Gel composition residing in stomach and used for locking wine and dispelling effects of alcohol as well as preparation method and application of gel composition

Abstract

The invention relates to the technical field of hangover alleviating substances, in particular to an intra-stomach resident gel composition for locking wine and alleviating hangover as well as a preparation method and application of the intra-stomach resident gel composition. The raw materials of the gel composition residing in the stomach are selected from carboxymethyl fiber raw materials, alginic acid raw materials, probiotics capable of converting alcohol or fermentation products of the probiotics and a calcium source; the mass relationship of the components in the raw materials meets the following conditions: W1 = m < 2 > / (m1 + m < 2 >) * 100%, and 13% < = W1 < = 25%; w2 = m < 3 > / (m1 + m < 2 > + m < 3 >) * 100%, and W2 > = 5%; f = m4 / m5, 0.2 < = f < = 1.5. The gel composition not only can adsorb a large amount of alcohol in the stomach and reduce the amount of alcohol entering blood, but also can convert alcohol into acetic acid, and finally acetic acid is metabolized into carbon dioxide and water through a human body.

Description

Technical Field

[0001] The invention relates to the technical field of alcohol sobering substances, and in particular to a gastric resident gel composition for locking and sobering up alcohol, a preparation method and application thereof. Background Art

[0002] Studies have shown that about 90% of the alcohol consumed by the human body is metabolized in the liver. Most of the alcohol is first converted into acetaldehyde by alcohol dehydrogenase, and then acetaldehyde is converted into acetic acid by acetaldehyde dehydrogenase, and finally decomposed into carbon dioxide and water and excreted from the body. However, acetaldehyde is a toxic substance that has a direct toxic effect on liver cells. Long-term drinking will overload the liver, causing repeated fatty degeneration of liver cells, which in turn causes diseases such as alcoholic fatty liver, cirrhosis and liver cancer, becoming an important risk factor for serious health problems.

[0003] Existing technologies often use food, herbs and enzymes to alleviate the adverse reactions after alcohol withdrawal, but these methods cannot reduce alcohol absorption in the gastrointestinal tract. The biotransformation strategy uses microorganisms in the gastrointestinal tract to directly or exogenously transform alcohol with enzymes, such as alcohol dehydrogenase / acetaldehyde dehydrogenase mixtures, acetic bacteria, etc., which can effectively alleviate abdominal pain, headaches, nausea and other problems after drinking.

[0004] Among them, Acetobacter, Bacillus coagulans, recombinant Lactococcus lactis and Bacillus subtilis are a type of probiotics that can oxidize sugars and alcohol into products such as acetic acid, and are the basis of the vinegar industry. For example, studies have shown that the fermented mixture of Acetobacter pasteurianus contains alcohol dehydrogenase and acetaldehyde dehydrogenase, which has a good effect on relieving hangovers. However, its low pH in the gastric acid environment has problems with reduced activity and stability, and it cannot effectively relieve the adverse reactions after alcohol withdrawal.

[0005] In view of this, the present invention is proposed. Summary of the invention

[0006] The object of the present invention is to provide a gastric resident gel composition for locking and sobering up alcohol, a preparation method thereof and its application. The embodiment of the present invention provides a new gastric resident gel composition that can not only absorb a large amount of alcohol in the stomach and reduce the amount of alcohol entering the blood, but also convert alcohol into acetic acid, which is eventually metabolized into carbon dioxide and water by the human body. It can achieve the retention of bacteria or metabolites in the upper digestive tract, and effectively reduce alcohol absorption without completely relying on alcohol abstinence, protect the metabolic activity of bacteria or metabolites in the gastrointestinal environment, and then delay and reduce the speed and time of alcohol entering the blood, reducing the damage caused by alcohol to the nervous system and liver.

[0007] The present invention is achieved in that:

[0008] In a first aspect, the present invention provides a gastric resident gel composition for locking and sobering up alcohol, wherein the raw materials are selected from carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products, and a calcium source; and the mass relationship of each component in the raw materials satisfies:

[0009] W1=m2 / (m1+m2)×100%, and 13%≤W1≤25%;

[0010] W2=m3 / (m1+m2+m3)×100%, and W2≥5%;

[0011] f=m4 / m5,0.2≤f≤1.5;

[0012] Wherein, m1 is the mass of the carboxymethyl cellulose raw material, m2 is the mass of the alginate raw material, and m3 is the mass of the probiotics capable of converting alcohol or its fermentation product;

[0013] m4 is the Ca in the calcium source 2+ m5 is the mass of carboxyl groups in the alginate raw material.

