Equipment and process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets

Abstract

The invention discloses equipment and process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets. The equipment and process comprise a substrate, a plunger pump is fixedly connected to the substrate, a first cylinder body is fixedly connected to the plunger pump, a first piston is slidably connected in the first cylinder body, the first piston is fixedly connected to the output end of the plunger pump, and a homogenizing component is arranged on the top of the first piston; the process comprises: step one, preparation work; step two, raw material input; step three, circulation homogenization; step four, raw material output; the homogenizing component of the invention uses a rotating second blade to clean the gap between the concentric annular groove and the concentric annular body, thereby preventing the problem of blockage and improving the homogenizing effect; two cylinder bodies are connected by a four-way pipe, and the raw material is pushed back and forth in the two cylinder bodies by a piston, so that the plunger pump can make the material pass through the homogenizing component twice in a round trip, thereby improving the homogenizing efficiency; the plunger pump is used to provide power for the circulation of the coolant, thereby reducing the cost of the equipment.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical production, and in particular to equipment and a process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets. Background Art

[0002] Thiamphenicol Enteric-coated Tablets are an antibiotic drug, the main ingredient of which is thiamphenicol. Its mechanism of action is to inhibit the synthesis of bacterial proteins by binding to the 50S subunit of the bacterial ribosome, thereby exerting an antibacterial effect. This binding interferes with the activity of peptidyl transferase, prevents the extension of the peptide chain, and prevents bacteria from synthesizing the proteins they need normally, ultimately leading to the inhibition of bacterial growth and reproduction. In the preparation process of thiamphenicol enteric-coated tablets, the existing technology generally uses a homogenizer to homogenize the material to improve the stability and bioavailability of thiamphenicol enteric-coated tablets. The plunger homogenizer mainly achieves the homogenization of the material through the reciprocating motion of the plunger. Its core components include the plunger, pump body, homogenizer and material cylinder. When the plunger moves away from the homogenizer, a low-pressure area is formed inside the pump body. Since the external pressure is higher than the pressure inside the pump body, the material is sucked into the material cylinder of the pump body through the feed port under the action of the pressure difference. Then, the plunger moves toward the homogenizer, squeezing the material in the pump body and increasing the pressure. When the pressure reaches a certain level, the material is squeezed out through the homogenizer. In this process, the material will be subjected to multiple forces, thereby achieving homogenization. However, this type of homogenizer has the following disadvantages when in use: 1. During the operation of the homogenizer, the temperature of the material will gradually rise, so it is necessary to use coolant to circulate and cool it, but the existing circulating cooling device needs to rely on an additional power source to drive, resulting in increased equipment costs; 2. The existing homogenizer is prone to clogging problems after being used for a long time, affecting the normal operation of the homogenizer and reducing the homogenization efficiency; 3. In order to achieve circulating homogenization, it is necessary to add a pipeline to lead the homogenized material back to the vicinity of the feed port, which makes the pipeline complicated, and one reciprocating action of the plunger pump can only make the material pass through the homogenizer once, so the efficiency is relatively low. Summary of the invention

[0003] The object of the present invention is to provide equipment and process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets, so as to solve the problems raised in the above-mentioned background technology.

[0004] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: an apparatus for improving the stability and bioavailability of thiamphenicol enteric-coated tablets, comprising a substrate, a plunger pump is fixedly connected to the substrate, a first cylinder is fixedly connected to the plunger pump, a first piston is slidably connected in the first cylinder, and the first piston is fixedly connected to the output end of the plunger pump, a homogenizing component is arranged on the top of the first piston, the homogenizing component comprises a bracket, and the bracket is fixedly connected to the first cylinder, a connecting shaft is rotatably connected to the bracket, a plurality of first blades are evenly distributed on one end of the connecting shaft, two second shells are fixedly connected to the connecting shaft, and the second shells are respectively arranged on both sides of the bracket, a concentric annular groove is opened on the second shell, a concentric ring body is arranged in the concentric annular groove, and the concentric ring body is fixedly connected to the bracket.

