Tightening thixotropic gel and preparation method thereof

Abstract

The invention aims to provide tightening thixotropic gel and a preparation method thereof, and belongs to the technical field of gel. According to the tightening thixotropic gel disclosed by the invention, a thickening agent component of a basic component of the tightening thixotropic gel is optimized, and L Cosmetax HealJell-Advance is cooperated with sodium hyaluronate, hydrolyzed collagen, bio-saccharide gum-1, ascorbic acid (vitamin C) and a centella asiatica extract to increase the private tightening degree; unstable melaleuca alternifolia leaf oil, ascorbic acid (vitamin C) and glycyrrhizic acid are prepared into nano-particles, so that the stability of the gel is improved, functional components are slowly released through the nano-particles, and the tightening effect of the gel lasts for a longer time; the melaleuca alternifolia leaf oil, chitosan, glycyrrhizic acid and centella asiatica extract are used as an antibacterial system to replace traditional antibiotics or silver ions, and growth and reproduction of harmful bacteria are inhibited on the basis that beneficial bacteria are not damaged.

Description

Technical Field

[0001] The invention belongs to the technical field of gel and relates to a compact thixotropic gel and a preparation method thereof. Background Art

[0002] In recent years, the female intimate care product market has developed rapidly, especially the demand for tightening products for vaginal relaxation has increased. Vaginal relaxation is mainly caused by factors such as childbirth and aging, which affects women's quality of life and self-confidence. Traditional tightening methods include surgery and laser treatment. Although they are effective, they have high risks, high costs and long recovery periods. Therefore, non-invasive, effective and easy-to-use external tightening thixotropic gels have gradually attracted attention.

[0003] There are two main categories of tightening thixotropic gels: the first category is plant extract gels, which mainly use plant extracts, such as witch hazel and aloe vera, to achieve tightening effects through their astringent effects. Although these products are more natural, their tightening effects usually last for a short time and require frequent use. The second category is synthetic polymer gels, which use synthetic polymer materials to temporarily tighten the vaginal wall by forming a physical barrier. Although the product effect is better, the safety and biocompatibility of the ingredients are often questioned, which may cause discomfort or allergic reactions.

[0004] Although the existing tightening thixotropic gel can improve the problem of vaginal relaxation to a certain extent, it still has technical defects such as short duration of effect and ingredient safety issues. The purpose of the present invention is to provide an innovative tightening thixotropic gel, aiming to provide an efficient and safe tightening thixotropic gel by improving the formula and preparation process, including: optimizing the ingredients and innovating the process to make the tightening effect of the gel last longer; selecting natural ingredients with good biocompatibility and no irritation to reduce the risk of allergies and discomfort. Summary of the invention

[0005] The purpose of the present invention is to provide a tightening thixotropic gel and a preparation method thereof, which belongs to the technical field of gel. The present invention optimizes the thickener component of the tightening thixotropic gel base component, uses LCosmetix HealJelly-Advance, and cooperates with sodium hyaluronate, hydrolyzed collagen, biosaccharide gum-1, ascorbic acid (vitamin C) and Centella asiatica extract to increase the private firmness; prepares unstable Melaleuca alternifolia leaf oil, ascorbic acid (vitamin C) and glycyrrhizic acid into nanoparticles to improve its stability and the nanoparticles enable the functional components to be slowly released, so that the tightening effect of the gel lasts longer; uses Melaleuca alternifolia leaf oil, deacetylated chitosan, glycyrrhizic acid and Centella asiatica extract as an antibacterial system to replace traditional antibiotics or silver ions, so as to inhibit the growth and reproduction of harmful bacteria without destroying beneficial bacteria.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] A compact thixotropic gel, comprising the following raw materials in parts by weight:

[0008]

[0009] As a preferred technical solution of the present invention, the L Cosmetix HealJelly-Advance comprises: aloe vera leaf juice, sodium alginate, mushroom extract, red sesame extract, shiitake mushroom extract, and inonotus obliquus extract, and the preparation method is: 1-3 parts by weight of sodium alginate is stirred and dissolved in 20-60 parts by weight of deionized water, 5-15 parts by weight of aloe vera leaf juice, 0.5-2 parts by weight of mushroom extract, 0.5-2 parts by weight of red sesame extract, 0.5-2 parts by weight of shiitake mushroom extract and 0.5-2 parts by weight of inonotus obliquus extract are added, stirred evenly, and then fully mixed with a homogenizer. .

