Preparation method of wall-broken lucid ganoderma superfine powder for female insomnia

Abstract

The invention relates to the technical field of biological medicines, and discloses a preparation method of ganoderma lucidum wall-broken superfine powder for female insomnia, which is characterized in that thick ganoderma lucidum slices are subjected to spray moistening, hot-pressing steam heating, ultrasonic treatment, microwave drying and other process treatments, so that the contents of polysaccharides, triterpenes and sterols are increased; and the release rate of the active ingredients is also obviously improved. According to the technology, the structure of the cell wall of the ganoderma lucidum mycelium is destroyed, so that active ingredients such as polysaccharide, triterpenes and sterol originally existing in ganoderma lucidum can be easily extracted and released. Ganoderma lucidum cells are loosened and broken, polysaccharide in a combined state can be changed into a free state, and the content of ganoderma lucidum polysaccharide can be greatly increased. The cell-broken ganoderma lucidum wall-broken superfine powder can be directly taken in digestive tracts to quickly release active ingredients in ganoderma lucidum to the maximum extent, and the effect of improving female insomnia by the superfine powder is improved.

Description

Technical Field

[0001] The invention relates to the technical field of biomedicine, and in particular to a method for preparing ganoderma lucidum wall-broken ultrafine powder for treating female insomnia. Background Art

[0002] Ganoderma lucidum is the dried fruiting body of the fungus Ganoderma lucidum or Ganoderma rubrum of the Polyporaceae family. It has the functions of replenishing qi and calming the mind, relieving cough and relieving asthma. It can be used for restlessness, insomnia and palpitations, cough and asthma caused by lung deficiency, shortness of breath due to consumptive disease, and loss of appetite. Modern research shows that Ganoderma lucidum has the effects of enhancing immunity, anti-tumor, anti-virus, anti-oxidation, anti-aging, anti-fatigue, and anti-hypoxia. The active ingredients in Ganoderma lucidum include polysaccharides, triterpenes and sterols, amino acid polypeptides, and nucleosides and alkaloids, among which Ganoderma lucidum polysaccharides are the main active ingredients of Ganoderma lucidum. Therefore, the content of Ganoderma lucidum polysaccharides in Ganoderma lucidum and the ease of release of Ganoderma lucidum's active ingredients from Ganoderma lucidum directly affect the effectiveness of Ganoderma lucidum. Increasing the content of Ganoderma lucidum polysaccharides and increasing the release rate and amount of active ingredients in Ganoderma lucidum are important means to improve the effectiveness of Ganoderma lucidum.

[0003] Ganoderma lucidum polysaccharides exist in free and bound forms. Free polysaccharides, amino acids, and small molecule polypeptides are soluble and can be used by the human body to play a role. Bound polysaccharides, proteins, and chitosan are insoluble and cannot be extracted or released by conventional methods, and cannot be used by the human body. According to the technology of the present invention, bound polysaccharides can be converted into free polysaccharides, thereby increasing the content of polysaccharides in Ganoderma lucidum.

[0004] The mycelium walls of Ganoderma lucidum fruiting bodies are thick and intertwined. The cell walls, which are composed of glucan, chitin, cellulose, hemicellulose, lignin, protein, etc., are tough in texture, have high mechanical strength, are resistant to pressure and temperature, and are very stable to digestive enzymes. The polysaccharides and other effective substances it contains are difficult to be fully extracted and utilized. Summary of the invention

[0005] The technical problem solved by the present invention is: to provide a method for preparing ganoderma lucidum wall-broken ultrafine powder with high polysaccharide, triterpenoid and sterol content, which can be used to improve female insomnia.

[0006] The technical solution provided by the present invention is: a method for preparing superfine powder of broken ganoderma lucidum for female insomnia:

[0007] (1) Wash the dried Ganoderma lucidum or Ganoderma lucidum fruiting bodies with water and cut them into thick slices.

[0008] (2) Spraying the thick slices of Ganoderma lucidum with distilled water to moisten them thoroughly. Spraying, rather than soaking, can moisten the thick slices of Ganoderma lucidum without causing loss of the active ingredients of Ganoderma lucidum.

[0009] (3) placing the soaked thick slices of Ganoderma lucidum in a hot-pressed steam cabinet, sealing it, evacuating it, introducing hot-pressed steam, heating it, and then quickly releasing the steam to cool it.

