Animal-derived implantable biomedical material treatment equipment and system

Abstract

The invention provides an animal-derived implantable biomedical material treatment device and system, and the animal-derived implantable biomedical material treatment device is used for degreasing casings and inactivating germs. The processing groove is formed in the top surface; at least part of the treatment frame is detachably arranged in the treatment tank, the side wall and the bottom surface of the treatment frame are of a net surface structure, and the treatment frame is configured to assemble the biomedical material and enable the biomedical material to be immersed in the treatment reagent; the oscillation device is arranged on the top surface and is configured as an oscillation processing frame, and the vibration frequency of the oscillation device is 0.5-10 Hz; and the inflation units are detachably arranged on the treatment frame. According to the casing processing device, multiple sets of casings are processed at the same time through the multiple processing frames, clustering of the casings is prevented, and the processing area of the casings is increased; the casing is bubbled and stirred by adopting the inflating unit, so that high temperature in the treatment tank is prevented, and the risk of material degeneration in the casing treatment process is reduced; and the casing can be turned over during treatment through bubbling and stirring, so that the treatment effect is improved.

Description

Technical Field

[0001] The present disclosure relates to the technical field of medical devices, and in particular to an animal-derived implantable biomedical material processing device and system. Background Art

[0002] The defects of certain tissues or organs and the partial or complete loss of functions caused by various diseases and traumas are one of the main hazards to human health. Research and development of ideal materials for tissue repair has always been an important topic in the fields of medicine, biological sciences, and materials science. Animal-derived decellularized ECM materials derived from the dermis, pericardium, small intestine and other tissues of pigs, horses, cattle and other animals have entered clinical applications.

[0003] Casing-type biomedical materials are widely used in medical devices. In order to ensure that their fat content, cell removal, DNA residue, etc. are qualified, they need to be processed. Here, ultrasonic treatment process is mainly used for processing. In the related technology, casings are placed in the processing tank and ultrasonic treatment is used to treat the casings. Due to the inherent characteristics of the ultrasonic process, the temperature of the liquid will gradually rise in the ultrasonic treatment process. The rate of temperature rise is affected by the amount of processed liquid, the amount of processed casings, the heat dissipation performance of the equipment, and the ambient temperature. Since the above factors are not easy to control, and casing-type biomedical materials are more sensitive to temperature, the instability of the processing liquid temperature will cause the performance of the casings to be uncontrollable, greatly increasing the application risk of the material. Summary of the invention

[0004] The purpose of the present disclosure is to provide an animal-derived implantable biomedical material processing device and system, which can solve at least one of the above-mentioned technical problems. The specific solution is as follows: According to the specific embodiments of the present disclosure, on the one hand, the present disclosure provides an animal-derived implantable biomedical material processing equipment for degreasing and inactivating pathogens of casings, the animal-derived implantable biomedical material processing equipment comprising: an operating table, the operating table having a top surface; a processing tank, the processing tank is opened on the top surface, the processing tank is configured to assemble processing reagents; a plurality of processing frames, the processing frames are at least partially detachably arranged in the processing tank, the side walls and the bottom surface of the processing frame are mesh structures, the processing frames are configured to assemble biomedical materials and immerse the biomedical materials in the processing reagents; an oscillating device, the oscillating device is arranged on the top surface, the oscillating device is configured to oscillate the processing frame, and the vibration frequency of the oscillating device is 0.5-10Hz; a plurality of inflation units, the inflation units are detachably arranged in the processing frames, and the inflation units are configured to inflate the processing frames.

[0005] In an optional embodiment, the vibration frequency F of the vibration device satisfies the following formula: , Wherein, F is the vibration frequency of the vibration device, W D is the total weight of the biomedical material in a wet state to be treated.

[0006] In an optional embodiment, the inflation unit includes: a gas supply pipeline and multiple branches, the gas supply pipeline and the branches are hollow, one end of the branch is connected to one end of the gas supply pipeline, and the branch is provided with multiple air outlets, and the air outlets are configured to inflate the processing reagent in the processing frame.