[0010] As a preferred technical solution of the present invention, the preparation method of the nanoemulsion is: 0.5-5 weight parts of hydrogenated lecithin are dissolved in 1-5 weight parts of anhydrous ethanol, and then 0.1-5 weight parts of Melaleuca alternifolia leaf oil are added and stirred evenly to obtain an oil phase; 0.1-1 weight parts of ascorbic acid (vitamin C) and 0.1-1 weight parts of glycyrrhizic acid are stirred and completely dissolved in 4-12 weight parts of PBS buffer to obtain an aqueous phase; the oil phase is slowly added dropwise to the aqueous phase, and an ultrasonic emulsifier is used to emulsify for 10-50 minutes, and then a stabilization treatment is performed to form a uniform nanoemulsion.

[0011] As a preferred technical solution of the present invention, the PBS buffer concentration is 20 mM and the pH is 5.5-7.0.

[0012] As a preferred technical solution of the present invention, the stabilization treatment is to continue stirring at 0-10°C for 30-90 minutes.

[0013] As a preferred technical solution of the present invention, the preservative is PCO.

[0014] Furthermore, a method for preparing a compact thixotropic gel is characterized by comprising the following steps:

[0015] (1) Add L Cosmetix HealJelly-Advance, sodium hyaluronate, chitosan, biosaccharide gum-1, Centella asiatica extract, and hydrolyzed collagen to deionized water and stir until completely dissolved to prepare solution A;

[0016] (1) adding the nanoemulsion dropwise into solution A and stirring to form a uniform emulsion;

[0017] (3) adjusting the pH of the emulsion to 3.8-5.8 using lactic acid, and treating with an ultrasonic emulsifier for 15-20 minutes to form a gel;

[0018] (4) First, the gel is transferred to a magnetic stirrer and stirred continuously for 30-90 minutes; after the stirring is completed, the incompletely emulsified part is removed by centrifugation at 8000-12000 rpm for 10-20 minutes; the prepared gel is allowed to stand for more than 8 hours to obtain a compact thixotropic gel.

[0019] As a preferred technical solution of the present invention, the emulsion stirring process in step (4) is carried out in an ice water bath, and the stirring time is 20-30 minutes.

[0020] Beneficial effects of the present invention:

[0021] (1) The present invention optimizes the thickener component, uses L Cosmetix HealJelly-Advance A as a film-forming agent and L Cosmetix HealJelly-Advance as a base component, replacing the carbomer system with a high initial viscosity, low fluidity, and inability to completely cover the vaginal wall during administration. The system is not only easy to apply, but also can evenly cover the skin surface and provide a sustained firming effect. The natural polysaccharide biosaccharide gum-1 with good elasticity and touch is added to enhance the softness and comfort of the gel and improve the user experience. The synergistic effect of sodium hyaluronate, hydrolyzed collagen and Centella asiatica extract provides a strong moisturizing, repairing and firming effect, improves skin texture and elasticity, and the antioxidant effect of ascorbic acid (vitamin C) can protect the skin from oxidative damage and improve the health and firmness of the skin.

[0022] (2) Volatile Melaleuca alternifolia leaf oil, highly oxidizable ascorbic acid (vitamin C), and easily hydrolyzed glycyrrhizic acid are prepared into nanoparticles. The stability and bioavailability of the nanoparticles are significantly improved by using hydrogenated lecithin, ethanol, and PBS buffer. The liposome structure formed by hydrogenated lecithin can encapsulate unstable active ingredients to form liposomes, which protect them inside the hydrophobic core from oxygen, light, and moisture, thereby reducing the risk of degradation. The small size of the nanoparticles enhances the skin penetration of the ingredients, prolongs the duration of action through a sustained-release mechanism, reduces the irritation of the active ingredients, and improves efficacy and safety.

