A drug application device used in the production of transdermal patches

Abstract

A drug application device for transdermal patch production, belonging to the technical field of pharmaceutical production equipment, includes a workbench, an unwinding seat, an electric winding mechanism, an electric heating drying oven, a coating roller, a guide roller, a scraper roller, a guide seat, a pressure sensor, and a motor reduction mechanism. It also includes a clearing mechanism, a control circuit, a detection circuit, and a trigger circuit. The unwinding seat, electric winding mechanism, electric heating drying oven, coating roller, guide roller, scraper roller, guide seat, pressure sensor, and motor reduction mechanism are mounted on the workbench, while the control circuit, detection circuit, and trigger circuit are installed in an electrical control box. This invention drives the coating roller to reciprocate to apply viscous medication to the transdermal patches. When the coating roller has blocked adhesive holes, it can shut off the power to the relevant equipment and automatically clear the holes through the clearing mechanism. This ensures uniform application of the viscous medication, improves the quality and production efficiency of transdermal patches, and also provides convenience for workers.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical production auxiliary equipment technology, and in particular to a drug application device used in the production of transdermal patches. Background Technology

[0002] Transdermal patches are a type of drug delivery system that is applied to the surface of intact skin. When using a transdermal patch, the user peels off the protective film and applies it to the outer side of the skin. The drug is then delivered through the skin barrier into the bloodstream to exert a systemic effect. Transdermal patch administration allows drug absorption to be unaffected by factors such as pH in the digestive tract, food, and transport time, and also avoids the first-pass effect of the liver. Transdermal patches offer flexible dosing options, allowing for long-term administration or discontinuation at any time, making them particularly suitable for infants, children, and the elderly with poor medication adherence and limited swallowing ability.

[0003] According to different types, some transdermal patches have a layer of adhesive agent adhered to the inner surface of the transdermal patch (usually non-woven fabric) (the entire inner side of the transdermal patch is on a flat plane), while others have a layer of drug protruding from the inner surface of the transdermal patch adhered to the middle of its inner side by means of heating or other methods. In current transdermal patch production, the drug-carrying surface is typically coated with the adhesive using a coating roller. Specifically, liquid medication from a high-mounted medication tank flows into the coating roller (after the medication is added, the sealing cap is closed; compressed air from the air compressor enters the medication tank through the top, ensuring appropriate pressure; this pressurized medication increases its flowability, achieving better uniform coating). The medication then flows out from multiple horizontally distributed adhesive holes at the bottom of the coating roller and is applied laterally to the transdermal patch, which moves continuously from front to back. A scraper roller at the rear of the coating roller smooths the medication (ensuring the medication is distributed as evenly as possible on the patch). Finally, the patch is dried and rolled up to obtain the finished transdermal patch. While the current method of coating the adhesive using a coating roller meets production needs to some extent, it also has some technical drawbacks due to structural limitations. Firstly, the adhesive roller is in a fixed position when applying the viscous agent. This means that the agent flowing from the lower ends of the roller's multiple nozzles cannot effectively cover the entire surface of the transdermal patch. Especially when one or more nozzles are blocked, the amount of viscous agent on the patch is relatively small, and even after the scraper roller smooths it out, it cannot guarantee complete coverage, negatively impacting the patch's quality (e.g., missing agent in one area). Secondly, the adhesive roller's nozzles are not automatically cleared, failing to promptly alert workers for maintenance. This also negatively affects the quality of transdermal patch production. Furthermore, manually shutting down the equipment to clear the nozzles is inconvenient for workers and hinders work efficiency. Summary of the Invention

[0004] To overcome the shortcomings of existing coating rollers used in transdermal patch production, which are limited by their structure and have the drawbacks described in the background, this invention provides a coating roller that can reciprocate left and right under the combined action of related mechanisms to apply viscous agents. Furthermore, when the coating roller has blocked adhesive holes, the power supply to the relevant equipment can be cut off in a timely manner, and the adhesive holes can be automatically cleared. This ensures uniform application of the viscous agent, improves the quality of transdermal patches, and also brings convenience and improves work efficiency for the staff.