[0005] Preferably, a plurality of second blades are evenly distributed on both sides of the concentric annular body, and the second blades are fixedly connected in the concentric annular grooves.

[0006] Preferably, a plurality of through holes are evenly distributed in the concentric annular groove, and one end of the through hole is conductively connected to a truncated cone groove.

[0007] Preferably, a first shell is fixed on the upper surface of the first cylinder body, and the first blade is arranged in the first shell. A first connecting pipe is fixed in the tangential direction of the first shell, and a four-way pipe is fixed at the other end of the first connecting pipe, and the other three ports of the four-way pipe are all fixed with electric valves.

[0008] Preferably, a second cylinder body is provided on one side of the plunger pump, a third cylinder body is connected and fixed on the upper surface of the second cylinder body, a third piston is slidably connected in the third cylinder body, a third shell is connected and fixed on the upper surface of the third cylinder body, a second connecting pipe is connected and fixed on the third shell, and the other end of the second connecting pipe is connected and fixed on one of the electric valves.

[0009] Preferably, a connecting rod is fixedly connected to the lower surface of the third piston, the other end of the connecting rod is fixedly connected to the second piston, and the second piston is slidably connected in the second cylinder body. Two one-way valves are fixedly connected to the lower surface of the second cylinder body, wherein the input end of one of the one-way valves is fixedly connected to the second liquid inlet pipe, and the output end of the other one-way valve is fixedly connected to the third connecting pipe.

[0010] Preferably, a jacket is fixedly connected to the third cylinder body, a spiral baffle is fixedly connected inside the jacket, and the spiral baffle is fixedly connected to the third cylinder body, a liquid outlet pipe is fixedly connected to an outer wall on one side of the jacket, a first liquid inlet pipe is fixedly connected to an outer wall on the other side of the jacket, and the input end of the first liquid inlet pipe is fixedly connected to the output end of the third connecting pipe.

[0011] The process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets comprises step one, preparation; step two, raw material input; step three, circulating homogenization; and step four, raw material output;

[0012] In the above step 1, the two electric valves are connected to the raw material input pipe and the output pipe respectively, the second liquid inlet pipe is connected to the output end of the coolant storage tank, the liquid outlet pipe is connected to the input end of the coolant radiator, the output end of the coolant radiator is connected to the input end of the coolant storage tank, the first piston is adjusted to the top of the first cylinder as the initial state, and the third piston is adjusted to the top of the third cylinder as the initial state;

[0013] In the above step 2, the electric valve connected to the raw material input pipe is opened, the other electric valves are closed, the plunger pump is retracted, the raw material input pipe is fed, and after the raw material input is completed, the raw material input pipe stops feeding, and the electric valve connected to the raw material input pipe is closed;

[0014] In the above step 3, the electric valve connected to the second connecting pipe is opened, the other electric valves are closed, and the plunger pump is started to drive the first piston to perform reciprocating linear motion, so that the raw material continuously passes through the homogenizing component for homogenization;

[0015] In the above step 4, after the homogenization process in step 3 is completed and the first piston is in the initial state, the electric valve connected to the raw material output pipe is opened, and the remaining electric valves are closed. The plunger pump extends to drive the first piston to move upward, and the homogenized raw material is discharged into the raw material output pipe through the four-way pipe. Then, the electric valve connected to the raw material input pipe is opened, and the remaining electric valves are closed, and the next raw material input action can be carried out.

[0016] Preferably, in step three, when the first piston moves downward, the raw material will enter the first shell along the tangential direction, thereby driving the first blade, causing the connecting shaft to rotate, and the second shell on the connecting shaft will rotate accordingly, and the second blade in the second shell will move accordingly, thereby cleaning the gap between the concentric annular groove and the concentric annular body to prevent blockage.

