Product for reducing blood fat and preparation method thereof

Abstract

The invention relates to a product for reducing blood fat and a preparation method thereof. Firstly, the preparation method of the natto freeze-dried powder is optimized, specifically, soybeans are subjected to solid-state fermentation through a compound bacteria solution composed of bacillus subtilis, lactobacillus plantarum and bifidobacterium adolescentis, and the enzyme activity of nattokinase in the natto freeze-dried powder is effectively improved through the improvement. The natto freeze-dried powder of high-activity nattokinase prepared in the invention is used as a main raw material, and is further scientifically compounded with natural nutritional essences such as EGCG, desert cistanche, dendrobium officinale, gastrodia elata, Chinese yam, sea buckthorn fruit and the like, so that the prepared product is beneficial to maintaining the health level of blood fat; the multiple functional components can synergistically achieve the effects of repairing vascular endothelium, dissolving thrombus, clearing away blood vessel garbage, improving blood circulation and the like, no adverse reaction exists, and the traditional Chinese medicine composition has wide market application prospects.

Description

Technical Field

[0001] The invention belongs to the technical field of natto fermentation and food processing, and particularly relates to a product for lowering blood lipids and a preparation method thereof. Background Art

[0002] In recent years, with the continuous improvement of people's living standards, the continuous extension of average life expectancy and the sharp increase in the elderly population, cardiovascular and cerebrovascular diseases have become the number one killer of national health. According to data released in 2021: the current number of cardiovascular disease patients in my country is as high as 330 million, and the annual treatment funds for cardiovascular and cerebrovascular diseases are more than 300 billion.

[0003] Among the "three highs", high blood pressure and high blood sugar are more likely to attract people's attention, while high blood lipids caused by high cholesterol are easily ignored because they often do not cause too many symptoms in the early and middle stages. According to statistics, at least 1 / 3 of adults in my country have abnormal blood lipids. High blood lipids are harmful to the body in a hidden, gradual, progressive and systemic way, which can cause blood clots and lead to various cardiovascular diseases, such as coronary heart disease and cerebral infarction.

[0004] Currently, the treatment of hyperlipidemia is mainly through two approaches: drug therapy and non-drug therapy. Medical research has shown that long-term use of powerful lipid-lowering drugs can cause damage to the body's digestive system, endocrine system, liver and kidneys, and have serious side effects.

[0005] The main cause of thrombosis is excessive fibrin in the blood, which blocks the flow of blood in the blood vessels. Nattokinase is an alkaline serine protease naturally secreted by Bacillus subtilis during the fermentation process. It has strong fibrinolytic activity and a strong effect on thrombolysis. Therefore, Nattokinase helps improve blood circulation and reduce blood viscosity. It has the advantages of no side effects, low cost and long half-life, and has broad market application prospects and strong market competitiveness.

[0006] However, the production method of nattokinase in the prior art is usually to directly use Bacillus natto for fermentation, and the nattokinase obtained by fermentation has low activity and low yield, which is difficult to meet market demand. In addition, most of the lipid-lowering effects of the current lipid-regulating health products on the market are poor, and it is still urgent to develop products with high safety and good effects for reducing blood lipids. Summary of the invention

[0007] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a product for lowering blood lipids and a preparation method thereof. The product can effectively lower blood lipids, and multiple functional ingredients can synergistically achieve the effects of repairing vascular endothelium, dissolving thrombus, removing vascular waste, improving blood circulation, and activating cell vitality, and the product is safe and healthy without any adverse reactions.

[0008] To achieve the above object, the technical solution adopted by the present invention is: In a first aspect, the present invention provides a product for lowering blood lipids, characterized in that it comprises the following components in parts by weight: 100-200 parts of freeze-dried natto powder, 50-100 parts of yeast, 50-100 parts of epigallocatechin gallate (EGCG), 50-100 parts of desert cistanche, 50-100 parts of dendrobium officinale powder, 50-100 parts of gastrodia powder, 50-100 parts of yam powder, 50-100 parts of sea buckthorn fruit powder, and 5-10 parts of red yeast rice powder.

[0009] Among them, nattokinase in natto freeze-dried powder has a strong effect in dissolving blood clots and is known as the "blood lipid scavenger."

[0010] Yeast contains a variety of bioactive substances such as β-glucan, which helps to reduce the absorption of ingested fat and improve blood lipids.

