Method for degrading paracetamol in fresh urine by periodate

Abstract

The invention discloses a method for degrading paracetamol in fresh urine by periodate, and particularly relates to a method for degrading drug paracetamol ACE in fresh urine FU by periodate PI, the method comprises the following steps: adding periodate PI into the to-be-treated paracetamol ACE-polluted fresh urine FU, and uniformly mixing to realize rapid and efficient degradation of ACE; the PI / FU system established by the invention can achieve synergistic interaction to promote generation of singlet oxygen and hydroxyl free radicals, so that the purpose of quickly and efficiently degrading ACE is achieved; the method does not need extra energy supply, does not need any external activator, greatly reduces the cost, has the advantages of efficient ACE degradation, environmental friendliness and the like, and has wide application prospects in the aspects of guaranteeing water ecological safety and safe resource utilization of urine.

Description

Technical Field

[0001] The invention relates to the technical field of paracetamol degradation, and in particular to a method for degrading paracetamol in fresh urine using periodate. Background Art

[0002] Human urine is part of urban wastewater. Although its volume is less than 1% of the total volume, it is one of the main sources of pharmaceutical pollutants in wastewater. As one of the most commonly used analgesics, paracetamol ACE has an annual global consumption of more than 140,000 tons. After patients take ACE, only 5-15% can be absorbed by the body, and 58% to 68% are excreted in urine. However, the technology of most sewage treatment plants mainly targets substances such as nitrogen and phosphorus, and it is difficult to remove ACE efficiently. As a result, ACE is widely detected in the environment and may cause great harm to aquatic organisms, such as damaging the liver of freshwater fish and affecting the biological nervous system. Therefore, it is urgent to develop a treatment method for ACE-contaminated urine.

[0003] Advanced oxidation processes (AOPs) based on strong oxidative free radicals (such as hydroxyl radicals (·OH)) are often used to remove refractory organic pollutants in water. However, many AOPs are significantly limited for complex media such as urine. This is because urine contains high concentrations of HCO3 - NH4 + , Cl - Plasma, these substances will quench OH or convert it into less active species, inhibiting the degradation of pollutants. At the same time, urea in fresh urine FU will be hydrolyzed into NH3 and NH4 under the action of microorganisms. + and HCO3 - , forming alkaline hydrolyzed urine (HU), but this process will lose some nitrogen. Given that the organic components in FU are more complex, previous studies have mostly focused on treating pollutants in HU. For example, Zhang et al. used ultraviolet light to activate peroxydisulfate (PDS) to degrade sulfonamide antibiotics in HU, and Kung et al. used sunlight to drive PDS to remove caffeine and cefotaxime from HU. For ACE in HU, Nie Minghua et al. invented a treatment method using peroxymonosulfate (PMS) (authorization announcement number: CN113087122B) and achieved good results. However, most of the above methods require the addition of multiple reagents or energy (such as oxidants, activators and light), and are only applicable to HU, limiting their large-scale application.

[0004] In recent years, there has been an increasing number of studies on the degradation of pollutants based on PI. PI is a strong oxidant with a reduction potential of +1.6 V. Compared with other common oxidants (such as H2O2, O3, etc.), PI has stronger chemical stability and its solid state enables long-distance transportation and long-term storage. Most previous studies have used various activation methods to activate PI to form active species (RS) to remove pollutants. The activation methods are divided into three types: (1) homogeneous activation (Mn 2+ , Fe 2+ , H2O2, etc.); (2) heterogeneous activation (iron-based materials, TiO2-based materials, carbon materials, zinc-based materials and other metal oxides); (3) direct activation (freezing, light, heating, alkali). For example, Li et al. used Cu2O to activate PI to remove antibiotics in water, Zhang Yue et al. used water hyacinth biochar combined with PI to remove sulfadiazine (SD) in water, and Ye et al. used sunlight combined with PI to treat Gram-positive bacteria. For HU, Cai Tianming et al. constructed a biochar combined with PI system and found that electrons can be transferred from biochar to PI and form a high-potential metastable complex (biochar-PI*), thereby effectively removing SD. However, the above methods usually require external energy or chemical consumption, are costly, have high energy consumption, and may also produce heavy metal pollution and increase the risk of secondary pollution. In order to avoid the above shortcomings, it is particularly important to develop PI treatment technology without external activation means. However, the use of PI alone to degrade pollutants such as ACE has not been reported. Summary of the invention

