Traditional Chinese medicine composition for improving simple hepatic cyst as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for improving simple hepatic cyst and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition for improving simple hepatic cyst comprises the following components in parts by weight: 15-25 parts of Chinese yam, 15-25 parts of exocarpium citri grandis, 10-20 parts of fructus crataegi, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of angelica sinensis, 10-20 parts of radix paeoniae alba, 10-20 parts of fructus trichosanthis, 10-20 parts of radix bupleuri, 5-15 parts of salvia miltiorrhiza, 5-15 parts of fructus lycii, 5-15 parts of fructus rosae laevigatae, 5-15 parts of semen ziziphi spinosae, 5-15 parts of codonopsis pilosula and 5-15 parts of semen boitae. , 5-15 parts of chicken's gizzard-membrane and 5-15 parts of cassia twig. The composition has a remarkable effect on improving simple hepatic cyst, materials are safe, and the working capacity of the liver can be comprehensively improved after the composition is continuously taken.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine preparations, and in particular to a Chinese medicine composition for improving simple liver cysts, and a preparation method and application thereof. Background Art

[0002] Liver cysts are a common liver disease, which are divided into simple liver cysts, multicystic liver cysts, and a special type of echinococcosis. Simple cysts are mostly congenital, with unknown causes, and are generally believed to be related to developmental disorders of the intrahepatic bile duct and lymphatic vessels during the embryonic period. Acquired liver cysts have clear causes, such as inflammation, trauma, tumors, etc.

[0003] Simple liver cysts grow slowly and are mostly asymptomatic. They can usually be found in imaging examinations such as B-ultrasound and CT. The incidence rate is between 2.5% and 18%, and it is more common in women. As the cyst continues to grow, it compresses the adjacent organs and can cause symptoms such as fullness after eating, nausea, vomiting, stomach discomfort, and dull pain in the right upper abdomen.

[0004] If the cyst is small and asymptomatic, Western medicine generally does not need to treat it; if the cyst is large and accompanied by symptoms, surgery is the only option.

[0005] TCM believes that liver cysts are caused by liver depression and qi stagnation blocking the spleen and stomach. The spleen is responsible for transporting and transforming water and dampness. The dysfunction of the spleen and stomach will lead to water and dampness stagnation, condensing into phlegm, and forming pathological products. In the long run, pathological products affect the normal operation of qi and blood in the body, causing blood stasis and qi stagnation, forming accumulation of symptoms, and finally forming liver cysts. TCM's prescription ideas for improving liver cysts will consider resolving phlegm and regulating qi, strengthening the spleen and removing dampness, promoting blood circulation and removing blood stasis, and soothing the liver and regulating qi.

[0006] The present invention is based on the theory of traditional Chinese medicine, takes into account the nutritional needs of liver tissue itself, improves the nutritional status of liver cells, strengthens the liver tissue itself, and at the same time improves the liver's own power (self-cleaning ability), absorbs and metabolizes the water in the liver cyst out of the body, in order to improve the liver working ability and health status of patients with liver cysts. Summary of the invention

[0007] The purpose of the present invention is to provide a Chinese medicine composition for improving simple liver cysts, and a preparation method and application thereof, so as to improve the liver working ability and health status of patients with liver cysts.

[0008] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0009] The invention provides a traditional Chinese medicine composition for improving simple liver cysts. The composition comprises the following components in parts by weight: 15-25 parts of yam, 15-25 parts of tangerine peel, 10-20 parts of kojic palm, 10-20 parts of smilax glabra, 10-20 parts of angelica, 10-20 parts of white peony root, 10-20 parts of trichosanthes, 10-20 parts of bupleurum, 5-15 parts of salvia miltiorrhiza, 5-15 parts of wolfberry, 5-15 parts of rosa laevigata, 5-15 parts of spiny jujube seeds, 5-15 parts of codonopsis pilosula, 5-15 parts of cypress seed, 5-15 parts of chicken's gizzard lining and 5-15 parts of cassia twig.

[0010] The present invention also provides a method for preparing the Chinese medicine composition. After the Chinese medicine composition is mixed, water is added and boiled for 1-2 times, and the filtrates are combined to obtain a Chinese medicine preparation.

[0011] Preferably, the decocting time is 20 to 50 minutes.

[0012] Preferably, during the first decoction, the amount of water added is 2 to 3 times the total mass of the traditional Chinese medicine composition, and after the first decoction, the amount of water added is 2 to 3 times the mass of the residue.

[0013] The present invention also provides an application of the Chinese medicine composition or the Chinese medicine preparation obtained by the preparation method in preparing a medicine for improving simple liver cysts.

