Antioxidant whitening composition, cosmetics and their preparation methods

Abstract

This application relates to the field of cosmetic technology, specifically to an antioxidant whitening composition, a cosmetic product, and a method for preparing the same. When the antioxidant whitening composition includes two of gallic acid, proanthocyanidins, or rutin, the mass ratio of any two raw materials is (1-3):(1-3); and / or when the antioxidant whitening composition includes three of gallic acid, proanthocyanidins, and rutin, the mass ratio of gallic acid, proanthocyanidins, and rutin in the antioxidant whitening composition is (4-8):(1-3):(1-3). The antioxidant whitening composition achieves a synergistic effect, effectively enhancing the antioxidant effect of the composition, especially significantly improving the ABTS free radical scavenging rate. Simultaneously, the synergistic effect of the various components in the composition also significantly enhances the inhibitory effect on tyrosinase. Applying this antioxidant whitening composition to cosmetics can improve the skin's redox imbalance.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of cosmetics, in particular, relates to an antioxidant whitening composition, cosmetics and a preparation method thereof. BACKGROUND

[0002] Skin is affected by external pollution and internal stress, etc. Factors, active oxygen and free radicals are produced, causing redox state imbalance. Excessive free radicals not only cause cell damage, but also can induce tyrosinase activity, leading to pigment deposition. In addition, free radicals also participate in triggering skin inflammation, inducing a series of skin problems including inflammatory aging, skin sensitivity, fine lines and wrinkles, etc.

[0003] However, there is a lack of natural green skin care products that can improve the redox state imbalance of the skin on the market at present. SUMMARY

[0004] The purpose of the embodiments of the present application is to provide an antioxidant whitening composition and cosmetics.

[0005] In a first aspect, the present application provides an antioxidant whitening composition, which comprises at least two of gallic acid, procyanidin and rutin.

[0006] When the antioxidant whitening composition comprises two of gallic acid, procyanidin or rutin, the mass ratio of any two raw materials is (1-3):(1-3); and / or

[0007] When the antioxidant whitening composition comprises three of gallic acid, procyanidin and rutin, the mass ratio of gallic acid, procyanidin and rutin in the antioxidant whitening composition is (4-8):(1-3):(1-3) by mass ratio.

[0008] In the above technical solution, gallic acid, procyanidin and rutin in the antioxidant whitening composition are all derived from plant secondary metabolites, which are green and natural. By compounding in the above mass ratio range, the components synergize with each other to achieve a synergistic effect, effectively improving the antioxidant effect of the composition, especially the ABTS free radical scavenging rate. At the same time, the synergistic effect of each component in the composition also significantly improves the inhibition effect on tyrosinase; thereby effectively improving the whitening effect of the composition. The antioxidant whitening composition can be applied to cosmetics to improve the redox state imbalance of the skin, effectively improve the problems caused by excessive free radicals, such as cell damage and pigment deposition, caused by the redox state imbalance of the skin.

[0009] Further, the composition provided by the technical scheme of the present application has the advantages that each component is derived from plant secondary metabolites, is green and natural, is more suitable for skin care, has clear efficacy and can synergistically improve the antioxidant whitening effect, is more suitable for industrial production, can greatly enhance the antioxidant whitening effect of the cosmetic when applied to the cosmetic, and meets the market demand for green and natural antioxidant products.

[0010] In other embodiments of the present application, when the antioxidant whitening composition includes three of gallic acid, procyanidine and rutin, the mass ratio of gallic acid, procyanidine and rutin in the antioxidant whitening composition is (5-7):(1.5-2.5):(1.5-2.5) in terms of mass ratio.

[0011] In other embodiments of the present application, when the antioxidant whitening composition includes three of gallic acid, procyanidine and rutin, the mass ratio of gallic acid, procyanidine and rutin in the antioxidant whitening composition is 6:2:2 in terms of mass ratio.

[0012] In other embodiments of the present application, the antioxidant whitening composition includes a gallic acid aqueous solution, a procyanidine aqueous solution and a rutin alkaline solution.

[0013] In other embodiments of the present application, the mass percentage of gallic acid in the gallic acid aqueous solution is 0.005%-0.05% in terms of mass percentage.

[0014] In other embodiments of the present application, the mass percentage of procyanidine in the procyanidine aqueous solution is 0.005%-0.05% in terms of mass percentage.

[0015] In other embodiments of the present application, the rutin alkaline solution includes rutin and a sodium hydroxide aqueous solution.

[0016] The mass percentage of rutin in the rutin alkaline solution is 0.005%-0.05% in terms of mass percentage.

[0017] The mass percentage of sodium hydroxide in the sodium hydroxide aqueous solution is 0.1%-1.5% in terms of mass percentage.

