Traditional Chinese medicine composition for treating psoriasis and preparation method thereof

Abstract

The present invention relates to the technical field of Chinese herbal medicine preparations, and in particular to a Chinese medicine composition for treating psoriasis and a preparation method thereof. The Chinese medicine composition is made of the following raw materials in parts by weight: 38-42 parts of Sophora flavescens, 10-14 parts of Gentiana scabra, 10-14 parts of Cynanchum chinense, 10-14 parts of Schizonepeta tenuifolia, 10-14 parts of Saposhnikovia divaricata, and 10-14 parts of Kochia scoparia. The application of the Chinese medicine composition in the treatment of psoriasis includes the application in oral medicines and the application in external medicines. The dosage form of the pharmaceutical composition is a decoction, and the preparation method of the composition includes the method of taking the raw materials according to the amount, decocting with water, and filtering. The prescription of the present invention is rigorous, concise and orderly, and the various flavors are coordinated and complement each other. It can clear away heat and dampness, dispel wind and relieve exterior symptoms, remove dampness and relieve itching, and promote qi and blood circulation to promote metabolism and shorten the treatment cycle. It has a good therapeutic effect, especially for psoriasis that recurs all year round and is difficult to cure.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese herbal medicine preparations, and in particular to a Chinese medicine composition for treating psoriasis and a preparation method thereof. Background Art

[0002] Psoriasis is a chronic, relapsing inflammatory skin disease with scaly erythema as typical skin lesions. According to the "Global Report on Psoriasis" released by the World Health Organization in 2016, at least 100 million people in the world are affected by psoriasis, and the reported prevalence in various countries ranges from 0.09% to 11.43%. In recent years, the number of psoriasis patients in my country has been increasing year by year.

[0003] Western medicine believes that psoriasis is a multi-gene genetic disease caused by the interaction of genetic factors, immune factors, exogenous and endogenous factors, including infection, trauma, systemic medication, neuropsychiatric factors, etc., which finally cause keratinocytes to proliferate through immune-mediated common pathways. Western medicine treatments for psoriasis include: topical medications such as keratolytics, glucocorticoid preparations, vitamin D3 derivatives such as calcipotriol, and topical retinoids; physical treatments such as psoralen photochemotherapy (PUVA), ultraviolet (UVB) phototherapy, narrow-band ultraviolet (NB-UVB) phototherapy, and 308nm excimer laser phototherapy; systemic drug treatments such as acitretin, methotrexate, cyclosporine, and biological agents such as adalimumab, infliximab, and ustekinumab, and can also be a combination of the above methods. At present, Western medicine has achieved positive results in the treatment of psoriasis, but it also faces some problems, such as easy recurrence, many adverse reactions, and high treatment costs.

[0004] In view of the above-mentioned related technologies, the inventors believe that it is necessary to develop a prescription for treating psoriasis from the perspective of traditional Chinese medicine to make up for the shortcomings of Western medicine and provide a safe and effective new approach for the treatment of psoriasis. Summary of the invention

[0005] In order to improve the problems of easy relapse, many adverse reactions and high treatment costs in current Western medicine psoriasis treatment, the purpose of the present invention is to provide a Chinese medicine composition for treating psoriasis and a treatment method thereof, in order to provide a safe and effective new approach for the treatment of psoriasis.

[0006] In order to achieve the purpose of the present invention, the present invention provides a Chinese medicine composition for treating psoriasis, which adopts the following technical scheme:

[0007] A traditional Chinese medicine composition for treating psoriasis is prepared from the following raw materials in parts by weight: 38-42 parts of sophora flavescens, 10-14 parts of gentiana scabra, 10-14 parts of cynanchum wilfordii, 10-14 parts of schizonepeta tenuifolia, 10-14 parts of siler, and 10-14 parts of kochia scoparia.

[0008] Implementations may include any or all of the following features.

[0009] In one embodiment, the Chinese medicine composition is made of the following raw materials in parts by weight: 40 parts of Sophora flavescens, 12 parts of Gentiana scabra, 12 parts of Cynanchum wilfordii, 12 parts of Schizonepeta tenuifolia, 12 parts of Saposhnikovia divaricata, and 12 parts of Kochia scoparia.

