Preparation method of Shuilu Erwei pills

Abstract

The invention relates to a method for preparing a Chinese patent medicine, and in particular to a method for preparing Shuilu Erwei Pills; the raw materials include Gorgon Fruit and Rosa Laevigata by weight, and the preparation steps a, crushing Gorgon Fruit into powder; b, sieving Rosa Laevigata to coarsely crush, adding water to decoct twice to combine the decoction, and concentrating the filtrate into a clear paste; c, taking out part of the powder obtained in a, and taking out part of the clear paste obtained in b; d, mixing the remaining powder, the clear paste and purified water to make a soft material; e, making pills of the soft material obtained in d with a pill making machine; f, sprinkling the pills obtained in e with the reserved powder in c; g, drying the pills obtained in f in a drying device to obtain dry pills; h, preparing a polishing liquid for use; i, polishing the dried pills with the polishing liquid h, and adding a polishing agent to obtain finished pills. The preparation method of Shuilu Erwei Pills using the scheme has the advantages of improved process, high productivity, easy forming of pills, high quality of pills and good appearance.

Description

Technical Field

[0001] The invention relates to a method for preparing a Chinese patent medicine, in particular to a method for preparing Shuilu Erwei pills. Background Art

[0002] Shuilu Erwei Pills are included in the first volume of the "Medical Standards of the Ministry of Health" (Chinese Medicine Formula Preparations), with the standard number WS3-B-0041-89. Its functions and indications are to astringe sperm and stop leucorrhea. It is used for kidney deficiency, loose sperm gate, male spermatorrhea, and female leucorrhea. The prescription is 1-2 parts of Euryale ferox and 1-2 parts of Rosa laevigata. The standard preparation method is: the above two ingredients, Rosa laevigata, are decocted twice with water, the first time for 3 hours and the second time for 2 hours, the decoction is combined, filtered, and the filtrate is concentrated; Euryale ferox is crushed into fine powder, sieved, and the above concentrated solution is used to make pills, and dried. The specification is 1g per 12 pills. The standard stipulates the crushing method, pill making method and pill weight. Production according to the above method has the following disadvantages: 1. The product contains more powder and less paste, and has poor viscosity. The pill diameter is large and difficult to shape. The pill making method takes a long time to make pills, and the production efficiency is low; 2. The pill making machine using the plastic method breaks the pills into strips, the pills are not spherical, and the appearance is unqualified; 3. The dissolution time limit is unqualified and production is impossible; 4. The pills have serious color difference and poor uniformity. At the same time, the pills have poor fluidity and are difficult to package. Summary of the invention

[0003] In order to solve the above technical problems, the present invention is intended to provide a method for preparing Shuilu Erwei pills with improved process, high productivity, easy pellet forming, high pellet quality, qualified dissolution time limit and good appearance.

[0004] The preparation method of Shuilu Erwei Pills in the present scheme comprises raw materials, by weight, including 1-2 parts of Euryale ferox and 1-2 parts of Rosa laevigata fruit, and the preparation steps are as follows: a. Grind the Euryale ferox into 80-120 mesh powder for later use; b. Grind the Rosa laevigata fruit through a 0.5-1.5 cm sieve, add water and boil twice, the first time for 3 hours and the second time for 2 hours, combine the decoctions, filter, and concentrate the filtrate at 75±5°C to 85±5°C into a clear paste with a relative density of 1.10-1.30 g / ml for later use; c. Take out 2-6% of the weight of the powder obtained in a and 2-8% of the weight of the clear paste obtained in b for later use; d. Mix the remaining powder and the remaining clear paste. e. mixing with purified water in an amount of 0.1-0.4 times the weight of the powder to prepare a soft material with a moisture content of 25-55%; e. using a pill-making machine to make the soft material obtained in d into pills to prepare pills that meet the weight standard; f. sprinkling the powder reserved in c on the pills obtained in e, and rolling the pills to make them more round; g. drying the pills obtained in f in a drying device to obtain dry pills; h. adding a first polishing agent in an amount of 15-60% by weight of the clear paste to the clear paste reserved in c, and dissolving the first polishing agent to prepare a polishing liquid for use; i. polishing the dry pills obtained in g with the polishing liquid obtained in h, and adding 0.01-0.7% of a second polishing agent to obtain finished pills.

[0005] Furthermore, in the step a, the Euryale ferox portion is crushed into 100 mesh powder.

[0006] Furthermore, in the step b, the filtrate is concentrated at 80±5° C. into a clear paste with a relative density of 1.18-1.25 g / ml.

[0007] Furthermore, in step c, 3-5% of the weight of the medicine powder is taken out, and 2-6% of the weight of the clear paste is taken out.

[0008] Furthermore, in the step d, a soft material with a water content of 30-50% is prepared.

[0009] Furthermore, in the step e, the soft material is pelletized using a double-roller pelletizing machine.

