Preparation method of Kechuan pills

Abstract

The invention relates to a method for preparing a Chinese patent medicine, in particular to a method for preparing a cough and asthma pill. The method comprises physically pressing fried perilla seeds to obtain perilla seed oil and perilla seed cakes, and separating the fried perilla seeds into oil and cakes by improving the crushing process, thereby overcoming the defects of high oil content of the fried perilla seeds, difficulty in direct crushing, and low powder yield, and solving the problems of high oil content in the materials and dissolution time limit by improving the adding and mixing mode of the materials. The method for preparing the cough and asthma pills by adopting the scheme has the advantages of improved process, high productivity, easy pellet forming, high pellet quality, suitable diameter, and good appearance.

Description

Technical Field

[0001] The invention relates to a method for preparing a Chinese patent medicine, in particular to a method for preparing a cough and asthma pill. Background Art

[0002] Kechuan Pills are mainly used to stop cough and relieve asthma. They are used for colds, nasal congestion, runny nose, cough, asthma, and sputum. The prescription is 1-2 parts of ephedra (honey roasted), 1-2 parts of bitter almonds, 1-2 parts of licorice, 1-2 parts of schizonepeta, 0.5-1 parts of mulberry bark (honey roasted), and 0.5-1 parts of perilla seeds (fried). The standard preparation method is: except for licorice, schizonepeta, and perilla seeds that are crushed into fine powder, the other three herbs such as bitter almonds are decocted with water three times, the first time for 3 hours, the second and third times for 2 hours each, the decoction is combined, allowed to stand, filtered, and the filtrate is concentrated into a clear paste with a relative density of 1.33-1.35. A small amount of the clear paste and a small amount of the above powder are reserved for use. The remaining clear paste and powder are mixed evenly, dried, crushed into fine powder, and made into pills with water. A small amount of the reserved medicinal powder is used to form a mold, dried at low temperature, and polished with the reserved clear paste. The specification is 2g per 15 pills. The standard specifies the crushing method, pill-making method and pill weight. When produced in the above manner: 1. Perilla seeds (fried) contain more oil, which makes them difficult to crush during powder making and results in a low powder yield; 2. The product contains more powder than paste, and the pills have a larger diameter, making them difficult to shape. It takes a long time to make pills, and the pills are not spherical, resulting in low production efficiency; 3. The color difference is serious, and the appearance properties are unqualified; 4. After drying, the pill dissolution time limit is unqualified. Summary of the invention

[0003] In order to solve the above technical problems, the present invention is intended to provide a method for preparing cough and asthma pills with improved process, high productivity, easy pellet forming, high pellet quality, suitable diameter and good appearance.

[0004] The preparation method of the cough and asthma pills in the present scheme comprises raw materials, by weight, including 1-2 parts of honey ephedra, 1-2 parts of bitter almonds, 1-2 parts of licorice, 1-2 parts of schizonepeta, 0.5-1 parts of honey mulberry bark, and 0.5-1 parts of stir-fried perilla seeds, and the preparation steps are as follows: a, physically pressing the stir-fried perilla seeds to obtain perilla seed oil and perilla seed cake, which are set aside; b, mixing the licorice, schizonepeta and the perilla seed cake obtained in step a, and crushing them into 80-120 mesh powder, which is set aside; c. Decoction honey ephedra, bitter almond and honey mulberry bark with water for three times, the first time for 3 hours, the second and third times for 2 hours respectively, combine the decoctions, let stand, filter, and concentrate the filtrate at a temperature of 70±5℃ to 90±5℃ into a clear paste with a relative density of 1.20-1.40g / ml for later use; d. Take out 1-5% of the weight of the clear paste obtained in step c and 2-8% of the weight of the powder obtained in step b, respectively for later use; e. The perilla seed oil is stirred with 40-60% ethanol in a ratio of 1:0.8-1.5 by weight to emulsify it and obtain an emulsion for standby use; f, the remaining clear paste and the remaining medicinal powder are mixed with the emulsified oil obtained in e and purified water 0.8-1.2 times the weight of the medicinal powder to prepare a soft material with a moisture content of 25-55%; g, the soft material obtained in step f is pelletized to prepare pills that meet the weight standard; h, the medicinal powder reserved in step d is sprinkled on the pills, and the pills are rolled to be more round; i, the pills obtained in step h are dried in a drying device at 40-60° C. to obtain dried pills; j, a first polishing agent of 15-60% by weight of the clear paste is added to the reserved clear paste in step d, and the first polishing agent is dissolved to prepare a polishing liquid for standby use; k, the dried pills obtained in step i are polished with the polishing liquid obtained in step j, and a second polishing agent of 0.1%-0.7% by weight of the dried pills is added to obtain finished pills.

