Preparation method of antipyretic, analgesic, anti-inflammatory and antiviral Dayuan traditional Chinese medicine and oral liquid thereof

Abstract

The invention discloses an antipyretic, analgesic, anti-inflammatory and antiviral Yuyuan traditional Chinese medicine. The traditional Chinese medicine composition is characterized by being prepared from the following active ingredients in parts by weight: 50-60 parts of betel nuts, 20-30 parts of mangnolia officinalis, 15-20 parts of amomum tsao-ko, 25-30 parts of rhizoma anemarrhenae, 25-30 parts of radix paeoniae alba, 20-30 parts of astragalus membranaceus, 15-20 parts of liquorice, 20-25 parts of semen raphani, 20-25 parts of semen trichosanthis, 15-20 parts of raw fructus aurantii, 20-25 parts of radix bupleuri, 8-10 parts of folium mori, 10-20 parts of fructus forsythiae, 8-10 parts of artemisia apiacea, 5-10 parts of rhizoma menispermi, 10-15 parts of folium isatidis, 8-10 parts of fried coix seeds, 20-22 parts of pericarpium citri reticulatae, 10-15 parts of purslane The Dayuan traditional Chinese medicine has the effects of reducing phlegm and breaking stagnation, regulating qi and clearing damp, repelling foulness and arresting vomiting, clearing heat and nourishing yin, clearing away heat and toxic materials, relieving fever and pain, diminishing inflammation and resisting viruses, and the oral liquid adopts a clarifying agent to replace an alcohol precipitation process, so that the impurity content of an extract is reduced, the content of effective components is improved, the treatment effect is good, and the Dayuan traditional Chinese medicine is convenient to carry by a patient.

Description

Technical Field

[0001] The invention relates to a Dayuanyin Chinese medicine for relieving fever, relieving pain, reducing inflammation and resisting virus and a preparation method of its oral liquid, belonging to the field of Chinese medicine preparations. Background Art

[0002] "Evil hidden in the membrane" is the main pathogenesis theory discussed in "Treatise on Warm Epidemics". Wu Youke created the method of "opening the membrane" and the prescription of "Dayuanyin" based on this theory. Wu Youke believed that the meridians of typhoid fever entered the interior from the exterior, and the warm epidemic qi entered from the mouth and nose. At the beginning, the evil was hidden in the membrane, between the exterior and the interior. Dayuanyin was created to dredge the membrane and disperse the evil qi. After the evil qi is dispersed, it may come out of the exterior, cross the three meridians, and sweat; it may also reach the interior and pass to the stomach, which can be relieved by going down. There may be two situations in the late stage of warm epidemics: smooth and adverse. In the smooth case, the exterior and interior qi are connected, and the interior evil is removed by going down. The exterior evil may be relieved by sweating or by the appearance of rashes. In the adverse case, the treatment should be based on the situation of the deficiency and excess of the evil. Wu Youke emphasized the three major taboos in treatment, that is, do not use qi-breaking drugs, do not use tonics, and do not use cold and cool drugs. As mentioned above, Dayuanyin is designed for the filthy and turbid evil of warm epidemics hiding in the membrane source. When the warm epidemic evil enters the membrane source half on the surface and half on the interior, the evil and the good fight each other, so there is aversion to cold and high fever; the warm evil and the toxicity invade the interior, causing nausea, headache, irritability, thick white tongue coating like accumulated powder and other filthy and turbid symptoms. At this time, the evil is not on the surface, so it is forbidden to use sweating; there is dampness in the heat, so it is not possible to simply clear the heat; there is heat in the dampness, so it is forbidden to dry the dampness unilaterally. The method should be to open the membrane source and eliminate the filth and turbidity.

[0003] In the Qing Dynasty, Ye Tianshi and Xue Shengbai believed that the evil hidden in the membrane was the evil of dampness and heat blocking the qi, causing the qi of the exterior and interior, and the upper and lower parts to be blocked. Shao Xuehong believed that the membrane was similar to the abdominal connective tissue in anatomy. Dong Jianjun divided the structure of the gaps between the skin, flesh, veins, tendons, and bones into five levels from shallow to deep, corresponding to the qi of the five elements and five internal organs. The membranes of the five bodies are collectively called "five membranes", which are the parts that need to be acupunctured during acupuncture treatment. Gao Jiajun believed that the membrane was a membranous tissue system that was interconnected and widely distributed between the body, internal organs, flesh, chest and abdomen, and skin, and the gaps between them. Su Yunfang's system membrane theory believed that the three-dimensional space of the human body implicitly concealed the functional levels of the membrane, and proposed a hypothesis of nine functional intervals of the human body system membrane. Gao Zhongying believed that the evil hidden in the membrane refers to the evil of temperature hiding in the membrane, which not only involves the diaphragm of the upper Jiao, but also the stomach and intestines of the middle Jiao, emphasizing that although the evil has left the surface, it has not yet entered the internal organs. Gao Jianzhong believes that the Treatise on Warm Epidemics points out that: "When the pathogenic pathogens spread through the meridians, they should be used according to the meridians to help ascend and drain..." "If there are symptoms of Sanyang, use Dayuanyin Sanyang plus method. Because there are symptoms of internal diseases, add rhubarb, named Sanxiaoyin. Sanxiao means to eliminate internal diseases, eliminate external diseases, and eliminate neither internal nor external diseases." In other words, Dayuanyin is specially designed for "eliminating neither internal nor external diseases". As long as there is pathogenic pathogens in "neither internal nor external diseases", regardless of the course of the disease, Dayuanyin plus or minus treatment can be used. Tang Limeng believes that what Wu Youke called the membrane source is not simply the fascia tissue outside the stomach, but is centered on the stomach and intestines, dividing the stomach meridian, connecting with the slow tendons in front and the back to the tendons.

