Self-expanding polyurethane foam for abdominal cavity irregular injury and preparation method of self-expanding polyurethane foam

Abstract

The invention relates to the technical field of medicine, and discloses a self-expanding polyurethane foam for abdominal irregular injury and a preparation method, the preparation method comprises the following steps: the self-expanding polyurethane foam is composed of a component A, a component B and a component C, the components A, B and C correspond to a midway abc tube and are uniformly stirred under the negative pressure of 0-(-10 pm) to be directly used, the component A in S1 is isocyanate, poloxamer and styptic powder, and the component C in S2 is one or more selected from the group consisting of isocyanate, poloxamer and styptic powder; the mass ratio of the three components is 100: (0-5): (0-30). According to the self-expanding polyurethane foam for irregular damage to the abdominal cavity and the preparation method, the related self-expanding polyurethane foam material for irregular damage to the abdominal cavity is stirred and mixed in real time during use, so that the operation mode that a traditional SPUP material is firstly used for preparing a stock solution and then is used for foaming is replaced; furthermore, the defect that the stock solution is polluted when being foamed outside a space in a battlefield environment is reduced, and the defect that the wound part of a patient is easily infected or secondarily injured is further reduced, so that the safety and reliability of the self-expanding polyurethane foam for irregular injury to the abdominal cavity in use are improved.

Description

Technical Field

[0001] The invention relates to the technical field of medicine, in particular to a self-expanding polyurethane foam with irregular abdominal injuries and a preparation method thereof. Background Art

[0002] In the pre-hospital and battlefield environments, non-compressible abdominal hemorrhage caused by trauma is the main cause of death of potentially survivable people. In the U.S. military's combat trauma data, about 50% of the deaths of rescueable wounded were caused by non-compressible abdominal hemorrhage.

[0003] For non-compressible massive abdominal hemorrhage, SPUP materials are currently commonly used for abdominal packing. SPUP materials can quickly and effectively reduce the amount of bleeding in the fatal liver trauma massive hemorrhage model, significantly improve vital signs, ensure the perfusion of important organs, maintain organ function, significantly improve the survival rate, and create conditions for subsequent definitive hemostasis treatment. However, most of the current SPUP materials are usually foamed and used as polyurethane sponges. This method has the disadvantage that the foamed polyurethane sponges are easily contaminated in the external space when used, which makes the patient's wound susceptible to infection or secondary injury. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies in the prior art, the present invention provides a self-expanding polyurethane foam for irregular abdominal injuries and a preparation method, which has the advantages of reducing the disadvantage that the original liquid is contaminated when foaming outside the space in a battlefield environment, thereby reducing the disadvantage that the patient's wound is susceptible to infection or secondary injury, and solves the problem that the foamed polyurethane sponge is easily contaminated in the external space when used, thereby causing the patient's wound to be susceptible to infection or secondary injury.

[0006] (II) Technical solution

[0007] To achieve the above-mentioned purpose, the present invention provides the following technical solution: a self-expanding polyurethane foam with irregular abdominal injuries and a preparation method thereof, which comprises the following method:

[0008] S1: It is composed of components A, B, and C, which correspond to tubes abc in the middle respectively. Stir evenly under negative pressure of 0-(-10pm) and use directly.

[0009] Preferably, the component A in S1 is isocyanate, poloxamer and hemostatic powder, and the mass ratio of the three is 100:(0-5):(0-30).

[0010] Preferably, the component B in S1 includes a mixture of a polymer polyol, a chain extender, a foaming agent, and a foam stabilizer; and the component C is thrombin or an antibacterial agent.

[0011] Preferably, the hemostatic powder can be starch, chitosan, collagen, gel, and is in the form of particles or microspheres.

[0012] Preferably, the raw material composition of B is 70%-100% polymer polyol, 0.1-5% chain extender, 2-5% foaming agent, and 0.1-3% foam stabilizer.

[0013] Preferably, the isocyanate includes one or more of 4,4'-dicyclohexylmethane diisocyanate, diphenylmethane diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and toluene diisocyanate.

[0014] Preferably, the foam stabilizer acts as an active agent for the silicone surfactant.

[0015] Preferably, the foaming agent is water.

[0016] Preferably, the chain extender includes one or more of glycerol, ethylene glycol, triethanolamine, polyethylene glycol, and sorbitol.