[0007] In an optional embodiment, the animal-derived implantable biomedical material processing equipment further includes: a frame structure, which is disposed on the top surface; and the frame structure is configured to assemble the processing frame.

[0008] In an optional embodiment, the processing tank is located at one end of the top surface and has a first edge and a second edge that are roughly parallel, the first edge is located at both ends of the top surface and has a first guide rail, and the second edge is located at both ends of the top surface and has a second guide rail; the frame structure is provided with a plurality of rotating wheels, and the plurality of rotating wheels are respectively arranged on the first guide rail and the second guide rail, so that the frame structure can move on the first guide rail and the second guide rail.

[0009] In an optional embodiment, the oscillating device is connected to the frame structure, and the oscillation direction of the oscillating device is the same as the movement direction of the frame structure.

[0010] In an optional embodiment, the oscillation device is a linear reciprocating motor.

[0011] In an optional embodiment, the animal-derived implantable biomedical material processing equipment further includes: a circulation pipeline, both ends of which are connected to the interior of the processing tank, and a filtering device is provided on the circulation pipeline.

[0012] In an optional embodiment, the animal-derived implantable biomedical material processing equipment further includes: a cooling device, which is disposed in the circulation pipeline and is configured to cool the processing reagent in the circulation pipeline.

[0013] According to a specific embodiment of the present disclosure, on the other hand, the present disclosure provides an animal-derived implantable biomedical material processing system, and the animal-derived implantable biomedical material processing system includes: an animal-derived implantable biomedical material processing device as described in any one of the above technical solutions.

[0014] In an optional embodiment, the animal-derived implantable biomedical material processing system further includes: an air pump, wherein the air delivery end of the air pump is connected to the air delivery pipeline and is configured to introduce air into the processing reagent in the processing frame.

[0015] In an optional embodiment, the air delivery pressure of the air pump is 0.1-1 MPa.

[0016] Compared with the prior art, the above solution of the embodiment of the present disclosure has at least the following beneficial effects: The present invention realizes the simultaneous processing of multiple groups of casings by adopting multiple processing frames, thereby preventing the casings from clumping and increasing the processing area of ​​the casings; and an inflation unit is used to bubble and stir the casings with compressed air, thereby preventing the temperature in the processing tank from being high and reducing the risk of material denaturation during the casing processing; the bubbling and stirring can cause the casings to roll during processing, thereby increasing the processing effect; and simultaneous processing by multiple processing frames greatly improves the safety of medical devices. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A schematic structural diagram of an animal-derived implantable biomedical material processing device according to an embodiment of the present disclosure is shown.

[0018] Figure 2 A schematic structural diagram of an animal-derived implantable biomedical material processing device according to another embodiment of the present disclosure is shown.

[0019] Figure 3 A schematic structural diagram of a processing frame in another embodiment of the present disclosure is shown.

[0020] Figure 4 A schematic structural diagram of an inflation unit according to another embodiment of the present disclosure is shown.

[0021] Figure 5 A schematic structural diagram of an animal-derived implantable biomedical material processing device according to another embodiment of the present disclosure is shown.

[0022] Reference numerals: 100: operating table; 110: top surface; 200: processing tank; 300: Processing frame; 400: oscillation device; 500: charging unit; 510: gas pipeline; 520: branch line; 521: air outlet; 600: frame structure; 610: first guide rail; 620: second guide rail; 630: rotating wheel; 700: Circulation pipeline. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solutions and advantages of the present disclosure clearer, the present disclosure will be further described in detail below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present disclosure, rather than all of the embodiments. Based on the embodiments in the present disclosure, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present disclosure.