[0004] Wang Yuguang and his colleagues went deep into the clinical frontline and, through observing more than 100 patients, initially proposed the etiology, pathogenesis, and treatment principles of this disease in traditional Chinese medicine. They believed that dampness, toxicity, and epidemic evil were the main causes of this disease. From the perspective of traditional Chinese medicine syndromes, dampness and toxicity were the core pathogenesis. Dampness and toxicity accumulated heat and transformed into heat, which led to lung and intestine diseases, and then spread to the pericardium and manifested as critical illness. Early stage: Dampness and toxins accumulate in the lungs, and the pivotal organs are not in good condition. Dayuanyin is recommended. Zong Yang and others used the Traditional Chinese Medicine Systems Pharmacology Analysis Platform (TCMSP) to retrieve the chemical components and targets of Dayuanyin, indicating that the active compounds in Dayuanyin can regulate multiple signaling pathways by combining with angiotensin-converting enzyme II (ACE2) to act on targets such as PTGS2, HSP90AA1, and ESR1, thereby potentially having a therapeutic effect on pneumonia. Wang Li used tail vein injection to create an ALI model in rats to study the effects of different antipyretic prescriptions on acute lung injury in rats. The results showed that Dayuanyin can reduce the synthesis and secretion of ET-1 and NO in the blood and lung tissues, and can inhibit the expression of NF-кB in the bronchi and lung tissues, thereby alleviating lung damage.

[0005] Traditional Dayuan medicines are generally prepared in decoction form. Decoctions are ingested into the human body in liquid form, which is easy to absorb and has a quick onset of effect. However, decoctions are not easy to carry, not easy to store for a long time, and have a low concentration of effective drug ingredients. When it is made into capsules, the volume of the drug extract is too large. To achieve the expected therapeutic effect, a large number of capsules need to be taken, and the drug enters the human body in solid form, which has a relatively slow onset of effect. When preparing granules, the drug extract is too viscous and the granules are not easy to form. Combining modern extraction and preparation processes, people have developed Dayuan Yinwei Floating Tablets to improve the problem of inconvenience in carrying. However, the release rate of drug ingredients in tablets is lower than that of liquid preparations, and the onset of effect is slower, which is not conducive to rapid control of the disease at the beginning of the epidemic.

[0006] The profound and extensive Chinese medicine culture relies on the rich soil of traditional Chinese culture. The ideas and methods of the vast number of medical professionals to understand life, maintain health, and prevent and treat diseases have formed a brilliant Chinese medicine culture. With people's continuous research and development, there will inevitably be the emergence of Dayuanyin Chinese medicine with better therapeutic effects, easy to carry, antipyretic, analgesic, anti-inflammatory and antiviral effects, which will bring good news to patients. Summary of the invention

[0007] The technical problem to be solved by the present invention is to provide a Dayuanyin Chinese medicine for relieving fever, relieving pain, reducing inflammation and resisting virus, which has good therapeutic effect, no toxic side effects and is convenient to carry, and a preparation method of the oral liquid thereof.

[0008] The technical solution adopted by the present invention to solve the technical problem is: The invention discloses a Dayuanyin Chinese medicine for relieving fever, relieving pain, reducing inflammation and resisting virus. The raw materials for making the effective ingredients of the Chinese medicine are as follows: 50-60 parts of betel nut, 20-30 parts of magnolia bark, 15-20 parts of tsaoko, 25-30 parts of rhizoma anemarrhenae, 25-30 parts of white peony root, 20-30 parts of astragalus, 15-20 parts of liquorice, 20-25 parts of radish seed, 20-25 parts of trichosanthes seed, 15-20 parts of raw aurantium, 20-25 parts of bupleurum, 8-10 parts of mulberry leaf, 10-20 parts of forsythia, 8-10 parts of artemisia annua, 5-10 parts of northern bean root, 10-15 parts of isatis indigotica, 8-10 parts of stir-fried coix seed, 20-22 parts of dried tangerine peel, 10-15 parts of purslane, 10-20 parts of rhubarb and 10-15 parts of jujube.

[0009] Preferably, the antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin Chinese medicine is made of the following raw materials for its effective ingredients, in parts by weight: 60 parts of betel nut, 30 parts of magnolia bark, 15 parts of tsaoko, 30 parts of rhubarb, 30 parts of white peony root, 30 parts of astragalus, 15 parts of licorice, 20 parts of radish seeds, 20 parts of trichosanthes seeds, 15 parts of raw aurantium, 20 parts of bupleurum, 10 parts of mulberry leaves, 10 parts of forsythia, 10 parts of artemisia annua, 5 parts of northern bean root, 10 parts of isatis indigotica, 10 parts of stir-fried coix seeds, 20 parts of tangerine peel, 10 parts of purslane, 15 parts of rhubarb, and 15 parts of jujube.

[0010] The above 21 raw materials are all active ingredients after drying.

[0011] The Dayuanyin Chinese medicine is in the form of powder, extract or oral liquid.

[0012] The preparation method of the above-mentioned antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin oral liquid comprises the following specific steps: ① Weigh the above raw materials according to the ratio, mix well, add 4 to 5 times the amount of drinking water, soak for 45 to 60 minutes, heat and boil for 75 to 90 minutes, filter while hot to obtain residue A and decoction A; ② Add 3 to 4 times the amount of drinking water as the raw material to the residue A, boil for 45 to 60 minutes, filter while hot, and obtain the residue B and decoction B; ③ Add 1 to 2 times the amount of drinking water as the raw material to the residue B, boil for 30 to 45 minutes, filter while hot, and obtain residue C and decoction C; ④ Combine decoction A, decoction B and decoction C, let stand for 6 to 10 hours, pass the supernatant through a 200-mesh sieve, and obtain filtrate A for later use; ⑤ The filtrate A is concentrated by heating in a negative pressure evaporator until the ratio of the mass of the medicinal material to the volume of the decoction is 1: (1.2-1.5); ⑥ After concentration, add an appropriate amount of clarifier, stir for 25 to 40 minutes, let stand for 2 to 5 hours, filter, and obtain filtrate B for standby use; ⑦ Add an appropriate amount of flavoring agent to filtrate B, stir for 25 to 40 minutes, let stand for 2 to 3 hours, filter, and pass the supernatant through a 200-mesh sieve to obtain filtrate C for standby use; ⑧ Boil an appropriate amount of drinking water, cool it to room temperature, add it to the filtrate C to make the total amount of liquid medicine, and adjust the Ph to 6.0-6.5; ⑨ After stirring, the mixture is allowed to stand for 1 to 2 hours. After passing the inspection, the mixture is centrifuged at high speed, sealed, and sterilized to obtain the prepared antipyretic, analgesic, anti-inflammatory, and antiviral oral liquid.

[0013] In step ⑥, the clarifier is a chitosan flocculation clarifier, and the amount of the clarifier added is 1% to 2% of the volume of the drug solution.

[0014] In step ⑦, the flavoring agent is mogroside sweetener, and the added amount is 1.5% to 2% of the mass of filtrate B.

