Intraoral photographing aid

Abstract

Provided is an intraoral imaging aid which is inserted into an oral cavity for imaging the oral cavity, and which is provided with: a cylindrical main body; the main body includes a first end portion having an opening into which an image pickup apparatus can be inserted, a second end portion located on a side opposite to the first end portion and providing a field of view from an inner side of the main body to an outer side of the main body, and an inner circumferential surface extending from the first end portion to the second end portion and allowing sliding of the image pickup apparatus, one end of the pressing piece is connected with the main body, and the other end of the pressing piece is located closer to the outer side than the second end part and is formed in a manner of extending in the length direction of the main body.

Description

[0001] This application is a divisional application of the Chinese patent application whose original application was filed on June 30, 2020, with application number 202080061421.9 and invention name “Pharmaceutical Composition for Treating Influenza Virus Infection”. Technical Field

[0002] The present invention relates to a pharmaceutical composition for treating influenza virus infection. Alternatively, the present invention relates to a method for treating and preventing influenza virus infection containing an anti-influenza virus agent as an active ingredient, and use of the active ingredient for producing an anti-influenza virus agent for treating and preventing influenza virus infection. Background Art

[0003] Non-patent document 1 reports that lymphoid follicles appearing in the deepest part of the pharynx have a pattern unique to influenza virus infection. Lymphoid follicles with such a pattern are called influenza follicles. Influenza follicles are a characteristic sign of influenza and appear about 2 hours after the onset of the disease.

[0004] Prior art literature

[0005] Non-patent literature

[0006] Non-patent document 1: Miyamoto / Watanabe, "Study on the significance and value of pharyngeal examination results (influenza follicles)", NIH Medical Journal 72(1):11-18 (2013) Summary of the invention

[0007] Problems to be solved by the invention

[0008] It is expected that accurate identification of influenza follicles will lead to a leap in diagnostic accuracy. However, proper identification of influenza follicles requires intensive training to understand a large number of cases, which is not easy for general doctors. Unfortunately, the above research results are only effectively used by a limited range of doctors. Therefore, there is room for improvement in the treatment efficiency of influenza virus infections.

[0009] Therefore, an object of the present invention is to improve the therapeutic efficiency of influenza virus infection.

[0010] Methods for solving problems

[0011] In order to solve the above-mentioned problems, the first aspect of the present invention provides a pharmaceutical composition for treating influenza virus infection, characterized in that it is a pharmaceutical composition for treating influenza virus infection containing an anti-influenza virus agent as an active ingredient,

[0012] An anti-influenza virus agent is administered to a patient who is determined to be positive for influenza virus infection by an intraoral image captured using an intraoral imaging device.

[0013] In the pharmaceutical composition for treating influenza virus infection according to the first aspect of the present invention having the above-mentioned structure,

[0014] The intraoral photography device may include:

[0015] Camera equipment for obtaining images of the interior of the mouth;

[0016] a light source for irradiating light to a subject of the imaging device;

[0017] a storage device storing an algorithm for determining influenza virus infection; and

[0018] computing device,

[0019] The computing device can execute:

[0020] Determination processing, based on the image and the algorithm, determining the possibility of the influenza virus infection; and

[0021] Output processing, outputting the result of the above-mentioned determination processing.

[0022] Furthermore, in the pharmaceutical composition for treating influenza virus infection according to the first aspect of the present invention having the above-mentioned configuration, it may be:

[0023] The above-mentioned camera device obtains an image of the pharynx,

[0024] The determination process includes determining whether the pattern specific to the influenza virus infection appears in the pharynx.

[0025] Furthermore, in the pharmaceutical composition for treating influenza virus infection according to the first aspect of the present invention having the above-mentioned configuration,

[0026] The anti-influenza virus agent may be selected from baloxavir, oseltamivir, zanamivir, peramivir and laninamivir, but is not limited thereto.

[0027] In addition, a second aspect of the present invention provides a pharmaceutical composition for preventing influenza virus infection, characterized in that it is a pharmaceutical composition for preventing influenza virus infection containing an anti-influenza virus agent as an active ingredient,

[0028] An anti-influenza virus agent is administered to a close contact of a patient who is determined to be positive for influenza virus infection by an intraoral image captured by an intraoral imaging device.

[0029] Here, close contacts refer to, for example, people who have moved together with or come into contact with a patient suspected of influenza virus infection, or who have sat in adjacent seats on an airplane or at a workplace, etc., including family members living together and people living together.

[0030] Furthermore, in the pharmaceutical composition for treating influenza virus infection according to the second aspect of the present invention having the above-mentioned configuration,

[0031] The above-mentioned close contacts may be elderly people over 65 years old, patients with chronic respiratory diseases or chronic heart diseases, patients with metabolic diseases including diabetes, or patients with renal dysfunction who may become high-risk patients if infected with the influenza virus.

[0032] Furthermore, in the pharmaceutical composition for treating influenza virus infection according to the second aspect of the present invention having the above-mentioned configuration, it may be:

[0033] The intraoral photography device includes:

[0034] Camera equipment for obtaining images of the interior of the mouth;

[0035] a light source for irradiating light to a subject of the imaging device;

[0036] a storage device storing an algorithm for determining influenza virus infection; and

[0037] computing device,

[0038] The above computing device executes:

[0039] Determination processing, based on the image and the algorithm, determining the possibility of the influenza virus infection; and

[0040] Output processing, outputting the result of the above-mentioned determination processing.

[0041] Furthermore, in the pharmaceutical composition for treating influenza virus infection according to the second aspect of the present invention having the above-mentioned configuration, it may be:

[0042] The above-mentioned camera device obtains an image of the pharynx,

[0043] The determination process includes determining whether the pattern specific to the influenza virus infection appears in the pharynx.

[0044] In addition, a third aspect of the present invention provides a pharmaceutical composition for preventing influenza virus infection, characterized in that it is a pharmaceutical composition for preventing influenza virus infection containing an anti-influenza virus agent as an active ingredient,

[0045] Anti-influenza virus agents are administered to close contacts of the patient, including patients who have developed influenza infection symptoms and persons whose intraoral images taken using an intraoral imaging device have been determined to be negative for influenza virus infection.

[0046] In the pharmaceutical composition for treating influenza virus infection according to the third aspect of the present invention having the above-mentioned structure,

[0047] The above-mentioned persons may be elderly persons over 65 years old, patients with chronic respiratory diseases or chronic heart diseases, patients with metabolic diseases including diabetes, or patients with renal dysfunction.

[0048] Furthermore, in the pharmaceutical composition for treating influenza virus infection according to the third aspect of the present invention having the above-mentioned configuration, it may be:

[0049] The intraoral photography device includes:

[0050] Camera equipment for obtaining images of the interior of the mouth;

[0051] a light source for irradiating light to a subject of the imaging device;

[0052] a storage device storing an algorithm for determining influenza virus infection; and

[0053] computing device,

[0054] The above computing device executes:

[0055] Determination processing, based on the image and the algorithm, determining the possibility of the influenza virus infection; and

[0056] Output processing, outputting the result of the above-mentioned determination processing.

[0057] Furthermore, in the pharmaceutical composition for treating influenza virus infection according to the third aspect of the present invention having the above-mentioned configuration, it may be:

[0058] The above-mentioned camera device obtains an image of the pharynx,

[0059] The determination process includes determining whether the pattern specific to the influenza virus infection appears in the pharynx.

[0060] Effects of the Invention

[0061] According to the present invention, the therapeutic efficiency of influenza virus infection can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0062] Figure 1 It is a schematic diagram of a medical device 1 including an intraoral imaging device 5 and an intraoral imaging auxiliary tool 3 according to a typical embodiment of the present invention.

[0063] Figure 2 To express Figure 1 A stereoscopic image of the intraoral photography auxiliary device 3.

[0064] Figure 3 for Figure 2 A longitudinal cross-sectional view of the intraoral photography auxiliary device 3.

[0065] Figure 4 To express that Figure 2 FIG. 7 is a diagram showing an example of a state in which the intraoral imaging auxiliary tool 3 is inserted into the oral cavity 71 .

[0066] Figure 5 It is a perspective view showing the intraoral imaging auxiliary tool 13 according to the first modification.

[0067] Figure 6 To express Figure 5 A longitudinal cross-sectional view of the intraoral photography auxiliary device 13.

[0068] Figure 7 To express that Figure 5 FIG. 7 is a diagram showing an example of a state in which the intraoral imaging auxiliary tool 13 is inserted into the oral cavity 71 .

[0069] Figure 8 It is a perspective view showing an intraoral imaging assisting tool 23 according to Modification Example 2.

[0070] Fig. 9 This is a perspective view of the intraoral imaging assisting tool 43 according to Modification 3.