[0024] The terms used in the embodiments of the present disclosure are only for the purpose of describing specific embodiments, and are not intended to limit the present disclosure. The singular forms "a", "said" and "the" used in the embodiments of the present disclosure and the appended claims are also intended to include plural forms, unless the context clearly indicates other meanings, and "multiple" generally includes at least two.

[0025] It should be understood that the term "and / or" used in this article is only a description of the association relationship of associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in this article generally indicates that the associated objects before and after are in an "or" relationship.

[0026] It should be understood that although the terms first, second, third, etc. may be used to describe structures in the disclosed embodiments, these structures should not be limited to these terms. These terms are only used to distinguish different structures. For example, without departing from the scope of the disclosed embodiments, a first component may also be referred to as a second component, and similarly, a second component may also be referred to as a first component.

[0027] As used herein, the words "if" and "if" may be interpreted as "at the time of" or "when" or "in response to determining" or "in response to detecting", depending on the context. Similarly, the phrases "if it is determined" or "if (stated condition or event) is detected" may be interpreted as "when it is determined" or "in response to determining" or "when detecting (stated condition or event)" or "in response to detecting (stated condition or event)", depending on the context.

[0028] It should also be noted that the term "includes", "comprising" or any other variation thereof is intended to cover non-exclusive inclusion, so that a commodity or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such commodity or device. In the absence of more restrictions, the elements defined by the sentence "comprising a ..." do not exclude the existence of other identical elements in the commodity or device including the elements.

[0029] In the related art, due to the inherent characteristics of the ultrasonic process, the temperature of the liquid in the ultrasonic treatment process will gradually rise. The rate of temperature rise is affected by the amount of treated liquid, the amount of treated casings, the heat dissipation performance of the equipment, and the ambient temperature. Since the above factors are not easy to control, and the casing biomedical materials are sensitive to temperature, the instability of the treatment liquid temperature will lead to uncontrollable performance of the casings, greatly increasing the application risk of the material; because the casings themselves have many wrinkles and are easy to float to the surface of the treatment liquid or sink to the bottom of the tank (determined by the density of the treatment liquid), the treatment liquid that reacts in the casing gathering area is not easy to spread to other areas, especially the outer tank. The ultrasonic treatment method has no effect on the movement of the casings, because the casings are easy to float to the surface of the treatment liquid or sink to the bottom of the tank (determined by the density of the treatment liquid), resulting in the casings exposed to the liquid surface or the casings wrapped inside cannot fully contact the treatment liquid, and the treated casings are easy to entangle and difficult to separate, which can easily lead to inconsistency in casing treatment, forming uncontrollable risks. The related technology generally adopts a universal processing tank with a relatively large bottom area, which makes it impossible to process when the casing processing volume is small and the processing liquid is not fully utilized.

[0030] In order to solve at least one of the technical problems mentioned above, the present disclosure provides an animal-derived implantable biomedical material processing device and system, which are used for degreasing and inactivating pathogens in intestine casings. The animal-derived implantable biomedical material processing device includes: an operating table 100, wherein the operating table 100 has a top surface 110; a processing tank 200, wherein the processing tank 200 is opened on the top surface 110, and the processing tank 200 is configured to assemble a processing reagent; and a plurality of processing frames 300, wherein the processing frames 300 are at least partially detachable and arranged on the top surface 110. The side walls and the bottom surface of the processing tank 200 and the processing frame 300 are mesh structures, and the processing frame 300 is configured to assemble biomedical materials and immerse the biomedical materials in the processing reagent; an oscillating device 400, the oscillating device 400 is arranged on the top surface 110, and the oscillating device 400 is configured to oscillate the processing frame 300, and the vibration frequency of the oscillating device 400 is 0.5-10Hz; a plurality of inflation units 500, the inflation units 500 are detachably arranged on the processing frame 300, and the inflation units 500 are configured to inflate the processing frame 300. The present invention realizes the simultaneous processing of multiple groups of casings by adopting multiple processing frames 300, thereby preventing the casings from clumping and increasing the processing area of ​​the casings; and, adopts an inflation unit 500 to bubble and stir the casings with compressed air, thereby preventing the high temperature in the processing tank 200 and reducing the risk of material denaturation during the casing processing; the bubbling and stirring can cause the casings to roll during processing, thereby increasing the processing effect; the simultaneous processing of multiple processing frames 300 has a significant improvement in the safety of medical devices.

