A traditional Chinese medicine composition for treating chest distress, and a preparation method and application thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating chest stuffiness and a preparation method and application thereof. The traditional Chinese medicine composition for treating chest stuffiness is prepared from the following raw materials in parts by weight: 8-12 parts of Astragalus membranaceus, 3-7 parts of Pueraria lobata, 8-12 parts of Semen Persicae, 3-7 parts of Trichosanthes kirilowii and 3-7 parts of Gardenia jasminoides. The prescription is based on syndrome differentiation, and the prescription is formulated according to the syndrome. The prescription is based on the law, and the prescription is based on the law. Through mutual compatibility of various components, the prescription is based on the law, and the prescription is based on the law. The curative effect is remarkable.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a traditional Chinese medicine composition for treating chest pain, its preparation method, and its application. Background Technology

[0002] In Traditional Chinese Medicine (TCM), chest pain, also known as "sudden heart pain" or "fainting heart pain," is caused by the stagnation of cold and phlegm in the chest, leading to insufficient Yang energy in the chest, or insufficient Qi in the heart, resulting in weak peristalsis, obstruction of Qi and blood, and malnourishment of the heart. Its main manifestation is episodic or persistent chest pain. Because chest pain has a long course, the body's vital energy becomes increasingly deficient over time. The pathogenesis of chest pain is primarily Qi deficiency leading to blood stasis. In other words, the root cause of chest pain is Qi deficiency, while blood stasis and phlegm are its pathological products.

[0003] Chest pain is similar to the symptoms of coronary atherosclerotic heart disease in Western medicine. It refers to a heart disease caused by the blockage or narrowing of the coronary arteries due to atherosclerosis, which leads to myocardial hypoxia or necrosis, and is also known as coronary heart disease or ischemic heart disease. Clinically, this disease is mainly manifested by paroxysmal chest tightness and chest pain in the left chest. In severe cases, it may be accompanied by chest pain radiating to the back and shortness of breath.

[0004] Current treatment methods mainly include surgery and Western medicine. However, long-term use of Western medicine has certain side effects, and surgery is not only invasive but also expensive. Clinical studies have shown that traditional Chinese medicine has significant efficacy in treating cardiovascular diseases, possesses unique advantages and rich experience, and is economical with fewer side effects. Summary of the Invention

[0005] The purpose of this invention is to address the shortcomings of existing technologies by providing a traditional Chinese medicine composition for treating chest pain, its preparation method, and its application. This invention's formulation is based on the principles of etiology and treatment, with the method tailored to the symptoms, ensuring the prescription is grounded in sound medical evidence. Through the synergistic combination of its components, it addresses both the root cause and symptoms, resulting in significant therapeutic effects and providing a superior product for clinically alleviating and curing chest pain.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] The first objective of this invention is to provide a traditional Chinese medicine composition for treating chest pain.

[0008] The second objective of this invention is to provide a method for preparing the above-mentioned traditional Chinese medicine composition for treating chest pain.

[0009] A third objective of this invention is to provide the use of the above-mentioned traditional Chinese medicine composition for treating chest pain.

[0010] To achieve the first objective, the technical solution adopted by this invention is as follows:

[0011] The present application provides a kind of traditional Chinese medicine composition for treating chest pain, the traditional Chinese medicine composition is made of Huangqi, Gegen, Tao Ren, Gualou and Zhizi.

[0012] Further, the traditional Chinese medicine composition for treating chest pain is made of the following raw materials by weight parts: Huangqi 8-12 parts, Gegen 3-7 parts, Tao Ren 8-12 parts, Gualou 3-7 parts and Zhizi 3-7 parts.

[0013] Further, the traditional Chinese medicine composition for treating chest pain is made of the following raw materials by weight parts: Huangqi 8-12 parts, Gegen 3-7 parts, Tao Ren 8-12 parts, Gualou 3-7 parts and Zhizi 3-7 parts.

[0014] Further, the traditional Chinese medicine composition for treating chest pain is made of the following raw materials by weight parts: Huangqi 8-12 parts, Gegen 3-7 parts, Tao Ren 8-12 parts, Gualou 3-7 parts and Zhizi 3-7 parts.

[0015] The traditional Chinese medicine composition of the present application also includes pharmaceutically acceptable excipients, which can include but are not limited to solvents, solubilizers, cosolvents, colorants, disintegrants, fillers, lubricants, wetting agents, stabilizers, flavoring agents, preservatives, suspending agents, coating materials, anti-adhesion agents, integration agents, plasticizers, etc.