[0071] Fig.10 for Fig. 9 A cross-sectional view of the intraoral photography aid 43.

[0072] Fig.11 This is a perspective view of an intraoral imaging assisting tool 530 according to Modification 4.

[0073] Fig.12 for Fig.11 A side view of the intraoral photography aid 530.

[0074] Fig.13 This is a perspective view of the intraoral imaging assisting tool 630 according to the fifth modification.

[0075] Fig.14 for Fig.13 A side view of the intraoral photography aid 630.

[0076] Fig.15 For Fig.13 A stereoscopic image of the intraoral photography assisting device 630 as viewed from the bottom side.

[0077] Fig.16 It is a schematic diagram showing the packaged intraoral imaging auxiliary tool 3.

[0078] Fig.17 To express Figure 1 A diagram showing an example of the appearance of the intraoral imaging device 5.

[0079] Fig.18 To express Fig. 9 A block diagram of an example of the hardware configuration of the intraoral imaging device 5.

[0080] Fig.19 To express Fig. 9 A block diagram of an example of the functional structure of the intraoral imaging device 5.

[0081] Fig. 20 To express Fig. 9 Flowchart of operation example 1 of the intraoral photography device 5.

[0082] Fig.21 To express Fig. 9 Flowchart of action example 2 of the intraoral photography device 5.

[0083] Fig. 22 Flowchart showing the steps of generating the judgment algorithm.

[0084] Fig.23 This is a flowchart showing an example of an image extraction procedure.

[0085] Fig.24 To express Fig. 9 Flowchart of operation example 3 of the intraoral photography device 5.

[0086] Fig.25 It is a flowchart showing an example of the imaging operation of the intraoral imaging device 5 .

[0087] Fig.26 This is a flowchart showing an example of the steps from oral imaging to administration of an anti-influenza virus agent.

[0088] Fig. 27 This is a schematic diagram of the cross-sectional shape of the head of a person 7 .

[0089] Fig.28 This is a schematic diagram of the oral cavity 71. DETAILED DESCRIPTION

[0090] Below, while referring to the attached Figure 1 The representative embodiments of the present invention are described in detail. However, the present invention is not limited to such embodiments and drawings. In addition, the drawings are used to conceptually illustrate the present invention, so in order to facilitate understanding, the dimensions, ratios or numbers are sometimes exaggerated or simplified as needed. In addition, in the following disclosure, influenza virus infection is sometimes abbreviated as "influenza". In addition, the range "X to Y" shown in this specification means "above X and below Y".

[0091] In this embodiment, it is envisioned that a medical device including an intraoral photography device is used for the determination of influenza, and an anti-influenza virus agent is administered to a patient who is determined to be positive for influenza virus infection and his / her cohabiting family members or cohabitants. Here, an intraoral photography auxiliary device is used to photograph the inside of the mouth (especially the pharynx), but the present invention is not limited to this. In addition, the intraoral photography auxiliary device can be used in combination with other devices such as smart phones and tablet terminals.

[0092] Hereinafter, the intraoral imaging auxiliary tool and the intraoral imaging device included in the medical device will be described, and then the steps until the anti-influenza virus agent is administered will be described.

[0093] 1Overview of Medical Devices

[0094] Reference Figure 1 , an overview of the medical device 1 of the present embodiment is described. As shown in the figure, the medical device 1 includes an intraoral imaging device 5 and an intraoral imaging auxiliary tool 3. The intraoral imaging device 5 is suitable for use in combination with the intraoral imaging auxiliary tool 3, but can also be used alone or in combination with other auxiliary tools.

[0095] The intraoral photography device 5 includes a camera device 57 for acquiring an image of a subject, and dedicated software is pre-installed in the device 5. A user (e.g., a doctor) causes a subject 7 (e.g., a patient) suspected of having influenza to bite the intraoral photography auxiliary device 3 to ensure a field of view for photography. Then, the user inserts the camera device 57 into the intraoral photography auxiliary device 3 to photograph the pharynx 72 of the subject 7. In addition, the user can also photograph the oral cavity 71 of the subject 7 by adjusting the insertion depth and insertion angle of the intraoral photography auxiliary device 3. Alternatively, the user can insert the intraoral photography auxiliary device 3 with the camera device 57 stored inside into the mouth of the subject 7, or can cause the subject 7 to insert the intraoral photography auxiliary device 3 into the mouth.

[0096] The captured image is processed by a pre-generated judgment algorithm. It is envisioned that the processing is performed using the intraoral camera 5, but it can be performed using other computers. For example, the judgment algorithm detects pharyngeal symptoms (patterns) inherent to influenza, such as influenza follicles, and indicates the possibility of influenza. As a result, even doctors with little experience or interns can accurately and early diagnose influenza. In addition, experienced doctors can also obtain useful judgment data. Furthermore, by improving the correct diagnosis rate of influenza, patients can complete medical treatment with a single visit and receive appropriate treatment from an earlier stage.

[0097] 2-1 Intraoral photography aids

[0098] Reference Figure 2-Figure 4 , the intraoral photography assisting device 3 of this embodiment is described in detail.

[0099] The intraoral photography auxiliary tool 3 is an auxiliary tool for photographing the inside of the mouth (the inside of the oral cavity 71 and the pharynx 72) of a person (the determination subject) 7. More specifically, the intraoral photography auxiliary tool 3 is inserted into the oral cavity 71 during intraoral photography, and is used to obtain a good field of view of the photographing area including the inside of the oral cavity 71 or the pharynx 72. Further, from the perspective of obtaining a good field of view, the intraoral photography auxiliary tool 3 is preferably light-transmissive. In the present embodiment, a mouthpiece is envisioned as an example of the intraoral photography auxiliary tool 3, but it is not limited to this.

[0100] like Figure 2 As shown, the intraoral photography auxiliary tool 3 includes a main body 31, an edge portion 34, and a limiting portion 35. The intraoral photography auxiliary tool 3 only needs to have the main body 31, and may not have both or one of the edge portion 34 and the limiting portion 35. In this embodiment, the intraoral photography auxiliary tool 3 is assumed to be an integrally molded resin product, but the intraoral photography auxiliary tool 3 can also be made of other raw materials such as paper, cloth, elastic rubber or metal, or can be made of multiple raw materials. In addition, the intraoral photography auxiliary tool 3 is assumed to be a disposable type, but it can also be a reusable type.

[0101] The main body 31 is cylindrical in shape. When the main body 31 is inserted deeply into the oral cavity 71, for example, Figure 1 and Fig. 27 As can be seen from the comparison, the tongue 73 is pushed downward and the soft palate 74 is pushed upward. That is, the intraoral photography auxiliary device 3 can also be said to be a tongue depressor. Figure 4 and Fig.28 As can be seen from the comparison, it is possible to capture the inner side of the auxiliary tool 3 (main body 31) from the mouth to ensure a good view of the pharynx 72.

[0102] In this embodiment, the main body 31 extends substantially in a straight line. That is, the inner diameter and outer diameter of the main body 31 are substantially constant in the entire length direction. However, the main body 31 may be partially or entirely bent, and the inner diameter or outer diameter of the main body 31 may also be changed, as long as it does not hinder the sliding of the camera device 57 on its inner circumference.

[0103] The cross-sectional shape of the main body 31 is assumed to be a perfect circle. However, the cross-sectional shape may be an ellipse, a polygonal cross-section such as a quadrilateral, or an asymmetric shape such as a roughly D-shaped cross-sectional shape. When the main body 31 has an elliptical, polygonal, or asymmetric cross-sectional shape, when the camera device 57 corresponding to the shape of the main body 31 slides in the main body 31, it is possible to limit or inhibit the movement (i.e., rotation) in the circumferential direction centered on the axial direction of the main body 31, thereby being able to obtain an intraoral image suitable for determination and having a consistent orientation.

[0104] In the case where the main body 31 has a perfect circular cross-sectional shape, as shown in FIG. Figure 6 As described later, the rotation of the imaging device 57 in the main body 31 can be restricted by providing a guide rail and a protrusion that engage with each other on the outer surface of the imaging device 57 and the inner peripheral surface of the main body 31 .

[0105] like Figure 3 As shown, the main body 31 includes ends 32 and 33 located on opposite sides. When the intraoral photography auxiliary tool 3 is installed in the oral cavity 71 , the end 32 is exposed to the outside, and the end 33 is located in the oral cavity 71 .

[0106] The outer peripheral surface of the main body 31 is smooth, and the main body 31 and the end portion 33 are connected to each other smoothly and continuously and integrally via the connection surface 36. That is, the outer surface of the main body 31 is processed to be smooth so as not to damage the oral cavity 71.

