A kind of medical dressing for wound care and preparation method thereof

Abstract

The present invention relates to the technical field of medical dressings, and in particular to a medical dressing for wound care and a preparation method thereof. In terms of mass percentage, the medical dressing comprises the following raw materials: 15-25% gelatin, 1-5% agaricus polypeptide-hydroxyapatite complex, 3-8% modified hydroxypropyl starch, 0.1-0.5% xanthan gum, 0.05-0.1% polyethylene glycol, and the balance water. Agaricus polypeptide-hydroxyapatite complex, modified hydroxypropyl starch and other ingredients are added to the medical dressing formula of the present invention. Agaricus polypeptide-hydroxyapatite complex can effectively shorten the blood coagulation time, thereby accelerating the speed of wound healing; modified hydroxypropyl starch can effectively improve the long-term antibacterial effect of the medical dressing.

Description

Technical Field

[0001] The invention relates to the technical field of medical dressings, and in particular to a medical dressing for wound care and a preparation method thereof. Background Art

[0002] Wound healing is a highly coordinated process involving multiple stages (hemostasis, inflammation, proliferation and remodeling). Medical wound dressings can cover damaged skin and provide a microenvironment conducive to wound healing, playing an important role in wound care and treatment. Currently, most medical dressings still use traditional cotton gauze, which lacks antibacterial properties, and the wound surface is prone to breeding bacteria, which is not conducive to wound healing. Moreover, it needs to be changed frequently and is prone to adhesion to wound tissue, resulting in delayed wound healing.

[0003] Hydrogel materials are widely used in the medical field due to their unique properties, such as high water permeability and excellent biocompatibility. When used as medical wound dressings, hydrogels are soft and elastic, can effectively fit the wound surface, and have good air permeability, can keep the wound surface moist for a long time, and promote wound healing. Despite this, hydrogel dressings still have problems such as poor long-term antibacterial properties and slow wound healing after use. Based on this, it is necessary to improve the dressing composition to improve its performance. Summary of the invention

[0004] In order to overcome the deficiencies of the prior art, one of the objectives of the present invention is to provide a medical dressing for wound care, which can promote wound healing.

[0005] A second object of the present invention is to provide a method for preparing a medical dressing for wound care, which is simple to operate.

[0006] One of the purposes of the present invention is achieved by the following technical solution:

[0007] A medical dressing for wound care comprises the following raw materials, measured by mass percentage: 15-25% gelatin, 1-5% gracilis polypeptide-hydroxyapatite complex, 3-8% modified hydroxypropyl starch, 0.1-0.5% xanthan gum, 0.05-0.1% polyethylene glycol, and the balance water.

[0008] Furthermore, the preparation method of the modified hydroxypropyl starch is as follows:

[0009] The product is prepared by adding hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate into an ethanol aqueous solution, stirring, centrifuging, washing and freeze-drying.

[0010] Furthermore, the mass ratio of the hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate is (10-15):3:2; the volume concentration of the ethanol aqueous solution is 50-60%; the stirring temperature is 60-75°C, and the stirring time is 22-24h.

[0011] Furthermore, the preparation method of the Gracilaria polypeptide-hydroxyapatite complex is as follows:

[0012] The Gracilaria polypeptide is added to a sodium dihydrogen phosphate solution for soaking, and then a calcium chloride solution is added for further soaking. After the soaking is completed, the pH of the reaction solution is adjusted, and the reaction solution is mineralized, and then allowed to stand, washed, and dried to obtain the product.

[0013] Furthermore, the preparation process of the Gracilaria polypeptide is as follows:

[0014] a. Wash the Agaricus lemaneiformis, freeze-dry it at -20°C, and then crush it to obtain the Agaricus lemaneiformis powder; add the Agaricus lemaneiformis powder to a 0.2 mol / L sodium hydroxide solution at a solid-liquid ratio of 1:20, ultrasonicate it at room temperature for 60 minutes, and then centrifuge it at 4°C and 10000 rpm for 15 minutes to obtain a supernatant; adjust the pH of the supernatant to 3 with 0.01 mol / L hydrochloric acid, let it stand for 2 hours, and then centrifuge it at 4°C and 10000 rpm for 15 minutes to obtain a precipitate; re-dissolve the precipitate with ultrapure water, adjust the pH to 7, dialyze it with ultrapure water for 3 days, and then freeze-dry it to obtain the Agaricus lemaneiformis protein;