[0016] The above weight parts of traditional Chinese medicinal materials are prepared into the traditional Chinese medicine raw materials of the present application, conventional excipients are added according to the conventional method of pharmacy, and various clinically acceptable administration forms are prepared, which include but are not limited to tablets, capsules, oral liquids, oral preparations, granules, instant preparations, pills, drops, powders, pastes, Dan preparations, suspensions, powders, solutions, injections, suppositories, ointments, plasters, creams, sprays, patches, wherein the tablets can be ordinary tablets, sugar-coated tablets, film-coated tablets, and the capsules can be hard capsules or soft capsules.

[0017] Further, the administration form of the traditional Chinese medicine composition for treating chest pain is decoction, granules, tablets, capsules, mixture, syrup, pills, gel, powder or paste.

[0018] To achieve the second object, the technical solution adopted by the present application is as follows: the preparation method of the traditional Chinese medicine composition for treating chest pain is as follows: after the medicinal materials are combined, water is added and decocted twice, the first time is to add water in an amount of 6-8 times the weight of the medicinal materials, decoct for 2-3 h, the second time is to add water in an amount of 6-8 times the weight of the medicinal materials, decoct for 2-3 h, combine the decoction, and reduce pressure to concentrate to an extract with a relative density of 1.05-1.15.

[0019] Further, the preparation method of the present application is as follows: after the medicinal materials are combined, water is added and decocted twice, the first time is to add water in an amount of 6 times the weight of the medicinal materials, decoct for 2 h, the second time is to add water in an amount of 8 times the weight of the medicinal materials, decoct for 3 h, combine the decoction, and reduce pressure to concentrate to an extract with a relative density of 1.10.

[0020] To achieve the third object, the technical scheme adopted by the present application is: the present application provides the use of the traditional Chinese medicine composition for treating chest stuffiness in the preparation of a medicine for preventing or treating chest stuffiness.

[0021] The present application is as follows:

[0022] Radix Astragali: sweet in taste, slightly warm in nature, and belongs to the lung and spleen meridians, and can tonify qi, raise yang, consolidate the exterior to stop sweating, promote water metabolism to relieve edema, produce saliva to nourish blood, remove stagnation to relieve impediment, and help pus discharge and promote healing of sores; it is used for treating deficiency of qi and fatigue, poor appetite and loose stool, middle-qi collapse, chronic diarrhea, prolapse of the rectum, metrorrhagia, hematochezia, self-sweating due to deficiency of qi, edema due to deficiency of qi, internal heat causing diabetes, blood deficiency causing emaciation, hemiplegia, arthralgia and numbness, and ulcer that is difficult to heal.

[0023] Radix Puerariae: sweet and pungent in taste, cool in nature, and belongs to the spleen, stomach and lung meridians, and can relieve the exterior, reduce fever, promote diaphoresis, produce saliva to relieve thirst, raise yang to stop diarrhea, remove obstruction in the channels and activate the collaterals, and relieve alcohol toxicity; it is used for treating external invasion of heat with fever and headache, strong pain in the neck and back, thirst, diabetes, measles without rash, dysentery, dizziness and headache, hemiplegia, chest stuffiness and pain, and alcohol toxicity.

[0024] Semen Persicae: bitter and sweet in taste, and neutral in nature, and belongs to the heart, liver and large intestine meridians, and can activate blood and remove stasis, moisten the intestines and promote defecation, and is used for treating irregular menstruation, blood stasis, postpartum abdominal pain, traumatic injury, and pain due to blood stasis, lung abscess, intestinal abscess and constipation due to dryness of the intestines.

[0025] Fructus Trichosanthis: sweet and slightly bitter in taste, and cold in nature, and belongs to the lung, stomach and large intestine meridians, and can clear heat and reduce phlegm, and is used for treating phlegm-heat cough, chest stuffiness, chest obstruction, lung abscess, intestinal abscess, breast abscess and constipation due to dryness of the intestines.

[0026] Fructus Gardeniae: bitter in taste, and cold in nature, and belongs to the heart, lung and Sanjiao meridians, and can clear away heat and remove dampness, and is used for treating heat disease with restlessness, damp-heat jaundice, blood stasis with pain, blood-heat hematemesis, blood-heat ophthalmalgia, and fire-toxin sores.