[0023] (3) The combination of Melaleuca alternifolia leaf oil, chitosan, glycyrrhizic acid, Centella asiatica extract and lactic acid can selectively inhibit harmful bacteria without destroying beneficial bacteria. Melaleuca alternifolia leaf oil selectively destroys bacterial cell membranes, chitosan destroys pathogens by interacting with cell walls, glycyrrhizic acid interferes with bacterial metabolism, and Centella asiatica extract inhibits pathogens and promotes healing; lactic acid lowers the pH value and inhibits the growth of pathogens, while beneficial vaginal bacteria are more adaptable to acidic environments; this synergistic effect and targeted action enable the combination to effectively inhibit harmful bacteria while protecting the ecological balance of beneficial bacteria. DETAILED DESCRIPTION

[0024] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0025] In the following examples and comparative examples, the L Cosmetix HealJelly-Advance (aloe vera leaf juice, sodium alginate, Agaricus oleraceus extract, Ganoderma lucidum extract, Lentinus edodes extract, Inonotus birch extract) was purchased from LCOSMETIXLIMITED Laidu Beauty Technology Co., Ltd.; chitosan was purchased from Nanjing Gutian Chemical Co., Ltd.; Melaleuca alternifolia leaf oil was purchased from Guangzhou Yueze Chemical Co., Ltd.; Centella asiatica extract was purchased from Guangxi Changzhou Natural Pharmaceutical Co., Ltd.; hydrolyzed collagen was purchased from Guangzhou Youran Biotechnology Co., Ltd., and the PCO was purchased from PCI INNOVATIVECHEMICALS SDN.BHD.

[0026] Example 1

[0027] A compact thixotropic gel, comprising the following raw materials in parts by weight:

[0028]

[0029] The L Cosmetix HealJelly-Advance comprises: aloe vera leaf juice, sodium alginate, mushroom extract, red radish extract, shiitake mushroom extract, and inonotus obliquus extract. The preparation method is: 2 parts by weight of sodium alginate is stirred and dissolved in 40 parts by weight of deionized water, 10 parts by weight of aloe vera leaf juice, 1 part by weight of mushroom extract, 1 part by weight of red radish extract, 1 part by weight of shiitake mushroom extract and 1 part by weight of inonotus obliquus extract are added, stirred evenly, and then fully mixed with a homogenizer.

[0030] The preparation method of the nanoemulsion comprises the following steps: dissolving 1 part by weight of hydrogenated lecithin in 3 parts by weight of anhydrous ethanol, adding 1 part by weight of Melaleuca alternifolia leaf oil and stirring evenly to obtain an oil phase; stirring and completely dissolving 0.5 parts by weight of ascorbic acid (vitamin C) and 0.2 parts by weight of glycyrrhizic acid in 8 parts by weight of PBS buffer to obtain an aqueous phase; slowly dropping the oil phase into the aqueous phase, and simultaneously performing emulsification for 30 minutes using an ultrasonic emulsifier, and then performing stabilization treatment to form a uniform nanoemulsion.

[0031] The PBS buffer has a concentration of 20 mM and a pH of 6.0.

[0032] The stabilization treatment is to continue stirring at 4° C. for 60 minutes to ensure the stability of the system.

[0033] The preservative is PCO.

[0034] The method for preparing a compact thixotropic gel comprises the following steps:

[0035] (1) Add L Cosmetix HealJelly-Advance, sodium hyaluronate, chitosan, biosaccharide gum-1, Centella asiatica extract, and hydrolyzed collagen to deionized water and stir until completely dissolved to prepare solution A;

[0036] (2) adding the nanoemulsion dropwise into solution A and stirring to form a uniform emulsion;

[0037] (3) adjusting the pH of the emulsion to 4.2 using lactic acid, and treating with an ultrasonic emulsifier for 20 minutes to form a gel;

[0038] (4) The gel was first transferred to a magnetic stirrer and stirred continuously for 60 minutes. After the stirring was completed, the incompletely emulsified part was removed by centrifugation at 10,000 rpm for 15 minutes. The prepared gel was allowed to stand for 12 hours to obtain a compact thixotropic gel.

