D-chiro-inositol as insulin second messenger

Abstract

The invention relates to the technical field of application of feed additives, and provides d-chiro-inositol serving as a second messenger of insulin, and the d-chiro-inositol serving as an animal feed additive is used for improving animal ingestion and reducing animal blood sugar concentration. D-chiro-inositol is used as an additive in poultry breeding; the additive prepared from the d-chiro-inositol is one of powder, particles, capsules, gel or liquid; the addition amount of the additive in the feed is 3-80mg / kg of the additive; the addition amount of the additive in the feed is 7mg-15mg / kg of the additive; the d-chiro-inositol additive is used for promoting efficient uptake of poultry, and glucose is utilized; the d-chiro-inositol additive is mixed with corn, soybean meal, fish meal, stone powder or shell powder. According to the technical scheme, the problems that animals directly eat common feed at present and cannot eat a certain amount of feed again, glucose digested and taken by the animals is not well utilized, the blood sugar concentration is high, and the animals grow slowly are solved.

Description

Technical Field

[0001] The invention relates to the technical field of feed additive application, and in particular to d-chiro-inositol as a second messenger of insulin. Background Art

[0002] D-chiro-inositol, also known as d-allantoin, is an organic compound that occurs naturally in plant and animal cells. Its chemical formula is C6H 14 O5.

[0003] D-chiro-inositol is widely present in the body, especially in the nervous system and myocardium. It is an important secondary messenger molecule that can participate in a variety of biological metabolism and signal transduction processes. In the human body, the main functions of D-chiro-inositol include the following aspects: 1) promoting the absorption and utilization of glucose; 2) regulating the structure and function of cell membranes; 3) improving the function of the nervous system; 4) anti-oxidation effect.

[0004] With the development of science and technology, d-chiro-inositol is not limited to human application, but will also have more and more applications in other fields. The study on the antioxidant capacity of inositol and D-chiro-inositol in D-galactose-induced aging mice was recorded in the book "Study on the Antioxidant Effect of Inositol and D-chiro-inositol" (Zhang Zesheng, Liang Chen, Diao Zhuo, Xu Mengying). Methods: The aging mouse model was established by subcutaneous injection of D-galactose in the neck and back, and then 100, 200, and 400 mg / (kg·bw) of inositol and D-chiro-inositol were gavaged. After eight weeks of administration, the mice were killed to observe the effects on the activities of superoxide dismutase (SOD) and catalase (CAT) in serum, liver and brain tissue, the content of malondialdehyde (MDA) and the total antioxidant capacity (T-AOC). The results showed that compared with the model group, each dose group of inositol and D-chiro-inositol could increase the activities of SOD and CAT in serum and tissues to varying degrees, improve T-AOC, and reduce the content of MDA. This indicates that inositol and D-chiro-inositol can significantly improve the antioxidant capacity of D-galactose-induced aging mice by increasing the activity of antioxidant enzymes.

[0005] Currently, animals directly eat ordinary feed. After eating a certain amount of feed, they will not eat anymore. The glucose they digest and ingest is not well utilized, the blood sugar concentration is high, and the animals grow slowly. For this reason, we proposed d-chiro-inositol as the second messenger of insulin. Summary of the invention

[0006] The present invention proposes d-chiro-inositol as the second messenger of insulin, which solves the problem mentioned in the background technology that the existing animals directly eat ordinary feed, the animals will not eat after eating a certain amount of feed, the glucose digested and ingested is not well utilized, the blood sugar concentration is high, and the animals grow slowly.

[0007] The technical solution of the present invention is as follows: As the second messenger of insulin, d-chiro-inositol is used as an animal feed additive to increase animal feed intake and reduce animal blood sugar concentration.

[0008] As a further technical solution of the present invention, d-chiro-inositol is used as an additive in poultry farming.

[0009] As a further technical solution of the present invention, the additive made from d-chiro-inositol is one of powder, granules, capsules, gel or liquid.

[0010] As a further technical solution of the present invention, the amount of the additive added to the feed is 3mg-80mg additive / kg feed.

[0011] As a further technical solution of the present invention, the amount of the additive added to the feed is 7 mg-15 mg additive / kg feed.