[0017] Preferably, in step three, when the first piston makes reciprocating linear motion, the third piston will move up and down, and the third piston will drive the second piston through the connecting rod. The second piston will suck the coolant in the coolant storage tank into the second cylinder body, and then discharge the coolant in the second cylinder body into the jacket. The coolant in the jacket is discharged into the coolant radiator through the liquid outlet pipe to realize the circulation of the coolant.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows: the homogenizing component of the present invention utilizes the rotating second blade to clean the gap between the concentric annular groove and the concentric annular body, thereby preventing blockage problems and improving the homogenizing effect; the two cylinder bodies are connected by a four-way pipe, and the piston is utilized to push the raw material back and forth in the two cylinder bodies, so that the plunger pump can make the material pass through the homogenizing component twice in one round trip, thereby improving the homogenizing efficiency; the plunger pump is utilized to provide power for the circulation of the coolant, thereby reducing the cost of the equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the overall three-dimensional structure of the present invention;

[0020] Figure 2 It is a schematic diagram of the overall three-dimensional cutaway structure of the present invention;

[0021] Figure 3 It is a schematic diagram of the three-dimensional structure of the homogenizing component of the present invention;

[0022] Figure 4 It is an exploded view of the three-dimensional structure of the homogeneous component of the present invention;

[0023] Figure 5 It is a schematic diagram of a partial three-dimensional cutaway structure of a homogenizing component of the present invention;

[0024] Figure 6 It is a process flow chart of the present invention.

