Seminiferous duct contraception device and preparation method thereof

Abstract

The invention discloses a seminiferous duct contraception device and a preparation method thereof, and relates to the technical field of medical instruments.The device structurally comprises a tubular outer wall, the tubular outer wall is filled with a sperm blocking layer and a mechanical supporting layer, and the sperm blocking structure is of a pore channel structure capable of blocking sperms; the mechanical supporting structure is a three-period minimal curved surface structure, and the combination of the two structures can prevent sperms from passing through a seminiferous duct and ensure normal passing of interstitial fluid at the same time. The device is mainly prepared through three steps of model slice design, ink configuration and 3D printing and post-treatment of the device. According to the seminiferous duct contraception device and the preparation method thereof, compared with seminiferous duct ligation, complications and fertility damage caused by epididymis deposition can be avoided, meanwhile, the implantation of the device has a smaller wound than that of the ligation, and processing and manufacturing are facilitated.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a vas deferens contraceptive device and a preparation method thereof. Background Art

[0002] At present, the main method of long-term male contraception in clinical practice is vasectomy. The principle of this operation is to establish a physical barrier in the vas deferens through surgical means to prevent sperm from passing through, thereby achieving the effect of contraception. This contraceptive method has a very high efficacy and can be reversed by vasectomy reversal. However, vasectomy also blocks the flow of tissue fluid, causing tissue fluid to accumulate in the epididymis, causing increased epididymal pressure and swelling. This condition is prone to complications such as hematoma, sperm granuloma, short-term postoperative pain and chronic pain syndrome, which can affect the quality of life of the recipient. In addition, epididymal swelling can also lead to negative effects such as decreased sperm motility, impaired chief cell function, and a significantly lower in vitro fertilization rate of sperm than normal, thereby damaging the reproductive capacity of the recipient. Even after vasectomy reversal, the pregnancy rate of the recipient is still lower than that of the normal population, reducing the reversibility of vasectomy.

[0003] How to develop a vas deferens contraceptive device and its preparation method, optimize the existing vasectomy, only block the passage of sperm while allowing the normal flow of tissue fluid, avoid complications caused by epididymal blockage, protect the fertility of the patient, improve the reversibility of contraception, and enrich the options for male contraception, has become a technical problem that needs to be urgently solved by technical personnel in this field. Summary of the invention

[0004] The purpose of the present invention is to provide a vas deferens contraceptive device and a preparation method thereof, so as to solve the problems listed in the background technology.

[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0006] The present invention discloses a vas deferens contraceptive device and a preparation method thereof, comprising a tubular outer wall, wherein the interior of the tubular outer wall is filled with a sperm barrier layer and a mechanical support layer;

[0007] The mechanical support layer is combined with the sperm barrier layer in a certain form to ensure that the device is stable and can continuously block sperm.

[0008] Preferably, the outer diameter of the tubular outer wall is 500-2000 μm, the axial length of the tubular outer wall is 500-10000 μm, and the wall thickness of the tubular outer wall is 10-100 μm.

[0009] Preferably, the sperm barrier layer is a multi-pore structure, the radial cross-section of one of the pores is one or more of a circle, an ellipse, a triangle, a quadrilateral, a pentagon, a hexagon, a polygon or other irregular shapes whose maximum size is sufficient to block the passage of sperm, and the pores are arranged in a straight line, a curve, a spiral or other irregular shapes along the axial direction;

[0010] And a plurality of the holes are combined at any spacing and in any arrangement;

[0011] The axial length of the sperm barrier layer along the tubular outer wall is 20 to 5000 μm, and the size range of the radial cross section of the channel is not greater than 2 to 6 μm.

[0012] Preferably, the mechanical support layer is a three-periodic minimal surface structure, and the mechanical support layer is one or more of Schwarz-P, Diamond, Gyroid, and Split-P;

[0013] The total axial length of the mechanical support layer along the tubular outer wall is 150-9980 μm, the wall thickness of the mechanical support layer is 35-65 μm, the porosity is 50%-85%, and the unit cell size is 150-450 μm.

[0014] Preferably, the tubular outer wall, the sperm barrier layer and the mechanical support layer are integrally printed using polymer-based materials;

[0015] The Young's modulus of the polymer-based material is 1MPa to 10GPa;

[0016] The polymer-based material is one or more of polymethyl methacrylate, polyurethane, polystyrene, polyethylene oxide, polydimethylsiloxane, and commercial printing ink.