[0005] The technical solution adopted by this invention to solve its technical problem is:

[0006] A transdermal patch application device includes a worktable, an unwinding unit, an electric winding mechanism, an electric heating drying oven, an adhesive roller, a guide roller, a scraper roller, a guide seat, a pressure sensor, and a motor reduction mechanism. It also includes a clearing mechanism, a control circuit, a detection circuit, and a trigger circuit. At least two unwinding units are included, each with a support hole at its upper end. The lower ends of the two unwinding units are respectively installed at the front upper part of the worktable, and the guide roller is installed at the rear end of the unwinding units. Multiple guide seats are included, each with a uniquely shaped guide hole. One guide seat is installed at the lower end of one end of the guide roller, and the lower ends of two other guide seats are installed at a distance from each other at the other end of the guide roller. Irregularly shaped connecting pipes are installed on both sides of the coating roller. These connecting pipes slide within the guide holes of multiple guide seats. One end of the connecting pipe is connected to the air inlet pipe of a pressure sensor, and the other end is connected to the liquid outlet of a solenoid valve. The liquid inlet of the solenoid valve is connected to the liquid outlet pipe at the lower end of the reagent tank via a flexible hose. The other end of the connecting pipe of the coating roller is located... A spring is fitted on the outer side of the guide seat, and a top plate is installed on the outer end of the connecting pipe at the other end. A motor reduction mechanism is installed on the rear end of the top plate, and an eccentric wheel is installed on the front end of the rotating shaft of the motor reduction mechanism. The scraper roller, the electric heating drying box, and the electric winding mechanism are installed sequentially at intervals on the rear end of the coating roller. The unblocking mechanism includes an electric push rod, a connecting plate, and an unblocking needle. The upper end of the coating roller has an opening. The cylinder of the electric push rod is installed outside the opening of the coating roller, and the push column of the electric push rod is located inside the coating roller. The connecting plate is installed laterally on the electric push rod. At the lower end of the push rod, multiple unclogging needles are installed at intervals on the lower end of the connecting plate; the control circuit, detection circuit, and trigger circuit are installed in the electrical control box. The power output terminal of the trigger circuit is electrically connected to the power input terminal of the control circuit, and the power output terminal of the control circuit is electrically connected to the power input terminal of the electric push rod; the signal output terminal of the detection circuit is electrically connected to the signal input terminal of the trigger circuit, and the control power output terminal of the trigger circuit is electrically connected to the power input terminals of the motor reduction mechanism M, the motor reduction mechanism A, and the solenoid valve.

[0007] Furthermore, the number of unclogging needles is the same as the number of glue holes on the glue coating roller.

[0008] Furthermore, the lower ends of the plurality of unblocking needles and the upper middle parts of the plurality of glue holes are respectively located on a vertical plane, and the lower ends of the unblocking needles are conical, with the outer diameter of the lower ends of the unblocking needles being smaller than the outer diameter of the glue holes.

[0009] Furthermore, the distance between the lower end of the electric heating drying oven, the scraper roller and guide roller, the lower end of the glue coating roller, and the upper end of the worktable is specified.

[0010] Furthermore, the protruding surface of the eccentric wheel contacts the top plate.

[0011] Furthermore, the electric winding mechanism includes a motor reduction mechanism A and a fixing plate. The upper middle part of the two fixing plates has a support hole. The motor reduction mechanism A is installed on the rear end of the worktable. The side end of the rotating shaft of the motor reduction mechanism A and the side end of the translucent wrapping winding drum are respectively equipped with connecting plates. The connecting plates have multiple fixing holes.

[0012] Furthermore, the control circuit includes two sets of time-controlled switches that are electrically connected, with the power input terminals of the two sets of time-controlled switches respectively connected.

[0013] Furthermore, the triggering circuit includes a time relay module, a power switch, and a relay that are electrically connected. One of the two relays is connected to the control power input terminal, the other control power input terminal of the two relays is connected to one end of the two power switches, the other end of the two power switches is connected, the power output terminal of the time relay module is connected to the positive power input terminal of the two relays, and the negative power input terminal of the two relays is connected to the negative power input terminal and the negative control power input terminal of the time relay module.

