Topramezone phytotoxicity resistant herbicide composition for gramineous grains

Abstract

The invention provides a herbicide composition for resisting topramezone phytotoxicity. The herbicide composition comprises a p-hydroxyphenylpyruvate dioxygenase inhibitor and a herbicide safener containing a quinolin structure, according to the herbicide composition prepared by the invention, the phytotoxicity of the herbicide on gramineous crops such as wheat, rice and millet can be reduced under the condition that the efficacy of the herbicide is not influenced; aiming at three different gramineous crops including wheat, rice and millet, the composition disclosed by the invention is remarkably superior to the effect of relieving the phytotoxicity of the herbicide to the wheat in the aspect of relieving the phytotoxicity of the herbicide to the rice and the millet.

Description

Technical Field

[0001] The invention relates to the field of herbicide safeners, and in particular to a herbicide composition for resisting fenacet-butyl phytotoxicity to gramineous cereals. Background Art

[0002] Due to the irrational use of herbicides and the selectivity of weeds themselves, more and more weeds are showing high resistance to herbicides, making it very difficult to control them. One of the conventional solutions is to increase the dosage and mix multiple compounds, but this will lead to further increase in weed resistance and crop damage. The reasons for herbicide damage are particularly complex, mainly including inappropriate selection of herbicides, failure to apply herbicides according to the correct use method and dosage standards, unreasonable schedule of application, incorrect application method of herbicides, uneven spraying of herbicides, etc.

[0003] The emergence of herbicide safeners has solved the problem of herbicide damage very well. Herbicide safeners are also called antidotes or protectants. Simply put, they are compounds used to protect crops from herbicide damage, thereby increasing the safety of crops and improving the weed control effect. They protect crops by accelerating metabolism, increasing enzyme activity, and upregulating related genes. Adding safeners to herbicides is a means of artificially giving herbicides selectivity to improve crop resistance. Its role also includes selective herbicide synergists to expand the weed control spectrum of herbicides without increasing herbicide damage to crops. There are more than 30 varieties of herbicide safeners and their commercial compositions with herbicides that have been put into production practice to protect rice, wheat, corn, sorghum and other gramineous crops, soybeans, cotton and other broad-leaved crops.

[0004] The technical problems that need to be solved urgently in the field of herbicides are to select different crops at different growth stages, the types of weeds in special growth stages, and the sensitivity of plants to different herbicides, screen the herbicides and safeners available in the prior art, and obtain the optimal combination and relative proportion in order to apply them to specific crops. Summary of the invention

[0005] p-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is one of the most important herbicide targets. HPPD-inhibiting herbicides inhibit the activity of HPPD, which blocks the process of converting p-hydroxyphenylpyruvate into homogentisate, thereby affecting the synthesis of plastoquinone and tocopherol in plants, causing the plants to develop albinism symptoms and die. This type of herbicide has the advantages of high efficiency, low toxicity, broad weed control spectrum, and slow development of resistance.

[0006] The present invention aims at the deficiencies in the prior art and provides a herbicidal composition for gramineous crops, wherein the composition can be used to control weeds in gramineous crops; the herbicidal composition comprises a para-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor and a safener having a structure as described in formula (1):

[0007] Wherein R is selected from one of hydrogen, C1-C8 alkyl, C1-C8 alkoxy, hydroxyl, halogen, nitro and phenyl.

[0008] Furthermore, the present invention provides a herbicidal composition for gramineous crops as described above, wherein the selected cereals are preferably one or more of wheat, rice or millet; more preferably wheat.

[0009] Furthermore, the present invention provides the herbicidal composition for gramineous crops as described above, wherein R is selected from one of C2-C7 alkyl, nitro and phenyl; preferably, R is selected from n-pentyl.

[0010] Furthermore, the present invention provides the herbicidal composition for gramineous crops as described above, wherein R is selected from n-pentyl.

[0011] Furthermore, the present invention provides a herbicidal composition for gramineous crops as described above, wherein the mass ratio of the safener active ingredient to the herbicide active ingredient is 1:(0.7-70.0), preferably 1:(2-60.0), more preferably 1:(5-40.0), and most preferably 1:10 or 1:30.

[0012] Furthermore, the present invention provides a herbicidal composition for gramineous crops as described above, wherein the p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor is selected from at least one of isoxathiapiprolin, benomyl, thiamethoxam, and cypermethrin, preferably benomyl.

[0013] Furthermore, the present invention provides a herbicide composition for gramineous crops as described above, wherein the herbicide composition further comprises other herbicides, and preferably the other herbicides are selected from one or more of clofopyralid, 2-Methyl-4-chloro-sodium, mesotrione, bispyribac, and isoproturon.

[0014] Furthermore, the present invention provides a herbicide composition for gramineous crops as described above, wherein the herbicide composition is compounded with clofopyralid and used for post-emergence control of annual broad-leaved weeds such as shepherd's purse, sophora flavescens, veronica, and pigweed in wheat fields, wherein the ratio of the HPPD inhibitor to clofopyralid is 1:(0.5-50), preferably 1:(1-40), more preferably 1:(3-20), and most preferably 1:5.