[0031] The optional embodiments of the present disclosure are described in detail below with reference to the accompanying drawings.

[0032] Figure 1 A schematic structural diagram of an animal-derived implantable biomedical material processing device according to an embodiment of the present disclosure is shown. Figure 2 A schematic structural diagram of an animal-derived implantable biomedical material processing device according to another embodiment of the present disclosure is shown. Figure 3 FIG. 3 shows a schematic diagram of the structure of a processing block 300 according to another embodiment of the present disclosure. Figure 1 , Figure 2 and Figure 3 As shown, according to a specific embodiment of the present disclosure, on the one hand, an animal-derived implantable biomedical material processing device is provided, and the animal-derived implantable biomedical material processing device is used for degreasing and inactivating pathogens of casings, and the animal-derived implantable biomedical material processing device comprises: an operating table 100, and the operating table 100 has a top surface 110; a processing tank 200, and the processing tank 200 is opened on the top surface 110, and the processing tank 200 is configured to assemble a processing reagent; a plurality of processing frames 300, and the processing frames 300 are at least partially detachable and arranged in the processing tank 200, and the side walls and the bottom surface of the processing frame 300 are mesh structures, and the processing frames 300 are configured to assemble biomedical materials and make the biomedical materials immersed in the processing reagent; an oscillating device 400, and the oscillating device 400 is arranged on the top surface 110, and the oscillating device 400 is configured to oscillate the processing frame 300, and the vibration frequency of the oscillating device is 0.5-10Hz.

[0033] The present disclosure realizes the simultaneous processing of multiple groups of casings by adopting multiple processing frames 300, thereby preventing the casings from clumping and increasing the processing volume of the casings; the simultaneous processing of multiple processing frames 300 has a high improvement in the safety of medical devices. In an optional embodiment, when the processing frame 300 is assembled in the processing tank 200, the distance between the bottom surface of the processing frame 300 and the bottom surface of the processing tank 200 is controlled to be less than 30 mm. In an optional embodiment, when the processing frame 300 is assembled in the processing tank 200, the distance between the outermost processing frame 300 and the side wall of the processing tank 200 is controlled to be less than 20 mm. In an optional embodiment, when the processing frame 300 is assembled in the processing tank 200, the distance between two adjacent processing frames 300 is controlled to be less than 60 mm.

[0034] In some embodiments, it is found that the frequency of oscillation has a certain influence on the processing result of the casings as the processing amount of the casings changes. Taking fat removal as an example, an alcohol treatment solution is added to the processing tank for 180 minutes. The casings after treatment are sent for inspection of fat content. After drying and crushing, the casings are tested with reference to the acid hydrolysis method of GB5009.6-2016. By comparing the degreasing effect, it can be seen that for casings with different processing amounts, the fat content of the casings decreases with the increase of the vibration frequency. When a certain vibration frequency is reached, the fat content of the casings tends to be stable. For details of some experimental data, please refer to the table below.

[0035]

[0036] Note: 0Hz means no oscillation is used, and the other parameters are the same as those of other groups of experiments.

[0037] The fat content of casings after being processed at different frequencies is shown in the table above; In several groups of experiments, the 4kg experiment started at 2Hz, the 10g experiment started at 4Hz, the 20kg experiment started at 6Hz, the 30kg experiment started at 8Hz, and the 45kg experiment started at 12Hz. The casings were all damaged after treatment (torn, broken or even shattered, and in the 4kg experiment, the 9Hz and 12Hz casings were already shattered).