[0025] In the figure: 1, substrate; 11, plunger pump; 12, first cylinder; 13, first piston; 14, first shell; 15, first connecting pipe; 2, homogenizing assembly; 21, bracket; 22, connecting shaft; 23, first blade; 24, second shell; 25, concentric annular groove; 26, second blade; 27, through hole; 28, truncated cone groove; 29, concentric annular body; 3, four-way pipe; 4, electric valve; 5, second cylinder; 51, second piston; 52, connecting rod; 53, third piston; 54, third cylinder; 55, third shell; 56, second connecting pipe; 57, jacket; 58, spiral baffle; 59, liquid outlet pipe; 510, first liquid inlet pipe; 511, one-way valve; 512, third connecting pipe; 513, second liquid inlet pipe. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Please refer to the attached Figure 1 -Attached Figure 5An embodiment of the present invention provides a device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets, comprising a substrate 1, a plunger pump 11 is fixedly connected to the substrate 1, a first cylinder 12 is fixedly connected to the plunger pump 11, a first piston 13 is slidably connected in the first cylinder 12, and the first piston 13 is fixedly connected to the output end of the plunger pump 11, a homogenizing component 2 is arranged on the top of the first piston 13, the homogenizing component 2 comprises a bracket 21, and the bracket 21 is fixedly connected to the first cylinder 12, a connecting shaft 22 is rotatably connected to the bracket 21, a plurality of first blades 23 are evenly distributed on one end of the connecting shaft 22, two second shells 24 are fixedly connected to the connecting shaft 22, and the second shells 24 are respectively provided with The second housing 24 is provided with a concentric annular groove 25, and a concentric annular body 29 is arranged in the concentric annular groove 25, and the concentric annular body 29 is fixedly connected to the housing 21. The plunger pump 11 is used to drive the first piston 13. The first piston 13 performs reciprocating linear motion in the first cylinder 12 to drive the material to pass through the homogenizing component 2. The homogenizing component 2 uses the two second housings 24 as rotating parts and the housing 21 as a fixed part. The gap between the concentric annular groove 25 and the concentric annular body 29 is used as a material crushing place. The first blade 23 is used to drive the second housing 24 through the connecting shaft 22; a plurality of second blades 26 are evenly distributed on both sides of the concentric annular body 29, and the second blades 26 are fixedly connected to the concentric annular body 29. In the annular groove 25, the gap between the concentric annular groove 25 and the concentric annular body 29 is cleaned by the rotating second blade 26; a plurality of through holes 27 are evenly distributed in the concentric annular groove 25, one end of the through hole 27 is connected to the truncated cone groove 28, and the through hole 27 and the truncated cone groove 28 are used for the entry and exit of materials. By arranging the through holes 27 on the two second shells 24, the bidirectional flowing materials can be homogenized; the upper surface of the first cylinder body 12 is connected to the first shell 14, and the first blade 23 is arranged in the first shell 14, and the first connecting pipe 15 is connected to the tangent direction of the first shell 14, and the other end of the first connecting pipe 15 is connected to the four-way pipe 3, and the other three ports of the four-way pipe 3 are connected to the The electric valve 4, when the material in the first connecting pipe 15 enters the first housing 14 along the tangential direction, it will drive the first blade 23; a second cylinder 5 is provided on one side of the plunger pump 11, and a third cylinder 54 is connected and fixed on the upper surface of the second cylinder 5, and a third piston 53 is slidably connected in the third cylinder 54, and a third housing 55 is connected and fixed on the upper surface of the third cylinder 54, and a second connecting pipe 56 is connected and fixed on the third housing 55, and the other end of the second connecting pipe 56 is connected and fixed on one of the electric valves 4, the second cylinder 5 is used for temporarily storing coolant, the third cylinder 54 is used for accommodating materials, the third piston 53 is used to cooperate with the third cylinder 54, and the second connecting pipe 56 is used to connect the electric valve 4 and the third housing 55;The lower surface of the third piston 53 is fixedly connected to a connecting rod 52, and the other end of the connecting rod 52 is fixedly connected to a second piston 51, and the second piston 51 is slidably connected to the second cylinder body 5. Two one-way valves 511 are connected and fixed to the lower surface of the second cylinder body 5, and the input end of one of the one-way valves 511 is connected and fixed to a second liquid inlet pipe 513, and the output end of the other one-way valve 511 is connected and fixed to a third connecting pipe 512. The third piston 53 drives the second piston 51 through the connecting rod 52. The second piston 51 is used to cooperate with the second cylinder body 5 and the two one-way valves 511 to realize the suction and discharge of the coolant. The second liquid inlet pipe 513 is used for cooling liquid input, and the third connecting pipe 5 12 is used for cooling liquid output; a jacket 57 is fixedly connected to the third cylinder 54, a spiral baffle 58 is fixedly connected inside the jacket 57, and the spiral baffle 58 is fixedly connected to the third cylinder 54, a liquid outlet pipe 59 is connected and fixed on one side of the outer wall of the jacket 57, a first liquid inlet pipe 510 is connected and fixed on the other side of the outer wall of the jacket 57, and the input end of the first liquid inlet pipe 510 is connected and fixed to the output end of the third connecting pipe 512, the spiral baffle 58 is used to guide the flow direction of the cooling liquid and increase the flow path, the jacket 57 is used to contain the cooling liquid, the liquid outlet pipe 59 is used to discharge the cooling liquid that has undergone heat exchange, and the first liquid inlet pipe 510 is used for cooling liquid input. ;

[0028] See also Figure 6 The present invention provides an embodiment: a process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets, comprising step one, preparation; step two, raw material input; step three, circulating homogenization; step four, raw material output;

[0029] In the above step 1, the two electric valves 4 are connected to the raw material input pipe and the output pipe respectively, the second liquid inlet pipe 513 is connected to the output end of the coolant storage tank, the liquid outlet pipe 59 is connected to the input end of the coolant radiator, the output end of the coolant radiator is connected to the input end of the coolant storage tank, the first piston 13 is adjusted to the top of the first cylinder 12 as the initial state, and the third piston 53 is adjusted to the top of the third cylinder 54 as the initial state;