[0005] The purpose of the present invention is to overcome the shortcomings of the prior art, and provide a method for degrading paracetamol in fresh urine by using periodate, namely, a method for degrading paracetamol ACE in fresh urine FU by using periodate PI. The method comprises the following steps: adding periodate PI to fresh urine FU contaminated with paracetamol ACE to be treated, and mixing uniformly to achieve rapid and efficient degradation of ACE; the PI / FU system established by the present invention can synergistically promote the generation of singlet oxygen and hydroxyl free radicals, so as to achieve the purpose of rapid and efficient degradation of ACE; the present invention does not require additional energy supply, does not require any exogenous addition of any activator, greatly reduces the cost, has the advantages of efficient degradation of ACE, environmental friendliness, etc., and has broad application prospects in ensuring water ecological safety and safe resource utilization of urine.

[0006] In order to achieve the above technical effects, the following technical solutions are adopted:

[0007] A method for degrading paracetamol in fresh urine using periodate is as follows: using periodate PI as an oxidant to directly degrade the drug paracetamol ACE in fresh urine FU at room temperature; specifically comprising the following steps:

[0008] Step S1: collecting fresh urine FU, wherein the fresh urine FU contains the drug paracetamol ACE;

[0009] Step S2: adding periodate PI to the fresh urine FU containing the drug paracetamol ACE in step S1, stirring and mixing evenly, and then obtaining urine in which the drug paracetamol ACE is degraded after the reaction is completed.

[0010] Furthermore, the main components of the fresh urine FU include: urea, NaCl, Na2SO4, KCl, MgCl2·6H2O, NaH2PO4·2H2O, CaCl2, trisodium citrate dihydrate and water.

[0011] Furthermore, the concentration of the drug paracetamol ACE in fresh urine FU is 3-9 mmol / L.

[0012] Furthermore, the storage conditions of the fresh urine FU are: storing the urine FU at a temperature below 4° C. and away from light; the time from the collection of the fresh urine FU to its use does not exceed 24 hours.

[0013] Furthermore, the pH value of the fresh urine FU is 6-9.

[0014] Furthermore, the periodate PI includes sodium periodate.

[0015] Furthermore, the concentration of the periodate PI in fresh urine FU is 0.5-4 mmol / L.

[0016] Furthermore, the stirring speed is 100-300 rpm.

[0017] Furthermore, the reaction time is 30-90 min.

[0018] Furthermore, the reaction temperature is 15-40°C.

[0019] The beneficial effects of the present invention are:

[0020] 1. The purpose of the present invention is to introduce periodate PI into fresh urine FU to form a PI / FU system to achieve the degradation of organic pollutants in fresh urine FU; the operation is simple, the reaction conditions are mild, the energy consumption is low, no additional energy supply is required, no exogenous addition of any activator is required, and toxic metal ions can be prevented from entering the ecosystem to cause secondary pollution. It has the characteristics of economy and environmental protection, strong adaptability, and broad application prospects.

[0021] 2. The degradation efficiency of the paracetamol ACE drug in the fresh urine FU of the present invention is high. After the paracetamol ACE-contaminated fresh urine FU is treated for 50 minutes, the degradation rate of ACE can reach 100.00%.

[0022] 3. The periodate PI used is inexpensive, safe, stable, and easy to store and transport. Its use can also avoid the problem of secondary pollution of the water after treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. The drawings in the following description are merely embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0024] Figure 1 It is the degradation curve diagram of ACE by different systems of the present invention;

[0025] Figure 2 The degradation curve of ACE under different PI dosage conditions of the present invention;

[0026] Figure 3 This is a degradation curve diagram of ACE under different ACE concentration conditions of the present invention;

[0027] Figure 4 The degradation curve of ACE under different liquid temperature conditions of the present invention;

[0028] Figure 5 This is a degradation curve diagram of ACE under different pH conditions of the present invention;

[0029] Figure 6 It is the degradation curve diagram of ACE under different PI addition modes of the present invention;

[0030] Figure 7 The degradation curve of ACE in the presence of different anions of the present invention;

[0031] Figure 8 The degradation curve of ACE in the presence of different cations of the present invention;

[0032] Fig. 9 RS in the present invention (ascorbic acid AA for all RS, histidine L-His for 1 O2) Contribution of ACE in the degradation of urinary FU;

[0033] Fig.10 RS in the present invention (phenol PhOH for IO3 and IO4, nitro blue tetrazolium NBT for O2 ·- ) Contribution of ACE in the degradation of urinary FU;

[0034] Fig.11This is the contribution diagram of RS (tert-butyl alcohol TBA to ·OH) in the degradation of ACE in urine FU in the present invention;

[0035] Fig.12 It is the electron paramagnetic resonance spectrum of the PI / FU system of the present invention. DETAILED DESCRIPTION

[0036] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0037] It should be noted that the following detailed descriptions are exemplary and are intended to provide further explanation of the present invention. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present invention belongs.