[0015] b. The agaricus protein of step a was added to water to prepare a 20 mg / mL agaricus protein solution, and the pH was adjusted to 8.0, and trypsin was added at an enzyme-substrate ratio of 4%, and enzymatic hydrolysis was performed at 37 ° C for 6 h, and then the enzyme was inactivated in a 90 ° C water bath for 15 min to obtain agaricus protein hydrolysate;

[0016] c. The enzymatic hydrolysate of the Gracilaria lemaneiformis in step b was passed through a filter having an average molecular weight of 1.5 KDa, and the filtrate was collected and freeze-dried in vacuum at -40°C for 48h to obtain the Gracilaria lemaneiformis polypeptide.

[0017] Furthermore, the dosage ratio of the Gracilaria polypeptide, sodium dihydrogen phosphate solution, and calcium chloride solution is 1 mg: (5-6) mL: (5-6) mL; the concentration of the sodium dihydrogen phosphate solution is 0.2-0.3 mol / L; and the concentration of the calcium chloride solution is 0.3-0.5 mol / L.

[0018] Furthermore, the soaking and continued soaking time are both 20-30 minutes; the pH of the reaction solution is adjusted to 10-11; the mineralization temperature is 50-55° C., and the mineralization time is 7-9 hours.

[0019] The second object of the present invention is achieved by adopting the following technical solution:

[0020] The preparation method of the above-mentioned medical dressing for wound care comprises the following steps:

[0021] (1) Take one-half of the total amount of water, add gelatin and modified hydroxypropyl starch, and after ultrasonication, stir evenly under heat preservation conditions. After cooling, obtain component A, which is set aside;

[0022] (2) taking the remaining water, adding the Gracilaria polypeptide-hydroxyapatite complex, xanthan gum, and polyethylene glycol, stirring evenly to obtain component B, which is set aside;

[0023] (3) Component A of step (1) and component B of step (2) are mixed and stirred evenly, and then sterilized to obtain the product.

[0024] Furthermore, in step (1), the insulation temperature is 55-60° C., the insulation time is 2-4 hours, and the stirring speed is 50-70 rpm.

[0025] Furthermore, the stirring speed in (2) is 50-70 rpm, and the stirring time is 25-35 min; the stirring speed in step (3) is 85-95 rpm, and the stirring time is 20-40 min.

[0026] Furthermore, the sterilization in step (3) is irradiation sterilization.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The medical dressing formula of the present invention contains ingredients such as a Gracilaria polypeptide-hydroxyapatite complex and modified hydroxypropyl starch. The Gracilaria polypeptide-hydroxyapatite complex can effectively shorten the blood coagulation time, thereby accelerating the wound healing speed; and the modified hydroxypropyl starch can effectively improve the long-term antibacterial effect of the medical dressing. DETAILED DESCRIPTION

[0029] The present invention will be further described below in conjunction with specific embodiments. It should be noted that, under the premise of no conflict, the embodiments described below or the technical features can be arbitrarily combined to form new embodiments. The specific conditions not specified in the embodiments are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used, unless otherwise specified, are conventional products obtained through commercial channels.

[0030] The preparation method of the Gracilaria polypeptide in the embodiment of the present invention is as follows:

[0031] a. Wash the Agaricus lemaneiformis, freeze-dry it at -20°C, and then crush it to obtain the Agaricus lemaneiformis powder; add the Agaricus lemaneiformis powder to a 0.2 mol / L sodium hydroxide solution at a solid-liquid ratio of 1:20, ultrasonicate it at room temperature for 60 minutes, and then centrifuge it at 4°C and 10000 rpm for 15 minutes to obtain a supernatant; adjust the pH of the supernatant to 3 with 0.01 mol / L hydrochloric acid, let it stand for 2 hours, and then centrifuge it at 4°C and 10000 rpm for 15 minutes to obtain a precipitate; re-dissolve the precipitate with ultrapure water, adjust the pH to 7, dialyze it with ultrapure water for 3 days, and then freeze-dry it to obtain the Agaricus lemaneiformis protein;

