Seasonal affective disorder composition as well as preparation method and application thereof

Abstract

The invention particularly relates to a seasonal affective disorder composition as well as a preparation method and application thereof. The seasonal affective disorder composition is prepared from 3, 7-dimethyl octanol, myrtenol, caryophyllene, L-carvone, an angelica sinensis and radix bupleuri extract and a rhizoma cyperi and mint extract. The seasonal affective disorder composition can be applied to preparation of aromatherapy tablets. The aromatherapy sheet is prepared from the following raw materials in percentage by mass: 1 to 20 percent of seasonal affective disorder composition, 50 to 90 percent of carrier filling agent, 0.05 to 10 percent of emulsifying agent and 0.01 to 1 percent of thickening agent. All the raw materials in the composition cooperate with one another, the synergistic interaction effect is achieved, a stress biomarker alpha-amylase can be inhibited, the seasonal affective disorder symptom can be relieved, and the preparation method of the composition is simple in process and high in production efficiency. When the aromatherapy piece is used, positive emotion can be brought to a user, and pleasure can be improved.

Description

Technical Field

[0001] The invention relates to the technical field of food additives, and in particular to a seasonal affective disorder composition, an emulsion flavor, and a preparation method and an antibacterial testing method thereof. Background Art

[0002] Seasonal affective disorder (SAD) refers to depression or bipolar disorder with obvious seasonality, and the onset and relief of emotional symptoms often occur at fixed times of the year. SAD most often begins in the colder months (autumn and winter) and spontaneously improves in the spring or summer of the second year, with excessive sleep, increased appetite and low mood as the main symptoms.

[0003] Since it was defined in 1984, its pathogenesis and treatment have always attracted the attention of psychiatrists. Since SAD has great similarities in symptoms with other mental disorders and comorbidity with other mental disorders (ethanol abuse), it increases the difficulty of diagnosis, so it is often misdiagnosed and neglected in clinical practice. According to statistics, the prevalence of SAD is as high as 10%, of which 70% are diagnosed with recurrent major depressive disorder. In European countries and the United States, the prevalence of SAD assessed using the Seasonal Pattern Assessment Questionnaire (SPAQ) is between 4.3% and 10.0%, while the prevalence of SAD assessed using a diagnostic interview is between 0.4% and 2.4%. At present, there are not many related studies in China, and most foreign studies focus on light therapy.

[0004] Aromatherapy is a convenient and comfortable holistic therapy with various forms that can meet the deep needs of people's body and mind. When people inhale the aroma, the chemical molecules of these fragrances will awaken the memories stored in the memory center, stimulate the limbic system, activate the amygdala, and produce specific emotions, which is the effect of the emotional brain. Smells are so closely related to emotions that specific smells can affect emotions, help relieve negative emotions, and soothe nerves, thereby bringing positive emotions to users. Therefore, it is of great significance to provide a seasonal affective disorder composition and its application in multiple fields such as medicine, skin care, daily home, and car aromatherapy to bring positive emotions to users. Summary of the invention

[0005] In order to overcome the shortcomings and deficiencies in the prior art, the object of the present invention is to provide a seasonal affective disorder composition and a preparation method thereof; the composition can suppress and relieve the symptoms of seasonal affective disorder and bring a positive and optimistic state to the user, and the preparation method thereof has a simple process, high production efficiency, and is conducive to industrial production.

[0006] Another object of the present invention is to provide an aromatherapy tablet containing a seasonal affective disorder composition and a preparation method thereof, wherein the aromatherapy tablet, when used, helps to bring positive emotions to the user and enhance pleasure.

[0007] The purpose of the present invention is achieved by the following technical scheme: a seasonal affective disorder composition, comprising 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica radix and bupleurum extract, and cyperus rotundus and mint extract. The raw materials in the composition cooperate with each other, have a synergistic effect, can inhibit the stress biomarker alpha-amylase, and help alleviate the symptoms of seasonal affective disorder.

[0008] Furthermore, the seasonal affective disorder composition comprises the following raw materials in percentage by mass: 0.2-5% of 3,7-dimethyloctanol, 0.5-4% of myrtle alcohol, 1-10% of caryophyllene, 0.1-1% of L-carvone, 2-30% of angelica and bupleurum extract, 2-50% of cyperus rotundus and mint extract, and the remainder being solvent.