[0014] In an optional embodiment, the adsorption rate of the intragastric resident gel composition for 43% alcohol is ≥1000%;

[0015] Preferably, W2 ≥ 10%;

[0016] Preferably, the elastic modulus of the gel formed by the intragastric retention gel composition is greater than 1000 Pa.

[0017] In an optional embodiment, when the concentration of the carboxymethyl cellulose raw material in the solution is 2%, the viscosity is ≥3000 mPa·S.

[0018] In an optional embodiment, the carboxymethyl cellulose raw material includes carboxymethyl cellulose or a salt thereof;

[0019] Preferably, the salt of carboxymethyl cellulose includes any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose and ammonium carboxymethyl cellulose.

[0020] In an optional embodiment, when the concentration of the alginate raw material in the solution is 2%, the viscosity is ≥3000 mPa·S.

[0021] In an optional embodiment, the alginic acid raw material includes alginic acid or a salt thereof;

[0022] Preferably, the alginate raw material includes any one of sodium alginate, potassium alginate and ammonium alginate.

[0023] In an optional embodiment, the calcium source is a calcium source with low solubility;

[0024] Preferably, the calcium source includes at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate or calcium phosphate;

[0025] More preferably, the calcium source is calcium carbonate.

[0026] In an optional embodiment, the probiotic bacteria capable of converting alcohol is selected from at least one of Acetobacter, Bacillus coagulans, recombinant Lactococcus lactis and Bacillus subtilis.

[0027] In a second aspect, the present invention provides a method for preparing the gastric resident gel composition for locking and sobering up alcohol as described in the aforementioned embodiment, comprising: mixing carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products, and a calcium source;

[0028] Preferably, the method comprises: mixing carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products and water, and then drying at 30-40° C. to obtain material A, and crushing and screening;

[0029] (2) then mixing the material A with a calcium source to obtain a product;

[0030] Preferably, the concentration of the carboxymethyl cellulose raw material and the alginic acid raw material in the water is 3-15%;

[0031] Preferably, the particle size of the material A is 0.1 mm to 2 mm, more preferably 0.3 mm to 2 mm, and more preferably 0.3 mm to 1 mm.

[0032] In a third aspect, the present invention provides a use of the gastric resident gel composition for locking and sobering up alcohol as described in the aforementioned embodiment in the preparation of a sobering up product;

[0033] Preferably, the hangover sobering product comprises a hangover sobering medicine or a hangover sobering health product.

[0034] The present invention has the following beneficial effects: the gastric resident gel composition for locking and sobering up alcohol provided by the embodiment of the present invention absorbs a large amount of alcohol in the stomach to form a gel. Due to the certain strength of the gel, it can resist the grinding force generated by gastric peristalsis, thereby delaying gastric emptying, slowing down the speed of alcohol reaching the intestine, and then reducing the time for alcohol to enter the blood. At the same time, the probiotics capable of converting alcohol in the gastric resident gel composition or its fermentation product can convert alcohol into acetic acid, and the acetic acid is finally metabolized into carbon dioxide and water by the human body, further reducing the damage of alcohol to the human body. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for use in the embodiments are briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without creative work.

[0036] Figure 1 The test result diagram provided for Experimental Example 1 of the present invention;

[0037] Figure 2 This is a test result diagram provided for Experimental Example 2 of the present invention. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0039] In a first aspect, the present invention provides a gastric resident gel composition for locking and sobering up alcohol, wherein the raw materials are selected from carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products, and a calcium source; and the mass relationship of each component in the raw materials satisfies:

[0040] W1=m2 / (m1+m2)×100%, and 10%≤W1≤25%;

[0041] W2=m3 / (m1+m2+m3)×100%, and W2≥5%; preferably, W2≥10%;

[0042] f=m4 / m5,0.2≤f≤1.5;

[0043] Wherein, m1 is the mass of the carboxymethyl cellulose raw material, m2 is the mass of the alginate raw material, m3 is the mass of the probiotics capable of converting alcohol or its fermentation product; m4 is the Ca content in the calcium source. 2+ m5 is the mass of carboxyl groups in the alginate raw material.