[0010] (4) placing the heated Ganoderma lucidum thick slices in an ultrasonic processor for ultrasonic treatment.

[0011] (5) placing the ultrasonically treated thick slices of Ganoderma lucidum in a microwave dryer for drying.

[0012] (6) Grinding the dried thick slices of Ganoderma lucidum into ultrafine powder to obtain the broken-wall ultrafine powder of Ganoderma lucidum for treating insomnia in women.

[0013] Preferably, in (1), the thickness of the Ganoderma lucidum slices is 2-4 mm.

[0014] Preferably, in (2), the soaking time is 2-4 hours.

[0015] Preferably, in (3), the pressure in the autoclave is controlled to be 105-137 kPa by introducing autoclave steam, and the heating treatment time is 2-4 h.

[0016] Preferably, in (3), after the heating treatment, the hot steam in the autoclave is completely released within 2-5 minutes.

[0017] Preferably, in (4), the conditions for ultrasonic treatment are power 200-300 W, frequency 20-25 kHz, and time 60-90 min.

[0018] Preferably, in (5), the microwave frequency in the microwave dryer is 2400-2500 MHz, the drying temperature is 60-70° C., and the drying time is 20-30 min.

[0019] Preferably, in (6), the dried thick slices of Ganoderma lucidum are placed in an ultrafine pulverizer or a jet mill to break the wall and pulverize into ultrafine powder.

[0020] Preferably, in step (6), the quality requirements for the Ganoderma lucidum broken wall ultrafine powder include the following: moisture ≦17%, water-soluble extract ≧3.0%, polysaccharide content ≧2.00%, triterpene and sterol content ≧1.0%, 90% of the ultrafine powder particle size in the Ganoderma lucidum broken wall ultrafine powder ≦30μm, and there must be no particles exceeding 40μm.

[0021] The technical effect produced by the present invention is: after the thick slices of Ganoderma lucidum are treated by spraying, hot-pressing steam heating, ultrasonic treatment and microwave drying, not only the content of polysaccharides, triterpenes and sterols is increased, but also the release rate of active ingredients is significantly increased. Moreover, whether it is ordinary fine powder or ultrafine powder, its release rate is much faster than that of Ganoderma lucidum powder of corresponding particle size that has not been treated by the technology of the present invention, which is beneficial to improve the effectiveness of Ganoderma lucidum powder for female insomnia patients. The reason is not that the technology of the present invention converts other components in Ganoderma lucidum into active components, but that the structure of the cell wall of Ganoderma lucidum mycelium is destroyed by the technology of the present invention, so that the active components such as polysaccharides, triterpenes and sterols originally present in Ganoderma lucidum can be easily extracted and released, so their content increases during measurement. When measuring the content of active components of Ganoderma lucidum that has not been treated, the components cannot be completely extracted because the cell wall of Ganoderma lucidum mycelium is hard, and the measurement result is low.

[0022] The method of the present invention can loosen and break the ganoderma cells, and can make the bound polysaccharide become free, which can greatly increase the content of ganoderma polysaccharide. The cell-broken ganoderma wall-broken ultrafine powder can be directly taken in the digestive tract to quickly release the active ingredients in the ganoderma in the largest amount, which is beneficial to improve the effect of the ultrafine powder on improving female insomnia. DETAILED DESCRIPTION

[0023] (1) Wash the dried Ganoderma lucidum or Ganoderma odoratum fruiting bodies with water and cut them into 2-4 mm thick slices. The purpose of this operation is to reduce the time required to thoroughly moisten the Ganoderma lucidum with water in the next step.

[0024] (2) Using a spraying method, the thick slices of Ganoderma lucidum are sprayed with distilled water to make them moist.

[0025] (3) placing the thoroughly moistened thick slices of Ganoderma lucidum in a hot-pressed steam cabinet, sealing it, evacuating it, introducing hot-pressed steam, controlling the pressure in the hot-pressed steam cabinet to be 105-137 kPa, heating it for 2-4 hours, and then completely releasing the hot steam in the hot-pressed steam cabinet within 2-5 minutes.

[0026] (4) placing the heated Ganoderma lucidum thick slices in an ultrasonic processor for ultrasonic treatment at an ultrasonic power of 200-300 W, a frequency of 20-25 kHz, and a time of 60-90 min.