[0039] As a preferred technical solution of the present invention, the emulsion stirring process in step (4) is carried out in an ice water bath, and the stirring time is 25 minutes.

[0040] Example 2

[0041] A compact thixotropic gel, comprising the following raw materials in parts by weight:

[0042]

[0043]

[0044] The L Cosmetix HealJelly-Advance comprises: aloe vera leaf juice, sodium alginate, mushroom extract, red radish extract, shiitake mushroom extract, and inonotus obliquus extract. The preparation method is: 2 parts by weight of sodium alginate is stirred and dissolved in 40 parts by weight of deionized water, 10 parts by weight of aloe vera leaf juice, 1 part by weight of mushroom extract, 1 part by weight of red radish extract, 1 part by weight of shiitake mushroom extract and 1 part by weight of inonotus obliquus extract are added, stirred evenly, and then fully mixed with a homogenizer.

[0045] The preparation method of the nanoemulsion comprises the following steps: dissolving 0.8 weight parts of hydrogenated lecithin in 2 weight parts of anhydrous ethanol, adding 0.5 weight parts of Melaleuca alternifolia leaf oil and stirring evenly to obtain an oil phase; stirring and completely dissolving 0.2 weight parts of ascorbic acid (vitamin C) and 0.2 weight parts of glycyrrhizic acid in 6.1 weight parts of PBS buffer to obtain an aqueous phase; slowly dropping the oil phase into the aqueous phase, and simultaneously performing emulsification for 30 minutes using an ultrasonic emulsifier, and then performing stabilization treatment to form a uniform nanoemulsion.

[0046] The PBS buffer has a concentration of 20 mM and a pH of 6.0.

[0047] The stabilization treatment is to continue stirring at 4° C. for 60 minutes to ensure the stability of the system.

[0048] The preservative is PCO.

[0049] The method for preparing a compact thixotropic gel comprises the following steps:

[0050] (1) Add L Cosmetix HealJelly-Advance, sodium hyaluronate, chitosan, biosaccharide gum-1, Centella asiatica extract, and hydrolyzed collagen to deionized water and stir until completely dissolved to prepare solution A;

[0051] (2) adding the nanoemulsion dropwise into solution A and stirring to form a uniform emulsion;

[0052] (3) adjusting the pH of the emulsion to 4.2 using lactic acid, and treating with an ultrasonic emulsifier for 20 minutes to form a gel;

[0053] (4) The gel was first transferred to a magnetic stirrer and stirred continuously for 60 minutes. After the stirring was completed, the incompletely emulsified part was removed by centrifugation at 10,000 rpm for 15 minutes. The prepared gel was allowed to stand for 12 hours to obtain a compact thixotropic gel.

[0054] As a preferred technical solution of the present invention, the emulsion stirring process in step (4) is carried out in an ice water bath, and the stirring time is 25 minutes.

[0055] Comparative Example 1

[0056] Based on Example 2, sodium alginate was not added, the amount of aloe vera leaf juice added was 12 parts by weight, and the rest was consistent with Example 2.

[0057] Comparative Example 2

[0058] Based on Example 2, no aloe vera leaf juice was added, the amount of sodium alginate added was 12 parts by weight, and the rest was consistent with Example 2.

[0059] Comparative Example 3

[0060] On the basis of Example 2, no Agaricus oleifera extract was added, and the amount of Ganoderma lucidum extract added was 2 parts by weight. The rest was consistent with Example 2.

[0061] Comparative Example 4

[0062] On the basis of Example 2, no red ganoderma extract was added, and the amount of shiitake mushroom extract added was 2 parts by weight, and the rest was consistent with Example 2.