[0027] In the present application, Fructus Gardeniae is the monarch drug, and is used for clearing away heat and removing dampness, and for relieving alcohol toxicity, and is used for treating chest stuffiness and true angina; Fructus Trichosanthis and Semen Persicae are used for expanding the chest, activating blood and removing stasis, and assisting the monarch drug; Radix Astragali is used for tonifying qi to treat the root, and Semen Persicae is used for activating blood and removing stasis, and both of them are used for assisting the monarch drug; Fructus Gardeniae is bitter and cold, and belongs to the heart, lung and Sanjiao meridians, and Semen Persicae is bitter and sweet, and belongs to the heart, liver and large intestine meridians, and both of them have the function of transmitting information to the meridians, and the present application has a good curative effect through the mutual compatibility of the components, and the treatment of the root and the branch.

[0028] Compared with the prior art, the present application has the following beneficial effects:

[0029] After the treatment of the traditional Chinese medicine composition, the left ventricular ejection fraction can be significantly improved, and the myocardial infarction caused by cardiac ischemia can be effectively reduced, the cardiac function can be significantly improved, and the development process of chronic heart failure can be successfully intervened.

[0030] The traditional Chinese medicine composition can significantly reduce the frequency and degree of angina pectoris of a patient with angina pectoris, change the ST-T segment state of an electrocardiogram, improve the cardiac ischemia condition, has obvious protection effect on the heart, and has significant clinical effect and is better than similar clinical drugs, thereby providing a better product for relieving and curing the patient with angina pectoris. BRIEF DESCRIPTION OF DRAWINGS

[0031] Figure 1 Comparison of ejection fractions of various groups

[0032] Compared with the normal control group, # P<0.05, ## P<0.01; compared with the model control group, * P<0.05, ** P<0.01; compared with the example 1 group, & P<0.05, && P<0.01.

[0033] Figure 2 Comparison of infarct areas of various groups

[0034] Compared with the normal control group, # P<0.05, ## P<0.01; compared with the model control group, * P<0.05, ** P<0.01; compared with the example 1 group, & P<0.05, && P<0.01.

[0035] Figure 3 Comparison of clinical effects of various groups. DETAILED DESCRIPTION

[0036] The embodiments of the present application will be described in detail below with reference to the examples, but those skilled in the art will understand that the following examples are only used to illustrate the present application, and should not be regarded as limiting the scope of the present application.

[0037] Example 1

[0038] A traditional Chinese medicine composition for preventing or treating angina pectoris is made of the following raw materials: 10 g of Astragalus, 5 g of Pueraria, 10 g of Semen Persicae, 5 g of Trichosanthes and 5 g of Gardenia.

[0039] The medicinal materials are combined, and then boiled with water twice. The first time, 6 times the weight of the medicinal materials is added, and boiled for 2 hours. The second time, 8 times the weight of the medicinal materials is added, and boiled for 3 hours. The decoction is combined, and concentrated under reduced pressure to an extract with a relative density of 1.10.

[0040] Example 2

[0041] A traditional Chinese medicine composition for preventing or treating chest stuffiness is made from the following raw materials: 8g of Huangqi, 7g of Gegen, 8g of Taoren, 7g of Gualou, and 3g of Zhizi.

[0042] The medicinal materials are combined, and then boiled with water twice. The first time, 8 times the weight of the medicinal materials is added, and boiled for 3 hours. The second time, 6 times the weight of the medicinal materials is added, and boiled for 2 hours. The decoction is combined, and concentrated under reduced pressure to an extract with a relative density of 1.15.

[0043] Example 3

[0044] A traditional Chinese medicine composition for preventing or treating chest stuffiness is made from the following raw materials: 12g of Huangqi, 3g of Gegen, 12g of Taoren, 3g of Gualou, and 7g of Zhizi.

[0045] The medicinal materials are combined, and then boiled with water twice. The first time, 7 times the weight of the medicinal materials is added, and boiled for 2.5 hours. The second time, 8 times the weight of the medicinal materials is added, and boiled for 2 hours. The decoction is combined, and concentrated under reduced pressure to an extract with a relative density of 1.05.

[0046] Example 4

[0047] A traditional Chinese medicine composition for preventing or treating chest stuffiness is made from the following raw materials: 10g of Huangqi, 7g of Gegen, 8g of Taoren, 5g of Gualou, and 7g of Zhizi.