[0107] The body 31 may have a scale 37. The scale 37 is arranged along the length direction of the body 31 and serves as a standard for how deeply the body 31 is inserted into the oral cavity 71. The scale 37 may be provided on either the outer circumferential surface or the inner circumferential surface of the body 31. In the case where the scale 37 is provided on the outer circumferential surface, as in Figure 2 As shown, it is preferably set on the side that contacts the upper lip and the upper front teeth 75, that is, the upper side. The scale 37 is preferably configured at a predetermined interval (for example, every 1 cm). Figure 2 The scale 37 shown has a length of nearly half the circumference of the main body 31 in the circumferential direction, but is not limited to this and may be shorter or longer.

[0108] In this embodiment, as an example of the scale 37, a plurality of raised portions arranged along the length direction of the main body 31 are envisioned. The surface of the raised portion is preferably processed to be smooth in a manner not to damage the oral cavity of the determination subject 7. However, the scale 37 may be, for example, a substantially linear convex portion extending in the length direction of the outer peripheral surface of the main body 31, or may be printed or displayed on the outer peripheral surface or the inner peripheral surface of the main body 31.

[0109] like Figure 3 As shown, the end portion 32 has an opening 32A, and the opening 32A can insert the imaging device 57. Therefore, the imaging device 57 is inserted into the main body 31 through the opening 32A, and is taken out of the main body 31 through the opening 32A.

[0110] The edge portion 34 may be provided at the end portion 32. The edge portion 34 extends from the end portion 32 toward the radially outer side of the main body 31. When the main body 31 enters deep into the oral cavity 71, the edge portion 34 contacts the lips or front teeth of the determination subject 7 to prevent the determination subject 7 from swallowing the intraoral photography auxiliary device 3 by mistake. That is, the edge portion 34 functions as a stopper.

[0111] In this embodiment, the edge 34 is provided along the entire circumference of the end portion 32, and for example, it can be partially formed at a portion corresponding to the upper lip and the lower lip in the end portion 32. In addition, the outer edge of the edge 34 can be as follows: Figure 2 It may be a perfect circle, an ellipse, or a polygonal shape such as a quadrilateral.

[0112] For example, when the determination subject 7 coughs, the droplets from the mouth of the determination subject 7 hit the edge 34. That is, the edge 34 also helps the doctor to avoid the droplets from the determination subject 7. In order to have this droplet avoidance function, for example, the shape and size of the edge 34 can be appropriately selected according to the user's age, physique, etc.

[0113] The end portion 33 may also be opened to form a window portion 33A. The window portion 33A is used to provide a field of view from the inside of the main body 31 to the outside of the main body 31, and here, the lens of the camera device 57 in the main body 31 is exposed to the outside. However, the window portion 33A may also be covered by, for example, a transparent member, which may be integrally formed with the main body 31 or may be formed separately from the main body 31. In order to prevent fogging due to the oral temperature of the subject 7 or his / her breathing, the member covering the window portion 33A is preferably a member that has been subjected to anti-fog processing and measures or is made of raw materials that are not easy to fog. As anti-fog processing and measures, there are methods of applying anti-fog coating to the member covering the window portion 33A, and using electric heating wires or other heat sources to increase the temperature of the member covering the window portion 33A, but it is not limited to this.

[0114] The end portion 33 protrudes toward the inside of the main body 31, forming a limiting portion 35. The limiting portion 35 contacts the camera device 57 in the main body 31 and is provided to limit the camera device 57 from passing through the end portion 33. However, the limiting portion 35 may not be provided at the end portion 33. For example, Figure 6 The guide portion 141 (recess or groove) described in the relationship contacts the engaging protrusion 57A of the camera device 57 at its terminal end, thereby restricting the movement of the camera device 57 to the deep side, and therefore also plays the role of the restriction portion 35.

[0115] When the intraoral photography auxiliary device 3 is used to photograph the pharynx 72, as shown in FIG. Figure 1 As shown, the user inserts the intraoral photography aid 3 into the oral cavity 71 of the determination subject 7. At this time, the main body 31 pushes the tongue 73 downward and pushes the soft palate 74 upward. Then or at the same time, the user inserts the camera 57 into the main body 31. At this time, as shown in FIG. Figure 4 As shown, the tongue 73 and the soft palate 74 do not enter the field of view of the camera 57, or even if they enter, they only occupy a very small range. Therefore, a good field of view of the pharynx 72 can be obtained.

[0116] Furthermore, the edge portion 34 can prevent the subject 7 from swallowing the intraoral imaging aid 3. At the same time, the edge portion 34 can suppress the splashing of droplets from the mouth of the subject 7 to the user, reducing the risk of secondary infection of the user with infectious diseases such as influenza.

[0117] Furthermore, the scale 37 enables the intraoral photography auxiliary tool 3 to be arranged at an appropriate depth in the oral cavity according to the physique and the photography part of the determination subject 7. This facilitates the photography of a clear image of the target part and can suppress the discomfort and swallowing of the determination subject 7 caused by inserting the main body 31 too deeply unnecessarily.

[0118] 2-2 Modification 1 of the Intraoral Photography Auxiliary Device

[0119] Reference Figure 5-Figure 7 , an intraoral photography assisting tool 13 according to a first modification of the present embodiment will be described.

[0120] The intraoral photography auxiliary tool 13 has the same components as the above-mentioned intraoral photography auxiliary tool 3, and further includes a substantially linear guide portion 141. On the other hand, the imaging device 57 includes an engagement protrusion 57A that engages with the guide portion 141. Therefore, the guide portion 141 can slide in the main body 131 without rotating the imaging device 57 relative to the main body 131.

[0121] In variation 1, if Figure 6 As shown, an example of guide portion 141 is a groove extending substantially linearly from end 132 toward end 133 so as to correspond to engagement protrusion 57A on the outer peripheral surface of imaging device 57. Alternatively, guide portion 141 may be a pair of guide rails protruding from the inner peripheral surface of the body.

[0122] Optionally, the cross-sectional shape of the main body 131 is an elliptical shape, a polygonal shape, or an asymmetric shape such as a roughly D-shape, and when the camera device 57 has an outer shape corresponding to the cross-sectional shape of the main body 131, the camera device 57 can slide within the main body 131 without rotating relative to the main body 131, so that the inner circumferential surface of the main body 131 in this case also acts as a guide portion.

[0123] like Figure 5 As shown, an indication display 142 is provided on the outer surface of the main body 131 and the edge portion 134, and the indication display 142 is used to facilitate the positioning of the main body 131 relative to the lips of the determination subject 7. Figure 7As shown, the indication display 142 is preferably arranged at the center of the upper lip of the determination subject 7 or at a position corresponding to the upper front teeth 75, that is, the center of the upper part. For example, the user installs the intraoral photography auxiliary tool 3 in the oral cavity 71 in a state where the indication display 142 is aligned with the center of the upper lip of the determination subject 7, thereby aligning the direction of the image captured by the camera 57 in almost the same direction. As a result, machine learning using images and determination processing of specific diseases (such as influenza) become easy.

[0124] 2-3 Modification 2 of the Intraoral Photography Auxiliary Device

[0125] Reference Figure 8 , an intraoral photography assisting tool 23 according to a second modification of the present embodiment will be described.

[0126] The intraoral photography auxiliary tool 23 has the same components as the above-mentioned intraoral photography auxiliary tool 3, and further, the main body 231 has at least one hole 243. The hole 243 passes through the inside and outside of the main body 231. Through such a hole 243, the determination subject 7 who bites the intraoral photography auxiliary tool 23 can breathe easily, which can give the determination subject 7 a sense of security. In addition, the size, number and arrangement of the holes 243 can be appropriately set so that the saliva of the determination subject 7 is not easy to enter.

[0127] The components of the second modification, such as the guide portion, can also be applied to the embodiment and the first modification.

[0128] 2-4 Modification 3 of the intraoral photography aid

[0129] Reference Fig. 9 and Fig.10 Next, an intraoral imaging assisting tool 43 according to a third modification of the present embodiment will be described. The intraoral imaging assisting tool 43 includes the same components as those of the intraoral imaging assisting tool 3 described above.

[0130] The main body 431 of the intraoral photography auxiliary tool 43 is a transparent or translucent resin molded product. Therefore, the shooting area of ​​the intraoral photography device 5 is wider than the range observed from the window 433A, and a wider field of view can be obtained. In addition, the inner diameter of the main body 431 is slightly reduced from the end 432 toward the end 433, thereby facilitating the resin molding of the intraoral photography auxiliary tool 43.