[0009] In the present invention, the 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica and bupleurum extract, and cyperus rotundus and mint extract cooperate with each other to have a synergistic effect, soothe the liver and relieve depression, nourish the blood and harmonize the liver, and at the same time put the user into the lively and fresh and bright situation of spring, generating a positive, relaxed and happy mood. Among them, 3,7-dimethyloctanol has a sweet rose aroma and is also one of the main components of Bupleurum volatile oil, which makes people feel like they are in a sea of ​​flowers, with the liver relaxed and the sun shining; myrtle alcohol has a fresh grassy fragrance and soft sandalwood fragrance, and also has the effect of removing phlegm and inhibiting mucus secretion, making breathing more refreshing and smooth, just like being on an open grassland, relaxing and relieving stress; caryophyllene has a root-like woody fragrance and a faint citrus fragrance. It is one of the volatile oil components of Bupleurum and American ginseng, making people feel like they are in the mountains, full of vitality; L-carvone has a cool feeling of spearmint, and at the same time has a green herbal fragrance, fresh and sweet, and eliminates boredom; Angelica sinensis replenishes blood and harmonizes blood, Bupleurum soothes the liver and relieves depression, and the combination of the two makes the liver blood full and comfortable; Cyperus rotundus promotes qi and relieves depression, and mint soothes the liver and relieves heat, and the combination of soothing the depressed qi and the above substances helps to improve the above symptoms.

[0010] Further, the solvent is at least one of ethanol, glycerol and propylene glycol. Further, the solvent is ethanol.

[0011] Furthermore, the preparation method of the angelica and bupleurum extract comprises the following steps: respectively crushing angelica and bupleurum into particles, adding ethanol, heating and refluxing for 2 times, and concentrating under reduced pressure to an extract with a relative density of 1.15-1.35, thereby obtaining the angelica and bupleurum extract. The mass ratio of angelica to bupleurum is 1-4:1-4.

[0012] Furthermore, in the preparation method of the Angelica and Bupleurum extract, the concentration of ethanol is 70-80%, the amount of ethanol added is 3-10 times the total mass of Angelica and Bupleurum, and each heating reflux is 2-3 hours.

[0013] Furthermore, the preparation method of the cyperus rotundus and mint extract comprises the following steps: crushing cyperus rotundus and mint into particles respectively, adding water, connecting a volatile oil extractor, extracting volatile oil by steam distillation, collecting volatile oil, filtering, collecting filtrate, boiling the filter residue once again, filtering; combining the two filtrates, adding ethanol precipitation, filtering to remove solid impurities, concentrating the filtrate to a relative density of 1.08-1.28, then adding polysorbate and polyoxyethylene hydrogenated castor oil, and stirring evenly. The mass ratio of cyperus rotundus and mint is 1-4:1-4.

[0014] Furthermore, in the preparation method of the Cyperus rotundus and mint extract, the amount of water added is 10-20 times the total mass of Cyperus rotundus and mint; the amount of polysorbate added is 15-25% of the mass of the volatile oil; and the amount of polyoxyethylene hydrogenated castor oil added is 25-65% of the mass of the volatile oil.

[0015] Taking into account that the incidence of SAD is lowest in spring, the present invention adopts a method of combining odor and fragrance with traditional Chinese medicine theory, combining aromatic substances with the scent of spring, such as floral fragrance, young leaf and green grass fragrance, forest wood fragrance, and moist cool feeling with plant extracts that soothe the liver, relieve depression and regulate blood, to provide a seasonal affective disorder composition and its application in multiple fields such as medicine, skin care, daily home use, and car aromatherapy.

[0016] In the present invention, a method for preparing the seasonal affective disorder composition comprises the following steps: (1) Weigh 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica sinensis bupleurum extract and cyperus rotundus mint extract according to proportion; (2) Add 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica and bupleurum extract and cyperus rotundus extract into a container, then add a solvent, and mix well until a clear liquid is obtained, thereby obtaining a seasonal affective disorder composition.

[0017] The present invention also provides application of the seasonal affective disorder composition, and the seasonal affective disorder composition can be applied to prepare aromatherapy tablets.

