Sanitary insecticidal compound composition and application thereof

Abstract

The invention belongs to the technical field of sanitary insecticidal, and relates to a sanitary insecticidal compound composition and application thereof. The composition comprises a component A and a component B in a mass ratio of (20: 1)-(1: 10), the component A is a methoxy acrylate compound as shown in a formula I, and the component B is an organophosphorus insecticide. The binary composition provided by the invention solves the problem of resistance of sanitary pests to organophosphorus, improves the control effect, reduces the pesticide application amount, reduces the pesticide application irritation, and prolongs the persistence. The active component A is used as a lethal agent, has no cross resistance with organic phosphorus, has a good lethal effect, has no repellency to sanitary pests, is widely applied to places such as hotels, schools, factories and farms, and has a special effect on prevention and treatment of the sanitary pests.

Description

Technical Field

[0001] The invention belongs to the technical field of sanitary insecticides and relates to a sanitary insecticide compound composition and application thereof. Background Art

[0002] In recent years, the field of residual spraying has seen pain points such as difficulty in completely killing mosquitoes and flies, short or no lasting effect of the pesticide, and other problems. When applying pesticides, the applicators can only increase the dosage and frequency of application, which leads to a significant increase in mosquito and fly resistance, a multiple increase in the cost of application, and an increase in the irritation of the pesticide to the applicators. Therefore, the market is in urgent need of a new generation of residual spraying agents to solve these pain points.

[0003] Flupyroxystrobin is the first methoxyacrylate insecticide, discovered by the British Imperial Chemical Industries and developed by its successor company Syngenta. It is a Qo mitochondrial respiration inhibitor. Flupyroxystrobin has not yet been registered for use in sanitary pests. The compound has the following structural formula:

[0004]

[0005] For a long time, organophosphorus insecticides have been widely used in the prevention and control of public health pests. The long-term use of these agents will inevitably make health pests such as mosquitoes, flies, cockroaches, etc. resistant to some organophosphorus agents. In this way, the control effect of the agents will be greatly reduced. Especially in southern China, the resistance increases rapidly, which greatly reduces the control effect of health pests.

[0006] In response to this dilemma, we considered combining the new piperic acid derivative insecticide compound I-72 with organophosphorus insecticides. On the one hand, the two have different mechanisms of action and there is no cross-resistance when combined, which can solve the problem of resistance of sanitary pests to organophosphorus and reduce the amount of pesticides applied. On the other hand, the compound Flupyroxystrobin has low irritation, which improves the safety of pesticide applicators. Furthermore, through research, it was found that the combination of the two can improve the control effect of sanitary pests, and it is a combined drug application technology with good market prospects.

[0007] In recent years, the field of residual spraying has seen pain points such as difficulty in completely killing mosquitoes and flies, short or no lasting effect of the pesticide, and other problems. When applying pesticides, the applicators can only increase the dosage and frequency of application, which leads to a significant increase in mosquito and fly resistance, a multiple increase in the cost of application, and an increase in the irritation of the pesticide to the applicators. Therefore, the market is in urgent need of a new generation of residual spraying agents to solve these pain points. Summary of the invention

[0008] The technical problem to be solved by the present invention is to provide a sanitary insecticide compound composition and its application in view of the deficiencies in the prior art.

[0009] In order to achieve the above object, the present invention adopts the following technical solution:

[0010] A sanitary insecticide compound composition, comprising component A and component B in a mass ratio of 20:1 to 1:10, wherein component A is a methoxyacrylate compound (Flupyroxystrobin) shown in formula I, and component B is an organophosphorus insecticide;

[0011]

[0012] The component B is any one of dimethoate, fenthion, fenitrothion, and methyl pirimiphos. Preferably, the mass ratio of component A to component B in the composition is 10:1 to 1:2;

[0013] More preferably, the weight ratio of Flupyroxystrobin to Dimethophos is preferably 1:1;

[0014] The weight ratio of Flupyroxystrobin to Fenthion is preferably 2:1;

[0015] The weight ratio of Flupyroxystrobin to Pirimiphos-methyl is preferably 4:1;

[0016] The weight ratio of Flupyroxystrobin to Fenitrothion is preferably 2:1.

