Scalp brain signal acquisition method and system, medium and electronic equipment

Abstract

The invention provides a scalp brain signal acquisition method and system, a medium and electronic equipment, and relates to the technical field of brain-computer interfaces. The scalp brain signal acquisition method comprises the following steps: determining excitation signal parameters of FUS according to head acoustic parameters; the excitation signal parameters are used for enabling the irradiation focus of focused ultrasound FUS of the ultrasonic phase control transducer to be located on the scalp contour; in response to the ultrasonic stimulation instruction, controlling the ultrasonic phased transducer to generate an array element excitation signal based on the excitation signal parameter so as to perform ultrasonic irradiation on the irradiation focus; and in response to the electroencephalogram acquisition instruction, acquiring an electroencephalogram signal to obtain a focused ultrasound modulated scalp electroencephalogram signal. According to the method, the accuracy of the scalp electroencephalogram signals can be improved.

Description

Technical Field

[0001] The present application relates to the field of brain-computer interface technology, and in particular to a scalp brain signal acquisition method, system, medium and electronic equipment. Background Art

[0002] Electroencephalogram (EEG) is a technology that records brain electrical activity non-invasively. It has been applied to the study of brain sciences such as cognitive science, cognitive psychology, and neurolinguistics. Electrode caps are generally used in clinical testing and experiments to accurately and quickly determine the electrode placement and collect brain signals. Commercial electrode caps often use a 10-20 lead placement system, which is determined based on the 10-20 system developed by the International Electroencephalography Association in 1958. Each electrode records the discharge at a specific location on the scalp. Among them, the various waveform characteristics of EEG are important bases for judging the state of the brain and diagnosing brain diseases.

[0003] In order to break through the physical limits of high-density electrode arrays and improve the spatial resolution of scalp EEG from the source, researchers have combined focused ultrasound (FUS), which has the advantages of non-radiation, multiple focus targets and high spatial resolution, with EEG to develop ultrasound modulation of EEG signal technology. When FUS is used to modulate EEG signals, ultrasound will have problems such as defocusing and insufficient focal energy, and the accuracy of EEG signals is low. Therefore, there is an urgent need for a scalp brain signal acquisition method to improve the accuracy of scalp EEG signals. Summary of the invention

[0004] The embodiments of the present application provide a scalp brain signal acquisition method, system, medium and electronic device, which can improve the accuracy of scalp EEG signals.

[0005] In a first aspect, an embodiment of the present application provides a scalp brain signal acquisition method, which is applied to a scalp brain signal acquisition system, wherein the scalp brain signal acquisition system includes a focused ultrasound irradiation module and an electroencephalogram acquisition device; the electroencephalogram acquisition device includes electroencephalogram acquisition electrodes and an acquisition control module; the acquisition control module is used to control the electroencephalogram acquisition electrodes to acquire electroencephalogram signals; the focused ultrasound irradiation module includes an ultrasonic phased transducer; the method includes:

[0006] Determining the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer be located on the scalp contour;

[0007] In response to an ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus;

[0008] In response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal.

[0009] The scalp brain signal acquisition method provided in the embodiment of the present application can determine the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to ultrasonically irradiate the irradiation focus; in response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal, thereby setting the FUS focus on the scalp contour, avoiding the influence of the skull on the sound field, and ensuring the high-precision focusing of the FUS, effectively improving the accuracy of the focused ultrasound scalp focus, and improving the accuracy of the scalp EEG signal.

[0010] In a possible implementation, the scalp brain signal acquisition system further includes a simulation model building module and an ultrasound focusing simulation module;

[0011] The method further comprises:

[0012] Based on the head information of the subject and the irradiation structure parameters of the ultrasonic phased transducer, a biophysical simulation model is constructed in a preset coordinate system; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour;

[0013] The head acoustic parameter is determined according to the Hounsfield HU value included in the head information.

[0014] The scalp brain signal acquisition method provided in this embodiment constructs a biophysical simulation model in a preset coordinate system based on the head information of the subject and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour; the head acoustic parameters are determined according to the Henkel HU value included in the head information, thereby establishing a biophysical simulation model based on the subject's head information, effectively improving the accuracy of the focused ultrasound scalp focus, and improving the accuracy of the scalp EEG signal.