[0032] b. The agaricus protein of step a was added to water to prepare a 20 mg / mL agaricus protein solution, and the pH was adjusted to 8.0, and trypsin (enzyme activity of 250,000 U / g) was added at an enzyme-substrate ratio of 4%, and enzymatic hydrolysis was performed at 37 ° C for 6 h, and then the enzyme was inactivated in a 90 ° C water bath for 15 min to obtain agaricus protein hydrolyzate;

[0033] c. The enzymatic hydrolysate of the Gracilaria lemaneiformis in step b was passed through a filter having an average molecular weight of 1.5 KDa, and the filtrate was collected and freeze-dried in vacuum at -40°C for 48h to obtain the Gracilaria lemaneiformis polypeptide.

[0034] 1. Embodiment

[0035] Example 1

[0036] Example 1 provides a medical dressing for wound care, which is composed of the following raw materials in mass percentage: 20% gelatin, 3% Gracilaria polypeptide-hydroxyapatite complex, 5% modified hydroxypropyl starch, 0.4% xanthan gum, 0.08% polyethylene glycol, and the balance water.

[0037] The preparation method of the above-mentioned Gracilaria polypeptide-hydroxyapatite complex is as follows:

[0038] According to the dosage ratio of 1mg:5.5mL:5.5mL of the Gracilaria polypeptide, sodium dihydrogen phosphate solution and calcium chloride solution, the Gracilaria polypeptide was added to 0.24mol / L sodium dihydrogen phosphate solution and soaked for 25min, and then 0.4mol / L calcium chloride solution was added and soaked for another 25min. After the soaking, the pH of the reaction solution was adjusted to 10.5, and the reaction solution was mineralized at 52°C for 8h, and then allowed to stand at 4°C for 24h, washed and dried to obtain the product.

[0039] The preparation method of the above-mentioned modified hydroxypropyl starch is as follows:

[0040] According to the mass ratio of hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate of 12:3:2, hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate are added to an ethanol aqueous solution with a volume concentration of 52%, stirred at 65°C for 23 hours, and the reaction solution is centrifuged at 4500g for 3 minutes to obtain a precipitate; washed three times with an ethanol aqueous solution with a volume concentration of 52%, and then freeze-dried at -25°C for 36 hours to obtain the product.

[0041] Example 1 also provides a method for preparing the above-mentioned medical dressing for wound care, which is as follows:

[0042] (1) Add gelatin and modified hydroxypropyl starch to half of the total amount of water, perform ultrasonic treatment for 10 min, keep the mixture at 58°C for 3 h under stirring at 60 rpm, cool to room temperature, and obtain component A for later use;

[0043] (2) Add the remaining water to the Gracilaria polypeptide-hydroxyapatite complex, xanthan gum, and polyethylene glycol, and stir at 60 rpm for 30 min to obtain component B for later use;

[0044] (3) Component A of step (1) and component B of step (2) are mixed, stirred at 90 rpm for 30 min, and sterilized by irradiation.

[0045] Example 2

[0046] Example 2 provides a medical dressing for wound care, which is composed of the following raw materials, measured in mass percentage: 25% gelatin, 1% Gracilaria polypeptide-hydroxyapatite complex, 8% modified hydroxypropyl starch, 0.5% xanthan gum, 0.1% polyethylene glycol, and the balance water.

[0047] The preparation method of the above-mentioned Gracilaria polypeptide-hydroxyapatite complex is as follows:

[0048] According to the dosage ratio of 1mg:6mL:6mL of Gracilaria polypeptide, sodium dihydrogen phosphate solution and calcium chloride solution, the Gracilaria polypeptide is added to 0.3mol / L sodium dihydrogen phosphate solution and soaked for 20min, and then 0.5mol / L calcium chloride solution is added and soaked for another 20min. After the soaking, the pH of the reaction solution is adjusted to 11, and the reaction solution is mineralized at 55°C for 7h, and then allowed to stand at 4°C for 24h, washed and dried to obtain the product.