[0131] like Fig.10 As shown, the scale 437 is formed on the inner circumference of the main body 431, thereby making the outer circumference of the main body 431 smooth. The scale 437 may be a protrusion protruding from the inner circumference of the main body 431, or a mark displayed or applied on the inner circumference.

[0132] like Fig. 9As shown, the outer edge of the edge 434 is an ellipse that is long in the vertical direction, so that the intraoral photography auxiliary tool 43 can be easily positioned relative to the lips of the determination subject 7. In addition, the outer edge of the edge 434 is formed to protrude toward the end 433 or is thicker than other parts. As a result, the material amount and cost of the edge 434 are reduced and the necessary strength is ensured.

[0133] 2-5 Modification 4 of the intraoral photography aid

[0134] Reference Fig.11 and Fig.12 Next, an intraoral imaging assisting tool 530 according to a fourth modification of the present embodiment will be described. As shown in the figure, the intraoral imaging assisting tool 530 includes a cylindrical main body 531 having end portions 532 and 533 .

[0135] The end portion 532 is open to guide the camera device 57 of the intraoral camera 5 into the main body 531. The end portion 532 has a pair of edges 534 protruding toward the outside of the main body 531, and has a notch 537 that engages with a protrusion provided on the intraoral camera 5 to position the intraoral camera 5.

[0136] The opposite end 533 has a window 535 facing the imaging device 57 in the main body 531. Here, a transparent member covering the end 533 is assumed as the window 535, but the window 535 may be an opening provided in the end 533.

[0137] The pressing piece 536 extends from the main body 531. The pressing piece 536 functions as a tongue depressor to press the tongue 73 of the determination subject 7 so that the pharynx 72 of the determination subject 7 can be clearly seen from the camera device 57 in the main body 531. Fig.12 As shown, the pressing piece 536 is inclined so as to be away from the axis X of the main body 531 as it goes toward the throat portion 72 side.

[0138] In this way, the protection function of the camera device 57 and the function as a tongue depressor are respectively shared by the main body 531 and the pressing piece 536, so that the intraoral photography auxiliary tool 530 can be miniaturized. As a result, the burden (such as sobbing, choking) on ​​the determination subject 7 when the intraoral photography auxiliary tool 530 is installed can be reduced, and the convenience of the intraoral photography auxiliary tool 530 is improved.

[0139] 2-6 Modification 5 of the intraoral photography aid

[0140] Reference Fig.13 , Fig.14 , Fig.15Next, an intraoral photography assisting tool 630 according to a fifth modification of the present embodiment will be described. As shown in the figure, the intraoral photography assisting tool 630 includes a cylindrical main body 631 having end portions 632 and 633 .

[0141] The end portion 632 is formed with an opening 632A for guiding the camera device 57 of the intraoral camera device 5 into the main body 631. The end portion 632 has a pair of jaws 634 protruding toward the outside of the main body 631 and has an engaging protrusion 57A (see FIG. 5A ) provided on the camera device 57 of the intraoral camera device 5. Figure 6 ) is engaged to position the intra-oral photography device 5.

[0142] The end portion 633 located on the opposite side to the end portion 632 of the main body 631 has a window portion 635 that faces the front end of the imaging device 57 when the imaging device 57 is inserted into the main body 631. The window portion 635 can be formed, for example, by a transparent member that covers the end portion 633. However, the specific structure of the window portion 635 is not particularly limited as long as the imaging device 57 disposed in the main body 631 can capture the oral cavity 71 through the window portion 635. The window portion 635 can be, for example, an opening formed at the end portion 633.

[0143] In addition, regarding the window portion 635, when the window portion 635 is composed of a transparent member, for example, it can be composed of the same material as the constituent material of the main body 631, or it can be composed of a material different from the constituent material of the main body 631. In the case where the window portion 635 is composed of a material different from the constituent material of the main body 631, the window portion 635 can be configured in a manner having physical properties different from the physical properties of the constituent material of the main body 631. The material of the window portion 635 can be arbitrarily selected based on the viewpoints of strength, light transmittance, cost, ease of manufacturing operation, etc. according to the product specifications of the window portion 635.

[0144] Regarding the main body 631, when the main body 631 is made of a resin material, it can be manufactured by injection molding using a molding die. As described above, when the window portion 635 is made of a material different from the material of the main body 631, for example, injection molding can be used in which the resin material is injected into the molding die while the transparent member is set in the molding die.

[0145] like Fig.13 , Fig.14As shown, a deformable portion 632B can be formed at the end 632 of the main body 631. The deformable portion 632B can be connected to the opening 632A, for example, and is composed of a plurality of slits extending approximately linearly from the opening 632A side to the front end side of the main body 631 (the side where the end 633 is located). Each of the plurality of slits can be arranged at predetermined intervals along the circumferential direction of the main body 631. Each of the plurality of slits penetrates the outer surface of the main body 631 and the inner surface of the main body 631. In addition, the number and specific shape of the slits are not particularly limited.

[0146] When the user inserts the imaging device 57 into the main body 631 via the opening 632A formed at the end 632, the end 632 can be deformed in a manner that expands outward (in the direction away from the axis X) by the easily deformable portion 632B formed at the end 632. Therefore, in the case where the main body 631 is formed of a hard material that is difficult to deform, in the case where the outer shape (outer diameter) of the imaging device 57 is larger than the outer shape (inner diameter) of the opening 632A, even in the case where the outer shape of the imaging device 57 is different from the outer shape of the opening 632A, the user can easily insert the imaging device 57 into the main body 631 via the opening 632A formed at the end 632.

[0147] The specific configuration of the easily deformable portion 632B is not limited as long as it can improve the user operability when inserting the camera device 57 into the main body 631. For example, the easily deformable portion 632B may be configured by a thin-walled portion in which the wall thickness of the end portion 632 is thinner than that of other portions of the main body 631, a soft portion in which the end portion 632 is made of a material softer than that of other portions of the main body 631, or a configuration in which these configurations and a slit are selectively combined.

[0148] like Fig.13 , Fig.14 As shown, the main body 631 has a pressing piece 636 extending toward the front end side of the main body 631.

[0149] The pressing piece 636 is different from the pressing piece 536 (see Fig.12 ) Similarly, when the image of the oral cavity 71 is captured by the imaging device 57, the tongue 73 of the determination subject 7 is pressed. The user can clearly see the pharynx 72 by pressing the tongue 73 of the determination subject 7 downward using the pressing piece 636.

[0150] like Fig.14 As shown, the pressing piece 636 is inclined in a manner away from the axis X of the main body 631 as it moves toward the throat 72 side. Fig.13As shown by arrows A1-A2, the pressing piece 636 can be formed, for example, in a manner having a convexly curved shape relative to a direction intersecting the protruding direction of the pressing piece 636 (the left-right direction when the main body 631 is viewed from the front). Fig.13 As shown by arrow B1 - B2 , the pressing piece 636 can be formed, for example, in a shape that is convexly curved with respect to the protruding direction of the pressing piece 636 .

[0151] When the user uses the intraoral photography assisting tool 630 to assist photography of the oral cavity 71, the user can press the curved pressing piece 636 against the tongue 73 of the subject 7, thereby making the pressing piece 636 fit the shape of the rounded tongue 73. Therefore, while the user is using the intraoral photography assisting tool 630, it is possible to suppress the positional displacement of the pressing piece 636 from the tongue 73. In addition, while the subject 7 is pressing the pressing piece 636 against the tongue 73, the pressing piece 636 is arranged along the shape of the rounded tongue 73, thereby reducing the discomfort felt by the tongue 73.

[0152] When the pressing piece 636 is formed to be convexly curved in each of the direction intersecting the protruding direction of the pressing piece 636 and the protruding direction of the pressing piece 636 , the curvature of the pressing piece 636 in each direction is not particularly limited.

[0153] In addition, the pressing piece 636 may be formed in a manner that does not fall within the viewing angle of the camera device 57 during the use of the intraoral photography auxiliary tool 630 to assist in the photography of the oral cavity 71 of the determination subject 7, or may be formed in a manner that falls within the viewing angle of the camera device 57. In the case where the pressing piece 636 is formed in a manner that does not fall within the viewing angle of the camera device 57, since the pressing piece 636 is not reflected in the photographed image, a clear image of the pharynx 72 can be obtained. On the other hand, in the case where the pressing piece 636 is formed in a manner that falls within the viewing angle of the camera device 57, the user can visually confirm the position of the pressing piece 636 during the photography, and can therefore operate with a sense of security.

[0154] like Fig.15 As shown, when the pressing piece 636 is arranged on the lower surface (tongue side surface) of the pressing piece 636 against the tongue 73 of the determination subject 7, a slide suppression portion 636A for suppressing positional displacement of the pressing piece 636 from the tongue 73 can be formed.

