Colorant, preparation method and alcohol-based disinfectant coating device
By adding dye to the alcohol-based disinfectant and using carrier technology to develop color, the problem that the alcohol-based disinfectant is colorless makes it difficult for medical staff to identify the disinfected areas, achieving clear labeling and smooth operation.
Patent Information
- Application Number
- CN202411726746.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-28
- Publication Date
- 2025-04-04
AI Technical Summary
The alcohol-based disinfectant solution itself is colorless, making it difficult for medical staff to identify areas that have been disinfected, affecting the operation.
Using a preparation method of a colorant, by mixing the dye with an alcohol-based disinfectant, adsorbing and releasing the dye with a carrier to form a color-developable disinfectant, thereby identifying the disinfected area.
It has achieved clear identification in the disinfected areas, improved the ability of medical staff to identify the disinfected areas, and ensured the smooth progress of the surgery.
Smart Images
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of medicines and antibacterial products, and in particular to a colorant, a preparation method and an alcohol-based disinfectant coating device. Background Art
[0002] Alcohol-based disinfectants are disinfectants with ethanol and isopropanol as the main ingredients, and have the advantages of broad-spectrum antibacterial properties and fast volatilization. Iodine-based disinfectants are disinfectants with povidone-iodine, a complex of iodine and povidone, as the main ingredient. They have low skin irritation and are suitable for disinfection of wounds and burns, but those who are allergic to iodine should not use them.
[0003] Alcohol-based disinfectant applicator, also known as preoperative skin preparation, is a kind of disinfectant solution used on the surgical skin surface. This product uses a disinfectant solution of CHG (chlorhexidine gluconate) plus ethanol or isopropyl alcohol to replace iodine and other disinfectant solutions. This disinfectant not only has a better sterilization effect but also can form a film on the skin surface, achieving long-lasting and broad-spectrum antibacterial activity. Its drying time on the hairless skin surface is only 30s. Therefore, this disinfectant has been recommended by many medical organizations such as WHO, ACS / SIS, and CDC.
[0004] Since the alcohol-based disinfectant solution itself is colorless and the traces left after the solution dries are not obvious, it is difficult for medical staff to identify the areas that have been disinfected, which in turn affects the progress of the operation. Summary of the invention
[0005] The object of the present invention is to provide a colorant capable of marking a disinfected area; another object of the present invention is to provide a method for preparing a colorant capable of marking a disinfected area; another object of the present invention is to provide an alcohol-based disinfectant coating device capable of clearly identifying a disinfected area.
[0006] The present invention discloses a method for preparing a colorant, comprising the following steps:
[0007] S1: prepare a solvent and adjust the pH of the solution to 5-9 using a pH adjuster;
[0008] S2: uniformly mixing the dye with the liquid obtained in step S1 to obtain a colored liquid;
[0009] S3: After the carrier is fully contacted with the coloring liquid, the carrier is dried and sterilized to obtain a colorant.
[0010] The pH of the solution is adjusted to 5-9 using a pH regulator, which is beneficial to increasing the solubility of the dye in the solvent and will not affect the effect of the slightly acidic alcohol-based disinfectant.
[0011] The purpose of the solvent is to dissolve the dye, and it can be methanol, ethanol, isopropanol, water, etc.
[0012] Furthermore, in step S1, the solvent includes one or both of water and ethanol; and the pH adjuster includes hydrochloric acid or sodium hydroxide.
[0013] The solvents selected are water and / or ethanol, which are economical, environmentally friendly and easy to operate; the reasons for selecting hydrochloric acid or sodium hydroxide as pH adjusters are that the pH value can be quickly and accurately controlled, the chemical properties are stable and not easy to decompose, and the cost is low.
[0014] Furthermore, in step S2, the dye is selected from one or more of Fast Green FCF, Sunset Yellow, Lemon Yellow, Fruit Green, Methyl Green, Chlorophyll, Brilliant Blue, Brilliant Green SF, Bromophenol Green, Alizarin Green F, Curcumin, and Gardenia Blue.
[0015] These dyes are non-toxic and harmless, have high chemical stability, are not prone to decomposition or deterioration, have good light resistance, are suitable for use in situations where they need to be exposed to light for a long time, and have good solubility.
[0016] Preferably, the dye is selected from one or a combination of brilliant blue, alizarin green F, curcumin, gardenia blue.
[0017] Brilliant Blue, Alizarin Green F, Curcumin, and Gardenia Blue have good skin coloring ability.