[0038] In several groups of experiments, the 4kg experiment started at 0.8Hz, the 10g experiment started at 2Hz, the 20kg experiment started at 4Hz, the 30kg experiment started at 6Hz, and the 45kg experiment started at 9Hz. The fat content of the casings after treatment decreased significantly. Combined with the above damage data, it can be seen that by using the oscillation method disclosed in the present invention, the fat content of biomedical materials (casings) of different weights will be significantly reduced under a certain range of oscillation frequencies without damage. Through further research on the properties and arrangement of casing fat molecules, the following formula is obtained: In some embodiments, the vibration frequency F of the vibration device satisfies the following formula: , Wherein, F is the vibration frequency of the vibration device, W D is the total weight of the biomedical material in a wet state to be treated. Example 1

[0039] The vibration frequency F of the vibration device satisfies the following formula: , 4kg, 10kg, 20kg, 30kg and 45kg casings with a fat content of 7.68% were treated with the above oscillation frequency respectively. After 180 minutes of treatment, the casings were sent for fat content testing. After drying and crushing, the casings were tested with reference to the acid hydrolysis method of GB5009.6-2016, and the untreated casings were used as a comparison. Example 2

[0040] The vibration frequency F of the vibration device satisfies the following formula: .

[0041] 4kg, 10kg, 20kg, 30kg and 45kg casings with a fat content of 7.68% were treated with the above oscillation frequency. After 180 minutes of treatment, the casings were sent for fat content testing using the same testing method as in Implementation Case 1.

[0042] Comparative Example 1 4kg, 10kg, 20kg, 30kg and 45kg of casings with a fat content of 7.68% were treated with degreasing liquid in a non-oscillating mode. After 180 minutes of treatment, the casings were sent for fat content testing as blank comparison example 1. The testing method was the same as that in implementation case 1.

[0043] Casing fat content test method: 1. Dry the casing, crush it with scissors and grinding equipment, then weigh about 2g~5g, accurate to 0.001g, put it in a 50mL test tube, add 8mL of water, mix well, and then add 10mL of hydrochloric acid. Put the test tube in a 70℃~80℃ water bath, stir it with a glass rod every 5min~10min until the sample is completely digested, about 40min~50min.

[0044] 2. Take out the test tube, add 10mL ethanol and mix. After cooling, transfer the mixture into a 100mL stoppered measuring cylinder, wash the test tube several times with 25mL anhydrous ether, and pour it into the measuring cylinder. After all the anhydrous ether is poured into the measuring cylinder, add a stopper and shake for 1min, carefully unscrew the stopper, release the gas, re-stopper, let it stand for 12min, carefully unscrew the stopper, and rinse the stopper and the fat attached to the mouth of the measuring cylinder with ether. Let it stand for 10min~20min, wait for the upper liquid to be clear, suck out the supernatant into a constant-weight conical flask, add 5mL anhydrous ether into the stoppered measuring cylinder, shake, let it stand, and still suck out the upper ether and put it into the original conical flask.

[0045] 3. Evaporate to dryness in a water bath. Dry at 100℃±5℃ for 1 hour, cool in a desiccator for 0.5 hour and weigh. Repeat the above steps until constant weight is achieved (until the difference between two weighings does not exceed 2 mg).

[0046] After testing by the above method, the fat content of the casings after being treated in Example 1, Example 2 and Comparative Example 1 is as follows:

[0047] It can be seen from the above table that the weight fat content of the casings after treatment in Example 1 and Example 2 is significantly lower than the weight fat content of the casings after treatment in the comparative example. It can be seen that the treatment using the vibration frequency of Example 1 and Example 2 is more thorough, and the excess fat, cells and DNA are removed more clearly, and the fat removal effect is better. By comparing Example 1 and Example 2, it can be seen that the weight fat content of Example 2 after treatment is slightly greater than that of Example 1, which are casings of the same batch with the same weight before treatment; from the experimental data, it can be seen that the vibration frequency in Example 1 is slightly greater than that in Example 2, therefore, under the premise of not damaging the casings, the higher the vibration frequency, the cleaner the treatment, and the upper limit of the vibration frequency adopted in the present disclosure is to prevent the casings from being damaged under high-frequency vibration.

