A medicated shampoo for pets and its preparation method

Abstract

The present invention relates to the field of pet washing and protecting products, and in particular to a kind of pet medicated bath shampoo and preparation method thereof, which comprises the following raw materials by weight: 20-25 parts of antimicrobial peptides, 10-20 parts of mite-repelling essential oils, 8-13 parts of amino acid surfactants, 6-9 parts of D-panthenol, 6-8 parts of modified chitosan, 0.3-0.6 parts of dodecyl dimethyl betaine, 0.8-1 parts of coconut oil diethanolamide, 0.7-0.9 parts of cocamidopropyl betaine, 0.4-0.6 parts of polyquaternium salt-39, and 60-70 parts of water. The medicated bath shampoo provided by the present invention has good antibacterial effect, enhances the compliance of pet hair, and can reduce the stress response of pets when used.

Description

Technical Field

[0001] The invention relates to the field of pet washing and protecting products, and in particular to a pet medicated bath shampoo and a preparation method thereof. Background Art

[0002] With the improvement of people's living standards and the increase in demand for spiritual sustenance, the pet industry has shown a trend of rapid development. Pets have gradually become an important part of many families and occupy an extremely important position in people's hearts. Therefore, people are paying more and more attention to the health management of pets. Among the pets, cats and dogs have the highest proportion of breeders. Cats and dogs have thick hair and like to roll on the ground. Coupled with their own body odor, they are easily contaminated with various bacteria and breed parasites. Skin diseases are a type of disease that occurs more frequently in cats and dogs clinically. They will occur all year round and the condition will recur. At present, regular cleaning and care of pets through pet shampoo can reduce the occurrence of skin diseases to a certain extent, but the effect is not significant. By adding ingredients with therapeutic and preventive effects to pet shampoo to prepare medicated bath shampoo, pets can be cleaned and prevented from skin diseases when bathing, which is increasingly accepted and recognized by people.

[0003] Patent CN101879163B discloses a pet external insecticidal shampoo and its preparation method and application. The shampoo includes an insecticidal active ingredient, a solvent, a detergent component, an adjuvant and water. The insecticidal active ingredient is a mixture of rotenone and chlorantraniliprole. The insecticide can kill or prevent external parasites such as ticks, fleas, lice, mites, etc. parasitic on pets or livestock. The surfactant used in the adjuvant of the invention is irritating. The addition of these ingredients will cause the final product to be irritating to the eyes, which may cause stress reactions in pets when used.

[0004] Patent CN114452238 discloses a pet medicated bath shampoo with a soothing effect and a preparation method thereof. The medicated bath shampoo is composed of the following components: an antifungal agent, an antibacterial agent, a soothing pheromone, a surfactant, a thickener, a chelating agent, an adjuvant, and water. The pet medicated bath shampoo of the invention can prevent and treat common skin diseases of cats, and can keep cats quiet during bathing and reduce the stress response of cats. However, the antibacterial agents used in the invention are mostly chemical antibiotics, and frequent use will produce drug resistance and reduce the antibacterial effect.

[0005] Therefore, there is an urgent need for a mild, non-irritating, and antibacterial pet medicated bath shampoo on the market. Summary of the invention

[0006] In view of the problems existing in the prior art, the purpose of the present invention is to obtain a pet medicated bath shampoo, which has good antibacterial effect, enhances the softness of pet hair, is mild and non-irritating, and can reduce the stress of pets when used.

[0007] In order to achieve the above object, the technical solution adopted by the present invention is as follows:

[0008] On one hand, the present invention provides a medicated bath shampoo for pets, which comprises the following raw materials, measured by weight: 20-25 parts of antimicrobial peptides, 10-20 parts of mite repellent essential oils, 8-13 parts of amino acid surfactants, 6-9 parts of D-panthenol, 6-8 parts of modified chitosan, 0.3-0.6 parts of dodecyl dimethyl betaine, 0.8-1 parts of coconut oil diethanolamide, 0.7-0.9 parts of cocamidopropyl betaine, 0.4-0.6 parts of polyquaternium-39, and 60-70 parts of water.

[0009] In some embodiments, the antimicrobial peptide is cecropin.

[0010] In some embodiments, the anti-mite essential oil is a composition of tea tree essential oil, eucalyptus essential oil, lemon essential oil and orange peel essential oil, and the mass ratio of the four is (0.8-1.1):(0.5-0.7):(1-1.2):1.