[0027] (5) The ultrasonically treated thick slices of Ganoderma lucidum are placed in a microwave dryer for drying, with the microwave frequency controlled at 2400-2500 MHz, the drying temperature at 60-70° C., and the drying time at 20-30 min.

[0028] (6) The dried thick slices of Ganoderma lucidum are placed in an ultrafine pulverizer or a jet mill to break the wall and pulverize into ultrafine powder, thereby obtaining ultrafine powder for treating insomnia in women. The quality requirements for ultrafine powder include the following: moisture ≦17%, water-soluble extract ≧3.0%, polysaccharide content ≧2.00%, triterpenoid and sterol content ≧1.0%, 90% of the ultrafine powder particle size of the ultrafine powder ≦30 μm, and no particles exceeding 40 μm are allowed.

[0029] Example 1

[0030] Clean the Ganoderma lucidum fruiting bodies and cut them into very thin slices with an average thickness of 0.4mm, thin slices with an average thickness of 1.5mm, and thick slices with an average thickness of 3mm according to the requirements of the slicing under the general rules of processing in the Chinese Pharmacopoeia. Collect the Ganoderma lucidum slices, weigh them, and calculate the loss rate. The results show that the loss rates are 28.5% for very thin slices, 16.2% for thin slices, and 4.3% for thick slices. So it is decided to cut them into thick slices.

[0031] Loss rate = (m 0 -m) / m 0 ×100%.m 0 is the mass of the Ganoderma lucidum fruiting body. m is the mass of the Ganoderma lucidum slices obtained. The results are shown in the table below.

[0032] Film type Ultra-thin slices Thin slice Thick slice Loss rate (%) 28.5％ 16.2％ 4.3％

[0033] Example 2

[0034] Clean the Ganoderma lucidum fruiting bodies, and use distilled water to spray and soak the Ganoderma lucidum (unsliced) and thick slices (average thickness 3mm). Break or cut the slices open every hour to observe the moisture content of the Ganoderma lucidum.

[0035] Results The soaking time of uncut Ganoderma lucidum was ≥12 hours, and the soaking time of thick slices was 2-4 hours. Slicing into thick slices can significantly reduce the soaking time.

[0036] Example 3

[0037] Clean the Ganoderma lucidum fruiting bodies and cut them into thick slices with an average thickness of 3 mm, then soak the thick slices (average thickness 3 mm) with distilled water. Place them in a hot pressure steam cabinet, seal them, evacuate them, pass hot pressure steam, control the pressure in the hot pressure steam cabinet to 100-137 kpa, heat them for 2 hours, and then completely release the hot steam in the hot pressure steam cabinet within 3 minutes. After cooling to room temperature, take out the thick slices of Ganoderma lucidum, and determine the content of Ganoderma lucidum polysaccharides and the content of triterpenes and sterols according to the method of the Chinese Pharmacopoeia. The results are shown in the table below.

[0038]

[0039] From the table above, we can see that the higher the pressure after the hot steam is introduced, the more polysaccharides, triterpenes and sterols in Ganoderma lucidum are found. The pressure increases significantly when it is ≥ 105 kpa, but if the pressure is too high, the operation is unsafe. Therefore, the pressure is controlled to 105-137 kpa.

[0040] Example 4

[0041] The fruiting bodies of Ganoderma lucidum were cleaned and cut into slices with an average thickness of 3 mm, and then the slices (average thickness of 3 mm) were soaked with distilled water. They were placed in a hot-pressed steam cabinet, sealed, evacuated, and hot-pressed steam was introduced. The pressure in the hot-pressed steam cabinet was controlled to be 125 kPa, and the heating treatment was performed for 1-6 hours. After naturally cooling to room temperature, the slices were taken out and the content of Ganoderma lucidum polysaccharides and the content of triterpenes and sterols were determined according to the method of the Chinese Pharmacopoeia. The results are shown in the table below.

[0042] Steam heating time 1 2 4 6 Polysaccharide content (%) 1.33 2.27 2.40 2.39 Triterpenes and sterols (%) 0.67 0.78 0.77 0.79

[0043] From the table above, we can see that the longer the steam heating time is, the higher the content of polysaccharides, triterpenes and sterols in Ganoderma lucidum is. When the heating time is more than 2 hours, the increase is obvious, but when the heating time exceeds 4 hours, the increase is lower. Therefore, the heating time is determined to be 2-4 hours.