[0017] An application of the sanitary insecticide compound composition, and an application of the sanitary insecticide compound composition in preventing and controlling sanitary pests.

[0018] The composition is applied to corresponding areas by topical application; the sanitary pests are one or more of houseflies, city flies, big-headed golden flies, silky green flies, copper green flies, bright green flies, summer toilet flies, toilet flies, red-headed blowflies, and ground flies.

[0019] The topical application method refers to a residual spraying method or a brushing method.

[0020] The application fields include hotels, schools, factories, farms and other places.

[0021] A sanitary insecticide compound preparation comprises active ingredients and auxiliary materials, wherein the active ingredient is the composition and the active ingredient accounts for 2% to 50% of the total weight of the preparation.

[0022] The auxiliary materials are one or more of dispersants, wetting agents, defoamers, antifreeze agents, preservatives, disintegrants, thickeners, binders, food attractants, stabilizers, fillers, and water.

[0023] The preparation is in the form of wettable powder, water dispersible granules or suspension.

[0024] When the dosage form is a wettable powder, it includes the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 5%-10% stabilizer, 5%-15% attractant, and filler is supplemented to 100%.

[0025] When the dosage form is a water-dispersible granule, it includes the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10 disintegrant, 0.1%-1% binder, 5%-10% stabilizer, 5%-15% phagostimulant, and filler to make up to 100%.

[0026] When the dosage form is a suspension, it includes the following materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 0.3%-0.5% preservative, 0.5%-1.5% thickener, 0.1-0.3% defoaming agent, 3%-5% antifreeze agent, 5%-10% stabilizer, 5%-15% attractant, and water is supplemented to 100%.

[0027] The dispersant is selected from: any one of polycarboxylates (for example, TERSPERSE 2500, produced by Huntsman Corporation, USA), lignin sulfonates, alkylbenzene sulfonates, naphthalenesulfonic acid formaldehyde condensate salts, alkylphenol polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene esters, glycerol fatty acid ester polyoxyethylene ethers, or a mixture of two or more of the above in any proportion.

[0028] The wetting agent is selected from: any one of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenylethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (such as TERSPERSE 2425, Huntsman), naphthalene sulfonate (such as NNO), opening powder BX, wetting penetrant F, sodium dodecylbenzene sulfonate, detergent LS, or a mixture of two or more in any proportion.

[0029] The defoaming agent can be any one of polydimethylsiloxane, diethylene glycol ester, tributyl phosphate, and dipalmitoylethylenediamine, or a mixture of two or more of the above in any proportion.

[0030] The antifreeze agent can be any one of ethylene glycol, propylene glycol, glycerol, and urea, or a mixture of two or more of them in any proportion.

[0031] The preservative is selected from potassium sorbate, sodium benzoate, or a mixture of the two in any proportion.

[0032] The disintegrant is selected from any one of ammonium sulfate, sodium sulfate, sodium bicarbonate, and sodium carbonate, or a mixture of two or more of the above in any proportion.

[0033] The thickener is selected from: any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, and magnesium aluminum silicate, or a mixture of two or more of the above in any proportion.

[0034] The binder is selected from: any one of dextrin, polyvinyl pyrrolidone, sodium alginate, or a mixture of two or more of the above in any proportion.

[0035] The attractant is selected from any one of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, and milk flavor, or a mixture of two or more of them in any proportion. After being added to the sanitary composition, the attractant can make the application area 20% to 40% of the conventional application area, and the application position is selected from the four corners of the indoor room wall, the top or bottom corner line.

[0036] The stabilizer is selected from any one of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethyl piperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and a mixture of two or more of them in any proportion. After being added to the sanitary composition, the stabilizer can make the lethality rate on the semi-absorbent surface or the absorbent surface greater than 60% within 30 days.

[0037] The filler is selected from: any one of kaolin, clay, diatomaceous earth, bentonite, white carbon black, attapulgite, corn starch, and light calcium carbonate, or a mixture of two or more of the above in any proportion.