[0063] Comparative Example 5

[0064] On the basis of Example 2, no Lentinus edodes extract was added, and the added amount of Inonotus obliquus extract was 2 parts by weight, and the rest was consistent with Example 2.

[0065] Comparative Example 6

[0066] On the basis of Example 2, no Inonotus obliquus extract was added, and the amount of Agaricus oleraceus extract added was 2 parts by weight, and the rest was consistent with Example 2.

[0067] Comparative Example 7

[0068] Based on Example 2, no biosaccharide gum-1 was added, the amount of sodium hyaluronate added was 2.5 parts by weight, and the rest was consistent with Example 2.

[0069] Comparative Example 8

[0070] Based on Example 2, sodium hyaluronate was not added, the amount of hydrolyzed collagen added was 1.5 parts by weight, and the rest was consistent with Example 2.

[0071] Comparative Example 9

[0072] Based on Example 2, no hydrolyzed collagen was added, the amount of Centella asiatica extract added was 2 parts by weight, and the rest was consistent with Example 2.

[0073] Comparative Example 10

[0074] Based on Example 2, no Centella asiatica extract was added, the amount of ascorbic acid (vitamin C) added was 1.2 parts by weight, and the rest was consistent with Example 2.

[0075] Comparative Example 11

[0076] Based on Example 2, ascorbic acid (vitamin C) was not added, the amount of biosaccharide gum-1 added was 2.2 parts by weight, and the rest was consistent with Example 2.

[0077] Comparative Example 12

[0078] On the basis of Example 2, Melaleuca alternifolia leaf oil, ascorbic acid (vitamin C) and glycyrrhizic acid are not prepared into a nanoemulsion, specifically comprising:

[0079] A compact thixotropic gel, comprising the following raw materials in parts by weight:

[0080]

[0081]

[0082] The L Cosmetix HealJelly-Advance comprises: aloe vera leaf juice, sodium alginate, mushroom extract, red ginseng extract, shiitake mushroom extract, and inonotus obliquus extract. The preparation method is: 2 parts by weight of sodium alginate is stirred and dissolved in 40 parts by weight of deionized water, 10 parts by weight of aloe vera leaf juice, 1 part by weight of mushroom extract, 1 part by weight of red ginseng extract, 1 part by weight of shiitake mushroom extract and 1 part by weight of inonotus obliquus extract are added, stirred evenly, and then fully mixed with a homogenizer.

[0083] The preservative is PCO.

[0084] The method for preparing a compact thixotropic gel comprises the following steps:

[0085] (1) Add L Cosmetix HealJelly-Advance, sodium hyaluronate, chitosan, Melaleuca alternifolia leaf oil, biosaccharide gum-1, Centella asiatica extract, glycyrrhizic acid, hydrolyzed collagen and ascorbic acid (vitamin C) into deionized water according to the formula, and stir until completely dissolved to prepare solution A;

[0086] (2) using lactic acid to slowly adjust the pH of solution A to 4.2, gradually adding solution A to solution A, and treating with an ultrasonic emulsifier for 20 min to ensure uniform dispersion and gel formation;

[0087] (3) The gel was first transferred to a magnetic stirrer and stirred continuously for 60 minutes. After stirring, the gel was centrifuged at 10,000 rpm for 15 minutes to remove the incompletely emulsified portion. The prepared gel was allowed to stand for 12 hours to obtain a compact thixotropic gel.

[0088] Comparative Example 13

[0089] On the basis of Example 2, lactic acid was not used to adjust the pH, and the pH of the phosphate buffer solution PBS was adjusted to 4.2. The rest was consistent with Example 2.

[0090] Comparative Example 14

[0091] On the basis of Example 2, no Melaleuca alternifolia leaf oil was added, the amount of chitosan added was 0.7 parts by weight, and the rest was consistent with Example 2.

[0092] Comparative Example 15

[0093] Based on Example 2, no chitosan was added, the amount of glycyrrhizic acid added was 0.4 parts by weight, and the rest was consistent with Example 2.