[0005] Furthermore, in the step b, the licorice root, the schizonepeta part and the perilla seed cake obtained in the step a are mixed and crushed into 100 mesh powder.

[0006] Furthermore, in the step c, the filtrate is concentrated into a clear paste with a relative density of 1.27-1.32 g / ml at a temperature of 80±5°C.

[0007] Furthermore, in step d, 1-3% of the weight of the obtained clear paste is taken out, and 2-5% of the weight of the obtained powder in step b is taken out.

[0008] Furthermore, in the step e, the perilla seed oil obtained in step a is stirred with 40-60% ethanol in a ratio of 1:1 by weight.

[0009] Furthermore, the specific operation method of step f is to mix the emulsified oil with 2-4.5 times the weight of the medicinal powder, pass it through a 12-20 mesh sieve, and then mix it with the remaining clear paste, the remaining medicinal powder and 0.8-1.2 times the weight of the medicinal powder. Purified water to make a soft material with a moisture content of 30-50%.

[0010] Furthermore, in step g, the soft material is pelletized by a double roller pelletizing machine; in step i, the soft material is dried by a microwave dryer or a belt dryer at a temperature of 40-60° C. By improving the drying process, the problem of unqualified dissolution time limit after drying is solved.

[0011] Furthermore, in the step j, the weight of the first polishing agent added is 20-50% of the weight of the clear paste.

[0012] Furthermore, in the step k, the second polishing agent is insect wax or talcum powder.

[0013] Furthermore, in the step f, the emulsified oil is mixed with 3 times the weight of the drug powder and passed through a 14-mesh sieve.

[0014] The invention has the following advantages: 1. By improving the pulverizing process, the fried perilla seeds are separated into oil cakes, thereby overcoming the defects of high oil content of the fried perilla seeds, difficulty in direct pulverization and low powder yield; 2. By improving the material adding and mixing method, the problem of too much oil in the materials and the dissolution time limit are solved; 3. By improving the pill making process, the defects of difficult molding, non-spherical pills and low production efficiency are overcome; 4. By improving the drying process, the problem of unqualified dissolution time limit after drying is solved; 5. By improving the shaping and polishing process, the problem of serious color difference and unqualified appearance of the pills is solved. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 The present invention is a process flow chart of a method for preparing cough and asthma pills. DETAILED DESCRIPTION

[0016] The present invention is further described in detail below with reference to the accompanying drawings and specific embodiments:

[0017] Example 1

[0018] The present invention provides a method for preparing cough and asthma pills. The raw materials, measured by weight, include 1 part of honey ephedra, 1 part of bitter almond, 1 part of licorice, 1 part of schizonepeta, 0.5 part of honey mulberry bark, and 0.5 part of stir-fried perilla seeds. The preparation steps are as follows:

[0019] a. Physically pressing the fried perilla seeds to obtain perilla seed oil and perilla seed cakes for later use; separating the fried perilla seeds into oil cakes, thereby overcoming the defects of high oil content of the fried perilla seeds, difficulty in direct crushing, and low powder yield.

[0020] b. Mix the liquorice, schizonepeta and the perilla seed cake obtained in step a, and grind them into 80-mesh powder for later use.

