A pharmaceutical composition for treating cancer pain and a preparation method thereof

Abstract

The present invention relates to the technical field of anesthetic drugs. The present invention provides a pharmaceutical composition for treating cancer pain and a preparation method thereof, wherein the pharmaceutical composition is prepared from the following components in parts by weight: 8-10 parts of yam root, 2-6 parts of zymophora japonica, 6-8 parts of angelica dahurica, 9-13 parts of rosa centifolia, 10-20 parts of ebony, 6-10 parts of barbata, 5-9 parts of henbane, 1-3 parts of myrrh, 1-3 parts of parsley, 4-6 parts of peach kernel, and 2-4 parts of schizonepeta tenuifolia. The pharmaceutical composition provided by the present invention can be used both internally and externally, effectively treats cancer pain, has no obvious toxic and side effects, and helps relieve the pain of cancer patients.

Description

Technical Field

[0001] The present invention relates to the technical field of anesthetic drugs, and in particular to a pharmaceutical composition for treating cancer pain and a preparation method thereof. Background Art

[0002] Cancer pain generally refers to pain related to cancer, which includes pain caused by the cancer itself and pain caused by the side effects of anti-cancer treatment. Tumors invade or compress nerve roots, nerve trunks, nerve plexuses or nerves, and invade the brain and spinal cord, all of which can cause severe pain. Pain caused during tumor treatment is also considered cancer pain. Among patients with pain, 50% to 80% of pain cannot be effectively controlled due to various reasons. It is one of the most common and feared symptoms for cancer patients.

[0003] Cancer lesions spread in the body through the bloodstream, lymphatics and other pathways, cancer lesions invade nerves, or tissues and organs are compressed by cancerous tissues, all of which can cause pain. This pain can generally be relieved through anti-cancer treatment to shrink the cancer lesions and symptomatic use of analgesics.

[0004] Traditional Chinese medicine believes that cancer pain is related to internal retention of phlegm, but existing drugs cannot suppress pain from multiple aspects such as oral administration, external use and physical conditioning. Therefore, we are looking for a drug that can effectively relieve cancer pain without obvious toxic side effects. Summary of the invention

[0005] The purpose of the present invention is to provide a pharmaceutical composition for treating cancer pain and a preparation method thereof, so as to effectively relieve cancer pain and reduce the suffering of patients.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] The invention provides a pharmaceutical composition for treating cancer pain, which is prepared from the following components in parts by weight: 8-10 parts of rhizoma sibiricum, 2-6 parts of dactylum bungeanum, 6-8 parts of angelica dahurica, 9-13 parts of osmanthus fragrans, 10-20 parts of ebony, 6-10 parts of scutellaria barbata, 5-9 parts of henbane, 1-3 parts of myrrh, 1-3 parts of parsley, 4-6 parts of peach kernel and 2-4 parts of nephrodisiac.

[0008] Preferably, it is prepared from the following components in parts by weight: 9 parts of Rhizoma Cyperi, 4 parts of Radix Zanthoxylum, 7 parts of Radix Angelicae Pubescentis, 11 parts of Rhizoma Cyperi, 15 parts of Prunus mume, 8 parts of Scutellaria barbata, 7 parts of Hyoscyamus chinensis, 2 parts of Myrrh, 2 parts of Paris polyphylla, 5 parts of Peach Kernel, and 3 parts of Cibotium wilfordii.

[0009] The present invention also provides application of the pharmaceutical composition in preparing an oral medicine for treating cancer pain.

[0010] The invention also provides an oral medicine for treating cancer pain.

[0011] The present invention also provides a method for preparing the oral medicine, comprising the following steps:

[0012] (1) Weighing and crushing the root of Sanshao, Zanthoxylum bungeanum, Angelica dahurica, Rhizoma Aucklandiae, Prunus mume, Scutellaria barbata, Hyoscyamus chinensis, Myrrha japonica, Paris polyphylla, Semen persicae, and Rhizoma Cibotii according to the proportions;

[0013] (2) soaking the mixture in water, boiling it, and filtering it to obtain a filtrate 1 and a filter residue;

[0014] (3) adding water to the filter residue and boiling it twice, and filtering to obtain filtrate 2;

[0015] (4) combining filtrate 1 and filtrate 2, and concentrating them to obtain the oral medicine.