[0017] A method for preparing a vas deferens contraceptive device comprises the following steps:

[0018] S1. Slice and design the vas deferens contraceptive device model along the radial direction;

[0019] S2, 3D printing using polymer-based materials according to the slice design;

[0020] S3, deinking and re-solidifying the prepared device to obtain the vas deferens contraceptive device.

[0021] Preferably, the slices of the vas deferens contraceptive device model described in step S1 are designed to have a thickness of 0.5-7 μm, a scanning line width of 0.2-1.5 μm, and an angle difference of 0-90° between layers of scanning lines.

[0022] Preferably, the core scanning rate of the 3D printing in step S2 is 10000-500000 μm / s, and the core laser power is 40-170 mW / cm 2 ;

[0023] The mass fraction of the polymer-based material except the printing ink is 50% to 95%;

[0024] The initiator in step S2 is one or more of 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, lithium phenyl-2,4,6-trimethylbenzoylphosphonate, benzophenone and 2,4-dimethylthioxanthone;

[0025] The mass percentage of the initiator is 0.01% to 1.5%.

[0026] Preferably, in step S3, the solvent used for deinking includes one or more of toluene, cyclohexanone, ethyl acetate, dichloromethane, propylene glycol methyl ether acetate, isopropanol, ethanol, and deionized water;

[0027] The post-curing step in step S3 is to irradiate the device with ultraviolet light for 1 to 15 minutes.

[0028] Compared with the prior art, the beneficial technical effects of the present invention are:

[0029] 1) The sperm barrier structure can block sperm from passing through the vas deferens and allow tissue fluid to pass normally, which can avoid epididymal blockage caused by traditional vasectomy, as well as a series of complications and potential damage to fertility caused by it;

[0030] 2) The mechanical support structure in the vas deferens contraceptive device of the present invention can improve the liquid circulation efficiency of the device, and at the same time give the device a certain degree of compression and shear resistance, ensuring that the device can maintain structural integrity during surgery and patient activities;

[0031] 3) The surgical incision when implanting the vas deferens contraceptive device of the present invention is smaller than that of vasectomy, and when reversing the contraceptive, only surgery is required to remove the contraceptive device, and its success rate is higher than that of vasectomy reversal.

[0032] In general, the present invention only blocks the passage of sperm and allows normal flow of tissue fluid, thereby avoiding complications caused by epididymal blockage, protecting the fertility of the patient, improving the reversibility of contraception, and improving the quality of life of the patient. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The present invention will be further described below in conjunction with the accompanying drawings.

[0034] Figure 1 This is a schematic diagram of the structure of the vas deferens contraceptive device prepared in Example 1 of the present invention;

[0035] Figure 2 This is a schematic diagram of the structure of the vas deferens contraceptive device prepared in Example 2 of the present invention;

[0036] Figure 3 This is a schematic diagram of the structure of the vas deferens contraceptive device prepared in Example 3 of the present invention;

[0037] Figure 4 This is a schematic diagram of the structure of the vas deferens contraceptive device prepared in Example 4 of the present invention;

[0038] Figure 5 This is a schematic diagram of the structure of the vas deferens contraceptive device prepared in Example 5 of the present invention;

[0039] Figure 6 This is a schematic diagram of the structure of the vas deferens contraceptive device prepared in Example 6 of the present invention;

[0040] Figure 7 It is a schematic structural diagram of the vas deferens contraceptive device prepared in Comparative Example 1 of the present invention;

[0041] Figure 8 It is a schematic structural diagram of the vas deferens contraceptive device prepared in comparative example 2 of the present invention.

[0042] Explanation of the accompanying drawings: 1. tubular outer wall; 2. mechanical support layer; 3. sperm barrier layer. DETAILED DESCRIPTION

[0043] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0044] like Figure 1-8 As shown, a vas deferens contraceptive device comprises a tubular outer wall, wherein the interior of the tubular outer wall is filled with a sperm barrier layer and a mechanical support layer; the sperm barrier layer is a hole with a horizontal interface, the maximum size of which is sufficient to prevent sperm from passing through;

[0045] The mechanical support layer is combined with the sperm barrier layer in a certain form to ensure that the device is stable and can continuously block sperm.