[0010] Furthermore, in step f, the pills are dried using one or more microwave dryers or belt dryers at a drying temperature of 60-80° C. By improving the drying process, the problem of unqualified dissolution time after drying is solved.

[0011] Furthermore, in the step h, the weight of the first polishing agent added is 20-50% of the weight of the clear paste.

[0012] Furthermore, in step g, the second polishing agent is insect wax or talcum powder.

[0013] The advantages of the present invention are: 1. By improving the process of boiling and extracting and concentrating the fruit of golden cherry, the solubility of the fruit of golden cherry is improved, the relative density of the concentrated solution is improved, and the viscosity of the concentrated solution is increased; 2. By improving the pill-making process, the problems of difficult molding, broken soft materials, non-spherical pills, and unqualified appearance are overcome; 3. By improving the drying process, the problem of unqualified dissolution time after drying is solved; 4. By improving the shaping and polishing process, the serious color difference of the pills and the unqualified appearance are solved, the problem of the fluidity of the pills is solved, and it is convenient for packaging. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 The present invention is a process flow chart of a method for preparing Shuilu Erwei Pills. DETAILED DESCRIPTION

[0015] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments:

[0016] Example 1

[0017] The present invention provides a method for preparing Shuilu Erwei Pills, characterized in that the raw materials, by weight, include 1 part of Euryale ferox and 1 part of Rosa laevigata fruit, and the preparation steps are as follows:

[0018] a. Grind the Euryale ferox into 80-120 mesh powder for standby use; in this embodiment, grind the Euryale ferox into 100 mesh powder.

[0019] b. Crush the Rosa laevigata fruit through a 0.5-1.5 cm sieve, add water and boil twice, the first time for 3 hours and the second time for 2 hours, combine the decoctions, filter, and concentrate the filtrate at 75±5°C to 85±5°C into a clear paste with a relative density of 1.10-1.30 g / ml for later use; preferably, concentrate the filtrate at 80±5°C into a clear paste with a relative density of 1.18-1.25 g / ml.

[0020] c. Take out 2-6% of the weight of the powder obtained in a and 2-8% of the weight of the clear paste obtained in b for later use; preferably, in step c, take out 3-5% of the weight of the powder and 2-6% of the weight of the clear paste.

[0021] d. Mix the remaining medicine powder, the remaining clear paste and purified water in an amount of 0.1-0.4 times the weight of the medicine powder to prepare a soft material with a water content of 25-55%; preferably, prepare a soft material with a water content of 30-50%.

[0022] e. The soft material obtained in d is pelletized by a pelletizing machine to produce pills that meet the weight standard; preferably, the soft material is pelletized by a double-roller pelletizing machine.

[0023] f. Sprinkle the pills obtained in e with the reserved powder in c, and roll the pills to make them more round;

[0024] g. Put the pills obtained in f into a drying device for drying to obtain dried pills; (drying temperature) Preferably, the pills are dried using one or more of a microwave dryer or a belt dryer, and the drying temperature is 60-80°C.

[0025] h. Add 15-60% of the weight of the first polishing agent to the reserved clear paste in c, and dissolve it to prepare a polishing liquid for use; preferably, the weight of the first polishing agent added is 20-50% of the weight of the clear paste. In this embodiment, the first polishing agent is sucrose.

[0026] i. Polish the dried pills obtained in step g with the polishing liquid obtained in step h, and add 0.01% to 0.7% of the weight of the pills as a second polishing agent to obtain finished pills. Preferably, the second polishing agent is paraffin wax or talcum powder.

[0027] Example 2

[0028] The present invention provides a method for preparing Shuilu Erwei Pills, characterized in that the raw materials, by weight, include 2 parts of Euryale ferox and 2 parts of Rosa laevigata, and the preparation steps are as follows:

[0029] a. Grind the Euryale ferox into 100-mesh powder and set aside.

[0030] b. Crush the Rosa laevigata fruit through a 0.5 cm sieve, add water and boil twice, the first time for 3 hours and the second time for 2 hours, combine the decoctions, filter, and concentrate the filtrate at 80±5℃ into a clear paste with a relative density of 1.18 / ml.

[0031] c. Take out 3% of the weight of the powder obtained in a and 2% of the weight of the clear paste obtained in b, and set them aside.

[0032] d. Mix the remaining medicine powder, the remaining clear paste and 0.1-0.4 times the weight of the medicine powder with purified water to make a soft material with a moisture content of 30%.

[0033] e. The soft material obtained in d is pelletized using a double roller pelletizing machine to produce pills that meet the weight standards.

[0034] f. Sprinkle the pills obtained in e with the reserved powder in c, and roll the pills to make them more round.

[0035] g. Dry the pills obtained in f in a microwave dryer to obtain dry pills; the drying temperature is 60-80°C.

[0036] h. Add 20% of the weight of the first polishing agent to the reserved clear paste in c, and dissolve it to prepare a polishing liquid for use. In this embodiment, the first polishing agent is sucrose.