[0015] In a possible implementation, the biophysical simulation model is constructed in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer, including:

[0016] Based on the subject's head information, a head structure model is constructed;

[0017] Based on the head structure model and the irradiation structure parameters of the ultrasonic phased transducer, a biophysical simulation model is constructed in a preset coordinate system.

[0018] The scalp brain signal acquisition method provided in this embodiment constructs a head structure model based on the head information of the subject; and constructs a biophysical simulation model in a preset coordinate system based on the head structure model and the irradiation structure parameters of the ultrasonic phased transducer. This method can obtain a biophysical simulation model by combining the head structure model including the scalp contour, skull contour and brain tissue contour with the irradiation structure parameters of the ultrasonic phased transducer, and set the FUS focus on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures the high-precision focusing of the FUS, effectively improves the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp EEG signal.

[0019] In a possible implementation, the system further includes a data processing module; and the method further includes:

[0020] The focused ultrasound modulated scalp EEG signal is sent to a data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal.

[0021] In the method provided in this embodiment, the system further includes a data processing module; the method further includes: sending the focused ultrasound modulated scalp EEG signal to the data processing module so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal. The method sends the focused ultrasound modulated scalp EEG signal to the data processing module so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal, and provides a data post-processing interface, which can automatically perform post-processing on the focused ultrasound modulated scalp EEG signal, reduce the time spent on information processing of the focused ultrasound modulated scalp EEG signal, and improve the processing efficiency of the scalp EEG signal.

[0022] In a possible implementation, the system further includes a cell discharge calculation module; after determining the excitation signal parameters of the FUS according to the head acoustic parameters, and before responding to the ultrasound stimulation instruction and controlling the ultrasound phased transducer to generate an array element excitation signal based on the excitation signal parameters, the system further includes:

[0023] The irradiation amplitude is determined by the cell discharge calculation module; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0024] The method provided in this embodiment determines the irradiation amplitude through the cell discharge calculation module; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition represents that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold. This method determines the irradiation amplitude through the cell discharge calculation module, and can set the threshold condition that ultrasonic irradiation does not affect cell spontaneous discharge and can be collected with high signal-to-noise ratio, which provides a guarantee for the safety and effectiveness of focused ultrasound and further improves the accuracy of scalp EEG signals.

[0025] In a possible implementation, the system further includes a positioning module; and the method further includes:

[0026] The relative position of the ultrasonic phased transducer of the focused ultrasonic irradiation module and the irradiation focus is adjusted by the positioning module.

[0027] In the method provided in this embodiment, the system further includes a positioning module; the method further includes: adjusting the relative position of the ultrasonic phased-control transducer of the focused ultrasound irradiation module and the irradiation focus through the positioning module. The method, by adjusting the relative position of the ultrasonic phased-control transducer of the focused ultrasound irradiation module and the irradiation focus through the positioning module, can make the ultrasonic phased-control transducer of the focused ultrasound irradiation module be in a relative position corresponding to the irradiation focus, so that the FUS focus is located on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures the high-precision focusing of the FUS, effectively improves the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp electroencephalogram signal.

[0028] In a possible implementation, the system further includes a signal decoding module; and the method further includes:

[0029] In response to the source signal acquisition instruction, the signal decoding module performs high-frequency bandpass filtering on the focused ultrasound modulated scalp electroencephalogram signal when each irradiation focus is subjected to ultrasound irradiation to acquire an ultrasonic high-frequency signal;

[0030] Extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal;

[0031] Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal;

[0032] The ultrasonic decoded signal is raster scanned to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

[0033] The method provided in this embodiment, the system also includes a signal decoding module; the method also includes: in response to the source signal acquisition instruction, the signal decoding module performs high-frequency bandpass filtering on the focused ultrasound modulated scalp EEG signal when each irradiation focus is subjected to ultrasound irradiation to obtain an ultrasonic high-frequency signal; extracts the envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal; performs data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal; performs raster scanning on the ultrasonic decoding signal to obtain an EEG distribution map; the EEG distribution map includes decoding values ​​corresponding to each scanning grid point. The method provides a decoding mechanism for ultrasonic modulated scalp EEG signals, decodes the scalp EEG signal of the ultrasonic irradiation point by analyzing the typical characteristics of the ultrasonic modulated scalp EEG signal, accurately obtains the source signal of the ultrasonic irradiation target area, and improves the accuracy of the scalp EEG signal.

