Composition for reconstruction of private flora and preparation method thereof

Abstract

The invention discloses a composition for reconstruction of private flora and a preparation method of the composition. The preparation method comprises the following steps: S1, putting plant gel, a traditional Chinese medicine extracting solution and a repairing agent into a stirring device, and uniformly mixing the plant gel, the traditional Chinese medicine extracting solution and the repairing agent; s2, carrying out sterilization treatment on the mixed raw materials by adopting ionizing radiation; and S3, adding the mixed bacterial agent into the sterilized raw materials, and then stirring through the stirring device to form the composition. The plant gel, the traditional Chinese medicine extracting solution, the repairing agent, the mixed microbial agent and the like are filled into the porous capsule, and the porous capsule is subjected to hole sealing through the hole sealing agent, so that the hole sealing agent on the porous capsule can be melted after the porous capsule is put into a private part, and effective components in the porous capsule slowly flow out; the internal part of the private part can fully absorb the effective components, so that a large amount of effective components are prevented from flowing out when people stand, and the effect of flora in the private part during reconstruction is better.

Description

Technical Field

[0001] The present invention relates to the technical field of private part care, and in particular to a composition for private part flora reconstruction and a preparation method thereof. Background Art

[0002] As people's pace of life becomes faster, their mental stress is also increasing, and various physical problems will also occur, such as dysbacteriosis in the female private part, which is a state caused by the destruction of the balance of vaginal flora. There are many kinds of bacteria in the vagina, which maintain a delicate balance with the vaginal environment. Dysbacteriosis in the private part can lead to inflammation and various gynecological diseases in the private part. Therefore, reconstruction of the private part flora after dysbacteriosis is crucial to maintain vaginal health.

[0003] Chinese patent application No. 202110 012892.7 relates to a composition for repairing the microecological balance of female private parts, and its preparation method and application. The raw materials for preparing the composition for repairing the microecological balance of female private parts include: gallnut, cnidium monnieri, moutan bark, sophora flavescens and Lactobacillus plantarum fermentation products. The composition involved in the present invention is composed of traditional Chinese medicine and lactobacillus fermentation products. Each Chinese medicine component has a certain antibacterial ability against Staphylococcus aureus, Escherichia coli and Candida albicans in female private parts from different aspects. The added Lactobacillus plantarum fermentation product can effectively increase the abundance of Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus and other flora in the normal microbial community of the private parts, and at the same time can adjust the pH value of the vagina, form an acidic barrier, and further inhibit the growth of pathogenic bacteria.

[0004] At present, when rebuilding the flora of the private part, gel-like drugs are usually directly administered into the private part, but patients need to stand during daily activities, which will cause a large amount of drugs to flow out from the private part, thereby affecting the absorption of active ingredients and the efficiency of rebuilding the flora of the private part. Therefore, it is urgent to design a composition for rebuilding the flora of the private part and a preparation method thereof to solve the above problems. Summary of the invention

[0005] The purpose of the present invention is to provide a composition for private part flora reconstruction and a preparation method thereof, so as to solve the above-mentioned deficiencies in the prior art.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A composition for rebuilding private part flora comprises the following raw materials in parts by weight: 2-50 parts of plant gel, 1-10 parts of traditional Chinese medicine extract, 5-10 parts of repair agent, 2-15 parts of mixed bacterial agent and 1-50 parts of sealing agent.

[0008] A method for preparing a composition for rebuilding private part flora, characterized in that it comprises the following steps:

[0009] S1: Put the plant gel, Chinese medicine extract and repair agent into a stirring device and mix them evenly;

[0010] S2: sterilizing the mixed raw materials by ionizing radiation;

[0011] S3: adding the mixed bacterial agent to the sterilized raw material, and then stirring again by a stirring device to form a composition;

[0012] S4: filling the composition into a porous capsule at low temperature, and connecting a sterile cotton thread to the capsule;

[0013] S5: Immerse the porous capsule in the melted sealing agent, then take out the porous capsule and quickly put it into a low-temperature environment for cooling and sealing, and then use a vacuum packaging machine to package it and store it at low temperature.