[0155] The slide suppressing portion 636A may be composed of, for example, a concave-convex portion formed by texturing. The concave-convex portion formed by texturing increases the frictional force generated between the tongue 73 and the lower surface of the pressing piece 636, thereby preventing the pressing piece 636 from being displaced from the tongue 73. In addition, the slide suppressing portion 636A may be configured in a specific manner as long as it can prevent the pressing piece 636 from being displaced from the tongue 73. The slide suppressing portion 636A may be configured by, for example, a coating for increasing frictional force, a groove having a concave-convex shape, a portion formed with a large surface roughness, a combination thereof, and the like. In addition, the slide suppressing portion 636A may be formed on the entire lower surface of the pressing piece 636, or may be formed on only a portion of the lower surface of the pressing piece 636.

[0156] The pressing sheet 636 can be provided with a pattern (e.g., a text symbol), a pattern, a color, a mark, a scent, a flavor, or any combination thereof. By adopting such a structure, for example, when the determination subject 7 is a child, the anxiety and pressure felt by the determination subject 7 can be alleviated. In addition, the above-mentioned pattern and the like can also be added to the main body 631.

[0157] 2-7 Other Variations of Intraoral Photography Aids

[0158] The main body 31 does not need to have substantially the same inner diameter from the end 32 to the end 33. For example, the main body 31 may be configured so that the inner diameter increases toward the end 32. With such a trumpet-shaped main body 31, a plurality of intraoral photography auxiliary instruments 3 can be overlapped, and the space for transportation and storage can be reduced.

[0159] In addition, although the intraoral photography auxiliary tool 3 is envisioned to be an integrally molded resin product, it can also be made using a raw material such as elastic rubber, and can also be designed to be worn like a condom to cover all or part of the intraoral photography device 5.

[0160] In addition, a camera mounted on a smartphone or a tablet terminal may be used as the imaging device 57. In order to fix the positional relationship between such a camera and the intraoral photography auxiliary tool 3 (opening 32A), a frame or a clip may be provided on the main body 31 or the edge 34. For example, the intraoral photography auxiliary tool 3 may include a clip for clamping a smartphone from the upper edge or the horizontal edge, or an L-shaped frame for pushing to the corner of the smartphone.

[0161] The structures of the intraoral imaging assisting tools described in the embodiment and the modifications can be appropriately combined as long as the essential functions of the intraoral imaging assisting tools are not impaired.

[0162] 2-8 Packaging example of intraoral photography aids

[0163] The intraoral photography aid 3 can be sterilized, such as Fig.16 Thus, the intraoral imaging auxiliary tool 3 can be hygienically managed by individually packaging it in the bag 9 on which the identifier 91 is displayed. Alternatively, the identifier 91 may be displayed on the intraoral imaging auxiliary tool 3 .

[0164] The identifier 91 includes, for example, identification information including the product ID of the intraoral imaging auxiliary device 3. As the identifier 91, for example, a barcode and an RF tag can be cited, but a barcode is preferred in consideration of reading by the intraoral imaging device 5 and use of the medical device 1 in a medical institution. As the barcode, a one-dimensional barcode or a two-dimensional barcode can be used.

[0165] For example, before intraoral photography, the camera device 57 photographs the identifier 91, and the identification information of the intraoral photography auxiliary tool 3 in the bag 9 is read into the intraoral photography device 5, so that the batch information of the corresponding intraoral photography auxiliary tool 3 can be confirmed. Thus, even if a harmful event occurs to the patient due to contact with the oral cavity, traceability can be ensured, and the reuse of the intraoral photography auxiliary tool 3 can be detected, so that contamination and secondary infection caused by this can be prevented, and safety in terms of hygiene can be ensured.

[0166] 3-1 Intraoral photography device

[0167] Reference Figure 17-Figure 25 , the intraoral photography device 5 will be described in detail.

[0168] The intraoral imaging device 5 is a computer including an imaging device, a computing device, and a storage device. It is assumed here that the intraoral imaging device 5 is composed of one computer, but it can also be composed of multiple computers. For example, in remote image diagnosis, the imaging function and the determination function can be performed by a single computer. Fig.18 As shown, the intraoral photographing device 5 includes a photographing device 57, a central processing unit (CPU) 51 as an example of a computing device, a random access memory (RAM) 52 as an example of a storage device and a read-only memory (ROM) 53, a communication interface 54, an input device 55, an output device 56 and a light source 58.

[0169] The communication interface 54 is a wired or wireless communication module, for example, used for obtaining and updating applications and judgment algorithms, and collecting (sending) captured images. As a wireless communication interface, for example, a device that satisfies any one of the wireless LAN standards such as Wi-Fi, the short-range wireless communication standards such as BLUETOOTH (registered trademark), and the third generation / fourth generation mobile communication standards is envisioned, but it is not limited thereto.

[0170] The input device 55 is an example of an input device for receiving user input, such as Fig.17 Alternatively, the input device 55 may be other input units such as a touch panel, a microphone, an operation dial, a stylus, etc. The input device 55 may be disposed on the main body (housing) of the intraoral photographing device 5, or may be disposed on, for example, the imaging device 57.

[0171] The output device 56 is an example of an output means for outputting the determination result, and is, for example, a display, a speaker, or a printer.

[0172] The image pickup device 57 acquires an image. In this embodiment, a moving image is assumed as the image acquired by the image pickup device 57. The acquired image size may be, for example, 640×480 pixels, and the frame rate may be, for example, 30 fps. However, the image size and frame rate are not limited to these.

[0173] Alternatively or additionally, the camera 57 may be configured to be capable of capturing still images. In the case of capturing still images, the camera 57 is preferably configured to have a continuous shooting function, but is not limited thereto.

[0174] In this embodiment, if Fig.17 As shown, it is assumed that the camera device 57 is separated from the main body (housing) of the intraoral photography device 5 and is separately inserted into the intraoral photography auxiliary tool 3. The camera device 57 also preferably has an outer shape (e.g., a cylindrical shape) corresponding to the inner circumference of the main body 31 of the intraoral photography auxiliary tool 3.

[0175] However, the imaging device 57 may be incorporated into the main body of the intraoral imaging apparatus 5 like a smartphone or a tablet terminal, for example.

[0176] The camera device 57 has an autofocus function (not shown), and can be set to focus on a specific part at the front of the lens, for example. The camera device 57 can also have a function of automatically identifying a specific part (for example, the posterior wall of the pharynx) and focusing on the part. The camera device 57 also has a zoom function, and can be set to shoot at an appropriate magnification according to the size of the posterior wall of the pharynx or the follicle, for example.

[0177] During the operation of the imaging device 57, light can be irradiated from the light source 58 toward the subject, thereby ensuring a high-quality image. Here, the light irradiated by the light source 58 can be visible light or non-visible light such as near infrared or infrared. In addition, for example, one light source can irradiate visible light and another light source can irradiate near infrared or infrared, so that multiple light sources 58 are responsible for irradiating light of a specific wavelength range.

[0178] In contrast, the imaging device 57 preferably has a light receiving element that can appropriately receive the type and amount of light emitted by the light source 58. For example, when the light source 58 emits visible light, the imaging device 57 may have a light receiving element suitable for receiving visible light, and when the light source 58 emits non-visible light, the imaging device 57 may have a light receiving element suitable for receiving non-visible light. The light source 58 may be, for example, a light emitting diode (LED) or an organic electroluminescent (OEL).

[0179] Alternatively, it may be programmed so that, during the operation of the imaging device 57, the image being captured and a semi-transparent illustration are displayed in an overlapping manner on the display as the output device 56. When the user moves the imaging device 57 so that the illustration overlaps with the image of the part corresponding to the illustration (e.g., uvula, palatine tonsil), an appropriate image for determination can be obtained.

[0180] The ROM 53 stores application programs for executing various processes of the intraoral imaging device 5 and algorithms for determining specific diseases. The ROM 53 may also store images acquired by the imaging device 57 and identification information of the intraoral imaging auxiliary device 3, various information input from the input device 55 (e.g., information of the determination subject 7), and determination results. The ROM 53 may be a built-in type or a removable type such as a USB memory or a MicroSD card, and may further include a storage area of ​​a storage device of an external computer such as an external server.

[0181] The CPU 51 can read the application program stored in the ROM 53 to the RAM 52 and execute various processes including the following processes (a) to (d). In addition, when the image acquired by the imaging device 57 is a single still image, the extraction process may be omitted.

[0182] 3-2 Main Processing Executed by the CPU

[0183] (a) Extraction Processing

[0184] The CPU 51 extracts at least one still image that meets a predetermined condition from the images obtained by the camera 57. For example, when the camera 57 captures a moving image, the CPU 51 extracts at least one still image from the plurality of still images included in the moving image. When capturing a moving image, the still images are recorded at a predetermined frame rate. The still images should include those in good shooting conditions and those in bad shooting conditions. As images to be used in the subsequent determination process, a number of still images in good shooting conditions are selected.

