria, including Staphylococcus aureus and beta-lytic streptococci; it has anti-inflammatory effects; anti-fertility effects; analgesic effects; it can promote the transdermal absorption of other drugs; and it promotes the division and growth of glial cells.

[0062] Deep sea algae extract: It has the effects of nourishing yin and moistening dryness, clearing away heat and detoxifying, and anti-oxidation. Modern pharmacological research shows that deep sea algae has antioxidant ability, can remove free radicals in the body, protect cells from oxidative damage, thereby delaying aging and moisturizing; has anti-inflammatory effects, can relieve symptoms such as redness, swelling, and itching; can regulate the immune system and enhance the body's resistance; has antibacterial and antiviral effects; can lower blood lipids; improve intestinal function; and has anti-radiation effects.

[0063] Reference Figure 1 The present invention also provides a method for preparing the above-mentioned Chinese medicine composition for relieving dry eyes and visual fatigue, comprising the following steps:

[0064] S1: Wash and crush Equisetum arvense, Rhizoma Chuanxiong, Codonopsis pilosula, Flos Chrysanthemi, Flos Carthami, Fructus Amaranthus, Phellodendron amurense, Folium Artemisiae Argyi, Herba Portulacae, and Herba Clematidis to obtain a mixed medicinal material, add water to the mixed medicinal material, and perform enzymatic hydrolysis on the mixed medicinal material.

[0065] S2: sterilizing the mixed medicinal materials after enzymatic hydrolysis, and then fermenting them to obtain fermentation liquid.

[0066] S3: The fermentation liquid is inactivated, and then subjected to ultrasonic low-temperature extraction to obtain an extract.

[0067] S4: extracting the extract to obtain an extract.

[0068] S5: The extract is concentrated under reduced pressure, and then menthol, borneol and deep-sea whole algae extract are added and mixed to obtain a Chinese medicine composition.

[0069] Preferably, in step S1, water and enzymes are added to the mixed medicinal materials to perform enzymatic hydrolysis on the mixed medicinal materials. The enzyme in this step can be any one of cellulase, pectinase or neutral protease, or a combination of two or more thereof.

[0070] Cellulose is the main component of plant cell walls. Cellulase can catalyze the hydrolysis of cellulose, breaking it down into smaller molecules, opening the plant cell walls, making it easier to release the effective ingredients in the cells and improving subsequent extraction efficiency.

[0071] Pectin is also an important component of plant cell walls. Pectinase can catalyze the hydrolysis of pectin, breaking it down into smaller molecules, further opening the plant cell walls, making it easier to release the effective ingredients in the cells and improving subsequent extraction efficiency.

[0072] Neutral proteases can catalyze the decomposition of proteins in plant cells, releasing active ingredients bound to proteins and improving subsequent extraction efficiency.

[0073] By using cellulase, pectinase and neutral protease or a combination thereof to enzymatically hydrolyze Chinese medicinal materials, the extraction efficiency of the active ingredients in the medicinal materials can be effectively improved, and the energy consumption and time in the extraction process can be reduced.

[0074] Preferably, in step S2, gamma ray sterilization or high temperature steam sterilization, preferably gamma ray sterilization, can be used to ensure that the liquid medicine is sterile and avoid affecting the subsequent fermentation process. After sterilization, the nutrients can be prepared, and then suitable strains can be selected, including but not limited to lactic acid bacteria, yeasts, or mixtures thereof, for inoculation. The inoculated Chinese medicine mixture is transferred to a fermentation tank, and the temperature, humidity, pH value and other conditions of the fermentation tank are controlled. Stirring can be performed by stirring or shaking, so that the strains are fully in contact with the medicinal materials to promote the fermentation process.

[0075] Preferably, in step S3, the fermentation liquid is inactivated to kill the microorganisms in the fermentation liquid to prevent further fermentation, and then filtered to remove solid residues. The fermentation liquid is then subjected to ultrasonic low-temperature extraction to obtain an extract. Specifically, a container containing the fermentation liquid is placed in an ultrasonic generator, and a high-frequency vibration wave is generated by the ultrasonic generator. The high-frequency vibration wave forms tiny bubbles in the fermentation liquid. These bubbles will collapse rapidly after growing to a certain size, producing a cavitation effect. The cavitation effect helps to break the cell wall structure, so that the effective ingredients in the cell are more fully released. During the entire ultrasonic treatment process, the temperature of the fermentation liquid needs to be maintained at 30-40°C.