[0018] In the present invention, an aromatherapy tablet containing a seasonal affective disorder composition comprises the following raw materials in percentage by mass: 1-20% of the seasonal affective disorder composition, 50-90% of a carrier filler, 0.05-10% of an emulsifier, and 0.01-1% of a thickener.

[0019] Furthermore, the carrier filler is beeswax; the emulsifier is at least one of glyceride emulsifiers, polysorbate emulsifiers and silicone oil emulsifiers; and the thickener is at least one of carrageenan, carrageenan, sodium alginate, xanthan gum, pectin, agar and gelatin.

[0020] The present invention also provides a method for preparing the aromatherapy tablet containing the seasonal affective disorder composition, comprising the following steps: (S1) Melting the carrier filler: heating beeswax at 48-55°C until it melts, adding an oil-soluble emulsifier and stirring until it is completely blended; the oil-soluble emulsifier (S2) Pretreatment of the seasonal affective disorder composition: weigh the seasonal affective disorder composition, add a thickener and an emulsifier, and stir evenly; the emulsifier is a water-soluble emulsifier. (S3) Adding the seasonal affective disorder composition: adding the treated seasonal affective disorder composition to the melted beeswax, continuing heating and stirring, until the composition is fully integrated into the beeswax and has a uniform color, taking it out while hot and pouring it into a mold, letting it stand to cool, and demolding it after solidification to obtain an aromatherapy tablet containing the seasonal affective disorder composition.

[0021] When the aromatherapy tablets of the present invention are used, they help to bring positive emotions to the user and enhance the sense of pleasure. The preparation method thereof has simple process, convenient control, high production efficiency, and is conducive to industrial production.

[0022] Furthermore, the amount of the oil-soluble emulsifier added is 1-10% of the beeswax.

[0023] Furthermore, in step (2), the amount of the emulsifier added is 0.05-10% of the total mass of the aromatherapy tablet, and the amount of the thickener added is 0.01-1% of the total mass of the aromatherapy tablet.

[0024] The beneficial effects of the present invention are as follows: the seasonal affective disorder composition of the present invention cooperates 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica bupleurum extract, and cyperus rotundus mint extract, which has a synergistic effect, can further inhibit the stress biomarker alpha-amylase, help alleviate the symptoms of seasonal affective disorder, and bring a positive and optimistic state to the user. The preparation method is simple in process, high in production efficiency, and conducive to industrial production. The seasonal affective disorder composition can be used to prepare aromatherapy tablets, which, when used, help bring positive emotions to the user and enhance pleasure. The preparation method is simple in process, convenient to control, and high in production efficiency. DETAILED DESCRIPTION

[0025] In order to facilitate the understanding of those skilled in the art, the present invention is further described below in conjunction with embodiments, and the contents mentioned in the implementation modes are not intended to limit the present invention.

[0026] Example 1 In this embodiment, a method for preparing a seasonal affective disorder composition comprises the following steps: weighing 0.2 g of 3,7-dimethyloctanol, 0.5 g of myrtenol, 1 g of caryophyllene, 0.1 g of L-carvone, 30 g of angelica and bupleurum extract, and 50 g of cyperus and mint extract into a beaker, adding ethanol to 100 g, stirring at 40° C. for 30 min until the liquid is clear, and obtaining a seasonal affective disorder composition.

[0027] Furthermore, the preparation method of the Angelica and Bupleurum extract includes the following steps: respectively crushing Angelica and Bupleurum into coarse particles, adding an appropriate amount of ethanol, heating and reflux twice, combining the alcohol extracts, and concentrating under reduced pressure to an extract with a relative density of 1.2 to obtain the Angelica and Bupleurum extract; the ethanol concentration is 75%, the amount of ethanol added is 6 times the total mass of Angelica and Bupleurum, and each heating and reflux is 2.5 hours; the mass ratio of Angelica and Bupleurum is 1:1.