[0015] Furthermore, the present invention provides a herbicide composition for gramineous crops as described above, wherein the herbicide composition is compounded with sodium 2-methyl-4-chloropropene and is used for post-emergence control of annual broad-leaved weeds such as shepherd's purse, sophora flavescens, veronica officinalis, and pigweed in wheat fields, wherein the mass ratio of the p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor to sodium 2-methyl-4-chloropropene is 1:(1-100), preferably 1:(5-80), more preferably 1:(10-40), and most preferably 1:30.

[0016] Furthermore, the present invention provides a herbicide composition for gramineous crops as described above, wherein the herbicide composition is compounded with mesotrione and is used for post-emergence control of annual broad-leaved weeds such as shepherd's purse, sophora flavescens, veronica, and pigweed in wheat fields, wherein the mass ratio of the p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor to mesotrione is 1:(0.1-10), preferably 1:(0.2-5), more preferably 1:(0.8-2), and most preferably 1:1.

[0017] Furthermore, the present invention provides a herbicide composition for gramineous crops as described above, wherein the herbicide composition is compounded with florasulam and is used for post-emergence control of annual broad-leaved weeds such as shepherd's purse, sophora flavescens, veronica persica and pigweed in wheat fields, wherein the mass ratio of the p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor to florasulam is 1:(0.01-1), preferably 1:(0.02-0.5), more preferably 1:(0.05-0.2), and most preferably 1:0.1.

[0018] Furthermore, the present invention provides a herbicide composition for gramineous crops as described above, wherein the herbicide combination is compounded with isoproturon and is used for post-emergence control of annual gramineous weeds such as Alopecurus japonicus, Alopecurus japonicus and Bromus striata in wheat fields, wherein the mass ratio of the p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor to isoproturon is 1:(2-200), preferably 1:(10-100), more preferably 1:(5-50), and most preferably 1:7.33.

[0019] Furthermore, the present invention provides use of the herbicidal composition as described above in controlling weeds in gramineous crops, wherein the gramineous crops are preferably selected from one or more of wheat, rice or millet, more preferably wheat.

[0020] The composition of the present invention preferably further comprises an agriculturally acceptable carrier. The composition of the present invention can be formulated into granules, wettable granules, emulsifiable concentrates, powders or dusts, liquids, solutions, suspensions or emulsions, or controlled release forms such as microcapsules.

[0021] Wettable powders are in the form of finely divided particles that are easily dispersed in water or other liquid carriers. The particles contain the active ingredient retained in a solid matrix. Typical solid matrices include Fuller's earth, kaolin, silica, and other easily wetted organic or inorganic solids. Wettable powders generally contain from about 5% to about 95% active ingredient plus a small amount of a wetting agent, dispersant or emulsifier.

[0022] Emulsifiable concentrates are uniform liquid compositions that can be dispersed in water or other liquids. They can be composed entirely of active ingredients and liquid or solid emulsifiers, and can also contain liquid carriers such as xylene, heavy aromatic naphtha, isophorone and other non-volatile organic solvents. When used, these concentrates are dispersed in water or other liquids and usually applied to the area to be treated by spraying. The amount of active ingredient can be from about 0.5% to about 95% of the concentrate.

[0023] Granules include extrudates and coarser particles and are usually applied undiluted to the area where it is desired to inhibit plant growth. Typical carriers for granules include sand, bleaching powder, attapulgite, bentonite, montmorillonite, vermiculite, perlite and other organic or inorganic materials that can absorb or be coated with the active ingredient. Granules generally contain from about 5% to about 95% active ingredient and may contain surfactants such as heavy aromatic naphtha, kerosene and other petroleum fractions or vegetable oils; and / or binders such as dextrins, glues or synthetic resins.

[0024] Dusts are free-flowing mixtures of the active ingredient with finely divided solids such as talc, clays, flours and other organic and inorganic solids which act as dispersants and carriers.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. The herbicide safener containing quinoline structure, clofos-butyl, is used to protect gramineous grains from the damage caused by the HPPD herbicide benomyl. It can reduce the damage caused by the herbicide to crops without affecting the efficacy of the herbicide. The combination of clofos-butyl and benomyl is used for weeding gramineous grains such as wheat, rice, and millet. It has excellent weed control ability and can protect crops from damage.

[0027] 2. The compound herbicide combination of a quinoline-containing herbicide safener and an HPPD herbicide fenpyroxetine described in the present invention is feasible. On the basis of being safe for wheat, rice and millet, the effect of alleviating the phytotoxicity of HPPD herbicides on wheat is far better than that on rice and millet, which indicates that the compound herbicide of the present invention has achieved unexpected technical effects in the field of wheat weed control.