[0048] Figure 4 The structural schematic diagram of the gas filling unit 500 in another embodiment of the present disclosure is shown. In some embodiments, the animal-derived implantable biomedical material processing device further includes a plurality of gas filling units 500, the gas filling units 500 are detachably arranged on the processing frame 300, and the gas filling units 500 are configured to fill the processing frame 300; wherein, the gas filling unit 500 includes: a gas supply pipeline 510 and a plurality of branches 520, the gas supply pipeline 510 and the branches 520 are hollow, one end of the branch 520 is connected to one end of the gas supply pipeline 510, and the branch 520 is provided with a plurality of air outlets 521, and the air outlets 521 are configured to fill the processing reagent of the processing frame 300. The present disclosure adopts the gas filling unit 500 to bubble and stir the casing by compressed air, thereby preventing the temperature in the processing tank 200 from being high and reducing the risk of material degeneration during the casing processing; the casing can be rolled during the processing by bubbling and stirring, thereby increasing the processing effect.

[0049] Figure 5 FIG. 2 shows a schematic diagram of a structure of an animal-derived implantable biomedical material processing device according to another embodiment of the present disclosure. Figure 5As shown, in some embodiments, the animal-derived implantable biomedical material processing equipment further includes: a frame structure 600, and the frame structure 600 is arranged on the top surface 110; the frame structure 600 is configured to assemble the processing frame 300. In an optional embodiment, the processing tank 200 is located at one end of the top surface 110 and has a first edge and a second edge that are substantially parallel, and the first edge is located at both ends of the top surface 110 and is provided with a first guide rail 610, and the second edge is located at both ends of the top surface 110 and is provided with a second guide rail 620; the frame structure 600 is provided with a plurality of rotating wheels 630, and the plurality of rotating wheels 630 are respectively arranged on the first guide rail 610 and the second guide rail 620, so that the frame structure 600 moves on the first guide rail 610 and the second guide rail 620. In an optional embodiment, the oscillation device 400 is connected to the frame structure 600, and the oscillation direction of the oscillation device 400 is the same as the movement direction of the frame structure 600. In an optional implementation, the oscillation device 400 is a linear reciprocating motor. As Figure 5 As shown, the frame structure 600 can be equipped with a plurality of the processing frames 300. At the same time, the frame structure 600 is arranged on the top surface 110 near the processing tank 200 through pulleys and slide rails. When the oscillating device 400 is working, the oscillating device 400 drives the frame structure 600 to move back and forth on the slide rails (the first guide rail 610 and the second guide rail 620), and the frame structure 600 drives the processing frame 300 to move synchronously, thereby completing the processing of the animal-derived implantable biomedical material (casing). In an optional embodiment, the movable distance of the frame structure 600 is 20-80 mm; in a preferred embodiment, the movable distance of the frame structure 600 is 50 mm.

[0050] In some embodiments, the animal-derived implantable biomedical material processing equipment further includes: a circulation pipeline 700, both ends of which are connected to the interior of the processing tank 200, and a filtering device is provided on the circulation pipeline 700. In an optional embodiment, the animal-derived implantable biomedical material processing equipment further includes: a cooling device, which is provided in the circulation pipeline 700, and the cooling device is configured to cool the treatment reagent in the circulation pipeline 700. The animal-derived implantable biomedical material processing equipment disclosed in the present invention increases the internal treatment reagent circulation system, draws the treatment reagent from one side of the tank, and pumps the treatment reagent out from the other side through a centrifugal pump to realize the circulation of the entire tank system; and when the treatment reagent passes through the circulation pipeline 700, the circulation pipeline 700 filters and cools the treatment reagent, and while discharging the impurities washed out by the treatment reagent, cools the treatment reagent, thereby reducing the risk of material degeneration during casing processing. In an optional embodiment, a temperature sensor is provided in the processing tank 200, and the temperature sensor is configured to obtain the temperature in the processing tank 200, and the degree of cooling of the processing reagent by the cooling device is controlled by the temperature obtained by the temperature sensor.

