A traditional Chinese medicine composition for treating ischemic stroke and its preparation method and application

By treating Chuanxiong with composite bacteria and enzymatic hydrolysis, the laccase method was used to enhance the extraction and efficacy of the active ingredients of the traditional Chinese medicine composition, forming a traditional Chinese medicine composition for treating deficiency, enhancing the extraction and efficacy of the active ingredients of the traditional Chinese medicine composition, enhancing the blood circulation and analgesic effects of the traditional Chinese medicine composition, reducing neurological dysfunction caused by cerebral ischemia, and protecting neurological damage caused by ischemic stroke.

CN119700881BActive Publication Date: 2025-09-19GUANGDONG XINBAO PHARMA TECH CO LTD
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Patent Information

Application Number
CN202411938688.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-12-26
Publication Date
2025-09-19
Estimated Expiration
2044-12-26

AI Technical Summary

Technical Problem

Existing methods for extracting the active ingredients of Chuanxiong are not ideal, which affects its efficacy in treating ischemic stroke and lacks effective neuroprotective effects.

Method used

The method of composite bacterial fermentation and composite enzyme treatment is adopted to treat Chuanxiong, using Aconitum carlesioides, Lactobacillus plantarum and Bacillus subtilis to produce laccase, combined with cellulase and phospholipase to enhance the extraction of active ingredients and medicinal efficacy of Chuanxiong, thus forming a traditional Chinese medicine composition.

Benefits of technology

It significantly enhances the blood-activating and analgesic effects of the traditional Chinese medicine combination, alleviates neurological dysfunction caused by cerebral ischemia, and protects neurological damage caused by ischemic stroke.

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Abstract

The present invention relates to a Chinese medicine composition for treating ischemic stroke, and a method and application thereof, and belongs to the technical field of traditional Chinese medicine. The Chinese medicine composition for treating ischemic stroke disclosed in the present invention comprises the following raw materials: ginseng, Panax notoginseng, processed Polygonum multiflorum, Chuanxiong, safflower, salvia miltiorrhiza, hawthorn, mistletoe, epimedium, kudzu root, buffalo horn, ginseng leaf, calamus, and borneol. In the present invention, Chuanxiong is fermented with a composite bacteria consisting of Lactobacillus plantarum, Bacillus subtilis, and Acoriformis scabra, so that more laccase and active substances are produced in the fermentation product. The fermentation product is then treated with the composite enzyme, and the Chuanxiong obtained by the treatment has better medicinal efficacy, thereby enhancing the therapeutic effect of the Chinese medicine composition for treating ischemic stroke, significantly alleviating neurological dysfunction caused by cerebral ischemia, and having a good protective effect on neurological damage caused by ischemic stroke.
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