[0049] The preparation method of the above-mentioned modified hydroxypropyl starch is as follows:

[0050] According to the mass ratio of hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate of 15:3:2, hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate are added to an ethanol aqueous solution with a volume concentration of 60%, stirred at 75°C for 22 hours, and the reaction solution is centrifuged at 4500g for 3 minutes to obtain a precipitate; washed three times with an ethanol aqueous solution with a volume concentration of 60%, and then freeze-dried at -25°C for 36 hours to obtain the product.

[0051] Example 2 also provides a method for preparing the above-mentioned medical dressing for wound care, which is as follows:

[0052] (1) Add gelatin and modified hydroxypropyl starch to half of the total amount of water, perform ultrasonic treatment for 10 min, keep the mixture at 60°C for 2 h under stirring at 70 rpm, cool to room temperature, and obtain component A for later use;

[0053] (2) Add the remaining water, silk fibroin-hydroxyapatite complex, Gracilaria lemaneiformis polypeptide, xanthan gum, and polyethylene glycol, and stir at 70 rpm for 25 min to obtain component B for later use;

[0054] (3) Component A of step (1) and component B of step (2) are mixed, stirred at 95 rpm for 20 min, and sterilized by irradiation.

[0055] Example 3

[0056] Example 3 provides a medical dressing for wound care, which is composed of the following raw materials in mass percentage: 15% gelatin, 5% Gracilaria polypeptide-hydroxyapatite complex, 3% modified hydroxypropyl starch, 0.1% xanthan gum, 0.05% polyethylene glycol, and the balance water.

[0057] The preparation method of the above-mentioned Gracilaria polypeptide-hydroxyapatite complex is as follows:

[0058] According to the dosage ratio of 1mg:5mL:5mL of the Gracilaria polypeptide, sodium dihydrogen phosphate solution and calcium chloride solution, the Gracilaria polypeptide was added to 0.2mol / L sodium dihydrogen phosphate solution and soaked for 30min, and then 0.3mol / L calcium chloride solution was added and soaked for 20min. After the soaking, the pH of the reaction solution was adjusted to 10, and the reaction solution was mineralized at 50°C for 9h, and then allowed to stand at 4°C for 24h, washed and dried to obtain the product.

[0059] The preparation method of the above-mentioned modified hydroxypropyl starch is as follows:

[0060] According to the mass ratio of hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate of 10:3:2, hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate are added to an ethanol aqueous solution with a volume concentration of 50%, stirred at 60°C for 24 hours, and the reaction solution is centrifuged at 4500g for 3 minutes to obtain a precipitate; washed three times with an ethanol aqueous solution with a volume concentration of 50%, and then freeze-dried at -25°C for 36 hours to obtain the product.

[0061] Example 3 also provides a method for preparing the above-mentioned medical dressing for wound care, which is as follows:

[0062] (1) Add gelatin and modified hydroxypropyl starch to half of the total amount of water, perform ultrasonic treatment for 10 min, keep the mixture at 55°C for 4 h under stirring at 50 rpm, cool to room temperature, and obtain component A for later use;

[0063] (2) Add the remaining water to the Gracilaria polypeptide-hydroxyapatite complex, xanthan gum, and polyethylene glycol, and stir at 50 rpm for 35 min to obtain component B for later use;

[0064] (3) Component A of step (1) and component B of step (2) are mixed, stirred at 85 rpm for 40 min, and sterilized by irradiation.

[0065] 2. Comparative Example

[0066] Comparative Example 1

[0067] The difference between Comparative Example 1 and Example 1 is that:

[0068] The medical dressing is composed of the following raw materials: 20% gelatin, 3% agaricus polypeptide, 5% modified hydroxypropyl starch, 0.4% xanthan gum, 0.08% polyethylene glycol, and the balance water.

[0069] Comparative Example 2

[0070] The difference between Comparative Example 2 and Example 1 is:

[0071] The medical dressing is composed of the following raw materials: 20% gelatin, 3% hydroxyapatite, 5% modified hydroxypropyl starch, 0.4% xanthan gum, 0.08% polyethylene glycol, and the balance water.

[0072] Comparative Example 3

[0073] The difference between Comparative Example 3 and Example 1 is that the modified hydroxypropyl starch is replaced by a hydroxypropyl starch-zinc acetate dihydrate complex.