[0028] Furthermore, the preparation method of the cyperus rotundus and mint extract comprises the following steps: crushing cyperus rotundus and mint into particles respectively, adding water, connecting a volatile oil extractor, extracting volatile oil by steam distillation, collecting volatile oil, filtering, collecting filtrate, boiling the filter residue once again, and filtering; combining the two filtrates, adding ethanol to precipitate, filtering to remove solid impurities, concentrating the filtrate to a relative density of 1.15, and then adding polysorbate and polyoxyethylene hydrogenated castor oil, and stirring evenly; the mass ratio of cyperus rotundus and mint is 1:1; Furthermore, in the preparation method of the Cyperus rotundus and mint extract, the amount of water added is 15 times the total mass of Cyperus rotundus and mint; the amount of polysorbate added is 20% of the mass of the volatile oil; and the amount of polyoxyethylene hydrogenated castor oil added is 40% of the mass of the volatile oil.

[0029] This embodiment also provides an aromatherapy tablet containing a seasonal affective disorder composition, comprising the following raw materials in percentage by mass: 10% of the seasonal affective disorder composition, 84% of a carrier filler, 5.5% of an emulsifier, and 0.5% of a thickener. The carrier filler is beeswax, and the beeswax is added with an oil-soluble emulsifier.

[0030] The preparation method of the aromatherapy tablet containing the seasonal affective disorder composition comprises the following steps: (S1) Melting the carrier filler: heating beeswax at 50°C until it melts, adding a small amount of oil-soluble emulsifier and stirring until it is completely blended; the oil-soluble emulsifier is glyceryl monostearate, and the amount of the oil-soluble emulsifier added is 5% of the mass of the beeswax; (S2) Pretreatment of the seasonal affective disorder composition: weigh the seasonal affective disorder composition, add a thickener and a water-soluble emulsifier, and stir evenly; the thickener is carrageenan, and the water-soluble emulsifier is polysorbate 80; (S3) Adding the seasonal affective disorder composition: adding the treated seasonal affective disorder composition to the melted beeswax, continuing heating and stirring, until the composition is fully integrated into the beeswax and has a uniform color, taking it out and pouring it into a mold while it is hot, letting it stand and cool, and demolding it after it solidifies to obtain an aromatherapy tablet containing the seasonal affective disorder composition.

[0031] Example 2 In this embodiment, a method for preparing a seasonal affective disorder composition comprises the following steps: weighing 5 g of 3,7-dimethyloctanol, 4 g of myrtenol, 10 g of caryophyllene, 1 g of L-carvone, 2 g of angelica and bupleurum extract, and 2 g of cyperus and mint extract into a beaker, adding ethanol to 100 g, stirring at 40° C. for 30 min until the liquid is clear, and obtaining a seasonal affective disorder composition.

[0032] The rest of the content of this embodiment is the same as that of Embodiment 1.

[0033] Example 3 In this embodiment, a method for preparing a seasonal affective disorder composition comprises the following steps: weighing 1 g of 3,7-dimethyloctanol, 2 g of myrtenol, 5 g of caryophyllene, 0.5 g of L-carvone, 10 g of angelica and bupleurum extract, and 20 g of cyperus and mint extract into a beaker, adding ethanol to 100 g, stirring at 40° C. for 30 min until the liquid is clear, and obtaining a seasonal affective disorder composition.

[0034] The rest of the content of this embodiment is the same as that of Embodiment 1.

[0035] Comparative Example 1 The difference between this comparative example and Example 1 is that in the preparation method of the seasonal affective disorder composition, 3,7-dimethyloctanol is replaced by an equal mass of rose oxide. Comparative Example 2 The difference between this comparative example and Example 1 is that in the preparation method of the seasonal affective disorder composition, myrtenol is replaced by thymol of the same mass. Comparative Example 3 The difference between this comparative example and Example 1 is that in the preparation method of the seasonal affective disorder composition, caryophyllene is replaced with isoeugenol of equal mass. Comparative Example 4 The difference between this comparative example and Example 1 is that in the preparation method of the seasonal affective disorder composition, L-carvone is replaced by an equal mass of linalool oxide.

