Establishment method of permanent cerebral ischemia model of eastern vole

By bluntly separating the neck muscle groups and nylon thread plugging into the middle artery in oriental voles, problems such as difficulty in operation and high mortality in the construction of existing rat cerebral ischemia models were solved, and a stable and low mortality cerebral ischemia model was successfully established, providing a new tool for stroke research.

CN119700361APending Publication Date: 2025-03-28SHANGHAI RES CENT FOR MODEL ORGANISMS
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Patent Information

Application Number
CN202411982311.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-31
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The existing rat cerebral ischemic model has problems such as difficulty in operation, high mortality rate, large surgical trauma, and poor model stability and reproducibility during the construction process.

Method used

Oriental voles were used as model animals to bluntly separate the neck muscles, expose the bifurcation of common carotid artery, internal carotid artery and external carotid artery, and block the anterior end of the middle artery using 0.22±0.02mm nylon thread plug to establish a permanent cerebral ischemia model.

Benefits of technology

A permanent cerebral ischemic model of Oriental voles with stable infarction volume, low mortality rate and uniform cerebral infarction range was successfully established, providing a more reliable and effective animal model for stroke-related research.

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Abstract

The invention belongs to the technical field of animal model construction, and relates to a method for establishing an oriental vole permanent cerebral ischemia model. A nylon wire bolt with the head end diameter of 0.22 + / -0.02 mm is used, a mark is made at the position, 1.5 cm away from the head end, of the wire bolt, the wire bolt is inserted through a neck artery wound of the eastern vole and enters the middle artery of the vole brain through the internal carotid artery, and therefore the front end of the middle artery is blocked, and the vole permanent cerebral ischemia model is completed. The permanent cerebral ischemia model of the oriental vole is successfully established. The model has the characteristics of stable infarction volume, low death rate and uniform cerebral infarction range, and provides a more reliable and effective animal model for stroke related research.
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