[0030] In the above step 2, the electric valve 4 connected to the raw material input pipe is opened, the other electric valves 4 are closed, the plunger pump 11 is retracted, the raw material input pipe is fed, and after the raw material input is completed, the raw material input pipe stops feeding, and the electric valve 4 connected to the raw material input pipe is closed;

[0031] In the above step three, the electric valve 4 connected to the second connecting pipe 56 is opened, and the other electric valves 4 are closed, and the plunger pump 11 is started to drive the first piston 13 to perform reciprocating linear motion, so that the raw material continuously passes through the homogenizing component 2 for homogenization processing; wherein, when the first piston 13 moves downward, the raw material will enter the first shell 14 along the tangential direction, thereby driving the first blade 23, so that the connecting shaft 22 rotates, and the second shell 24 on the connecting shaft 22 rotates accordingly, and the second blade 26 in the second shell 24 moves accordingly, so as to clean the gap between the concentric annular groove 25 and the concentric annular body 29 to prevent blockage. When the first piston 13 performs reciprocating linear motion, the third piston 53 moves up and down, and the third piston 53 drives the second piston 51 through the connecting rod 52. The second piston 51 sucks the coolant in the coolant storage tank into the second cylinder 5, and then discharges the coolant in the second cylinder 5 into the jacket 57, and the coolant in the jacket 57 is discharged into the coolant radiator through the liquid outlet pipe 59, so as to realize the circulation of the coolant;

[0032] In the above step 4, after the homogenization process in step 3 is completed and the first piston 13 is in the initial state, the electric valve 4 connected to the raw material output pipe is opened, and the remaining electric valves 4 are closed, and the plunger pump 11 is extended to drive the first piston 13 to move upward, and the homogenized raw material is discharged into the raw material output pipe through the four-way pipe 3, and then the electric valve 4 connected to the raw material input pipe is opened, and the remaining electric valves 4 are closed, and the next raw material input action can be carried out.

[0033] Based on the above, the advantage of the present invention is that when the present invention is used, firstly, the two electric valves 4 are respectively connected to the raw material input pipe and the output pipe, the second liquid inlet pipe 513 is connected to the output end of the coolant storage tank, the liquid outlet pipe 59 is connected to the input end of the coolant radiator, the output end of the coolant radiator is connected to the input end of the coolant storage tank, the first piston 13 is adjusted to the top of the first cylinder 12 as the initial state, the third piston 53 is adjusted to the top of the third cylinder 54 as the initial state, the electric valve 4 connected to the raw material input pipe is opened, the remaining electric valves 4 are closed, the raw material input pipe is fed, the plunger pump 11 on the substrate 1 is retracted, and the first piston 13 is driven to move downward, and the raw material is supplied through the four-way pipe 3, the first connecting pipe 15, and the third connecting pipe 54. A shell 14 enters the first cylinder 12. After the raw material input is completed, the raw material input pipe stops feeding, the electric valve 4 connected to the raw material input pipe is closed, the electric valve 4 connected to the second connecting pipe 56 is opened, and the remaining electric valves 4 are closed. The plunger pump 11 is started, driving the first piston 13 to do reciprocating linear motion. When the first piston 13 moves up, the raw material will be input into the third cylinder 54 through the homogenizing component 2, the first shell 14, the first connecting pipe 15, the cross-tube 3, the second connecting pipe 56, and the third shell 55, and the third piston 53 in the third cylinder 54 will move down. When the first piston 13 moves down, the raw material will be sucked into the first cylinder 12, and the raw material will be homogenized again through the homogenizing component 2. At the same time, the third piston 53 in the third cylinder 54 will move up, and the raw material will enter When the raw material enters the homogenizing component 2, it will enter the through hole 27 from the truncated cone groove 28 on the second shell 24, and then enter the gap between the concentric ring body 29 and the concentric ring groove 25, and be broken into small particles, and then be discharged from the homogenizing component 2 through the through hole 27 on the other second shell 24. During the process of the raw material being sucked into the first cylinder body 12 through the cross-tube 3 and the homogenizing component 2, the raw material will enter along the tangential direction of the first shell 14, thereby driving the first blade 23, so that the connecting shaft 22 on the bracket 21 rotates, and the second shell 24 on the connecting shaft 22 rotates accordingly, and the second blade 26 in the second shell 24 moves accordingly, thereby cleaning the gap between the concentric ring groove 25 and the concentric ring body 29 to prevent blockage. During the process of the third piston 53 moving up and down, the second piston 51 will be driven through the connecting rod 52, The second piston 51 makes a reciprocating linear motion in the second cylinder 5. When the second piston 51 moves upward, the one-way valve 511 of the third connecting pipe 512 is in a closed state, and the one-way valve 511 of the second liquid inlet pipe 513 is in an open state, so that the coolant in the coolant storage tank is sucked into the second cylinder 5. When the second piston 51 moves downward, the one-way valve 511 of the third connecting pipe 512 is in an open state, and the one-way valve 511 of the second liquid inlet pipe 513 is in a closed state, so that the coolant in the second cylinder 5 is discharged into the first liquid inlet pipe 510 through the third connecting pipe 512, and then enters the jacket 57, and is transported upward along the spiral baffle 58. The upper coolant in the jacket 57 is discharged into the coolant radiator through the liquid outlet pipe 59, so as to realize the circulation of the coolant. After the homogenization treatment is completed,When the first piston 13 is in the initial state, the electric valve 4 connected to the raw material output pipe is opened, and the other electric valves 4 are closed. The plunger pump 11 extends, driving the first piston 13 to move upward, and the homogenized raw materials are discharged into the raw material output pipe through the cross-way pipe 3. Then the electric valve 4 connected to the raw material input pipe is opened, and the other electric valves 4 are closed, and the next raw material input action can be carried out.