[0015] In the antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin Chinese medicine of the present invention, the pharmacological effects of each raw material medicine are as follows: Betel nut: It has the effects of killing insects and removing accumulations, promoting qi and promoting diuresis, dispersing dampness, resolving phlegm and breaking up lumps, and quickly eliminating evil.

[0016] Magnolia officinalis: bitter, flat and warm in taste, it belongs to the spleen, kidney, lung and large intestine meridians. It has the effects of drying dampness and eliminating phlegm, relieving gas and asthma, eliminating accumulation and relieving stagnation. It can effectively treat constipation and symptoms such as phlegm stagnation.

[0017] Amomum villosum: It tastes spicy and warm, and belongs to the spleen and stomach meridians. It has the effects of drying dampness and dispersing cold, removing phlegm and stopping malaria. It is mainly used to treat chest and diaphragm fullness, cold pain in the abdomen, nausea and vomiting, diarrhea, food stagnation, cholera, plague, malaria and other symptoms.

[0018] Anemarrhena: bitter and sweet in taste, cold in nature, enters the lung, stomach and kidney meridians. It has the effects of nourishing yin and moistening dryness, clearing the lungs and resolving phlegm, promoting fluid and quenching thirst, relieving constipation and moistening dryness, nourishing yin and reducing fire.

[0019] White Peony Root: Bitter and sour in nature, slightly cold, enters the liver and spleen meridians. It has the effects of calming the liver and relieving pain, nourishing blood and regulating menstruation, astringing yin and stopping sweating, softening the liver and relieving pain.

[0020] Scutellaria baicalensis: It is bitter and cold in nature, and enters the lung, gallbladder, spleen, large intestine and small intestine meridians. It has the effect of clearing heat and drying dampness. It is suitable for symptoms such as damp-heat, summer dampness, chest tightness and nausea, damp-heat fullness, jaundice and diarrhea.

[0021] Licorice: It is mild in nature, sweet in taste, and enters the heart, lung, spleen, and stomach meridians. It is a kind of qi-invigorating medicine, which has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain, and harmonizing various medicines.

[0022] Radish seeds: spicy, sweet, neutral in nature. Enter the lung, spleen, and stomach meridians, have the effects of digesting food and eliminating bloating, lowering qi and resolving phlegm, and are used for symptoms such as food stagnation, abdominal distension and pain, constipation, stagnation of stool, diarrhea, phlegm congestion, wheezing and coughing.

[0023] Trichosanthes fruit: sweet in taste, cold in nature, enters the lung, stomach, and large intestine meridians, has the effects of moistening the lungs and resolving phlegm, relieving chest congestion and dispersing stagnation, moistening the intestines and promoting bowel movements, reducing swelling and discharging pus.

[0024] Raw Citrus aurantium: tastes bitter, pungent and cold, and belongs to the spleen, stomach and liver meridians. It has the effects of breaking up qi, removing phlegm and eliminating accumulation. It is used to treat symptoms such as distension and pain in the ribs, indigestion, abdominal distension, and heaviness after diarrhea.

[0025] Bupleurum: bitter in taste, slightly cold, enters the liver and gallbladder meridians, has the effects of reconciling the exterior and interior, soothing the liver, and raising yang, and is used for symptoms such as colds and fever, alternating chills and heat, and distension and pain in the chest and flanks.

[0026] Mulberry leaf: sweet, bitter, cold in nature, enters the lung and liver meridians. Efficacy: dissipates wind-heat, clears the lungs and moistens dryness, calms liver yang, clears the liver and improves eyesight, cools blood and stops bleeding.

[0027] Forsythia: bitter in taste, slightly cold in nature, and enters the lung and heart meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules, and treating wind-heat colds. It is mainly used to treat symptoms such as febrile diseases, heat stranguria and urinary retention, carbuncles, swelling and toxins, scrofula, goiter, and throat paralysis.

[0028] Artemisia annua: It is cold in nature, bitter and pungent in taste, and enters the liver and gallbladder meridians. It has the effects of clearing away heat, relieving summer heat, eliminating steaming, and stopping malaria. It is mainly used to treat symptoms such as fever due to summer heat, night fever due to yin deficiency, bone steaming and fatigue fever, malaria cold and heat, and damp-heat jaundice.

[0029] Northern bean root: bitter in taste and cold in nature, it has the effects of clearing away heat and detoxifying, promoting dampness and reducing swelling. It is mainly used to treat symptoms such as sore throat, lung heat cough, tonsillitis, and chronic bronchitis.

[0030] Folium Isatidis: bitter in taste, cold in nature, enters the heart, liver, spleen, and stomach meridians, has the effects of clearing away heat and detoxifying, cooling blood, removing spots, and relieving sore throat. It is mainly used to treat fever, headache, sore throat, rashes, mumps, carbuncles, and sores caused by febrile diseases.

[0031] Fried Job's tears: sweet in nature, light in taste, and relatively mild. It belongs to the spleen meridian, stomach meridian, and lung meridian. It has the effects of promoting diuresis and eliminating dampness, strengthening the spleen and stopping diarrhea, dispersing depression, relaxing muscles and removing numbness, clearing away heat and discharging pus.

[0032] Tangerine peel: Spicy and bitter in taste, warm in nature, and enters the spleen and lung meridians. It has the effects of regulating qi and appetizing, drying dampness and resolving phlegm, and is used to treat symptoms such as chest and abdominal distension, loss of appetite and vomiting, and cough with excessive phlegm.

[0033] Purslane: cold in nature, sour in taste, enters the heart, liver, spleen, and large intestine meridians, and has the effects of clearing away heat and detoxifying, promoting diuresis and removing dampness, dispersing blood and reducing swelling, and relieving inflammation and pain. It is mainly used clinically to treat symptoms such as heat dysentery, damp-heat bacillary dysentery, sores, and fire-toxic furuncles.

[0034] Rhubarb: It is cold in nature, bitter in taste, and enters the spleen, stomach, large intestine, liver, and pericardium meridians; it has the effects of purging accumulation, clearing away heat and purging fire, cooling blood and detoxifying, removing blood stasis and dredging menstruation, and promoting bile secretion and relieving jaundice.

[0035] Jujube: warm in nature, sweet in taste, enters the spleen, stomach, and heart meridians, and belongs to the category of Qi-tonifying medicine. It has the effects of nourishing and harmonizing the middle, and can be used to reconcile the properties of medicines and reduce the toxic side effects of drugs.