[0046] Specifically, the outer diameter of the tubular outer wall is 500-2000 μm, the axial length of the tubular outer wall is 500-10000 μm, and the wall thickness of the tubular outer wall is 10-100 μm.

[0047] Specifically, the sperm barrier layer is a multi-pore structure, the radial cross-section of one of the pores is one or more of a circle, an ellipse, a triangle, a quadrilateral, a pentagon, a hexagon, a polygon or other irregular shapes whose maximum size is sufficient to block the passage of sperm, and the pores are arranged in a straight line, a curve, a spiral or other irregular shape along the axial direction, and are more preferably hexagonal;

[0048] And a plurality of the holes are combined at any spacing and in any arrangement;

[0049] The axial length of the sperm barrier layer along the tubular outer wall is 20 to 500 μm, and further selected to be 100 to 400 μm; the size range of the radial cross section of the channel is not greater than 2 to 6 μm, and further selected to be 3 to 5 μm.

[0050] Specifically, the mechanical support layer is a three-periodic minimal surface structure, and the mechanical support layer is one or more of Schwarz-P, Diamond, Gyroid, and Split-P. Further, Schwarz-P and Diamond structures are preferably selected;

[0051] The total axial length of the mechanical support layer along the tubular outer wall is 150 to 9980 μm, the wall thickness of the mechanical support layer is 35 to 65 μm, further selected to be 40 to 60 μm, the porosity is 50% to 85%, further selected to be 60% to 75%; the unit cell size is 150 to 450 μm, further selected to be 200 to 400 μm.

[0052] Specifically, the tubular outer wall, the sperm barrier layer and the mechanical support layer are integrally printed using polymer-based materials;

[0053] The Young's modulus of the polymer-based material is 1MPa to 10GPa;

[0054] The polymer-based material is one or more of polymethyl methacrylate (PMMA), polyurethane (PU), polystyrene (PS), polyethylene oxide (PEO), polydimethylsiloxane (PDMS), and commercial printing ink.

[0055] A method for preparing a vas deferens contraceptive device comprises the following steps:

[0056] S1. Slice and design the vas deferens contraceptive device model along the radial direction;

[0057] S2, 3D printing using polymer-based materials according to the slice design;

[0058] S3, deinking and re-solidifying the prepared device to obtain the vas deferens contraceptive device.

[0059] Specifically, the slice thickness of the vas deferens contraceptive device model described in step S1 is designed to be 0.2-10 μm, the scanning line width is 0.1-2 μm, and the inter-layer scanning line angle difference is 0-90°.

[0060] Furthermore, the slice thickness of the vas deferens contraceptive device model is designed to be 0.5-7 μm, the scanning line width is 0.2-1.5 μm, and the scanning line angle difference between layers is 0-45°;

[0061] Furthermore, the slice thickness of the vas deferens contraceptive device model is designed to be 0.5-5 μm, the scanning line width is 0.5-1.0 μm, and the angle difference of the scanning line between layers is 0-30°.

[0062] Specifically, the core scanning rate of the 3D printing in step S2 is 10000-500000 μm / s, further 50000-40000 μm / s, and further 100000-350000 μm / s;

[0063] Core laser power is 40~170mW / cm 2 , further select 50~150mW / cm 2 , 60~120mW / cm 2 ;

[0064] The mass fraction of the polymer-based material except the printing ink is 50% to 95%; further, the mass fraction of the polymer-based material except the printing ink is 60% to 95%, and further 75% to 95%;

[0065] The initiator in step S2 is one or more of 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, lithium phenyl-2,4,6-trimethylbenzoylphosphonate, benzophenone and 2,4-dimethylthioxanthone;

[0066] The mass percentage of the initiator is 0.01% to 1.5%, further 0.05% to 1.2%, and further 0.1% to 1%;

[0067] The fluorescent dye of the printing ink is fluorescein isothiocyanate, and the concentration is 0.1-1 mg / mL. The printing ink adopts IP-S (commercial photosensitive resin, acrylic acid derivative, Nanoscribe).

[0068] Specifically, in step S3, the solvent used for deinking includes one or more of toluene, cyclohexanone, ethyl acetate, dichloromethane, propylene glycol methyl ether acetate, isopropanol, ethanol, and deionized water;

[0069] The post-curing step in step S3 is to irradiate the device with ultraviolet light for 1 to 15 minutes, preferably 1 to 10 minutes, and more preferably 2 to 7 minutes.