[0014] Furthermore, the detection circuit includes an adjustable resistor and a transistor that are electrically connected. One end of the adjustable resistor is connected to one end of the first resistor and one end of the second resistor. The other end of the second resistor is connected to the base of the first transistor. The collector of the first transistor is connected to the base of the second transistor. The other end of the first resistor is connected to the emitter of the first transistor.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: Under the joint action of related mechanisms, the motor reduction mechanism can drive the coating roller to reciprocate left and right via the eccentric wheel to apply the adhesive to the transdermal patch. When the coating roller is clogged with adhesive holes, the pressure sensor detects this and, under the action of the detection circuit and trigger circuit, can promptly shut off the power to the relevant equipment and automatically clear the adhesive holes through the control circuit and unblocking mechanism. This ensures the uniform application of adhesive, improves the quality of transdermal patch production, and also brings convenience to the staff and improves work efficiency. Attached Figure Description

[0016] Figure 1This is a schematic diagram of the overall structure of the present invention;

[0017] Figure 2 This is a partial structural schematic diagram of the present invention;

[0018] Figure 3 This is the circuit diagram of the present invention. Detailed Implementation

[0019] Figures 1-3As shown, a transdermal patch application device includes a workbench 1, an unwinding seat 2, an electric winding mechanism, an electric heating drying oven 3, an adhesive roller 4 (with multiple adhesive holes 41 spaced laterally at the lower end), a guide roller 5, a scraper roller 6, a power module T1, a guide seat 7, a pressure sensor T3, and a motor reduction mechanism M (a 1KW coaxial motor gear reducer). It also includes a clearing mechanism 8, a control circuit 9, a detection circuit 10, and a trigger circuit 11. There are two unwinding seats 2, each with a support hole 21 (open structure at the upper end) in the middle of its upper end. The lower ends of the two unwinding seats 2 are welded to the upper front middle of the workbench 1 on both sides. The guide roller 5 (for guiding and limiting the drug-loaded material) is located on the left and right ends... The bearing seats are fixedly installed on both sides of the upper middle part of the worktable 1 at the rear end of the unwinding seat; there are three guide seats 7, each with a rectangular guide hole 71 in the middle. The lower end of one guide seat 7 is welded to the left side of the worktable 1 at the rear end of the guide roller 5, and the lower ends of the other two guide seats 7 are welded to the right side of the worktable 1 at the rear end of the guide roller 5 at a distance from each other; a rectangular connecting pipe 42 that communicates with the inside of the left and right ends of the coating roller 4 is welded to the outside of the middle of the left and right ends, and a sealing plate is welded to the outer end of each of the two connecting pipes 42. The connecting pipes 42 on the left and right ends of the coating roller 4 slide in the guide holes 71 of the left and right end guide seats 7, respectively. A sealing plate is welded to the upper end of the left end connecting pipe 7. Internally interconnected branch pipes (located at the left outer end of one of the guide seats) are connected at their upper ends to the air inlet pipe of pressure sensor T3 via a pipe joint; a branch pipe A is welded to the middle of the connecting pipe between the other two guide seats 7, and the upper end of branch pipe A is connected to the lower end of a solenoid valve DC via a pipe joint. The upper end of the solenoid valve DC is connected to the liquid outlet pipe at the middle of the lower end of the medicine tank (not shown in the figure) via a flexible hose. A spring 43 is sleeved on the right side connecting pipe of the glue roller 4 located at the right guide seat, and a top plate 44 is welded to the rightmost part of the right side connecting pipe of the glue roller. The motor reduction mechanism M is longitudinally fixed to the workbench at the rear end of the top plate 44 by bolts, and an eccentric wheel 12 is welded to the front end of the rotating shaft of the motor reduction mechanism. The scraper roller 6, the electric heating drying box 3, and the electric winding mechanism are sequentially bolted to the workbench 1 located at the rear end of the coating roller. The unblocking mechanism includes two electric push rods M2, a connecting plate 81, and unblocking needles 82. The upper end of the coating roller 4 has two openings on the left and right. The cylinders of the two sets of electric push rods M2 are vertically sealed and installed on the two openings of the coating roller 4. The push rods of the two sets of electric push rods M2 enter the coating roller 4 through the openings. The connecting plate 81 is horizontally welded to the lower end of the push rods of the two sets of electric push rods M2. The upper ends of multiple unblocking needles 83 are welded to the lower end of the connecting plate 81 at intervals. The power module T1, the control circuit 9, the detection circuit 10, and the trigger circuit 11 are installed in the electrical control box 13 at the front end of the workbench.