[0021] c. Add honey ephedra, bitter almond and honey mulberry bark into water and boil them three times, 3 hours for the first time, 2 hours for the second and third times respectively. Combine the decoctions, let stand, filter, and concentrate the filtrate into a clear paste with a relative density of 1.20-1.40g / ml at a temperature of 70±5℃, and set aside to increase viscosity and solubility.

[0022] d. Take out 1-5% of the weight of the clear paste obtained in step c and 2-8% of the weight of the powder obtained in step b, and keep them separately for later use.

[0023] e. The perilla seed oil obtained in a is stirred with 40% ethanol in a ratio of 1:0.8 by weight to emulsify the perilla seed oil to obtain an emulsion for later use.

[0024] f. Mix the remaining clear paste, the remaining medicine powder, the emulsified oil obtained in e and purified water 0.8-1.2 times the weight of the medicine powder to prepare a soft material with a water content of 25-55%.

[0025] g. pelletizing the soft material obtained in step f to produce pills that meet the weight standard.

[0026] h, sprinkle the medicine powder prepared in step d on the pills, and roll the pills to make them more round.

[0027] i. Put the pills obtained in step h into a drying device and dry them at a low temperature of 40-60° C. in a microwave dryer to obtain dried pills.

[0028] j. Add 15-60% of the weight of the first polishing agent to the prepared clear paste in step d, and dissolve it to prepare a polishing liquid for use. In this embodiment, sucrose is used as the first polishing agent.

[0029] k, polishing the dried pills obtained in step i with the polishing liquid obtained in step j, and adding 0.1%-0.7% of the weight of the dried pills with a second polishing agent to obtain finished pills. In this embodiment, talcum powder is used as the second polishing agent.

[0030] Example 2

[0031] The present invention provides a method for preparing Kechuan Pills. The raw materials, measured by weight, include 2 parts of honey ephedra, 2 parts of bitter almonds, 2 parts of licorice, 2 parts of schizonepeta, 1 part of honey mulberry bark, and 1 part of stir-fried perilla seeds. The preparation steps are as follows:

[0032] a. Physically squeeze the fried perilla seeds to obtain perilla seed oil and perilla seed cake for later use;

[0033] b. Mix the liquorice, schizonepeta and the perilla seed cake obtained in step a, and grind them into 100-mesh powder for later use;

[0034] c. Add honey ephedra, bitter almond and honey mulberry bark to water and boil for three times, the first time for 3 hours, the second and third times for 2 hours respectively, combine the decoctions, let stand, filter, and concentrate the filtrate at a temperature of 80±5℃ into a clear paste with a relative density of 1.27-1.32g / ml for later use;

[0035] d. Take out 1-3% of the weight of the clear paste obtained in step c and 2-5% of the weight of the powder obtained in step b, and keep them aside for later use;

[0036] e. stirring the perilla seed oil obtained in step a with 50% ethanol in a ratio of 1:1 by weight to emulsify the oil to obtain an emulsion for later use;

[0037] f. Mix the remaining clear paste, the remaining medicine powder, the emulsified oil obtained in e and purified water 0.8-1.2 times the weight of the medicine powder to make a soft material with a water content of 30-50%;

[0038] g, pelletizing the soft material obtained in step f to produce pills that meet the weight standard;

[0039] h, sprinkle the medicine powder prepared in step d on the pills, and roll the pills to make them more round;

[0040] i. Put the pills obtained in step h into a drying device and dry them at a medium-low temperature of 40-60° C. using a microwave dryer to obtain dried pills;

[0041] j. Add 20-50% of the weight of the first polishing agent to the reserved clear paste in step d, and dissolve it to prepare a polishing liquid for use. In this embodiment, sucrose is used as the first polishing agent.

[0042] k, polishing the dried pills obtained in step i with the polishing liquid obtained in step j, and adding 0.1%-0.7% of the weight of the dried pills with a second polishing agent to obtain finished pills. In this embodiment, the second polishing agent is paraffin wax.