[0034] In a possible implementation, the head information includes head computerized tomography (CT) scan information, or magnetic resonance imaging (MRI) scan information.

[0035] In the method provided in this embodiment, the head information includes head electronic computer tomography (CT) scan information or magnetic resonance imaging (MRI) scan information. This method can build a biophysical simulation model based on the head electronic computer tomography (CT) scan information or magnetic resonance imaging (MRI) scan information, and can accurately model fine structures including scalp contours, skull contours, and brain tissue contours, thereby improving the accuracy of scalp EEG signals.

[0036] In a second aspect, an embodiment of the present application provides a scalp brain signal acquisition system, the system comprising:

[0037] A focused ultrasound irradiation module, used to determine the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, control the ultrasonic phased transducer to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus;

[0038] The EEG acquisition device is used to respond to the EEG acquisition instruction and acquire EEG signals to obtain focused ultrasound modulated scalp EEG signals; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals.

[0039] In a possible implementation, the system further includes:

[0040] A simulation model construction module, used to construct a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour;

[0041] The ultrasonic focusing simulation module is used to determine the head acoustic parameters according to the Hounsfield HU value included in the head information.

[0042] In a possible implementation, the simulation model construction module includes a head structure reconstruction submodule and a coupling structure creation submodule;

[0043] The head structure reconstruction submodule is used to construct a head structure model based on the subject's head information;

[0044] The coupling structure creation submodule is used to construct a biophysical simulation model in a preset coordinate system based on the head structure model and the irradiation structure parameters of the ultrasonic phased transducer.

[0045] In a possible implementation, the system further includes a data processing module;

[0046] The EEG acquisition device is also used to send the focused ultrasound modulated scalp EEG signal to the data processing module;

[0047] The data processing module is used to post-process the received focused ultrasound modulated scalp EEG signal.

[0048] In a possible implementation, the system further includes a cell discharge calculation module; the cell discharge calculation module is used to:

[0049] Determine the irradiation amplitude; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition represents that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0050] In a possible implementation, the system further includes a positioning module; the positioning module is used to adjust the relative position of the ultrasonic phased transducer of the focused ultrasonic irradiation module and the irradiation focus.

[0051] In a possible implementation, the system further includes a signal decoding module; the signal decoding module is used to:

[0052] In response to the source signal acquisition instruction, the focused ultrasound modulated scalp electroencephalogram signal is subjected to high-frequency bandpass filtering when each irradiation focus is subjected to ultrasound irradiation to acquire an ultrasonic high-frequency signal;

[0053] Extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal;

[0054] Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal;

[0055] The ultrasonic decoded signal is raster scanned to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

[0056] In a possible implementation, the head information includes head computerized tomography (CT) scan information, or magnetic resonance imaging (MRI) scan information.

[0057] In a third aspect, an embodiment of the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the method described in any one of the first aspects is implemented.

[0058] In a fourth aspect, an embodiment of the present application provides an electronic device, comprising a memory and a processor, wherein the memory stores a computer program executable on the processor, and when the computer program is executed by the processor, the method described in any one of the first aspects is implemented.

[0059] In a fifth aspect, an embodiment of the present application provides a computer program product, which includes computer instructions, and the computer instructions are stored in a computer-readable storage medium; when a processor of a computer device reads the computer instructions from the computer-readable storage medium, the processor executes the computer instructions, so that the computer device performs the steps of any one of the methods described in the first aspect.

[0060] The technical effects brought about by any implementation method of the second to fifth aspects can refer to the technical effects brought about by the implementation method of the first aspect, and will not be repeated here. BRIEF DESCRIPTION OF THE DRAWINGS

[0061] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative labor.