[0070] Embodiment 1

[0071] Use modeling software to model the device model. Figure 1 As shown, the mechanical support layer 2 adopts the Schwarz-P structure, and the sperm barrier layer 3 adopts regular hexagonal channels;

[0072] Device dimensions are a=3000; b=1400; c=200; d=1400; e=50; f=6.54; g=8.66; h=15; i=300; j=45~55; k=1000, in μm.

[0073] After building the model, save it in stl mode;

[0074] Use the slicing software matched with 3D printing to slice the model. The slicing mode is fixed mode, the slice thickness is 2μm, the scanning line width is 1μm, the inter-layer angle difference is 0°, and the slice file is saved;

[0075] Using commercial printing ink (IP-S) as raw material, using a two-photon micro-nano printer, the printing scan rate is 290000μm / s, and the core laser power is 100mW / cm 2 , print the imported slice file;

[0076] The printed device is soaked in propylene glycol methyl ether acetate, isopropyl alcohol and deionized water in sequence to remove excess ink, and the obtained device is irradiated under ultraviolet light for 5 minutes to perform a re-curing step. After the device is dried, the vas deferens contraceptive device is obtained.

[0077] Embodiment 2

[0078] Use modeling software to model the device model. Figure 2 As shown, the mechanical support layer 2 adopts a diamond structure, and the sperm barrier layer 3 adopts a perfect circular hole;

[0079] Device dimensions a=500; b=30; c=20; d=450; e=10; f=2; g=3; h=5; i=35~45; j=150; k=500, units are μm.

[0080] After building the model, save it in stl mode;

[0081] Use the slicing software matched with 3D printing to slice the model. The slicing mode is adaptive mode, the slice thickness is 0.5-3μm, the scanning line width is 0.2μm, the inter-layer angle difference is 15°, and the slice file is saved;

[0082] PMMA was used as the raw material to prepare ink, of which 50% was PMMA (mass fraction, the same below), 0.01% was 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, 49.99% was dichloromethane, and 0.1 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro-nano printer was used, and the scanning rate of printing was 10000 μm / s. The core laser power was 40 mW / cm 2 , print the imported slice file.

[0083] The printed device was soaked in dichloromethane to remove excess ink, and the device was irradiated under ultraviolet light for 1 minute to perform a re-curing step. After the device was dried, the vas deferens contraceptive device was obtained.

[0084] Embodiment 3

[0085] Use modeling software to model the device model. Figure 3 As shown, the mechanical support layer 2 adopts a Gyroid structure, and the sperm barrier layer 3 adopts an equilateral triangle channel;

[0086] Device dimensions are a=2000; b=350; c=1500; d=150; e=25; f=3; g=5; h=9; i=200; j=45~55; k=700, in μm.

[0087] After building the model, save it in stl mode;

[0088] Use the slicing software matched with 3D printing to slice the model. The slicing mode is the adaptive mode, the slice thickness is 1-5μm, the scanning line width is 0.6μm, the inter-layer angle difference is 30°, and the slice file is saved;

[0089] PU was used as the raw material to prepare the ink, of which 60% was PU (mass fraction, the same below), 0.4% was lithium phenyl 2,4,6 trimethylbenzoylphosphonate, and 39.6% was ethyl acetate. 0.3 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro-nano printer was used, and the scanning rate of the print was 100000 μm / s. The core laser power was 80 mW / cm 2 , print the imported slice file.

[0090] The printed device was soaked in ethyl acetate to remove excess ink, and the device was irradiated under ultraviolet light for 3 minutes to perform a re-curing step. After the device was dried, the vas deferens contraceptive device was obtained.

[0091] Embodiment 4

[0092] Use modeling software to model the device model. Figure 4 As shown, the mechanical support layer 2 adopts a Split-P structure, and the sperm barrier layer 3 adopts a square channel;

[0093] Device dimensions are a=5000; b=550; c=375; d=700; e=2625; f=950; g=65; h=4; i=6; j=10; k=45~55; l=250; m=750, in μm.

[0094] After building the model, save it in stl mode;

[0095] Use the slicing software matched with 3D printing to slice the model. The slicing mode is adaptive mode, the slice thickness is 3-5μm, the scanning line width is 1.2μm, the inter-layer angle difference is 45°, and the slice file is saved;

[0096] PEO was used as the raw material to prepare the ink, of which 70% was PEO (mass fraction, the same below), 0.8% was benzophenone, and 29.2% was deionized water. 0.5 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro-nano printer was used, and the scanning rate of the print was 200000 μm / s. The core laser power was 120 mW / cm 2 , print the imported slice file.