[0076] Preferably, in step S4, ethanol is added to the extract to perform an alcohol extraction to obtain an alcohol extract; then water is added to the extract after the alcohol extraction, and water extraction is performed twice in sequence to obtain a first water extract and a second water extract, respectively. The first water extract and the second water extract are mixed to obtain a mixed solution, ethanol is added to the mixed solution to perform alcohol precipitation water extraction, and then the mixture is allowed to stand, and the precipitate is filtered to remove the supernatant to obtain a supernatant. The alcohol extract is mixed with the supernatant to obtain an extract.

[0077] Further preferably, in step S4, the volume concentration of ethanol used in the first alcohol extraction is 60-95%, the volume of ethanol is 3-5 times the volume of the extract, and the processing time of the first alcohol extraction is 1-3h. In the two water extractions, the volume of water is 3-5 times the volume of the extract after the first alcohol extraction, and the processing time of the two water extractions is 1-2h respectively. In the alcohol precipitation water extraction, the volume concentration of ethanol added is 90-95%, the volume concentration of ethanol in the mixed solution after adding ethanol is 60-70%, and the standing time is 20-28h.

[0078] The one alcohol extraction and two water extractions may be pressurized extractions, the pressure may be 0.2-0.3 MPa, and the extraction temperature may be 50-60°C.

[0079] In the present invention, the above-mentioned Chinese medicine composition or the Chinese medicine composition prepared by the above-mentioned preparation method can be used for non-woven eye patches. The preparation method of the non-woven eye patch is: add glycerol, sodium benzoate and deionized water to the Chinese medicine composition, mix them evenly to obtain an eye patch liquid, and immerse the non-woven fabric in the eye patch liquid to obtain a non-woven eye patch. In the eye patch liquid, according to the weight percentage, it includes 0.1-0.3% glycerol, 0.2-0.3% sodium benzoate and 74-75% deionized water, and the balance is the Chinese medicine composition.

[0080] In the present invention, the above-mentioned Chinese medicine composition or the Chinese medicine composition prepared by the above-mentioned preparation method can be used for jelly gel eye patch. The preparation method of jelly gel eye patch is: add glycerin, carbomer, carrageenan and deionized water to the Chinese medicine composition, mix well to obtain jelly gel eye patch.

[0081] The jelly gel eye patch comprises, by weight percentage, 4-5% glycerol, 0.1-0.2% carbomer, 0.01-0.02% carrageenan and 74-75% deionized water, and the remainder is a traditional Chinese medicine composition.

[0082] In the present invention, the above-mentioned Chinese medicine composition or the Chinese medicine composition prepared by the above-mentioned preparation method can be used as a fumigant. The preparation method of the fumigant is: adding sterile water to the Chinese medicine composition, heating, and obtaining a fumigant with a temperature of 40-50° C. wherein the mass ratio of the Chinese medicine composition to the sterile water is 1:40-1:50.

[0083] In the present invention, the Chinese medicine composition or the Chinese medicine composition prepared by the preparation method can be used in eye ointment. The preparation method of the eye ointment is: add medical vaseline, lanolin and liquid wax to the Chinese medicine composition, mix them evenly, and obtain the eye ointment.

[0084] In the present invention, the above Chinese medicine composition or the Chinese medicine composition prepared by the above preparation method can also be used in atomized liquid. The preparation method of atomized liquid is: adding sodium hyaluronate and sodium chloride to the Chinese medicine composition, mixing evenly, and filtering to obtain atomized liquid.

[0085] In order to further clarify the scheme of the present invention and its technical advancement, the following is a description in conjunction with specific embodiments and technical effects.

[0086] Example 1

[0087] The present embodiment provides a traditional Chinese medicine composition, which includes, by weight, 45 parts of horsetail, 35 parts of chuanxiong, 25 parts of codonopsis, 22 parts of white chrysanthemum, 6 parts of safflower, 12 parts of amaranth, 15 parts of phellodendron, 12 parts of wormwood, 4 parts of purslane, 20 parts of scutellaria, 0.5 parts of menthol, 0.5 parts of borneol, and 2 parts of deep-sea whole algae extract.