[0185] For example, based on a plurality of identical image data, it is possible to find in advance that when a specific shooting angle, a specific lighting level, a specific field of view width, a specific part (such as the pharynx) is depicted, and a specific part is focused on, all or part of the conditions, the accuracy of the diagnosis of a specific disease (such as influenza) is high, and use this as a criterion for judging whether the shooting conditions are good or bad. In the case of adopting such a criterion, for example, Fig.23 In this way, the extraction process goes through the following steps: sorting the images based on the depiction position of the photographed object (step S31), sorting the images according to the focus degree of a specific part (step S32), sorting the images according to the light irradiation state (step S33), and finally selecting several images that are at the top of the comprehensive order (step S34). In addition, the images can also be sorted based on the width of the field of view or the shooting angle before the comprehensive order is calculated. Alternatively, a deep learning function can also be used in the extraction process.

[0186] (b) Determination Process

[0187] CPU51 determines the possibility of a specific disease based on the image obtained from the camera 57 (for example, at least one still image obtained by the extraction process) and the determination algorithm stored in ROM53. The specific disease is influenza in this embodiment. In order to determine, the information of the determination object 7 (hereinafter referred to as patient information) input by the user via the input device 55 or obtained by other methods can be used together. Patient information includes, for example, age, gender, time elapsed from the onset of the disease, the presence or absence of various symptoms of influenza (cough, runny nose, chills, etc.), and contact history with other influenza patients. Patient information may also include race, genetic information, date, season, location information (latitude and longitude of the place of medical treatment), meteorological information (such as weather, temperature, etc.) and all or part of the information related to the prevalence of influenza in a certain period of time in a certain region.

[0188] Here, the decision algorithm can be, for example, Fig. 22 The steps shown are generated.

[0189] For example, in the case of influenza, first, a pharyngeal image of the patient and a correct answer label indicating whether it is influenza and attached to the pharyngeal image are collected in a medical institution (step S21). The correct answer label is assigned, for example, based on the results of a swab-based rapid influenza test, a PCR test, or a virus isolation and culture test received by the patient. Although PCR tests and virus isolation and culture tests take several weeks to determine the results, their results are suitable as correct answer labels because they show extremely high accuracy. In addition, the correct answer label can include not only image data but also the above-mentioned patient information.

[0190] Next, teacher data (image data) is generated in which the judgment result of the above-mentioned PCR test or virus isolation and culture test is labeled as the correct answer (step S22). Machine learning is performed based on the teacher data to generate a judgment algorithm (step S23). The judgment algorithm is an algorithm for judging whether the image is likely to contain influenza when an image is provided. As a result, the possibility of influenza can be quantified, for example, expressed as "98.5%".

[0191] Alternatively, for example, the determination of positive or negative may be performed, such as "determination: influenza positive" and "determination: influenza negative". In this case, in addition to the determination of positive or negative, the reliability of the determination may be quantified or expressed in a high, medium, and low level evaluation. Alternatively, the certainty of influenza may be expressed in a high, medium, and low level evaluation.

[0192] (c) Output processing

[0193] The CPU 51 outputs the result of the determination process. An example of the output method is display on a display or transmission to another computer.

[0194] (d) Acquisition of identification information of intraoral imaging aids

[0195] Optionally, before making a new judgment, the CPU 51 may request the user to input identification information of the intraoral photography auxiliary tool 3 used in the judgment. For example, when the user photographs the identifier 91 with the camera 57, the CPU 51 obtains the corresponding identification information of the intraoral photography auxiliary tool 3 from the image of the identifier 91.

[0196] Next, the CPU 51 searches the records in the ROM 53 to check whether there is a record that matches the corresponding intraoral imaging assisting instrument 3. Alternatively, the CPU 51 may check the use record of the intraoral imaging assisting instrument 3 on an external server.

[0197] If there is no consistent record, the CPU 51 allows a new determination. If there is a consistent record, the CPU 51 determines that the corresponding intraoral photography auxiliary device 3 has been used. Then, the CPU 51 can, for example, display an alarm on the display, or end a series of processing. That is, the CPU 51 can limit new determinations based on the search results.

[0198] 3-3 Functional composition of the intraoral camera

[0199] Fig.19The functional configuration of the intraoral imaging device 5 is shown. The intraoral imaging device 5 includes an imaging unit 61, an extraction unit 62, a determination unit 63, a camera control unit 64, a storage unit 65, an input unit 66, an output unit 67, and a communication unit 68. If the corresponding relationship with the hardware configuration of the intraoral imaging device 5 is shown, the imaging unit 61 corresponds to the imaging device 57, the extraction unit 62, the determination unit 63, and the camera control unit 64 correspond to the CPU 51, the storage unit 65 corresponds to the ROM 53, the input unit 66 corresponds to the input device 55, the output unit 67 corresponds to the output device 56, and the communication unit 68 corresponds to the communication interface 54. Here, the camera control unit 64 controls the imaging device 57 to realize various functions such as the autofocus function and the zoom function.

[0200] As other functions, the intraoral photographing device 5 may have a timing function for obtaining the time of photographing, a position information acquisition function for obtaining the position information of the photographing, and a weather information acquisition function for obtaining the weather information of the position. The timing function may be implemented as a built-in clock, or may be a function of a communication interface for accessing an external time server. The position information acquisition function may be implemented, for example, as a global positioning system (GPS). The weather information acquisition function may also be a function of a communication interface for accessing an external weather server.

[0201] 3-4 Example 1 of the operation of the intraoral imaging device

[0202] Reference Fig. 20 , an operation example 1 of the intraoral camera 5 will be described. Here, the operation when the intraoral camera 5 captures a moving image is taken as an example. However, the intraoral camera 5 may capture a still image, and in this case, the intraoral camera 5 also operates in the same manner.

[0203] When the power is turned on, the intraoral camera 5 starts to take pictures with the camera 57 and displays them on the display, and in step S1, it is determined whether the record button (one of the input devices 55) is pressed. If the record button is not pressed, the intraoral camera 5 repeats step S1.

[0204] When the recording button is confirmed to be pressed, the intraoral camera 5 starts recording in step S2. At the same time, the intraoral camera 5 turns on the light source 58. The user installs the intraoral camera auxiliary tool 3 in the oral cavity 71 of the determination subject 7, and then inserts the camera 57 into the intraoral camera auxiliary tool 3 (see FIG. Figure 1 The imaging device 57 also captures the inside of the mouth (the oral cavity 71 or the pharynx 72 ) of the determination subject 7 while the intraoral imaging assisting tool 3 is sliding inside the mouth.

[0205] In step S3, the intraoral imaging device 5 extracts an appropriate still image for determination from a plurality of still images included in the acquired moving image. At this time, the extracted still image may be displayed on a display as an extraction result.

[0206] In step S4 , the intraoral imaging device 5 determines the possibility of a specific disease based on the extracted still image and the determination algorithm, and in step S5 , outputs the determination result to, for example, a display. Thus, a series of operations are completed.

[0207] In this way, since the possibility of a specific disease is evaluated using a determination algorithm generated by machine learning, a highly accurate determination result can be expected.

[0208] Since an image captured under good conditions is selected for determination, the accuracy of determination is improved.

[0209] By using the intraoral imaging device 5 in combination with the intraoral imaging auxiliary tool 3, a clear image with a wide visual field can be obtained, which contributes to an improvement in determination accuracy.

[0210] 3-5 Example 2 of the operation of the intraoral imaging device

[0211] Reference Fig.21 , describing an operation example 2 of the intraoral imaging device 5. This operation example 2 includes the same steps as the previously described operation example 1, and further includes a step of confirming the extracted image by the user (S14), a step of inputting patient information (S16), and a comprehensive determination (S17).

[0212] Specifically, when the intraoral camera 5 is powered on, it confirms that the recording button is pressed (step S11), starts recording (step S12), and extracts an image for determination (step S13). Then, the intraoral camera 5 displays the extracted image on a display, for example, and asks the user to confirm whether to use the image for determination (step S14). If the user selects "no", steps S12 and S13 are executed again, and a new image for determination is presented to the user.

[0213] When the user selects “Yes” in step S14 , the intraoral imaging device 5 determines the possibility of a specific disease based on the extracted image (step S15 ).