[0016] Preferably, the particle size of the mixture in step (1) is 0.1-0.5 cm, the mass ratio of the mixture to water in step (2) is 1:8-10, the soaking time is 20-30 min, the decoction time is 15-25 min, the mass ratio of the filter residue to water in step (3) is 1:6-8, the secondary decoction time is 10-15 min, and the ratio of the oral medicine obtained after concentration in step (4) to the mixture in step (1) is 1-2 mL:1 g.

[0017] The present invention also provides application of the pharmaceutical composition in preparing an external application medicine for treating cancer pain.

[0018] The invention also provides an external application medicine for treating cancer pain.

[0019] The present invention also provides a method for preparing the external application medicine, comprising the following steps:

[0020] (1) Weighing and crushing the root of Sanqi, Zanthoxylum bungeanum, Angelica dahurica, Rhizoma Aucklandiae, Prunus mume, Scutellaria barbata, Hyoscyamus chinensis, Myrrha japonica, Paris polyphylla, Semen persicae and Rhizoma Cibotii according to the proportions, and obtaining raw material powder after grinding;

[0021] (2) The raw material powder is soaked in ethanol and then concentrated into an extract to obtain the external application medicine.

[0022] Preferably, the particle size of the raw material powder in step (1) is 100-200 meshes, the mass ratio of the raw material powder to ethanol in step (2) is 1:5-6, the soaking time is 5-10 min, and the density of the extract is 1-1.1 g / cm 3 .

[0023] The present invention provides a pharmaceutical composition for treating cancer pain and a preparation method thereof, wherein the pharmaceutical composition is prepared from the following components in parts by weight: 8-10 parts of yam root, 2-6 parts of zymophyte, 6-8 parts of angelica dahurica, 9-13 parts of rosa centifolia, 10-20 parts of ebony, 6-10 parts of barbata, 5-9 parts of henbane, 1-3 parts of myrrh, 1-3 parts of parsley, 4-6 parts of peach kernel, and 2-4 parts of schisandra chinensis. The pharmaceutical composition provided by the present invention can be used both internally and externally, effectively treats cancer pain, has no obvious toxic and side effects, and helps relieve the pain of cancer patients. DETAILED DESCRIPTION

[0024] The invention provides a pharmaceutical composition for treating cancer pain, which is prepared from the following components in parts by weight: 8-10 parts of rhizoma sibiricum, 2-6 parts of dactylum bungeanum, 6-8 parts of angelica dahurica, 9-13 parts of osmanthus fragrans, 10-20 parts of ebony, 6-10 parts of scutellaria barbata, 5-9 parts of henbane, 1-3 parts of myrrh, 1-3 parts of parsley, 4-6 parts of peach kernel and 2-4 parts of nephrodisiac.

[0025] In the present invention, the pharmaceutical composition is preferably prepared from the following components in parts by weight: 9 parts of Rhizoma Cyperi, 4 parts of Radix Zanthoxylum, 7 parts of Radix Angelicae Pubescentis, 11 parts of Rhizoma Cyperi, 15 parts of Prunus mume, 8 parts of Scutellaria barbata, 7 parts of Hyoscyamus chinensis, 2 parts of Myrrha, 2 parts of Paris polyphylla, 5 parts of Semen persicae, and 3 parts of Cibotium barometz.

[0026] The present invention also provides application of the pharmaceutical composition in preparing an oral medicine for treating cancer pain.

[0027] The invention also provides an oral medicine for treating cancer pain.

[0028] The present invention also provides a method for preparing the oral medicine, comprising the following steps:

[0029] (1) Weighing and crushing the root of Sanshao, Zanthoxylum bungeanum, Angelica dahurica, Rhizoma Aucklandiae, Prunus mume, Scutellaria barbata, Hyoscyamus chinensis, Myrrha japonica, Paris polyphylla, Semen persicae, and Rhizoma Cibotii according to the proportions;

[0030] (2) soaking the mixture in water, boiling it, and filtering it to obtain a filtrate 1 and a filter residue;

[0031] (3) adding water to the filter residue and boiling it twice, and filtering to obtain filtrate 2;

[0032] (4) combining filtrate 1 and filtrate 2, and concentrating them to obtain the oral medicine.

[0033] Preferably, the particle size of the mixture in step (1) is preferably 0.1-0.5 cm, more preferably 0.2-0.3 cm, the mass ratio of the mixture to water in step (2) is preferably 1:8-10, more preferably 1:9, the soaking time is preferably 20-30 min, more preferably 25 min, the decoction time is preferably 15-25 min, more preferably 20 min, the mass ratio of the filter residue to water in step (3) is preferably 1:6-8, more preferably 1:7, the secondary decoction time is preferably 10-15 min, more preferably 12-13 min, and the ratio of the oral drug obtained after concentration in step (4) to the mixture in step (1) is preferably 1-2 mL:1 g, more preferably 1.5 mL:1 g.