[0018] In a second aspect, the present application provides a cosmetic including the antioxidant whitening composition provided by any of the embodiments of the first aspect.

[0019] In other embodiments of the present application, the addition amount of the antioxidant whitening composition in the cosmetic is 5% or more in terms of mass percentage.

[0020] In other embodiments of the present application, the cosmetic further includes an aqueous phase, an oil phase and optionally a preservative.

[0021] In other embodiments of the present application, the water phase comprises glycerin, butylene glycol, water;

[0022] In other embodiments of the present application, the oil phase comprises sodium hyaluronate, xanthan gum;

[0023] In other embodiments of the present application, the preservative comprises caprylhydroxamic acid, ethylhexylglycerin, 1,2-hexanediol;

[0024] In other embodiments of the present application, the cosmetic comprises, in mass percentage: glycerin 1% to 5%, butylene glycol 4% to 6%, sodium hyaluronate 0.01% to 1.00%, xanthan gum 0.01% to 0.20%, caprylhydroxamic acid 0.010% to 0.030%, ethylhexylglycerin 0.010% to 0.020%, 1,2-hexanediol 0.010% to 0.020%, antioxidant whitening composition 5% to 20%, and deionized water to make up to 100%.

[0025] In other embodiments of the present application, the pH of the cosmetic is 6.5 to 7.5.

[0026] In a third aspect, some embodiments of the present application provide a preparation method of a cosmetic, comprising:

[0027] mixing the oil phase raw materials to obtain an oil phase mixture;

[0028] mixing the water phase raw materials to obtain a water phase mixture;

[0029] mixing and emulsifying the oil phase mixture and the water phase mixture to obtain an emulsified mixture;

[0030] after the emulsified mixture is cooled to below 40℃, adding the antioxidant whitening composition to the emulsified mixture and mixing uniformly;

[0031] Optionally, mixing the oil phase raw materials comprises: dissolving and mixing uniformly the oil phase raw materials at 75℃ to 85℃;

[0032] Optionally, mixing the water phase raw materials comprises: heating and mixing uniformly the water phase raw materials at 75℃ to 85℃;

[0033] Optionally, mixing and emulsifying the oil phase mixture and the water phase mixture comprises: mixing the oil phase mixture and the water phase mixture under stirring at 400 revolutions per minute to 600 revolutions per minute for 5 minutes to 15 minutes for emulsification. BRIEF DESCRIPTION OF DRAWINGS

[0034] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings needed to be used in the embodiments. It should be understood that the following drawings only show some embodiments of the present application, and therefore should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can also be obtained without creative labor.

[0035] Figure 1 The scavenging effect of ABTS free radicals for each example and comparative example;

[0036] Figure 2 The scavenging effect of DPPH free radicals for each example and comparative example;

[0037] Figure 3 The inhibitory effect of tyrosinase for each example and comparative example. DETAILED DESCRIPTION

[0038] In order to make the purposes, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be described clearly and completely. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments.

[0039] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but only represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0040] It is found through research that the application of antioxidants in skin care products can fundamentally solve a variety of skin problems and prevent a series of skin damage caused by free radicals, and has wide applicability. Previous studies have shown that common antioxidants such as vitamin C and vitamin E have good antioxidant capacity and can prevent skin photoaging. However, these antioxidants are not natural and green enough, and long-term use may have other side effects; the market demand for natural antioxidants using plant extracts is increasing.

[0041] However, most plant extracts have complex compositions, unclear efficacy substances, and potential stability, compatibility and allergenicity problems. Based on this, the present application provides a natural skin care composition derived from plant secondary metabolites, which has important significance in that the ingredients have clear efficacy and can synergistically enhance the significant antioxidant and whitening effect.

[0042] The antioxidant and whitening composition provided by the embodiments of the present application comprises at least two of gallic acid, procyanidin and rutin.

[0043] When the antioxidant whitening composition comprises two of gallic acid, procyanidins or rutin, the mass ratio of any two raw materials is (1-3):(1-3); and / or

[0044] When the antioxidant whitening composition comprises three of gallic acid, procyanidins and rutin, the mass ratio of gallic acid, procyanidins and rutin in the antioxidant whitening composition is (4-8):(1-3):(1-3) in terms of mass ratio.

[0045] In the above technical solution, gallic acid, procyanidins and rutin in the antioxidant whitening composition are all derived from plant secondary metabolites, which are green and natural. In the above mass ratio range, the components synergize with each other to achieve a synergistic effect, effectively improving the antioxidant effect of the composition, especially the ABTS free radical scavenging rate. At the same time, the synergistic effect of the components in the composition also significantly improves the inhibition effect on tyrosinase; thereby effectively improving the whitening effect of the composition.