[0011] The linalool component in tea tree essential oil has a broad-spectrum antibacterial activity, can effectively kill a variety of pathogens, and has a good elimination effect on mites. At the same time, it can help repair damaged skin, improve skin problems such as eczema and dermatitis, and promote skin health and comfort; eucalyptus essential oil can eliminate odor, promote wound healing, and relieve stress, and can relieve the discomfort of pet bathing; lemon essential oil can promote blood circulation, relieve irritability, have a fresh smell, a long lasting fragrance, and help remove greasy skin and warts; orange peel essential oil has a calming effect, helps reduce skin inflammation and acne, and increases the gloss of hair. The present invention specifically selects the above four essential oils and compounded them according to a specific ratio to obtain a mite-repellent essential oil that can effectively relieve the stress response of pets when bathing, expel mites from pet hair, and reduce hair tangling.

[0012] In some embodiments, the method for preparing the amino acid surfactant comprises the following steps:

[0013] (1) adding palmitoylglycine, crotylamine and triethylamine to dichloromethane, stirring for 5-10 min, then adding trichloromethyl chloroformate, stirring at room temperature for 30-60 min, extracting, and column chromatography to obtain the compound;

[0014] (2) Add the compound obtained in step (1), allyl polyoxyethylene ether and azobisisobutyronitrile to anhydrous methanol, stir at 70-80° C. for 1-2 h, filter, wash and dry to obtain an amino acid surfactant.

[0015] Conventional amino acid surfactants have poor foaming properties and require multiple rinses to be rinsed clean. Although compounding with other surfactants increases foaming properties, it is easy to cause stress reactions when entering the pet's eyes. The present invention connects palmitoylglycine and crotylamine through an amide bond and successfully loads a double bond, and then grafts allyl polyoxyethylene ether. The obtained amino acid surfactant is not only easy to rinse and non-irritating, but also can promote antibacterial effects. The possible reason is that the grafted polyether segment increases foaming properties, has stronger detergency, and is easier to rinse with shampoo. At the same time, the amino acid surfactant increases the amide group and the polyether chain through a chemical bond. Under the synergistic effect of the two, the affinity of antibacterial peptides and mite repellent essential oils to pet hair can be increased, the antibacterial property can be increased, and at the same time, the fragrance lasts for a long time, reducing bacterial growth.

[0016] In some embodiments, the mass ratio of palmitoylglycine to crotonamine is 1:(0.2-0.5).

[0017] In some embodiments, the mass ratio of the compound to the allyl polyoxyethylene ether in step (2) is 1:(0.5-0.8).

[0018] The present invention limits the mass ratio of palmitoylglycine to crotylamine so that the palmitoylglycine carries a certain amount of double bonds, and further limits the mass ratio of the compound to allyl polyoxyethylene ether so that the foaming property of the amino acid surfactant is increased while avoiding stress reactions in pets.

[0019] In some embodiments, the method for preparing the modified chitosan comprises the following steps:

[0020] 1) Add collagen tripeptide, acrylic acid and phosphoric acid into DMF, react at 70-80° C. for 5-6 hours, extract, rotary evaporate and dry to obtain a modifier;

[0021] 2) Add the modifier, chitosan and catalyst obtained in step 1) into anhydrous ethanol, stir at 58-63° C. for 40-60 min, wash, filter and dry to obtain modified chitosan.

[0022] The present invention prepares a modifier by reacting collagen tripeptide with acrylic acid, and then utilizes the double bond of the modifier to react with the amino group of chitosan, thereby increasing the dispersibility of chitosan in the system, and at the same time is beneficial to increasing the softness of pet hair and further improving the antibacterial property. The possible reason is that the collagen tripeptide has good compatibility with the amino acid surfactant, which can make the modified chitosan dispersed evenly and increase the antibacterial effect. At the same time, the collagen tripeptide is a small molecule substance, which has a good repairing effect on the pet's hair, and further increases the hair's absorption of essential oils and antibacterial peptides in shampoo, further improving the antibacterial property.

[0023] In some embodiments, the mass ratio of the collagen tripeptide to acrylic acid is 1:(0.7-1).

[0024] In some embodiments, the mass ratio of the modifier to chitosan in step 2) is (0.5-0.7):1.