[0038] When the dosage form is a wettable powder, water dispersible granules or suspension, it can be prepared according to conventional methods or existing methods in the art.

[0039] When the sanitary insecticide composition or preparation is used to control sanitary pests, the insecticide composition or preparation is diluted 100-500 times with water and sprayed on the surfaces of walls, floors, doors and windows, ceilings and homes in the application field, so that the sanitary pests are knocked down and killed when they contact the surface.

[0040] Compared with the existing technology, it has the following characteristics:

[0041] (1) The present invention has found through experiments that the combination of Flupyroxystrobin and some organophosphorus insecticides has a synergistic effect. On the one hand, the environmental compatibility is good and the application amount is reduced. On the other hand, from the perspective of the mechanism of action, Flupyroxystrobin and organophosphorus sanitary insecticides have different mechanisms of action and do not have cross-resistance, which solves the problem of sanitary pests' resistance to organophosphorus and improves the control effect. The combination of insecticides with different mechanisms of action can also delay pest resistance, which is beneficial to pest resistance control, and can show good rapid and long-lasting effects on semi-absorbent surfaces or absorbent surfaces.

[0042] (2) Flupyroxystrobin is less irritating, which improves the safety of sprayers. Furthermore, research has found that the combination of the two can improve the control effect of sanitary pests, and is a combination drug application technology with good market prospects.

[0043] (3) In order to solve the problems of persistence and poor lethality to targets such as houseflies, we used formulation technology to solve the problem of persistence. By studying the feeding habits of houseflies and adding attractants, we increased the frequency of licking by houseflies and increased the amount of medicine ingested by the flies. DETAILED DESCRIPTION

[0044] The specific implementation of the technical solution of the present invention is described in detail below, but the present invention is not limited to the following description:

[0045] Application Example 1: Determination of the co-toxicity coefficient of flupyroxystrobin and organophosphorus Test target: housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0046] Test method: Refer to GB / T26350-2010 "Methods for detecting insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of combined effects of mixtures" for test insects;

[0047] Table 1 Determination of the co-toxicity coefficient of Flupyroxystrobin and Dimethoate (for houseflies)

[0048]

[0049]

[0050] As shown in Table 1, when the ratio of Flupyroxystrobin to Dimethoate was 20:1 to 1:10, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 1:1, the synergistic effect was most obvious.

[0051] Table 2 Determination of the co-toxicity coefficient of Flupyroxystrobin and Fenthion (for houseflies)

[0052]

[0053] As shown in Table 2, when the ratio of Flupyroxystrobin to Fenthion was 20:1 to 1:10, the co-toxicity coefficient against houseflies was greater than 120, showing a synergistic effect, especially when the ratio was 2:1, the synergistic effect was most obvious.

[0054] Table 3 Optimal co-toxicity coefficients of Flupyroxystrobin and other organophosphates (for houseflies)

[0055]

[0056] As can be seen from Table 3, the best ratio of Flupyroxystrobin and other organophosphorus compounds is in the range of 10:1 to 1:2, which has a significant synergistic effect.

[0057] The preparation method of the dosage form in each embodiment of the present invention is as follows:

[0058] The laboratory preparation method of wettable powder is: weigh the effective ingredient, wetting agent, dispersant, stabilizer, attractant and filler in proportion, add them into a mixer and mix them evenly, and then grind them with a jet mill to obtain the wettable powder.

[0059] The laboratory preparation method of water-dispersible granules is as follows: weigh the active ingredient, wetting agent, dispersant, attractant, disintegrant, stabilizer and filler in proportion, add them into a mixer and mix them evenly, grind them with a jet mill, use the mixer again, add water and a mixture of a binder, extrude and granulate them with a granulator, and dry them by boiling drying to obtain water-dispersible granules.

[0060] The laboratory preparation method of the suspension concentrate is as follows: weigh water, dispersant, wetting agent, antifreeze, thickener, preservative, attractant, defoaming agent, and stabilizer in proportion, mix them evenly, add the original drug, shear them with a high-speed shearing machine for 5 minutes, and then transfer them to a sand mill for sand grinding for 2-3 hours to control the particle size D90 below 5μm to obtain the suspension concentrate.