[0046] Further, in the above technical solution, rutin is a natural flavonoid compound with antioxidant, anti-inflammatory, anti-allergic and vascular elasticity enhancing effects. It can reduce skin redness, repair vascular damage and promote blood circulation. However, rutin has very poor water solubility, which limits its use and dosage in skin care products. Gallic acid and procyanidins contain excellent polyphenols, which have strong antioxidant activity and can neutralize free radicals and protect cells from oxidative stress damage, and have strong water solubility. In the above technical solution, gallic acid and procyanidins are used in combination with rutin in the above suitable ratio range; effectively realizing the application of rutin in cosmetics; and producing a synergistic effect, improving the antioxidant and whitening effects.

[0047] Further, it has been found through research that the antioxidant effect of the composition of the present application, especially the ABTS free radical scavenging rate, is significantly better than that of any single compound, not only saving costs but also indicating that gallic acid, procyanidins and rutin in the composition of the present application have a synergistic effect in antioxidant, and none of the three can be omitted. In addition, the inhibition effect of the composition on tyrosinase is also significantly better than that of other single use.

[0048] Further, the composition provided in the above technical solution of the present application is derived from plant secondary metabolites, which is green and natural, and is more suitable for skin care. In addition, the effects of the components are clear and can synergize to improve the antioxidant and whitening effects, which is more suitable for industrial production. When applied to cosmetics, the antioxidant and whitening effects of the cosmetics can be greatly enhanced, meeting the market demand for green and natural antioxidant products.

[0049] Further optionally, in some embodiments of the present application, when the antioxidant whitening composition comprises three of gallic acid, procyanidins and rutin, the mass ratio of gallic acid, procyanidins and rutin in the antioxidant whitening composition is (4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8 or a range between any two of the aforementioned values) : (1, 1.2, 1.3, 1.5, 2, 2.2, 2.5, 2.8, 3 or a range between any two of the aforementioned values) : (1, 1.2, 1.3, 1.5, 1.8, 2, 2.2, 2.5, 2.8, 3 or a range between any two of the aforementioned values) in mass ratio.

[0050] Further optionally, in some embodiments of the present application, when the antioxidant whitening composition comprises three of gallic acid, procyanidins and rutin, the mass ratio of gallic acid, procyanidins and rutin in the antioxidant whitening composition is (5-7) : (1.5-2.5) : (1.5-2.5) in mass ratio.

[0051] Further optionally, in some embodiments of the present application, when the antioxidant whitening composition comprises three of gallic acid, procyanidins and rutin, the mass ratio of gallic acid, procyanidins and rutin in the antioxidant whitening composition is 6:2:2 in mass ratio.

[0052] Further optionally, in some embodiments of the present application, when the antioxidant whitening composition comprises two of gallic acid, procyanidins and rutin, the mass ratio of any two of the raw materials is (1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3) : (1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3) in mass ratio.

[0053] Further optionally, in some embodiments of the present application, the antioxidant whitening composition comprises a gallic acid aqueous solution, a procyanidin aqueous solution and a rutin alkaline solution.

[0054] Further optionally, in some embodiments of the present application, the mass percentage of gallic acid in the gallic acid aqueous solution is 0.005%-0.05% in mass percentage.

[0055] Further optionally, in some embodiments of the present application, the mass percentage of gallic acid in the gallic acid aqueous solution is 0.01%-0.05% in mass percentage.

[0056] Illustratively, in some embodiments of the application, the mass percentage of gallic acid in the aqueous gallic acid solution described above is 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05% or a range between any two of the aforementioned values, in terms of mass percentage.

[0057] Further optionally, in some embodiments of the application, the mass percentage of procyanidins in the aqueous procyanidins solution is 0.005%-0.05%, in terms of mass percentage.

[0058] Illustratively, in some embodiments of the application, the mass percentage of procyanidins in the aqueous procyanidins solution described above is 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05% or a range between any two of the aforementioned values, in terms of mass percentage.

[0059] Further optionally, in some embodiments of the application, the mass percentage of procyanidins in the aqueous procyanidins solution is 0.01%-0.05%, in terms of mass percentage.

[0060] Further optionally, in some embodiments of the application, the aqueous rutin alkaline solution comprises rutin and aqueous sodium hydroxide.

[0061] The mass percentage of rutin in the aqueous rutin alkaline solution is 0.005%-0.05%, in terms of mass percentage.

[0062] Illustratively, in some embodiments of the application, the mass percentage of rutin in the aqueous rutin alkaline solution described above is 0.005%, 0.006%, 0.007%, 0.008%, 0.009%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05% or a range between any two of the aforementioned values, in terms of mass percentage.