[0038] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprising" and / or "including" are used in this specification, it indicates the presence of features, steps, operations and / or combinations thereof.

[0039] In the following embodiments:

[0040] 1. Collection and acquisition of real fresh urine FU:

[0041] The main components of fresh urine FU include: urea, NaCl, Na2SO4, KCl, MgCl2·6H2O, NaH2PO4·2H2O, CaCl2, trisodium citrate dihydrate and water.

[0042] The storage conditions of fresh urine FU are: storing urine FU at a temperature below 4°C and away from light; the time from collection to use of the fresh urine FU does not exceed 24 hours; the pH value of the fresh urine FU is about 6.

[0043] 2. Obtaining the real hydrolyzed urine HU:

[0044] Fresh urine usually begins to undergo significant urea hydrolysis reaction within 4-6 hours at room temperature (about 20-25°C), and after 24 hours, true completely hydrolyzed urine HU is obtained with a pH value of about 9. In addition, hydrolyzed simulated urine HU can also be obtained through laboratory configuration.

[0045] 3. Prepare simulated fresh urine FU and simulated hydrolyzed urine HU

[0046] The components and pH values ​​of the simulated fresh urine FU and simulated hydrolyzed urine HU used in the present invention are shown in Table 1. The substances in the table are dissolved in water with corresponding mass, and the volume is fixed to a 1000 mL volumetric flask after all the solids are dissolved. The urine is filtered by suction using a microporous filter membrane with a pore size of 0.45 μm to remove suspended impurities therein, and then stored at low temperature in a refrigerator at 4°C.

[0047] Table 1 Composition of urine

[0048]

[0049] 4. Prepare phosphate buffer (PB) solution (pH 6), called PB6

[0050] Use 0.2 mol / L NaOH solution to adjust 250 mL of 0.2 mol / L NaH2PO4 solution to obtain a phosphate buffer solution with a pH of 6, and adjust the volume to 1 L.

[0051] 5. Prepare phosphate buffer (PB) solution (pH 9), called PB9

[0052] Use 0.2 mol / L NaOH solution to adjust 250 mL of 0.2 mol / L NaH2PO4 solution to obtain a phosphate buffer solution with a pH of 9, and adjust the volume to 1 L.

[0053] Embodiment 1:

[0054] The present embodiment uses periodate PI to degrade and prepare the method of acetaminophen ACE in simulated fresh urine FU, which is achieved by the following steps:

[0055] (PI / simulated FU): At room temperature (25±1℃), the initial concentration of paracetamol ACE in simulated fresh urine FU was 5μmol / L, the system pH was 6, and the amount of periodate PI was 2mmol / L while ensuring that the total volume of the system was 100mL. After sufficient stirring, the reaction was terminated with sodium thiosulfate. The concentration C of paracetamol ACE in the system at different reaction times was detected, and the degradation of paracetamol ACE within 70 minutes was obtained, and the degradation rate was calculated.

[0056] Embodiment 2:

[0057] The method of using periodate PI to degrade the drug paracetamol ACE in real fresh urine FU in this embodiment is achieved by the following steps:

[0058] (PI / real FU): Under room temperature (25±1℃), the initial concentration of paracetamol ACE in real fresh urine FU is 5μmol / L, the pH of real fresh urine FU is 6.0, and the total volume of the system is 100mL. The amount of PI is 2mmol / L, and the reaction is terminated with sodium thiosulfate after sufficient stirring. The concentration C of drug paracetamol ACE in the system at different reaction times is detected, and the degradation of drug paracetamol ACE within 70 minutes is obtained.

[0059] Embodiment 3:

[0060] The method of using periodate PI to degrade the drug paracetamol ACE in PB6 in this embodiment is achieved by the following steps:

[0061] (PI / PB6): At room temperature (25±1℃), the initial concentration of paracetamol ACE in PB6 was 5μmol / L. Under the premise of ensuring that the total volume of the system was 100mL, the amount of PI was 2mmol / L. After sufficient stirring, the reaction was terminated with sodium thiosulfate. The concentration C of paracetamol ACE in the system at different reaction times was detected, and the degradation of paracetamol ACE within 70 minutes was obtained.