[0036] Test Example 1 Salivary alpha-amylase (sAA) level test Test samples: compositions of Examples 1-3 and compositions of Comparative Examples 1-4; Subjects: The subjects were 200 females aged between 20 and 36 years old, randomly divided into 20 groups, 10 in each group, healthy, without olfactory disorders or allergies; Test method: The subjects were prohibited from eating, smoking, or exercising vigorously 2 hours before the experiment. During the experiment, scented paper stained with the composition of Examples 1-3 and Comparative Examples 1-4 was placed in the subject's room, and no scented paper was placed in the blank group. The subjects were asked to take a math test of appropriate difficulty in the room. Saliva samples were collected from the subjects before and after the test. After the saliva samples were processed, the changes in the α-amylase level in the saliva were determined using a kinetic reaction assay kit (Salimetrics, State College, PA). The specific test results are shown in Table 1 below: Table 1

[0037] As shown in Table 1 above, the changes in the α-amylase level in the saliva of the subjects before and after the stress test show that when the fragrance is not used, that is, the blank test data, the α-amylase level in the saliva increases by 39.6% after the test, and when the subjects are in the environment of the composition of different formulas, it can be seen that the α-amylase level in the saliva after the test is reduced to varying degrees compared with the blank group. The embodiment fragrance composition provided by the present invention has the most obvious reduction effect, which fully demonstrates that the 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica bupleurum extract, and cyperus rotundus mint extract cooperate with each other, have a synergistic effect, and can further inhibit the stress biomarker α-amylase.

[0038] Test Example 2 PGWBI Index Evaluation Subjects: 90 female volunteers aged 25 to 55 with SDA were selected as test subjects, and the 90 female volunteers were randomly divided into 9 groups, with 10 people in each group. The aromatherapy tablets of the present invention were placed in the bedroom and used for 3 consecutive months, and the PGWBI index evaluation method was used for testing every month; PGWBI (Psychological General Well-Being Index) was developed by Harold Dupuy (1984, USA) to measure the well-being and distress of individuals, and consists of 22 health-related QOL (Quality of Life) items. This index is applicable to multiple languages ​​and countries, and divides the HRQoL of individuals into 6 areas, namely "Anxiety, Vitality, Depressed mood, Self-control, Positive well-being, and General health" for separate evaluation.

[0039] The specific test standards are as follows: 1. What was your overall mood in the past month? 5) The best; 4) Very good; 3) Mostly good; 2) Very variable; 1) Mostly bad; 0) Very bad.

[0040] 2. In the past month, have you ever felt uncomfortable or fearful about your health status due to any disease (or illness)? 0) Uncomfortable every day; 1) Uncomfortable almost every day; 2) Uncomfortable half of the time; 3) Uncomfortable sometimes, but not half of the time; 4) Rarely uncomfortable; 5) No discomfort.

[0041] 3. Have you felt depressed in the past month? 0) Yes, depressed to the point of wanting to die; 1) Yes, depressed to the point of not being interested in anything; 2) Yes, depressed almost every day; 3) Yes, depressed many times; 4) Yes, depressed occasionally; 5) No, never depressed.

[0042] 4. In the past month, did you feel you had control over your actions or emotions? 5) Yes, I had complete control; 4) Yes, I had most of the control; 3) I had some control; 2) I didn’t have much control; 1) No, I sometimes got angry and my control was not very good; 0) No, I had almost no control.

[0043] 5. Have you been emotionally stressed or sad in the past month? 0) Too sad to work or do daily life; 1) Very sad; 2) Quite sad; 3) Sometimes sad; 4) Not very sad; 5) Not sad at all.

[0044] 6. How active and energetic was your life in the past month? 5) Very active and energetic. 4) Mostly quite active. 3) Sometimes active, sometimes not. 2) Generally not active. 1) Mostly not active. 0) Not active at all.

[0045] 7. Have you ever felt depressed or sad in the past month? 5) Not at all. 4) Rarely. 3) Sometimes. 2) Most of the time. 1) Very often. 0) Always.

[0046] 8. In the past month, to what extent and for how long did you feel nervous? 0) I felt very nervous all the time. 1) I felt nervous most of the time. 2) I felt nervous a few times, although not often. 3) I felt a little nervous sometimes. 4) I didn’t feel nervous most of the time. 5) I didn’t feel nervous at all.

[0047] 9. In the past month, how happy, pleased, and satisfied were you in your life? 5) Very happy. 4) Most of the time happy. 3) Generally happy. 2) Sometimes happy, sometimes unhappy. 1) Generally unhappy. 0) Very unhappy.

[0048] 10. In the past month, have you been in good health and able to do the things you want and need to do? 5) Yes, very well. 4) Mostly good. 3) Due to health problems, sometimes I cannot do the things I want and need to do. 2) I can take care of myself. 1) I need some help from others to take care of myself. 0) I need help from others for almost everything.