[0012] As a further technical solution of the present invention, the d-chiro-inositol additive is used to promote poultry to efficiently ingest and utilize glucose.

[0013] As a further technical solution of the present invention, the d-chiro-inositol additive is uniformly mixed with one or more of corn, soybean meal, fish meal, stone powder, shell meal, meat and bone meal, vitamin premix and trace elements for use.

[0014] As a further technical solution of the present invention, when the additive is a gel or a liquid, the additive is fully mixed with the feed by using water accounting for one tenth of the total amount of the feed.

[0015] As a further technical solution of the present invention, d-chiro-inositol is used as an additive for feeding pets.

[0016] As a further technical solution of the present invention, d-chiro-inositol is used as an additive for feeding aquatic animals.

[0017] The working principle and beneficial effects of the present invention are: In the present invention, the use of d-chiro-inositol as an additive in animal feed can effectively promote the animal's feeding, better ingestion and utilization of glucose, and effectively control the blood sugar concentration level in the animal's body, so that the animal feeding effect is better, the poultry has a stronger antioxidant capacity, and the immunity is stronger. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0019] Figure 1 This is a comparative bar graph of the weight gain of chickens fed with the present invention within 6 weeks; Figure 2 A bar graph comparing the number of illnesses of chickens fed with the present invention within 6 weeks; Figure 3 A comparative bar graph of feed intake rates of chickens fed with the present invention for 6 weeks; Figure 4 A bar graph comparing blood sugar levels of chickens fed with the present invention for 6 weeks; Figure 5 This is a comparative bar graph of the weight gain of pigs fed with the present invention within 6 weeks; Figure 6 A bar chart comparing the number of illnesses of pigs fed with the present invention within 6 weeks; Figure 7 This is a bar graph comparing the feed intake rate of pigs fed with the present invention for 6 weeks; Figure 8 This is a bar graph comparing blood sugar levels in pigs fed with the present invention for 6 weeks. DETAILED DESCRIPTION

[0020] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0021] The embodiments of the present invention take chickens and pigs among poultry as examples. The following is the implementation of the specific embodiments. When the following implementation data are obtained, the corresponding conclusions are drawn. In order to avoid the influence of other factors, the temperature, humidity and other environmental conditions of the breeding are the same. The chickens and pigs are chickens and pigs of the same batch with similar growth status. The number of feedings and feeding time of the same species are controlled to be the same. The control of the above variables is to make the breeding of the embodiment more rigorous to avoid errors in subsequent results. It also includes some necessary experimental facilities to ensure the accuracy of the final results. The final result data are compared from two dimensions: weight and disease status from 0 to 6 weeks, where weight reflects the feed intake of chickens or pigs, that is, the greater the feed intake, the heavier the weight, and the disease status is used to reflect the immunity of chickens or pigs, and the feed intake is counted at the same time; in the embodiment, the breeding team is composed of experienced breeders who have been raising poultry for more than 5 years to feed the poultry. Example

[0022] In this embodiment, take chicken farming as an example: In this embodiment, the d-chiro-inositol additive is a powder, which is divided into the following 6 groups, each group has 20 chickens, 10 males and 10 females, and the amount of feed for a single chicken per day is unlimited. After the chickens finish eating, the remaining feed is cleaned up and the average feed intake of the chickens is counted; (1) Add d-chiro-inositol to feed at a ratio of 3 mg additive / kg feed and mix thoroughly. Feed the feed to chickens for 6 weeks. During this period, weigh the chickens regularly, record the number of times the chickens get sick, and count the feed intake and blood glucose concentration of the chickens. (2) Add d-chiro-inositol to the feed at a ratio of 80 mg additive / kg feed, mix thoroughly, and feed the chickens for 6 weeks. During this period, weigh the chickens regularly, record the number of times the chickens get sick, and count the feed intake and blood glucose concentration of the chickens. (3) Add d-chiro-inositol to the feed at a ratio of 7 mg additive / kg feed and mix thoroughly. Feed the feed to the chickens for 6 weeks. During this period, weigh the chickens regularly, record the number of times the chickens get sick, and count the feed intake and blood glucose concentration of the chickens. (4) Add d-chiro-inositol to the feed at a ratio of 15 mg additive / kg feed and mix thoroughly. Feed the feed to the chickens for 6 weeks. During this period, weigh the chickens regularly, record the number of times the chickens get sick, and count the feed intake and blood glucose concentration of the chickens. (5) Add d-chiro-inositol to the feed at a ratio of 25 mg additive / kg feed and mix thoroughly. Feed the feed to the chickens for 6 weeks. During this period, weigh the chickens regularly, record the number of times the chickens get sick, and count the feed intake and blood glucose concentration of the chickens. (6) D-chiro-inositol was added to the feed at a ratio of 40 mg additive / kg feed and mixed thoroughly. The feed was then fed to the chickens for 6 weeks. The chickens were weighed regularly during this period, the number of times the chickens got sick was recorded, and the feed intake and blood glucose concentration of the chickens were counted.