[0062] Embodiment 4:

[0063] The method of using periodate PI to degrade the drug paracetamol ACE in PB9 in this embodiment is achieved by the following steps:

[0064] (PI / PB9): At room temperature (25±1℃), the initial concentration of paracetamol ACE in PB9 was 5μmol / L. Under the premise of ensuring that the total volume of the system was 100mL, the amount of PI was 2mmol / L. After sufficient stirring, the reaction was terminated with sodium thiosulfate. The concentration C of paracetamol ACE in the system at different reaction times was detected, and the degradation of paracetamol ACE within 70 minutes was obtained.

[0065] Embodiment 5:

[0066] This embodiment uses periodate PI to degrade and prepare a method for simulating the hydrolysis of paracetamol ACE in urine HU, which is achieved by the following steps:

[0067] (PI / simulated HU): At room temperature (25±1℃), the initial concentration of paracetamol ACE in the simulated hydrolyzed urine HU was 5μmol / L, the system pH was 9, and the amount of periodate PI was 2mmol / L while ensuring that the total volume of the system was 100mL. After sufficient stirring, the reaction was terminated with sodium thiosulfate. The concentration C of paracetamol ACE in the system at different reaction times was detected, and the degradation of paracetamol ACE within 70 minutes was obtained, and the degradation rate was calculated.

[0068] Embodiment 6:

[0069] The method of utilizing periodate PI to degrade and truly hydrolyze the drug paracetamol ACE in urine HU in this embodiment is achieved by the following steps:

[0070] (PI / real HU): Under room temperature (25±1℃), the initial concentration C0 of paracetamol ACE in the real hydrolyzed urine HU is 5μmol / L, the system pH is 9.0, and the total volume of the system is 100mL. The PI dosage is 2mmol / L, and the reaction is terminated with sodium thiosulfate after sufficient stirring. The concentration C of the drug paracetamol ACE in the system at different reaction times is detected, and the degradation of the drug paracetamol ACE within 70 minutes is obtained.

[0071] Comparative Example 1:

[0072] (PI / water): At room temperature (25±1℃), the initial concentration of paracetamol ACE in pure water is 5μmol / L, the pH of the system is adjusted to 6, and the amount of PI is 2μmol / L while ensuring that the total volume of the system is 100mL. After sufficient stirring, the reaction is terminated with sodium thiosulfate. The concentration C of paracetamol ACE in the system at different reaction times is detected, and the degradation of paracetamol ACE within 70 minutes is obtained.

[0073] Comparative Example 2:

[0074] (H2O2 / real FU): At room temperature (25±1℃), the initial concentration of paracetamol ACE in real fresh urine FU is 5μmol / L, the system pH is 6, and the total volume of the system is 100mL. The amount of H2O2 is 2μmol / L, and the reaction is terminated with sodium thiosulfate after sufficient stirring. The concentration C of paracetamol ACE in the system at different reaction times is detected, and the degradation of paracetamol ACE within 70 minutes is obtained.

[0075] Comparative Example 3:

[0076] (PMS / real FU): At room temperature (25±1℃), the initial concentration of paracetamol ACE in real fresh urine FU is 5μmol / L, the system pH is 6, and the total volume of the system is 100mL. The amount of PMS is 2μmol / L, and the reaction is terminated with sodium thiosulfate after sufficient stirring. The concentration C of paracetamol ACE in the system at different reaction times is detected, and the degradation of paracetamol ACE within 70 minutes is obtained.

[0077] Comparative Example 4:

[0078] (PB6): At room temperature (25±1℃), the initial concentration of paracetamol ACE in PB6 was 5μmol / L. Under the premise of ensuring that the total volume of the system was 100mL, the reaction was terminated with sodium thiosulfate after sufficient stirring. The concentration C of paracetamol ACE in the system at different reaction times was detected, and the degradation of paracetamol ACE within 70 minutes was obtained.

[0079] Comparative Example 5:

[0080] (PB9): At room temperature (25±1℃), the initial concentration of paracetamol ACE in PB9 was 5μmol / L. Under the premise of ensuring that the total volume of the system was 100mL, the reaction was terminated with sodium thiosulfate after sufficient stirring. The concentration C of paracetamol ACE in the system at different reaction times was detected, and the degradation of paracetamol ACE within 70 minutes was obtained.