[0014] The Chinese medicine composition provided by the present invention has a significant effect on improving simple liver cysts, and in the case where some liver cysts are associated with liver nodules and liver hemangiomas, the use of the medicine of the present application can achieve improvement. The liver is a very powerful and complex organ. There are many factors to consider in the maintenance of the liver, and the improvement speed is relatively slow. The material of this prescription is safe, and continuous use can comprehensively improve the working ability of the liver. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is the B-ultrasound image of Chen*fang's liver and gallbladder in Experimental Example 1;

[0016] Figure 2 This is the B-ultrasound image of Chen*fang's liver and gallbladder in Experimental Example 1;

[0017] Figure 3 This is the B-ultrasound image of Li*li's liver in Experimental Example 2;

[0018] Figure 4 This is the B-ultrasound image of Li*li's liver in Experimental Example 2;

[0019] Figure 5 This is the B-ultrasound image of Lin* liver in Experimental Example 3;

[0020] Figure 6 This is the B-ultrasound image of Lin* liver in Experimental Example 3;

[0021] Figure 7This is the B-ultrasound image of Si*Xia's liver in Experimental Example 4;

[0022] Figure 8 This is the B-ultrasound image of Si*Xia's liver in Experimental Example 4;

[0023] Fig. 9 This is the result of abdominal CT scan at week 5 of the experiment;

[0024] Fig.10 This is the B-ultrasound image of the liver in the 5th week of the experiment;

[0025] Fig.11 This is the B-ultrasound image of the liver in the 5th week of the experiment;

[0026] Fig.12 This is the B-ultrasound image of Zhu*Zhu's liver in Experimental Example 6;

[0027] Fig.13 This is the B-ultrasound image of Zhu*zhu's liver in Experimental Example 6. DETAILED DESCRIPTION

[0028] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0029] Example 1

[0030] A traditional Chinese medicine composition for improving simple liver cysts is composed of the following components in parts by weight: 15 parts of yam, 15 parts of tangerine peel, 20 parts of citron, 20 parts of smilax glabra, 10 parts of angelica, 20 parts of white peony root, 10 parts of trichosanthes, 10 parts of bupleurum, 5 parts of salvia miltiorrhiza, 15 parts of wolfberry, 15 parts of rosa laevigata, 15 parts of spiny jujube seeds, 5 parts of codonopsis pilosula, 5 parts of cypress seeds, 15 parts of chicken gizzard lining, and 5 parts of cassia twig.

[0031] After mixing the above raw materials, add water and soak for 50 minutes, the amount of water added is 3 times the weight of the mixed traditional Chinese medicine, decoct after soaking, the decoction time is 50 minutes, separate the solid and liquid, and obtain a filter residue and a first filtrate; add water to the filter residue, the amount of water added is 2 times the weight of the filter residue, continue to decoct for 40 minutes, separate the solid and liquid, and obtain a second filtrate; mix the first filtrate and the second filtrate to obtain a traditional Chinese medicine preparation.

[0032] Example 2

[0033] A traditional Chinese medicine composition for improving simple liver cysts is composed of the following components in parts by weight: 20 parts of yam, 20 parts of tangerine peel, 15 parts of citron, 15 parts of smilax glabra, 15 parts of angelica, 15 parts of white peony root, 15 parts of whole trichosanthes, 15 parts of bupleurum, 10 parts of salvia miltiorrhiza, 10 parts of wolfberry, 10 parts of rosa laevigata, 10 parts of spiny jujube seeds, 10 parts of codonopsis pilosula, 10 parts of cypress seeds, 10 parts of chicken gizzard lining, and 10 parts of cassia twig.

[0034] After mixing the above raw materials, add water and soak for 30 minutes, the amount of water added is 3 times the weight of the mixed traditional Chinese medicine, decoct after soaking, the decoction time is 40 minutes, separate the solid and liquid, and obtain a filter residue and a first filtrate; add water to the filter residue, the amount of water added is 2 times the weight of the filter residue, continue to decoct for 30 minutes, separate the solid and liquid, and obtain a second filtrate; mix the first filtrate and the second filtrate to obtain a traditional Chinese medicine preparation.

[0035] Example 3

[0036] A traditional Chinese medicine composition for improving simple liver cysts is composed of the following components in parts by weight: 25 parts of yam, 25 parts of tangerine peel, 10 parts of citron, 10 parts of smilax glabra, 10 parts of angelica, 10 parts of white peony root, 20 parts of trichosanthes, 20 parts of bupleurum, 15 parts of salvia miltiorrhiza, 10 parts of wolfberry, 5 parts of rosa laevigata, 5 parts of spiny jujube seeds, 5 parts of codonopsis pilosula, 5 parts of cypress seeds, 5 parts of chicken's gizzard lining, and 5 parts of cassia twig.