[0043] Example 3

[0044] The present invention provides a method for preparing cough and asthma pills. The raw materials, measured by weight, include 1 part of honey ephedra, 1 part of bitter almond, 1 part of licorice, 1 part of schizonepeta, 0.5 part of honey mulberry bark, and 0.5 part of stir-fried perilla seeds. The preparation steps are as follows:

[0045] a. Physically press the fried perilla seeds to obtain perilla seed oil and perilla seed cake for later use.

[0046] b. Mix the liquorice, schizonepeta and the perilla seed cake obtained in step a, and grind them into 120-mesh powder for later use.

[0047] c. Add honey ephedra, bitter almond and honey mulberry bark into water and boil them three times, 3 hours for the first time, 2 hours for the second and third times respectively. Combine the decoctions, let stand, filter, and concentrate the filtrate into a clear paste with a relative density of 1.27-1.32g / ml at a temperature of 90±5℃ for later use.

[0048] d. Take out 2-3% of the weight of the clear paste obtained in step c and 5-8% of the weight of the powder obtained in step b, and keep them separately for later use.

[0049] e. The perilla seed oil obtained in a is stirred with 60% ethanol in a ratio of 1:1.5 by weight to emulsify the perilla seed oil to obtain an emulsion for later use.

[0050] f. Mix the remaining clear paste, the remaining medicine powder, the emulsified oil obtained in e and purified water 0.8 times the weight of the medicine powder to prepare a soft material with a water content of 30-55%.

[0051] g. pelletizing the soft material obtained in step f to produce pills that meet the weight standard.

[0052] h, sprinkle the medicine powder prepared in step d on the pills, and roll the pills to make them more round.

[0053] i. Put the pills obtained in step h into a drying device and dry them at a low temperature of 40-60° C. in a belt dryer to obtain dried pills.

[0054] j. Add the first polishing agent which accounts for 50% of the weight of the clear paste into the reserved clear paste in step d, and dissolve it to prepare a polishing liquid for use. In this embodiment, sucrose is used as the first polishing agent.

[0055] k, polishing the dried pills obtained in step i with the polishing liquid obtained in step j, and adding 0.1% of the second polishing agent by weight of the dried pills to obtain finished pills. In this embodiment, the second polishing agent is paraffin wax.

[0056] Example 4

[0057] The present invention provides a method for preparing Kechuan Pills. The raw materials, measured by weight, include 2 parts of honey ephedra, 2 parts of bitter almonds, 2 parts of licorice, 2 parts of schizonepeta, 1 part of honey mulberry bark, and 1 part of stir-fried perilla seeds. The preparation steps are as follows:

[0058] a. Physically squeeze the fried perilla seeds to obtain perilla seed oil and perilla seed cake for later use;

[0059] b. Mix the liquorice, schizonepeta and the perilla seed cake obtained in step a, and grind them into 100-mesh powder for later use;

[0060] c. Add honey ephedra, bitter almond and honey mulberry bark to water and boil for three times, the first time for 3 hours, the second and third times for 2 hours respectively, combine the decoctions, let stand, filter, and concentrate the filtrate at a temperature of 85±5°C into a clear paste with a relative density of 1.27-1.32g / ml for later use;

[0061] d. Take out 1-3% of the weight of the clear paste obtained in step c and 2-5% of the weight of the powder obtained in step b, and keep them aside for later use;

[0062] e. stirring the perilla seed oil obtained in step a with 40-60% ethanol in a ratio of 1:1 by weight to emulsify the oil to obtain an emulsion for later use;

[0063] f. Mix the emulsified oil with 3 times the weight of the powder, pass it through a 14-mesh sieve, and then mix it with the remaining clear paste, the remaining powder and 1.2 times the weight of the powder purified water to make a soft material with a moisture content of 30-50%.

[0064] g, pelletizing the soft material obtained in step f to produce pills that meet the weight standard;

[0065] h, sprinkle the medicine powder prepared in step d on the pills, and roll the pills to make them more round;

[0066] i. Put the pills obtained in step h into a drying device and dry them at a low temperature of 40-60° C. in a microwave dryer to obtain dried pills;

[0067] j. Add 20-50% of the weight of the first polishing agent to the prepared clear paste in step d, and dissolve it to prepare a polishing liquid for use; in this embodiment, the first polishing agent is sucrose.