[0048] The medicinal materials are combined, and then boiled with water twice. The first time, 8 times the weight of the medicinal materials is added, and boiled for 3 hours. The second time, 6 times the weight of the medicinal materials is added, and boiled for 2 hours. The decoction is combined, and concentrated under reduced pressure to an extract with a relative density of 1.10.

[0049] Example 5

[0050] A traditional Chinese medicine composition for preventing or treating chest stuffiness is made from the following raw materials: 12g of Huangqi, 5g of Gegen, 10g of Taoren, 7g of Gualou, and 3g of Zhizi.

[0051] The medicinal materials are combined, and then boiled with water twice. The first time, 6 times the weight of the medicinal materials is added, and boiled for 2.5 hours. The second time, 6 times the weight of the medicinal materials is added, and boiled for 2.5 hours. The decoction is combined, and concentrated under reduced pressure to an extract with a relative density of 1.15.

[0052] Comparative Example 1

[0053] CN106668386A A kind of for treating acute coronary syndrome caused by spleen deficiency the acute coronary syndrome of phlegm and blood stasis mutual knotting of traditional Chinese medicine preparation in example 1 group party, Huangqi 10g, clear Banxia 6g, Gegen 5g, Tao Ren 10g, Gualou 5g, Zhizi 5g, Lianqiao 10g. According to the preparation method of patent example 1, the decoction prepared by the preparation method is obtained.

[0054] Comparative example 2

[0055] A kind of traditional Chinese medicine composition for preventing or treating chest pain, which is made of Huangqi 10g, Gegen 5g, Tao Ren 15g and Zhizi 5g.

[0056] The preparation method is the same as example 1.

[0057] Comparative example 3

[0058] A kind of traditional Chinese medicine composition for preventing or treating chest pain, which is made of Dangshen 10g, Gegen 5g, Tao Ren 10g, Gualou 5g and Danzhu Ye 5g.

[0059] The preparation method is the same as example 1.

[0060] Pharmacodynamic example The treatment effect of traditional Chinese medicine composition on chronic heart failure rats

[0061] 1. Experimental method

[0062] 56 clean male SD rats, weighing 220±20g, free drinking water and food, the room temperature is kept at 20-25℃. After quarantine for 7 days, 8 were randomly selected as the sham operation group, and the rest were the operation group. Anesthesia was used with 8% chloral hydrate at 5ml / kg intraperitoneal injection, the neck and left chest of rats were shaved, and iodophor was applied. The skin on the neck was opened, bluntly separated, and the trachea was exposed. The trachea was cut between the tracheal rings, and the tracheal tube was inserted. The other end was connected to the breathing machine, and the breathing frequency was adjusted to 70 times per minute, the tidal volume was 10-12ml, and the breathing ratio was 1:1. The skin on the chest was opened, and the ribs were bluntly separated between the 2nd and 3rd ribs. The ribs were opened with a stainless steel prop, the chest cavity was exposed, the thymus was separated, the pericardium was cut, and the heart was lifted out with a self-made steel ring. The needle was inserted with a 6-0 wire suture needle between the lower edge of the left atrial appendage and the pulmonary artery cone, with a depth of about 0.1cm and a width of 0.1-02cm. The heart was reset, and after the rat's heartbeat returned to normal, the knot was tied, the chest cavity was closed, and the chest cavity was lightly pressed to exhaust, and then it was sutured layer by layer. The tracheal tube was pulled out, and the rat's spontaneous breathing was restored. The heart of the sham operation group was not tied with a wire, and the rest of the operation was consistent.

[0063] After 4 weeks of cage breeding, the left ventricular ejection fraction was detected by Doppler ultrasound instrument, and a decrease of 30% or more compared with before modeling was considered successful modeling, and the EF value was randomly divided into groups, and the operation group was divided into model control group, example 1 group, 2 group, comparative example 1 group, 2 group and 3 group, 8 in each group. Each group was given corresponding decoction by gavage, and the dose was 5.6 g / kg. The sham operation group and the model control group were given the same volume of normal saline by gavage. Drug administration was once a day, and drug administration was 4 weeks.