[0063] Further optionally, in some embodiments of the application, the mass percentage of rutin in the aqueous rutin alkaline solution is 0.01%-0.05%, in terms of mass percentage.

[0064] Further optionally, in some embodiments of the present application, the mass percentage of sodium hydroxide in the aqueous sodium hydroxide solution is 0.1% to 1.5%.

[0065] Illustratively, in some embodiments of the present application, the mass percentage of sodium hydroxide in the aqueous sodium hydroxide solution is 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, or a range between any two of the aforementioned values.

[0066] Further optionally, in some embodiments of the present application, the mass percentage of sodium hydroxide in the aqueous sodium hydroxide solution is 0.5% to 1.0%.

[0067] Some embodiments of the present application provide a cosmetic product comprising the antioxidant whitening composition provided by any of the aforementioned embodiments.

[0068] Further optionally, in some embodiments of the present application, the antioxidant whitening composition is added in the cosmetic product in an amount of 5% or more.

[0069] Illustratively, in some embodiments of the present application, the antioxidant whitening composition is added in the cosmetic product in an amount of 5%, 6%, 7%, 8%, 9%, 10%, 12%, 15%, 18%, 20%, or a range between any two of the aforementioned values.

[0070] Further optionally, in some embodiments of the present application, the antioxidant whitening composition is added in the cosmetic product in an amount of 5% to 20%.

[0071] Further optionally, in some embodiments of the present application, the cosmetic product further comprises an aqueous phase, an oil phase, and optionally a preservative.

[0072] Further optionally, in some embodiments of the present application, the aqueous phase comprises glycerol, butylene glycol, and water.

[0073] Further optionally, in some embodiments of the present application, the oil phase comprises sodium hyaluronate and xanthan gum.

[0074] Further optionally, in some embodiments of the present application, the preservative comprises caprylyl oxyhydroxamic acid, ethylhexylglycerin, and 1,2-hexanediol.

[0075] Further optionally, in some embodiments of the application, the cosmetic includes, by mass percentage: glycerin 1-5%, butylene glycol 4-6%, sodium hyaluronate 0.01-1.00%, xanthan gum 0.01-0.20%, capryloyl hydroxamic acid 0.010-0.030%, ethylhexylglycerin 0.010-0.020%, 1,2-hexanediol 0.010-0.020%, antioxidant whitening composition 5-20%, and deionized water q.s. 100%.

[0076] Illustratively, in some embodiments of the application, the cosmetic includes, by mass percentage: glycerin 1%, 1.2%, 1.5%, 1.8%, 2%, 2.2%, 2.5%, 2.8%, 3%, 3.2%, 3.5%, 3.8%, 4%, 4.2%, 4.5%, 4.8%, 5%, or a range between any two of the foregoing;

[0077] butylene glycol 4%, 4.1%, 4.2%, 4.5%, 4.8%, 5.0%, 5.2%, 5.5%, 5.8%, 6%, or a range between any two of the foregoing;

[0078] sodium hyaluronate 0.01%, 0.02%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.5%, 0.8%, 1.00%, or a range between any two of the foregoing;

[0079] xanthan gum 0.01%, 0.02%, 0.05%, 0.08%, 0.1%, 0.12%, 0.15%, 0.18%, 0.20%, or a range between any two of the foregoing;

[0080] capryloyl hydroxamic acid 0.010%, 0.012%, 0.015%, 0.018%, 0.020%, 0.022%, 0.025%, 0.028%, 0.030%, or a range between any two of the foregoing;

[0081] ethylhexylglycerin 0.010%, 0.011%, 0.012%, 0.013%, 0.015%, 0.018%, 0.020%, or a range between any two of the foregoing;

[0082] 1,2-hexanediol 0.010%, 0.012%, 0.015%, 0.018%, 0.020%, or a range between any two of the foregoing;

[0083] antioxidant whitening composition 5%, 6%, 8%, 10%, 12%, 15%, 18%, 20%, or a range between any two of the foregoing; and deionized water q.s. 100%.

[0084] Further optionally, in some embodiments of the present application, the pH of the cosmetic is 6.5-7.5.

[0085] Illustratively, in some embodiments of the present application, the pH of the cosmetic is 6.5, 6.6, 6.7, 6.8, 6.9, 7.0, 7.1, 7.2, 7.3, 7.4, 7.5, or a range between any two of the foregoing.

[0086] Further optionally, in some embodiments of the present application, the pH of the cosmetic can be adjusted by adding a weak acid.

[0087] Illustratively, in some embodiments of the present application, citric acid or the like can be selected to adjust the pH.