[0051] Specifically, the design dimensions of the processing tank 200 are: length 900mm×width 560mm×height 600mm, the design dimensions of the processing frame 300 are: length 250mm×width 250mm×height 570mm, the frame structure 600 accommodates 2*3 (6) processing frames 300, 3 processing frames 300 are assembled in the length direction of the processing tank 200, and 2 processing frames 300 are assembled in the width direction of the processing tank 200; at the same time, the setting direction of the first guide rail 610 and the second guide rail 620 is the length direction of the processing tank 200; the frame structure 600 is respectively provided with linear reciprocating motors at both ends in the length direction, and the movement direction of the linear reciprocating motor is the length direction of the processing tank 200, and the free ends of the two linear reciprocating motors are respectively fixed to the frame structure 600, and the linear reciprocating motors located at both ends of the frame structure 600 have opposite movement directions and other working parameters are consistent. When the processing frame 300 is assembled in the processing tank 200, the distance between the bottom surface of the processing frame 300 and the bottom surface of the processing tank 200 is controlled to be less than 30 mm, the distance between the outermost processing frame 300 and the side wall of the processing tank 200 is controlled to be less than 20 mm, and the distance between two adjacent processing frames 300 is controlled to be less than 60 mm.

[0052] When the animal-derived implantable biomedical material processing equipment is used, an appropriate amount of the processing reagent is injected into the processing tank 200, the processing frame 300 is assembled on the frame structure 600, the inflation unit 500 is placed one-to-one inside the processing frame 300, and then the animal-derived implantable biomedical material (casing) to be processed is placed in the processing frame 300 so that the branch 520 is located between the bottom surface of the processing frame 300 and the casing, and the air pump is turned on to continuously fill the inflation unit 500 with compressed air.

[0053] According to a specific embodiment of the present disclosure, on the other hand, an animal-derived implantable biomedical material processing system is provided, and the animal-derived implantable biomedical material processing system includes: an animal-derived implantable biomedical material processing device as described in any one of the above embodiments.

[0054] In some embodiments, the animal-derived implantable biomedical material processing system further comprises: an air pump, the air delivery end of the air pump is connected to the air delivery pipeline 510, and is configured to pass air into the processing reagent of the processing frame 300. In an optional embodiment, the air delivery pressure of the air pump is 0.1-1MPa. In an optional embodiment, for convenience during use, compressed air is used as the air source of the air.

[0055] The present disclosure aims to protect an animal-derived implantable biomedical material processing device and system, the animal-derived implantable biomedical material processing device and system are used for degreasing and inactivating pathogens of casings, the animal-derived implantable biomedical material processing device comprises: an operating table 100, the operating table 100 having a top surface 110; a processing tank 200, the processing tank 200 is opened on the top surface 110, the processing tank 200 is configured to assemble a processing reagent; a plurality of processing frames 300, the processing frames 300 are at least partially detachably arranged in the processing tank 200, The side walls and the bottom surface of the processing frame 300 are mesh structures, and the processing frame 300 is configured to assemble biomedical materials and immerse the biomedical materials in the processing reagent; an oscillating device 400, the oscillating device 400 is arranged on the top surface 110, the oscillating device 400 is configured to oscillate the processing frame 300, and the vibration frequency of the oscillating device 400 is 0.5-10Hz; a plurality of inflation units 500, the inflation units 500 are detachably arranged on the processing frame 300, and the inflation units 500 are configured to inflate the processing frame 300. The present invention realizes the simultaneous processing of multiple groups of casings by adopting multiple processing frames 300, thereby preventing the casings from clumping and increasing the processing area of ​​the casings; and, adopts an inflation unit 500 to bubble and stir the casings with compressed air, thereby preventing the high temperature in the processing tank 200 and reducing the risk of material denaturation during the casing processing; the bubbling and stirring can cause the casings to roll during processing, thereby increasing the processing effect; the simultaneous processing of multiple processing frames 300 has a significant improvement in the safety of medical devices.