[0044] Example 5

[0045] The fruiting bodies of Ganoderma lucidum were cleaned and cut into slices with an average thickness of 3 mm, and then the slices (average thickness 3 mm) were soaked with distilled water. They were placed in a hot-pressed steam cabinet, sealed, evacuated, and hot-pressed steam was introduced. The pressure in the hot-pressed steam cabinet was controlled to be 125 kPa, and the heat treatment was performed for 4 hours. The slices were cooled naturally to room temperature, or the air release valve was opened to quickly release the hot-pressed steam in the cabinet within 3 minutes. The slices were taken out and the content of Ganoderma lucidum polysaccharides and the content of triterpenes and sterols were determined according to the method of the Chinese Pharmacopoeia. The results are shown in the table below.

[0046] Hot press steam release method Natural cooling Quick release of steam Polysaccharide content (%) 2.39 3.02 Triterpenes and sterols (%) 0.79 0.91

[0047] As shown in the table above, the faster the hot steam release speed, the more polysaccharides, triterpenes and sterols in Ganoderma lucidum. When the release time is about 3 minutes, the content of active ingredients in Ganoderma lucidum can be significantly increased.

[0048] Example 6

[0049] The fruiting bodies of Ganoderma lucidum were cleaned and cut into thick slices with an average thickness of 3 mm, and then the thick slices of Ganoderma lucidum were soaked with distilled water. The slices were placed in a hot-pressed steam cabinet, sealed, evacuated, and hot-pressed steam was introduced. The pressure in the hot-pressed steam cabinet was controlled to be 125 kPa, and the heat treatment was performed for 4 hours. The vent valve was opened, and the hot-pressed steam in the cabinet was quickly released within 3 minutes. The slices were cooled, and the slices of Ganoderma lucidum were taken out and placed in an ultrasonic processor for ultrasonic treatment. The conditions for ultrasonic treatment were: power 250 W, frequency 25 kHz, and sampling every 30 minutes. The content of Ganoderma lucidum polysaccharide and the content of triterpenes and sterols were determined according to the method of the Chinese Pharmacopoeia.

[0050] The results are shown in the table below

[0051]

[0052] As shown in the table above, ultrasonic treatment can increase the content of active polysaccharide components in Ganoderma lucidum. When the ultrasonic treatment lasts for more than 60 minutes, the increase is more obvious. When the ultrasonic treatment lasts for more than 90 minutes, the increase is not obvious. Therefore, the ultrasonic treatment time is determined to be 60-90 minutes.

[0053] Example 7

[0054] Clean the Ganoderma lucidum fruiting bodies and cut them into thick slices with an average thickness of 3mm, then soak the thick slices with distilled water. Place them in a hot pressure steam cabinet, seal them, evacuate them, pass hot pressure steam, control the pressure in the hot pressure steam cabinet to 125kpa, heat them for 4h, open the vent valve, quickly release the hot pressure steam in the cabinet within 3min, cool them, take out the thick slices of Ganoderma lucidum, place them in an ultrasonic processor for ultrasonic treatment, and the conditions of ultrasonic treatment are: power 250W, frequency 25kHz, time 60min. Then use natural drying, oven drying (65℃, 3h), microwave drying (microwave frequency is 2450MHz, drying temperature is 65℃, drying time is 20min). Determine the content of Ganoderma lucidum polysaccharides and the content of triterpenes and sterols according to the method of the Chinese Pharmacopoeia. The results are shown in the table below.

[0055] Drying method Air dry Oven drying Microwave drying Polysaccharide content (%) 3.58 3.61 4.12 Triterpenes and sterols (%) 0.94 0.91 1.18

[0056] It can be seen from the above table that compared with ordinary oven drying and natural drying, the active ingredient content of Ganoderma lucidum slices after microwave drying is higher.

[0057] Example 8

[0058] Grind the Ganoderma lucidum fruiting bodies into fine powder separately, or use an ultrafine grinder to grind them into ultrafine powder.