[0025] The invention limits the mass ratio of collagen tripeptide to acrylic acid to graft double bonds to collagen tripeptide, and limits the mass ratio of modifier to chitosan to increase the dispersibility of chitosan and avoid the decrease of the repairing effect of collagen tripeptide.

[0026] A second aspect of the present invention provides a method for preparing a pet medicated bath shampoo, comprising the following steps:

[0027] S1, stirring the mite repellent essential oil, modified chitosan and amino acid surfactant at 40-50° C. for 40-50 min, then adding D-panthenol and antimicrobial peptide and continuing stirring for 20-30 min to obtain a premix;

[0028] S2. Add dodecyl dimethyl betaine, cocoyl diethanolamide, cocamidopropyl betaine, polyquaternium-39 and water to the premix obtained in step S1, and stir at 40-50° C. for 1-2 hours to obtain a medicated bath shampoo.

[0029] Compared with the prior art, the present invention has the following beneficial effects:

[0030] 1. The present invention utilizes antimicrobial peptides, anti-mite essential oils, and amino acid surfactants, and simultaneously compounding other auxiliary agents to obtain a medicinal shampoo that has good antimicrobial effects, reduces bacterial growth, can reduce stress on pets, and increases the softness of pet hair.

[0031] 2. The present invention connects palmitoylglycine and crotylamine through an amide bond and successfully loads a double bond, and then grafts allyl polyoxyethylene ether to increase foaming properties, enhance detergency, and make shampoo easier to rinse. At the same time, the amino acid surfactant increases the amide group and the polyether chain through a chemical bond. Under the synergistic effect of the two, the affinity of the antibacterial peptide and the anti-mite essential oil to the pet hair can be increased, the antibacterial property can be increased, and at the same time, the fragrance lasts for a long time and the bacterial growth can be reduced.

[0032] 3. The present invention prepares a modifier by reacting collagen tripeptide with acrylic acid, and then utilizes the double bond of the modifier to react with the amino group of chitosan. The collagen tripeptide has good compatibility with the amino acid surfactant, which can make the modified chitosan dispersed evenly and increase the antibacterial effect. At the same time, the collagen tripeptide is a small molecule substance that has a good repairing effect on the pet's hair. In addition, it increases the hair's absorption of essential oils and antibacterial peptides in shampoo, further improving the antibacterial property. DETAILED DESCRIPTION

[0033] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0034] In the following examples and comparative examples, the compound monomers and related reagents used can be purchased from the market, among which, cecropin antimicrobial peptide was purchased from Beijing Zhongnong Yingtai Biotechnology Co., Ltd.; tea tree essential oil was purchased from Pand (Shanghai) International Trade Co., Ltd.; eucalyptus essential oil and lemon essential oil were both purchased from Poli Aromatic Pharmaceutical Technology Co., Ltd.; orange peel essential oil was purchased from Shenzhen Dingcheng Plant Flavor Co., Ltd.; coconut acid diethanolamide was purchased from Guangzhou Hengfa Chemical Co., Ltd., model 6501; cocamidopropyl betaine was purchased from Zhengzhou Chengao Chemical Products Co., Ltd., model CAB-35; polyquaternium-39 was purchased from Zhongshan Dixin Chemical Co., Ltd.

[0035] Preparation Example 1

[0036] The preparation method of amino acid surfactant-1 comprises the following steps:

[0037] (1) Add 10 g palmitoylglycine, 4 g crotylamine, and 0.5 g triethylamine to 100 ml dichloromethane, stir for 8 min, then add 0.2 g trichloromethyl chloroformate, stir at room temperature for 45 min, extract, and obtain the compound by column chromatography;

[0038] (2) Add 10 g of the compound obtained in step (1), 6 g of allyl polyoxyethylene ether and 0.1 g of azobisisobutyronitrile to 100 ml of anhydrous methanol, stir at 75° C. for 1.5 h, filter, wash and dry to obtain amino acid surfactant-1.

[0039] Preparation Example 2

[0040] The preparation method of amino acid surfactant-2 is the same as that of Preparation Example 1, except that the amount of crotylamine added is 7 g.

[0041] Preparation Example 3

[0042] The preparation method of amino acid surfactant-3 is the same as that of Preparation Example 1, except that the amount of allyl polyoxyethylene ether added is 10 g.