[0064] 2. Sample collection and index detection

[0065] After 4 weeks of administration, the left ventricular ejection fraction was detected by Doppler ultrasound instrument, and the heart was dissected under anesthesia, frozen in a freezer for 30 min, and transversely sectioned along the vertical long axis of the heart. Incubate at 37°C for 20 min with 1% 2,3,5-triphenyltetrazolium chloride (TTC), take a photo, and then use Image J to calculate the infarct area ratio.

[0066] Infarct area ratio = infarct area / left ventricular total area x 100%.

[0067] 3. Statistical method

[0068] Data processing was performed using Graphpad Prism 9.0 software, and measurement data was represented as mean ± standard deviation , one-way ANOVA was used for comparison between multiple groups, SNK-q was used for pairwise comparison between groups, and P<0.05 was considered statistically significant.

[0069] 4. Experimental results

[0070] 4.1 Effect on left ventricular ejection fraction of rats

[0071] Compared with the sham operation group, the left ventricular ejection fraction of the model control group rats was significantly reduced, indicating that the rat heart function was significantly damaged after modeling and was in the disease progression of chronic heart failure. Compared with the model control group, the left ventricular ejection fraction of example 1 group, example 2 group, comparative example 1 group, comparative example 2 group was significantly increased, and example 1 group had the best effect on improving left ventricular ejection fraction and had obvious protective effect on rat heart function. The results are shown in Figure 1 .

[0072] 4.2 Effect on myocardial infarction in rats

[0073] Compared with the sham operation group, the myocardial infarction area of the model control group rats was significantly increased, indicating that the rat myocardium was significantly necrotic after modeling and the cardiac function was severely damaged. Compared with the model control group, the myocardial infarction area of example 1 group, example 2 group, comparative example 1 group, comparative example 2 group was significantly reduced, and example 1 group had the best effect on improving myocardial infarction and had obvious protective effect on rat heart. The results are shown in Figure 2 .

[0074] Compared with the sham operation group, the left ventricular ejection fraction and myocardial infarction area of the model control group rats were significantly changed and lasted for 8 weeks, showing that the rat heart function was obviously damaged and was in the disease process of chronic heart failure. After treatment with the traditional Chinese medicine composition example 1 for 4 weeks, the left ventricular ejection fraction of the rats could be significantly improved, and the myocardial infarction caused by cardiac ischemia could be effectively reduced, the cardiac function could be significantly improved, and the development process of chronic heart failure could be successfully intervened, thereby providing an effective product for alleviating and curing chronic heart failure.

[0075] Clinical observation of the clinical efficacy of the traditional Chinese medicine composition of the present application on patients with chest pain and heart pain

[0076] 1. General information

[0077] 60 patients with chest pain and heart pain in our hospital were selected, who met the diagnostic criteria of coronary heart disease and angina pectoris, had a history of angina pectoris attack, and had ST-T segment elevation in electrocardiogram indicating ischemic changes, and were excluded from patients with major organ organic diseases, underlying diseases and acute myocardial infarction. The patients meeting the above requirements were randomly divided into a control group and a treatment group, with 30 patients in each group. Among them, there were 18 male and 12 female in the control group, 8 cases of spontaneous angina pectoris, 19 cases of labor angina pectoris, 3 cases of post-myocardial infarction angina pectoris, and the average age was (57.1±11.7) years old; there were 20 male and 10 female in the treatment group, 10 cases of spontaneous angina pectoris, 18 cases of labor angina pectoris, 2 cases of post-myocardial infarction angina pectoris, and the average age was (55.6±13.2) years old.

[0078] There was no statistical difference (P>0.05) in the comparison of general information of patients in each group, which was comparable.

[0079] 2. Treatment method

[0080] The patients in the control group orally took compound Danshen tablets, 3 times a day.

[0081] The patients in the treatment group orally took the product of example 1, once in the morning, noon and evening. A course of treatment was 4 weeks.

[0082] 3. Observation index

[0083] Before and after treatment, the scores were compared, and the frequency and degree of angina pectoris were scored as mild, moderate and severe, and the changes in electrocardiogram before and after treatment were recorded. The frequency of angina pectoris was more than 10 times a day for severe, 5-10 times for moderate, and less than 5 times for mild. The cure standard was that the chest pain symptoms basically disappeared and the electrocardiogram ST-T segment returned to normal; the effective standard was that the frequency and degree of chest pain were significantly relieved and the electrocardiogram ST-T segment was significantly improved, and the T wave inversion changed to upright; the effective standard was that the frequency and degree of chest pain were improved and the T wave inversion became shallow; the ineffective standard was that the chest pain symptoms did not improve and the electrocardiogram did not change.