[0049] 11. In the past month, have you felt regretful about life, depressed, or hopeless? 0) Desperate to the point of wanting to give up on life. 1) Very desperate. 2) Quite desperate. 3) Sometimes despairing and sad. 4) Slightly desperate. 5) Not at all desperate.

[0050] 12. In the past month, have you ever woken up feeling refreshed? 0) Not at all. 1) Rarely. 2) Sometimes. 3) Often. 4) Most of the time. 5) Always.

[0051] 13. Have you ever felt worried or concerned about your health in the past month? 0) Very worried or concerned. 1) Quite worried. 2) Somewhat worried. 3) Worried sometimes, but not seriously. 4) Not worried or concerned at all. 5) Not worried or concerned at all.

[0052] 14. In the past month, have you worried about losing control over your thoughts or actions? 5) Not at all. 4) Usually not. 3) Sometimes, but not too much. 2) Sometimes a little. 1) Sometimes quite. 0) Often very.

[0053] 15. In the past month, have you had interesting things happen every day? 0) Not at all. 1) Occasionally. 2) Sometimes. 3) Often. 4) Most of the time. 5) Always.

[0054] 16. Have you been active and serious in your life in the past month? 5) Always very active and serious in your life. 4) Mostly active and serious in your life. 3) Somewhat active and serious in your life. 2) Somewhat boring and lazy in your life. 1) Mostly boring and lazy in your life. 0) Always very boring and lazy in your life.

[0055] 17. Have you felt uneasy, worried, or confused in the past month? 0) To the point of being sick. 1) Very much. 2) Quite a bit. 3) Sometimes it bothered you. 4) Not very. 5) Not at all.

[0056] 18. Have you felt secure and confident in the past month? 0) Not at all 1) Almost never 2) Sometimes 3) Often 4) Most of the time 5) Always.

[0057] 19. Have you felt calm in the past month? 5) Always calm. 4) Mostly calm. 3) Generally calm, but sometimes very nervous. 2) Generally nervous, but sometimes very calm. 1) Mostly nervous. 0) Very nervous throughout the month.

[0058] 20. Have you had a clear mind in the past month? 0) Not at all. 1) Almost never. 2) Sometimes. 3) Often. 4) Most of the time. 5) Always.

[0059] 21. Have you ever felt tired or exhausted in the past month? 5) Not at all. 4) Rarely. 3) Sometimes. 2) Often. 1) Most of the time. 0) Always.

[0060] 22. Have you felt stressed or overwhelmed in the past month? 0) Yes, stressed to an unbearable degree. 1) Yes, quite stressed. 2) Yes, more stressed than usual. 3) Yes, about the same stress as usual. 4) Yes, slightly stressed. 5) Not stressed at all.

[0061] Each area is scored 0-5 points, and the sum of the above scores is recorded as the PGWBI index (the highest is 110 points, the lowest is 0 points, and the closer the score is to 110 points, the higher or better the quality of life). Before the test, 10 subjects in each group are asked to fill in the evaluation scores of the above 22 tests, and the respective PGWBI indexes are calculated by summing them up. Finally, the average PGWBI index of the 10 people in each group before use is calculated; after continuous use of the test samples of each group for one month, the average PGWBI index of each group after one month of use is calculated using the same statistical method; and the improvement rate (%) of the PGWBI index of each group of samples is calculated according to the following formula: Improvement rate (%) = [(average PGWBI index after 3 months of use - average PGWBI index before use) / average PGWBI index before use] × 100 The specific test results are shown in Table 2 below: Table 2 sample Average PGWBI index before use Use the average PGWBI index after 1 month Use the average PGWBI index after 2 months Use the average PGWBI index after 3 months Improvement rate / % Example 1 28 35 69 92 228 Example 2 25 33 67 93 272 Example 3 33 39 71 90 172 Comparative Example 1 30 32 37 35 16.67 Comparative Example 2 29 28 34 37 27.59 Comparative Example 3 28 27 33 36 28.57 Comparative Example 4 24 23 28 30 25 From the test results in Table 2, it can be seen that after using the aromatherapy tablets added with the fragrance composition of the present invention, the PGWBI index increased from 24-33 points to 90-93 points, and the improvement rate reached more than 172%. This shows that the aromatherapy tablets containing active fragrances can bring positive emotions to users and enhance happiness, pleasure and self-confidence.