[0036] The positive beneficial effects of the present invention are as follows: 1. The present invention adopts the classic prescription of Dayuanyin (areca nut, magnolia bark, tsaoko, anemarrhena, white peony root, astragalus, licorice), and adds radish seed, trichosanthes seed, raw aurantium, bupleurum, mulberry leaf, forsythia, artemisia annua, northern bean root, isatis indigotica, stir-fried coix seed, tangerine peel, purslane, rhubarb, jujube and other Chinese medicinal materials, and is refined by a unique processing and extraction process. It has the effects of resolving phlegm and breaking up knots, regulating qi and removing dampness, eliminating filth and stopping vomiting, clearing heat and nourishing yin, eliminating filth and clearing turbidity, clearing away heat and detoxifying, relieving fever and analgesia, and anti-inflammatory and antiviral.

[0037] 2. The present invention limits the soaking time of medicinal materials, the amount of water added, the number of extractions, the extraction time, the concentration temperature, the selection and addition amount of auxiliary materials, the specific gravity of the medicinal solution, etc., and has a standardized preparation process. It can provide a standardized oral liquid preparation, the product has accurate dosage, stable quality, is easy to take, is suitable for large-scale commercial production, and is convenient for patients to carry and take.

[0038] 3. The preparation process of oral liquid in the prior art mostly adopts a simple water extraction and alcohol precipitation method, and the extract contains many impurities, the extraction efficiency is low, and the content of effective ingredients in the extract is low, so the preparation process needs to be further improved. The present invention improves the conditions in the preparation process of oral liquid, replaces the alcohol precipitation process in the traditional method with a clarifier, so that the impurity content of the extract is reduced, the content of effective ingredients is increased, and the quality of the oral liquid is controlled by different contents of effective ingredients, thereby improving the clinical efficacy.

[0039] 1.1 Effect of xylene on ear swelling in mice: Methods: 50 SPF ICR male mice were randomly divided into model control group, positive control group (aspirin, 0.2 g / kg), low-dose (3.50 g / kg), medium-dose (7.00 g / kg) and high-dose (14.00 g / kg) groups according to body weight. The drug was administered by gavage once a day for 7 consecutive days, with a dosing volume of 0.2 ml / 10 g. 60 minutes after the last administration, 30 ul of xylene was applied to the inner and outer surfaces of the right auricle of the mice to induce inflammation. 30 minutes after inflammation, the mice were killed by dislocation, and the ear pieces were removed from the left and right ears symmetrically with a 9 mm diameter puncher, and weighed on an analytical balance. The weight difference between the left and right ear pieces was taken as the degree of swelling.

[0040] Ear swelling results

[0041] Note: ** P ﹤0.01, compared with the model control group.

[0042] Conclusion: The Dayuanyin Chinese medicine of the present invention has a certain anti-inflammatory effect on xylene-induced ear inflammation in mice at 14.00 g crude drug / kg.

[0043] 1.2 Effects of carrageenan on plantar swelling in rats: Methods: Fifty male rats were divided into model control group, positive control group (dexamethasone acetate, 2.0 mg / kg), low (1.75 g / kg), medium (3.50 g / kg), and high (7.00 g / kg) dose groups, 10 rats / sex / group. The rats were given intragastric administration once a day for 7 consecutive days, with a dosing volume of 1.0 ml / 100 g. 1.5 h after the last administration, 0.1 ml / rat of 1% carrageenan was injected subcutaneously into the plantar of the left hind paw of the rats to induce inflammation. The plantar volume of each group was measured before inflammation, 1, 2, and 3 h after inflammation using a toe volume meter, and the plantar swelling value (the difference between the volume after inflammation and the volume before inflammation) was calculated.

[0044] Statistical results of plantar swelling

[0045] Note: * P <0.05, ** P ﹤0.01, compared with the model control group.

[0046] Conclusion: According to the statistics of this experiment, Dayuanyin Chinese medicine has a significant anti-inflammatory effect on carrageenan-induced plantar swelling in rats at a dose of 3.50-7.00 g / kg.

[0047] 1.3 Analgesic effect on mice (writhing method): Methods: 50 SPF ICR mice, half male and half female, were randomly divided into model control group, positive control group (aspirin, 0.2 g / kg), low-dose (3.50 g / kg), medium-dose (7.00 g / kg) and high-dose (14.00 g / kg) groups according to body weight. The mice were given intragastric administration once a day for 7 consecutive days, with a volume of 0.2 ml / 10 g. 1.5 hours after the last administration, 0.6% glacial acetic acid 0.2 ml / 20 g was injected intraperitoneally, and the number of writhing times of mice in each group within 15 minutes was recorded immediately after the intraperitoneal injection of 0.6% glacial acetic acid.

[0048] Twist times result table

[0049] Note: ** P ﹤0.01, compared with the model control group.

[0050] Conclusion: The test sample has a certain analgesic effect on abdominal pain (writhing reaction) induced by 0.6% glacial acetic acid when the concentration range is 7.00-14.00 g crude drug / kg.

[0051] 1.4 Analgesic effect on mice (hot plate method): Methods: 50 SPF ICR female mice were randomly divided into model control group, positive control group (indomethacin, 5 mg / kg), low-dose (3.50 g / kg), medium-dose (7.00 g / kg) and high-dose (14.00 g / kg) groups according to body weight. The drug was administered by gavage once a day for 7 consecutive days, with a dosing volume of 0.2 ml / 10 g. 90 minutes after the last administration, the mice were placed in a hot plate instrument, and the pain threshold of each group of mice was measured.

[0052] Pain threshold structure record table

[0053] Note: ** P ﹤0.01, compared with the model control group.

[0054] Conclusion: The test sample, at a concentration of 7.00-14.00 g crude drug / kg, had a certain analgesic effect on the pain induced by hot plate (55°C) in mice.

[0055] 1.5 Effect on the body temperature of the endotoxin (lipopolysaccharide)-induced fever rabbit model: Methods: Thirty rabbits with body temperature in the range of 38.0-39.5℃ and daily fluctuation of no more than 0.4℃ were selected and divided into five groups according to the normal value of body temperature measured on the day of the experiment, namely, model control group, acetaminophen positive control group (0.2g / kg), Dayuanyin Chinese medicine: low (1.05g crude drug / kg), medium (2.10g crude drug / kg), and high (4.20g crude drug / kg) dose groups, with 6 rabbits in each group, half male and half female. The rabbits were given intragastrically once, and the administration volume was 3 ml / kg. Thirty minutes after the administration, lipopolysaccharide (0.2 ug / kg) was injected into the ear vein of the rabbits to establish the model. After the administration, the body temperature was measured once every 1 hour, for a total of 5 times, and the changes in body temperature at different times after the fever were measured.