[0088] Glycerin, sodium benzoate and deionized water were added to the traditional Chinese medicine composition of this embodiment, and the mixture was uniformly mixed to obtain an eye patch solution, and the non-woven fabric was immersed in the eye patch solution to obtain a non-woven fabric eye patch. The eye patch solution includes 0.166% glycerin, 0.265% sodium benzoate and 74.6% deionized water by weight, and the remainder is the traditional Chinese medicine composition.

[0089] Example 2

[0090] The difference between this embodiment and embodiment 1 is that glycerin, carbomer, carrageenan and deionized water are added to the traditional Chinese medicine composition, and the mixture is uniformly mixed to obtain a jelly gel eye patch. The jelly gel eye patch includes 5% glycerin, 0.123% carbomer, 0.0123% carrageenan and 75% deionized water, and the balance is the traditional Chinese medicine composition.

[0091] Example 3

[0092] The present embodiment provides a traditional Chinese medicine composition, which includes, by weight, 40 parts of horsetail, 40 parts of chuanxiong, 15 parts of codonopsis, 25 parts of white chrysanthemum, 5 parts of safflower, 15 parts of amaranth, 20 parts of phellodendron, 5 parts of wormwood, 5 parts of purslane, 15 parts of stinking grass, 1 part of menthol, 0.5 parts of borneol, and 1 part of deep-sea whole algae extract.

[0093] Sterile water was added to the Chinese medicine composition of this example and heated to obtain a fumigant with a temperature of 45° C. The mass ratio of the Chinese medicine composition to sterile water was 1:45.

[0094] Example 4

[0095] The present embodiment provides a traditional Chinese medicine composition, which includes, by weight, 50 parts of horsetail, 30 parts of chuanxiong, 35 parts of codonopsis, 20 parts of white chrysanthemum, 8 parts of safflower, 10 parts of amaranth, 10 parts of phellodendron, 15 parts of wormwood, 3 parts of purslane, 25 parts of scutellaria, 0.5 parts of menthol, 1 part of borneol, and 1 part of deep-sea whole algae extract.

[0096] Add medical vaseline, lanolin and liquid wax to the traditional Chinese medicine composition prepared in this example, mix well, and obtain an eye ointment. The eye ointment includes 20% of the traditional Chinese medicine composition, 60% of the medical vaseline, 10% of the lanolin and 10% of the liquid wax by mass percentage.

[0097] Comparative Example 1

[0098] This comparative example provides a traditional Chinese medicine composition, which is different from Example 1 in that the amount of Stinkgrass in the traditional Chinese medicine composition is 0.

[0099] Test example ①:

[0100] The effects of the Chinese medicine compositions prepared in Examples 1-4 and Comparative Example 1 on dry eye in mice were investigated:

[0101] Six-week-old healthy BALB / c mice were selected, half male and half female. The health standard was: mice with abnormal corneal fluorescence staining and large difference in tear secretion between the two eyes were eliminated through the corneal fluorescence staining score and tear secretion measurement.

[0102] The selected mice were divided into a blank control group, a negative control group, experimental group 1, experimental group 2, experimental group 3, experimental group 4 and experimental group 5. There were 6 mice in each group, and the number of eyes in each group was 12. The number of eyes was averaged when calculating the tear secretion amount below. Among them, the mice in the blank control group were not treated in any way except normal feeding. The eyes of the negative control group and experimental groups 1-5 were dripped with benzalkonium chloride solution with a concentration of 1.5 mg / ml, 3 times a day, for 10 consecutive days.

[0103] After the dry eye model was established, normal saline was dripped into both eyes of mice in the blank control group and the negative control group every day, and equal volumes of eye drops prepared from the Chinese medicine composition prepared in Examples 1-4 and Comparative Example 1 were dripped into both eyes of mice in Experimental Groups 1 to 5. The frequency of administration was 5 times a day for 14 consecutive days.

[0104] The phenol red cotton thread experiment was used to measure the average tear secretion of each group of mice after successful modeling (day 0) and the tear secretion after 14 days of administration. Specifically, the phenol red cotton thread was clamped with ophthalmic forceps and then placed on the outer canthus of the mouse's eye. It was taken out after 60 seconds and the wet length of the phenol red cotton thread (mm) was measured. The specific results are shown in Tables 1 and Figure 2 The tear secretion volume in Table 1 is the average tear secretion volume after modeling, in units of mm, specifically the mean value ± standard deviation. Figure 2 Groups Ⅰ-VII correspond to the average tear secretion of mice in the blank control group, negative control group, experimental group 1, experimental group 2, experimental group 3, experimental group 4 and experimental group 5 after administration for 14 days, respectively, in mm.