[0062] Figure 1 A schematic diagram of a scalp brain signal acquisition method provided in an embodiment of the present application;

[0063] Figure 2A schematic diagram of a flow chart of another scalp brain signal acquisition method provided in an embodiment of the present application;

[0064] Figure 3 A schematic diagram of a process for constructing a biophysical simulation model of a scalp brain signal acquisition method provided in an embodiment of the present application;

[0065] Figure 4 A schematic diagram of a signal decoding process of a scalp brain signal acquisition method provided in an embodiment of the present application;

[0066] Figure 5 One of the structural block diagrams of a scalp brain signal acquisition system provided in an embodiment of the present application;

[0067] Figure 6 The second structural block diagram of a scalp brain signal acquisition system provided in an embodiment of the present application;

[0068] Figure 7 A third structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0069] Figure 8 A fourth structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0070] Fig. 9 A fifth structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0071] Fig.10 A sixth structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0072] Fig.11 A seventh structural block diagram of another scalp brain signal acquisition system provided in an embodiment of the present application;

[0073] Fig.12 A structural block diagram of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0074] In order to make the purpose, technical solutions and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present application.

[0075] Electroencephalogram (EEG) is a technology that records brain electrical activity non-invasively. It has been applied to the study of brain sciences such as cognitive science, cognitive psychology, and neurolinguistics. Electrode caps are generally used in clinical testing and experiments to accurately and quickly determine the electrode placement and collect brain signals. Commercial electrode caps often use a 10-20 lead placement system, which is determined based on the 10-20 system developed by the International Electroencephalography Association in 1958. Each electrode records the discharge at a specific location on the scalp. Among them, the various waveform characteristics of EEG are important bases for judging the state of the brain and diagnosing brain diseases.

[0076] In order to break through the physical limits of high-density electrode arrays and improve the spatial resolution of scalp EEG from the source, researchers have combined focused ultrasound FUS, which has the advantages of non-radiation, multiple focus targets and high spatial resolution, with EEG to develop ultrasound modulation of EEG signal technology. When FUS is used to modulate EEG signals, ultrasound will have problems such as defocusing and insufficient focal energy, and the accuracy of EEG signals is low. Therefore, there is an urgent need for a scalp brain signal acquisition method to improve the accuracy of scalp EEG signals.

[0077] Based on this, the embodiments of the present application provide a scalp brain signal acquisition method, system, medium and electronic device. Among them, the scalp brain signal acquisition method is applied to the scalp brain signal acquisition system, which includes a focused ultrasound irradiation module and an electroencephalogram acquisition device; the electroencephalogram acquisition device includes electroencephalogram acquisition electrodes and an acquisition control module; the acquisition control module is used to control the electroencephalogram acquisition electrodes to acquire electroencephalogram signals; the focused ultrasound irradiation module includes an ultrasonic phased transducer; the method includes: determining the excitation signal parameters of the FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; responding to the ultrasonic stimulation instruction, based on the excitation signal parameters, controlling the ultrasonic phased transducer to generate an array element excitation signal to ultrasonically irradiate the irradiation focus; responding to the electroencephalogram acquisition instruction, acquiring electroencephalogram signals to obtain focused ultrasound modulated scalp electroencephalogram signals. This scalp brain signal acquisition method can set the FUS focus on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures the high-precision focusing of FUS, effectively improves the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of scalp EEG signals.

[0078] In order to make the invention purpose, technical scheme and advantages of the embodiments of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0079] The scalp brain signal acquisition method provided in the embodiment of the present application is further explained below. The scalp brain signal acquisition method provided in the present application is applied to a scalp brain signal acquisition system, which includes a focused ultrasound irradiation module and an electroencephalogram acquisition device; the electroencephalogram acquisition device includes electroencephalogram acquisition electrodes and an acquisition control module; the acquisition control module is used to control the electroencephalogram acquisition electrodes to acquire electroencephalogram signals; the focused ultrasound irradiation module includes an ultrasonic phased transducer; Figure 1 As shown, the following steps are included:

[0080] Step S101, determining the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer be located on the scalp contour.