[0074] The preparation process of hydroxypropyl starch-zinc acetate dihydrate complex is as follows: according to the mass ratio of hydroxypropyl starch to zinc acetate dihydrate of 12:5, hydroxypropyl starch and zinc acetate dihydrate are added to an ethanol aqueous solution with a volume concentration of 52%, stirred at 65°C for 23 hours, and the reaction solution is centrifuged at 4500g for 3 minutes to obtain a precipitate; washed three times with an ethanol aqueous solution with a volume concentration of 50%, and then freeze-dried at -25°C for 36 hours to obtain a hydroxypropyl starch-zinc acetate dihydrate complex.

[0075] Comparative Example 4

[0076] The difference between Comparative Example 4 and Example 1 is that the modified hydroxypropyl starch is replaced by a hydroxypropyl starch-p-hydroxycinnamic acid complex.

[0077] The preparation process of hydroxypropyl starch-p-hydroxycinnamic acid complex is as follows: according to the mass ratio of hydroxypropyl starch to p-hydroxycinnamic acid of 12:5, hydroxypropyl starch and p-hydroxycinnamic acid are added to an ethanol aqueous solution with a volume concentration of 52%, stirred at 65°C for 23 hours, and the reaction solution is centrifuged at 4500g for 3 minutes to obtain a precipitate; washed three times with an ethanol aqueous solution with a volume concentration of 50%, and then freeze-dried at -25°C for 36 hours to obtain a hydroxypropyl starch-p-hydroxycinnamic acid complex.

[0078] Performance Testing

[0079] The performance of the medical dressings obtained in Examples 1-3 and Comparative Examples 1-4 was tested below. The specific testing process is as follows:

[0080] (1) The wound healing performance of the medical dressings obtained in Examples 1-3 and Comparative Examples 1-4 was tested as follows:

[0081] A total of 70 SD rats with the same growth and health status were selected and randomly divided into 7 groups, with a male-female ratio of 1:1 in each group, respectively recorded as Example 1-3 Group and Comparative Example 1-4 Group. Then each rat was anesthetized by intraperitoneal injection of 30 mg / kg volume fraction of 10% chloral hydrate. After anesthesia, a circular wound with a diameter of 1 cm was created on the back of the rat. Immediately cover the wound with the dressing of the corresponding group, record the time required from the start of covering to the cessation of bleeding, change the medical dressing every 2 days, and record the wound healing status when changing the dressing, and record the time required for complete wound healing. The results are shown in Table 1.

[0082] Table 1

[0083]

[0084] From Table 1, it can be seen that the medical dressings obtained in Examples 1-3 have a more excellent hemostatic effect and an effect of promoting wound healing.

[0085] Compared with Examples 1-3, the blood coagulation time of the medical dressing obtained in Comparative Examples 1-2 is significantly increased, thereby affecting the effect of wound healing. Analysis shows that the medical dressing obtained in Comparative Example 1 uses Gracilaria polypeptide instead of Gracilaria polypeptide-hydroxyapatite complex; the medical dressing obtained in Comparative Example 2 uses hydroxyapatite instead of Gracilaria polypeptide-hydroxyapatite complex. The above results show that the Gracilaria polypeptide-hydroxyapatite complex obtained by the present invention can effectively shorten the blood coagulation time, thereby promoting wound healing.

[0086] (2) The antibacterial properties of the medical dressings obtained in Examples 1-3 and Comparative Examples 1-4 were tested as follows:

[0087] Test bacteria: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa.

[0088] Take 0.5mL of each bacterial solution (concentration is 10 6 CFU / mL), dripped on the medical dressing samples obtained in Examples 1-3 and Comparative Examples 1-4 and the blank group dressing samples (medical dressings without any antibacterial ingredients), covered with coverslips, cultured at 37°C and 95% relative humidity for 24h, taken out and added with 20mL of washing solution respectively, repeatedly washed the samples and coverslips, shaken well, and inoculated in beef extract peptone medium, cultured at 37°C for 24h and 48h respectively, and then counted the viable bacteria. The antibacterial rates of Examples 1-3 and Comparative Examples 3-4 were calculated based on the colony counts of the blank group.