[0014] Furthermore, in S1, the method for preparing the Chinese medicine extract comprises the following steps:

[0015] S1.1: Wash dandelions and honeysuckle with deionized water, and chop them into small pieces after washing;

[0016] S1.2: Soaking the chopped dandelion and honeysuckle in water, and then reflux extraction and filtering;

[0017] S1.3: The filtrate is pumped into a concentrator to be concentrated under reduced pressure, and the concentrate is allowed to stand and then centrifuged to obtain the Chinese medicine extract.

[0018] Furthermore, in said S2, the radiation dose during sterilization is 5-20 kGy.

[0019] Furthermore, in S3, the stirring device is first rotated at a speed of 400-600 rpm for 10-30 minutes, and then rotated at a speed of 600-800 rpm for 10-30 minutes.

[0020] Furthermore, in S4, the porous capsule is made of silica gel, and the pore size of the porous capsule is 1-3 mm.

[0021] Furthermore, in S5, the sealing agent is composed of one or more substances selected from the group consisting of gelatin, glycerol and polyethylene glycol 400.

[0022] Furthermore, in S3, the mixed bacterial agent is composed of one or more of Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium bifidum, Bacillus subtilis, Bacillus licheniformis and Bacillus cereus.

[0023] Furthermore, in S1, the repair agent is Kangfuxin liquid.

[0024] In the above technical scheme, the present invention provides a composition for reconstructing private flora and a preparation method thereof, and the beneficial effects are as follows: the present invention loads plant gel, Chinese medicine extract, repair agent and mixed bacterial agent into the interior of a porous capsule, and seals the porous capsule with a sealing agent, so that after the porous capsule is placed inside the private part, the sealing agent on the porous capsule will melt, thereby allowing the effective ingredients inside the porous capsule to slowly flow out, so that the private part can fully absorb the effective ingredients, preventing a large amount of effective ingredients from flowing out when a person stands, thereby making the flora inside the private part better during reconstruction; the harmful bacteria inside the private part are inhibited by the Chinese medicine extract, and then the repair agent repairs the damaged mucosa inside the private part, and at the same time, the probiotics are directly introduced into the private part by the mixed bacterial agent, so that the efficiency of private flora reconstruction is higher. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present invention. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0026] Figure 1 The present invention is a flow chart of a method for preparing a composition for rebuilding private part flora. DETAILED DESCRIPTION

[0027] In order to enable those skilled in the art to better understand the technical solution of the present invention, Figure 1 The present invention is further described in detail.

[0028] Example 1

[0029] A composition for rebuilding private part flora comprises the following raw materials in parts by weight: 50 parts of plant gel, 10 parts of traditional Chinese medicine extract, 5 parts of repair agent, 3 parts of mixed bacterial agent and 30 parts of sealing agent.

[0030] A method for preparing a composition for rebuilding private part flora, characterized in that it comprises the following steps:

[0031] S1: Put the plant gel, Chinese medicine extract and repair agent into a stirring device and mix them evenly to prevent the local aggregation of various substances. The repair agent is Kangfuxin liquid, which has good wound repair function and can repair the damaged mucous membrane of the private parts;

[0032] S2: sterilize the mixed raw materials with ionizing radiation at a radiation dose of 20 kGy. Ionizing radiation sterilization does not require heating and will not destroy the active ingredients of the substance.

[0033] S3: adding the mixed bacterial agent to the sterilized raw material, and then stirring again by a stirring device to form a composition, the stirring device is first rotated at a speed of 500 rpm for 10 minutes, and then at a speed of 800 rpm for 10 minutes to make the mixing more uniform, the mixed bacterial agent is composed of Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium bifidum, Bacillus subtilis, Bacillus licheniformis and Bacillus cereus; Lactobacillus acidophilus, Lactobacillus rhamnosus and Lactobacillus casei belong to the lactobacillus class, this type of probiotics can Sugar and carbohydrates are converted into lactic acid to maintain the pH of the vagina and reduce the growth of harmful bacteria. Bifidobacterium longum, Bifidobacterium breve and Bifidobacterium bifidum belong to the bifidobacterium class. This type of probiotic can synthesize amino acid substances, which are absorbed and used by the intestines, thereby improving the body's immunity and helping to prevent vaginitis, cervicitis and other gynecological diseases. Probiotic Bacillus subtilis, Bacillus licheniformis, Bacillus cereus and other probiotic Bacillus can inhibit the growth and reproduction of harmful bacteria, and can also produce enzyme substances such as protease and amylase, enhancing the immunity of multiple systems such as the gastrointestinal system and the reproductive system.