[0020] Figures 1-3As shown, the number of unclogging needles 83 is the same as the number of glue holes 41 on the glue coating roller. The lower ends of multiple unclogging needles 83 and the upper middle parts of multiple glue holes 41 are respectively on a vertical plane, and the lower ends of unclogging needles 83 are conical, with the outer diameter of the lower end of unclogging needles 83 being smaller than the outer diameter of the glue holes 41. The lower end of the electric heating drying oven 3, the scraper roller 6 and guide roller 5, the lower end of the glue coating roller 4, and the upper end of the worktable 1 are spaced apart. The left side of the eccentric wheel 12 is in contact with the right side of the top plate 44. The electric winding mechanism includes a motor reduction mechanism AM1 (a finished coaxial motor gear reducer with a power of 1KW) and two fixing plates 141. Each fixing plate 141 has a support hole 1411 at its upper center. The motor reduction mechanism AM1 is bolted to the rear end of the worktable 1. A connecting plate 143 is welded to the left end of the shaft of the motor reduction mechanism AM1 and the right end of the translucent roll 142. The connecting plates 143 have multiple fixing holes arranged in a ring (for bolting the two connecting plates 143 together). The control circuit includes two sets of time switches T5 and T6 connected via circuit board wiring. The power input terminals 1 and 2 of the two sets of time switches T5 and T6 are connected respectively. The trigger circuit includes a time relay module T4, power switches S1 and S2, and relays J1 and J2 connected via circuit board wiring. One of the two relays J1 and J2 is connected to the control power input terminal. The other control power input terminal of the two relays J1 and J2 is connected to one end of the two power switches S1 and S2 respectively. The other end of the two power switches S1 and S2 is connected. The power output terminal 5 of the time relay module T4 is connected to the positive power input terminal of the two relays J1 and J2. The negative power input terminal of the two relays J1 and J2 is connected to the negative power input terminal 2 and the negative control power input terminal 4 of the time relay module T4. The detection circuit includes an adjustable resistor RP, resistors R1 and R2, and transistors Q1 and Q2 connected via circuit board wiring. One end of the adjustable resistor RP is connected to one end of the first resistor R1 and one end of the second resistor R2. The other end of the second resistor R2 is connected to the base of the first transistor Q1. The collector of the first transistor Q1 and the base of the second transistor Q2 are connected. The other end of the first resistor R1 is connected to the emitter of the first transistor Q1.

[0021] Figures 1-3As shown, the power input terminals 1 and 2 of power module T1, one of the control power input terminals of relays J1 and J2 in the trigger circuit, the other end of power switches S1 and S2, and the two poles of the 220V AC power supply are connected by wires. The power output terminals 3 and 4 of power module T1, the power input terminals 1 and 2 of pressure sensor T3, the power input terminal of transistor Q2 in the detection circuit, the emitter of resistor R1, and the negative power input terminal of relay J1 in the trigger circuit are connected by wires. The power output terminal of trigger circuit, the time relay module T4, the time relay module T4, the control circuit, and the time switch T5, the time control switch T5, the time control switch T5 and T6, the time control switch T5 and T6, the time relay module T4, and the electric push rod M2, the time relay module T4, the time relay module T4, the time relay module T4, and ... and the time relay module T4, the time relay module T4, and the time relay module T4, the time relay module T4, and the time relay module T4, the time relay module T4, and the time relay module T4, the time relay module T4, and the time relay module T4, the time relay module T4, and the time relay module T4, the time relay module T4, and the time relay module T4, the time relay module T4 The two normally closed contacts of relay J1 are connected to the power input terminal of the motor reduction mechanism M via wires. The two normally closed contacts of relay J2 are connected to the power input terminal of the motor reduction mechanism AM1 via wires. Pins 5 and 2 of the time relay module T4 are connected to the power input terminal of the solenoid valve DC via wires. Power module T1 is a finished AC 220V to DC 12V switching power supply module; adjustable resistor RP has a resistance of 10K; resistors R1 and R2 have resistances of 1K and 10K respectively; relays J1 and J2 are DC 12V; transistor Q1 is a 9013 (NPN) and transistor Q2 is a 9012 (PNP); the solenoid valve DC is a normally open valve core solenoid valve; time switches T5 and T6 are KG316 time relay modules, which have two power input terminals, two power output terminals, and seven setting buttons. Operating the seven setting buttons allows setting the output time of the two power output terminals; time relay module T4 is a Y... The YC-2S time relay module has two power input terminals, two control power input terminals, one power output terminal, and four setting buttons. Operating the four setting buttons allows setting the power output time. Each time a control power signal is input to the two control power input terminals, the power output terminal will output power. The electric push rod M2 is a 20W reciprocating electric telescopic rod. The pressure sensor T3 is a LU-THG pressure transmitter with two power input terminals and one signal output terminal. Depending on the detected pressure, the signal output terminal will output a voltage signal varying between 0-5V.