[0056] Effects on lipopolysaccharide-induced fever in rabbits (X±SD, n=6)

[0057] Note: Compared with the model control group, *P<0.05, ** P<0.01 Conclusion: The test sample was between 2.10 and 4.20 g crude drug / kg. The Dayuanyin Chinese medicine of the present invention had a certain tendency to reduce the temperature of the febrile rabbits caused by endotoxin (lipopolysaccharide).

[0058] 1.6 Effects on yeast-induced fever in rats: Methods: The rats that passed the quarantine had their basal body temperature measured twice a day 2 days before the experiment. Fifty normal rats with a body temperature of 37.0-39.0 ℃ were selected, half of which were male and half were female. They were arranged in the order of body temperature and divided into model control group, positive drug control group (acetaminophen 0.166 g / kg), test sample low (1.75 g / kg), medium (3.50 g / kg), and high (7.00 g / kg) dose groups according to the Latin square grouping method, 5 rats / group / sex. 5h before administration, rats were subcutaneously injected with 20% yeast suspension to establish the model. The body temperature was measured once at 0h, 1h, 2h, 3h, 4h, and 5h after administration.

[0059] Effects of Dayuanyin Chinese medicine on yeast-induced fever in rats (℃, X±S, n=10)

[0060] Note: Statistically significant comparisons. * : P <0.01 Conclusion: Dayuanyin (extract) has a certain cooling trend in yeast-induced fever rats within the dosage range of 1.75-7.0 g crude drug / kg. 2.1.1 Methods

[0061] The maximum dose method was used for single-dose toxicity test. 40 SPF SD rats were taken, half male and half female, and divided into 2 groups according to body weight, a solvent control group and a test group, with 20 rats in each group. The drug was administered orally twice within 24 hours, with a volume of 20 ml / kg. The toxicity of the animals was observed after the drug administration, and the observation was continued for 14 days. The animals were weighed at the time of administration and on the 1st, 3rd, 5th, 7th, 9th, and 14th days after the drug administration. All rats were dissected after the death of animals and the survival observation was completed to observe the position, shape, size, color, texture of each organ, and the presence of secretions (or exudates), congestion, bleeding, edema, necrosis and other changes.

[0062] 2.1.2 Results 2.1.2.1 General signs Test group: After administration, the subjects showed symptoms such as decreased activity, black stool, and dark yellow urine, which basically disappeared after 2 to 3 days. Vehicle control group: No obvious abnormality was observed.

[0063] 2.1.2.2 Body weight changes: The surviving animals gained weight well. There was no significant statistical difference in body weight between the test article group and the vehicle control group.

[0064] 2.1.2.3 Gross autopsy: All animals were subjected to gross autopsy, which revealed that the gastric mucosa was intact without bleeding or erosion. Macroscopic observation of the heart, liver, spleen, lungs, and kidneys showed that the texture and color of the main organs were normal, without swelling, adhesion, congestion, or abnormal pathological histological changes.

[0065] 2.1.3 Conclusion 2.1.3.1 After administration, the rats showed symptoms such as decreased activity, black stool, and dark yellow urine, which disappeared after 2 to 3 days. No obvious pathological changes were observed by gross autopsy. 2.1.3.2 The surviving animals in the drug-treated group recovered to normal after 2 to 3 days and gained weight well.

[0066] Through observations of general physical signs, mortality, weight changes and other indicators, Dayuanyin (extract) failed to cause obvious acute toxic reactions.

[0067] 2.2.1 Methods The maximum dose method was used for single-dose toxicity test. 40 SPF SD rats were taken, half male and half female, and divided into 2 groups according to body weight, a solvent control group and a test group, with 20 rats in each group. The drug was administered orally twice within 24 hours, with a volume of 20 ml / kg. The toxicity of the animals was observed after the drug administration, and the observation was continued for 14 days. The animals were weighed at the time of administration and on the 1st, 3rd, 5th, 7th, 9th, and 14th days after the drug administration. All rats were dissected after the death of animals and the survival observation was completed to observe the position, shape, size, color, texture of each organ, and the presence of secretions (or exudates), congestion, bleeding, edema, necrosis and other changes.

[0068] 2.2.2 Results 2.2.2.1. General signs Test group: After administration, the subjects showed symptoms such as decreased activity, black stool, and dark yellow urine, which basically disappeared after 2 to 3 days. Vehicle control group: No obvious abnormality was observed.

[0069] 2.2.2.2 Body weight changes: The surviving animals gained weight well. There was no significant statistical difference in body weight between the test group and the vehicle control group.

[0070] 2.2.2.3 Gross autopsy: All animals underwent gross autopsy, which revealed that the gastric mucosa was intact without bleeding or erosion. Macroscopic observation of the heart, liver, spleen, lungs, and kidneys showed normal texture and color without swelling, adhesion, congestion, or abnormal pathological histological changes.

[0071] 2.2.3 Conclusion 2.2.3.1 After administration, the rats showed symptoms such as decreased activity, black stool, and dark yellow urine, which disappeared after 2 to 3 days. No obvious pathological changes were observed by gross autopsy. 2.2.3.2 The surviving animals in the drug-treated group recovered to normal after 2 to 3 days and gained weight well.

[0072] Through observations of general physical signs, mortality, weight changes and other indicators, Dayuanyin (extract) failed to cause obvious acute toxic reactions.

[0073] 2.3.1 Test methods A total of 120 rats that passed the quarantine were selected, half male and half female, and divided into 4 groups, namely solvent control group (distilled water), test sample Dayuanyin (extract) low (6.45 g crude drug / kg), medium (19.35 g crude drug / kg), and high (64.50 g crude drug / kg) dose groups, 15 rats / sex / group, and the drugs were administered by gavage once a day for 28 consecutive days, followed by 28 days of recovery after drug withdrawal.

[0074] General physical signs were observed every day, body weight and food intake were measured once a week, and autopsies were performed at the end of the dosing period (10 mice / sex / group) and the end of the recovery period (5 mice / sex / group), and hematology, blood biochemistry, urine routine tests, etc. were performed. The main organs were weighed, the organ coefficients were calculated, and histopathological examinations were performed.