[0028] Instruction Manual

[0029] Figure 1 This is a safety test of different concentrations of benomyl on wheat;

[0030] Figure 2 The feasibility of the combination of quinoline-containing herbicide safener chlorfenapyr and HPPD-type herbicide fenpyroxetine was verified;

[0031] Figure 3-Figure 4 The efficacy test of the combination of quinoline-containing herbicide safener chlorfenapyr and HPPD-type herbicide fenpyroxetine and different treatment groups of Artemisia selengensis was verified;

[0032] Figure 5-Figure 6 The efficacy test of the combination of quinoline-containing herbicide safener chlorfenapyr and HPPD-type herbicide fenpyroxetine on shepherd's purse in different treatment groups was verified;

[0033] Figure 7 Comparison of details of individual plants in different mixed treatments (1. Blank control 2. Bifenazolin + clofopyralid 3. Mefenazolin alone 4. Mefenazolin + bispyribac 5. Mefenazolin + clofopyralid 6. Mefenazolin + 2-Methyl-4-chloro-sodium);

[0034] Figure 8-Figure 9 The combination of quinoline-containing herbicide safener chlorfenapyr and HPPD-type herbicide fenpyroxetine was tested for the efficacy of Veronica officinalis in different treatment groups. DETAILED DESCRIPTION

[0035] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0036] The product used in the embodiment of the present invention, in addition to the raw materials, active ingredients and / or safeners, also contains 85% dimethyltetrachlor sodium EP, 20% clofopyralid AS, 5% bispyribac SC, 10% mesotrione EP, 5.5% mesotrione SC+16.5% clofopyralid SC, 22% isoproturon EP, and 6% cypermethrin OD.

[0037] The information of some preparations of the present invention is as follows:

[0038] 30% Mefenacet SC: Mefenacet technical drug 30%, fatty alcohol polyoxyethylene ether phosphate 3%, tristyrylphenol polyoxyethylene ether 3%, nonylphenol polyoxyethylene ether 1%, magnesium aluminum silicate 1.5%, xanthan gum 0.1%, sodium sulfite 0.3%, ethylene glycol 5%, kason 0.1%, silicone defoamer 0.3%, water to make up 100%.

[0039] 20% fluroxypyra AS: fluroxypyra 20%, fatty alcohol polyoxyethylene ether 5%, ethylene glycol 5%, silicone defoamer 0.2%, water to make up 100%.

[0040] 5% florasulam SC: florasulam 5%, fatty alcohol polyoxyethylene ether phosphate 3%, calcium dodecylbenzene sulfonate 2%, magnesium aluminum silicate 2.5%, xanthan gum 0.2%, ethylene glycol 5%, kason 0.1%, silicone defoamer 0.3%, water to make up 100%.

[0041] 10% Mesotrione EP: Mesotrione 10%, silicone 2%, white carbon 20%, calcium lignin sulfonate 10%, maleic acid-sodium acrylate 2%, sodium gluconate 100%.

[0042] 85% dimethyltetrachlorosodium SP: dimethyltetrachlorosodium 85%, naphthalenesulfonate formaldehyde condensate 8%, sodium dodecylbenzenesulfonate 2%, white carbon black 100%.

[0043] 22% Isoproturon EP: Isoproturon 22%, acrylic acid methacrylate copolymer 8%, fatty alcohol polyoxyethylene ether 3%, white carbon black 10%, sodium lignin sulfonate 10%, ammonium sulfate 100%.

[0044] For the finished products not mentioned here, when the API and preparation types are the same but the contents are different, the content shall be adjusted according to the specific active ingredient content, and other excipients shall be adaptively adjusted; other finished products not mentioned are all commercially available products, and they shall be diluted with water according to the dosage before use and experimentation.

[0045] The following examples are only descriptive, not definitive, and protection scope of the present invention can not be limited to this. The endpoints and any value of the scope disclosed in this article are not limited to this accurate scope or value, and these scopes or values ​​should be understood as comprising values ​​close to these scopes or values. For numerical ranges, between the endpoint values ​​of each scope, between the endpoint values ​​of each scope and a separate point value, and between the separate point value, can be combined with each other to obtain one or more new numerical ranges, and these numerical ranges should be considered as specifically disclosed in this article.

[0046] Example 1 Study on the safety of HPPD herbicides benzathine to indoor wheat and the effects of different herbicide safeners on the alleviation of indoor wheat damage to HPPD herbicides benzathine

[0047] In order to study the safety of HPPD herbicide benzathone on wheat and the effects of different safeners on the alleviation of pesticide damage, 800 pots of wheat were planted in the greenhouse of Pangjia Biotest Base of Shandong Jingbo Agrochemical Technology Co., Ltd., with no less than 50 seeds sown in each pot, and the management of the 800 pots of wheat was the same. 495 pots of plants with similar growth during the growth period were selected as test objects; they were used for the safety test of HPPD herbicide benzathone on indoor wheat and the effects of different herbicide safeners on the alleviation of pesticide damage of indoor wheat against HPPD herbicides benzathone.