[0059] Example 9

[0060] Clean the Ganoderma lucidum fruiting bodies and cut them into thick slices with an average thickness of 3mm, then sprinkle and soak the thick slices with distilled water. Place them in a hot pressure steam cabinet, seal them, evacuate them, pass hot pressure steam, control the pressure in the hot pressure steam cabinet to 125kpa, heat them for 4h, open the vent valve, quickly release the hot pressure steam in the cabinet within 3min, cool them, take out the thick slices of Ganoderma lucidum, place them in an ultrasonic processor for ultrasonic treatment, and the conditions of ultrasonic treatment are: power 250W, frequency 25kHz, time 60min. Then place them in a microwave drying cabinet for drying, the microwave frequency is 2450MHz, the drying temperature is 65℃, and the drying time is 20min. Then crush them into fine powder (pass through an 80-mesh sieve) and crush them into ultrafine powder using an ultrafine grinder.

[0061] The particle size of the powders of Example 8 and Example 9 was tested. The release rate of polysaccharides, triterpenes and sterols (relative to the content in Ganoderma lucidum) after 30 minutes of release was determined according to the second method (paddle method) of the dissolution and release rate determination method of Part IV 0931 of the 2020 edition of the Chinese Pharmacopoeia, and the release liquid was artificial gastric juice. The test results are shown in the table below.

[0062]

[0063] As can be seen from the table above, in Example 9, after the thick slices of Ganoderma lucidum were treated by spraying, hot-pressing steam heating, ultrasonic treatment and microwave drying, not only the content of polysaccharides, triterpenes and sterols was increased, but also the release rate of active ingredients was significantly increased. Whether it is ordinary fine powder or superfine powder, its release rate is much faster than that of Ganoderma lucidum powder of corresponding particle size that has not been treated by the technology of the present invention, which is conducive to improving the effectiveness of Ganoderma lucidum powder for female patients with insomnia.

[0064] The standard of the ganoderma lucidum powder used for female insomnia is determined by testing multiple batches of superfine powder prepared by the technology of the present invention.

[0065] The technology of the present invention increases the content of active ingredients in Ganoderma lucidum by treating Ganoderma lucidum. The reason is not that the technology of the present invention converts other ingredients in Ganoderma lucidum into active ingredients, but that the technology of the present invention destroys the structure of the cell wall of the mycelium of Ganoderma lucidum, making it easy to extract and release the active ingredients originally present in Ganoderma lucidum, so its content increases during measurement. When measuring the content of active ingredients in untreated Ganoderma lucidum, the result of the measurement is lower because the cell wall of the mycelium of Ganoderma lucidum is hard and its ingredients cannot be completely extracted.

[0066] Example 10

[0067] (1) Wash the dried Ganoderma lucidum fruiting bodies with water and cut them into thick slices with an average thickness of 3 mm.

[0068] (2) Spraying the thick slices of Ganoderma lucidum with distilled water to thoroughly moisten them.

[0069] (3) The moistened thick slices of Ganoderma lucidum are placed in a hot-pressed steam cabinet, which is sealed and evacuated, and hot-pressed steam is introduced. The pressure in the hot-pressed steam cabinet is controlled to be 110 kPa, and the heating treatment is performed for 2 hours. Then, the hot steam in the hot-pressed steam cabinet is completely released within 5 minutes, and the hot steam is cooled.

[0070] (4) The heated Ganoderma lucidum thick slices were placed in an ultrasonic processor for ultrasonic treatment at an ultrasonic power of 250 W, a frequency of 25 kHz, and a time of 60 min.

[0071] (5) The ultrasonically treated thick slices of Ganoderma lucidum were placed in a microwave dryer for drying, with the microwave frequency controlled at 2450 MHz, the drying temperature at 60° C., and the drying time at 20 min.

[0072] (6) The dried thick slices of Ganoderma lucidum are placed in an ultrafine grinder and crushed into ultrafine powder to obtain the broken-wall ultrafine Ganoderma lucidum powder for female insomnia.

[0073] Embodiment 11

[0074] (1) Wash the dried Ganoderma lucidum fruiting bodies with water and cut them into thick slices with an average thickness of 3 mm.

[0075] (2) Spraying the thick slices of Ganoderma lucidum with distilled water to moisten them thoroughly.