[0044] The gastric resident gel composition provided by the embodiment of the present invention can quickly absorb alcohol and provide good protection for the bacteria or fermentation products inside, and then use the bacteria or fermentation products inside to convert ethanol into acetic acid. It can achieve the retention of bacteria or metabolites in the upper digestive tract, and effectively reduce alcohol absorption without completely relying on alcohol abstinence, protect the metabolic activity of bacteria or metabolites in the gastrointestinal environment, and then delay and reduce the speed and time of alcohol entering the blood, reducing the damage caused by alcohol to the nervous system and liver.

[0045] Specifically, the gastric resident gel composition has an adsorption rate of ≥1000% for 43% alcohol. Therefore, it can be used to prepare alcohol sobering products, such as alcohol sobering medicines or alcohol sobering health products.

[0046] When the concentration of carboxymethyl cellulose raw materials in the solution is 2%, the viscosity is ≥3000 mPa·S. Carboxymethyl cellulose raw materials include carboxymethyl cellulose or its salts, for example, the salt of carboxymethyl cellulose includes but is not limited to any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose and ammonium carboxymethyl cellulose.

[0047] When the concentration of the alginic acid raw material in the solution is 2%, the viscosity is ≥3000 mPa·S. The alginic acid raw material includes alginic acid or its salt, for example, the alginic acid raw material includes but is not limited to any one of sodium alginate, potassium alginate and ammonium alginate.

[0048] It should be noted that the above viscosity refers to the properties of the alginate-based raw material or the carboxymethyl cellulose-based raw material itself.

[0049] The calcium source is a low-solubility calcium source; for example, the calcium source includes but is not limited to at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate or calcium phosphate; more preferably, the calcium source is calcium carbonate.

[0050] When calcium carbonate is preferably used as the calcium source in the embodiment of the present invention, as gastric acid is secreted, calcium ions are generated by reaction, which are cross-linked with sodium alginate to form a three-dimensional network, thereby increasing its ability to adsorb alcohol. However, the amount of HCl secreted by gastric acid is limited and insufficient to completely react with calcium carbonate. Therefore, as the acetic acid converted from the internal alcohol after alcohol adsorption reacts with calcium carbonate, the sodium alginate is further cross-linked, forming a cycle of alcohol adsorption-alcohol conversion-cross-linking-alcohol adsorption, thereby forming a synergistic effect.

[0051] The probiotics capable of converting alcohol are selected from at least one of acetic acid bacteria, bacillus coagulans, recombinant lactococcus lactis and bacillus subtilis.

[0052] The elastic modulus of the gel formed by the intragastric resident gel composition is greater than 1000 Pa.

[0053] In a second aspect, the present invention provides a method for preparing the gastric resident gel composition for locking and sobering up alcohol as described in the aforementioned embodiment, comprising: mixing carboxymethyl cellulose raw materials, alginate raw materials, probiotics capable of converting alcohol or their fermentation products, and a calcium source.

[0054] Specifically, carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products and water are mixed, and then dried at 30-40° C. to obtain material A, which is then crushed and sieved. The material A is then mixed with a calcium source to obtain the material. At this time, the particle size of the material A is 0.1 mm to 2 mm, more preferably 0.3 mm to 2 mm, and more preferably 0.3 mm to 1 mm.

[0055] Alternatively, the carboxymethyl cellulose raw material, the alginic acid raw material, the probiotics capable of converting alcohol or its fermentation product, the calcium source and water can be directly mixed.

[0056] The concentration of the carboxymethyl cellulose raw material and the alginic acid raw material in the water is 3-15%, and the concentration refers to the mass content of the carboxymethyl cellulose raw material and the alginic acid raw material in the water.