[0010] In the formula of this technical solution, Sophora flavescens tastes bitter, is cold in nature, and enters the heart, liver, stomach, large intestine, and bladder meridians. It is the main drug in this prescription and has the effect of clearing heat and drying dampness. From the perspective of traditional Chinese medicine research on psoriasis, damp-heat accumulation is an important pathological factor of psoriasis. Traditional Chinese medicine theory and clinical practice have proved that Sophora flavescens can directly target damp-heat toxic evil, improve the symptoms of patients' skin erythema, scales, etc. through the effect of clearing heat and drying dampness, and play a major therapeutic role. Gentiana scabra tastes bitter, is cold in nature, enters the liver and gallbladder meridians, has the effect of clearing heat and drying dampness, and purging liver and gallbladder fire, and is the minister drug in this prescription. It can assist Sophora flavescens to strengthen the effects of clearing heat, drying dampness, and detoxification, especially for the psoriasis symptoms caused by liver and gallbladder damp-heat, it can play a synergistic therapeutic role, help eliminate heat toxins, and alleviate skin inflammation. Xu Changqing tastes pungent and warm in nature. It enters the liver and stomach meridians. It has the effects of dispelling wind and dampness, promoting qi and blood circulation, relieving pain and relieving itching. It can improve the circulation of qi and blood in patients, dispel wind, remove dampness and relieve itching, assist the main medicine and another minister medicine, Gentiana scabra, and promote the circulation of qi and blood in patients, thereby promoting metabolism and promoting the efficacy of the main and minister medicines, and plays a major therapeutic role in the complications of psoriasis.

[0011] This prescription also uses Schizonepeta, Saposhnikovia and Kochia scoparia as adjuvants. Schizonepeta is pungent and slightly bitter, warm in nature, and enters the lung and liver meridians. It has the effect of dispelling wind and dispersing the exterior. In the prescription, it assists with Cynanchum chinense to enhance the power of dispelling wind. Saposhnikovia is pungent and sweet, slightly warm in nature, and enters the bladder, liver, and spleen meridians. It has the effects of dispelling wind and dispelling exterior, eliminating dampness and relieving pain, and stopping spasms. It cooperates with Schizonepeta to assist in dispelling wind. At the same time, Schizonepeta and Saposhnikovia complement the properties of the monarch and ministerial drugs to prevent the monarch and ministerial drugs from being too cold and causing cold stagnation. Kochia scoparia as an adjuvant enhances the prescription's effect of clearing heat and promoting dampness, and at the same time assists in dispelling wind and relieving itching.

[0012] The medicines used in this prescription have been screened based on traditional Chinese medicine theory and decades of clinical application practice. The prescription only uses 6 Chinese medicines, the formula is concise and the priorities are orderly, they cooperate and complement each other, and have unique compatibility advantages. It has a good therapeutic effect on psoriasis, which recurs throughout the year and is difficult to cure. Patients are basically cured after taking the medicine and there is no relapse.

[0013] The present invention also provides an application of the above-mentioned Chinese medicinal composition for treating psoriasis in preparing a medicine for treating psoriasis.

[0014] In one embodiment, the use includes use in an internal medicine for treating psoriasis, or use in an external medicine for treating psoriasis.

[0015] In one embodiment, the drug is in the form of a decoction.

[0016] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition for treating psoriasis, comprising the steps of taking raw medicine according to amount, boiling with water and filtering.

[0017] In summary, the present invention provides a Chinese medicine composition for treating psoriasis and a preparation method thereof, which has the following beneficial effects:

[0018] First, the prescription is rigorous and concise. There are 6 Chinese medicinal herbs in the whole prescription. The medicinal properties of each medicine both cooperate and complement each other. It is screened through long-term clinical practice. It has a good therapeutic effect on psoriasis, which recurs throughout the year and is difficult to cure. Patients are basically cured after taking the medicine and there is no relapse.

[0019] Second, the preparation process of this prescription adopts traditional water decoction extraction, the preparation method is simple, can be operated at home, has low economic cost, and is suitable for promotion and use in various regions across the country. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a flow chart of the method for preparing the Chinese medicine composition for treating psoriasis in Example 2.

[0021] Figure 2A The disease condition of the patient's head skin before using the Chinese medicine composition of this application.

[0022] Figure 2B This is the recovery condition of the patient's head skin after using the Chinese medicine composition of this application for a period of time.

[0023] Figure 3A The disease condition of the skin on the side of the patient's body before using the Chinese medicine composition of this application.

[0024] Figure 3B The disease condition of the skin on the back of a patient's body before using the Chinese medicine composition of this application.

[0025] Figure 3C This is the recovery condition of the skin on the side of the patient's body after using the Chinese medicine composition of this application for a period of time.

[0026] Figure 3D This is the recovery condition of the skin on the back of the patient's body after using the Chinese medicine composition of this application for a period of time. DETAILED DESCRIPTION

[0027] The following will further illustrate the embodiments of the present invention in conjunction with the accompanying drawings and specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. It should be noted that many specific details are set forth in the following description to facilitate a full understanding of the present invention, but the present invention can also be implemented in other ways different from those described herein, and therefore, the protection scope of the present invention is not limited by the specific embodiments disclosed below. If specific conditions are not specified in the embodiments, they are carried out according to normal conditions or conditions recommended by the manufacturer. If the manufacturer is not specified in the reagents or instruments used, they are all conventional products that can be purchased commercially.