[0088] Some embodiments of the present application provide a method for preparing a cosmetic lotion containing an antioxidant whitening composition, the method comprising:

[0089] mixing the oil phase raw materials to obtain an oil phase mixture;

[0090] mixing the water phase raw materials to obtain a water phase mixture;

[0091] mixing and emulsifying the oil phase mixture and the water phase mixture to obtain an emulsified mixture;

[0092] after the emulsified mixture is cooled to below 40°C, adding the antioxidant whitening composition to the emulsified mixture and mixing uniformly.

[0093] Optionally, in some embodiments of the present application, mixing the oil phase raw materials comprises dissolving and mixing the oil phase raw materials uniformly at 75-85°C.

[0094] Optionally, in some embodiments of the present application, mixing the water phase raw materials comprises heating and mixing the water phase raw materials uniformly at 75-85°C.

[0095] Optionally, in some embodiments of the present application, mixing and emulsifying the oil phase mixture and the water phase mixture comprises mixing the oil phase mixture and the water phase mixture and stirring at 400-600 rpm for 5-15 minutes to emulsify.

[0096] Illustratively, in some embodiments of the present application, the method for preparing a cosmetic lotion containing an antioxidant whitening composition is performed according to the following steps:

[0097] Step S1, dissolving butylene glycol in glycerol, heating to 75-85°C to dissolve, to obtain an oil phase mixture.

[0098] Exemplarily, in some embodiments of the present application, the butanediol is dissolved in glycerol, heated to 75℃, 76℃, 77℃, 78℃, 79℃, 80℃, 81℃, 82℃, 83℃, 84℃, 85℃, or a range between any two of the aforementioned values, to obtain an oil phase mixture.

[0099] Step S2, the sodium hyaluronate and xanthan gum are dissolved in water heated to 75℃-85℃ to obtain an aqueous phase mixture.

[0100] Exemplarily, in some embodiments of the present application, the sodium hyaluronate and xanthan gum are dissolved in water heated to 75℃, 76℃, 77℃, 78℃, 79℃, 80℃, 81℃, 82℃, 83℃, 84℃, 85℃, or a range between any two of the aforementioned values, to obtain an aqueous phase mixture.

[0101] Step S3, the aforementioned prepared aqueous phase mixture and oil phase mixture are sequentially pumped into an emulsifying pot, and stirred at 400-600 rpm for 5-15 minutes to obtain an emulsified mixture.

[0102] Exemplarily, in some embodiments of the present application, the aforementioned prepared aqueous phase mixture and oil phase mixture are sequentially pumped into an emulsifying pot, and stirred at 400 rpm, 410 rpm, 420 rpm, 430 rpm, 450 rpm, 480 rpm, 500 rpm, 500 rpm, 520 rpm, 550 rpm, 580 rpm, 600 rpm, or a range between any two of the aforementioned values; for 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 11 minutes, 12 minutes, 13 minutes, 14 minutes, 15 minutes, or a range between any two of the aforementioned values, to obtain an emulsified mixture.

[0103] Step S4, after the emulsified mixture obtained in the aforementioned step S3 is cooled to room temperature, caprylhydroxamic acid, ethylhexylglycerin, and 1,2-hexanediol are added, and stirred at 400-600 rpm for 5-15 minutes.

[0104] Exemplarily, in some embodiments of the present application, after the emulsified mixture obtained in the step S3 is cooled to room temperature, the antioxidant whitening composition provided in any of the preceding embodiments is added, and stirring is continued at 400 rpm, 410 rpm, 420 rpm, 430 rpm, 450 rpm, 480 rpm, 500 rpm, 500 rpm, 520 rpm, 550 rpm, 580 rpm, 600 rpm, or a range between any two of the aforementioned values; for 5 minutes, 6 minutes, 7 minutes, 8 minutes, 9 minutes, 10 minutes, 11 minutes, 12 minutes, 13 minutes, 14 minutes, 15 minutes, or a range between any two of the aforementioned values.

[0105] The step S5, after the emulsified mixture is cooled to room temperature, the antioxidant whitening composition provided in any of the preceding embodiments is added, and stirring is continued at 400 rpm to 600 rpm for 5 minutes to 15 minutes.

[0106] The step S5, after the emulsified mixture is cooled to room temperature, the antioxidant whitening composition provided in any of the preceding embodiments is added, and stirring is continued at 400 rpm to 600 rpm for 5 minutes to 15 minutes.

[0107] The step S6, an appropriate amount of citric acid is added and stirred uniformly to adjust the pH to 6.5-7.5, thereby obtaining a toner containing the antioxidant whitening composition.