[0084] Total effective rate = (clinical cure + significant effect + effective) number of cases / total number of cases x 100%.

[0085] 4. Statistical method

[0086] SPSS19.0 software was used for data processing, and the obtained data was expressed as Normal distribution test and variance homogeneity test were performed on each group of data, and single factor variance analysis was used for comparison between groups, and P<0.05 was considered to have statistical significance.

[0087] 5. Comparison of clinical efficacy

[0088] Table 1 Comparison of clinical efficacy

[0089] Group Example / Case Total effective rate / % Control group 30 74.1 Treatment group 30 90.3

[0090] From Figure 3 As can be seen from Table 1, the total effective rate of the control group was 74.1%, and the total effective rate of the treatment group was 90.3%, and the clinical efficacy of the treatment group in improving patients with chest pain was significantly better than that of the control group.

[0091] The traditional Chinese medicine composition in the application can significantly reduce the frequency and degree of angina pectoris in patients with chest pain, change the ST-T segment state of electrocardiogram, improve the ischemic condition of the heart, has obvious protective effect on the heart, and has significant clinical effect and is better than similar clinical drugs, and provides a better product for reducing and curing patients with chest pain and heart pain in clinic

[0092] The application has been described in detail above with general description and specific examples, but some modifications or improvements can be made on the basis of the application, which is obvious to those skilled in the art. Therefore, these modifications or improvements made on the basis of not deviating from the spirit of the application, all belong to the scope of the application claimed.

Claims

1. A traditional Chinese medicine composition for treating chest distress, characterized in that, The Chinese medicinal composition for treating chest stuffiness is made of the following raw materials by weight: 8-12 parts of Astragalus, 3-7 parts of Pueraria, 8-12 parts of Semen Persicae, 3-7 parts of Trichosanthes and 3-7 parts of Gardenia.

2. The Chinese medicine composition for treating chest pain according to claim 1, characterized in that, The Chinese medicinal composition for treating chest stuffiness is made of the following raw materials by weight: 10 parts of Astragalus, 5 parts of Pueraria, 10 parts of Semen Persicae, 5 parts of Trichosanthes and 5 parts of Gardenia.

3. The Chinese medicine composition for treating chest pain according to claim 1, characterized in that, The Chinese medicinal composition for treating chest stuffiness is made of the following raw materials by weight: 8 parts of Astragalus, 7 parts of Pueraria, 8 parts of Semen Persicae, 7 parts of Trichosanthes and 3 parts of Gardenia.

4. The traditional Chinese medicine composition for treating chest tightness according to any one of claims 1-3, characterized in that, The Chinese medicinal composition for treating chest stuffiness further comprises pharmaceutically acceptable adjuvants.

5. The traditional Chinese medicine composition for treating chest tightness according to claim 4, characterized in that, The Chinese medicinal composition for treating chest stuffiness is in a clinically acceptable administration form.

6. The traditional Chinese medicine composition for treating chest tightness according to claim 5, characterized in that, The Chinese medicinal composition for treating chest stuffiness is in the form of decoction, granules, tablets, capsules, mixture, syrup, pills, gels, powder or paste.

7. The Chinese medicine composition for treating chest distress according to any one of claims 1-3, characterized in that, The Chinese medicinal composition for treating chest stuffiness is prepared by the following method: the medicinal materials are combined and boiled twice with water, the first time with 6-8 times the weight of the medicinal materials, for 2-3 hours, and the second time with 6-8 times the weight of the medicinal materials, for 2-3 hours, and the decoction is combined and concentrated under reduced pressure to a relative density of 1.05-1.

15.

8. The Chinese medicine composition for treating chest distress according to any one of claims 1-3, characterized in that, The Chinese medicinal composition for treating chest stuffiness is prepared by the following method: the medicinal materials are combined and boiled twice with water, the first time with 6 times the weight of the medicinal materials, for 2 hours, and the second time with 8 times the weight of the medicinal materials, for 3 hours, and the decoction is combined and concentrated under reduced pressure to a relative density of 1.

10.

9. Use of the Chinese medicinal composition for treating chest stuffiness according to any one of claims 1-3 in the preparation of a medicament for preventing or treating chest stuffiness.

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