[0043] Preparation Example 4

[0044] The preparation method of modified chitosan-1 comprises the following steps:

[0045] 1) Add 10 g collagen tripeptide, 8 g acrylic acid and 5 ml 75 wt% phosphoric acid into 100 ml DMF, react at 75° C. for 5.5 h, extract, rotary evaporate and dry to obtain a modifier;

[0046] 2) 6 g of the modifier obtained in step 1), 10 g of chitosan and 0.15 g of sodium ethoxide were added to 100 ml of anhydrous ethanol, stirred at 60° C. for 50 min, washed, filtered and dried to obtain modified chitosan-1.

[0047] Preparation Example 5

[0048] The preparation method of modified chitosan-2 is the same as that of Preparation Example 4, except that the amount of acrylic acid added is 12 g.

[0049] Preparation Example 6

[0050] The preparation method of modified chitosan-3 is the same as that of Preparation Example 4, except that the amount of the modifier added is 8.5 g.

[0051] Example 1

[0052] A pet medicated bath shampoo, comprising the following raw materials, by weight: 23 parts of cecropin antibacterial peptide, 15 parts of mite repellent essential oil, 10 parts of amino acid surfactant-1, 7.5 parts of D-panthenol, 7 parts of modified chitosan-1, 0.4 parts of dodecyl dimethyl betaine, 0.9 parts of coconut oil diethanolamide, 0.8 parts of cocamidopropyl betaine, 0.5 parts of polyquaternium-39, and 65 parts of deionized water;

[0053] Among them, the anti-mite essential oil is a combination of tea tree essential oil, eucalyptus essential oil, lemon essential oil and orange peel essential oil, and the mass ratio of the four is 1:0.6:1.1:1.

[0054] The preparation method of the pet medicated bath shampoo in this embodiment comprises the following steps:

[0055] S1, stirring the mite repellent essential oil, modified chitosan-1 and amino acid surfactant-1 at 45° C. for 45 min, then adding D-panthenol and cecropin antimicrobial peptide and continuing stirring for 25 min to obtain a premix;

[0056] S2. Add dodecyl dimethyl betaine, cocoyl diethanolamide, cocamidopropyl betaine, polyquaternium-39 and deionized water to the premix obtained in step S1, and stir at 45° C. for 1.5 hours to obtain a medicated bath shampoo.

[0057] Example 2

[0058] A pet medicated bath shampoo, comprising the following raw materials, by weight: 20 parts of cecropin antibacterial peptide, 10 parts of mite repellent essential oil, 8 parts of amino acid surfactant-1, 6 parts of D-panthenol, 6 parts of modified chitosan-1, 0.3 parts of dodecyl dimethyl betaine, 0.8 parts of coconut oil diethanolamide, 0.7 parts of cocamidopropyl betaine, 0.4 parts of polyquaternium-39, and 60 parts of deionized water;

[0059] Among them, the anti-mite essential oil is a combination of tea tree essential oil, eucalyptus essential oil, lemon essential oil and orange peel essential oil, and the mass ratio of the four is 0.8:0.5:1:1.

[0060] The preparation method of the pet medicated bath shampoo in this embodiment comprises the following steps:

[0061] S1, stirring the mite repellent essential oil, modified chitosan-1 and amino acid surfactant-1 at 40° C. for 50 min, then adding D-panthenol and cecropin antimicrobial peptide and continuing stirring for 20 min to obtain a premix;

[0062] S2. Add dodecyl dimethyl betaine, cocoyl diethanolamide, cocamidopropyl betaine, polyquaternium-39 and deionized water to the premix obtained in step S1, and stir at 40° C. for 2 h to obtain a medicated bath shampoo.

[0063] Example 3

[0064] A pet medicated bath shampoo, comprising the following raw materials, by weight: 25 parts of cecropin antibacterial peptide, 20 parts of mite repellent essential oil, 13 parts of amino acid surfactant-1, 9 parts of D-panthenol, 8 parts of modified chitosan-1, 0.6 parts of dodecyl dimethyl betaine, 1 part of coconut oil diethanolamide, 0.9 parts of cocamidopropyl betaine, 0.6 parts of polyquaternium-39, and 70 parts of deionized water;

[0065] Among them, the anti-mite essential oil is a combination of tea tree essential oil, eucalyptus essential oil, lemon essential oil and orange peel essential oil, and the mass ratio of the four is 1.1:0.7:1.2:1.