[0011] EGCG helps repair the vascular endothelium, maintain the smoothness and flatness of blood vessels, promotes vasoconstriction and relaxation, and has anti-atherosclerosis, anti-thrombosis, and anti-angiogenesis effects.

[0012] Cistanche can effectively regulate the blood circulation system. Its most significant effect is that it can effectively protect ischemic myocardium, dilate peripheral blood vessels, lower blood lipids, resist thrombosis, resist fatty liver, and lower blood pressure. Gastrodia powder can increase cerebral blood flow and reduce cerebral vascular resistance. The combination of the two can improve the blood circulation of the peripheral blood vessels of the heart and brain.

[0013] Dendrobium candidum can improve blood lipid levels, remove toxins accumulated in blood vessels, restore elasticity to hardened blood vessels, prevent blood vessel rupture, dredge blood vessels, and purify the blood.

[0014] The active ingredient of seabuckthorn, superoxide dismutase (SOD), has the function of removing free radicals in the human body, which can prevent cells from being damaged by peroxides and thus protect cells.

[0015] Red yeast rice powder produces natural statins that can inhibit the biosynthesis of cholesterol. It also contains a variety of amino acids, unsaturated fatty acids and other active substances, which have significant effects on lowering human cholesterol, regulating blood lipids, lowering blood pressure and promoting cardiovascular health.

[0016] In a second aspect, the present invention provides a method for preparing freeze-dried natto powder, comprising the following steps: S1. Wash, soak, drain, and steam to sterilize the soybeans; S2. Inoculate the sterilized and cooled soybeans with a complex bacterial solution of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis, stir evenly, and ferment at a constant temperature of 35-40 ℃ for 25-35 hours; S3. After the fermentation is completed, the fermentation product is allowed to stand at 4°C for 12-15 hours, and then freeze-dried and crushed to obtain natto freeze-dried powder; Wherein, the volume ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid is 3-5:1:0.5-1.5.

[0017] Preferably, in step S2, the deposit number of the Bacillus subtilis is CGMCC No.21354, the deposit number of the Lactobacillus plantarum is CGMCC No.1.1856, and the deposit number of the Bifidobacterium adolescentis is CGMCC No.1.2190.

[0018] Preferably, in step S2, the fermentation is carried out at 37° C. for 30 hours.

[0019] Preferably, the product comprises the following components in parts by weight: 150 parts of freeze-dried natto powder, 80 parts of yeast, 60 parts of epigallocatechin gallate (EGCG), 75 parts of desert cistanche, 60 parts of dendrobium officinale powder, 60 parts of gastrodia powder, 70 parts of yam powder, 80 parts of sea buckthorn fruit powder, and 7 parts of red yeast rice powder.

[0020] Preferably, the soaking time in step S1 is 12-16 hours.

[0021] Preferably, in step S2, the composite bacterial liquid is inoculated at an inoculation amount of 2-5% v / w.

[0022] Preferably, in step S1, the steam sterilization is performed by steaming in a high pressure steam sterilizer for 30 to 40 minutes.

[0023] Preferably, in step S1, a nutrient supplement liquid is added to the soybeans after draining, the amount of the nutrient supplement liquid added is 10-15% of the mass of the soybeans, and the nutrient supplement liquid contains: 1 g / L MgSO4·7H2O, 10 g / L sucrose and 5 g / L soy peptone.

[0024] In a third aspect, the present invention further provides a method for preparing the aforementioned product for lowering blood lipids, the preparation method comprising: weighing various raw materials according to the formula, mixing, sterilizing, and packaging.

[0025] In a fourth aspect, the present invention also provides the use of the aforementioned product in the preparation of a product for lowering blood lipids.

[0026] Compared with the prior art, the present invention has the following beneficial effects: 1) This application optimizes the preparation method of freeze-dried natto powder. The inventors obtained a composite bacterial liquid composed of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis through multiple rounds of screening. Solid-state fermentation of soybeans with the composite bacterial liquid can effectively improve the enzyme activity of nattokinase in freeze-dried natto powder, and the active substances produced after mixed bacterial fermentation also have a good lipid-lowering effect; 2) In order to promote strain growth and shorten the fermentation cycle, the present invention also adds a nutrient supplement to the fermentation substrate, soybeans. The nutrient supplement has a reasonable ratio and can further improve the enzyme activity of nattokinase in natto freeze-dried powder; 3) The natto freeze-dried powder with high activity nattokinase prepared in the present invention is used as the main raw material, and is further scientifically compounded with yeast, epigallocatechin gallate (EGCG), desert cistanche, dendrobium officinale powder, gastrodia powder, yam powder, seabuckthorn fruit powder, and red yeast rice powder. The prepared product helps to maintain a healthy level of blood lipids, and the multiple functional ingredients can synergistically achieve the effects of repairing vascular endothelium, dissolving thrombus, clearing vascular garbage, improving blood circulation, etc., without any adverse reactions, and has broad market application prospects and great economic value. DETAILED DESCRIPTION