[0076] (3) The moistened thick slices of Ganoderma lucidum are placed in a hot-pressed steam cabinet, which is sealed and evacuated, and hot-pressed steam is introduced. The pressure in the hot-pressed steam cabinet is controlled to be 110 kPa, and the heating treatment is performed for 2 hours. Then, the hot steam in the hot-pressed steam cabinet is completely released within 5 minutes, and the hot steam is cooled.

[0077] (4) The heated Ganoderma lucidum thick slices were placed in an ultrasonic processor for ultrasonic treatment at an ultrasonic power of 250 W, a frequency of 25 kHz, and a time of 70 min.

[0078] (5) The ultrasonically treated thick slices of Ganoderma lucidum were placed in a microwave dryer for drying, with the microwave frequency controlled at 2450 MHz, the drying temperature at 60° C., and the drying time at 20 min.

[0079] (6) The dried thick slices of Ganoderma lucidum are placed in an ultrafine grinder and crushed into ultrafine powder to obtain the broken-wall ultrafine Ganoderma lucidum powder for female insomnia.

[0080] Example 12

[0081] (1) Wash the dried Ganoderma lucidum fruiting bodies with water and cut them into thick slices with an average thickness of 3 mm.

[0082] (2) Spraying the thick slices of Ganoderma lucidum with distilled water to moisten them thoroughly.

[0083] (3) The soaked thick slices of Ganoderma lucidum are placed in a hot-pressed steam cabinet, which is sealed and evacuated, and hot-pressed steam is introduced. The pressure in the hot-pressed steam cabinet is controlled to be 125 kPa, and the heating treatment is performed for 3 hours. Then, the hot steam in the hot-pressed steam cabinet is completely released within 3 minutes, and the hot steam is cooled.

[0084] (4) The heated Ganoderma lucidum thick slices were placed in an ultrasonic processor for ultrasonic treatment at an ultrasonic power of 250 W, a frequency of 25 kHz, and a time of 70 min.

[0085] (5) The ultrasonically treated thick slices of Ganoderma lucidum were placed in a microwave dryer for drying, with the microwave frequency controlled at 2450 MHz, the drying temperature at 70° C., and the drying time at 20 min.

[0086] (6) The dried thick slices of Ganoderma lucidum are placed in an ultrafine grinder and crushed into ultrafine powder to obtain the broken-wall ultrafine Ganoderma lucidum powder for female insomnia.

[0087] Embodiment 13

[0088] (1) Wash the dried Ganoderma lucidum fruiting bodies with water and cut them into thick slices with an average thickness of 3 mm.

[0089] (2) Spraying the thick slices of Ganoderma lucidum with distilled water to moisten them thoroughly.

[0090] (3) The thick slices of Ganoderma lucidum after being moistened are placed in a hot-pressed steam cabinet, which is sealed and evacuated, and hot-pressed steam is introduced. The pressure in the hot-pressed steam cabinet is controlled to be 125 kPa, and the heating treatment is performed for 4 hours. Then, the hot steam in the hot-pressed steam cabinet is completely released within 3 minutes, and the hot steam is cooled.

[0091] (4) The heated Ganoderma lucidum thick slices were placed in an ultrasonic processor for ultrasonic treatment at an ultrasonic power of 250 W, a frequency of 25 kHz, and a time of 90 min.

[0092] (5) The ultrasonically treated thick slices of Ganoderma lucidum were placed in a microwave dryer for drying, with the microwave frequency controlled at 2450 MHz, the drying temperature at 70° C., and the drying time at 20 min.

[0093] (6) The dried thick slices of Ganoderma lucidum are placed in an ultrafine grinder and crushed into ultrafine powder to obtain the broken-wall ultrafine Ganoderma lucidum powder for female insomnia.

[0094] Comparative Example 1

[0095] (1) Wash the dried Ganoderma lucidum fruiting bodies with water, cut them into thick slices with an average thickness of 3 mm, and dry them in the air.

[0096] (2) The thick slices of Ganoderma lucidum are placed in an ultrafine grinder and crushed into ultrafine powder to obtain ultrafine powder with broken wall of Ganoderma lucidum.

[0097] The test results of the ingredients of Ganoderma lucidum broken wall ultrafine powder are shown in the table below.

[0098]

[0099] As can be seen from the above table, in Examples 10-13, after the thick slices of Ganoderma lucidum were treated by spraying, hot-pressing steam heating, ultrasonic treatment and microwave drying, the contents of extract, polysaccharide, triterpenoid and sterol were significantly higher than those in Comparative Example 1.