[0018] Furthermore, in step S2, the coloring liquid also includes a thickener.
[0019] A thickener is added to the coloring liquid to increase the viscosity of the alcohol-based disinfectant flowing through it, thereby preventing the alcohol-based disinfectant from flowing freely on the skin surface during use.
[0020] Furthermore, in step S2, the raw materials of the coloring liquid include, by weight:
[0021] 50-100 parts of solvent;
[0022] Dye 0.08-0.8 parts;
[0023] Thickener 0.02-0.08 parts.
[0024] Furthermore, the thickener is sodium chloride.
[0025] Further, the concentration of the dye in the coloring liquid is 0.4-18 g / L. More preferably, the concentration of the dye is 0.8-8 g / L. When the concentration of the dye is controlled within this range, the dye can develop color well in the alcohol-based disinfectant and will not seriously cover the surface of the skin.
[0026] Low concentrations of sodium chloride can increase the viscosity of the solution, making it easier for the disinfectant to adhere to the surface of the skin; and sodium chloride has stable chemical properties and will not react chemically with other ingredients in the coloring liquid.
[0027] Furthermore, in step S3, the carrier is a porous structure, such as dyed cotton or multi-layer non-woven fabric.
[0028] The function of the carrier is to adsorb the dye and release the dye when the alcohol-based dye solution flows through the carrier.
[0029] Furthermore, the material of the carrier includes one or both of polyurethane and polyester fiber.
[0030] The dye has strong adhesion to the polyurethane and / or polyester fibers through hydrogen bonds and electrostatic interactions. Meanwhile, the polyurethane and / or polyester fibers have no capillary effect on the dye. When the alcohol-based disinfectant flows through the colorant, the dye will quickly dissolve in the alcohol-based disinfectant.
[0031] The present invention also discloses a colorant, obtained by the preparation method as described above, wherein the mass ratio of the colorant to the carrier is 0.25-25wt%. More preferably, the mass ratio of the colorant to the carrier is 0.5-12.5wt%. More preferably, the mass ratio of the colorant to the carrier is 1-6.25wt%.
[0032] The present invention also discloses an alcohol-based disinfectant coating device, comprising the colorant and alcohol-based disinfectant as described above; when stored, the colorant and the alcohol-based disinfectant are separated and placed without contact by a barrier or respective independent cavities; when used, the barrier is removed or the separately placed cavities are connected, and the alcohol-based disinfectant flows through the colorant to take away the colorant.
[0033] During storage, the colorant and the alcohol-based disinfectant can be stored in a cavity separated by a barrier in the same container; or the colorant and the alcohol-based disinfectant can be stored in two containers with cavities. When in use, the barrier is removed or the cavities of the two containers are connected, and the alcohol-based disinfectant will flow into the colorant to dissolve the colorant and take it away, and a clear mark will be formed in the disinfected area as the alcohol-based disinfectant is used.
[0034] When used simultaneously, the alcohol-based disinfectant needs to flow through the colorant, and the time for the disinfectant solution to reach the sponge is controlled, so that preparation time for the operation can be reserved to avoid misoperation.
[0035] Storing alcohol-based disinfectants and colorants separately avoids adding colorants directly to alcohol-based disinfectants, which greatly reduces the production and storage requirements of alcohol-based disinfectants. The production links are independent of each other, which facilitates the unified production of disinfectants of different specifications and models, and reduces the risks in the production, storage and transportation links.
[0036] The invention discloses a colorant, which is fixed in a carrier and will not move randomly to affect the final coloring effect. When an alcohol-based disinfectant flows through the colorant, the colorant can be quickly taken away, and a clear marking effect is displayed with the use of the alcohol-based disinfectant. BRIEF DESCRIPTION OF THE DRAWINGS
[0037] Figure 1 This is a picture of the colorant prepared in Example 2 of the present invention before drying;
[0038] Figure 2 This is a picture of the colorant prepared in Example 2 of the present invention after drying;
[0039] Figure 3 This is a color picture of the alcohol-based disinfectant application device assembled with the colorant prepared in Example 2 of the present invention after applying it to the skin of the leg;
[0040] Figure 4 This is a color development picture after the alcohol-based disinfectant application device assembled with the colorant prepared in Example 2 of the present invention is applied to the skin of the arm. DETAILED DESCRIPTION
[0041] In order to make the technical solution of the present invention clearer, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.