[0075] 2.3.2 Test results 2.3.2.1 General signs 24 hours after administration, animals in the low-dose, medium-dose and high-dose groups all showed symptoms of colored urine and drug-colored feces, and animals in the high-dose group showed reduced activity, which lasted throughout the administration period. 48 hours after drug withdrawal, animals in each dose group returned to normal.

[0076] 2.3.2.2 Weight During the drug administration period: the body weight of animals in each group increased well, and there was no statistical significance between the drug administration groups and the vehicle control group (P>0.05).

[0077] During the recovery period: there was no statistically significant difference between the various dosage groups and the vehicle control group (P>0.05).

[0078] 2.3.2.3 Food intake Week 1 of administration: Compared with the vehicle control group, the food intake of female mice in the high-dose group was significantly reduced (P<0.01).

[0079] Second week of administration: compared with the vehicle control group, the levels of female mice in the medium-dose group (P<0.05) and high-dose group (P<0.01) were significantly reduced, which was statistically significant.

[0080] At the third week of administration: compared with the vehicle control group, the levels of the medium and high dose groups in female rats were extremely significantly reduced (P<0.01), which was statistically significant; the high dose group in male rats was significantly reduced (P<0.05), which was statistically significant.

[0081] At the 4th week of administration: compared with the vehicle control group, the levels of leukemia in female rats in the medium (P<0.05) and high-dose groups (P<0.01) were significantly lower, which was statistically significant; the high-dose group in male rats was extremely significantly lower (P<0.01), which was statistically significant.

[0082] 2.3.2.4 Hematological tests 2.3.2.4.1 Routine blood test and coagulation test At the end of the dosing period: compared with the vehicle control group, there was no statistically significant difference in blood routine, blood coagulation and other indicators in the low, medium and high dose groups of the test article (P>0.05).

[0083] At the end of the recovery period: compared with the vehicle control group, the MCHC of male rats in the high-dose group was significantly reduced (P<0.01), which was statistically significant.

[0084] 2.3.2.4.2 Blood biochemistry At the end of the dosing period: compared with the vehicle control group, there was no statistically significant difference in the low, medium and high dose groups of the test article (P>0.05).

[0085] At the end of the recovery period: compared with the vehicle control group, the ALT level in the female rats in the medium-dose group was significantly reduced (P<0.05), which was statistically significant.

[0086] 2.3.2.4.3 Urine testing Macroscopic observation: The urine collected at the end of the medication period and the recovery period was light yellow and clear, with no pus or hematuria.

[0087] Statistical analysis: At the end of the administration period: there was no statistical significance between each dose group and the vehicle control group (P>0.05). At the end of the recovery period: there was no statistical significance between each dose group and the vehicle control group (P>0.05).

[0088] 2.3.2.5 Pathological examination 2.3.2.5.1 Visual observation At the end of the recovery period, the volume of bilateral testicles and epididymis of the animal in the vehicle control group (animal number 1113) was smaller, and no other obvious abnormalities were found. This lesion is related to spontaneous lesions.

[0089] 2.3.2.5.2 Organ weight and organ coefficient At the end of the administration period, there was no statistically significant difference in organ weight and organ coefficient between each dose group and the vehicle control group (P>0.05). At the end of the recovery period: the thymus weight and thymus coefficient of the female rats in the low-dose group (P<0.01) and high-dose group (P<0.05) were significantly reduced; the kidney weight of the female rats in the high-dose group was significantly reduced (P<0.05), which was statistically significant.

[0090] 2.3.2.5.3 Histopathological examination At the end of the administration period, a small number of scattered leukocyte foci and a small number of scattered inflammatory necrosis foci were found in the liver. The incidence rate in the vehicle control group was 2 / 20, and that in the high-dose group was 3 / 20. There was no significant difference between the high-dose group and the vehicle control group (P>0.05).

[0091] At the end of the recovery period, the seminiferous tubules of both testes of the animal in the vehicle control group (animal number 1113) were diffusely atrophied, with no germ cells, only residual supporting cells and proliferation of interstitial cells. This is considered to be an accidental lesion of the animal itself. A small number of scattered leukocyte foci were found in the liver. The incidence rate in the vehicle control group was 1 / 10, and that in the high-dose group was 0 / 10.

[0092] 2.3.2.6 Conclusion Under the conditions of this experiment, SD rats were given Dayuanyin (extract) by gavage for 28 days and recovered for 28 days. The results showed that:

[0093] 2.4.1 Changes in food intake During the administration period, the food intake of the animals in the medium and high dose groups of female mice and the high dose group of male mice decreased, indicating that the test product had a certain effect on the food intake of the animals. However, no obvious effect was observed during the recovery period, indicating that the change in food intake was reversible.

[0094] 2.4.2 Changes in general physical signs Animals in the high-dose group (64.50 g crude drug / kg) showed decreased autonomic activity after administration, which returned to normal 48 hours after drug withdrawal, indicating that the physical changes were reversible.

[0095] After administration, the animals in the medium-dose group and the high-dose group showed a significant decrease in food intake, and the animals in the high-dose group showed a decrease in activity, while the animals in the low-dose group showed no obvious abnormalities after administration. Therefore, the NOAEL for rats is ≤6.45 g crude drug / kg, and the toxic dose is ≥19.35 g crude drug / kg.

[0096] In summary, under the experimental conditions, the NOAEL of the Dayuanyin Chinese medicine for oral administration to SD rats is ≤6.45 g crude drug / kg, which is 3.1 times the equivalent dose of rats and 18.4 times the clinical dose. The toxic dose is ≥19.35 g crude drug / kg, which is equivalent to 9.2 times the equivalent dose of rats and 55.3 times the clinical dose. DETAILED DESCRIPTION

[0097] The present invention will be further explained and illustrated below in conjunction with specific embodiments: Example 1: A Chinese medicine for antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin. The raw materials for making its effective ingredients are, in parts by weight: 60 parts of betel nut, 30 parts of magnolia bark, 15 parts of tsaoko, 30 parts of anemarrhena, 30 parts of white peony root, 30 parts of astragalus, 15 parts of liquorice, 20 parts of radish seed, 20 parts of trichosanthes seed, 15 parts of raw aurantium, 20 parts of bupleurum, 10 parts of mulberry leaf, 10 parts of forsythia, 10 parts of artemisia annua, 5 parts of northern bean root, 10 parts of isatis indigotica, 10 parts of stir-fried coix seed, 20 parts of tangerine peel, 10 parts of purslane, 15 parts of rhubarb, and 15 parts of jujube.

[0098] The Dayuanyin Chinese medicine is an oral liquid.

