Diamine oxidase detection probe and kit

By providing a diamine oxidase detection probe that can develop fluorescence and disappear light absorption under diamine oxidation, the problem of difficult to effectively detect serum diamine oxidase (DAO) levels in the prior art is solved, and effective support for early diagnosis of intestinal mucosal damage is achieved.

CN119707993AActive Publication Date: 2025-03-28NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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Patent Information

Application Number
CN202411908957.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-24
Publication Date
2025-03-28
Estimated Expiration
2044-12-24

AI Technical Summary

Technical Problem

The prior art is difficult to effectively detect serum diamine oxidase (DAO) levels as a diagnostic indicator for early stages of intestinal mucosal injury, resulting in delayed diagnosis and high mortality.

Method used

A diamine oxidase detection probe with a chemical structure as shown in formula (I) is provided. The probe can fluorescence and color development, has an absorption peak in the range of 592 to 602 nm, and the absorption of diamine oxidase disappears under the oxidation of diamine oxidase. The probe is stable in structure and is suitable for diamine oxidase detection.

Benefits of technology

Through the use of this probe, effective detection of serum diamine oxidase (DAO) levels is achieved, providing a reliable method for the early diagnosis of intestinal mucosal injury, and reducing diagnostic delays and mortality.

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Abstract

The invention provides a diamine oxidase detection probe and a kit. The diamine oxidase detection probe with the chemical structure as shown in the formula (I) can perform fluorescence color development and has an absorption peak value within the range of 592-602nm, and the absorption peak value is close to 596nm. And the diamine oxidase can oxidize the diamine oxidase detection probe as shown in the formula (I), so that light absorption within the range of 592-602nm disappears. The diamine oxidase detection probe with the chemical structure as shown in the formula (I) is stable in structure and beneficial to storage. The diamine oxidase detection probe with the chemical structure shown in the formula (I) can be applied to diamine oxidase detection. And a detection method is provided for taking the serum diamine oxidase (DAO) level as an early diagnosis index of intestinal mucosal injury.
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