[0028] Example 1

[0029] The present embodiment discloses a traditional Chinese medicine composition for treating psoriasis and its application, which is prepared from the following raw materials in parts by weight: 40 parts of Sophora flavescens, 12 parts of Gentiana scabra, 12 parts of Cynanchum paniculatum, 12 parts of Schizonepeta tenuifolia, 12 parts of Saposhnikovia divaricata, and 12 parts of Kochia scoparia, specifically, 200g of Sophora flavescens, 60g of Gentiana scabra, 60g of Cynanchum paniculatum, 60g of Schizonepeta tenuifolia, 60g of Saposhnikovia divaricata, and 60g of Kochia scoparia.

[0030] This embodiment also discloses a use of the above-mentioned Chinese medicine composition in the preparation of a drug for treating psoriasis. The above-mentioned prescription can be directly used to treat psoriasis. Specifically, the medicine in the above-mentioned prescription can be boiled into a decoction, which can be taken orally or applied externally to the affected area. In some other embodiments, other adjuvants other than this prescription can also be used together for the treatment of psoriasis. The adjuvant can be a Chinese herbal medicine that can play a dual-treatment role, or it can be an auxiliary molding agent that can assist the prescription in forming other dosage forms such as tablets, pills, plasters, etc., for internal or external use in the treatment of psoriasis.

[0031] Example 2

[0032] Reference Figure 1 This embodiment discloses a method for preparing the above-mentioned Chinese medicine composition for treating psoriasis, comprising taking the raw material medicine according to the amount, decocting with water, and filtering, specifically:

[0033] S1, grab each raw material drug according to the formula of Example 1;

[0034] S2, all the raw materials are boiled in water at least twice, the first time water is added to 10 times the amount of all the raw materials, boiled for 2 hours, and the decoction is taken, the second time and other multiple times water is added to 8 times the amount of all the raw materials, boiled for 1 hour, and the decoction is taken;

[0035] S3, combine all the decoctions, filter and store.

[0036] The decoction prepared according to the above preparation method can be taken orally as a therapeutic decoction or applied externally to the affected area.

[0037] Referring to FIG. 2, Figure 2A The condition of the patient's head skin before using the Chinese medicine composition of this application, Figure 2B After taking the Chinese medicine composition of the present application for 14 times, the patient's head skin recovered and his head skin basically returned to its original state. The patient's subsequent condition was stable without recurrence.

[0038] Referring to FIG. 3 , Figure 3A , 3B The disease condition of the patient's skin before using the Chinese medicine composition of this application, Figure 3C , 3D After taking the Chinese medicine composition of the present application for 26 times, the patient's skin recovered and his skin basically returned to its original state. The patient's subsequent condition was stable without recurrence.

[0039] The above patients are all patients with long-term illness, long-term incurable disease, and recurrent condition. The use of the Chinese medicine composition of the present application has a short treatment time, fast effect, no toxic side effects, and the condition is stable after recovery without recurrence.

[0040] The Chinese medicine decoction prepared according to the Chinese medicine composition for treating psoriasis and the preparation method thereof is mainly suitable for the treatment of psoriasis, and can also be used for the treatment of other fungal or allergic skin diseases such as eczema, scabies, urticaria, etc.

[0041] Of course, the above embodiments are the best embodiments of the present invention, which are only used to illustrate the technical concept and features of the present invention, and their purpose is to enable people familiar with this technology to understand the content of the present invention and implement it accordingly, and they cannot be used to limit the protection scope of the present invention. Any modifications made according to the spirit of the main technical solution of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating psoriasis, characterized in that: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 38-42 parts of Sophora flavescens, 10-14 parts of Gentiana scabra, 10-14 parts of Cynanchum wilfordii, 10-14 parts of Schizonepeta tenuifolia, 10-14 parts of Saposhnikovia divaricata, and 10-14 parts of Kochia scoparia.

2. A Chinese medicine composition for treating psoriasis according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following raw materials in parts by weight: 40 parts of Sophora flavescens, 12 parts of Gentiana scabra, 12 parts of Cynanchum wilfordii, 12 parts of Schizonepeta tenuifolia, 12 parts of Saposhnikovia divaricata, and 12 parts of Kochia scoparia.

3. Use of a Chinese medicine composition for treating psoriasis as claimed in any one of claims 1 to 2 in the preparation of a medicament for treating psoriasis.

4. The use according to claim 3, characterized in that The application includes application in internal medicine for treating psoriasis, or application in external medicine for treating psoriasis.

5. The use according to claim 4, characterized in that The dosage form of the medicine is decoction.

6. A method for preparing a Chinese medicine composition for treating psoriasis according to any one of claims 1 to 2, characterized in that: The method includes measuring the raw material medicine, boiling it with water and filtering it.

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