[0022] Figures 1-3As shown, before using this invention, the shafts at both ends of the feeding roller 14, which has several turns of transdermal patch material wound around it, are rotated from top to bottom and placed in the support holes 21 at the upper end of the two sets of unwinding seats 2. The shafts at both ends of the transdermal patch roll 142 are rotated from top to bottom and placed in the support holes 1411 at the middle of the upper end of the two fixing plates 141. The left end of the rotating shaft of the motor reduction mechanism AM1 and the right end connecting plate 143 of the transdermal patch roll 142 are then bolted together. Then, the front end of the transdermal patch is passed through the lower end of the guide roller 5, the lower end of the coating roller 4, and the lower end of the electric heating drying oven 3, and then wound around multiple times on the transdermal patch roll 142. After opening the valve at the lower end of the medicine tank located at the top (the DC valve core of the solenoid valve is opened), the liquid medicine in the medicine tank flows into the coating roller 4 (after the medicine is added to the medicine tank, the sealing cover is closed, and the compressed air output by the air compressor enters the medicine tank through the upper end of the medicine tank to ensure that there is a suitable pressure in the medicine tank. The pressurized medicine entering the coating roller can increase the fluidity of the medicine and achieve a better uniform coating effect). Then, the liquid medicine flows out from the multiple glue holes 41 distributed laterally at the lower end of the coating roller 4 and is applied laterally to the transdermal patch 15 that is constantly moving from front to back. The scraper roller 6 at the rear end of the coating roller scrapes the liquid medicine flat (so that the liquid medicine is distributed as evenly as possible on the transdermal patch). Finally, it is dried and wound up in the electric heating drying oven 3 to obtain the finished transdermal patch. After the main power switch is turned on, the power module T1 is powered on and operates. The stable 12V DC power output from pins 3 and 4 of the power module T1 enters the power input terminals of the detection circuit and the trigger circuit. After the voltage switches S1 and S2 are turned on, the motor reduction mechanism M and the motor reduction mechanism AM1 are powered on. After the motor reduction mechanism M is powered on, its shaft drives the eccentric wheel 12 to rotate. The convex surface of the eccentric wheel 12 pushes the glue-applying roller 4 to the left. When the convex surface of the eccentric wheel is separated from the right end of the top plate, the spring 43 will push the glue-applying roller 4 to the right. The above process is continuously repeated, and the glue-applying roller 4 can move back and forth left and right to apply the adhesive to the transdermal patch. The application area is relatively larger (the glue-applying roller 4 can move back and forth left and right, and the liquid flowing out of the glue hole can be more evenly distributed on the transdermal patch). After the motor reduction mechanism AM is powered on, it drives the drum to rotate. After application, the finished transdermal patch is wound up on the drum 142 of the electric winding mechanism.