[0081] In addition: at room temperature (25±1°C), the initial concentration C0 of paracetamol ACE in real fresh urine FU is 5 μmol / L, the system pH is 6, and after sufficient stirring, the reaction is stopped by adding an equal amount of sodium thiosulfate in Example 2. The concentration C of paracetamol ACE in the system at different times is detected, and the degradation of paracetamol ACE within 70 minutes is obtained. The results show that the degradation rate is 0.08% in 70 minutes.

[0082] In addition: at room temperature (25±1°C), the initial concentration C0 of paracetamol ACE in simulated fresh urine FU was 5 μmol / L, the system pH was 6, and the mixture was stirred thoroughly and allowed to stand, and an equal amount of sodium thiosulfate in Example 2 was added to terminate the reaction. The concentration C of paracetamol ACE in the system at different times was detected, and the degradation of paracetamol ACE within 70 minutes was obtained. The results showed that the degradation rate was 0.06% in 70 minutes.

[0083] from Figure 1It can be seen that when the mixed solution was treated with PI / PB9, PB9, PB6, H2O2 / real FU, PI / real HU, PI / simulated HU, PMS / real FU and PI / water, the ACE degradation rates were 61.63%, 2.34%, 4.52%, 26.34%, 45.85%, 56.56%, 60.45% and 64.76%, respectively. When PI / PB6 system was used to degrade ACE, the degradation rate could reach 100.00%. It is worth noting that periodate PI has a significant degradation effect on paracetamol ACE in real fresh urine FU (system pH is 6), and the degradation rate can reach 100.00% within 70 minutes. Similarly, periodate PI also showed a good degradation effect on paracetamol ACE in simulated fresh urine FU (system pH is 6), and the degradation rate can also reach 100.00% in 50 minutes. This indicates that the PI / FU system can effectively treat paracetamol ACE in a real urine system and has good application prospects.

[0084] Embodiment 7:

[0085] In this example, the effect of the dosage of periodate PI on the degradation rate of paracetamol ACE was investigated.

[0086] like Figure 2 As shown, with Example 2 as a reference, the only difference is that the concentration of periodate PI in the mixed solution is changed to 0.5, 1, 2, 3, and 4 mmol / L, respectively. After 50 minutes, the degradation rates of paracetamol ACE are 52.94%, 69.63%, 100.00%, 100.00% and 100.00%, respectively.

[0087] Embodiment 8:

[0088] like Figure 3 As shown, with Example 2 as a reference, the only difference is that the concentration of paracetamol ACE in the mixed solution is changed to 3, 5, 7, and 9 mmol / L, respectively. After 50 minutes, the degradation rates of paracetamol ACE are 100.00%, 100.00%, 90.98% and 89.53%, respectively.

[0089] Embodiment 9:

[0090] like Figure 4 As shown, with Example 2 as a reference, the only difference is that the temperature of the mixed solution is changed, so that the reaction temperature is 15, 25, 35 and 40° C., respectively. After 50 minutes, the degradation rates of paracetamol ACE are 79.51%, 100.00%, 100.00% and 100.00%, respectively.

[0091] Embodiment 10:

[0092] like Figure 5As shown, with Example 2 as a reference, the only difference is that the pH value of the mixed solution is changed to 6, 7, 8 and 9, respectively. After 50 minutes, the degradation rate of paracetamol ACE decreases from 100.00% to 89.96%, 88.59%, 73.77% and 61.63%, respectively.

[0093] Embodiment 11:

[0094] like Figure 6 As shown, with Example 2 as a reference, the only difference is that the method of adding periodate PI is changed, so that equal amounts of periodate PI are added to the mixed solution in 1, 2, 3 and 4 times, respectively. After 50 minutes, the degradation rates of ACE are 100.00%, 82.95%, 80.85% and 82.33%, respectively.

[0095] Embodiment 12:

[0096] like Figure 7-Figure 8 As shown in the figure, at room temperature (25±1℃), paracetamol ACE and sodium periodate PI were added to fresh urine FU to ensure that their initial concentrations C0 were 5mmol / L and 2mmol / L respectively. Under the premise of ensuring that the total volume of the system was 100mL, different types of ions were added to verify their effects on ACE degradation. 44mmol / L Cl – 、15mmol / LSO4 2 – , and simultaneously add 44mmol / LCl – and 15mmol / L SO4 2– , respectively adding 4mmol / L Ca 2+ 、4mmol / L Mg 2+ , 250mmol / L urea and 2.7mmol / L sodium citrate ions had little effect on the degradation rate of ACE after 50 minutes.