[0037] After mixing the above raw materials, add water and soak for 40 minutes, the amount of water added is 2 times the weight of the mixed traditional Chinese medicine, decoct after soaking, the decoction time is 50 minutes, separate the solid and liquid, and obtain a filter residue and a first filtrate; add water to the filter residue, the amount of water added is 2 times the weight of the filter residue, continue to decoct for 40 minutes, separate the solid and liquid, and obtain a second filtrate; mix the first filtrate and the second filtrate to obtain a traditional Chinese medicine preparation.

[0038] Experimental Example 1

[0039] Chen*fang, female, 49 years old, has chronic liver disease for many years, is in poor spirits and looks sick. Figure 1 ) showed: the liver was of normal size, the liver capsule was not smooth, the echo was thickened and enhanced, the distribution was uneven, and it showed nodular changes. One of the right liver was about 0.9*0.8cm (liver nodule), with low echo, unclear vascular network, narrow portal vein, and no dilatation of intrahepatic bile duct. Multiple cystic dark areas can be seen in the liver, including one in the left liver with a size of about 1.4*1.1cm (liver cyst), with clear boundaries, and a strong echo spot of about 0.5cm in size (calcification focus) in the right liver. The liver was immediately maintained with the composition of Example 2 of the present invention, and the previous liver-nourishing western medicine and Chinese patent medicine were discontinued. It was taken from February 2024 until October 2024, without interruption, for a total of 8 months, one set a day. The spirit gradually improved, and the complexion improved. The liver and gallbladder B-ultrasound was rechecked in October 2024 ( Figure 2) showed: the liver was normal in size, the liver capsule was not smooth, the echo was thickened and enhanced, the distribution was uneven, and it was nodular. One of the right liver nodules was about 0.5*0.5cm (liver nodule), hypoechoic, the vascular network was not clear, the portal vein was not wide, the intrahepatic bile duct was not dilated, and multiple echo-free areas were seen in the liver, including one of the left liver with a size of about 1.4*1.0cm (liver cyst), with clear boundaries, and a strong echo spot of about 0.4cm in size (calcification focus) was seen in the right liver. After 8 months of systematic maintenance, the comparison of the two liver B-ultrasounds before and after showed that the liver nodules had shrunk by 65%, the liver cysts had shrunk by 9% but not obvious, and the calcification focus had shrunk by 20%. Seeing such comparison results, Ms. Chen and her family felt relieved and continued to insist on maintenance.

[0040] Experimental Example 2

[0041] Li*li, female, 48 years old, business owner, engaged in the beauty industry, has a low daily workload, a regular life, and good eating habits. Her energy decreases with age. She had a comprehensive physical examination in September 2021, including a liver ultrasound ( Figure 3 ) showed that the echo distribution of the liver parenchyma was uneven, and a solid slightly strong echo mass was seen in the right lobe, with clear boundaries and uniform internal echoes, about 4.50*4.98mm in size, which was considered a hemangioma. From September 2021 to February 2022, the prescription of Example 2 of the present invention was taken intermittently for 90 days. In May 2022, the liver was rechecked by B-ultrasound ( Figure 4 ), showing that the liver has no difference in size and shape, the capsule is smooth, the liver area has uniform echo, the liver cyst has been completely reabsorbed and metabolized, and the vascular network is clearly displayed. It can be seen that the liver tissue is well repaired through this patented formula.

[0042] Experimental Example 3

[0043] Lin*, female, 52 years old, a staff member of the procuratorate, has regular exercise and diet, is in good basic physical condition, and is in menopause. She had a comprehensive physical examination in October 2022, including a liver B-ultrasound ( Figure 5 ) showed an anechoic mass in the right liver parenchyma, about 10*8mm in size, with clear boundaries, regular shape, thin and smooth walls, and good internal sound transmission, which was diagnosed as a liver cyst. From January 29, 2023, the patient took the prescription of Example 2 of the present invention for 12 months, with interruptions due to business trips or travel until the end of August 2024. A comprehensive physical examination was conducted in September 2024, including a liver B-ultrasound ( Figure 6 ) shows: the liver is normal in size and shape, the capsule is smooth, the echo of the substance is uniform, the HV is clear, the PV is not wide, the intrahepatic bile duct is not dilated, and there is no solid or liquid mass echo in the liver. It can be seen that the liver cyst has been completely reabsorbed and metabolized.