[0056] Finally, it should be noted that the various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other. For the system or device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part description.

[0057] The above embodiments are only used to illustrate the technical solutions of the present disclosure, rather than to limit them. Although the present disclosure has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present disclosure.

Claims

1. An animal-derived implantable biomedical material processing device for degreasing and inactivating pathogens in sausage casings, characterized in that: include: An operating table, the operating table having a top surface; a processing tank, the processing tank being opened on the top surface and configured to hold a processing reagent; A plurality of processing frames, wherein at least part of the processing frames are detachably disposed in the processing tank, the side walls and the bottom surface of the processing frames are mesh structures, and the processing frames are configured to assemble biomedical materials and allow the biomedical materials to be immersed in the processing reagent; an oscillating device, the oscillating device being disposed on the top surface, the oscillating device being configured to oscillate the processing frame, and the oscillation frequency of the oscillating device being 0.5-10 Hz; A plurality of inflatable units are detachably mounted on the processing frame, and the inflatable units are configured to inflate the processing frame.

2. The animal-derived implantable biomedical material processing device according to claim 1, characterized in that: The vibration frequency F of the vibration device satisfies the following formula: ， Wherein, F is the vibration frequency of the vibration device, W D is the total weight of the biomedical material in a wet state to be treated.

3. The animal-derived implantable biomedical material processing device according to claim 1, characterized in that: The inflation unit includes: an air supply pipeline and multiple branches, the air supply pipeline and the branches are hollow, one end of the branch is connected to one end of the air supply pipeline, the branch is provided with multiple air outlets, and the air outlets are configured to inflate the processing reagent in the processing frame.

4. The animal-derived implantable biomedical material processing device according to claim 1, characterized in that: Also includes: A frame structure, the frame structure being arranged on the top surface; The frame structure is configured to mount the process frame.

5. The animal-derived implantable biomedical material processing device according to claim 4, characterized in that: The processing tank has a first edge and a second edge which are substantially parallel to each other at one end of the top surface, the first edge is located at both ends of the top surface and is provided with a first guide rail, and the second edge is located at both ends of the top surface and is provided with a second guide rail; The frame structure is provided with a plurality of rotating wheels, and the plurality of rotating wheels are respectively arranged on the first guide rail and the second guide rail, so that the frame structure can move on the first guide rail and the second guide rail.

6. The animal-derived implantable biomedical material processing device according to claim 5, characterized in that: The oscillating device is connected to the frame structure, and the oscillation direction of the oscillating device is the same as the movement direction of the frame structure.

7. The animal-derived implantable biomedical material processing device according to claim 1, characterized in that: The oscillating device is a linear reciprocating motor.

8. The animal-derived implantable biomedical material processing device according to claim 1, characterized in that: Also includes: A circulation pipeline, both ends of which are connected to the interior of the treatment tank, and a filtering device is provided on the circulation pipeline.

9. The animal-derived implantable biomedical material processing device according to claim 8, characterized in that: Also includes: A cooling device is provided in the circulation pipeline, and the cooling device is configured to cool the processing reagent in the circulation pipeline.

10. An animal-derived implantable biomedical material processing system, characterized in that: include: The animal-derived implantable biomedical material processing equipment and air pump as described in any one of claims 1-7, wherein the air delivery end of the air pump is connected to the air delivery pipeline and is configured to introduce air into the processing reagent in the processing frame.

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