[0061] The present invention will be described below in conjunction with specific embodiments:

[0062] Formulation Example 1: 20% Flupyroxystrobin·Dimephos Wettable Powder

[0063] Flupyroxystrobin 10g, dimethoate 10g, sodium dodecylbenzene sulfonate 5g, calcium lignin sulfonate 10g, dimethyl disulfide 15g, urea-formaldehyde resin 5g, kaolin is made up to 100%.

[0064] Preparation Example 2: 30% Flupyroxystrobin·Dimethophos Water Dispersible Granules

[0065] Flupyroxystrobin 20g, dimethoate 10g, pull powder BX0.5g, sodium dodecyl sulfate 0.5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 1g, fatty acid dimethyl disulfide ester 5g, ammonium sulfate 5g, dextrin 0.5g, polyalkylene glycol 5g, kaolin is made up to 100%.

[0066] Preparation Example 3: 15% Flupyroxystrobin·Dimethoate Suspension

[0067] Flupyroxystrobin 5g, dimethoate 10g, alkyl sulfonate calcium salt 0.5g, dodecyl sulfate sodium salt 0.5g, polycarboxylate potassium salt 1g, lignin sulfonate calcium salt 4g, potassium sorbate 0.5g, magnesium aluminum silicate 1g, xanthan gum 0.5g, polydimethylsiloxane 0.3g, propylene glycol 5g, polyacrylic acid 5g, tilapia meal 5g, water is made up to 100%.

[0068] Preparation Example 4: 50% Flupyroxystrobin·Dimethophos Water Dispersible Granules

[0069] Flupyroxystrobin 30g, dimethoate 20g, pull powder BX2g, sodium lauryl sulfate 2g, alkylbenzene sulfonate calcium salt 2g, lignin sulfonate calcium salt 8g, brown sugar 12g, sodium sulfate 3g, ammonium sulfate 1g, polyvinyl pyrrolidone 1g, ethylene oxide-propylene oxide block polyether 6g, kaolin is made up to 100%.

[0070] Preparation Example 5: 2% Flupyroxystrobin·Dimethophos Suspension

[0071] Flupyroxystrobin 1g, dimethoate 1g, sodium lauryl sulfate 0.5g, calcium alkyl sulfonate 0.5g, potassium polycarboxylate 0.5g, sodium naphthalenesulfonic acid formaldehyde condensate 0.5g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, diethylene glycol 0.2g, ethylene glycol 4g, ethyl acrylate 6g, tilapia meal 5g, make up to 100% with water.

[0072] Formulation Example 6: 14% Flupyroxystrobin·Fenthion Wettable Powder

[0073] Flupyroxystrobin 12g, fenthion 2g, sodium lauryl sulfate 2g, calcium lignin sulfonate 6g, brown sugar 10g, white carbon black 10g, vinyl acetate 6g, diatomaceous earth is made up to 100%.

[0074] Preparation Example 7: 22% Flupyroxystrobin·Fenthion Water Dispersible Granules

[0075] Flupyroxystrobin 20g, fenthion 2g, sodium lauryl sulfate 3g, pull open powder BX 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, N-methylacetamide 10g, sodium sulfate 5g, sodium bicarbonate 5g, polyvinylpyrrolidone 0.5g, dextrin 0.5g, tetramethylpiperidinamine 7g, white carbon black 6g, kaolin is made up to 100%.

[0076] Preparation Example 8: 12% Flupyroxystrobin·Fenthion Suspension

[0077] Flupyroxystrobin 10g, fenthion 2g, alkyl sulfonate calcium salt 2g, sodium lauryl sulfate 1g, polycarboxylate potassium salt 4g, lignin sulfonate calcium salt 6g, potassium sorbate 0.5g, xanthan gum 0.5g, tributyl phosphate 0.3g, glycerol 3g, sodium alginate propylene glycol ester 7g, maltose 15g, water is made up to 100%.