[0105] Table 1 Statistics of the average tear secretion of mice in the blank control group, negative control group and experimental groups 1-5

[0106]

[0107] Figure 2-Figure 4 In the table, the same letters (abcd) indicate that there is no statistical difference between the corresponding groups (P>0.05), while different letters indicate that there is a statistical difference between the corresponding groups (P<0.05).

[0108] Table 1 and Figure 2It can be seen that the average tear secretion of mice in the blank control group without modeling and drug administration remained normal. After modeling, the average tear secretion of mice in the negative control group and experimental groups 1 to 5 was significantly reduced, indicating that the modeling was successful. The mice in the negative control group were only dripped with normal saline, and the average tear secretion did not improve. After 14 days of drug administration, the average tear secretion of mice in experimental groups 1 to 4 was greater than 5mm / 1min, returning to normal. Although the average tear secretion of mice in experimental group 5 was improved, it has not yet returned to normal levels.

[0109] Test example ②:

[0110] The effects of the Chinese medicine compositions prepared in Examples 1-4 and Comparative Example 1 on visual fatigue in mice were investigated:

[0111] 1. Animal selection:

[0112] 8-week-old healthy BALB / c mice were selected and kept at 23±2°C and 60-75% relative humidity. The mice were placed in white plastic cages and exposed to normal light from 7 am to 7 pm, with no light at other times, and provided with sufficient food and water.

[0113] 2. Modeling:

[0114] The selected mice were evenly divided into a blank control group, a negative control group, experimental group 1, experimental group 2, experimental group 3, experimental group 4 and experimental group 5. Among them, the mice in the blank control group were not treated in any way except for normal feeding.

[0115] The mice in the negative control group and experimental groups 1-5 were treated as follows:

[0116] The mice were exposed to strong light in a closed dark room without interference from natural light. Each mouse was placed individually in a small square made of acrylic transparent board, and eye drops were applied to the mouse eyeballs before illumination to avoid dehydration of the eyeball surface due to long-term illumination. The illuminator was hung 30 cm from the top of the mouse, and the irradiation was carried out vertically. A thermometer was hung at the same height as the mouse to monitor the temperature in real time to exclude the possibility of photothermal damage to the mouse eyeball caused by temperature increase. Specifically, the mice in the negative control group and the experimental group were irradiated for 2 hours a day for 7 consecutive days at a light intensity of (3000±500)Lux. They ate and drank water normally during the illumination period, and knocked on the cage during the irradiation process to prevent the mice from drowsiness, laziness or lying down, and to keep the mice in a continuous eye state.

[0117] After the asthenopia model was established, physiological saline was dripped into both eyes of mice in the blank control group and the negative control group every day, and equal volumes of eye drops prepared from the Chinese medicine composition prepared in Examples 1-4 and Comparative Example 1 were dripped into both eyes of mice in Experimental Groups 1 to 5. The frequency of administration was: 3 times a day for 4 consecutive weeks.

[0118] At the end of the experiment, the mice were killed, their eyeballs were removed, and the lenses were peeled off from the eyeballs. 9 volumes of normal saline were added, and the mixture was pulped and centrifuged at 4°C. The supernatant was taken and the total antioxidant capacity (T-AOC) in the lenses of the mice in each group was determined using the total antioxidant capacity (T-AOC) detection kit. The results are shown in Figure 3 .

[0119] T-AOC (Total Antioxidant Capacity) refers to the total antioxidant capacity of all antioxidant substances and antioxidant enzymes in an organism, reflecting the overall function of the antioxidant defense system in the body, as well as the comprehensive ability to scavenge free radicals and resist oxidative stress. When the T-AOC content decreases, the body's ability to scavenge free radicals decreases, oxidative stress is more likely to occur, and cells and tissues are more susceptible to damage by free radicals, which may lead to cell apoptosis, inflammatory response and the occurrence of chronic diseases. Figure 3 It can be seen that the T-AOC content of the blank control group and the negative control group was 6.09±0.57nmol / mg and 1.38±0.12nmol / mg, respectively, indicating that excessive light exposure can cause a significant decrease in the T-AOC content in the liver tissue of mice. Compared with the model group, the experimental groups 1 to 4 were able to significantly increase the T-AOC content. Although the experimental group 5 was able to increase the T-AOC content to a certain extent, the degree of increase was not as good as that of the experimental groups 1 to 4.