[0023] Figures 1-3As shown, when the glue orifice of the coating roller is not blocked, the pressure detected by the pressure sensor T3 is relatively low, and the voltage signal output by its pin 3 is relatively low. This voltage signal is divided by the adjustable resistor RP and resistor R1, and the current is reduced by resistor R2, entering the base of transistor Q1 below 0.7V. Transistors Q1 and Q2 will not conduct, and the time relay module T4 will not input a positive control signal. Therefore, its pin 5 will not output power, and the subsequent motor reduction mechanism M and motor reduction mechanism AM1 will continue to be powered and work. When the glue orifice of the coating roller is blocked (due to the reduced liquid outflow inside the coating roller, the compressed air input by the air compressor will cause the internal pressure to increase), the pressure detected by the pressure sensor T3 is relatively high, and the voltage signal output by its pin 3 is relatively high. This voltage signal is divided by the adjustable resistor RP and resistor R1, and the current is reduced by resistor R2, entering the base of transistor Q1 above 0.7V. Transistor Q1 will conduct, and the collector outputs a low level, entering the base of transistor Q2. Transistor Q2 will conduct, and the collector outputs a high level, entering the base of transistor Q2. Pin 3 of the positive control signal input terminal of the intermittent relay module T4, and pin 5 of the time relay module T4 will output power for 10 seconds (time adjustable) to the power input terminals of relays J1, J2, solenoid valve DC, and time control switches T5 and T6. When solenoid valve DC is energized, the valve core closes, and the adhesive temporarily stops entering the coating roller. When relays J1 and J2 are energized, their control power input terminals and normally closed contacts open. Then, the motor reduction mechanism M and motor reduction mechanism AM1 will lose power and temporarily stop working. After the timer switch T5 is powered on, its pins 3 and 4 will output power for 5 seconds to the positive and negative power input terminals of the two sets of electric push rods M2. The push rods of the two sets of electric push rods M2 will push multiple unclogging needles 83 downward. The downward movement of the multiple metal unclogging needles 83 will unclog the multiple glue holes 41 at the bottom of the glue roller from top to bottom. After the timer switch T6 is powered on, its pins 3 and 4 will output power for 5 seconds to the positive and negative power input terminals of the two sets of electric push rods M2. The push rods of the two sets of electric push rods M2 will drive the multiple unclogging needles 83 upward. The upward movement of the multiple metal unclogging needles 83 will be spaced apart from the multiple glue holes 41 at the bottom of the glue roller. In this way, the medicine in the glue roller will be output to the transdermal patch through the multiple glue holes 41. Ten seconds later, pin 3 of the time relay module T4 stops outputting power, relays J1 and J2 lose power and do not engage, closing their control power input terminals and normally closed contacts. Motor reduction mechanisms M and AM1 regain power and begin operation. The DC solenoid valve loses power and its core opens, resuming normal continuous application of medication to the transdermal patch. After the transdermal patch on the subsequent feed roller 14 is unwound, a new feed roller 14 is installed. Then, the bolts securing the motor reduction mechanism AM1 and the take-up drum connecting plate are removed, and the new take-up drum 142 is secured for the take-up operation.As described above, when the glue application roller has a clogged glue hole, the pressure sensor detects it and, under the action of the detection circuit and trigger circuit, can promptly shut off the power to the relevant equipment. It also automatically clears the hole through the control circuit and the unblocking mechanism, thereby ensuring the uniform application of the adhesive agent, improving the quality of transdermal patches, and also bringing convenience and improving work efficiency to the staff.

[0024] The foregoing description illustrates the basic principles, main features, and advantages of the present invention. It will be apparent to those skilled in the art that the present invention is limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or basic characteristics. Therefore, the embodiments should be considered exemplary and non-limiting in all respects. The scope of the invention is defined by the appended claims rather than the foregoing description, and thus all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention.