[0078] Preparation Example 9: 15% Flupyroxystrobin·Fenthion Suspension

[0079] Flupyroxystrobin 15g, dimethoate 5g, sodium lauryl sulfate 3g, polyoxyethylene fatty acid ester 1.5g, potassium polycarboxylate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, tributyl phosphate 0.2g, dipalmitoyl ethylenediamine 0.1g, ethylene glycol 4g, methyl ethyl sulfonate 8g, honey 6g, water is made up to 100%.

[0080] Formulation Example 10: 18% Flupyroxystrobin·Fenthion Wettable Powder

[0081] Flupyroxystrobin 6g, fenthion 12g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate sodium salt 2g, naphthalenesulfonic acid sodium salt 2g, sodium dodecyl sulfate 1g, fatty acid dimethyl disulfide ester 5g, attapulgite 10g, n-acylated alkyl alcohol amine 7g, light calcium carbonate is supplemented to 100%.

[0082] Formulation Example 11: 50% Flupyroxystrobin·Fenthion Wettable Powder

[0083] Flupyroxystrobin 25g, fenthion 25g, fatty alcohol polyoxyethylene ether 2g, lignin sulfonate calcium salt 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, phenethylphenol polyoxyethylene ether phosphate 2g, dimethyl disulfide 5g, milk flavor 10g, white carbon black 3g, urea-formaldehyde resin 4g, polyalkylene glycol 4g, diatomaceous earth is supplemented to 100%.

[0084] Formulation Example 12: 24% Flupyroxystrobin·Methylpirimiphos wettable powder

[0085] Flupyroxystrobin 16g, methyl pirimiphos 8g, sodium dodecyl sulfate 0.5g, alkylbenzene polyoxyethylene ether phosphate 0.5g, lignin sulfonate calcium salt 6g, anisaldehyde 10g, N-methylacetamide 5g, n-acylated alkyl alcoholamine 9g, clay is supplemented to 100%.

[0086] Formulation Example 13: 40% Flupyroxystrobin·Methylpirimiphos Water Dispersible Granules

[0087] Flupyroxystrobin 30g, methyl pirimiphos 10g, detergent LS 3g, sodium lauryl sulfate 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, lignin sulfonic acid calcium salt 6g, furanone 10g, sodium carbonate 5g, dextrin 1g, sodium alginate propylene glycol 8g, bentonite 20g, corn starch is added to 100%. Formulation Example 14: 50% Flupyroxystrobin·Methyl pirimiphos suspension

[0088] Flupyroxystrobin 40g, methyl pirimiphos 10g, alkyl sulfonate calcium salt 2g, wetting and penetrating agent F2g, glycerol fatty acid ester polyoxyethylene ether 1g, polycarboxylic acid potassium salt 4g, lignin sulfonate calcium salt 4g, sodium benzoate 0.3g, magnesium aluminum silicate 0.2g, carboxymethyl cellulose 0.3g, tributyl phosphate 0.1g, propylene glycol 5g, sodium alginate propylene glycol ester 9g, milk flavor 5g, water is supplemented to 100%.

[0089] Formulation Example 15: 16% Compound·Methyl Pirimiphos Water Dispersible Granules

[0090] Flupyroxystrobin 8g, methyl pirimiphos 8g, pull open powder BX 2g, sodium dodecyl sulfate 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, ligninsulfonate calcium salt 5g, anisaldehyde 10g, sodium sulfate 8g, sodium bicarbonate 2g, polyvinylpyrrolidone 0.3g, sodium alginate 0.5g, sodium alginate propylene glycol 9g, clay 10g, kaolin is made up to 100%.

[0091] Preparation Example 16: 12% Flupyroxystrobin·Methylpirimiphos Suspension

[0092] Flupyroxystrobin 4g, methyl pirimiphos 8g, sodium lauryl sulfate 2g, alkylbenzene polyvinyl ether phosphate 2g, fatty amine polyoxyethylene ether 3g, polycarboxylic acid potassium salt 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, hydroxyethyl cellulose 0.3g, xanthan gum 0.2g, polydimethylsiloxane 0.3g, propylene glycol 4g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol ester 5g, honey 5g, water is made up to 100%.