[0097] The printed device was soaked in ethanol and deionized water in turn to remove excess ink, and the device was irradiated under ultraviolet light for 7 minutes to perform a re-curing step. After the device was dried, the vas deferens contraceptive device was obtained.

[0098] Embodiment 5

[0099] Use modeling software to model the device model. Figure 5 As shown, the mechanical support layer 2 adopts the Schwarz-P structure, and the sperm barrier layer 3 adopts an elliptical channel;

[0100] Device dimensions are a=10000; b=330; c=500; d=660; e=1000; f=990; g=1500; h=1320; i=2000; j=1700; k=100; l=3; m=5; n=11; o=6; p=450; q=55~65; r=2000, units are μm.

[0101] After building the model, save it in stl mode;

[0102] Use the slicing software matched with 3D printing to slice the model. The slicing mode is adaptive mode, the slice thickness is 5-6μm, the scanning line width is 1.5μm, the inter-layer angle difference is 60°, and the slice file is saved;

[0103] PS was used as the raw material to prepare ink, of which 80% was PS (mass fraction, the same below), 1.2% was benzophenone, and 18.8% was toluene. 0.7 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro-nano printer was used, with a scanning rate of 400,000 μm / s and a core laser power of 150 mW / cm 2 , print the imported slice file.

[0104] The printed device is soaked in toluene and cyclohexanone in turn to remove excess ink, and the device is irradiated under an ultraviolet lamp for 10 minutes to perform a re-curing step. After the device is dried, the vas deferens contraceptive device is obtained.

[0105] Embodiment 6

[0106] Use modeling software to model the device model. Figure 6 As shown, the mechanical support layer 2 adopts the Schwarz-P structure, and the sperm barrier layer 3 adopts a regular pentagonal channel;

[0107] Device dimensions a=7500; b=350; c=660; d=700; e=1320; f=1050; g=2020; h=1400; i=65; j=5; k=7; l=11; m=55~65; n=400; o=1250, units are μm.

[0108] After building the model, save it in stl mode;

[0109] Use the slicing software matched with 3D printing to slice the model. The slicing mode is adaptive mode, the slice thickness is 7μm, the scanning line width is 1.5μm, the inter-layer angle difference is 90°, and the slice file is saved;

[0110] Using PDMS as the raw material, the ink was prepared, of which 95% was PDMS (mass fraction, the same below), 1.5% was 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, and 3.5% was dichloromethane. 1 mg / mL of fluorescein isothiocyanate (FITC) was added. A two-photon micro-nano printer was used, and the scanning rate of the print was 500000 μm / s. The core laser power was 170 mW / cm 2 , print the imported slice file.

[0111] The printed device was soaked in dichloromethane to remove excess ink, and the device was irradiated under ultraviolet light for 15 minutes to perform a re-curing step. After the device was dried, the vas deferens contraceptive device was obtained.

[0112] Comparative Example 1

[0113] The difference from the first embodiment is that the entire device is a sperm barrier structure. Figure 7 shown.

[0114] The difference between Comparative Example 2 and Example 1 is that the entire device is a mechanical barrier structure. Figure 8 shown.

[0115] The devices prepared in Examples 1 to 6 and Comparative Examples 1 to 2 were placed in the vas deferens of mice for testing and evaluation. The results are as follows:

[0116] Examples 1 to 6 can effectively block sperm from passing through the vas deferens in vivo, while allowing tissue fluid to pass through. After being implanted in mice for 3 months, it was found that the mouse epididymis did not swell, and the reproductive capacity of the mice was not significantly impaired. In addition, Examples 1 to 6 can maintain structural integrity when squeezed by surgery and normal activities of mice.

[0117] Since Comparative Example 1 only has a sperm barrier structure, the liquid permeability is very low during fluid simulation, and according to the mechanical simulation results, the structural integrity of the structure may be destroyed when squeezed by surgery or normal activities of mice.

[0118] Since the comparative example 2 only has a mechanical support structure, it does not have the function of blocking sperm.