[0027] The embodiments described below are only a part of the embodiments of the present application, rather than all the embodiments. The embodiments of the present application are used to illustrate the present invention, rather than to limit the present invention. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative work are within the scope of protection of the present application.

[0028] The experimental methods in the following examples without specifying specific conditions are usually carried out under conventional conditions or conditions recommended by the manufacturers. The materials and reagents used can be obtained from commercial sources unless otherwise specified.

[0029] The strains used in the present invention include Bacillus subtilis with a preservation number of CGMCC No. 21354, Lactobacillus plantarum with a preservation number of CGMCC No. 1.1856, Bifidobacterium adolescentis with a preservation number of CGMCC No. 1.2190, and Lactobacillus plantarum with a preservation number of CGMCC No. 1.568, and the live bacterial concentration of each strain in the composite bacterial solution is 1×10 8 CFU / ml.

[0030] Example 1: A product for lowering blood lipids, comprising: 150 parts of natto freeze-dried powder, 80 parts of yeast, 60 parts of epigallocatechin gallate (EGCG), 75 parts of desert cistanche, 60 parts of dendrobium officinale powder, 60 parts of gastrodia powder, 70 parts of yam powder, 80 parts of sea buckthorn fruit powder, and 7 parts of red yeast rice powder; The preparation method of the natto freeze-dried powder includes: 1) Select high-quality soybeans with full grains, no mold, and no insects. Wash the soybeans three times and soak them for 15 hours. After soaking, the beans are full and have no hard core. Drain the soybeans and add nutrient supplement liquid. The amount of nutrient supplement liquid added is 12% of the mass of soybeans. The nutrient supplement liquid contains: 1g / L MgSO4·7H2O, 10g / L sucrose and 5g / L soy peptone, and the pH is 7.2. Mix the nutrient supplement liquid and soybeans evenly and steam them in a steam sterilizer for 35 minutes for sterilization; 2) After sterilization, cool to about 37°C, inoculate the soybeans with a composite bacterial solution consisting of activated Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis, stir evenly, and ferment at 37°C for 30 hours; 3) After the fermentation is completed, the fermentation product is allowed to stand at 4°C for 14 hours, and then the fermentation product is placed in a vacuum freeze dryer under sterile conditions for freeze-drying. After crushing, natto freeze-dried powder is obtained.

[0031] Among them, the volume ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid is 4:1:1, and the composite bacterial liquid is inoculated at an inoculation amount of 4% (v / w); the preservation number of Bacillus subtilis is CGMCC No.21354, the preservation number of Lactobacillus plantarum is CGMCC No.1.1856, and the preservation number of Bifidobacterium adolescentis is CGMCC No.1.2190; the pulverization is carried out by ultrafine pulverization for 15 minutes.

[0032] Example 2: A product for lowering blood lipids, comprising: 150 parts of freeze-dried natto powder, 80 parts of yeast, 60 parts of epigallocatechin gallate (EGCG), 75 parts of desert cistanche, 60 parts of dendrobium officinale powder, 60 parts of gastrodia powder, 70 parts of yam powder, 80 parts of sea buckthorn fruit powder, and 7 parts of red yeast rice powder; The preparation method of the natto freeze-dried powder includes: 1) Select high-quality soybeans with full grains, no mold, and no insects. Wash the soybeans three times and soak them for 15 hours. After soaking, the beans are full and have no hard core. Drain the soybeans and add nutrient supplement liquid. The amount of nutrient supplement liquid added is 12% of the mass of soybeans. The nutrient supplement liquid contains: 1g / L MgSO4·7H2O, 10g / L sucrose and 5g / L soy peptone, and the pH is 7.2. Mix the nutrient supplement liquid and soybeans evenly and steam them in a steam sterilizer for 35 minutes for sterilization; 2) After sterilization, cool to about 37°C, inoculate the soybeans with a composite bacterial solution consisting of activated Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis, stir evenly, and ferment at 37°C for 30 hours; 3) After the fermentation is completed, the fermentation product is allowed to stand at 4°C for 14 hours, and then the fermentation product is placed in a vacuum freeze dryer under sterile conditions for freeze-drying. After crushing, natto freeze-dried powder is obtained.