[0034] S4: Fill the composition into a porous capsule at low temperature, and connect a sterile cotton thread to the capsule. The porous capsule is made of silicone material, and the pore size of the porous capsule is 2 mm. When in use, the sterile cotton thread needs to be exposed to the outside of the private part. When the active ingredient flows out of the porous capsule, the porous capsule can be pulled out by the sterile cotton thread to prevent the porous capsule from remaining inside the private part.

[0035] S5: Immerse the porous capsule in the melted sealing agent, then take out the porous capsule and quickly put it into a low-temperature environment for cooling and sealing, and then use a vacuum packaging machine to package it and store it at low temperature. The sealing agent is composed of three substances: gelatin, glycerin and polyethylene glycol 400.

[0036] Furthermore, in S1, the method for preparing the Chinese medicine extract comprises the following steps:

[0037] S1.1: Wash dandelion and honeysuckle with deionized water, and then chop them. Dandelion and honeysuckle have broad-spectrum antibacterial activity. The active ingredients in dandelion and honeysuckle can significantly inhibit Staphylococcus aureus, Staphylococcus epidermidis, hemolytic Streptococcus, and Catarrhalis, and will not irritate the private mucosa or interfere with probiotics. The ratio of dandelion to honeysuckle is 1:1.

[0038] S1.2: Soaking the chopped dandelion and honeysuckle in water, and then reflux extraction and filtering;

[0039] S1.3: The filtrate is pumped into a concentrator to be concentrated under reduced pressure. The concentrate is allowed to stand and then centrifuged to obtain a Chinese medicine extract.

[0040] Example 2

[0041] A composition for rebuilding private part flora comprises the following raw materials in parts by weight: 50 parts of plant gel, 10 parts of traditional Chinese medicine extract, 7 parts of repair agent, 3 parts of mixed bacterial agent and 30 parts of sealing agent.

[0042] A method for preparing a composition for rebuilding private part flora, characterized in that it comprises the following steps:

[0043] S1: Put the plant gel, Chinese medicine extract and repair agent into a stirring device and mix them evenly to prevent the local aggregation of various substances. The repair agent is Kangfuxin liquid, which has good wound repair function and can repair the damaged mucous membrane of the private parts;

[0044] S2: sterilize the mixed raw materials with ionizing radiation at a radiation dose of 20 kGy. Ionizing radiation sterilization does not require heating and will not destroy the active ingredients of the substance.

[0045] S3: adding the mixed bacterial agent to the sterilized raw material, and then stirring again by a stirring device to form a composition, the stirring device is first rotated at a speed of 500 rpm for 10 minutes, and then at a speed of 800 rpm for 10 minutes to make the mixing more uniform, the mixed bacterial agent is composed of Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium bifidum, Bacillus subtilis, Bacillus licheniformis and Bacillus cereus; Lactobacillus acidophilus, Lactobacillus rhamnosus and Lactobacillus casei belong to the lactobacillus class, this type of probiotics can Sugar and carbohydrates are converted into lactic acid to maintain the pH of the vagina and reduce the growth of harmful bacteria. Bifidobacterium longum, Bifidobacterium breve and Bifidobacterium bifidum belong to the bifidobacterium class. This type of probiotic can synthesize amino acid substances, which are absorbed and used by the intestines, thereby improving the body's immunity and helping to prevent vaginitis, cervicitis and other gynecological diseases. Probiotic Bacillus subtilis, Bacillus licheniformis, Bacillus cereus and other probiotic Bacillus can inhibit the growth and reproduction of harmful bacteria, and can also produce enzyme substances such as protease and amylase, enhancing the immunity of multiple systems such as the gastrointestinal system and the reproductive system.