[0023] Comparative Example 1 This comparative example is compared with Example 1. The difference from any group in Example 1 is that no d-chiro-inositol additive is added to the feed, and the other variables are the same. The number of chickens in this comparative example is 20.

[0024] It should be noted that there is no limit to the amount of feed a single chicken can receive per day. The remaining feed is cleaned up after the chicken has eaten all the food. The uneaten part is cleared out, and the excess is used to test whether the additives can promote the chicken's appetite, so as to verify the effect of the additives in promoting feeding of poultry.

[0025] The chickens in the above embodiment and the comparative example were all raised for 3 months, and the average weight, number of sick chickens, weight compliance and other parameters of the chickens were compared to obtain the following table: On the basis of the above table, the feed intake of the chickens was counted, and the average increase in feed intake relative to comparative example 1 after the additive was added to the feed was calculated, wherein the grams were rounded off, and the following table was finally obtained: Based on regular testing of the blood glucose concentration of chickens, the following table data was obtained:

[0026] It can be seen that by adding d-chiro-inositol as an additive into the feed, compared with normal feeding, in a 6-week period of observation, the average weight of chickens exceeded 713.75%-772.82%, relative to 547.01% in the control group, the feed intake rate was better, the disease rate was between 0.00%-25%, relative to 55.00% in the control group, which can greatly reduce the disease rate. At the same time, it can effectively increase the feed intake rate by 11.86%-16.95%, and the blood sugar concentration was also significantly reduced, generally reduced by more than 15%.

[0027] Example 2 In this embodiment, take pig farming as an example: In this embodiment, the d-chiro-inositol additive is in the form of powder, and is divided into the following 6 groups, each group has 20 pigs, 10 males and 10 females, and the amount of feed for a single pig per day is unlimited, and the remaining feed is cleaned up after the pigs have eaten; (1) Add d-chiro-inositol to feed at a ratio of 3 mg additive / kg feed, mix thoroughly, and feed the feed to pigs for 6 weeks. During this period, the pigs were weighed regularly, the number of times they got sick was checked, and the average feed intake and blood glucose concentration of the pigs were calculated. (2) Add d-chiro-inositol to the feed at a ratio of 80 mg additive / kg feed, mix thoroughly, and feed the feed to pigs for 6 weeks. During this period, the pigs were weighed regularly, the number of times they got sick was checked, and the average feed intake and blood glucose concentration of the pigs were calculated. (3) Add d-chiro-inositol to the feed at a ratio of 7 mg additive / kg feed, mix thoroughly, and feed the feed to pigs for 6 weeks. During this period, the pigs were weighed regularly, the number of times they got sick was checked, and the average feed intake and blood glucose concentration of the pigs were calculated. (4) Add d-chiro-inositol to the feed at a ratio of 15 mg additive / kg feed, mix thoroughly, and feed the feed to pigs for 6 weeks. During this period, the pigs were weighed regularly, the number of times the pigs got sick was checked, and the average feed intake and blood glucose concentration of the pigs were calculated; (5) Add d-chiro-inositol to the feed at a ratio of 25 mg additive / kg feed, mix thoroughly, and feed the feed to pigs for 6 weeks. During this period, the pigs were weighed regularly, the number of times the pigs got sick was checked, and the average feed intake and blood glucose concentration of the pigs were calculated; (6) D-chiro-inositol was added to the feed at a ratio of 40 mg additive / kg feed and mixed thoroughly. The feed was then fed to pigs for 6 weeks. The pigs were weighed regularly during this period, the number of times they were sick was checked, and the average feed intake and blood glucose concentration of the pigs were calculated.