[0068] k, polishing the dried pills obtained in step i with the polishing liquid obtained in step j, and adding an appropriate amount of a second polishing agent of 0.7% of the weight of the dried pills to obtain finished pills. In this embodiment, the second polishing agent is insect wax.

[0069] Example 5

[0070] The difference from Example 4 is that in step f, the emulsified oil is mixed with 2 times the weight of the medicinal powder, passed through a 12-mesh sieve, and then mixed with the remaining clear paste, the remaining medicinal powder and purified water 1.2 times the weight of the medicinal powder to prepare a soft material with a moisture content of 30-50%.

[0071] Example 6

[0072] The difference from Example 4 is that in step f, the emulsified oil is mixed with 4.5 times the weight of the medicinal powder, passed through a 20-mesh sieve, and then mixed with the remaining clear paste, the remaining medicinal powder and purified water 1 times the weight of the medicinal powder to prepare a soft material with a moisture content of 30-50%.

[0073] Example 7

[0074] The difference from Example 4 is that in step f, the emulsified oil is mixed with 3.5 times the weight of the medicinal powder, passed through a 20-mesh sieve, and then mixed with the remaining clear paste, the remaining medicinal powder and 0.8 times the weight of purified water of the medicinal powder to prepare a soft material with a moisture content of 30-50%.

[0075] Example 8

[0076] The present invention provides a method for preparing Kechuan Pills. The raw materials, measured by weight, include 2 parts of honey ephedra, 2 parts of bitter almonds, 2 parts of licorice, 2 parts of schizonepeta, 1 part of honey mulberry bark, and 1 part of stir-fried perilla seeds. The preparation steps are as follows:

[0077] a. Physically squeeze the fried perilla seeds to obtain perilla seed oil and perilla seed cake for later use;

[0078] b. Mix the liquorice, schizonepeta and the perilla seed cake obtained in step a, and grind them into 100-mesh powder for later use;

[0079] c. Add honey ephedra, bitter almond and honey mulberry bark to water and boil for three times, the first time for 3 hours, the second and third times for 2 hours respectively, combine the decoction, let it stand, filter, and concentrate the filtrate at a temperature of 85±5℃ into a clear paste with a relative density of 1.27-1.32g / ml for later use;

[0080] d. Take out 1-3% of the weight of the clear paste obtained in step c and 2-5% of the weight of the powder obtained in step b, and keep them aside for later use;

[0081] e. stirring the perilla seed oil obtained in step a with 40-60% ethanol in a ratio of 1:1 by weight to emulsify the oil to obtain an emulsion for later use;

[0082] f. Mix the emulsified oil with 3 times the weight of the powder, pass it through a 14-mesh sieve, and then mix it with the remaining clear paste, the remaining powder and 0.8-1.2 times the weight of the powder purified water to make a soft material with a moisture content of 30-50%.

[0083] g, pelletizing the soft material obtained in step f to produce pills that meet the weight standard;

[0084] h, sprinkle the medicine powder prepared in step d on the pills, and roll the pills to make them more round;

[0085] i. Put the pills obtained in step h into a drying device and dry them at a low temperature of 40-60° C. in a microwave dryer to obtain dried pills;

[0086] j. Add 20-50% of the weight of the first polishing agent to the reserved clear paste in step d, and dissolve it to prepare a polishing liquid for use. In this embodiment, sucrose is used as the first polishing agent.

[0087] k, polishing the dried pills obtained in step i with the polishing liquid obtained in step j, and adding a second polishing agent of 0.5% by weight of the dried pills to obtain finished pills. In this embodiment, the second polishing agent is paraffin wax.

[0088] The above is only an embodiment of the present invention, and the common knowledge such as the known specific structure and characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several modifications and improvements can be made without departing from the structure of the present invention, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent.