[0057] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0058] Example 1

[0059] The embodiment of the present invention provides a method for preparing a gastric resident gel composition for locking and sobering up alcohol, comprising:

[0060] 3.0g sodium alginate (2% aqueous solution viscosity is 4000mPa·s), 20g sodium carboxymethyl cellulose (2% aqueous solution viscosity is 6000mPa·s), 10.6g acetobacter fermentation product (W1=13.0%, W2=31.5%), 500mL deionized water are placed in a dough mixer and mixed evenly to form a uniform suspension. The suspension is transferred to a metal tray, and the thickness of the suspension in the metal tray is controlled to be less than 1cm, and then the metal tray is placed at 70°C and dried for 24h to obtain solid A material. The solid A material is placed in a pulverizer and crushed, passed through 16 mesh and 150 mesh sieves, and sieved to obtain granular A material with a particle size of 0.1-1mm, which is packaged for standby use.

[0061] Calcium lactate is mixed with granular material A, wherein the mass of calcium lactate and the mass of sodium alginate in material A satisfy f=0.2.

[0062] Example 2

[0063] The embodiment of the present invention provides a method for preparing a gastric resident gel composition for locking and sobering up alcohol, comprising:

[0064] 5.0g sodium alginate (2% aqueous solution viscosity is 8000mPa·s), 20g sodium carboxymethyl cellulose (2% aqueous solution viscosity is 4000mPa·s), 3.8g calcium carbonate, 10.6g acetic acid bacteria fermentation product (W1=20.0%, W2=29.8%), 500mL deionized water are placed in a dough mixer and mixed evenly to form a uniform suspension. The suspension is transferred to a metal tray, and the thickness of the suspension in the metal tray is controlled to be less than 1cm. The metal tray is then placed at 35±2°C and dried for 72h to obtain a gel composition dry material. The gel composition dry material is placed in a grinder and crushed, passed through 16 mesh and 150 mesh sieves, and sieved to obtain a granular material A with a particle size of 0.1-1mm, which is packaged for standby use. f=1.2.

[0065] Example 3

[0066] The embodiment of the present invention provides a method for preparing a gastric resident gel composition for locking and sobering up alcohol, comprising:

[0067] 5.0g sodium alginate (2% aqueous solution viscosity is 6000mPa·s), 20g sodium carboxymethyl cellulose (2% aqueous solution viscosity is 7000mPa·s), 1.2g calcium carbonate, 10.6g acetic acid bacteria fermentation product (W1=20.0%, W2=29.8%), 500mL water are placed in a dough mixer and mixed evenly to form a uniform suspension. The suspension is transferred to a metal tray, and the thickness of the suspension in the metal tray is controlled to be below 1cm, and then the metal tray is placed at 35±2℃ and dried for 72h to obtain a gel composition dry material. The gel composition dry material is placed in a grinder and crushed, passed through 10 mesh and 120 mesh screens, and sieved to obtain a granular A material with a particle size of 0.1-1.7mm, which is packaged for standby use, f=0.38.

[0068] Example 4

[0069] The embodiment of the present invention provides a method for preparing a gastric resident gel composition for locking and sobering up alcohol, comprising:

[0070] 8.3g sodium alginate (2% aqueous solution viscosity is 12000mPa·s), 24.9g sodium carboxymethyl cellulose (2% aqueous solution viscosity is 4500mPa·s), 15.0g acetic acid bacteria powder (W1=20.0%, W2=40%), 500mL water are placed in a dough mixer and mixed evenly to form a uniform suspension. The suspension is transferred to a metal tray, and the thickness of the suspension in the metal tray is controlled to be below 1cm, and then the metal tray is placed at 35±2℃ and dried for 24h to obtain solid A material. The solid A material is placed in a pulverizer and crushed, passed through 18 mesh and 50 mesh screens, and sieved to obtain granular A material with a particle size of 0.27-0.88mm, which is packaged for standby use.

[0071] Calcium lactate is mixed with granular material A, wherein the mass of calcium lactate and the mass of sodium alginate in material A satisfy f=0.5.

[0072] Example 5

[0073] The embodiment of the present invention provides a method for preparing a gastric resident gel composition for locking and sobering up alcohol. The preparation method refers to the preparation method of Example 2, except that the fermentation product of Acetobacter is replaced by the fermentation product of Bacillus subtilis, and other operating conditions, raw material selection and dosage are the same as those in Example 2.