[0214] Next, the intraoral camera 5 asks the user to input the patient information (step S16). Here, the patient information is simple and standardized information such as the body temperature at the time of the visit and the presence or absence of vaccination. Fig. 9As shown, the patient information is input in a form that can be uniformly processed by the software. For example, a drop-down menu may be used to reject input formats other than half-width numbers. Alternatively, the intraoral camera 5 may obtain the patient information from an external computer (e.g., an electronic medical record system) via a wired or wireless line. In addition, step S16 may also be executed before step S11.

[0215] Then, the patient information and the evaluation of the probability of a specific disease based on the image are combined to calculate the probability of the disease as a whole (step S17). The calculation result is displayed on a display, for example (step S18), and a series of steps are completed.

[0216] In this way, the intraoral imaging device 5 evaluates the possibility of a specific disease using images confirmed by the user, thereby improving the accuracy and reliability of determination.

[0217] Furthermore, if determination is performed based on patient information, it can be expected that the accuracy and reliability of determination will be further improved.

[0218] 3-6 Example 3 of the operation of the intraoral camera

[0219] Reference Fig.24 Next, an operation example 3 of the intraoral imaging device 5 will be described. The operation example 3 includes a step of acquiring identification information of the intraoral imaging auxiliary tool 3 (step S41).

[0220] Specifically, when the intraoral imaging device 5 is powered on, in step S41, the user is requested to input identification information of the intraoral imaging auxiliary tool 3 through, for example, a display on the monitor. For example, when the user uses the imaging device 57 to capture the identifier 91 on the bag 9, or inputs identification information through the input device 55, the intraoral imaging device 5 obtains the identification information of the intraoral imaging auxiliary tool 3.

[0221] The intraoral imaging device 5 may also use the identification information to check the batch information of the intraoral imaging auxiliary tool 3. For example, the intraoral imaging device 5 may search whether the record in the ROM 53 contains the product ID of the intraoral imaging auxiliary tool 3, or check whether the external computer has the product ID.

[0222] When the corresponding product ID exists in the internal or external records, the intraoral photography device 5 can output an alarm or end a series of processes. As an alarm, for example, a message that the intraoral photography auxiliary device 3 has been used can be displayed on the display. In this way, the reuse of the intraoral photography auxiliary device 3 is restricted, and the safety of the intraoral photography auxiliary device 3 including the prevention of secondary infection is improved. In addition, the intraoral photography auxiliary device 3 can be matched one-to-one with the determination subject 7 who uses the intraoral photography auxiliary device 3, so future follow-up investigations become easy.

[0223] Then, the intraoral imaging device 5 performs intraoral imaging in step S42. Here, the intraoral imaging process can be the same as the above-mentioned action examples 1 and 2, or can be performed according to the steps described later. In addition, the intraoral imaging device 5 determines the possibility of a specific disease in step S43, outputs the determination result in step S44, and ends a series of processing.

[0224] 3-7 Other examples of intraoral photography

[0225] Reference Fig.25 , other steps of intraoral photography are described. The steps described here can be substituted for the image acquisition steps in the above-mentioned operation examples 1 to 3. In addition, this step can be used to collect training data for machine learning.

[0226] First, in step S51, the intraoral imaging device 5 performs patient registration. Patient registration is performed, for example, by the user inputting the patient ID into the intraoral imaging device 5 or recording the imaged patient ID.

[0227] Next, in step S52, the intraoral imaging device 5 acquires an image. The image referred to here is a still image, and may be composed of, for example, a group of still images extracted from the image captured by the imaging device 57 at predetermined time intervals (for example, every 1 second).

[0228] Then, in step S53, the intraoral camera 5 displays the acquired image on a display, for example, and requests the user to confirm. If the user approves in step S54, the intraoral camera 5 saves the approved image in step S55, and ends a series of photographing processes. If the user approves, the process returns to step S52 and acquires the image again.

[0229] 4 Steps from oral imaging to administration of anti-influenza virus agent

[0230] Reference Fig.26 , explaining the steps from oral imaging to administration of anti-influenza virus agents.

[0231] In step S61, an intraoral image, particularly a pharyngeal image, is captured using the intraoral imaging device 5. At this time, in order to obtain a clear image, any of the above-mentioned intraoral imaging auxiliary tools 3 (including the tools shown in the modified examples) may be used.

[0232] Next, in step S62, the intraoral image is used to determine whether the influenza virus infection is positive or negative. For example, this step preferably includes determining whether a pattern unique to influenza virus infection appears in the pharynx. This step can be performed by using the intraoral camera 5.

[0233] Then, when the result of determination in step S62 is negative for influenza virus infection, a series of steps are terminated.

[0234] On the contrary, when the result of the determination is positive for influenza virus infection, in step S63, an anti-influenza virus agent is administered to the patient, and a series of steps are terminated. Thus, the anti-influenza virus agent can be administered quickly and accurately to a patient suspected of influenza virus infection, and efficient treatment of influenza becomes possible. In addition, by administering an anti-influenza virus agent to a patient determined to be positive for influenza virus infection, the generation of drug-resistant strains, which has become a global social problem represented by Japan, can be prevented.

[0235] Here, examples of anti-influenza virus agents include baloxavir, oseltamivir, zanamivir, peramivir and laninamivir, but are not limited to these low molecular weight drugs and may also include other low molecular weight compounds having antiviral effects, peptide drugs, antibody drugs, nucleic acid drugs, and vaccines.

[0236] As low-molecular drugs with antiviral effects, there can be mentioned compounds with Cap endonuclease inhibitory effects, such as baloxavir; compounds with neuraminidase inhibitory effects, such as laninamivir, zanamivir, and AV-5080, an analog of zanamivir; compounds with RNA polymerase inhibitory effects, such as favipiravir; compounds with PB2 protein inhibitory effects, such as pimodivir and CC-42344; compounds with antiviral effects, such as nitazoxanide and tizoxanid; and compounds with G protein-coupled receptor (GPCR) antagonistic effects, such as GP-1001, etc.

[0237] Examples of peptide drugs with antiviral effects include fluorouracil-3 (flufirvitide-3) consisting of 16 amino acid residues that targets hemagglutinin HA2 of influenza virus, PD-001 (HA100, HA100-R14, iHA-100, iHA-24) that is a cyclic peptide that targets hemagglutinin (HA), peptides disclosed in US Pat. No. 7,645,448 and its homologues (e.g., DAS-181) that target hemagglutinin (HA), TCN-032 that is a fully human monoclonal IgG antibody that uses the extracellular amino terminal region (M2e) of the matrix protein M2 of influenza A virus as an antigen, and VIS-410 that is a human IgG1 monoclonal antibody that has a broad spectrum against influenza viruses and inhibits the fusion of hemagglutinin (HA) with cell membranes.

[0238] Antibody drugs with antiviral effects include: gedivumab, a recombinant human monoclonal IgG1κ antibody against influenza A, MEDI-8852, an IgG1κ monoclonal antibody that binds to the stem region of hemagglutinin (HA) subtypes H5 and H7, and CF-404, a mixture of three human monoclonal antibodies disclosed in WO2014152841 and its homologues and targeting the conservation region of hemagglutinin (HA) of influenza virus.

[0239] Examples of nucleic acids having an antiviral effect include radavirsen, which is an antisense RNA / DNA consisting of 20 bases, and STP-702, which is a mixture of siRNAs targeting influenza virus genes of 5N1, H1N1, and H7N9.