[0037] i. Polish the dried pills obtained in step g with the polishing liquid obtained in step h, and add a second polishing agent in an amount of 0.7% by weight of the pills to obtain finished pills. Preferably, the second polishing agent is insect wax.

[0038] Example 3

[0039] The present invention provides a method for preparing Shuilu Erwei Pills, characterized in that the raw materials, by weight, include 1 part of Euryale ferox and 1 part of Rosa laevigata fruit, and the preparation steps are as follows:

[0040] a. Grind the Euryale ferox into 100-mesh powder and set aside.

[0041] b. Crush the Rosa laevigata fruit through a 1.5 cm sieve, add water and boil twice, the first time for 3 hours and the second time for 2 hours, combine the decoctions, filter, and concentrate the filtrate at 80±5℃ into a clear paste with a relative density of 1.25g / ml for later use.

[0042] c. Take out 5% by weight of the powder obtained in a and 6% by weight of the clear paste obtained in b, and set them aside.

[0043] d. Mix the remaining medicine powder, the remaining clear paste and 0.1-0.4 times the weight of the medicine powder with purified water to make a soft material with 50% water content.

[0044] e. The soft material obtained in step d is pelletized by using a double pair of rollers to produce pills that meet the weight standard;

[0045] f. Sprinkle the pills obtained in e with the reserved powder in c, and roll the pills to make them more round.

[0046] g. Dry the pills obtained in step f in a belt dryer to obtain dry pills; the drying temperature is 60-80°C.

[0047] h. Add 50% of the weight of the first polishing agent to the reserved clear paste in c, and dissolve it to prepare a polishing liquid for use. In this embodiment, the first polishing agent is sucrose.

[0048] i. Polish the dried pills obtained in step g with the polishing liquid obtained in step h, and add 0.01% of the weight of the pills as a second polishing agent to obtain finished pills. Preferably, the second polishing agent is talcum powder.

[0049] The above is only an embodiment of the present invention, and the common knowledge such as the known specific structure and characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several modifications and improvements can be made without departing from the structure of the present invention, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent.

Claims

1. A method for preparing Shuilu Erwei Pills, characterized in that: The raw materials, by weight, include 1-2 parts of Euryale ferox and 1-2 parts of Rosa laevigata. The preparation steps are as follows: a. Grind the Euryale ferox into 80-120 mesh powder for later use; b. Crush the Rosa laevigata through a 0.5-1.5 cm sieve, add water and boil twice, the first time for 3 hours and the second time for 2 hours, combine the decoctions, filter, and concentrate the filtrate at 75±5℃ to 85±5℃ into a clear paste with a relative density of 1.10-1.30 g / ml for later use; c. Take out 2-6% of the weight of the powder obtained in step a and 2-8% of the weight of the clear paste obtained in step b for later use; d. Mix the remaining medicine powder, the remaining clear paste and purified water in an amount of 0.1-0.4 times the weight of the medicine powder to prepare a soft material with a water content of 25-55%; e. The soft material obtained in step d is pelletized by a pelletizing machine to produce pills that meet the weight standard; f. Sprinkle the pills obtained in e with the reserved powder in c, and roll the pills to make them more round; g. Put the pills obtained in f into a drying device for drying to obtain dry pills (drying temperature 60-80°C); h. Add 15-60% of the weight of the first polishing agent to the reserved clear paste in c, and dissolve it to prepare a polishing liquid for use; i. Polish the dried pills obtained in g with the polishing liquid obtained in h, and add 0.01-0.7% of the weight of the pills as a second polishing agent to obtain finished pills.

2. The method for preparing the Shuilu Erwei Pill according to claim 1, characterized in that: In the step a, the Euryale ferox portion is crushed into 100 mesh powder.

3. The method for preparing the Shuilu Erwei Pill according to claim 1, characterized in that: In the step b, the filtrate is concentrated at 80±5° C. to a clear paste with a relative density of 1.18-1.25 g / ml.

4. The method for preparing the Shuilu Erwei Pill according to claim 1, characterized in that: In the step c, 3-5% of the weight of the medicine powder is taken out, and 2-6% of the weight of the clear paste is taken out.

5. The method for preparing the Shuilu Erwei Pill according to claim 1, characterized in that: In the step d, a soft material with a water content of 30-50% is prepared.

6. The method for preparing the Shuilu Erwei Pill according to claim 1, characterized in that: In the step e, the soft material is pelletized using a double roller pelletizing machine.

7. The method for preparing the Shuilu Erwei Pill according to claim 1, characterized in that: In the step f, the pills are dried using one or more of a microwave dryer or a belt dryer, and the drying temperature is 60-80°C.

8. The method for preparing Shuilu Erwei Pills according to claim 1, characterized in that: In the step h, the weight of the first polishing agent added is 20-50% of the weight of the clear paste.

9. The method for preparing Shuilu Erwei Pills according to claim 1, characterized in that: In the step g, the second polishing agent is insect wax or talcum powder.

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