[0017] (III) Beneficial effects

[0018] Compared with the prior art, the present invention provides a self-expanding polyurethane foam with irregular abdominal injuries and a preparation method thereof, which has the following beneficial effects:

[0019] 1. The self-expanding polyurethane foam for irregular abdominal injuries and its preparation method, by real-time stirring and mixing the relevant self-expanding polyurethane foam materials for irregular abdominal injuries during use, replaces the traditional SPUP material operation mode of first preparing the stock solution and then foaming it, thereby reducing the disadvantage of the stock solution being contaminated when foaming outside the space in a battlefield environment, thereby reducing the disadvantage of the patient's wound being susceptible to infection or secondary injury, thereby improving the safety and reliability of the use of the self-expanding polyurethane foam for irregular abdominal injuries, to a certain extent greatly ensuring that the injured person reduces fatal liver trauma bleeding, significantly improves vital signs, ensures the perfusion of important organs, maintains organ function, significantly improves the survival rate, and creates safer and more stable conditions for subsequent definitive hemostasis treatment. DETAILED DESCRIPTION

[0020] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0021] A self-expanding polyurethane foam for irregular abdominal injuries and a preparation method thereof, comprising components A, B and C, which correspond to tubes abc in the middle respectively, wherein the weight ratio of components A:B:C is 100:(30-100):(0.1-20), wherein component A is isocyanate, poloxamer and hemostatic powder, and the mass ratio of the three is 100:(0-5):(0-30), and the above materials are stirred evenly under a negative pressure of 0-(-10pm) and used in real time.

[0022] Furthermore, component B includes: a mixture of polymer polyol, chain extender, foaming agent, and foam stabilizer; component C is thrombin or antibacterial agent. In some application scenarios, C can be omitted, or the C tube can be left empty, waiting for the operator to subsequently inject thrombin 50-200 units / ml and antibacterial agent, such as vancomycin 5-10 mg / L. (Because C is a drug, if several or one is added, it is not necessary);

[0023] Furthermore, the hemostatic powder can be starch, chitosan, collagen, gel, and be in the form of particles or microspheres.

[0024] Furthermore, the raw material composition of B is 70%-100% polymer polyol, 0.1-5% chain extender, 2-5% foaming agent, and 0.1-3% foam stabilizer.

[0025] Further, the isocyanate includes one or more of 4,4'-dicyclohexylmethane diisocyanate, diphenylmethane diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and toluene diisocyanate.

[0026] The chain extender includes one or more of propylene glycol, ethylene glycol, triethanolamine, polyethylene glycol, and sorbitol; the foam stabilizer is an organic silicon surfactant; and the foaming agent is water.

[0027] Furthermore, the chain extender includes 1,4-butanediol (BDO), 1,6-hexanediol, glycerol, trimethylolpropane, diethylene glycol (DEG), triethylene glycol, neopentyl glycol (NPG), sorbitol, diethylaminoethanol (DEAE) and the like.

[0028] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A self-expanding polyurethane foam for irregular abdominal damage and a preparation method thereof, characterized in that: The method includes the following: S1: It is composed of components A, B, and C, which correspond to tubes abc in the middle respectively. Stir evenly under negative pressure of 0-(-10pm) and use directly.

2. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method according to claim 1, characterized in that: The component A in S1 is isocyanate, poloxamer and hemostatic powder, and the mass ratio of the three is 100:(0-5):(0-30).

3. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method thereof according to claim 2, characterized in that: The component B in S1 includes a mixture of polymer polyol, chain extender, foaming agent and foam stabilizer; and the component C is thrombin or an antibacterial agent.

4. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method according to claim 3, characterized in that: The hemostatic powder can be starch, chitosan, collagen, gel, and is in the form of particles or microspheres.

5. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method according to claim 4, characterized in that: The raw material composition of B is 70%-100% of polymer polyol, 0.1-5% of chain extender, 2-5% of foaming agent and 0.1-3% of foam stabilizer.

6. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method according to claim 5, characterized in that: The isocyanate includes one or more of 4,4'-dicyclohexylmethane diisocyanate, diphenylmethane diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and toluene diisocyanate.

7. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method thereof according to claim 6, characterized in that: The foam stabilizer acts as an active agent for the silicone surface.

8. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method thereof according to claim 7, characterized in that: The foaming agent is water.

9. The self-expanding polyurethane foam for irregular abdominal injuries and the preparation method thereof according to claim 8, characterized in that: The chain extender includes one or more of glycerol, ethylene glycol, triethanolamine, polyethylene glycol, and sorbitol.