[0048] 1. Safety test of HPPD herbicide fenpyroxetine on indoor wheat:

[0049] In order to study the safety of HPPD herbicide benzathine on indoor wheat, benzathine was diluted twice, and the treatment area was selected. Water was added to the sample, and after dilution and mixing, it was introduced into the sprayer and supplemented according to the water consumption of the plot. The dosage of the active ingredient was 9.00g / hectare, 13.50g / hectare, 18.00g / hectare, 22.50g / hectare, 27.00g / hectare, 31.50g / hectare, 36.00g / hectare, 54.00g / hectare, and 81.00g / hectare. The 120 pots of wheat selected as the test objects were divided into 8 groups (treatments 1-8), with 5 pots in each group, and repeated three times. During the wheat growth period, the potted wheat was sprayed by stem and leaf spray. The test results were investigated on the 14th day, and the inhibition rate of fresh weight / plant height content of each treatment was calculated according to the formula. The calculation results were retained to two decimal places. The results are shown in Table 1. Figure 1 shown.

[0050]

[0051] Where:

[0052] R—growth inhibition rate, in percentage (%);

[0053] X0—control fresh weight (or plant height), in grams or centimeters (g or Cm);

[0054] X1—treated fresh weight (or plant height), in grams or centimeters (g or cm).

[0055] Table 1 Safety test of different concentrations of benomyl on wheat

[0056]

[0057] The results showed that when the HPPD herbicide benzathine was used on wheat at an active ingredient content of 18g / hectare or above, it would cause phytotoxicity to wheat, affecting the plant height growth rate and fresh weight inhibition rate of wheat.

[0058] 2. Study on the effect of different herbicide safeners on the harm of indoor wheat resistant to HPPD herbicides fenacet:

[0059] In order to study the effect of different herbicide safeners on the phytotoxicity mitigation of indoor wheat resistant to HPPD herbicides, benzathone was used for secondary dilution, the treatment area agent was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer, supplemented by the water consumption of the plot, and configured to be 18.00g / hectare, 27.00g / hectare, 36.00g / hectare, 54.00g / hectare, 81.00g / hectare. Safener was added during the configuration process, and the mass ratio of the active ingredient of the herbicide safener to the active ingredient of the herbicide was 1:10. The 375 pots of wheat potted plants selected as the test objects were divided into 25 groups (treatment 9-33), 5 pots per group, and repeated three times. During the wheat growth period, potted wheat was sprayed by means of stem and leaf spraying. The statistical method of the results is shown in Example 1, and the results are shown in Table 2.

[0060] Table 2 Comparative test on the effect of different herbicide safeners on the alleviation of indoor wheat resistant to HPPD herbicide benomyl

[0061]

[0062]

[0063] The results showed that the effects of different safeners on alleviating wheat phytotoxicity varied greatly. Among them, the herbicide safener chlorfenapyr containing a quinoline structure had the greatest protective effect. When the mass ratio of the active ingredient of the herbicide safener to the active ingredient of the herbicide was 1:10, there was no significant difference in the indicators of wheat and the control group.

[0064] Example 2: Study on the effect of different concentrations of quinoline-containing herbicide safener clofazoline on indoor wheat resistance to HPPD herbicide fenacet-butyl:

[0065] In order to study the effect of different concentrations of quinoline-containing herbicide safener cypermethrin on the phytotoxicity of indoor wheat against HPPD herbicide benzaclodomycin, benzaclodomycin was diluted by the secondary dilution method, the treatment area was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer. The amount of active ingredient was supplemented according to the water consumption of the plot, and the amount of active ingredient was configured to be 18.00g / ha, 27.00g / ha, and 36.00g / ha. The mass ratio of the active ingredient of the herbicide safener to the active ingredient of the herbicide was 3 low, medium and high levels, namely 1:10, 1:20, and 1:30. 200 pots of wheat were planted in the greenhouse, and each pot of wheat was sown with no less than 50 grains. During the wheat growth period, 180 pots of wheat with similar growth were selected and divided into 12 groups, with 5 pots in each group, and repeated three times. The potted wheat was sprayed by stem and leaf spray. The test results were investigated on the 14th day, and the inhibition rate of fresh weight / plant height content of each treatment was calculated according to the formula. The calculation results were retained to two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 3.