[0094] Comparative Example 16

[0095] Based on Example 2, no glycyrrhizic acid was added, the amount of Centella asiatica extract added was 1.2 parts by weight, and the rest was consistent with Example 2.

[0096] Comparative Example 17

[0097] On the basis of Example 2, no Centella asiatica extract was added, and the amount of Melaleuca alternifolia leaf oil added was 1.5 parts by weight, and the rest was consistent with Example 2.

[0098] Performance Testing

[0099] 1. Tightening vagina test:

[0100] 140 married women aged 25-50 with vaginal relaxation were randomly divided into 14 groups, with 10 people in each group. The gels of Examples 1-2 and Comparative Examples 1-12 were used on the patients in Groups 1-14, once every two days, one 15 mL gel each time, for 30, 60 and 90 days, and the symptoms and signs of the patients after using the products were recorded.

[0101] Effective judgment criteria: The effective criteria are that the transverse diameter and volume of vaginal relaxation have improved and the patients are satisfied; the ineffective criteria are that the transverse diameter and volume of vagina have not changed and the patients are dissatisfied. The results are shown in Table 1.

[0102] Table 1 Vaginal tightening effectiveness (%) of Examples 1-2 and Comparative Examples 1-14

[0103] Group 30 days effective 60 days effective 90 days effective Example 1 80 100 100 Example 2 80 100 100 Comparative Example 1 60 70 80 Comparative Example 2 70 70 80 Comparative Example 3 60 70 80 Comparative Example 4 60 70 70 Comparative Example 5 60 70 80 Comparative Example 6 70 70 80 Comparative Example 7 70 70 80 Comparative Example 8 60 70 80 Comparative Example 9 60 60 70 Comparative Example 10 70 70 80 Comparative Example 11 70 80 80 Comparative Example 12 60 70 70

[0104] 2. Safety test: According to GB15979-2002 standard test, the results are shown in Table 2.

[0105] Table 2 Safety test of Example 1-2

[0106] Group Skin irritation index Skin sensitization Example 1 0 0 Example 2 0 0

[0107] 3. Antibacterial test:

[0108] According to the method specified in Appendix C of GB15979-2002, the antibacterial rate test results of the gels prepared in Examples 1-2 and Comparative Examples 14-19 on Escherichia coli, Staphylococcus aureus, Candida albicans and Lactobacillus for 20 minutes are recorded as shown in Table 3 below.

[0109] Table 3 Inhibition rate of each bacteria in Examples 1-2 and Comparative Examples 12-17 (%)

[0110] Group Escherichia coli Staphylococcus aureus Candida albicans Example 1 97.4 97 98.5 Example 2 96.9 97.2 96.8 Comparative Example 12 96.8 94 82 Comparative Example 13 96.2 88.7 72.6 Comparative Example 14 95.8 89.5 78.2 Comparative Example 15 95.6 91.3 81.4 Comparative Example 16 94.2 89.1 80.5 Comparative Example 17 89.7 88.9 76.2

[0111] Test on the inhibition of beneficial bacteria lactobacillus: after activating lactobacillus and vaginal bifidobacterium, pick up a single colony and put it into 5 ml of the corresponding liquid culture medium, and culture it at 37°C for 12 hours; take 100 pL, dilute it 10 times, and then take 100 μL of the bacterial suspension and spread it evenly on the solid culture medium plate, apply the compact thixotropic gel in Example 1-2 to the surface of a sterile filter paper with a radius of 3 mm and a thickness of 10 μm, and stick the smeared surface on the bacteria-containing plate, and culture it at 37°C for 12 hours, and measure the antibacterial radius of the filter paper. The results are shown in Table 4.