[0081] In one embodiment of the present application, the propagation path and focal area of ​​ultrasound waves are calculated based on the Westervelt sound wave propagation equation and the Pennes biological heat conduction equation, and then the excitation parameters of the transducer are adjusted so that the ultrasound waves can be accurately and safely focused on the target area on the skull surface.

[0082] In some embodiments of the present application, the Westervelt sound wave propagation equation is specifically as follows:

[0083]

[0084] in, is the Laplace operator;

[0085] p is the sound pressure;

[0086] c is the speed of sound;

[0087] ρ is the material density;

[0088] t is the propagation time;

[0089] is the acoustic diffusion coefficient;

[0090] α is the absorption coefficient;

[0091] ω=2πf is the angular frequency;

[0092] f is the ultrasonic frequency;

[0093] β is the acoustic nonlinear coefficient.

[0094] In the above formula, the first and second terms represent the lossless propagation of linear waves, the third term represents the medium acoustic wave loss, and the fourth term represents the nonlinear propagation characteristics of the acoustic wave.

[0095] In some embodiments of the present application, the Pennes biological heat conduction equation is specifically as follows:

[0096]

[0097] in,

[0098] ρ is the medium density;

[0099] C r is the specific heat of the medium, and the medium refers to the medium in which ultrasound propagates;

[0100] T is the medium temperature;

[0101] t is the propagation time;

[0102] r ec is the thermal conductivity of the medium;

[0103] is the Laplace operator;

[0104] q is the heat generated per unit volume of the medium;

[0105] W B is the blood perfusion rate;

[0106] C B is the specific heat of blood flow.

[0107] In some embodiments of the present application, the head structure model and biophysical simulation model established above are used as simulation software, single / multi-focus targets are set, and the phase excitation signal of each array element is obtained based on the TM method (Traversal Modulation, TM traversal control method). The function an1(t) of exciting each array element of the ultrasonic phased transducer one by one is:

[0108] an1(t)=gp1(t)×sin(2πf0t),

[0109] in,

[0110] gp1(t) is a Gaussian pulse function;

[0111] f0 is the ultrasonic center frequency;

[0112] t is the propagation time.

[0113] The Gaussian pulse function is a type of function; for a certain ultrasonic phased transducer, the ultrasonic center frequency is an inherent property and its value is fixed.

[0114] A separate domain point probe is correspondingly set for each array element, and a domain point probe is also set at the preset focus, and the domain point probe is used to record the sound pressure signal.

[0115] When an1(t) excites each array element of the ultrasonic phased transducer one by one, a domain point probe is set at the preset target focus to record the sound pressure signal p emitted by each array element to the target focus in turn. i (t), p i (t) is fitted to generate a fitting signal, and the time t corresponding to the maximum sound pressure of the fitting signal is extracted i ; Calculate the t corresponding to each array element i The maximum value in is recorded as t0, and the array element corresponding to t0 is used as the reference array element. The delay phase between the remaining array elements and the reference array element is Δt i =t0-t i ; It can be obtained that the excitation signal of each array element after using the TM method is an TM_i (t):

[0116] an TM_i (t) = gp1(t-Δt i )×sin(2πf0(t-Δt i )).

[0117] In some embodiments of the present application, the excitation signal parameter of the FUS includes an excitation signal phase.

[0118] In some other embodiments of the present application, the excitation signal parameters of the FUS include an excitation signal amplitude and an excitation signal phase.

[0119] In some embodiments of the present application, the phase of the excitation signal is a preset fixed value.

[0120] Step S102 , in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus.

[0121] In specific implementation, after determining the excitation signal parameters of FUS, the user triggers an ultrasonic stimulation instruction. In response to the received ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus.

[0122] In an optional embodiment, the system further includes a positioning module; the method further includes:

[0123] The relative position of the ultrasonic phase-controlled transducer of the focused ultrasonic irradiation module and the irradiation focus is adjusted through the positioning module.