[0046] S4: Fill the composition into a porous capsule at low temperature, and connect a sterile cotton thread to the capsule. The porous capsule is made of silicone material, and the pore size of the porous capsule is 2 mm. When in use, the sterile cotton thread needs to be exposed to the outside of the private part. When the active ingredient flows out of the porous capsule, the porous capsule can be pulled out by the sterile cotton thread to prevent the porous capsule from remaining inside the private part.

[0047] S5: Immerse the porous capsule in the melted sealing agent, then take out the porous capsule and quickly put it into a low-temperature environment for cooling and sealing, and then use a vacuum packaging machine to package it and store it at low temperature. The sealing agent is composed of three substances: gelatin, glycerin and polyethylene glycol 400.

[0048] Furthermore, in S1, the method for preparing the Chinese medicine extract comprises the following steps:

[0049] S1.1: Wash dandelion and honeysuckle with deionized water, and then chop them. Dandelion and honeysuckle have broad-spectrum antibacterial activity. The active ingredients in dandelion and honeysuckle can significantly inhibit Staphylococcus aureus, Staphylococcus epidermidis, hemolytic Streptococcus, and Catarrhalis, and will not irritate the private mucosa or interfere with probiotics. The ratio of dandelion to honeysuckle is 1:1.

[0050] S1.2: Soaking the chopped dandelion and honeysuckle in water, and then reflux extraction and filtering;

[0051] S1.3: The filtrate is pumped into a concentrator to be concentrated under reduced pressure. The concentrate is allowed to stand and then centrifuged to obtain a Chinese medicine extract.

[0052] Example 3

[0053] A composition for rebuilding private part flora comprises the following raw materials in parts by weight: 50 parts of plant gel, 10 parts of traditional Chinese medicine extract, 9 parts of repair agent, 3 parts of mixed bacterial agent and 30 parts of sealing agent.

[0054] A method for preparing a composition for rebuilding private part flora, characterized in that it comprises the following steps:

[0055] S1: Put the plant gel, Chinese medicine extract and repair agent into a stirring device and mix them evenly to prevent the local aggregation of various substances. The repair agent is Kangfuxin liquid, which has good wound repair function and can repair the damaged mucous membrane of the private parts;

[0056] S2: sterilize the mixed raw materials with ionizing radiation at a radiation dose of 20 kGy. Ionizing radiation sterilization does not require heating and will not destroy the active ingredients of the substance.

[0057] S3: adding the mixed bacterial agent to the sterilized raw material, and then stirring again by a stirring device to form a composition, the stirring device is first rotated at a speed of 500 rpm for 10 minutes, and then at a speed of 800 rpm for 10 minutes to make the mixing more uniform, the mixed bacterial agent is composed of Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium bifidum, Bacillus subtilis, Bacillus licheniformis and Bacillus cereus; Lactobacillus acidophilus, Lactobacillus rhamnosus and Lactobacillus casei belong to the lactobacillus class, this type of probiotics can Sugar and carbohydrates are converted into lactic acid to maintain the pH of the vagina and reduce the growth of harmful bacteria. Bifidobacterium longum, Bifidobacterium breve and Bifidobacterium bifidum belong to the bifidobacterium class. This type of probiotic can synthesize amino acid substances, which are absorbed and used by the intestines, thereby improving the body's immunity and helping to prevent vaginitis, cervicitis and other gynecological diseases. Probiotic Bacillus subtilis, Bacillus licheniformis, Bacillus cereus and other probiotic Bacillus can inhibit the growth and reproduction of harmful bacteria, and can also produce enzyme substances such as protease and amylase, enhancing the immunity of multiple systems such as the gastrointestinal system and the reproductive system.

[0058] S4: Fill the composition into a porous capsule at low temperature, and connect a sterile cotton thread to the capsule. The porous capsule is made of silicone material, and the pore size of the porous capsule is 2 mm. When in use, the sterile cotton thread needs to be exposed to the outside of the private part. When the active ingredient flows out of the porous capsule, the porous capsule can be pulled out by the sterile cotton thread to prevent the porous capsule from remaining inside the private part.

[0059] S5: Immerse the porous capsule in the melted sealing agent, then take out the porous capsule and quickly put it into a low-temperature environment for cooling and sealing, and then use a vacuum packaging machine to package it and store it at low temperature. The sealing agent is composed of three substances: gelatin, glycerin and polyethylene glycol 400.