[0033] Among them, the volume ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid is 5:1:0.5, and the composite bacterial liquid is inoculated at an inoculation amount of 4% (v / w); the preservation number of Bacillus subtilis is CGMCC No.21354, the preservation number of Lactobacillus plantarum is CGMCC No.1.1856, and the preservation number of Bifidobacterium adolescentis is CGMCC No.1.2190; the pulverization is carried out by ultrafine pulverization for 15 minutes.

[0034] Example 3: A product for lowering blood lipids, comprising: 150 parts of freeze-dried natto powder, 80 parts of yeast, 60 parts of epigallocatechin gallate (EGCG), 75 parts of desert cistanche, 60 parts of dendrobium officinale powder, 60 parts of gastrodia powder, 70 parts of yam powder, 80 parts of sea buckthorn fruit powder, and 7 parts of red yeast rice powder; The preparation method of the natto freeze-dried powder includes: 1) Select high-quality soybeans with full grains, no mold, and no insects. Wash the soybeans three times and soak them for 15 hours. After soaking, the beans are full and have no hard core. Drain the soybeans and add nutrient supplement liquid. The amount of nutrient supplement liquid added is 12% of the mass of soybeans. The nutrient supplement liquid contains: 1g / L MgSO4·7H2O, 10g / L sucrose and 5g / L soy peptone, and the pH is 7.2. Mix the nutrient supplement liquid and soybeans evenly and steam them in a steam sterilizer for 35 minutes for sterilization; 2) After sterilization, cool to about 37°C, inoculate the soybeans with a composite bacterial solution consisting of activated Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis, stir evenly, and ferment at 37°C for 30 hours; 3) After the fermentation is completed, the fermentation product is allowed to stand at 4°C for 14 hours, and then the fermentation product is placed in a vacuum freeze dryer under sterile conditions for freeze-drying. After crushing, natto freeze-dried powder is obtained.

[0035] Among them, the volume ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid is 3:1:1.5, and the composite bacterial liquid is inoculated at an inoculation amount of 4% (v / w); the preservation number of Bacillus subtilis is CGMCC No.21354, the preservation number of Lactobacillus plantarum is CGMCC No.1.1856, and the preservation number of Bifidobacterium adolescentis is CGMCC No.1.2190; the pulverization is carried out by ultrafine pulverization for 15 minutes.

[0036] Comparative Example 1: Compared with Example 1, the only difference is that the volume ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid is 2:1:1, and the rest is the same as Example 1.

[0037] Comparative Example 2: Compared with Example 1, the only difference is that the volume ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid is 4:1:2, and the rest is the same as Example 1.

[0038] Comparative Example 3: Compared with Example 1, the difference is that in step 2), only an equal amount of Bacillus subtilis with a preservation number of CGMCC No. 21354 is inoculated on the soybean instead of the composite bacterial solution (that is, the amount of Lactobacillus plantarum and Bifidobacterium adolescentis missing in the composite bacterial solution is supplemented by Bacillus subtilis), and the rest is the same as Example 1.

[0039] Comparative Example 4: Compared with Example 1, the only difference is that an equal amount of Lactobacillus plantarum with a preservation number of CGMCC No. 1.568 is used to replace the Lactobacillus plantarum with a preservation number of CGMCC No. 1.1856 in the composite bacterial liquid, and the rest is the same as Example 1.

[0040] Experiment 1 Determination of nattokinase (NK) activity in natto freeze-dried powder by agarose-fibrin plate method: The agarose-fibrin plate method is based on the principle that nattokinase hydrolyzes fibrin in the fibrin plate to form a transparent circle, and the area of ​​the transparent circle is used to calculate the fibrinolytic activity of nattokinase. This method is currently the most commonly used method for determining the thrombolytic activity of fibrinolytic enzyme, and is also one of the earliest methods used to determine the thrombolytic activity of nattokinase.