[0124] In some embodiments of the present application, the ultrasonic phased transducer includes a phase control unit, a power amplification unit, an electronic three-dimensional adjustment unit, a sound field scanning unit and a positioning unit; after the delay phase is calculated by the TM method, the delay signal of each array element including the delay phase is sent to the phase control unit through the serial port; the phase control unit triggers the array element excitation signal according to the delay sequence, and sends it to the power amplification unit in sequence; the power amplification unit generates an array element excitation signal of a set amplitude according to the stimulation sequence, and excites each array element to emit a sound wave.

[0125] The ultrasonic phased transducer is placed at the corresponding position in the simulation through the electronic three-dimensional adjustment unit, the sound field scanning unit and the positioning unit. Under the condition of ensuring the consistency of the sound field between the experiment and the simulation, the preset target point on the skull surface of the subject is further irradiated.

[0126] Step S103, responding to the EEG acquisition instruction, acquiring EEG signals to obtain focused ultrasound modulated scalp EEG signals.

[0127] The focused ultrasound modulated scalp EEG signal acquisition needs to be collected in an environment with good sound insulation, good air circulation, no strong light and no electromagnetic interference. Before the experiment begins, the subject adjusts the sitting posture to the best position on his own, and then the examiner puts on the electrode cap for the subject, and adjusts the impedance of all leads to be no greater than the preset impedance value, such as 5kΩ. In the embodiment of the present application, the EEG amplifier example uses the Neuroscan Curry9 system, selects appropriate reference electrodes and ground electrodes, sets the system sampling rate and power frequency trap, etc. After the EEG signal waveform of the subject is stable, collect a section of EEG signal before ultrasonic stimulation for reference; start the scalp brain signal acquisition system, perform ultrasonic irradiation according to the excitation signal parameters obtained by simulation, and collect a section of EEG signal during ultrasonic irradiation for information processing.

[0128] The scalp brain signal acquisition method provided in the above embodiment can determine the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus; in response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal, thereby setting the FUS focus on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures the high-precision focusing of the FUS, effectively improves the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp EEG signal.

[0129] In an optional embodiment, the scalp brain signal acquisition system further includes a simulation model building module and an ultrasound focusing simulation module; Figure 2 , the method further comprises the following steps:

[0130] Step S201 : constructing a biophysical simulation model in a preset coordinate system based on the head information of the subject and the irradiation structure parameters of the ultrasonic phased transducer.

[0131] The biophysical simulation model includes a head structure model and an irradiation structure contour of an ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour.

[0132] In an optional embodiment, the head information includes head computerized tomography (CT) scan information, or magnetic resonance imaging (MRI) scan information.

[0133] In an optional embodiment, based on the head information of the subject and the irradiation structure parameters of the ultrasonic phased transducer, a process of constructing a biophysical simulation model in a preset coordinate system is as follows: Figure 3 As shown, the following steps may be included:

[0134] Step S301, constructing a head structure model based on the subject's head information.

[0135] In specific implementation, the head information may be head CT scan information or head MRI scan information. In some embodiments of the present application, a head structure model is established based on the head computed tomography (CT) / magnetic resonance imaging (MRI) scan data of the subject.

[0136] In some embodiments of the present application, the skull comprises three layers of skull structures: outer cortical bone, middle cancellous bone, and inner cortical bone. The skull outline is the outline of the outer cortical bone.

[0137] In one embodiment of the present application, a head structure model is constructed based on the head information of the subject, which can be specifically based on the skull CT data of the subject to establish a three-dimensional skull discrete data map; further, based on the Hounsfield Unit (HU) value of the CT image, a three-layer skull structure of outer cortical bone, middle cancellous bone, inner cortical bone, and other fine structures such as scalp and brain tissue are divided to establish a head structure numerical simulation model.

[0138] Step S302: constructing a biophysical simulation model in a preset coordinate system based on the head structure model and the irradiation structure parameters of the ultrasonic phased transducer.