[0093] Formulation Example 17: 30% Flupyroxystrobin·Methylpirimiphos wettable powder

[0094] Flupyroxystrobin 15g, methyl pirimiphos 15g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, ligninsulfonic acid calcium salt 2g, detergent LS 3g, sodium dodecyl sulfate 1g, N-methylacetamide 12g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol ester 5g, and clay is supplemented to 100%.

[0095] Formulation Example 18: 12% Flupyroxystrobin·Fenpyroxythion Wettable Powder

[0096] Flupyroxystrobin 8g, cypermethrin 4g, sodium lauryl sulfate 2g, detergent LS1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, ligninsulfonic acid calcium salt 5g, N-methylacetamide 8g, furanone 7g, tetramethylpiperidinamine 5g, and clay is supplemented to 100%.

[0097] Formulation Example 19: 30% Flupyroxystrobin·Fenpyroxythion Water Dispersible Granules

[0098] Flupyroxystrobin 25g, cypermethrin 5g, phenethylphenol polyoxyethylene ether phosphate 2g, sodium dodecyl sulfate 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, ligninsulfonic acid calcium salt 5g, dimethyl disulfide 8g, sodium sulfate 3g, sodium alginate 0.5g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol ester 5g, kaolin is made up to 100%.

[0099] Formulation Example 20: 2% Flupyroxystrobin·Methylpirimiphos wettable powder

[0100] Flupyroxystrobin 1g, methyl pirimiphos 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, ligninsulfonic acid calcium salt 2g, detergent LS 3g, sodium dodecyl sulfate 1g, N-methylacetamide 12g, sodium alginate propylene glycol 4g, tetramethylpiperidinamine 4g, clay is supplemented to 100%.

[0101] Formulation Example 21: 16% Flupyroxystrobin·Fenpyrothion Suspension Concentrate

[0102] Flupyroxystrobin 8g, cypermethrin 8g, wetting and penetrating agent F 4g, fatty alcohol polyoxyethylene ether 1g, potassium polycarboxylate 4g, lignin sulfonate calcium salt 4g, sodium benzoate 0.5g, methylcellulose 0.5g, polydimethylsiloxane 0.3g, urea 4g, sodium alginate propylene glycol 5g, N-methylacetamide 5g, water is made up to 100%.

[0103] Formulation Example 22: 45% Flupyroxystrobin·Fenpyroxythion Water Dispersible Granules

[0104] Flupyroxystrobin 30g, cypermethrin 15g, detergent LS 3g, sodium lauryl sulfate 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, lignin sulfonate calcium salt 6g, dimethyl disulfide 5g, sodium sulfate 5g, polyvinyl pyrrolidone 0.1g, sodium alginate propylene glycol ester 5g, kaolin is made up to 100%.

[0105] Formulation Example 23: 18% Flupyroxystrobin·Fenpyroxythion Suspension Concentrate

[0106] Flupyroxystrobin 6g, cypermethrin 12g, sodium lauryl sulfate 2g, potassium polycarboxylate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 2g, potassium sorbate 0.5g, magnesium aluminum silicate 1.2g, xanthan gum 0.3g, diethylene glycol ester 0.3g, propylene glycol 5g, sodium alginate propylene glycol ester 5g, n-acylated alkyl alcohol amine 5g, milk flavor 5g, water is made up to 100%.

[0107] Formulation Example 24: 2% Flupyroxystrobin·Fenthion Water Dispersible Granules

[0108] Flupyroxystrobin 1g, fenthion 1g, sodium dodecyl sulfate 2g, pull open powder BX 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, N-methylacetamide 5g, sodium sulfate 1g, sodium bicarbonate 2g, polyvinylpyrrolidone 0.5g, dextrin 0.5g, n-acylated alkyl alcoholamine 5g, tetramethylpiperidinamine 5g, white carbon black 6g, kaolin is made up to 100%.

[0109] Preparation Example 25: 5% Flupyroxystrobin·Dimethophos Suspension

[0110] Flupyroxystrobin 4g, dimethoate 1g, sodium lauryl sulfate 3g, alkylphenol polyoxyethylene ether 1.5g, potassium polycarboxylate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, diethylene glycol ester 0.2g, ethylene glycol 2g, propylene glycol 3g, sodium alginate propylene glycol 5g, tilapia meal 6g, make up to 100% with water.