[0041] Experimental method: 1) Prepare agarose-fibrin plate; 2) Use urokinase standard solution to draw standard curve; 3) Determination of nattokinase activity in sample: Mix the freshly prepared natto freeze-dried powder samples in Examples 1-3 and Comparative Examples 1-4 in physiological saline at a mass ratio of 1:10, mix well, let stand at 4°C for 4 hours, centrifuge and take the supernatant; dilute the supernatant 5 times with physiological saline to obtain the crude enzyme solution of nattokinase to be tested. Take 10μL of the crude enzyme solution of nattokinase to be tested and spot it on the agarose-fibrin plate, react in a constant temperature incubator at 37°C for 18 hours, measure the vertical diameter of the dissolution circle with a vernier caliper, calculate the area of ​​the dissolution circle, and calculate the nattokinase activity according to the linear regression formula of the standard curve (Note: Each sample to be tested is repeated 2 times, and the average value is taken as the test result after the determination).

[0042] The test results are as follows: Table 1 Results of determination of nattokinase activity in natto freeze-dried powder Group Nattokinase activity in natto freeze-dried powder (IU / g) Example 1 26453.01 Example 2 23976.84 Example 3 25069.59 Comparative Example 1 13842.66 Comparative Example 2 15035.92 Comparative Example 3 9874.13 Comparative Example 4 20631.28 As can be seen from the results in Table 1: The results of the comparative example and comparative example 3 show that the solid-state fermentation of soybeans using a composite bacterial solution composed of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis can significantly improve the nattokinase activity in natto freeze-dried powder compared with solid-state fermentation using only Bacillus subtilis. The results of the comparative example and comparative examples 1-2 show that the ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacteria also has a great influence on the nattokinase activity. The results of the comparative example and comparative example 4 show that different strains of Lactobacillus plantarum also have a certain influence on the nattokinase activity in natto freeze-dried powder.

[0043] Experiment 2 Determination of blood lipid lowering ability Experimental animals: Healthy male SD rats, weighing (200±20) g, were randomly divided into 9 groups, 10 rats / group, namely normal control group, model control group, embodiment group (embodiments 1-3), comparative example group (comparative example 1-4), and adaptively fed for 7 days before the experiment.

[0044] Kits: total cholesterol (TC) detection kit, triglyceride (TG) detection kit, low-density lipoprotein cholesterol (LDL-C) detection kit; perform the test according to the instructions of the corresponding kit.

[0045] Feeding conditions: Except for the normal control group, the rats in other groups were fed with high-fat diet for 4 consecutive weeks to form hyperlipidemia model animals; the normal control group was fed with ordinary diet.

[0046] Experimental method: During the experiment, the products prepared in Examples 1-3 and Comparative Examples 1-4 were respectively configured into aqueous solutions with physiological saline, and given to animals by gavage (1 mL / 100 g). The normal control group and the model control group were gavaged with the same volume of physiological saline every day. Among them, the gavage dose of the product was 1 g / kg body weight, and each group was gavaged once a day at a fixed time. During the experiment, the rats in each group were free to eat and drink. After continuous gavage for 4 weeks, blood was collected, and serum was obtained by centrifugation. The contents of TC, TG and LDL-C in the serum were determined according to the kit.

[0047] Experimental data processing: SPSS statistical software was used for variance analysis.