[0028] Comparative Example 2 This comparative example is compared with Example 1. The difference from any group in Example 1 is that no d-chiro-inositol additive is added to the feed, and the other variables are the same. The number of pigs in this comparative example is 20.

[0029] It should be noted that there is no limit to the amount of feed a single pig can eat per day. The remaining feed is cleaned up after the pig has eaten it. The uneaten part is cleared out, and the excess is used to test whether the additives have a promoting effect on the pig's appetite.

[0030] This comparative example is compared with Example 2. The difference from Example 2 is that no d-chiro-inositol additive is added, and the other variables are the same.

[0031] The pigs in the above embodiment and comparative example were all raised for 3 months, and the average weight, number of sick pigs, weight compliance and other parameters of the pigs were compared to provide a reference for the feeding effect of the additive, wherein the pigs were raised in the same batch, and the following table was finally obtained:

[0032] On the basis of the above table, the feed intake of the pigs was counted, and the average increase in feed intake relative to comparative example 1 after the additive was added to the feed was calculated, wherein the comparative example was a normal breeding, and the difference between the embodiment grouping and the comparative example was that the feed in the embodiment was added with d-chiro-inositol additive, and the data finally obtained were collected and sorted, and finally the following table was obtained:

[0033] Based on regular testing of pigs' blood sugar concentrations, the following table data was obtained:

[0034] It can be seen that in pig farming, after 6 weeks, the average weight of the pigs exceeded 15.00%-22.88%, which is 11.29% in the control group, and the weight gain was faster. The disease rate was between 0.00%-5%, which is 20.00% in the control group, which can greatly reduce the disease rate. At the same time, the addition of additives increased the feed intake rate by 10.71%-17.86%, and the feed intake rate was better. The blood sugar concentration was also significantly reduced, basically reduced by more than 35%.

[0035] In summary, the use of the d-chiro-inositol of the present invention as an additive added into feed can greatly improve the feeding rate of poultry, and at the same time can effectively control the blood sugar concentration of poultry, and can play a better role in poultry breeding.

[0036] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. D-chiro-inositol as a second messenger of insulin, characterized in that D-chiro-inositol is used as an animal feed additive to increase animal feed intake and reduce animal blood sugar concentration.

2. The use of d-chiro-inositol in animal feed according to claim 1, characterized in that D-Chiro-inositol is used as a supplement in poultry farming.

3. The use of d-chiro-inositol in animal feed according to claim 1, characterized in that The supplement made from d-chiro-inositol is one of powder, granules, capsules, gel or liquid.

4. The use of d-chiro-inositol in animal feed according to claim 3 or 1, characterized in that, The amount of additive added in the feed is 3mg-80mg additive / kg feed.

5. The use of d-chiro-inositol in animal feed according to claim 4, characterized in that The amount of additive added in the feed is 7mg-15mg additive / kg feed.

6. The use of d-chiro-inositol in animal feed according to claim 1, characterized in that: The d-chiro-inositol additive is used for promoting poultry to efficiently ingest and utilize glucose.

7. The use of d-chiro-inositol in animal feed according to claim 1, characterized in that: The d-chiro-inositol additive is uniformly mixed with one or more of corn, soybean meal, fish meal, stone meal, shell meal, meat and bone meal, vitamin premix and trace elements for use.

8. The use of d-chiro-inositol in animal feed according to claim 3, characterized in that: When the additive is one of a gel or a liquid, the additive is fully mixed with the feed by using water accounting for one tenth of the total amount of the feed.

9. The use of d-chiro-inositol in animal feed according to claim 3, characterized in that: D-chiro-inositol is used as a supplement for feeding pets.

10. The use of d-chiro-inositol in animal feed according to claim 1, characterized in that: D-chiro-inositol is used as a supplement for feeding aquatic animals.

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