[0108] The step S6, an appropriate amount of citric acid is added and stirred uniformly to adjust the pH to 6.5-7.5, thereby obtaining a toner containing the antioxidant whitening composition.

[0109] The features and performances of the present application are further described in detail below in combination with the following examples:

[0110] Examples 1-6

[0111] A cosmetic water is provided. An antioxidant whitening composition is prepared in a total amount of 100 mL. The final concentrations of each ingredient (gallic acid, procyanidine, rutin) in the composition are shown in Table 1. Then, 1000 mL of the cosmetic water is prepared according to the formulation and preparation process steps shown in Table 2 using the composition prepared in each example.

[0112] Example 7

[0113] A cosmetic water is provided. An antioxidant whitening composition is prepared in a total amount of 100 mL. The final concentrations of each ingredient (gallic acid, procyanidine, rutin) in the composition are shown in Table 1. Then, 1000 mL of the cosmetic water is prepared according to the formulation and preparation process steps shown in Table 2 using the composition prepared in each example.

[0114] Examples 8-12

[0115] A cosmetic water is provided. An antioxidant whitening composition is prepared in a total amount of 100 mL. The final concentrations of each ingredient (gallic acid, procyanidine, rutin) in the composition are shown in Table 1. Then, 1000 mL of the cosmetic water is prepared according to the formulation and preparation process steps shown in Table 2 using the composition prepared in each example.

[0116] Table 1. Antioxidant whitening composition (mass percentage)

[0117]

[0118]

[0119] Table 2. Composition of the cosmetic water

[0120] Ingredients Amount (mass percent) Glycerin 3％ Butylene glycol 5.4％ Sodium hyaluronate 0.05％ Xanthan gum 0.1％ Caprylyl oxyhydroxamic acid 0.025％ Ethylhexylglycerin 0.015％ 1,2-Hexanediol 0.015％ Antioxidant whitening composition 10％ Deionized water To 100%

[0121] The preparation process steps of the cosmetic water are as follows:

[0122] (1) Dissolve butanediol in glycerol and heat to 80°C to dissolve, which is the oil phase;

[0123] (2) Dissolve sodium hyaluronate and xanthan gum in water and heat to 80°C, which is the water phase;

[0124] (3) Draw the water phase and the oil phase into an emulsifying pot in sequence, and continuously stir at 500 rpm for 10 minutes;

[0125] (4) After the mixture is cooled to room temperature, add caprylhydroxamic acid, ethylhexylglycerin, and 1,2-hexanediol, and continuously stir at 500 rpm for 10 minutes;

[0126] (5) After the mixture is cooled to room temperature, the antioxidant whitening composition prepared in each example is added, and stirring is continued at 500 rpm for 10 minutes;

[0127] (6) Citric acid is added and stirred to homogeneity, and the pH is adjusted to 6.5-7.5 to obtain a cosmetic lotion containing the antioxidant whitening composition.

[0128] Comparative Example 1

[0129] Negative control, i.e., deionized water.

[0130] Comparative Example 2

[0131] Positive control, i.e., 200 μg / mL of a vitamin C aqueous solution in the ABTS radical scavenging test, 20 μg / mL of a vitamin C aqueous solution in the DPPH radical scavenging test, and 80 μg / mL of a kojic acid aqueous solution in the tyrosinase inhibition test.

[0132] Comparative Example 3

[0133] Blank control, i.e., a cosmetic lotion not containing the antioxidant whitening composition, which is prepared by mixing the following raw material components in the following proportions by weight:

[0134] Glycerin 3%, butylene glycol 5.4%, sodium hyaluronate 0.05%, xanthan gum 0.1%, caprylhydroxamic acid 0.025%, ethylhexylglycerin 0.015%, 1,2-hexanediol 0.015%, deionized water q.s. 100%, and citric acid q.s. to a pH of 6.5-7.5.

[0135] Comparative Example 4

[0136] Prepared as follows:

[0137] Gallic acid 0.0250 g is first dissolved in 100 mL of deionized water as the antioxidant whitening composition, and 1000 mL of a cosmetic lotion is then prepared according to the formulation of Table 2 above and the preparation procedure.

[0138] Comparative Example 5

[0139] Prepared as follows:

[0140] Proanthocyanidin 0.0250 g is first dissolved in 100 mL of deionized water as the antioxidant whitening composition, and 1000 mL of a cosmetic lotion is then prepared according to the formulation of Table 2 above and the preparation procedure.

[0141] Comparative Example 6

[0142] Prepared as follows:

[0143] First, rutin 0.0250 g was dissolved in 10 mL of 1% NaOH aqueous solution, diluted with water to 100 mL, and used as an antioxidant whitening composition. Then, 1000 mL of cosmetic water was prepared according to the formulation of Table 2 and the preparation procedure described above.