[0034] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. A device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets, comprising a substrate (1), characterized in that: The base plate (1) is fixedly connected to a plunger pump (11), the plunger pump (11) is fixedly connected to a first cylinder (12), a first piston (13) is slidably connected in the first cylinder (12), and the first piston (13) is fixedly connected to the output end of the plunger pump (11), a homogenizing component (2) is arranged at the top end of the first piston (13), the homogenizing component (2) comprises a bracket (21), and the bracket (21) is fixedly connected in the first cylinder (12), the bracket ( A connecting shaft (22) is rotatably connected to the bracket (21), one end of the connecting shaft (22) is evenly distributed with a plurality of first blades (23), the connecting shaft (22) is fixedly connected to two second shells (24), and the second shells (24) are respectively arranged on both sides of the bracket (21), the second shells (24) are provided with concentric annular grooves (25), concentric annular bodies (29) are arranged in the concentric annular grooves (25), and the concentric annular bodies (29) are fixedly connected to the bracket (21).

2. The device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 1, characterized in that: A plurality of second blades (26) are evenly distributed on both sides of the concentric annular body (29), and the second blades (26) are fixedly connected in the concentric annular groove (25).

3. The device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 2, characterized in that: A plurality of through holes (27) are evenly distributed in the concentric annular groove (25), and one end of the through hole (27) is conductively connected to a truncated cone groove (28).

4. The device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 1, characterized in that: A first shell (14) is connected and fixed to the upper surface of the first cylinder body (12), and the first blade (23) is arranged in the first shell (14). A first connecting pipe (15) is connected and fixed in the tangential direction of the first shell (14), and a four-way pipe (3) is connected and fixed to the other end of the first connecting pipe (15), and the other three ports of the four-way pipe (3) are all connected and fixed to the electric valve (4).

5. The device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 1, characterized in that: A second cylinder (5) is provided on one side of the plunger pump (11); a third cylinder (54) is conductively fixed to the upper surface of the second cylinder (5); a third piston (53) is slidably connected inside the third cylinder (54); a third housing (55) is conductively fixed to the upper surface of the third cylinder (54); a second connecting pipe (56) is conductively fixed to the third housing (55); and the other end of the second connecting pipe (56) is conductively fixed to one of the electric valves (4).