[0066] Table 3 Comparison of different concentrations of chlorpyrifos-butyl in alleviating wheat phytotoxicity

[0067]

[0068] The results showed that low, medium and high concentrations of quinoline-containing herbicide safeners cloquinoline-butyl can protect wheat to a certain extent, and when the concentration of benzathone is low, there is no significant difference in the mitigation effect of the three concentrations of cloquinoline-butyl. When mixed with low concentration of benzathone (active ingredient less than 27 g / hectare), the optimal ratio of cloquinoline-butyl to benzathone active ingredient is 1:30; if mixed with high concentration of benzathone (active ingredient higher than 27 g / hectare), the optimal ratio of cloquinoline-butyl to benzathone active ingredient is 1:10

[0069] Example 3: Study on the effect of quinoline-containing herbicide safener clofosbumid on wheat fields in major wheat producing areas against the HPPD herbicide fenamidazole

[0070] In order to study the effect of quinoline-containing herbicide safener chlorfenapyr on wheat resistance to HPPD herbicide benzathine in the main wheat producing areas, benzathine was diluted by the secondary dilution method, the treatment area agent was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and the effective ingredient dosage was configured to be 18.00g / hectare and 27.00g / hectare. The mass ratio of the active ingredient of the herbicide safener to the active ingredient of the herbicide was 1:30. The test was carried out in Fugou County, Henan Province, Taihe County, Anhui Province, Lianshui County, Jiangsu Province, and Tancheng County, Shandong Province, the main wheat producing areas, 20 square meters per treatment, and each treatment was repeated 3 times. During the wheat growth period, wheat was sprayed by stem and leaf spraying. On the 14th day, the test results were investigated and the inhibition rate of the fresh weight / plant height content of each treatment was calculated by formula. The calculation results retained two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 4.

[0071] Table 4 Comparison of the effect of chlorpyrifos in alleviating wheat damage in different regions

[0072]

[0073] The results showed that experiments conducted in major wheat producing areas across the country found that the herbicide safener quinoline-containing chlorpyrifos-butyl had a significant protective effect on wheat.

[0074] Example 4: Experimental study on the efficacy of a quinoline-containing herbicide safener clofazoline-butyl and an HPPD-type herbicide fenpyroxetine on weeds in wheat fields in major wheat-producing areas

[0075] In order to study whether the addition of chlorfenapyr will affect the efficacy of fenpyroxetine, fenpyroxetine was diluted by the secondary dilution method, the treatment area agent was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and configured to an effective ingredient dosage of 27.00 g / hectare. The mass ratio of the active ingredient of the herbicide safener to the active ingredient of the herbicide was 1:30. The test was carried out in Taihe County, Anhui Province, with 20 square meters for each treatment and 3 repetitions for each treatment. During the wheat growth period, Artemisia sophora japonica, Veronica oleracea, and Shepherd's purse were sprayed by stem and leaf spraying. On the 14th day, the test results were investigated and the plant prevention effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retained two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 5.

[0076] Table 5 Feasibility verification of a combination of a quinoline-containing herbicide safener chlorfenapyr and an HPPD-type herbicide fenpyroxetine

[0077]

[0078] The results show that when the herbicide safener containing quinoline structure is added, the HPPD herbicide fenpyroxetine has no significant effect on the efficacy of the main weeds in the wheat field, such as Artemisia sophora flavescens, Veronica officinalis, Shepherd's purse, and Pigweed. Therefore, the herbicide combination agent of the herbicide safener containing quinoline structure and the HPPD herbicide fenpyroxetine is feasible.

[0079] Example 5: Results of efficacy test of a combination of a quinoline-containing herbicide safener, fenpyrot-butyl, an HPPD-type herbicide, and clofopyralid on annual broadleaf weeds.

[0080] In order to study the efficacy test results of the combination agent on annual broad-leaved weeds, the treatment area agent was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and configured to be 27.00g / hectare of the active ingredient. The mass ratio of clofoscar to the active ingredient of benzathine is 1:30, and the mass ratio of benzathine to clofoscar is 1:5. The test was carried out in Taihe County, Anhui Province, each treatment was 20 square meters, and each treatment was repeated 3 times. During the wheat growth period, Artemisia sophora japonica, Veronica officinalis, Shepherd's purse, and pig seedlings were sprayed by stem and leaf spraying. On the 14th day, the test results were investigated, and the plant prevention effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retain two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 6.

[0081] Table 6 The results of the efficacy test of a quinoline-containing herbicide safener chlorpyrifos, an HPPD-type herbicide fenpyraclostrobin and clofopyralid on different broadleaf weeds in wheat fields

[0082]

[0083] The results showed that the combination of a quinoline-containing herbicide safener cypermethrin, HPPD-type herbicide benomyl and clofopyralid significantly improved the plant control efficacy and fresh weight inhibition rate on Artemisia sophora, Shepherd's purse and pigweed seedlings compared with single-dose benomyl and clofopyralid.

[0084] Example 6: Efficacy test results of a combination of a quinoline-containing herbicide safener clofodim, an HPPD-type herbicide fenpyroxetine and 2-Methyl-4-chloro-1-sodium on annual broadleaf weeds

[0085] In order to study the efficacy test results of the combination agent on annual broad-leaved weeds, the treatment area agent was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and the effective ingredient dosage was configured to be 27.00g / hectare. The mass ratio of clofoscar to the active ingredient of benzathine is 1:30, and the mass ratio of benzathine to 2-methyl-4-chloro-sodium is 1:30. The test was carried out in Taihe County, Anhui Province, with 20 square meters for each treatment and 3 times for each treatment. During the wheat growth period, Artemisia sophora japonica, Veronica officinalis, and Shepherd's purse were sprayed by stem and leaf spraying. On the 14th day, the test results were investigated and the plant prevention effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retain two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 7.