[0111] Application Example 2: Indoor efficacy test for controlling mosquitoes and flies

[0112] Test targets: Culex pipiens pallens (a local resistant mosquito species in Yangzhou), female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0113] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0114] Test method: Refer to GB / T 13917.1-2009, forced contact method;

[0115] Test surface: glass board, varnished wood board, gypsum board;

[0116] Dosage setting: The total concentration of active ingredients in the preparation examples is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0117] Control sample 1: 50% dimethoate EC (Jiangsu Gongcheng Biotechnology Co., Ltd.) diluted to 200 mg / L;

[0118] Control sample 2: 500 g / L pirimiphos-methyl emulsifiable concentrate (Syngenta Ltd., UK) diluted to 200 mg / L;

[0119] Test results:

[0120] Table 4: Efficacy test of formulation examples against mosquitoes and flies (glass plate)

[0121]

[0122]

[0123] Table 5: Efficacy test of formulation examples against mosquitoes and flies (varnished wooden board)

[0124]

[0125] Table 6: Efficacy test of formulation examples against mosquitoes and flies (gypsum board)

[0126]

[0127] The test results show that when the dosage is reduced by half, the difference in efficacy between the drugs can be clearly seen on the glass surface. The efficacy of formulation examples 1, 4, 8, 11, 14, 17, and 20 are better than that of control samples 1 and 2 (see Table 4);

[0128] On semi-absorbent surface varnished wood board and absorbent surface gypsum board, the efficacy of the preparation examples decreased, mainly because part of the agent was absorbed by the material, resulting in less surface agent components. However, from the efficacy data, the preparation examples have good persistence, and the efficacy lethality of the varnish surface can reach more than 75% after 30 days, and the efficacy lethality of the gypsum surface can reach more than 60% after 30 days, which is better than the control sample 1 and the control sample 2. (See Table 5 and Table 6).

[0129] Application Example 3: Application of Appetite Inducing Agent in Preparation Example for Drug Efficacy Determination

[0130] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half female and half male;

[0131] Test method: Use a 1.2m*1.2**1.2m glass box, dilute the agent, soak it with 20cm*20cm filter paper, dry it and spread it on the glass box, put 30 houseflies in it, and observe the longest stay time and contact frequency of houseflies on the filter paper surface;

[0132] Test agents: Preparation Example 10, Preparation Example 10 (removal of milk flavor), Preparation Example 20, Preparation Example 20 (removal of N-methylacetamide);

[0133] Dosage setting: The total concentration of active ingredients is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0134] Table 7 Effect of attractants on the efficacy of houseflies

[0135]

[0136] The test results show that the addition of milk flavor to Preparation Example 11 increases the frequency of houseflies contacting the agent, and the efficacy is relatively good; the addition of N-methylacetamide to Preparation Example 20 increases the residence time of houseflies on the filter paper surface, increases the frequency of houseflies licking, and causes the houseflies to ingest more agents, so the final efficacy performance is better (see Table 7).

[0137] Application Example 4: Comparative Test on the Efficacy of Houseflies

[0138] Target: Housefly

[0139] Experimental method: Select the walls of the breeding farm building as the test objects and divide them into areas, spray the pesticide on the wall surface, and record the fly density reduction rate of each treatment group after 1 day, 2 days, and 3 days; the area of ​​the breeding farm room is about 50m2, and the area of ​​each wall is about 20m2.

[0140] Test treatment: Preparation examples 2, 9, 17, and 24 were diluted 100 times and sprayed on the four corners of the wall and the ground, accounting for 40% of the total area, with a dosage of 20 mg active ingredient / m2;

[0141] Control sample 3: Prepared according to the formulation of Preparation Example 2 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0142] Control sample 4: Prepared according to the formulation of Preparation Example 9 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0143] Control sample 5: Prepared according to the formulation of Preparation Example 17 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0144] Control sample 6: Prepared according to the formulation of Preparation Example 24, the attractant component was removed and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0145] When applying the control samples 3, 4, 5, and 6, the pesticide was sprayed on the entire surface of the wall and the ground;