[0119] As can be seen from the above embodiments, the vas deferens contraceptive device and its preparation method provided by the present invention, wherein the sperm blocking structure can allow tissue fluid to pass through the vas deferens while blocking the passage of sperm, so as to avoid complications and fertility damage caused by epididymal congestion; the mechanical support structure can improve the liquid fluid efficiency of the device while giving the device a certain pressure resistance, ensuring that the device can maintain structural integrity without damage during surgery and patient activities. Compared with existing vasectomy, the vas deferens contraceptive device can avoid related complications and protect the fertility of the patient, improve the reversibility of ligation, and at the same time, due to the small size of the device, the wound caused by surgical implantation of the device is smaller than that of vasectomy.

[0120] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0121] The embodiments described above are only descriptions of the preferred modes of the present invention, and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A vas deferens contraceptive device, comprising a tubular outer wall, characterized in that: The interior of the tubular outer wall is filled with a sperm barrier layer and a mechanical support layer; The mechanical support layer is combined with the sperm barrier layer in a certain form to ensure that the device is stable and can continuously block sperm.

2. A vas deferens contraceptive device according to claim 1, characterized in that: The outer diameter of the tubular outer wall is 500-2000 μm, the axial length of the tubular outer wall is 500-10000 μm, and the wall thickness of the tubular outer wall is 10-100 μm.

3. A vas deferens contraceptive device according to claim 1, characterized in that: The sperm barrier layer is a multi-pore structure, the radial cross-section of one of the pores is one or more of a circle, an ellipse, a triangle, a quadrilateral, a pentagon, a hexagon, a polygon or other irregular shapes whose maximum size is sufficient to block the passage of sperm, and the pores are arranged in a straight line, a curve, a spiral or other irregular shapes along the axial direction; And a plurality of the holes are combined at any spacing and in any arrangement; The axial length of the sperm barrier layer along the tubular outer wall is 20 to 5000 μm, and the size range of the radial cross section of the channel is not greater than 2 to 6 μm.

4. A vas deferens contraceptive device according to claim 1, characterized in that: The mechanical support layer is a three-periodic minimal surface structure, and the mechanical support layer is one or more of Schwarz-P, Diamond, Gyroid, and Split-P; The total axial length of the mechanical support layer along the tubular outer wall is 150-9980 μm, the wall thickness of the mechanical support layer is 35-65 μm, the porosity is 50%-85%, and the unit cell size is 150-450 μm.

5. A vas deferens contraceptive device according to claim 1, characterized in that: The tubular outer wall, the sperm barrier layer and the mechanical support layer are integrally printed using polymer-based materials; The Young's modulus of the polymer-based material is 1MPa to 10GPa; The polymer-based material is one or more of polymethyl methacrylate, polyurethane, polystyrene, polyethylene oxide, polydimethylsiloxane, and commercial printing ink.

6. A method for preparing a vas deferens contraceptive device, used for preparing a vas deferens contraceptive device according to any one of claims 1 to 5, characterized in that: The following steps are included: S1. Slice and design the vas deferens contraceptive device model along the radial direction; S2, 3D printing using polymer-based materials according to slice design; S3, deinking and re-solidifying the prepared device to obtain the vas deferens contraceptive device.

7. The method for preparing a vas deferens contraceptive device according to claim 6, characterized in that: The slice thickness of the vas deferens contraceptive device model described in step S1 is designed to be 0.5-7 μm, the scanning line width is 0.2-1.5 μm, and the angle difference of the scanning line between layers is 0-90°.

8. The method for preparing a vas deferens contraceptive device according to claim 6, characterized in that: The core scanning rate of the 3D printing in step S2 is 10000-500000 μm / s, and the core laser power is 40-170 mW / cm 2 ; The mass fraction of the polymer-based material except the printing ink is 50% to 95%; The initiator in step S2 is one or more of 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone, lithium phenyl-2,4,6-trimethylbenzoylphosphonate, benzophenone and 2,4-dimethylthioxanthone; The mass percentage of the initiator is 0.01% to 1.5%.

9. The method for preparing a vas deferens contraceptive device according to claim 6, characterized in that: In step S3, the solvent used for deinking includes one or more of toluene, cyclohexanone, ethyl acetate, dichloromethane, propylene glycol methyl ether acetate, isopropyl alcohol, ethanol, and deionized water; The post-curing step in step S3 is to irradiate the device with ultraviolet light for 1 to 15 minutes.

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