[0066] The preparation method of the pet medicated bath shampoo in this embodiment comprises the following steps:

[0067] S1, stirring the mite repellent essential oil, modified chitosan-1 and amino acid surfactant-1 at 50° C. for 40 min, then adding D-panthenol and cecropin antimicrobial peptide and continuing stirring for 30 min to obtain a premix;

[0068] S2. Add dodecyl dimethyl betaine, cocoyl diethanolamide, cocamidopropyl betaine, polyquaternium-39 and deionized water to the premix obtained in step S1, and stir at 50° C. for 1 h to obtain a medicated bath shampoo.

[0069] Example 4

[0070] A pet medicated bath shampoo and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that an equal amount of amino acid surfactant-1 is replaced by amino acid surfactant-2.

[0071] Example 5

[0072] A medicated bath shampoo for pets and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that an equal amount of amino acid surfactant-1 is replaced by amino acid surfactant-3.

[0073] Example 6

[0074] A medicated bath shampoo for pets and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that an equal amount of modified chitosan-1 is replaced by modified chitosan-2.

[0075] Example 7

[0076] A medicated bath shampoo for pets and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that an equal amount of modified chitosan-1 is replaced by modified chitosan-3.

[0077] Example 8

[0078] A medicated bath shampoo for pets and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that an equal amount of amino acid surfactant-1 is replaced by palmitoyl glycine.

[0079] Comparative Example 1

[0080] A medicated bath shampoo for pets and a preparation method thereof. The specific implementation manner is the same as that of Example 1, except that an equal amount of modified chitosan-1 is replaced by chitosan.

[0081] Performance Testing

[0082] The medicated bath shampoos obtained in the above embodiments and comparative examples were subjected to the following tests.

[0083] 1. Microbiological examination

[0084] A total of 200 cats with natural onset of skin disease in a certain area's pet hospital were selected and divided into 10 groups. Samples were collected from the affected areas of the pets and the pathogenic bacteria were counted.

[0085] 2. Test methods

[0086] Calculate the amount of pet medicated bath shampoo required for each cat at a dosage of 2 ml / kg body weight. Apply the pet medicated bath shampoo all over the cat's body and massage, ensuring that the product is in contact with the skin and fur for 10 minutes. Rinse with water. Use twice a week. After 3 weeks of use, collect samples from the same affected area to count the pathogenic bacteria.

[0087] 3. Evaluation Criteria

[0088] Stress behavior evaluation: Observe the cats during bathing to see if they have the following stress behaviors: curling up / motionless, meowing, rapid breathing, wide eyes / dilated pupils, drooling / swallowing saliva, hiding in the corner, ears flat, trembling, struggling / scratching during bathing.

[0089] 0 points: no stressful behavior;

[0090] 3 points: 1-3 stress behaviors;

[0091] 6 points: 4-6 stress behaviors;

[0092] 9 points: 7-9 stress behaviors.

[0093] Evaluation of therapeutic effect: Cured: After taking the medicine, the rate of negative conversion of pathogenic bacteria on the skin is ≥80%; Effective: After taking the medicine, the rate of negative conversion of pathogenic bacteria on the skin is ≥60% and <80%, and at the same time, inflammatory secretions are reduced, the affected area has basically no odor, rashes, dandruff, pustules, etc. are reduced, and the itching symptoms are alleviated; Ineffective: After taking the medicine, the rate of negative conversion of pathogenic bacteria on the skin is <60%; Negative conversion rate % = the number of pathogens that turn negative after taking the medicine on the same affected area / the number of pathogens before taking the medicine × 100%.

[0094] The test results are shown in Table 1.