[0044] Experimental Example 4

[0045] Si*xia, female, retired, has regular physical examinations every year and feels that she is in sub-health. In August 2020, liver B-ultrasound ( Figure 7 ) showed: the liver was normal in size and shape, the light spots were uniform, the vascular network was clear, the portal vein was not wide, and multiple cystic dark areas were seen inside, one of which was about 3.1*2.4cm in size in the right liver. The diagnosis was multiple liver cysts. On August 15, 2020, the prescription of Example 2 of the present invention was started, and it was stopped after three months. It was taken for another month in March 2021 after the Spring Festival. In August 2021, the unit organized a comprehensive physical examination, including liver B-ultrasound ( Figure 8 ) showed that the liver was normal in size and shape, the light spots were uniform, the vascular network was clear, the portal vein was not wide, and multiple cystic dark areas were seen inside, including one in the right liver that was about 3.0*1.9cm in size. The liver cyst was reduced by 23.4%, which shows that the patented formula can repair liver tissue and improve liver cysts.

[0046] Experimental Example 5

[0047] Zhou *Ming, male, 50 years old, had undergone colon cancer surgery. In July 2014, he underwent a full abdominal CT scan + enhanced scan. Fig. 9 ) showed: the liver was normal in size, shape and position, nodular homogeneous cystic low-density shadows were seen in the left lateral liver segment, with smooth edges, no enhancement after enhancement, and a diameter of about 9 mm. The intrahepatic bile duct was not dilated. Nodular low-density nodules with a diameter of about 12 mm were seen in the spleen, with smooth edges, and mild annular enhancement of the lesions after enhanced scanning. It was diagnosed as small nodules in the left lateral liver segment and spleen, with the possibility of metastasis. The patient started taking the prescription of Example 2 of the present invention in April 2015 and took it without interruption until a comprehensive physical examination was performed in July 2017, including liver B-ultrasound ( Fig.10 ) shows that the liver is full in shape and has a smooth capsule. A cystic dark area of ​​about 1.2*1.0 cm is seen in the left liver with clear boundaries. The echo of the remaining parenchyma is finely enhanced, the vascular network is unclear, and the portal vein is not wide. (The spleen is of normal size and the parenchyma has uniform echoes). After that, the prescription of Example 2 of the present invention is taken regularly for 3-6 months each year. Liver B-ultrasound in December 2023 ( Fig.11 ) showed that the liver was full in appearance, the capsule was smooth, the echo of the substance was fine and enhanced, the vascular network was unclear, and the portal vein was not wide. No cyst was detected. It can be seen that through this patented formula, liver tissue can be repaired, and liver nodules and liver cysts can be improved.

[0048] Experimental Example 6

[0049] Zhu*zhu, female, 56 years old, housewife, had thyroidectomy from 2010 to 2015, suffered from mental stress, depression, and poor physical condition. Fig.12) showed: the liver was normal in size and shape, with a smooth capsule. Several cystic dark areas were seen in the right liver with clear boundaries. One of them was about 1.2 cm in diameter with internal septa. The rest of the parenchyma had uniform echoes, clear vascular networks, and a narrow portal vein. In September 2019, the patient continued to take the formula of Example 2 of the present invention. As of March 2021, the liver was reexamined by B-ultrasound ( Fig.13 ) shows: the liver is normal in size and shape, the light spots are thicker and unevenly distributed, the vascular network is clear, the portal vein is not wide, and the intrahepatic bile duct is not dilated. By comparison, it can be seen that the multiple cysts in the right liver have been cleared.

[0050] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for improving simple liver cysts, characterized in that: The invention comprises the following components in parts by weight: 15-25 parts of yam, 15-25 parts of tangerine peel, 10-20 parts of citron, 10-20 parts of smilax glabra, 10-20 parts of angelica, 10-20 parts of white peony root, 10-20 parts of whole trichosanthes, 10-20 parts of bupleurum, 5-15 parts of salvia miltiorrhiza, 5-15 parts of wolfberry, 5-15 parts of rose laevigata, 5-15 parts of spiny jujube seed, 5-15 parts of codonopsis pilosula, 5-15 parts of cypress seed, 5-15 parts of chicken gizzard lining, and 5-15 parts of cassia twig.

2. The method for preparing the Chinese medicine composition according to claim 1, characterized in that: After the Chinese medicine composition is mixed, water is added and boiled for 1-2 times, and the filtrates are combined to obtain a Chinese medicine preparation.

3. The preparation method according to claim 2, characterized in that: The decocting time is 20 to 50 minutes.

4. The preparation method according to claim 2, characterized in that: During the first decoction, the amount of water added is 2 to 3 times the total mass of the traditional Chinese medicine composition. After the first decoction, the amount of water added is 2 to 3 times the mass of the medicinal residue.

5. Use of the Chinese medicine composition according to claim 1 or the Chinese medicine preparation obtained by the preparation method according to any one of claims 2 to 4 in preparing a drug for improving simple liver cysts.

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