[0086] Table 7 The results of the efficacy test of a quinoline-containing herbicide safener chlorfenapyr, an HPPD-type herbicide fenpyroxil and 2-Methyl-4-chloro-sodium on different broad-leaved weeds in wheat fields

[0087]

[0088] The results showed that the combination of a quinoline-containing herbicide safener chlorpyrifos-butyl, an HPPD-type herbicide fenpyroxetine and 2-Methyl-4-chloro-sodium significantly improved the plant control efficacy and fresh weight inhibition rate on Artemisia selengensis, Shepherd's purse and pigweed seedlings compared with single-dose fenpyroxetine and single-dose 2-Methyl-4-chloro-sodium.

[0089] Example 7: Efficacy test results of a quinoline-containing herbicide safener clofosinate, an HPPD-type herbicide fenpyroxetine and a combination of mesotrione and foramsulfuron against annual broadleaf weeds

[0090] In order to study the efficacy test results of the combination agent on annual broad-leaved weeds, the treatment area agent was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and the effective ingredient dosage was configured to be 27.00g / hectare. The mass ratio of clofosbumid to the active ingredient of benzathine is 1:30, and the mass ratio of benzathine to benzathine is 1:1. The test was carried out in Taihe County, Anhui Province, with 20 square meters for each treatment and 3 times for each treatment. During the wheat growth period, Artemisia sophora japonica, Veronica officinalis, and Shepherd's purse were sprayed by stem and leaf spraying. On the 14th day, the test results were investigated and the plant prevention effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retain two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 8.

[0091] Table 8 Efficacy test results of a quinoline-containing herbicide safener chlorfenapyr, HPPD-type herbicides fenpyroxil and foramsulfuron combined agent on different broadleaf weeds in wheat fields

[0092]

[0093] The results show that if foramsulfuron is used irrationally on wheat, it is easy to cause phytosanitary damage, but it has a strong efficacy itself. After being mixed with benzathine, it has excellent control effect on common broad-leaved weeds in wheat fields. A combination of a quinoline-containing herbicide safener cypermethrin, an HPPD herbicide benzathine and foramsulfuron can be used to control broad-leaved weeds in wheat fields with high resistance.

[0094] Example 8: Efficacy test results of a combination of a quinoline-containing herbicide safener clofosbumid, an HPPD-type herbicide fenamidoprop-butyl and bispyribac on annual broadleaf weeds

[0095] In order to study the efficacy test results of the combination agent on annual broad-leaved weeds, the treatment area agent was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and the effective ingredient dosage was configured to be 27.00g / hectare. The mass ratio of clofoscar to the active ingredient of benzathine is 1:10, and the mass ratio of benzathine to bispyribac is 1:0.1. The test was carried out in Taihe County, Anhui Province, with 20 square meters for each treatment and 3 times for each treatment. During the wheat growth period, Artemisia sophora, Veronica officinalis, and Shepherd's purse were sprayed by stem and leaf spraying. On the 14th day, the test results were investigated, and the plant prevention effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retain two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 9.

[0096] Table 9 Efficacy test results of a quinoline-containing herbicide safener fenpyroxetine, HPPD herbicide benzathine and bispyribac on different broadleaf weeds in wheat fields

[0097]

[0098]

[0099] The results showed that the combination of a quinoline-containing herbicide safener cypermethrin, HPPD-type herbicides benomyl and bispyribac significantly improved the plant control efficacy and fresh weight inhibition rate on Veronica ovata and pigweed seedlings compared with single-dose benomyl and bispyribac.

[0100] Example 9: Results of the efficacy test of a combination of a quinoline-containing herbicide safener, chlorfenapyr, an HPPD-type herbicide, and isoproturon on brome.

[0101] In order to study the efficacy test results of the combination agent on annual grass weeds, the treatment area agent was selected, water was added to the sample, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and the active ingredient dosage was configured to be 27.00g / hectare. The mass ratio of chlorpyrifos to the active ingredient of benzathine is 1:30, and the mass ratio of benzathine to isoproturon is 1:27.5. The test was carried out in Tancheng County, Shandong Province, with 20 square meters per treatment and 3 replicates per treatment. During the wheat growth period, brome was sprayed by stem and leaf spraying. On the 14th day, the test results were investigated, and the plant protection effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retain two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 10.