[0034] The present invention also provides application of the pharmaceutical composition in preparing an external application medicine for treating cancer pain.

[0035] The invention also provides an external application medicine for treating cancer pain.

[0036] The present invention also provides a method for preparing the external application medicine, comprising the following steps:

[0037] (1) Weighing and crushing the root of Sanqi, Zanthoxylum bungeanum, Angelica dahurica, Rhizoma Aucklandiae, Prunus mume, Scutellaria barbata, Hyoscyamus chinensis, Myrrha japonica, Paris polyphylla, Semen persicae and Rhizoma Cibotii according to the proportions, and obtaining raw material powder after grinding;

[0038] (2) The raw material powder is soaked in ethanol and then concentrated into an extract to obtain the external application medicine.

[0039] Preferably, the particle size of the raw material powder in step (1) is preferably 100-200 mesh, more preferably 150 mesh, the mass ratio of the raw material powder to ethanol in step (2) is preferably 1:5-6, more preferably 1:5.5, the soaking time is preferably 5-10 min, more preferably 7-8 min, and the density of the extract is preferably 1-1.1 g / cm 3 , more preferably 1.05 g / cm 3 .

[0040] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0041] Example 1

[0042] 1. A method for preparing an oral medicine for treating cancer pain, comprising the following steps:

[0043] (1) Weigh the raw materials according to the mass ratio of 8 g of Rhizoma Cibotii, 6 g of Rhizoma Zanthoxylum, 8 g of Angelica dahurica, 9 g of Rhizoma Cibotii, 10 g of Prunus mume, 10 g of Scutellaria barbata, 5 g of Hyoscyamus chinensis, 3 g of Myrrha, 1 g of Paris polyphylla, 6 g of Semen persica, and 2 g of Rhizoma Cibotii, and grind them to obtain a mixed material with a particle size of 0.5 cm;

[0044] (2) adding 680 g of water to the mixture and soaking it for 20 min, boiling it for 15 min, and then filtering it to obtain filtrate 1 and filter residue;

[0045] (3) adding 8 times the weight of water to the filter residue and boiling it for a second time for 15 min, and filtering to obtain filtrate 2;

[0046] (4) Filtrate 1 and filtrate 2 were combined and concentrated to obtain 136 mL of oral medication.

[0047] 2. A method for preparing an external application medicine for treating cancer pain, comprising the following steps:

[0048] (1) Weigh the raw materials according to the mass ratio of 8 g of Rhizoma Cibotii, 6 g of Radix Zanthoxylum, 8 g of Radix Angelicae Pubescentis, 9 g of Radix Aucklandiae, 10 g of Prunus mume, 10 g of Scutellaria barbata, 5 g of Hyoscyamus chinensis, 3 g of Myrrha, 1 g of Paris polyphylla, 6 g of Semen persicae, and 2 g of Rhizoma Cibotii, and grind them to obtain a mixed material with a particle size of 200 mesh;

[0049] (2) The raw powder was soaked in 408 g of ethanol for 5 min and concentrated to a density of 1.1 g / cm 3 to obtain the external application medicine.

[0050] Example 2

[0051] 1. A method for preparing an oral medicine for treating cancer pain, comprising the following steps:

[0052] (1) Weigh the raw materials according to the mass ratio of 10 g of Rhizoma Cibotii, 2 g of Zanthoxylum bungeanum, 6 g of Angelica dahurica, 13 g of Radix Aucklandiae, 20 g of Prunus mume, 6 g of Scutellaria barbata, 9 g of Hyoscyamus chinensis, 1 g of Myrrha, 3 g of Paris polyphylla, 4 g of Semen persicae, and 4 g of Psoralea corylifolia, and grind them to obtain a mixed material with a particle size of 0.1 cm;

[0053] (2) adding 624 g of water to the mixture and soaking it for 30 min, boiling it for 25 min, and then filtering it to obtain filtrate 1 and filter residue;

[0054] (3) adding 6 times the weight of water to the filter residue and boiling it for a second time for 10 min, and filtering to obtain filtrate 2;

[0055] (4) Filtrate 1 and filtrate 2 were combined and concentrated to obtain 78 mL of oral medication.