[0144] Comparative Example 7

[0145] First, gallic acid 0.0250 g and thymol 0.0250 g were dissolved in 100 mL of deionized water, and used as an antioxidant whitening composition. Then, 1000 mL of cosmetic water was prepared according to the formulation of Table 2 and the preparation procedure described above.

[0146] Comparative Example 8

[0147] First, procyanidin 0.0100 g was dissolved in 90 mL of deionized water, and rutin 0.0100 g and kinetin 0.0300 g were dissolved in 10 mL of 1% NaOH aqueous solution. The mixture was used as an antioxidant whitening composition. Then, 1000 mL of cosmetic water was prepared according to the formulation of Table 2 and the preparation procedure described above.

[0148] Comparative Example 9

[0149] First, gallic acid 0.0250 g and glucosamine 0.0250 g were dissolved in 100 mL of deionized water, and used as an antioxidant whitening composition. Then, 1000 mL of cosmetic water was prepared according to the formulation of Table 2 and the preparation procedure described above.

[0150] Comparative Example 10

[0151] First, gallic acid 0.0100 g, procyanidin 0.0100 g and thymol 0.0100 g were dissolved in 90 mL of deionized water, and rutin 0.0100 g and kinetin 0.0100 g were dissolved in 10 mL of 1% NaOH aqueous solution. The mixture was used as an antioxidant whitening composition. Then, 1000 mL of cosmetic water was prepared according to the formulation of Table 2 and the preparation procedure described above.

[0152] Comparative Example 11

[0153] First, grape seed extract (commercial raw material) 5 mL was dissolved in 100 mL of deionized water, and used as an antioxidant whitening composition. Then, 1000 mL of cosmetic water was prepared according to the formulation of Table 2 and the preparation procedure described above.

[0154] Comparative Example 12

[0155] First, tea extract (commercial raw material) 5 mL was dissolved in 100 mL of deionized water, and used as an antioxidant whitening composition. Then, 1000 mL of cosmetic water was prepared according to the formulation of Table 2 and the preparation procedure described above.

[0156]

Performance Test

[0157] 1. ABTS free radical scavenging test

[0158] Test method:

[0159] The ABTS free radical scavenging test was conducted in accordance with the standard T / GDCA 021-2023 "Evaluation of Antioxidant Activity of Cosmetics - Chemical Evaluation Method" to calculate the ABTS free radical scavenging rate of each example and comparative example.

[0160] Test results are available in the instruction manual. Figure 1 .

[0161] Depend on Figure 1 It can be seen that the ABTS free radical scavenging rate is ranked as follows: Example 4 > Example 7 > Example 1 > Comparative Examples 3-12. That is, when any one of gallic acid, proanthocyanidins and rutin is used alone, the highest ABTS free radical scavenging rate is 49.32%; while when the three raw materials are used in combination according to the proportions of this application, they can play an excellent synergistic effect, so that the ABTS free radical scavenging rate of the antioxidant whitening composition can reach 81.90% to 87.90% (Examples 7 and 4); all of which are significantly higher than Comparative Examples 3-12.

[0162] 2. DPPH free radical scavenging test

[0163] Test method:

[0164] Referring to the content of standard T / GDCA 021-2023 "Evaluation of antioxidant activity of cosmetics - Chemical evaluation method", the DPPH free radical scavenging rate of each example and comparative example was calculated.

[0165] Test results are available in the instruction manual. Figure 2 .

[0166] Depend on Figure 2 It can be seen that the DPPH free radical scavenging rate is ranked as follows: Example 4 > Example 1 > Example 7 > Comparative Examples 3-12. The DPPH free radical scavenging rates of the above three examples are similar to those of the positive control (Comparative Example 2), indicating that the antioxidant whitening composition has a very high DPPH free radical scavenging rate.

[0167] 3. Tyrosinase inhibition test

[0168] Test method:

[0169] Referring to the content of standard T / GDCA 006-2021 "Test Method for Inhibition of Tyrosinase Activity by Cosmetic Raw Materials (In Vitro Method)", the tyrosinase inhibition rate of each example and comparative example was calculated.

[0170] Test results are available in the instruction manual. Figure 3 .

[0171] It is found that the tyrosinase inhibition rates are ranked as follows: Example 10 > Example 7 > Example 5 > Comparative Example 3 - Comparative Example 12. Figure 3 Among them, the tyrosinase inhibition rates of Example 10 and Example 7 are significantly greater than those of Comparative Example 3 - Comparative Example 12, indicating that gallic acid, procyanidin and rutin have a certain synergistic effect after being compounded in the proportions of the present application, so that the tyrosinase inhibition rates are significantly improved.