[0102] Table 10 Results of the efficacy test on old bromegranates by using a quinoline-containing herbicide safener, fenpyroxetine, HPPD-type herbicides fenpyroxetine and isoproturon

[0103]

[0104] The results showed that a combination of a quinoline-containing herbicide safener, cypermethrin, an HPPD-type herbicide, and isoproturon had a certain effect on the control of older bromegrass, and that the efficacy of cypermethrin was not inferior to that of cypermethrin at the same dosage of the active ingredient.

[0105] Example 10: Results of efficacy test of a combination of a quinoline-containing herbicide safener clofosbumid, an HPPD-type herbicide fenamidoprop-butyl and isoproturon on Japanese alopecuroides.

[0106] In order to study the efficacy test results of the combination agent on annual grass weeds, the treatment area agent was selected, water was added to the sample, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and the active ingredient dosage was configured to be 27.00g / hectare. The mass ratio of chlorpyrifos to the active ingredient of benzathine is 1:30, and the mass ratio of benzathine to isoproturon is 1:27.5. The test was carried out in Lianshui County, Jiangsu Province, with 20 square meters per treatment and 3 repetitions for each treatment. During the wheat growth period, Japanese foxtail was sprayed by stem and leaf spraying. On the 14th day, the test results were investigated, and the plant protection effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retain two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 11.

[0107] Table 11 Results of the efficacy test on Japanese alopecuroides by using a quinoline-containing herbicide safener, fenpyroxetine, HPPD-type herbicides, fenpyroxetil and isoproturon

[0108]

[0109] Example 11: Results of efficacy tests on bromustine, a quinoline-containing herbicide safener, and the HPPD-type herbicides fenpyroxil and isoproturon.

[0110] In order to study the efficacy test results of the combination agent on annual broad-leaved weeds, the treatment area agent was selected, water was added to the sample, diluted and mixed, and then introduced into the sprayer, supplemented according to the water consumption of the plot, and the effective ingredient dosage was configured to be 27.00g / hectare. The mass ratio of chlorpyrifos to the active ingredient of benzathine is 1:10, and the mass ratio of benzathine to isoproturon is 1:18.33, 1:9.17, and 1:7.33. The test was carried out in Boxing County, Shandong Province, with 20 square meters for each treatment and 3 replicates for each treatment. During the wheat growth period, brome was sprayed by stem and leaf spraying. On the 14th day, the test results were investigated, and the plant protection effect and fresh weight inhibition rate of each treatment were calculated according to the formula. The calculation results retain two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 12.

[0111] Table 12 Results of the efficacy test on bromegranate of a combination of a quinoline-containing herbicide safener cypermethrin, an HPPD-type herbicide fenamidoprop-butyl and isoproturon.

[0112]

[0113] The results showed that a quinoline-containing herbicide safener, fenpyraclostrobin, an HPPD-type herbicide, and a combination of isoproturon had a certain effect on the control of Japanese alopecuroides. The activity of fenpyraclostrobin was stronger than that of cypermethrin. Both single use and combination use had a good control effect on bromegrass, proving the feasibility of using fenpyraclostrobin for grass weeds in wheat fields.

[0114] Example 12: Study on the effect of different concentrations of quinoline-containing herbicide safener clofosbumid on indoor rice resistance to HPPD herbicide fenamiprolin:

[0115] In order to study the effect of different concentrations of quinoline-containing herbicide safener cypermethrin on the resistance of indoor rice to HPPD herbicide benzaclodomycin, benzaclodomycin was diluted by the secondary dilution method, the treatment area was selected, the sample was added with water, diluted and mixed, and then introduced into the sprayer. The amount of active ingredient was supplemented according to the water consumption of the plot, and the amount of active ingredient was configured to be 18.00g / ha, 27.00g / ha, and 36.00g / ha. The mass ratio of the active ingredient of the herbicide safener to the active ingredient of the herbicide was 3 low, medium and high levels, namely 1:10, 1:20, and 1:30. 200 rice pots were planted in the greenhouse, each pot was sown with no less than 50 rice seeds, and divided into 12 groups, each group with 5 pots, and repeated three times. During the growth period of rice, potted sorghum was sprayed by stem and leaf spray. The test results were investigated on the 14th day, and the inhibition rate of fresh weight / plant height content of each treatment was calculated according to the formula. The calculation results were retained to two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 13.

[0116] Table 13 Comparison of different concentrations of chlorpyrifos-butyl in alleviating rice damage

[0117]

[0118]

[0119] The results showed that low, medium and high concentrations of the quinoline-containing herbicide safener cypermethrin had a certain effect on alleviating the phytosan damage of rice, but the effect was general.