[0089] Table 2

[0090]

[0091] It can be seen from Table 2 that the medical dressings obtained in Examples 1-3 have a more long-lasting antibacterial protective effect.

[0092] Compared with Examples 1-3, the antibacterial effect of the medical dressings obtained in Comparative Examples 3-4 is significantly reduced. It is analyzed that the medical dressing obtained in Comparative Example 3 uses a hydroxypropyl starch-zinc acetate dihydrate complex instead of modified hydroxypropyl starch; the medical dressing obtained in Comparative Example 4 uses a hydroxypropyl starch-p-hydroxycinnamic acid complex instead of modified hydroxypropyl starch. The above results show that the modified hydroxypropyl starch obtained by the present invention can effectively improve the long-term antibacterial effect of the dressing. This is because zinc ions and cinnamic acid can synergistically enhance the antibacterial properties of the dressing, and the two-to-two complexation between hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate enhances the sustained release effect of zinc ions, thereby improving the long-term antibacterial properties of the dressing.

[0093] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and substitutions made by technicians in this field on the basis of the present invention shall fall within the scope of protection required by the present invention.

Claims

1. A medical dressing for wound care, characterized in that: The medical dressing comprises the following raw materials in terms of mass percentage: Gelatin 15-25%, Gracilaria polypeptide-hydroxyapatite complex 1-5%, modified hydroxypropyl starch 3-8%, xanthan gum 0.1-0.5%, polyethylene glycol 0.05-0.1%, and the balance water; The preparation method of the modified hydroxypropyl starch is as follows: Hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate are added to an ethanol aqueous solution, and the mixture is stirred, centrifuged, washed and freeze-dried to obtain the product; The preparation method of the Gracilaria polypeptide-hydroxyapatite complex is as follows: The Gracilaria polypeptide is added to a sodium dihydrogen phosphate solution for soaking, and then a calcium chloride solution is added for further soaking. After the soaking is completed, the pH of the reaction solution is adjusted, and the reaction solution is mineralized, and then allowed to stand, washed, and dried to obtain the product.

2. The medical dressing for wound care according to claim 1, characterized in that: The mass ratio of the hydroxypropyl starch, p-hydroxycinnamic acid and zinc acetate dihydrate is (10-15):3:2; the volume concentration of the ethanol aqueous solution is 50-60%; the stirring temperature is 60-75°C, and the stirring time is 22-24h.

3. The medical dressing for wound care according to claim 1, characterized in that: The dosage ratio of the Gracilaria polypeptide, sodium dihydrogen phosphate solution and calcium chloride solution is 1 mg: (5-6) mL: (5-6) mL; the concentration of the sodium dihydrogen phosphate solution is 0.2-0.3 mol / L; and the concentration of the calcium chloride solution is 0.3-0.5 mol / L.

4. The medical dressing for wound care according to claim 1, characterized in that: The soaking and continued soaking time are both 20-30 minutes; the pH of the reaction solution is adjusted to 10-11; the mineralization temperature is 50-55° C., and the mineralization time is 7-9 hours.

5. The method for preparing the medical dressing for wound care according to claim 1, characterized in that: The following steps are involved: (1) Take one-half of the total amount of water, add gelatin and modified hydroxypropyl starch, and after ultrasonication, stir evenly under heat preservation conditions. After cooling, obtain component A, which is set aside; (2) taking the remaining water, adding the Gracilaria polypeptide-hydroxyapatite complex, xanthan gum, and polyethylene glycol, stirring evenly to obtain component B, which is set aside; (3) Component A of step (1) and component B of step (2) are mixed and stirred evenly, and then sterilized to obtain the product.

6. The method for preparing the medical dressing for wound care according to claim 5, characterized in that: The insulation temperature in step (1) is 55-60° C., and the insulation time is 2-4 hours; the stirring speed is 50-70 rpm.

7. The method for preparing the medical dressing for wound care according to claim 5, characterized in that: The stirring speed in step (2) is 50-70 rpm, and the stirring time is 25-35 min; the stirring speed in step (3) is 85-95 rpm, and the stirring time is 20-40 min.

8. The method for preparing the medical dressing for wound care according to claim 5, characterized in that: The sterilization in step (3) is irradiation sterilization.

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