[0025] Furthermore, it should be understood that although this specification describes the embodiments, the embodiments do not necessarily contain only one independent technical solution. This way of describing the specification is only for clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in the embodiments can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A drug application device for transdermal patch production, comprising a worktable, an unwinding seat, an electric winding mechanism, an electric heating drying oven, an adhesive roller, a guide roller, a scraper roller, a guide seat, a pressure sensor, and a motor reduction mechanism, characterized in that, It also includes a dredging mechanism, a control circuit, a detection circuit, and a trigger circuit; there are at least two unwinding seats, each with a support hole at its upper end and its lower end installed at the front of the upper end of the workbench; the guide roller is installed at the rear end of the unwinding seat; there are multiple guide seats, each with a shaped guide hole; one guide seat has its lower end installed at one end of the guide roller, and the other two guide seats have their lower ends spaced apart and installed at the other end of the guide roller; shaped connecting pipes are installed on both sides of the coating roller, and these connecting pipes slide within the guide holes of the multiple guide seats; one connecting pipe on one side of the coating roller is connected to the air inlet pipe of a pressure sensor, and the other connecting pipe on the other side is connected to the liquid outlet of a solenoid valve; the liquid inlet of the solenoid valve is connected to the liquid outlet pipe at the lower end of the reagent tank via a flexible hose; the connecting pipe on the other side of the coating roller is fitted with a spring on the outside of the guide seat, and a top plate is installed on the outside of the connecting pipe on the other side. The motor reduction mechanism is installed at the rear end of the top plate, and an eccentric wheel is installed at the front end of the motor reduction mechanism's shaft. The scraper roller, electric heating drying box, and electric winding mechanism are installed sequentially at intervals at the rear end of the coating roller. The unblocking mechanism includes an electric push rod, a connecting plate, and unblocking needles. The upper end of the coating roller has an opening. The cylinder of the electric push rod is installed outside the opening of the coating roller, and the push column of the electric push rod is located inside the coating roller. The connecting plate is installed laterally at the lower end of the push column of the electric push rod. Multiple unblocking needles are installed at intervals at the lower end of the connecting plate. The control circuit, detection circuit, and trigger circuit are installed in the electrical control box. The power output terminal of the trigger circuit is electrically connected to the power input terminal of the control circuit, and the power output terminal of the control circuit is electrically connected to the power input terminal of the electric push rod. The signal output terminal of the detection circuit is electrically connected to the signal input terminal of the trigger circuit, and the control power output terminal of the trigger circuit is electrically connected to the power input terminals of the motor reduction mechanism M, the motor reduction mechanism A, and the solenoid valve.

2. The application device for transdermal patch production according to claim 1, characterized in that, The number of unclogging needles is the same as the number of glue holes on the glue coating roller.

3. The application device for transdermal patch production according to claim 1, characterized in that, The lower ends of multiple unclogging needles and the upper middle parts of multiple glue holes are respectively on a vertical plane, and the lower ends of the unclogging needles are conical, with the outer diameter of the lower ends of the unclogging needles being smaller than the outer diameter of the glue holes.

4. The application device for transdermal patch production according to claim 1, characterized in that, The distance between the lower end of the electric heating drying oven, the scraper roller and guide roller, the lower end of the glue coating roller, and the upper end of the worktable.

5. The application device for transdermal patch production according to claim 1, characterized in that, The convex surface of the eccentric wheel contacts the top plate.

6. The medication application device for transdermal patch production according to claim 1, characterized in that, The electric winding mechanism includes a motor speed reduction mechanism A and a fixed plate. The upper middle part of the two fixed plates has support holes. The motor speed reduction mechanism A is installed on the rear end of the worktable. The side end of the rotating shaft of the motor speed reduction mechanism A and the side end of the translucent winding drum are respectively equipped with connecting plates, and the connecting plates have multiple fixing holes.

7. The application device for transdermal patch production according to claim 1, characterized in that, The control circuit includes two sets of time switches that are electrically connected, and the power input terminals of the two sets of time switches are connected respectively.

8. The application device for transdermal patch production according to claim 1, characterized in that, The trigger circuit includes an electrically connected time relay module, two power switches, and two relays. One of the control power input terminals of the two relays is connected to each other, and the other control power input terminals of the two relays are connected to one end of each of the two power switches. The other ends of the two power switches are connected to each other. The power output terminal of the time relay module is connected to the positive power input terminal of the two relays, and the negative power input terminal of the two relays is connected to the negative power input terminal and the negative control power input terminal of the time relay module.

9. The application device for transdermal patch production according to claim 1, characterized in that, The detection circuit includes an adjustable resistor and a transistor that are electrically connected. One end of the adjustable resistor is connected to one end of the first resistor and one end of the second resistor. The other end of the second resistor is connected to the base of the first transistor. The collector of the first transistor is connected to the base of the second transistor. The other end of the first resistor is connected to the emitter of the first transistor.

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