[0095] Table 1

[0096]

[0097] It can be seen from the data of Examples 1-3 in Table 1 that the medicated bath shampoo of the present invention has a good therapeutic effect and can reduce the stress behavior of pets; from the comparison between Example 4 and Example 1, it can be seen that the change in the ratio of palmitoyl glycine and crotonamine may lead to a decrease in the foaming property of the medicated bath shampoo, which is easy to cause stress behavior of pets and a decrease in the therapeutic effect; from the comparison between Example 5 and Example 1, it can be seen that the change in the ratio of the compound to allyl polyoxyethylene ether enhances the stress response of the pet; from the comparison between Example 6 and Example 1, it can be seen that the change in the ratio of collagen tripeptide to acrylic acid reduces the therapeutic effect; from the comparison between Example 7 and Example 1, it can be seen that the change in the ratio of the modifier to chitosan leads to a decrease in antibacterial property and a decrease in the therapeutic effect; from the comparison between Example 8 and Example 1, it can be seen that it is difficult to rinse directly using ordinary commercially available amino acid surfactants, pets are prone to stress behavior, and the therapeutic effect is reduced; from the comparison between Comparative Example 1 and Example 1, it can be seen that the direct use of chitosan has poor dispersibility in water, is easy to agglomerate, is easy to cause stress behavior of pets, and the therapeutic effect is reduced.

[0098] The above implementation modes are only for illustrating the technical concept and features of the present invention, and their purpose is to enable people familiar with this technology to understand the content of the present invention and implement it, and they cannot be used to limit the protection scope of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the protection scope of the present invention.

Claims

1. A medicated bath shampoo for pets, characterized in that: The invention comprises the following raw materials in parts by weight: 20-25 parts of antimicrobial peptides, 10-20 parts of mite repellent essential oils, 8-13 parts of amino acid surfactants, 6-9 parts of D-panthenol, 6-8 parts of modified chitosan, 0.3-0.6 parts of dodecyl dimethyl betaine, 0.8-1 parts of coconut acid diethanolamide, 0.7-0.9 parts of cocamidopropyl betaine, 0.4-0.6 parts of polyquaternium-39 and 60-70 parts of water.

2. The pet medicated bath shampoo according to claim 1, characterized in that: The antimicrobial peptide is cecropin antimicrobial peptide.

3. The pet medicated bath shampoo according to claim 1, characterized in that: The mite repellent essential oil is a composition of tea tree essential oil, eucalyptus essential oil, lemon essential oil and orange peel essential oil, and the mass ratio of the four is (0.8-1.1):(0.5-0.7):(1-1.2):

1.

4. The pet medicated bath shampoo according to claim 1, characterized in that: The preparation method of the amino acid surfactant comprises the following steps: (1) adding palmitoylglycine, crotylamine and triethylamine to dichloromethane, stirring for 5-10 min, then adding trichloromethyl chloroformate, stirring at room temperature for 30-60 min, extracting, and column chromatography to obtain the compound; (2) Add the compound obtained in step (1), allyl polyoxyethylene ether and azobisisobutyronitrile to anhydrous methanol, stir at 70-80° C. for 1-2 h, filter, wash and dry to obtain an amino acid surfactant.

5. The pet medicated bath shampoo according to claim 4, characterized in that: The mass ratio of palmitoylglycine to crotonamine is 1:(0.2-0.5).

6. The pet medicated bath shampoo according to claim 4, characterized in that: The mass ratio of the compound to the allyl polyoxyethylene ether in the step (2) is 1:(0.5-0.8).

7. The pet medicated bath shampoo according to claim 1, characterized in that: The preparation method of the modified chitosan comprises the following steps: 1) Add collagen tripeptide, acrylic acid and phosphoric acid into DMF, react at 70-80° C. for 5-6 hours, extract, rotary evaporate and dry to obtain a modifier; 2) Add the modifier, chitosan and catalyst obtained in step 1) into anhydrous ethanol, stir at 58-63° C. for 40-60 min, wash, filter and dry to obtain modified chitosan.

8. The pet medicated bath shampoo according to claim 7, characterized in that: The mass ratio of the collagen tripeptide to acrylic acid is 1:(0.7-1).

9. The pet medicated bath shampoo according to claim 7, characterized in that: In the step 2), the mass ratio of the modifier to chitosan is (0.5-0.7):

1.

10. A method for preparing the pet medicated bath shampoo according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1, stirring the mite repellent essential oil, modified chitosan and amino acid surfactant at 40-50° C. for 40-50 min, then adding D-panthenol and antimicrobial peptide and continuing stirring for 20-30 min to obtain a premix; S2. Add dodecyl dimethyl betaine, cocoyl diethanolamide, cocamidopropyl betaine, polyquaternium-39 and water to the premix obtained in step S1, and stir at 40-50° C. for 1-2 hours to obtain a medicated bath shampoo.

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