[0042] Example 1
[0043] The coloring liquid of this embodiment uses brilliant blue as a dye and polyester fiber as the material of the dyed cotton. The preparation method is as follows:
[0044] 1. Add 1 mol / L hydrochloric acid to 100 mL of a mixed solution of ethanol and water (the volume ratio of ethanol to water is 1:1) to adjust the pH of the mixed solution to 5.
[0045] 2. Add 0.8g of brilliant blue and 0.05g of sodium chloride to the ethanol-water mixture and stir until completely dissolved to obtain a colored solution.
[0046] 3. Place the dyed cotton made of polyester fiber in the coloring liquid and squeeze it to absorb the liquid until it is saturated. Transfer the dyed cotton to an oven and dry it at 80°C for 8 hours. After sterilization, the final product is obtained.
[0047] The mass of the colorant after drying is 0.45±0.05 g, of which the content of the dye is 20 mg.
[0048] Example 2
[0049] The coloring liquid of this embodiment uses Alizarin Green F as a dye and polyurethane as a material for dyeing cotton, and the preparation method is as follows:
[0050] 1. Add 1 mol / L sodium hydroxide aqueous solution to 100 mL of purified water to adjust the pH of the purified water to 9.
[0051] 2. Add 0.8 g of Alizarin Green F and 0.05 g of sodium chloride to purified water and stir until dissolved to obtain a colored solution.
[0052] 3. Place the polyurethane dyed cotton in the coloring liquid and squeeze it to absorb the liquid until it is saturated (the dyed cotton obtained is as follows Figure 1 The dyed cotton was transferred to an oven at 60°C and dried for 4 h (the colorant obtained was as shown in Figure 2 After sterilization, the colorant is obtained.
[0053] The mass of the colorant after drying is 0.45±0.05 g, of which the content of the dye is 20 mg.
[0054] Example 3
[0055] Curcumin and gardenia blue are used as dyes, and polyurethane multilayer non-woven fabric is used as a carrier. The preparation method is as follows:
[0056] 1. Add 1 mol / L hydrochloric acid to 100 mL of purified water to adjust the pH of the purified water to 6.
[0057] 2. Add 0.4 g of curcumin, 0.4 g of gardenia blue and 0.05 g of sodium chloride to purified water and stir until dissolved to obtain a colorant solution.
[0058] 3. Place a multi-layer non-woven fabric made of polyurethane in the coloring liquid and squeeze it to absorb the liquid until it is saturated. Transfer the multi-layer non-woven fabric to an oven at 60°C, dry it for 4 hours, and obtain the colorant after sterilization.
[0059] The mass of the colorant after drying is 0.45±0.05 g, of which the content of the dye is 20 mg.
[0060] Example 4
[0061] Using solid green FCF as a dye and polyurethane as a carrier, the preparation method is as follows:
[0062] 1. Add 1 mol / L sodium hydroxide to 100 mL of purified water to adjust the pH of the purified water to 8.
[0063] 2. Add 0.4g Fast Green SF and 0.05g sodium chloride to purified water and stir until dissolved to obtain a colorant solution.
[0064] 3. Place the polyurethane dyed cotton in the coloring liquid and squeeze it to absorb the liquid until saturated. Transfer the polyurethane to an oven at 60°C, dry for 4 hours, and obtain the colorant after sterilization.
[0065] The mass of the colorant after drying is 0.45±0.05 g, of which the content of the dye is 10 mg.
[0066] Example 5
[0067] Sunset yellow is used as a dye and polyester fiber is used as a carrier. The preparation method is as follows:
[0068] 1. Add 1 mol / L hydrochloric acid to 100 mL of purified water to adjust the pH of the purified water to 5.
[0069] 2. Add 0.8g Fast Green SF and 0.05g sodium chloride to purified water and stir until dissolved to obtain a colorant solution.
[0070] 3. Place the dyed cotton made of polyester fiber in the coloring liquid and squeeze it to absorb the liquid until it is saturated. Transfer the polyester fiber to an oven at 60°C, dry it for 4 hours, and obtain the colorant after sterilization.
[0071] The mass of the colorant after drying is 0.45±0.05 g, of which the content of the dye is 20 mg.