[0100] Ganoderma lucidum is a Chinese medicine for both medicine and food announced by the National Health and Family Planning Commission. It can be used as food. For this purpose, the effect of taking Ganoderma lucidum powder was observed on 50 female insomniacs (perimenopausal, 45-55 years old, divided into 5 groups, 10 people in each group, 4 groups took Ganoderma lucidum superfine powder treated with the technology of the present invention, and 1 group took Ganoderma lucidum superfine powder not treated with the technology of the present invention). All 20 people showed insomnia. Medication method: Take with warm water in the morning and evening, 3.0g each time. The control group was Ganoderma lucidum superfine powder not treated with the technology of the present invention. The efficacy judgment criteria are as follows:

[0101] Recovery: Sleep time returns to normal or sleep time at night is more than 6 hours, sleep is deep, and feel refreshed after waking up.

[0102] Significant effect: Sleep is significantly improved, sleep time is increased by more than 3 hours, and sleep depth is increased.

[0103] Effective: Symptoms were alleviated and sleep time increased by less than 3 hours compared to before.

[0104] Ineffective: Insomnia has no significant improvement or worsens after treatment.

[0105] The results are shown in the following table:

[0106] Number of recovered people Number of people with significant effect Effective number of people Invalid number of people Total effective rate (%) Example 10 2 3 4 1 90 Embodiment 11 2 3 5 0 100 Example 12 2 4 4 0 100 Embodiment 13 3 4 3 0 100 Comparative Example 1 0 4 2 4 60

[0107] It can be seen from the table that the Ganoderma lucidum powder processed by the technology of the present invention in Examples 1 to 4 generally has a higher therapeutic effect on female insomnia than the control example.

[0108] The above-described embodiments are compared with the technical solutions and beneficial effects of the present invention, and it should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected.

Claims

1. A method for preparing superfine ganoderma lucidum powder for treating insomnia in women, characterized in that: The preparation method is: (1) Wash the dried Ganoderma lucidum or Ganoderma odoratum fruiting bodies with water and cut them into thick slices; (2) spraying the thick slices of Ganoderma lucidum with distilled water to moisten them thoroughly; (3) placing the thoroughly moistened thick slices of Ganoderma lucidum in a hot-pressed steam cabinet, sealing it, evacuating it, introducing hot-pressed steam, heating it, then releasing the steam, and cooling it; (4) placing the heated Ganoderma lucidum thick slices in an ultrasonic processor for ultrasonic treatment; (5) placing the ultrasonically treated thick slices of Ganoderma lucidum in a microwave dryer for drying; (6) Grinding the dried thick slices of Ganoderma lucidum into ultrafine powder to obtain the broken-wall ultrafine powder of Ganoderma lucidum for treating insomnia in women.

2. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the above (1), the thickness of the Ganoderma lucidum thick slice is 2-4 mm.

3. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the above (2), the soaking time is 12-24 hours.

4. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the step (3), hot press steam is introduced, the pressure in the hot press steam cabinet is controlled to be 105-137 kPa, and the heating treatment time is 2-4 hours.

5. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the above (3), after the heating treatment, the hot steam in the hot pressure steam cabinet is completely released within 2-5 minutes.

6. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the above (4), the conditions for ultrasonic treatment are power 200-300 W, frequency 20-25 kHz, and time 60-90 min.

7. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the above (5), the microwave frequency in the microwave dryer is 2400-2500 MHz, the drying temperature is 60-70° C., and the drying time is 20-30 min.

8. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the above (6), the dried thick slices of Ganoderma lucidum are placed in an ultrafine pulverizer or a jet mill to break the wall and pulverize into ultrafine powder.

9. The method for preparing the broken wall superfine powder of Ganoderma lucidum for treating insomnia in women according to claim 1, characterized in that: In the step (6), the quality requirements for the Ganoderma lucidum wall-broken ultrafine powder include the following: moisture content ≦17%, water-soluble extract ≧3.0%, polysaccharide content ≧2.00%, triterpenoid and sterol content ≧1.0%, 90% of the ultrafine powder particle size in the Ganoderma lucidum wall-broken ultrafine powder ≦30 μm, and no particles exceeding 40 μm are allowed.

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