[0099] The preparation method of the antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin Chinese medicine oral liquid comprises the following specific steps: ① Weigh the above raw materials according to the ratio, mix well, add 5 times the amount of drinking water, soak for 60 minutes, heat and boil for 90 minutes, filter while hot to obtain residue A and decoction A; ② Add 3 times the amount of drinking water as the raw material to the residue A, boil for 45 minutes, filter while hot, and obtain the residue B and decoction B; ③ Add 2 times the amount of drinking water as the raw material to the residue B, boil for 30 minutes, filter while hot, and obtain the residue C and decoction C; ④ Combine decoction A, decoction B and decoction C, let stand for 8 hours, pass the supernatant through a 200-mesh sieve, and obtain filtrate A for standby use; ⑤ The filtrate A is concentrated by heating in a negative pressure evaporator until the ratio of the mass of the medicinal material to the volume of the decoction liquid is 1:1.25; ⑥ After concentration, add clarifier, stir for 30 minutes, let stand for 3 hours, filter, and obtain filtrate B for standby use; ⑦ Add an appropriate amount of flavoring agent to filtrate B, stir for 30 minutes, let stand for 2 hours, filter, and pass the supernatant through a 200-mesh sieve to obtain filtrate C for standby use; ⑧ Boil an appropriate amount of drinking water, cool it to room temperature, add it to the filtrate C to make the total amount of liquid medicine, and adjust the Ph to 6.0-6.5; ⑨ After stirring, the mixture was allowed to stand for 1.5 hours. After passing the inspection, the mixture was centrifuged at high speed, sealed and sterilized to obtain the prepared antipyretic, analgesic, anti-inflammatory and antiviral oral liquid.

[0100] In step ⑥, the clarifier is chitosan flocculation clarifier, and the added amount is 1.5% of the volume of the drug solution.

[0101] In step ⑦, the flavoring agent is mogroside sweetener, and the added amount is 1.8% of the mass of filtrate B.

[0102] Example 2: A Chinese medicine for antipyretic, analgesic, anti-inflammatory and antiviral effects of Dayuanyin. The raw materials used to make its effective ingredients are, in parts by weight: 50 parts of betel nut, 20 parts of magnolia bark, 15 parts of tsaoko, 25 parts of anemarrhena, 25 parts of white peony root, 20 parts of astragalus, 15 parts of licorice, 20 parts of radish seeds, 20 parts of trichosanthes seeds, 15 parts of raw aurantium, 20 parts of bupleurum, 8 parts of mulberry leaves, 10 parts of forsythia, 8 parts of artemisia annua, 5 parts of northern bean root, 10 parts of isatis indigotica, 8 parts of stir-fried coix seeds, 20 parts of tangerine peel, 10 parts of purslane, 10 parts of rhubarb, and 10 parts of jujube.

[0103] The Dayuanyin Chinese medicine is an oral liquid.

[0104] The preparation method of the antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin Chinese medicine oral liquid comprises the following specific steps: ① Weigh the above raw materials according to the ratio, mix well, add 4 times the amount of drinking water, soak for 60 minutes, heat and boil for 75 minutes, filter while hot to obtain residue A and decoction A; ② Add 3 times the amount of drinking water as the raw material to the residue A, boil for 45 minutes, filter while hot, and obtain the residue B and decoction B; ③ Add 2 times the amount of drinking water as the raw material to the residue B, boil for 30 minutes, filter while hot, and obtain the residue C and decoction C; ④ Combine decoction A, decoction B and decoction C, let stand for 6 hours, pass the supernatant through a 200-mesh sieve, and obtain filtrate A for standby use; ⑤ The filtrate A is concentrated by heating in a negative pressure evaporator until the ratio of the mass of the medicinal material to the volume of the decoction liquid is 1:1.2; ⑥ After concentration, add clarifier, stir for 30 minutes, let stand for 4 hours, filter, and obtain filtrate B for standby use; ⑦ Add an appropriate amount of flavoring agent to filtrate B, stir for 30 minutes, let stand for 2 hours, filter, and pass the supernatant through a 200-mesh sieve to obtain filtrate C for standby use; ⑧ Boil an appropriate amount of drinking water, cool it to room temperature, add it to the filtrate C to make the total amount of liquid medicine, and adjust the Ph to 6.0-6.5; ⑨ After stirring, the mixture was allowed to stand for 1 hour. After passing the inspection, the mixture was centrifuged at high speed, sealed and sterilized to obtain the prepared antipyretic, analgesic, anti-inflammatory and antiviral oral liquid.

[0105] In step ⑥, the clarifier is chitosan flocculation clarifier, and the added amount is 1.3% of the volume of the drug solution.

[0106] In step ⑦, the flavoring agent is mogroside sweetener, and the added amount is 1.8% of the mass of filtrate B.

[0107] Example 3: A Chinese medicine for antipyretic, analgesic, anti-inflammatory and antiviral effects of Dayuanyin. The raw materials used to make its effective ingredients are, in parts by weight: 60 parts of betel nut, 30 parts of magnolia bark, 20 parts of tsaoko, 30 parts of rhubarb, 30 parts of white peony root, 30 parts of astragalus, 20 parts of licorice, 25 parts of radish seeds, 25 parts of trichosanthes seeds, 20 parts of raw aurantium, 25 parts of bupleurum, 10 parts of mulberry leaves, 20 parts of forsythia, 10 parts of artemisia annua, 10 parts of northern bean root, 15 parts of isatis indigotica, 10 parts of stir-fried coix seeds, 22 parts of tangerine peel, 15 parts of purslane, 20 parts of rhubarb, and 15 parts of jujube.

[0108] The Dayuanyin Chinese medicine is a powder.

[0109] Example 4: A Chinese medicine for antipyretic, analgesic, anti-inflammatory and antiviral effects of Dayuanyin. The raw materials used to make its effective ingredients are, in parts by weight: 55 parts of betel nut, 25 parts of magnolia bark, 18 parts of tsaoko, 25-30 parts of anemarrhena, 25 parts of white peony root, 25 parts of astragalus, 15 parts of liquorice, 25 parts of radish seeds, 20 parts of trichosanthes seeds, 20 parts of raw aurantium, 20 parts of bupleurum, 10 parts of mulberry leaves, 20 parts of forsythia, 10 parts of artemisia annua, 10 parts of northern bean root, 15 parts of isatis indigotica, 10 parts of stir-fried coix seeds, 20 parts of tangerine peel, 10 parts of purslane, 20 parts of rhubarb, and 15 parts of jujube.