[0112] Table 4 Example 1-2 Antibacterial zone radius of beneficial bacteria (mm)

[0113] Group Lactobacilli Bifidobacterium vaginalis Example 1 3.2 3.3 Example 2 3.2 3.2

[0114] From the test results in Table 1, it can be seen that compared with Comparative Examples 1-12, Examples 1-2 of the present invention use polyvinyl alcohol as a film-forming agent in combination with L Cosmetix HealJelly-Advance B, in synergy with sodium hyaluronate, Centella asiatica extract, hydrolyzed collagen, biosaccharide gum-1 and ascorbic acid (vitamin C), providing a significant firming effect and improving skin texture and elasticity.

[0115] From the test results in Table 2, it can be seen that Example 1-2 minimizes skin irritation and sensitization by optimizing the basic ingredients of the gel, adding natural soothing ingredients and nano-sustained release technology.

[0116] From the test results of Table 3 and Table 4, it can be seen that the combination of Melaleuca alternifolia leaf oil, chitosan, glycyrrhizic acid, Centella asiatica extract and lactic acid can selectively inhibit harmful bacteria without substantially destroying beneficial bacteria.

[0117] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. A compact thixotropic gel, characterized in that: The compact thixotropic gel comprises the following raw materials in parts by weight:

2. A compact thixotropic gel according to claim 1, characterized in that: The L Cosmetix HealJelly-Advance comprises: aloe vera leaf juice, sodium alginate, mushroom extract, red radish extract, shiitake mushroom extract, and inonotus obliquus extract. The preparation method of the L Cosmetix HealJelly-Advance is as follows: 1-3 parts by weight of sodium alginate is stirred and dissolved in 20-60 parts by weight of deionized water, 5-15 parts by weight of aloe vera leaf juice, 0.5-2 parts by weight of mushroom extract, 0.5-2 parts by weight of red radish extract, 0.5-2 parts by weight of shiitake mushroom extract, and 0.5-2 parts by weight of inonotus obliquus extract are added, stirred evenly, and then fully mixed with a homogenizer. .

3. A compact thixotropic gel according to claim 1, characterized in that: The preparation method of the nanoemulsion comprises the following steps: dissolving 0.5-5 parts by weight of hydrogenated lecithin in 1-5 parts by weight of anhydrous ethanol, adding 0.1-5 parts by weight of Melaleuca alternifolia leaf oil and stirring evenly to obtain an oil phase; stirring and completely dissolving 0.1-1 parts by weight of ascorbic acid (vitamin C) and 0.1-1 parts by weight of glycyrrhizic acid in 4-12 parts by weight of PBS buffer to obtain a water phase; slowly dropping the oil phase into the water phase, and simultaneously performing emulsification for 10-50 minutes using an ultrasonic emulsifier, and then performing stabilization treatment to form a uniform nanoemulsion.

4. A compact thixotropic gel according to claim 3, characterized in that: The PBS buffer has a concentration of 20 mM and a pH of 5.5-7.

0.

5. The compact thixotropic gel according to claim 3, characterized in that: The stabilization treatment is to continue stirring at 0-10° C. for 30-90 minutes.

6. The compact thixotropic gel according to claim 1, characterized in that: The preservative is PCO.

7. A method for preparing a compact thixotropic gel according to any one of claims 1 to 6, characterized in that: The following steps are involved: (1) Add L Cosmetix HealJelly-Advance, sodium hyaluronate, chitosan, biosaccharide gum-1, Centella asiatica extract, and hydrolyzed collagen to deionized water and stir until completely dissolved to prepare solution A; (2) adding the nanoemulsion dropwise into solution A and stirring to form a uniform emulsion; (3) adjusting the pH of the emulsion to 3.8-5.8 using lactic acid, and treating with an ultrasonic emulsifier for 15-20 minutes to form a gel; (4) First, the gel is transferred to a magnetic stirrer and stirred continuously for 30-90 minutes; after the stirring is completed, the incompletely emulsified part is removed by centrifugation at 8000-12000 rpm for 10-20 minutes; the prepared gel is allowed to stand for more than 8 hours to obtain a compact thixotropic gel.

8. The method for preparing a compact thixotropic gel according to claim 7, characterized in that: The emulsion stirring process in step (4) is carried out in an ice-water bath, and the stirring time is 20-30 minutes.

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