Claims

1. A method for preparing Kechuan Pills, characterized in that: The raw materials, in parts by weight, include 1-2 parts of honey ephedra, 1-2 parts of bitter almonds, 1-2 parts of licorice, 1-2 parts of schizonepeta, 0.5-1 parts of honey mulberry bark, and 0.5-1 parts of stir-fried perilla seeds. The preparation steps are as follows: a. Physically squeeze the fried perilla seeds to obtain perilla seed oil and perilla seed cake for later use; b. Mix the licorice, schizonepeta and the perilla seed cake obtained in step a, and grind them into 80-120 mesh powder for later use; c. Add honey ephedra, bitter almond and honey mulberry bark to water and boil for three times, the first time for 3 hours, the second and third times for 2 hours respectively, combine the decoctions, let stand, filter, and concentrate the filtrate at a temperature of 70±5℃ to 90±5℃ into a clear paste with a relative density of 1.20-1.40g / ml for later use; d. Take out 1-5% of the weight of the clear paste obtained in step c and 2-8% of the weight of the powder obtained in step b, and keep them aside for later use; e. stirring the perilla seed oil obtained in step a with 40-60% ethanol in a ratio of 1:0.8-1.5 by weight to emulsify the perilla seed oil to obtain an emulsion for later use; f. Mix the remaining clear paste, the remaining drug powder, the emulsified oil obtained in e and purified water 0.8-1.2 times the weight of the drug powder to make a soft material with a water content of 25-55%; g, pelletizing the soft material obtained in step f to produce pills that meet the weight standard; h, sprinkle the medicine powder prepared in step d on the pills, and roll the pills to make them more round; i. Drying the pills obtained in step h in a drying device at 40-60° C. to obtain dried pills; j, adding 15-60% of the weight of the first polishing agent to the prepared clear paste in step d, and dissolving the first polishing agent to prepare a polishing liquid for use; k, polishing the dried pills obtained in step i with the polishing liquid obtained in step j, and adding 0.1%-0.7% of the weight of the dried pills with a second polishing agent to obtain finished pills.

2. The method for preparing Kechuan Pills according to claim 1, characterized in that: In the step b, liquorice, schizonepeta and the perilla seed cake obtained in step a are mixed and crushed into 100-mesh powder.

3. The method for preparing Kechuan Pills according to claim 1, characterized in that: In the step c, the filtrate is concentrated into a clear paste with a relative density of 1.27-1.32 g / ml at a temperature of 80±5°C.

4. The method for preparing Kechuan Pills according to claim 1, characterized in that: In the step d, 1-3% of the weight of the obtained clear paste is taken out, and 2-5% of the weight of the obtained powder in step b is taken out.

5. The method for preparing Kechuan Pills according to claim 1, characterized in that: In the step e, the perilla seed oil obtained in step a is stirred with 40-60% ethanol in a ratio of 1:1 by weight.

6. The method for preparing Kechuan Pills according to claim 1, characterized in that: The specific operation method of step f is to mix the emulsified oil with 2-4.5 times the weight of the powder, pass it through a 12-20 mesh sieve, and then mix it with the remaining clear paste, the remaining powder and 0.8-1.2 times the weight of the powder purified water to make a soft material with a moisture content of 30-50%.

7. The method for preparing Kechuan Pills according to claim 1, characterized in that: In the step g, the soft material is pelletized using a double roller pelletizing machine; in the step i, the soft material is dried using a microwave dryer or a belt dryer, and the drying temperature is 40-60°C.

8. The method for preparing Kechuan Pills according to claim 1, characterized in that: In the step j, the weight of the first polishing agent added is 20-50% of the weight of the clear paste.

9. The method for preparing Kechuan Pills according to claim 1, characterized in that: In the step k, the second polishing agent is insect wax or talcum powder.

10. The method for preparing Kechuan Pills according to claim 6, characterized in that: In the step f, the emulsified oil is mixed with 3 times the weight of the drug powder and passed through a 14-mesh sieve.

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