[0120] Example 13: Study on the effect of different concentrations of quinoline-containing herbicide safener clofosbumid on indoor millet resistance to HPPD herbicide fenamidazole:

[0121] In order to study the effect of different concentrations of quinoline-containing herbicide safener chlorfenapyr on the phytotoxicity of indoor millet against the HPPD herbicide fenpyroxetate, fenpyroxetate was used for the second dilution method. The treatment area was selected, and the sample was added with water. After dilution and mixing, it was introduced into the sprayer and supplemented according to the water consumption of the plot. The active ingredient dosage was 18.00 g / ha, 27.00 g / ha, and 36.00 g / ha. The mass ratio of the active ingredient of the herbicide safener to the active ingredient of the herbicide was 3 low, medium, and high levels, namely 1:10, 1:20, and 1:30. 200 pots of millet were planted in the greenhouse, with no less than 50 grains sown in each pot, divided into 12 groups, 5 pots in each group, and repeated three times. During the growth period of millet, the potted millet was sprayed by stem and leaf spray. The test results were investigated on the 14th day, and the inhibition rate of fresh weight / plant height content of each treatment was calculated according to the formula. The calculation results were retained to two decimal places. The statistical method of the results is shown in Example 1, and the test results are shown in Table 14.

[0122] Table 14 Comparison of different concentrations of chlorpyrifos in alleviating the phytotoxicity of millet

[0123]

[0124]

[0125] The results showed that low, medium and high concentrations of quinoline-containing herbicide safener chlorpyrifos-butyl could protect millet to a certain extent.

[0126] In summary, the herbicide safener containing quinoline structure can alleviate the phytotoxicity of HPPD herbicides to cereal crops, such as wheat, rice and millet, and the effect of alleviating the phytotoxicity of HPPD herbicides to wheat is particularly significant. When the mass ratio of the active ingredients is 1:(0.7-70.0), the herbicide safener containing quinoline structure and the HPPD herbicide fenpyroxetamide compound herbicide combination agent of the present invention is feasible, and on the basis of being safe for wheat, rice and millet, it will not affect the efficacy.

[0127] Furthermore, the present invention describes its related compound formula and test results, proving its feasibility in specific situations. The effect of clofabutin-mexyl on alleviating the HPPD herbicide damage to wheat is much better than that to rice and millet, which may be related to the interaction between the target and the crop.

[0128] Although the embodiments of the present invention are disclosed for illustrative purposes, within the technical concept of the present invention, a variety of simple modifications may be made to the technical solution of the present invention, including combining various technical features in any other suitable manner, and these simple modifications and combinations shall also be regarded as the contents disclosed by the present invention and belong to the protection scope of the present invention. Various substitutions, changes and modifications are possible without departing from the spirit and scope of the present invention and the appended claims, and therefore, the scope of the present invention is not limited to the contents disclosed by the embodiments.

Claims

1. A herbicidal composition for gramineous crops, characterized in that: The herbicidal composition comprises a para-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor and a safener having the structure of formula (1): Wherein, R is selected from one of hydrogen, C1-C8 alkyl, C1-C8 alkoxy, hydroxyl, halogen, nitro and phenyl.

2. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The gramineous cereals are selected from one or more of wheat, rice or millet.

3. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The R is selected from one of C2-C7 alkyl, nitro and phenyl; preferably, the R is selected from n-pentyl.

4. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The mass ratio of the safener to the HPPD inhibitor is 1:(0.7-70.0), preferably 1:(2-60.0), more preferably 1:(5-40.0), and most preferably 1:30 or 1:

10.

5. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor is selected from at least one of isoxathiapiprolin, benomyl, thiamethoxam, and thiamethoxam, preferably benomyl.

6. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The herbicide composition further comprises other herbicides. Preferably, the other herbicides are selected from one or more of clofopyralid, 2-Methyl-4-chloro-sodium, mesotrione, bispyribac and isoproturon.

7. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The herbicide composition is further compounded with clofopyralid, and the ratio of the HPPD inhibitor to clofopyralid is 1:(0.5-50), preferably 1:(1-40), more preferably 1:(3-20), and most preferably 1:

5.

8. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The herbicide composition is further compounded with 2-methyl-4-chloro-sodium, and the mass ratio of the p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor to 2-methyl-4-chloro-sodium is 1:(1-100), preferably 1:(5-80), more preferably 1:(10-40), and most preferably 1:

30.

9. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The herbicide composition is further compounded with mesotrione, and the mass ratio of the HPPD inhibitor to mesotrione is 1:(0.1-10), preferably 1:(0.2-5), more preferably 1:(0.8-2), and most preferably 1:

1.

10. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The herbicide composition is further compounded with bispyribac, and the mass ratio of the para-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor to bispyribac is: 1: (0.01-1), preferably 1: (0.02-0.5), more preferably 1: (0.05-0.2), and most preferably 1: 0.

1.

11. The herbicidal composition for gramineous crops according to claim 1, characterized in that: The herbicide combination is further compounded with isoproturon, and the mass ratio of the p-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor to isoproturon is: 1: (2-200), preferably 1: (10-100), more preferably 1: (30-50), and most preferably 1: 7.

33.

12. Use of the herbicidal composition according to claim 1 in controlling weeds in gramineous crops, wherein the gramineous crops are preferably selected from one or more of wheat, rice or millet, more preferably wheat.

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