[0074] Comparative Example 1

[0075] This comparative example provides a preparation method of a gel composition. The preparation method refers to the preparation method of Example 2, except that no acetobacillus fermentation product is used, and other operating conditions, raw material selection and dosage are the same as those of Example 2.

[0076] Comparative Example 2

[0077] This comparative example provides a method for preparing a gel composition. The preparation method refers to the preparation method of Example 2, with the only difference being that f is 0.1, and other operating conditions, raw material selection, and dosage are the same as those of Example 2.

[0078] Comparative Example 3

[0079] This comparative example provides a method for preparing a gel composition. The preparation method is referred to the preparation method of Example 2, with the only difference being that W1 is 35%, and other operating conditions, raw material selection and dosage are the same as those of Example 2.

[0080] Comparative Example 4

[0081] K-Nut* brand acetobacter fermentation powder is available in the market.

[0082] Experimental Example 1

[0083] According to Appendix H of GB / T 22875-2018, the physiological saline was replaced with 43% liquor, and the absorption of liquor by the gel compositions of Examples 1-5 and Comparative Examples 1-4 was measured respectively. The absorption amount X*100 was obtained to obtain the adsorption rate (%) of alcohol. The elastic modulus G' of the filtered hydrogel was measured by a rheometer (the value corresponding to the angular frequency of 10 rad / s was uniformly taken), and the results are shown in Table 1.

[0084] Table 1 Comparison results of absorption test

[0085]

[0086]

[0087] According to Table 1, by adjusting the mass ratio of carboxymethyl cellulose raw materials, alginate raw materials and calcium source, the gel compositions described in Examples 1-5 were successfully prepared, and the adsorption rates of 43% (v / v) liquor were all greater than 2000%, and the elastic moduli were all greater than 2000Pa, which is more conducive to resisting the grinding force generated by gastric peristalsis, so that it can stay in the stomach for a longer time without being destroyed; although Comparative Example 2 has a very high adsorption rate, the strength is only 550, which is not conducive to staying in the stomach for a longer time; at the same time, the adsorption rate of Comparative Example 3 is relatively low, and Comparative Example 4 is a fermentation product that does not have the ability to adsorb alcohol.

[0088] Experimental Example 2

[0089] Bama Xiang pigs were selected to study different doses of the gastric resident gel composition prepared in Example 2, and the gastric emptying rate of different doses at 4 hours was studied. Specifically, 20 1*10 mm long barium strips were dispersed in the gel particles (350 g of feed + 20 barium strips + X g of gel composition particles + 1 L of water + 120 mL of 52% liquor, x = 0.75, 1.5, 2.25, 3.0), gastric emptying rate = (20-remaining barium strips in the stomach) / 20, and the results are shown in Figure 1 .

[0090] according to Figure 1 It can be seen that the gel prepared in Example 2 can prolong the gastric emptying time. Although different doses show certain differences, the gastric emptying rate is lower than that of the gel composition prepared without adding Example 2. This is because the calcium source and sodium alginate are cross-linked to form a three-dimensional network structure, which enhances the strength of the gel, so that it can resist the grinding force generated by gastric peristalsis and stay in the stomach.

[0091] Experimental Example 3

[0092] 30 volunteers were recruited to test the real effect of the intragastric resident gel composition, which was taken once a day for 3 consecutive days. The volunteers were randomly assigned to Example 2, Comparative Example 1 and Comparative Example 4 in a ratio of 1:1. The volunteers took 2.4g of granules (previously encapsulated in capsules) 30 minutes before drinking. Compared with the previous state, the volunteers evaluated the anti-alcohol effect after taking the medicine, and scored in three aspects: relieving hangover, increasing alcohol tolerance, and accelerating soberness. 10 points are the full score, 5 points or less are considered useless, and 8 points or more are considered satisfactory. Then the satisfaction ratios were calculated separately. The results are shown in Figure 2 .