[0240] Examples of influenza vaccines include: the inactivated whole-particle nasal influenza vaccine disclosed in WO2014103488 and its homologues (BK-1304); intradermal influenza vaccines (DNK-651, KD-404); nasal spray-type quadrivalent attenuated live vaccines (MEDI-3250 / VN-0107 / FluMist (registered trademark) Quadrivalent / Fluenz (registered trademark) Tetra); sublingual tablet preparations of influenza HA vaccines ( NSV-0001); pandemic influenza vaccines using recombinant hemagglutinin (HA) produced by transgenic silkworms as antigens disclosed in WO2014017493 and its family; monovalent influenza VLP vaccines against influenza A; intranasal recombinant pandemic influenza vaccines using replication-defective adenovirus vectors targeting influenza hemagglutinin (HA); intranasal recombinant seasonal influenza vaccines using replication-defective adenovirus vectors targeting influenza hemagglutinin (HA); H5 N1 avian influenza vaccine (AE-443p); A virus replicon vaccine expressing the influenza HA protein (AVX-502); A DNA vaccine synthesized by incorporating the gene of the hemagglutination (HA) influenza antigen from patients infected with influenza H7N9 into the pGX0001 expression vector (pH7HA / GLS-3700); An inactivated trivalent influenza vaccine using AS03 adjuvant (GSK-2186877A); An inactivated trivalent influenza vaccine containing AS03 adjuvant and using the hemagglutination (HA) influenza antigen of influenza virus The vaccine is a DNA vaccine for influenza A virus (H7N9) containing HA as an antigen (GSK-3206641A); a DNA vaccine for influenza A virus (pH3HA) targeting H3N2 virus; a DNA vaccine for intradermal administration using electroporation (INO-3510) containing influenza A virus H5N1 vaccine (INO-3401) and H1N1 vaccine (INO-3605 and INO-3609); and a RedeeFluTM vaccine composed of influenza virus with a partial deletion of the M2 gene (Bris10 M2SR); a vaccine (MER-4101) that uses three standard seasonal inactive influenza antigens in a nanoparticle W / O emulsion formulation using Mercia Pharma's MAS-1 (Mercia Adjuvant / delivery System-1); a vaccine (mRNA-1851) that uses mRNA encoding the membrane-bound hemagglutinin protein H7; a vaccine (MT-8972) that targets the Indonesian influenza A virus (A / Indonesia / 5 / 2005) disclosed in WO2009009876 and its family;H5 influenza vaccine (nanoemulsion adjuvanted H5 influenza vaccine) containing plant-derived influenza (influenza A / Indonesia / 5 / 2005) HA antigen (H5) to induce anti-H5 antibodies; vaccine (PDS-0103) in which influenza antigens are encapsulated in nanoparticles composed of cationic lipids (DOTAP); quadrivalent influenza vaccine targeting 1N1 (A / California / 04 / 09), H3N2 (A / Victoria361 / 2011) and two B-type strains (B / Wisconsin / 1 / 2010, B / Brisbane / 60 / 2008), and using Nicotiana benthamiana (Nicotiana benthamiana) vaccine (MT-2271); H5N1 influenza vaccine in which the H5HA antigen of the H5N1 influenza virus (A / Vietnam / 1194 / 2004) is assembled into an adenovirus vector (Ad4) and replicated in the small intestine to induce an antibody response (PXVX-0103); VLPs (corevirus-like A quadrivalent seasonal influenza vaccine containing influenza B produced using the SARS-CoV-2 particle technology; a quadrivalent oral vaccine for seasonal influenza, containing an adenovirus (Ad5) encoding dsRNA for HA antigen and TLR3 ligand, which is absorbed from the small intestine, activates dendritic cells through TLR3 ligand, and induces antibody production; and a DNA vaccine for the prevention of H5N1 and H7N9 avian influenza viruses, containing three DNA plasmids, including universal consensus hemagglutinin (HA) from multiple different H5N1 virus sources, universal consensus neuraminidase (NA) covering N1 subtypes such as H5N1 and H1N1, and universal consensus nucleoprotein (NP) fused to a part of the m2 protein (m2e), etc. (VGX-3400X). ;

[0241] In step S63, it is also possible to administer an anti-influenza virus agent to a close contact of a patient who is determined to be positive for influenza virus infection. Thus, it is possible to prevent influenza virus infection of a close contact of a patient suspected of being infected with influenza virus, and it is possible to effectively suppress the expansion of influenza virus infection. Especially in the case where a close contact is an elderly person over 65 years old, a chronic respiratory disease or a chronic heart disease patient, a patient with a metabolic disease including diabetes or a patient with renal dysfunction who may become a high-risk patient when infected with influenza virus infection, it is possible to expect a larger preventive effect. Here, a close contact, for example, refers to acting together with a patient who is determined to be suspected of influenza virus infection, or making contact, or a person sitting in a neighboring seat, such as an airplane / workplace, including a cohabiting family member and a person living together.

[0242] As mentioned above, although the typical embodiment of this invention was demonstrated, this invention is not limited to this, Various design changes are possible, and these are also included in this invention.

[0243] For example, the present invention can be understood as a method for treating and a method for preventing influenza virus infection, and a therapeutic agent and a preventive agent containing an anti-influenza virus agent as an active ingredient.

[0244] The therapeutic method of the present invention, more specifically, relates to a method for treating influenza virus infection, which is a method for treating influenza virus infection containing an anti-influenza virus agent as an active ingredient, wherein:

[0245] (1) Using an intraoral imaging device to perform an image diagnosis of influenza infection in the mouth of a patient suspected of influenza virus infection, and identifying and selecting patients who are positive for influenza virus infection,

[0246] (2) The above-mentioned anti-influenza virus agent is administered to a patient who is diagnosed as positive for influenza virus infection.

[0247] In addition, as a therapeutic agent, it may involve a therapeutic agent for influenza virus infection, characterized in that it is a therapeutic agent for influenza virus infection containing an anti-influenza virus agent as an active ingredient, and the anti-influenza virus agent is administered to a patient who is determined to be positive for influenza virus infection by using an intraoral image taken using an intraoral photography device.

[0248] Alternatively, the present invention can also be understood as the use of an active ingredient for manufacturing an anti-influenza virus agent for treating and preventing influenza virus infection. More specifically, the present invention relates to the use of an active ingredient for manufacturing an anti-influenza virus agent for treating influenza virus infection, characterized in that:

[0249] (1) Using an intraoral imaging device to perform an image diagnosis of influenza infection in the mouth of a patient suspected of influenza virus infection, and identifying and selecting patients who are positive for influenza virus infection,

[0250] (2) The above-mentioned anti-influenza virus agent is administered to a patient who is diagnosed as positive for influenza virus infection.

[0251] In the present embodiment, anti-influenza virus agents are applied to patients and close contacts thereof who are judged to be positive for influenza virus infection, but even if it is a subject (negative determination person) who is judged to be negative for influenza virus infection, anti-influenza virus agents can also be applied to the personnel of the patients with influenza infection in their close contacts. Thus, it is possible to prevent influenza virus infection for the personnel who are worried about being infected with influenza virus, and it is possible to effectively suppress the expansion of influenza virus infection. Especially when the negative determination person is an elderly person over 65 years old, a patient with chronic respiratory disease or chronic heart disease, a patient with metabolic disease including diabetes, or a patient with renal dysfunction, a greater preventive effect can be expected.

[0252] Explanation of symbols

[0253] 1···Medical Devices,

[0254] 3, 13, 23, 43, 530, 630···Intraoral photography aids,

[0255] 5···Intraoral camera device,

[0256] 31, 131, 231, 431, 531, 631... Main body,

[0257] 34, 134, 234, 434, 534, 634··· along the edge,

[0258] 35, 135, 435, etc. Restriction Department,

[0259] 37, 137, 237, 437... scale,

[0260] 55···Input devices,

[0261] 56···Output devices,

[0262] 57···Camera equipment,

[0263] 58···Light source.

Claims

1. An intraoral photography auxiliary device, which is inserted into the oral cavity for photography of the oral cavity, and comprises a main body and a pressing piece; The main body is a cylindrical main body, comprising: The first end has an opening into which a camera device can be inserted, a second end portion, located on the opposite side of the first end portion, providing a view from the inside of the body to the outside of the body, and an inner peripheral surface extending from the first end portion to the second end portion to allow sliding movement of the imaging device; The pressing piece is formed so that one end is connected to the main body and the other end is located outside the second end portion and extends in the longitudinal direction of the main body.

2. The intraoral photography aid according to claim 1, wherein: The pressing piece presses the tongue of the determination subject into which the intraoral photography assisting tool is inserted, when the intraoral photography assisting tool is inserted into the oral cavity.

3. The intraoral photography aid according to claim 1, wherein: The pressing piece is formed such that the other end is separated from the longitudinal axis of the main body.

4. The intraoral photography aid according to claim 1, wherein: The pressing piece is formed so as to protrude from the second end portion in a protruding direction further outward than the second end portion. 5 . The intraoral photography assisting tool according to claim 4 , wherein the pressing piece has a shape that is convexly curved with respect to the protruding direction.

6. The intraoral photography aid according to claim 1, wherein: The second end portion has a window portion covered by a transparent member formed integrally with the main body.

7. The intraoral photography aid according to claim 1, wherein: The first end portion has an easily deformable portion for assisting insertion of the imaging device into the main body.

8. The intraoral photography auxiliary device according to claim 7, wherein: The easy-to-deform portion is composed of a plurality of slits arranged at predetermined intervals in a circumferential direction of the body, and the plurality of slits extend from the opening toward the second end portion.

9. The intraoral photography auxiliary device according to claim 1, wherein: The first end portion has a notch that engages with a protrusion provided on the imaging device to position the imaging device.

10. The intraoral photography auxiliary device according to claim 1, wherein: The first end portion has a flange portion that is partially formed around the main body so as to protrude from the main body toward the outside in the radial direction of the main body. 11 . The intraoral photography assisting tool according to claim 10 , wherein the edge portion has a through hole penetrating in a direction along the longitudinal direction of the main body.

Images