[0120] In addition, after the mice were killed, the liver tissues removed from the mice were immediately placed in a refrigerator for storage. When preparing liver tissue homogenate, the cryopreserved liver tissues were taken out, and ice-cold physiological saline was added at a material-liquid ratio of 1g:9mL. The liver tissues in the centrifuge tube were ground into tissue homogenates using a grinding rod under low temperature conditions, and then centrifuged in a low-temperature high-speed centrifuge at 4°C and 3000r / min for 10 minutes. The supernatant was taken and the SOD and CAT in the liver tissues of each group of mice were determined using the superoxide dismutase (SOD) kit and the catalase (CAT) kit, respectively. The results are shown in Figure 4 as well as Figure 5 .

[0121] SOD is a metalloenzyme widely found in animals, plants, and microorganisms. It can catalyze the dismutation reaction of superoxide free radicals in organisms, thereby removing O 2-Free radicals, slowing down the oxidative damage caused by oxidative stress. By comparing the blank control group and the negative control group, it can be seen that excessive light exposure can significantly reduce the activity of SOD enzyme in the liver tissue of mice, and the activity of SOD enzyme is reduced from 30.97±4.93nmol·mg in the blank control group to -1 The negative control group had a decrease of 17.54±2.89nmol·mg -1 After administration, the SOD enzyme activity in the liver tissue of mice in Experimental Groups 1 to 4 increased significantly. Although the SOD enzyme activity in the liver tissue of mice in Experimental Group 5 increased, the degree of increase was significantly less than that in Experimental Groups 1 to 4.

[0122] CAT is a catalase that can effectively remove hydrogen peroxide from the body and slow down oxidative damage caused by oxidative stress. By comparing the blank control group and the negative control group, it can be seen that excessive light exposure caused a significant decrease in the activity of CAT enzyme in the liver tissue of mice. The CAT activity decreased from 66.37±6.46nmol·mg in the blank control group to -1 The negative control group had a decrease of 19.35±3.78nmol·mg -1 After administration, the activity of CAT in the liver tissue of mice in Experimental Groups 1 to 4 increased significantly. Although the activity of SOD enzyme in the liver tissue of mice in Experimental Group 5 increased, the degree of increase was obviously much lower than that in Experimental Groups 1 to 4.

[0123] It can be seen from Experimental Example ② that the Chinese medicine composition of the present invention can not only improve dry eye syndrome, but also enhance the antioxidant capacity of mouse lens and liver tissue, and can effectively relieve visual fatigue.

[0124] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or replace some or all of the technical features therein with equivalents. However, these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition for relieving dry eyes and visual fatigue, characterized in that: Calculated by weight, the invention comprises 40-50 parts of horsetail, 30-40 parts of chuanxiong, 15-35 parts of codonopsis, 20-25 parts of white chrysanthemum, 5-8 parts of safflower, 10-15 parts of amaranth, 10-20 parts of phellodendron, 5-15 parts of wormwood, 3-5 parts of purslane, 15-25 parts of stinking grass, 0.5-1 parts of menthol, 0.5-1 parts of borneol and 1-2 parts of deep-sea whole algae extract.

2. The Chinese medicine composition for relieving dry eyes and visual fatigue according to claim 1, characterized in that: Calculated by weight, it includes 45 parts of horsetail, 35 parts of chuanxiong, 25 parts of codonopsis, 22 parts of white chrysanthemum, 6 parts of safflower, 12 parts of amaranth, 15 parts of phellodendron, 12 parts of wormwood, 4 parts of purslane, 20 parts of stinking grass, 0.5 parts of menthol, 0.5 parts of borneol, and 2 parts of deep-sea whole algae extract.