[0056] 2. A method for preparing an external application medicine for treating cancer pain, comprising the following steps:

[0057] (1) Weigh the raw materials according to the mass ratio of 10 g of Rhizoma Cibotii, 2 g of Radix Zanthoxylum bungeana, 6 g of Radix Angelicae Pubescentis, 13 g of Radix Aucklandiae, 20 g of Prunus mume, 6 g of Scutellaria barbata, 9 g of Hyoscyamus chinensis, 1 g of Myrrha, 3 g of Paris polyphylla, 4 g of Semen persicae, and 4 g of Rhizoma Cibotii, and grind them to obtain a mixture with a particle size of 100 mesh;

[0058] (2) The raw powder was soaked in 390 g of ethanol for 10 min and then concentrated to a density of 1 g / cm 3 to obtain the external application medicine.

[0059] Example 3

[0060] 1. A method for preparing an oral medicine for treating cancer pain, comprising the following steps:

[0061] (1) Weigh the raw materials according to the mass ratio of 9 g of Rhizoma Cibotii, 4 g of Rhizoma Zanthoxylum, 7 g of Angelica dahurica, 11 g of Rhizoma Cibotii, 15 g of Prunus mume, 8 g of Scutellaria barbata, 7 g of Hyoscyamus chinensis, 2 g of Myrrha, 2 g of Paris polyphylla, 5 g of Semen persicae, and 3 g of Psoralea corylifolia, and grind them to obtain a mixed material with a particle size of 0.3 cm;

[0062] (2) adding 657 g of water to the mixture and soaking it for 25 min, boiling it for 20 min, and then filtering it to obtain filtrate 1 and filter residue;

[0063] (3) adding 7 times the weight of water to the filter residue and boiling it for a second time for 13 min, and filtering to obtain filtrate 2;

[0064] (4) Filtrate 1 and filtrate 2 were combined and concentrated to obtain 110 mL of oral medication.

[0065] 2. A method for preparing an external application medicine for treating cancer pain, comprising the following steps:

[0066] (1) Weigh the raw materials according to the mass ratio of 9 g of Rhizoma Cibotii, 4 g of Radix Zanthoxylum, 7 g of Angelica dahurica, 11 g of Radix Aucklandiae, 15 g of Prunus mume, 8 g of Scutellaria barbata, 7 g of Hyoscyamus chinensis, 2 g of Myrrha, 2 g of Paris polyphylla, 5 g of Semen persicae, and 3 g of Psoralea corylifolia, and grind them to obtain a mixture with a particle size of 150 mesh;

[0067] (2) The raw powder was soaked in 401 g of ethanol for 8 min and concentrated to a density of 1.05 g / cm 3 to obtain the external application medicine.

[0068] Test example

[0069] 1. 42 patients with clinically confirmed liver cancer were selected and randomly divided into 3 groups, 14 in each group, numbered as experimental groups 1 to 3. There were no significant differences in gender, age, course of disease and severity of the disease among the groups, and they were comparable.

[0070] 2. Test method: The drugs were prepared according to the methods of Examples 1 to 3. The drug prepared by the method in each example was a single-person, single-day dosage, which was divided into two portions for use, once in the morning and once in the evening.

[0071] Among them, the patients in the experimental group 1 used the medicine prepared in Example 1, the patients in the experimental group 2 used the medicine prepared in Example 2, and the patients in the experimental group 3 used the medicine prepared in Example 3.

[0072] Oral medications should be taken after breakfast and dinner, and external medications should be used after breakfast and dinner. When using, dilute it with 10 times the mass of medical alcohol and apply it to the painful area.

[0073] 3. Criteria for judging treatment effect:

[0074] The following is formulated with reference to the World Health Organization (WHO) pain quantification VRS method and NRS method:

[0075] Complete relief: completely pain-free after treatment (grade 0), with pain reduced by more than 8 points on the NRS method;

[0076] Partial relief: The pain is significantly relieved compared with before treatment, sleep is basically not affected, and the patient can lead a normal life (Grade I). The pain on the NRS method is reduced by 5 to 7 points.

[0077] Mild relief: The pain is less severe than before treatment, but still obvious, and sleep is affected (Grade II). The pain on the NRS method is reduced by 3 to 4 points.

[0078] Ineffective: There was no pain relief compared with before treatment, and the pain reduction in the NRS method was less than 2 points.

[0079] 4. The statistical results are shown in Table 1.