[0097] Embodiment 13:

[0098] At room temperature (25±1℃), paracetamol ACE and sodium periodate PI were added to real fresh urine FU to ensure that their initial concentrations C0 were 5mmol / L and 2mmol / L, respectively. Under the premise of ensuring that the total volume of the system was 100mL, quenchers of different active substances were added, ascorbic acid 1, 5 and 10mmol / L (quencher of all ROS), histidine 0.05, 0.5 and 5mmol / L (corresponding to ROS 1 O2), phenol 0.05, 0.5 and 5 mmol / L (corresponding to ROS ·IO3 and ·IO4), nitro blue tetrazolium 0.02, 0.05 and 0.1 mmol / L (corresponding to ROS O2 ·-), tert-butyl alcohol 5, 10 and 15 mmol / L (corresponding to ROS is ·OH). Figure 9-11 As shown, the ROS in the PI / FU system are 1 O2 and OH play the most important role 1 O2.

[0099] Embodiment 14:

[0100] At room temperature (25±1℃), paracetamol ACE and sodium periodate PI were added to real fresh urine FU to ensure that their initial concentrations C0 were 5mmol / L and 2mmol / L respectively. Under the premise of ensuring that the total volume of the system was 100mL, the free radical scavenger 2,2,6,6-tetramethyl-4-piperidone (TEMP) was added, and the generation of free radicals was analyzed using an electron paramagnetic resonance spectrometer. Fig.12 As shown, the electron paramagnetic resonance spectrum shows 1 The signal of O2 further proves that the main ROS in the PI / FU system is 1 O2.

[0101] In summary, the present invention discloses a method for degrading paracetamol in fresh urine by using periodate, namely, a method for degrading paracetamol ACE in fresh urine FU by using periodate PI, wherein the method comprises the following steps: adding periodate PI to fresh urine FU contaminated with paracetamol ACE to be treated, and mixing the mixture uniformly to achieve rapid and efficient degradation of ACE; the PI / FU system established by the present invention can synergistically promote the generation of singlet oxygen and hydroxyl radicals, thereby achieving the purpose of rapid and efficient degradation of ACE; the present invention does not require additional energy supply, does not require any exogenous addition of any activator, greatly reduces the cost, has the advantages of efficient degradation of ACE, is environmentally friendly, and the like, and has broad application prospects in ensuring water ecological safety and safe resource utilization of urine.

[0102] At this point, those skilled in the art recognize that, although the embodiments of the present invention have been shown and described in detail herein, many other variations or modifications that conform to the principles of the present invention can still be directly determined or derived based on the contents disclosed in the present invention without departing from the spirit and scope of the present invention. Therefore, the scope of the present invention should be understood and recognized as covering all such other variations or modifications.

Claims

1. A method for degrading paracetamol in fresh urine using periodate, characterized in that: The method is: using periodate PI as an oxidant to directly degrade the drug paracetamol ACE in fresh urine FU at room temperature; specifically comprising the following steps: Step S1: collecting fresh urine FU, wherein the fresh urine FU contains the drug paracetamol ACE; Step S2: adding periodate PI to the fresh urine FU containing the drug paracetamol ACE in step S1, stirring and mixing evenly, and then obtaining urine in which the drug paracetamol ACE is degraded after the reaction is completed.

2. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The main components of the fresh urine FU include: urea, NaCl, Na2SO4, KCl, MgCl2·6H2O, NaH2PO4·2H2O, CaCl2, trisodium citrate dihydrate and water.

3. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The concentration of the drug paracetamol ACE in fresh urine FU is 3-9 mmol / L.

4. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The storage conditions of the fresh urine FU are: storing the urine FU in the dark at a temperature below 4° C.; the time from the collection of the fresh urine FU to its use shall not exceed 24 hours.

5. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The pH value of the fresh urine FU is 6-9.

6. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The periodate PI includes sodium periodate.

7. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The concentration of the periodate PI in fresh urine FU is 0.5-4 mmol / L.

8. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The stirring speed is 100-300 rpm.

9. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The reaction time is 30-90 min.

10. A method for degrading paracetamol in fresh urine using periodate as claimed in claim 1, characterized in that: The reaction temperature is 15-40°C.

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