[0110] The Dayuanyin Chinese medicine for relieving fever, relieving pain, reducing inflammation and resisting virus is in the form of powder.

[0111] Example 5: A Chinese medicine for antipyretic, analgesic, anti-inflammatory and antiviral effects of Dayuanyin. The raw materials used to make its effective ingredients are, in parts by weight: 52 parts of betel nut, 28 parts of magnolia bark, 16 parts of tsaoko, 28 parts of rhubarb, 26 parts of white peony root, 22 parts of astragalus, 17 parts of liquorice, 23 parts of radish seed, 22 parts of trichosanthes seed, 19 parts of raw aurantium, 24 parts of bupleurum, 9 parts of mulberry leaf, 16 parts of forsythia, 9 parts of artemisia annua, 7 parts of northern bean root, 11 parts of isatis indigotica, 9 parts of stir-fried coix seed, 21 parts of tangerine peel, 13 parts of purslane, 14 parts of rhubarb, and 15 parts of jujube.

[0112] The Dayuanyin Chinese medicine is a Dayuanyin extract.

[0113] Example 6: A Chinese medicine Dayuanyin for antipyretic, analgesic, anti-inflammatory and antiviral effects. The raw materials used to make its effective ingredients are, in parts by weight: 52 parts of betel nut, 23 parts of magnolia bark, 17 parts of tsaoko, 29 parts of rhubarb, 26 parts of white peony root, 27 parts of astragalus, 16 parts of liquorice, 21 parts of radish seed, 22 parts of trichosanthes seed, 18 parts of raw aurantium, 23 parts of bupleurum, 9 parts of mulberry leaf, 18 parts of forsythia, 8 parts of artemisia annua, 10 parts of northern bean root, 13 parts of isatis indigotica, 10 parts of stir-fried coix seed, 24 parts of tangerine peel, 14 parts of purslane, 16 parts of rhubarb, and 15 parts of jujube.

[0114] The Dayuanyin Chinese medicine is a Dayuanyin extract.

[0115] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Multiple embodiments can be formed by changing the content of each component. For ordinary technicians in this field, any modifications, equivalent substitutions, improvements, etc. made without departing from the principles and spirit of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Dayuanyin Chinese medicine for relieving fever, relieving pain, reducing inflammation and resisting virus, characterized in that: The raw materials for making the effective ingredients are as follows: 50-60 parts of betel nut, 20-30 parts of magnolia bark, 15-20 parts of tsaoko, 25-30 parts of rhizoma anemarrhenae, 25-30 parts of white peony root, 20-30 parts of astragalus, 15-20 parts of liquorice, 20-25 parts of radish seeds, 20-25 parts of trichosanthes seeds, 15-20 parts of raw aurantium, 20-25 parts of bupleurum, 8-10 parts of mulberry leaves, 10-20 parts of forsythia, 8-10 parts of artemisia annua, 5-10 parts of northern bean root, 10-15 parts of isatis indigotica, 8-10 parts of stir-fried coix seeds, 20-22 parts of tangerine peel, 10-15 parts of purslane, 10-20 parts of rhubarb and 10-15 parts of jujube.

2. The antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin Chinese medicine according to claim 1, characterized in that: The raw materials for making its effective ingredients are as follows: 60 parts by weight, 30 parts by magnolia bark, 15 parts by tsaoko, 30 parts by rhizoma anemarrhenae, 30 parts by white peony root, 30 parts by astragalus, 15 parts by liquorice, 20 parts by radish seed, 20 parts by trichosanthes seed, 15 parts by raw aurantium, 20 parts by bupleurum, 10 parts by mulberry leaf, 10 parts by forsythia, 10 parts by artemisia annua, 5 parts by northern bean root, 10 parts by isatis indigotica, 10 parts by stir-fried coix seed, 20 parts by dried tangerine peel, 10 parts by purslane, 15 parts by rhubarb, and 15 parts by jujube.

3. The antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin Chinese medicine according to claims 1 to 2, characterized in that: The traditional Chinese medicine is in the form of powder, extract or oral liquid.

4. The preparation method of the oral liquid of the antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin Chinese medicine according to claim 3, wherein the specific steps are as follows: ① Weigh the above raw materials according to the ratio, mix well, add 4 to 5 times the amount of drinking water, soak for 45 to 60 minutes, heat and boil for 75 to 90 minutes, filter while hot to obtain residue A and decoction A; ② Add 3 to 4 times the amount of drinking water as the raw material to the residue A, boil for 45 to 60 minutes, filter while hot, and obtain the residue B and decoction B; ③ Add 1 to 2 times the amount of drinking water as the raw material to the residue B, boil for 30 to 45 minutes, filter while hot, and obtain residue C and decoction C; ④ Combine decoction A, decoction B and decoction C, let stand for 6 to 10 hours, pass the supernatant through a 200-mesh sieve, and obtain filtrate A for later use; ⑤ The filtrate A is concentrated by heating in a negative pressure evaporator until the ratio of the mass of the medicinal material to the volume of the decoction is 1: (1.2-1.5); ⑥ After concentration, add an appropriate amount of clarifier, stir for 25 to 40 minutes, let stand for 2 to 5 hours, filter, and obtain filtrate B for standby use; ⑦ Add an appropriate amount of flavoring agent to filtrate B, stir for 25 to 40 minutes, let stand for 2 to 3 hours, filter, and pass the supernatant through a 200-mesh sieve to obtain filtrate C for standby use; ⑧ Boil an appropriate amount of drinking water, cool it to room temperature, add it to the filtrate C to make the total amount of liquid medicine, and adjust the Ph to 6.0-6.5; ⑨ After stirring, the mixture is allowed to stand for 1 to 2 hours. After passing the inspection, the mixture is centrifuged at high speed, sealed, and sterilized to obtain the prepared antipyretic, analgesic, anti-inflammatory, and antiviral oral liquid.

5. The method for preparing the antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin oral liquid according to claim 4, characterized in that: In step ⑥, the clarifier is a chitosan flocculation clarifier, and the amount of the clarifier added is 1% to 2% of the volume of the drug solution.

6. The method for preparing the antipyretic, analgesic, anti-inflammatory and antiviral Dayuanyin oral liquid according to claim 4, characterized in that: In step ⑦, the flavoring agent is mogroside sweetener, and the added amount is 1.5% to 2% of the mass of filtrate B.

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