[0093] according to Figure 2It can be seen that the satisfaction of Comparative Examples 1 and 4 in the three evaluation dimensions of relieving hangover, increasing alcohol tolerance, and accelerating sobering up is not as high as that of the gel composition prepared in Example 1. This is because the gel has a three-dimensional network structure, which can adsorb alcohol to reduce the free concentration and slow down its entry into the blood, but it is only physically stored temporarily. For a single fermentation product, alcohol can be converted into harmless substances, but its activity is limited by the complex gastrointestinal environment, such as low pH and content. Then for the gel composition of Example 1, the gel adsorbs alcohol to create a stable environment for the fermentation product, and the fermentation product efficiently converts adsorption and free alcohol, thereby improving the conversion efficiency of alcohol sobering up; second, the gel shields unfavorable factors, protects enzyme activity and prevents its degradation and inactivation; third, the gel slowly releases alcohol, prolongs the metabolic time, avoids a sudden increase in alcohol concentration and aggravates drunkenness, and provides a sufficient action window for the fermentation product. The overall alcohol sobering effect is better than that of using it alone, achieving the effect of 1+1>2.

[0094] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A gastric resident gel composition for locking and sobering up alcohol, characterized in that: The raw materials are selected from carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products and calcium sources; and the mass relationship of each component in the raw materials satisfies: W1=m2 / (m1+m2)×100%, and 13%≤W1≤25%; W2=m3 / (m1+m2+m3)×100%, and W2≥5%; f=m4 / m5,0.2≤f≤1.5; Wherein, m1 is the mass of the carboxymethyl cellulose raw material, m2 is the mass of the alginate raw material, and m3 is the probiotics or their fermentation products; m4 is the Ca in the calcium source 2+ m5 is the mass of carboxyl groups in the alginate raw material.

2. The gastric resident gel composition for locking and sobering up alcohol according to claim 1, characterized in that: The adsorption rate of the gastric resident gel composition for 43% alcohol is ≥1000%; Preferably, W2 ≥ 10%; Preferably, the elastic modulus of the gel formed by the intragastric retention gel composition is greater than 1000 Pa.

3. The gastric resident gel composition for locking and sobering up alcohol according to claim 1, characterized in that: When the concentration of the carboxymethyl cellulose raw material in the solution is 2%, the viscosity is ≥3000 mPa·S.

4. The gastric resident gel composition for locking and sobering up alcohol according to claim 1, characterized in that: The carboxymethyl cellulose raw material includes carboxymethyl cellulose or its salt, Preferably, the carboxymethyl cellulose raw material includes any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose and ammonium carboxymethyl cellulose.

5. The gastric resident gel composition for locking and sobering up alcohol according to claim 1, characterized in that: When the concentration of the alginate raw material in the solution is 2%, the viscosity is ≥3000 mPa·S.

6. The gastric resident gel composition for locking and sobering up alcohol according to claim 1, characterized in that: The alginic acid raw material includes alginic acid or its salt, Preferably, the alginate raw material includes any one of sodium alginate, potassium alginate and ammonium alginate.

7. The gastric resident gel composition for locking and sobering up alcohol according to claim 1, characterized in that: The calcium source is a calcium source with low solubility; Preferably, the calcium source includes at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate or calcium phosphate; More preferably, the calcium source is calcium carbonate.

8. The gastric resident gel composition for locking and sobering up alcohol according to any one of claims 1 to 7, characterized in that: The probiotics capable of converting alcohol are selected from at least one of acetic acid bacteria, bacillus coagulans, recombinant lactococcus lactis and bacillus subtilis.

9. A method for preparing the gastric resident gel composition for locking and sobering up alcohol according to claim 1, characterized in that: include: Mixing carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products and a calcium source; Preferably, the method comprises: (1) mixing carboxymethyl cellulose raw materials, alginic acid raw materials, probiotics capable of converting alcohol or their fermentation products and water, and then drying at 30-40° C. to obtain material A, and crushing and screening, (2) then mixing the material A with a calcium source; Preferably, the concentration of the carboxymethyl cellulose raw material and the alginic acid raw material in the water is 3-15%; Preferably, the particle size of the material A is 0.1 mm to 2 mm, more preferably 0.3 mm to 2 mm, and more preferably 0.3 mm to 1 mm.

10. Use of the gastric resident gel composition for locking and sobering up alcohol according to claim 1 in the preparation of a sobering up product; Preferably, the hangover sobering product comprises a hangover sobering medicine or a hangover sobering health product.

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