[0062] The above embodiments are preferred implementation schemes of the present invention. In addition, the present invention may also be implemented in other ways. Any obvious replacement without departing from the concept of the present invention is within the protection scope of the present invention.

Claims

1. A seasonal affective disorder composition, characterized in that: Including 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica and bupleurum extract, and cyperus rotundus and mint extract.

2. The seasonal affective disorder composition according to claim 1, characterized in that: The invention comprises the following raw materials in percentage by mass: 0.2-5% of 3,7-dimethyloctanol, 0.5-4% of myrtenol, 1-10% of caryophyllene, 0.1-1% of L-carvone, 2-30% of angelica and bupleurum extract, 2-50% of cyperus and mint extract, and the balance is solvent.

3. The seasonal affective disorder composition according to claim 1, characterized in that: The solvent is at least one of ethanol, glycerol and propylene glycol.

4. The seasonal affective disorder composition according to claim 1, characterized in that: The preparation method of the angelica and bupleurum extract comprises the following steps: respectively crushing angelica and bupleurum into particles, adding ethanol, heating and refluxing, and concentrating under reduced pressure to an extract with a relative density of 1.15-1.35, so as to obtain the angelica and bupleurum extract.

5. The seasonal affective disorder composition according to claim 5, characterized in that: In the preparation method of the angelica and bupleurum extract, ethanol is added and heated to reflux twice; the ethanol concentration is 70-80%, the amount of ethanol added is 3-10 times the total mass of angelica and bupleurum, and each heating reflux is 2-3h.

6. The seasonal affective disorder composition according to claim 1, characterized in that: The preparation method of the cyperus rotundus and mint extract comprises the following steps: crushing cyperus rotundus and mint into particles respectively, adding water, connecting a volatile oil extractor, extracting volatile oil by steam distillation, collecting the volatile oil, filtering, collecting the filtrate, boiling the filter residue once again, and filtering; combining the two filtrates, adding ethanol to precipitate, filtering to remove solid impurities, concentrating the filtrate to a relative density of 1.08-1.28, then adding polysorbate and polyoxyethylene hydrogenated castor oil, and stirring evenly.

7. The seasonal affective disorder composition according to claim 6, characterized in that: In the preparation method of the cyperus rotundus and mint extract, the added amount of water is 10-20 times the total mass of cyperus rotundus and mint; the added amount of polysorbate is 15-25% of the mass of volatile oil; and the added amount of polyoxyethylene hydrogenated castor oil is 25-65% of the mass of volatile oil.

8. A method for preparing a seasonal affective disorder composition according to any one of 1 to 7, characterized in that: The steps include: (1) Weigh 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica sinensis bupleurum extract and cyperus rotundus mint extract according to proportion; (2) Add 3,7-dimethyloctanol, myrtenol, caryophyllene, L-carvone, angelica and bupleurum extract and cyperus rotundus extract into a container, then add a solvent, and mix well until a clear liquid is obtained, thereby obtaining a seasonal affective disorder composition.

9. An aromatherapy tablet containing a seasonal affective disorder composition, characterized in that: The aromatherapy tablet comprises the following raw materials in percentage by mass: 1-20% of a seasonal affective disorder composition, 50-90% of a carrier filler, 0.05-10% of an emulsifier, and 0.01-1% of a thickener.

10. A method for preparing an aromatherapy tablet containing a seasonal affective disorder composition as claimed in claim 9, characterized in that: The steps include: (S1) Melting the carrier filler: heating beeswax at 48-55°C until it melts, adding an oil-soluble emulsifier and stirring until it is completely blended; (S2) Pretreatment of the seasonal affective disorder composition: weighing the seasonal affective disorder composition, adding a thickener and an emulsifier, and stirring evenly; (S3) Adding the seasonal affective disorder composition: adding the treated seasonal affective disorder composition to the melted beeswax, continuing heating and stirring, until the composition is fully integrated into the beeswax and has a uniform color, taking it out while hot and pouring it into a mold, letting it stand to cool, and demolding it after solidification to obtain an aromatherapy tablet containing the seasonal affective disorder composition.

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