[0139] In specific implementation, the head structure model is constructed using the subject's head information, such as the HU value of CT data, and combined with the irradiation structure parameters of the ultrasonic phased transducer to establish a biophysical simulation model consistent with actual applications. The ultrasonic phased transducer structure parameters include but are not limited to the following information items: including the shape of the transducer, the number of array elements, the opening diameter, the array element diameter, the array element spacing, and the transducer geometric focal length.

[0140] Step S202: determining the head acoustic parameters according to the Hounsfield HU value included in the head information.

[0141] During specific implementation, the head acoustic parameters corresponding to the head structure model are determined according to the Henkel HU value included in the head information.

[0142] The scalp brain signal acquisition method provided in the above embodiment can construct a biophysical simulation model in a preset coordinate system based on the head information of the subject and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour; the head acoustic parameters are determined according to the Henkel HU value included in the head information; the excitation signal parameters of the FUS are determined according to the head acoustic parameters; the excitation signal parameters are used to make the focused ultrasonic FUS of the ultrasonic phased transducer The irradiation focus is located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to ultrasonically irradiate the irradiation focus; in response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal, thereby establishing a biophysical simulation model based on the subject's head information, and setting the FUS focus on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures the high-precision focusing of the FUS, effectively improves the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp EEG signal.

[0143] In the embodiments of the present application, the acoustic parameters include but are not limited to the following information items: medium porosity, material density, sound velocity, and absorption coefficient of the corresponding area.

[0144] In an optional embodiment, the calculation formula of the head acoustic parameters of each part of the head structure model is as follows:

[0145]

[0146] ρ=Φ×ρ water +(1-Φ)×ρ bone ,

[0147] c=c water +(1-Φ)×(c bone -c water ),

[0148] α=α water +Φ 0.5 ×(α bone -α water ),

[0149] Where Φ is the medium porosity of the corresponding area;

[0150] α bone 、c bone and ρ bone They represent the absorption coefficient, speed of sound, and density of the skull in turn;

[0151] α water 、c water and ρ water They represent the absorption coefficient, sound velocity, and density of water respectively;

[0152] H is the Heinz value;

[0153] ρ is the material density of the corresponding area;

[0154] c is the speed of sound in the corresponding area;

[0155] α is the absorption coefficient of the corresponding area.

[0156] In the embodiment of the present application, the corresponding area is the area of ​​the selected points in each part of the head structure model. In an optional embodiment, the system also includes a data processing module; after step S103, the scalp brain signal acquisition method also includes:

[0157] The focused ultrasound modulated scalp EEG signal is sent to a data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal.

[0158] In an optional embodiment, the system further includes a cell discharge calculation module; after determining the excitation signal parameters of the FUS according to the head acoustic parameters, before responding to the ultrasound stimulation instruction and controlling the ultrasound phased transducer to generate the array element excitation signal based on the excitation signal parameters, it also includes:

[0159] The irradiation amplitude is determined by the cell discharge calculation module; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0160] In an embodiment of the present application, the cell discharge calculation module may include an ultrasound modulated cell discharge sub-model; the ultrasound modulated cell discharge sub-model is obtained by combining a bilayer sonophore (BLS) model and a cell model based on Hodgkin-Huxley (HH).

[0161] In an embodiment of the present application, an ultrasound-modulated cell discharge submodel is used to determine a threshold range of ultrasound irradiation parameters.

[0162] When the cell bilayer membrane is irradiated by sinusoidal ultrasound, the maximum displacement Z of the lipid membrane relative to its static position satisfies the following RP equation (Rayleigh-Plesset equation):

[0163]

[0164] The radius of curvature of the cell bilayer leaflet is R(Z) = (r a 2 +Z 2 ) / (2Z);

[0165] r a is the diaphragm radius;

[0166] ρ1 is the density of cerebrospinal fluid (CSF);

[0167] ω=2πf is the angular frequency of the ultrasonic wave;

[0168] f is the center frequency;

[0169] t is the propagation time;

[0170] P in ,P M ,P ec ,P0,P A and P S (Z) are the pressures caused by internal gas pressure, molecular pressure, electrostatic pressure, static pressure, amplitude of applied ultrasound and leaflet tension;

[0171] δ0 is the thickness of the leaflet;

[0172] μ s is the dynamic viscosity of the leaflet;

[0173] μ1 is the dynamic viscosity of CSF.