[0060] Furthermore, in S1, the method for preparing the Chinese medicine extract comprises the following steps:

[0061] S1.1: Wash dandelion and honeysuckle with deionized water, and then chop them. Dandelion and honeysuckle have broad-spectrum antibacterial activity. The active ingredients in dandelion and honeysuckle can significantly inhibit Staphylococcus aureus, Staphylococcus epidermidis, hemolytic Streptococcus, and Catarrhalis, and will not irritate the private mucosa or interfere with probiotics. The ratio of dandelion to honeysuckle is 1:1.

[0062] S1.2: Soaking the chopped dandelion and honeysuckle in water, and then reflux extraction and filtering;

[0063] S1.3: The filtrate is pumped into a concentrator to be concentrated under reduced pressure. The concentrate is allowed to stand and then centrifuged to obtain a Chinese medicine extract.

[0064] The number of repair agents used in Example 1, Example 2 and Example 3 was different, and the other parameters were the same. 80 patients with dysbiosis of private parts were divided into four groups for testing. After the experiment, samples were taken from the private parts of all the subjects to detect the reconstruction of the flora. The detailed experimental results are shown in the following table:

[0065]

[0066] From the comparison of the number of people who are satisfied with the effect of private part flora reconstruction in the above table, it can be seen that the composition finally obtained by Example 3 has the best effect.

[0067] The above description is only by way of illustration of certain exemplary embodiments of the present invention. It is undoubted that those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A composition for rebuilding private part flora, characterized in that: The invention comprises the following raw materials in parts by weight: 2-50 parts of plant gel, 1-10 parts of traditional Chinese medicine extract, 5-10 parts of repair agent, 2-15 parts of mixed bacterial agent and 1-50 parts of sealing agent.

2. The method for preparing a composition for rebuilding private part flora according to claim 1, characterized in that: The following steps are involved: S1: Put the plant gel, Chinese medicine extract and repair agent into a stirring device and mix them evenly; S2: sterilizing the mixed raw materials by ionizing radiation; S3: adding the mixed bacterial agent to the sterilized raw material, and then stirring again by a stirring device to form a composition; S4: filling the composition into a porous capsule at low temperature, and connecting a sterile cotton thread to the capsule; S5: Immerse the porous capsule in the melted sealing agent, then take out the porous capsule and quickly put it into a low-temperature environment for cooling and sealing, and then use a vacuum packaging machine to package it and store it at low temperature.

3. The method for preparing a composition for rebuilding private part flora according to claim 2, characterized in that: In S1, the method for preparing the Chinese medicine extract comprises the following steps: S1.1: Wash dandelions and honeysuckle with deionized water, and chop them into small pieces after washing; S1.2: Soaking the chopped dandelion and honeysuckle in water, and then reflux extraction and filtering; S1.3: The filtrate is pumped into a concentrator to be concentrated under reduced pressure, and the concentrate is allowed to stand and then centrifuged to obtain the Chinese medicine extract.

4. The method for preparing a composition for rebuilding private part flora according to claim 2, characterized in that: In said S2, the radiation dose during sterilization is 5-20 kGy.

5. The method for preparing a composition for rebuilding private part flora according to claim 2, characterized in that: In S3, the stirring device first rotates at a speed of 400-600 rpm for 10-30 minutes, and then rotates at a speed of 600-800 rpm for 10-30 minutes.

6. The method for preparing a composition for rebuilding private part flora according to claim 2, characterized in that: In the S4, the porous capsule is made of silica gel, and the pore size of the porous capsule is 1-3 mm.

7. The method for preparing a composition for rebuilding private part flora according to claim 2, characterized in that: In S5, the sealing agent is composed of one or more substances selected from the group consisting of gelatin, glycerol and polyethylene glycol 400.

8. The method for preparing a composition for rebuilding private part flora according to claim 2, characterized in that: In S3, the mixed bacterial agent is composed of one or more of Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium bifidum, Bacillus subtilis, Bacillus licheniformis and Bacillus cereus.

9. The method for preparing a composition for rebuilding private part flora according to claim 2, characterized in that: In S1, the repair agent is Kangfuxin liquid.

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