[0072] Assemble into alcohol-based disinfectant applicator:
[0073] The alcohol-based disinfectant smearing device comprises 4 parts, namely a container containing disinfectant, a colorant, a smear sponge for smearing, and a shell that fixes the three. The container containing disinfectant is provided with an excitation device, which can open the container. The colorant is installed directly below the container containing disinfectant. When the excitation device opens the container to release the disinfectant, the liquid will first pass through the colorant and take away the colorant contained therein, and then flow into the smear sponge, waiting for smearing. According to the content of the colorant, the specifications of the colorant include 30mg, 20mg, 10mg, 5mg, 3mg and 1mg; the colorant can be used in conjunction with the disinfectant of the corresponding specifications. In Examples 1-5, a colorant of 20mg is used in conjunction with 10mL of alcohol-based disinfectant, a colorant of 30mg is used in conjunction with 26mL of alcohol-based disinfectant, and a colorant of 10mg is used in conjunction with 6mL of alcohol-based disinfectant.
[0074] Performance Testing:
[0075] The colorants prepared in Examples 1-5 were assembled into an alcohol-based disinfectant application device and the pure alcohol-based disinfectant of the comparative example was applied to the skin of the arms and legs. The color change of the skin surface after applying the disinfectant was measured using a colorimeter. The results are shown in Table 1.
[0076] Table 1 Color difference test results
[0077]
[0078] As shown in Table 1, the color difference of Examples 1-5 after being applied on the skin of the arms and legs is greater than 3, and a color difference greater than 3 can be observed by the naked eye. Therefore, compared with pure alcohol-based disinfectants, the use of colorants before application can make the applied area easier to be identified by the naked eye.
[0079] An alcohol-based disinfectant coating device with a colorant installed and an alcohol-based disinfectant coating device without a colorant installed were tested to determine the time it takes for the alcohol-based disinfectant to reach the coating sponge during use. The results are shown in Table 2.
[0080] Table 2 Alcohol-based disinfectant arrival time test results of the smear sponge
[0081]
[0082]
[0083] As shown in Table 2, the time it takes for the alcohol-based disinfectant with colorant to reach the sponge is 10 seconds, and the time it takes for the alcohol-based disinfectant without colorant to reach the sponge is 3 seconds. It can be seen that installing the colorant does not affect the application of the disinfectant. At the same time, a slight delay of 7 seconds for the conductive sponge can give the user time to prepare for the operation to avoid misoperation.
[0084] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.
Claims
1. A method for preparing a colorant, characterized in that: The following steps are involved: S1: prepare a solvent and adjust the pH of the solution to 5-9 using a pH adjuster; S2: uniformly mixing the dye with the liquid obtained in step S1 to obtain a colored liquid; S3: After the carrier is fully contacted with the coloring liquid, the carrier is dried and sterilized to obtain a colorant.
2. The method for preparing a colorant according to claim 1, characterized in that: In the step S1, the solvent includes one or both of water and ethanol; and the pH adjuster includes hydrochloric acid or sodium hydroxide.
3. The method for preparing a colorant according to claim 1, characterized in that: In step S2, the dye is selected from one or more of Fast Green FCF, Sunset Yellow, Lemon Yellow, Fruit Green, Methyl Green, Chlorophyll, Brilliant Blue, Brilliant Green SF, Bromophenol Green, Alizarin Green F, Curcumin, and Gardenia Blue.
4. The method for preparing a colorant according to claim 3, characterized in that: In the step S2, the coloring liquid further includes a thickener.
5. The method for preparing a colorant according to claim 4, characterized in that: In step S2, the raw materials of the coloring liquid include, by weight: 50-100 parts of solvent; Dye 0.08-0.8 parts; Thickener 0.02-0.08 parts.
6. The method for preparing a colorant according to claim 5, characterized in that: The thickener is sodium chloride.
7. The method for preparing a colorant according to claim 1, characterized in that: In step S3, the carrier is a porous structure, such as dyed cotton or multi-layer non-woven fabric.
8. The method for preparing a colorant according to claim 7, characterized in that: The material of the carrier includes one or both of polyurethane and polyester fiber.
9. A colorant, characterized in that The method is used as claimed in any one of claims 1 to 8, wherein the mass ratio of the dye to the carrier is 0.25-25wt%.
10. An alcohol-based disinfectant application device, characterized in that: It comprises the colorant as claimed in claim 9 and an alcohol-based disinfectant; when stored, the colorant and the alcohol-based disinfectant are separated and placed without contact by a barrier or respective independent cavities; when used, the barrier is removed or the separately placed cavities are connected, and the alcohol-based disinfectant flows through the colorant to carry away the colorant.