[0146] Table 8 Treatment of Formulation Examples 2, 9, 17, 24

[0147] deal with Application location Application method Formulation Example 2 Four corners of the wall, 20% of the area Residual spraying Preparation Example 9 Four corners of the wall, 40% area Residual spraying Preparation Example 17 Four corners of the wall, 20% of the area Residual spraying Preparation Example 24 Four corners of the wall, 40% area Residual spraying Control sample 1 The whole wall is sprayed Residual spraying Control sample 2 The whole wall is sprayed Residual spraying Control sample 3 The whole wall is sprayed Residual spraying Control sample 4 The whole wall is sprayed Residual spraying

[0148] Test results:

[0149] Table 9 Comparative test of the efficacy of formulation examples 2, 9, 17, and 24 against flies

[0150] deal with 1d density decrease rate 2d density decrease rate 3d density reduction rate Formulation Example 2 67.1％ 85.6％ 95.7％ Preparation Example 9 66.3％ 89.7％ 96.8％ Preparation Example 17 63.9％ 89.3％ 94.2％ Preparation Example 24 65.6％ 90.2％ 98.7％ Control sample 1 58.5％ 79.4％ 86.5％ Control sample 2 53.5％ 79.9％ 83.3％ Control sample 3 52.5％ 78.3％ 85.8％ Control sample 4 56.3％ 80.1％ 86.2％

[0151] As shown in Table 9, the present invention has strong attractant properties by adding attractant components, and converts conventional passive control into active attractant attraction. The application area is 20% and 40% of the conventional application area, and the application location is selected at the four corners of the wall. Formulation examples 2, 9, 17, and 24 have obvious fly control effects, with a 1-day density reduction rate of more than 80%, and a 3-day density reduction rate of more than 94%, which are better than control samples 3, 4, 5, and 6. Formulation examples 2, 9, 17, and 24 add attractant components, and flies are killed after gathering around the attractant components and contacting the liquid medicine; it can be seen that the combined combination of Flupyroxystrobin and organophosphorus insecticide with the addition of attractant components has a better effect on controlling flies than the combined combination of Flupyroxystrobin and organophosphorus insecticide without the addition of attractant components, and the dosage is less than that of the combination without the addition of attractant components.

[0152] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. A sanitary insecticide composite composition, characterized in that: The composition comprises component A and component B in a mass ratio of 20:1 to 1:10, wherein component A is a methoxyacrylate compound represented by formula I, and component B is an organophosphorus insecticide; Formula I.

2. The sanitary insecticide composite composition according to claim 1, characterized in that: The component B is any one of dimethoate, fenthion, fenitrothion and methyl pirimiphos.

3. An application of the sanitary insecticide composite composition according to claim 1, characterized in that: The sanitary insecticide compound composition is used in preventing and controlling sanitary pests.

4. The use of the sanitary insecticide composite composition according to claim 3, characterized in that: The composition is applied to corresponding areas by topical application; the sanitary pests are one or more of houseflies, city flies, big-headed golden flies, silky green flies, copper green flies, bright green flies, summer toilet flies, toilet flies, red-headed blowflies, and ground flies.

5. A sanitary insecticide compound preparation, characterized in that: The preparation comprises active ingredients and auxiliary materials, wherein the active ingredient is the composition according to claim 1, and the active ingredient accounts for 2% to 50% of the total weight of the preparation.

6. The sanitary insecticide compound preparation according to claim 5, characterized in that: The auxiliary materials are one or more of dispersants, wetting agents, defoamers, antifreeze agents, preservatives, disintegrants, thickeners, binders, food attractants, stabilizers, fillers, and water.

7. The sanitary insecticide compound preparation according to claim 5 or 6, characterized in that: The preparation is in the form of wettable powder, water dispersible granules or suspension.

8. The sanitary insecticide compound preparation according to claim 6, characterized in that: The attractant is selected from one or more of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, and milk flavor.

9. The sanitary insecticide compound preparation according to claim 6, characterized in that: The stabilizer is selected from one or more of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethyl piperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and n-acylated alkyl alcohol amine.

Images