3. A method for preparing the Chinese medicine composition for relieving dry eyes and visual fatigue according to any one of claims 1 to 2, characterized in that: The steps include: S1: Wash and crush Equisetum arvense, Rhizoma Chuanxiong, Codonopsis pilosula, Chrysanthemum officinale, Carthamus tinctorius, Fructus Amaranthus, Phellodendron amurense, Folium Artemisiae Argyi, Portulaca oleracea, and Herba Clematidis to obtain a mixed medicinal material, add water to the mixed medicinal material, and perform enzymatic hydrolysis on the mixed medicinal material; S2: sterilizing the mixed medicinal materials after enzymatic hydrolysis, and then fermenting them to obtain a fermentation liquid; S3: inactivating the fermentation liquid, and then performing ultrasonic low-temperature extraction to obtain an extract; S4: extracting the extract to obtain an extract; S5: The extract is concentrated under reduced pressure, and then menthol, borneol and deep-sea whole algae extract are added and mixed to obtain a Chinese medicine composition.

4. The method for preparing the Chinese medicine composition for relieving dry eyes and visual fatigue according to claim 3, characterized in that: In step S1, water and enzymes are added to the mixed medicinal materials to perform enzymatic hydrolysis on the mixed medicinal materials; the enzyme is cellulase, pectinase or neutral protease.

5. The method for preparing the Chinese medicine composition for relieving dry eyes and visual fatigue according to claim 3, characterized in that: In step S4, ethanol is added to the extract to perform an alcohol extraction to obtain an alcohol extract; then water is added to the extract after the alcohol extraction to perform two water extractions in sequence to obtain a first water extract and a second water extract, respectively; The first water extract and the second water extract are mixed to obtain a mixed solution, ethanol is added to the mixed solution for alcohol precipitation and water extraction, and then the mixed solution is allowed to stand, and the precipitate is removed by filtering to obtain a supernatant; The alcohol extract and the supernatant are mixed to obtain an extract.

6. The method for preparing the Chinese medicine composition for relieving dry eyes and visual fatigue according to claim 3, characterized in that: In step S4, the volume concentration of ethanol used in the first alcohol extraction is 60-95%, the volume of ethanol is 3-5 times the volume of the extract, and the processing time of the first alcohol extraction is 1-3h; In the two water extractions, the volume of water is 3-5 times the volume of the extract after the first alcohol extraction, and the processing time of the two water extractions is 1-2h respectively; In the alcohol precipitation and water extraction, the volume concentration of ethanol added is 90-95%. After the addition of ethanol, the volume concentration of ethanol in the mixed solution is 60-70%, and the standing time is 20-28 hours.

7. Use of the Chinese medicine composition according to any one of claims 1 to 2 or the Chinese medicine composition prepared by the preparation method according to any one of claims 4 to 6 in a non-woven eye patch, characterized in that: Adding glycerin, sodium benzoate and deionized water to the traditional Chinese medicine composition, mixing evenly to obtain an eye patch solution, and immersing a non-woven fabric in the eye patch solution to obtain a non-woven fabric eye patch; The eye patch solution comprises, by weight percentage, 0.1-0.3% of glycerol, 0.2-0.3% of sodium benzoate and 74-75% of deionized water, and the remainder is a traditional Chinese medicine composition.

8. Use of the Chinese medicine composition according to any one of claims 1 to 2 or the Chinese medicine composition prepared by the preparation method according to any one of claims 4 to 6 in jelly gel eye patches, characterized in that: Adding glycerin, carbomer, carrageenan and deionized water to the traditional Chinese medicine composition, and mixing evenly to obtain a jelly gel eye patch; The jelly gel eye patch comprises, by weight percentage, 4-5% of glycerol, 0.1-0.2% of carbomer, 0.01-0.02% of carrageenan and 74-75% of deionized water, and the remainder is a traditional Chinese medicine composition.

9. Use of the Chinese medicine composition according to any one of claims 1 to 2 or the Chinese medicine composition prepared by the preparation method according to any one of claims 4 to 6 in a fumigant, characterized in that: Sterile water is added to the traditional Chinese medicine composition, and the mixture is heated to obtain a fumigant; wherein the mass ratio of the traditional Chinese medicine composition to the sterile water is 1:40-1:

50.

10. Use of the Chinese medicine composition according to any one of claims 1 to 2 or the Chinese medicine composition prepared by the preparation method according to any one of claims 4 to 6 in eye ointment or atomized liquid, characterized in that: The application of the Chinese medicine composition in eye ointment comprises: adding medical vaseline, lanolin and liquid wax to the Chinese medicine composition, mixing evenly, and obtaining the eye ointment; The application of the Chinese medicine composition in the atomized liquid comprises: adding sodium hyaluronate and sodium chloride to the Chinese medicine composition, mixing evenly, and filtering to obtain the atomized liquid.

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