[0172] In summary, the present application provides an antioxidant whitening composition derived from plant secondary metabolites, which has clear component efficacy and synergistic effect, and has important practical significance.

[0173] The above only describes the preferred embodiments of the present application and is not intended to limit the present application. For those skilled in the art, the present application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An antioxidant whitening composition, characterized in that, the antioxidant whitening composition is composed of three components: gallic acid, procyanidin and rutin; in terms of mass ratio, the mass ratio of the gallic acid, the procyanidin and the rutin in the antioxidant whitening composition is (5-7):(1.5-2.5):(1.5-2.5); or the antioxidant whitening composition is composed of two components: gallic acid and procyanidin; in terms of mass ratio, the mass ratio of the gallic acid and the procyanidin in the antioxidant whitening composition is (1-3):(1-3); or the antioxidant whitening composition is composed of two components: procyanidin and rutin; in terms of mass ratio, the mass ratio of the gallic acid and the procyanidin in the antioxidant whitening composition is (1-3):(1-3).

2. The antioxidant whitening composition according to claim 1, characterized in that, in terms of mass ratio, the mass ratio of the gallic acid, the procyanidin and the rutin in the antioxidant whitening composition is 6:2:

2.

3. The antioxidant whitening composition according to any one of claims 1-2, characterized in that, the antioxidant whitening composition is composed of a gallic acid aqueous solution, a procyanidin aqueous solution and a rutin alkaline solution.

4. The antioxidant whitening composition according to claim 3, characterized in that, in terms of mass percentage, the mass percentage of the gallic acid in the gallic acid aqueous solution is 0.005%-0.05%.

5. The antioxidant whitening composition according to claim 4, characterized in that, in terms of mass percentage, the mass percentage of the procyanidin in the procyanidin aqueous solution is 0.005%-0.05%.

6. The antioxidant whitening composition according to claim 3, characterized in that, the rutin alkaline solution is composed of rutin and a sodium hydroxide aqueous solution; in terms of mass percentage, the mass percentage of the rutin in the rutin alkaline solution is 0.005%-0.05%; in terms of mass percentage, the mass percentage of the sodium hydroxide in the sodium hydroxide aqueous solution is 0.1%-1.5%.

7. A cosmetic product, characterized by The cosmetic product comprises the antioxidant whitening composition according to any one of claims 1-6.

8. The cosmetic product according to claim 7, characterized in that, in terms of mass percentage, the addition amount of the antioxidant whitening composition in the cosmetic product is 5% or more.

9. The cosmetic product according to claim 8, characterized in that, the cosmetic product further comprises an aqueous phase, an oil phase and a preservative.

10. The cosmetic product according to claim 9, characterized in that, The aqueous phase comprises glycerol, butylene glycol and water.

11. The cosmetic product according to claim 9, characterized in that, The oil phase comprises sodium hyaluronate and xanthan gum.

12. The cosmetic product of claim 9, wherein, The preservative comprises caprylhydroxamic acid, ethylhexylglycerin and 1,2-hexanediol.

13. The cosmetic product according to claim 9, characterized in that, The cosmetic comprises, in percentage by mass: glycerin 1%~5%, butylene glycol 4%~6%, sodium hyaluronate 0.01%~1.00%, xanthan gum 0.01%~0.20%, caprylhydroxamic acid 0.010%~0.030%, ethylhexylglycerin 0.010%~0.020%, 1,2-hexanediol 0.010%~0.020%, antioxidant whitening composition 5%~20%, and deionized water, the rest.

14. The cosmetic product of claim 9, wherein, The pH of the cosmetic is 6.5-7.

5.

15. The method of preparing a cosmetic according to any one of claims 7 to 14, characterized in that, The method comprises: mixing oil phase raw materials to obtain an oil phase mixture; mixing water phase raw materials to obtain a water phase mixture; mixing and emulsifying the oil phase mixture and the water phase mixture to obtain an emulsified mixture; after the emulsified mixture is cooled to below 40℃, adding the antioxidant whitening composition into the emulsified mixture and mixing uniformly.

16. The method according to claim 15, wherein the mixing of the oil phase raw materials comprises dissolving and mixing the oil phase raw materials uniformly at 75℃~85℃.

17. The method according to claim 15, wherein the mixing of the water phase raw materials comprises heating and mixing the water phase raw materials uniformly at 75℃~85℃.

18. The method according to claim 15, wherein the mixing and emulsifying of the oil phase mixture and the water phase mixture comprises mixing the oil phase mixture and the water phase mixture and stirring at 400~600 rpm for 5~15 minutes for emulsification.

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