[0080] Table 1

[0081] Group Experimental Group 1 Experimental Group 2 Experimental Group 3 Complete remission (people) 11 9 12 Partial remission (people) 0 3 1 Mild relief (people) 2 2 0 Invalid (person) 1 0 1

[0082] As can be seen from the above embodiments, the present invention provides a pharmaceutical composition for treating cancer pain and a preparation method thereof, wherein the pharmaceutical composition is prepared from the following components in parts by weight: 8-10 parts of yam root, 2-6 parts of zymophyte, 6-8 parts of angelica dahurica, 9-13 parts of rosa centifolia, 10-20 parts of black plum, 6-10 parts of barbata, 5-9 parts of henbane, 1-3 parts of myrrh, 1-3 parts of parsley, 4-6 parts of peach kernel, and 2-4 parts of schizonepeta tenuifolia. The pharmaceutical composition provided by the present invention can be used both internally and externally, effectively treats cancer pain, has no obvious toxic and side effects, and helps relieve the pain of cancer patients.

[0083] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A pharmaceutical composition for treating cancer pain, characterized in that: The invention is prepared from the following components in parts by weight: 8-10 parts of rhizoma strychnifoliae, 2-6 parts of dactylum bungeanum, 6-8 parts of angelica dahurica, 9-13 parts of osmanthus fragrans, 10-20 parts of ebony, 6-10 parts of scutellaria barbata, 5-9 parts of hyssop, 1-3 parts of myrrh, 1-3 parts of parsley, 4-6 parts of peach kernel and 2-4 parts of schisandra chinensis.

2. The pharmaceutical composition according to claim 1, characterized in that The invention is prepared from the following components in parts by weight: 9 parts of rhizoma strychnifoliae, 4 parts of rhizoma zymophorae, 7 parts of angelica dahurica, 11 parts of rhizoma rosae antiquarii, 15 parts of ebony, 8 parts of scutellaria barbata, 7 parts of henbane, 2 parts of myrrh, 2 parts of parsley, 5 parts of peach kernel and 3 parts of schisandra chinensis.

3. Use of the pharmaceutical composition according to claim 1 or 2 in the preparation of an oral medicament for treating cancer pain.

4. An oral medicine for treating cancer pain containing the pharmaceutical composition according to claim 1 or 2.

5. The method for preparing the oral medicine according to claim 4, characterized in that: The steps include: (1) Weighing and crushing the root of Sanshao, Zanthoxylum bungeanum, Angelica dahurica, Rhizoma Aucklandiae, Prunus mume, Scutellaria barbata, Hyoscyamus chinensis, Myrrha japonica, Paris polyphylla, Semen persicae, and Rhizoma Cibotii according to the proportions; (2) soaking the mixture in water, boiling it, and filtering it to obtain a filtrate 1 and a filter residue; (3) adding water to the filter residue and boiling it twice, and filtering to obtain filtrate 2; (4) combining filtrate 1 and filtrate 2, and concentrating them to obtain the oral medicine.

6. The preparation method according to claim 5, characterized in that: The particle size of the mixture in step (1) is 0.1-0.5 cm, the mass ratio of the mixture to water in step (2) is 1:8-10, the soaking time is 20-30 min, the decoction time is 15-25 min, the mass ratio of the filter residue to water in step (3) is 1:6-8, the secondary decoction time is 10-15 min, and the ratio of the oral medicine obtained after concentration in step (4) to the mixture in step (1) is 1-2 mL:1 g.

7. Use of the pharmaceutical composition according to claim 1 or 2 in the preparation of an external application medicine for treating cancer pain.

8. An external application medicine for treating cancer pain comprising the pharmaceutical composition according to claim 1 or 2.

9. The method for preparing the external application medicine according to claim 8, characterized in that: The steps include: (1) Weighing and crushing the root of Sanqi, Zanthoxylum bungeanum, Angelica dahurica, Rhizoma Aucklandiae, Prunus mume, Scutellaria barbata, Hyoscyamus chinensis, Myrrha japonica, Paris polyphylla, Semen persicae and Rhizoma Cibotii according to the proportions, and obtaining raw material powder after grinding; (2) The raw material powder is soaked in ethanol and then concentrated into an extract to obtain the external application medicine.

10. The preparation method according to claim 9, characterized in that: The particle size of the raw material powder in step (1) is 100-200 meshes, the mass ratio of the raw material powder to ethanol in step (2) is 1:5-6, the soaking time is 5-10 minutes, and the density of the extract is 1-1.1 g / cm 3 .