Mycoplasma bovis JY-22002-4 and application thereof in construction of animal model

By providing a more easy-to-cultivate Mycoplasma bovine JY-22002-4, an animal model of rabbit infection in Mycoplasma bovine was constructed, which solved the problem of lack of suitable animal models in the prior art, realized an effective tool for vaccine effectiveness evaluation, and promoted the research progress of M.bovis.

CN119709488APending Publication Date: 2025-03-28JINYUBAOLING BIO PHARMA CO LTD
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Patent Information

Application Number
CN202411754528.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-02
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The lack of suitable animal models of Mycoplasma bovis in the prior art has led to slow progress in research on M.bovis, especially in basic research and biological product development.

Method used

It provides a kind of Mycoplasma bovine JY-22002-4 and its application in constructing animal models. The clinically isolated Mycoplasma bovine JY-22002-4 uses its easier cultivation characteristics to construct a rabbit animal model of Mycoplasma bovine infection. The model animals exhibit typical symptoms such as lung consolidation, which is suitable for the evaluation of the effect of Mycoplasma bovine vaccine.

Benefits of technology

The constructed animal model was able to show typical symptoms of Mycoplasma bovis infection, providing an effective tool for the evaluation of the efficacy of Mycoplasma bovis vaccine, and promoting further in-depth research by M.bovis.

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Abstract

The invention relates to the technical field of microorganisms, in particular to Mycoplasma bovis JY-22002-4 and application of the Mycoplasma bovis JY-22002-4 to construction of an animal model. The mycoplasma bovis JY-22002-4 is obtained through clinical separation, compared with conventional mycoplasma bovis, the mycoplasma bovis JY-22002-4 is easier to culture, when the mycoplasma bovis JY-22002-4 is used for constructing a mycoplasma bovis infected rabbit animal model, the obtained model animal has typical symptoms of mycoplasma bovis infection such as pulmonary abrupt change, and the mycoplasma bovis JY-22002-4 can be used for evaluating the effect of a mycoplasma bovis vaccine. The positive significance is realized on further in-depth research of the mycoplasma bovis.
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