6. The device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 5, characterized in that: The lower surface of the third piston (53) is fixedly connected to a connecting rod (52), the other end of the connecting rod (52) is fixedly connected to a second piston (51), and the second piston (51) is slidably connected to the inside of the second cylinder body (5). Two one-way valves (511) are connected and fixed to the lower surface of the second cylinder body (5), the input end of one of the one-way valves (511) is connected and fixed to a second liquid inlet pipe (513), and the output end of the other one-way valve (511) is connected and fixed to a third connecting pipe (512).

7. The device for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 5, characterized in that: The third cylinder body (54) is fixedly connected with a jacket (57), a spiral baffle (58) is fixedly connected inside the jacket (57), and the spiral baffle (58) is fixedly connected to the third cylinder body (54); a liquid outlet pipe (59) is connected and fixed to an outer wall on one side of the jacket (57); a first liquid inlet pipe (510) is connected and fixed to an outer wall on the other side of the jacket (57), and an input end of the first liquid inlet pipe (510) is connected and fixed to an output end of the third connecting pipe (512).

8. A process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets, comprising step 1, preparation; step 2, raw material input; step 3, circulating homogenization; step 4, raw material output; characterized in that: In the above step 1, the two electric valves (4) are connected to the raw material input pipe and the output pipe respectively, the second liquid inlet pipe (513) is connected to the output end of the coolant storage tank, the liquid outlet pipe (59) is connected to the input end of the coolant radiator, the output end of the coolant radiator is connected to the input end of the coolant storage tank, the first piston (13) is adjusted to the top of the first cylinder (12) to be the initial state, and the third piston (53) is adjusted to the top of the third cylinder (54) to be the initial state; In the above step 2, the electric valve (4) connected to the raw material input pipe is opened, the other electric valves (4) are closed, the plunger pump (11) is retracted, the raw material input pipe is fed, and after the raw material input is completed, the raw material input pipe stops feeding, and the electric valve (4) connected to the raw material input pipe is closed; In the above step 3, the electric valve (4) connected to the second connecting pipe (56) is opened, the other electric valves (4) are closed, and the plunger pump (11) is started to drive the first piston (13) to perform reciprocating linear motion, so that the raw material continuously passes through the homogenizing component (2) for homogenization processing; In the above step 4, after the homogenization process in step 3 is completed and the first piston (13) is in the initial state, the electric valve (4) connected to the raw material output pipe is opened, and the other electric valves (4) are closed, and the plunger pump (11) is extended to drive the first piston (13) to move upward, and the homogenized raw materials are discharged into the raw material output pipe through the four-way pipe (3), and then the electric valve (4) connected to the raw material input pipe is opened, and the other electric valves (4) are closed, and the next raw material input action can be carried out.

9. The process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 8, characterized in that: In the step three, when the first piston (13) moves downward, the raw material will enter the first housing (14) along the tangential direction, thereby driving the first blade (23), causing the connecting shaft (22) to rotate, and the second housing (24) on the connecting shaft (22) will rotate accordingly, and the second blade (26) in the second housing (24) will move accordingly, thereby cleaning the gap between the concentric annular groove (25) and the concentric annular body (29) to prevent blockage.

10. The process for improving the stability and bioavailability of thiamphenicol enteric-coated tablets according to claim 8, characterized in that: In the step 3, when the first piston (13) performs reciprocating linear motion, the third piston (53) moves up and down, and the third piston (53) drives the second piston (51) via the connecting rod (52). The second piston (51) sucks the coolant in the coolant storage tank into the second cylinder body (5), and then discharges the coolant in the second cylinder body (5) into the jacket (57). The coolant in the jacket (57) is discharged into the coolant radiator through the liquid outlet pipe (59), thereby realizing the circulation of the coolant.

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