[0048] The test results are as follows: Table 2 Effects of the products in this application on hyperlipidemic rats Group TC (mmol / L) TG (mmol / L) LDL (mmol / L) Normal control group 1.38±0.30 0.70±0.18 0.38±0.07 Model control group <![CDATA[2.87±0.43 ## ]]> <![CDATA[2.23±0.39 ## ]]> <![CDATA[0.96±0.13 ## ]]> Example 1 <![CDATA[1.50±0.25 ** ]]> <![CDATA[0.91±0.27 ** ]]> <![CDATA[0.49±0.20 ** ]]> Example 2 <![CDATA[1.71±0.36 ** ]]> <![CDATA[1.14±0.43 ** ]]> <![CDATA[0.53±0.18 ** ]]> Example 3 <![CDATA[1.64±0.28 ** ]]> <![CDATA[1.09±0.31 ** ]]> <![CDATA[0.56±0.25 ** ]]> Comparative Example 1 <![CDATA[2.03±0.39 * ]]> <![CDATA[1.38±0.29 ** ]]> <![CDATA[0.72±0.17 * ]]> Comparative Example 2 <![CDATA[1.95±0.41 ** ]]> <![CDATA[1.35±0.32 ** ]]> <![CDATA[0.70±0.19 * ]]> Comparative Example 3 <![CDATA[2.16±0.27 * ]]> <![CDATA[1.57±0.44 * ]]> <![CDATA[0.84±0.22 * ]]> Comparative Example 4 <![CDATA[1.89±0.31 ** ]]> <![CDATA[1.22±0.37 ** ]]> <![CDATA[0.65±0.14 ** ]]> Note: Compared with the normal control group, ## P<0.01; compared with the model control group, * P<0.05, ** P<0.01 As shown in Table 2, compared with the normal control group, the serum TC, TG, and LDL-C levels of the model control group were significantly increased (P < 0.01), indicating that the hyperlipidemic rat model was successfully established. Comparing the embodiment and the comparative example with the model control group, it is shown that the lipid-lowering product composed of natto freeze-dried powder, yeast, epigallocatechin gallate (EGCG), desert cistanche, dendrobium officinale powder, gastrodia powder, yam powder, seabuckthorn fruit powder and red yeast rice powder can significantly reduce the serum TC, TG, and LDL-C levels of hyperlipidemic rats, that is, the product provided by the present invention has a good lipid-lowering effect. Comparing the embodiment with comparative examples 1-2, it is shown that the ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid has a great influence on the lipid-lowering function of the product; comparing the embodiment with comparative example 3, it is shown that mixed fermentation is significantly better than single fermentation of Bacillus subtilis. This may be because solid-state fermentation of soybeans with the composite bacterial liquid can effectively increase the content of nattokinase in natto freeze-dried powder, and the active substances produced after mixed fermentation also have a good lipid-lowering effect.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A product for lowering blood lipids, characterized in that: The product comprises the following components in parts by weight: 100-200 parts of freeze-dried natto powder, 50-100 parts of yeast, 50-100 parts of epigallocatechin gallate (EGCG), 50-100 parts of desert cistanche, 50-100 parts of dendrobium officinale powder, 50-100 parts of gastrodia powder, 50-100 parts of yam powder, 50-100 parts of sea buckthorn fruit powder, and 5-10 parts of red yeast rice powder; The preparation method of the natto freeze-dried powder includes: S1. Wash, soak, drain, and steam to sterilize the soybeans; S2. Inoculate the sterilized and cooled soybeans with a complex bacterial solution of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis, stir evenly, and ferment at a constant temperature of 35-40 ℃ for 25-35 hours; S3. After the fermentation is completed, the fermentation product is allowed to stand at 4°C for 12-15 hours, and then freeze-dried and crushed to obtain natto freeze-dried powder; Wherein, the volume ratio of Bacillus subtilis, Lactobacillus plantarum and Bifidobacterium adolescentis in the composite bacterial liquid is 3-5:1:0.5-1.

5.

2. The product for lowering blood lipids as claimed in claim 1, wherein: The Bacillus subtilis in step S2 has a deposit number of CGMCC No. 21354, the Lactobacillus plantarum has a deposit number of CGMCC No. 1.1856, and the Bifidobacterium adolescentis has a deposit number of CGMCC No. 1.2190.

3. The product for lowering blood lipids as claimed in claim 1, wherein: In step S2, the fermentation is carried out at 37° C. for 30 hours.

4. The product for lowering blood lipids as claimed in any one of claims 1 to 3, comprising the following components in parts by weight: 150 parts of freeze-dried natto powder, 80 parts of yeast, 60 parts of epigallocatechin gallate (EGCG), 75 parts of desert cistanche, 60 parts of dendrobium officinale powder, 60 parts of gastrodia powder, 70 parts of yam powder, 80 parts of sea buckthorn fruit powder, and 7 parts of red yeast rice powder.

5. The product for lowering blood lipids as claimed in claim 1, wherein: The soaking time in step S1 is 12-16 hours.

6. The product for lowering blood lipids as claimed in claim 1, wherein: In step S2, the composite bacterial solution is inoculated at an inoculation rate of 2-5%.

7. The product for lowering blood lipids as claimed in claim 1, wherein: The steam sterilization in step S1 is steam sterilization in a high pressure steam sterilizer for 30 to 40 minutes.

8. The product for lowering blood lipids as claimed in claim 1, wherein: After draining in step S1, a nutrient supplement solution is added to the soybeans, the amount of the nutrient supplement solution added is 10-15% of the mass of the soybeans, and the nutrient supplement solution contains: 1g / L MgSO4·7H2O, 10g / L sucrose and 5g / L soy peptone.

9. A method for preparing a product according to any one of claims 1 to 8, characterized in that: The preparation method comprises: weighing various raw materials according to the formula, mixing, sterilizing and packaging.

10. Use of the product according to any one of claims 1 to 8 in the preparation of a product for lowering blood lipids.