[0174] Membrane capacitance C m and displacement Z i The related function is:

[0175]

[0176] in,

[0177] C m (Z i ) is the maximum displacement Z of the lipid membrane relative to its resting position i The membrane capacitance at

[0178] C m0 is the membrane capacitance of the bilipid membrane in the static state (P A =0Pa);

[0179] r a is the diaphragm radius;

[0180] Z i is the maximum displacement of the lipid membrane relative to its static position corresponding to each ultrasonic irradiation condition under different ultrasonic irradiation conditions, i represents the number of types of ultrasonic irradiation conditions;

[0181] Δ is the interval between leaflets.

[0182] The capacitive displacement current is:

[0183]

[0184] Where V is the membrane potential;

[0185] C m is the membrane capacitance;

[0186] t is the propagation time.

[0187] The interlobular distances of different cell types have certain values.

[0188] The HH equation for cell discharge under ultrasound irradiation is:

[0189]

[0190] in,

[0191] I Na ,I K ,I A ,I T ,I L ,I K-Ca and I l They are sodium current, delayed rectifier K + Current, A-type K + Current, low threshold Ca 2+ Current, high threshold Ca 2+ Current, Ca-dependent 2+ K + Current and leakage current;

[0192] I D is the capacitive displacement current;

[0193] C m is the membrane capacitance;

[0194] V is the membrane potential.

[0195] The calculation formula for each ion membrane current is:

[0196] I Na =g Na m 3 h(VV Na ),

[0197] I K =g K n 4 (VV K ),

[0198] I A =g A a 2 b(VV K ),

[0199] I T =g T p 2 q(VV Ca ),

[0200] I L =g L c 2 d1d2(VV Ca ),

[0201] I K-Ca =g K-Ca r 2 (VV K ),

[0202] I l =g l (VV l ),

[0203] Among them, a, b, c, d1, d2, h, m, n, p, q and r are activation or inactivation variables (under fixed conditions, activation or inactivation variables are fixed values);

[0204] V Na 、V K 、V Ca and V l are the reversal potentials of sodium, potassium, calcium, and leakage current, respectively;

[0205] g Na , g K , gA , g L , g T , g K-Ca and g l is the maximum conductance.

[0206] Ultrasonic spatial peak pulse average (SPPA) intensity I sppa The calculation formula is:

[0207]

[0208] Where c is the speed of sound;

[0209] P A Indicates the sound pressure amplitude;

[0210] ρ1 represents the density of the ultrasound propagation medium.

[0211] Cell firing rhythm si for:

[0212] f si =1 / Δt si ,

[0213] Among them, the time interval Δt between two consecutive discharge spikes si for:

[0214] Δt si =t i+1 -t i ,

[0215] t i is the time instant of the ith spike discharged by the cell.

[0216] In some embodiments of the present application, sppa =0W / m 2 The rhythm curve of spontaneous cell discharge during ultrasound stimulation was used as a benchmark, and the discharge rhythm curve after ultrasound stimulation was correlated with it by Pearson, the frequency difference between the two was calculated, and the Pearson correlation coefficient before and after stimulation was set to be greater than or equal to 0.9, indicating that the effect of ultrasound stimulation on cell discharge was negligible, which was a safe and effective ultrasound threshold condition.

[0217] In some embodiments of the present application, the purpose of using ultrasound is spatial positioning, so that the impact of ultrasound on scalp cells is as small as possible. Therefore, in some embodiments of the present application, an ultrasound threshold condition is set to ensure that the irradiation energy of ultrasound on the scalp does not exceed the impact threshold of the ultrasound threshold condition.

[0218] In some embodiments of the present application, signal decoding may also be performed on the focused ultrasound modulated scalp EEG signal.

[0219] In an optional embodiment, the system further comprises a signal decoding module; the method, such as Figure 4 As shown, the following steps are also included:

[0220] Step S401, in response to a source signal acquisition instruction, a signal decoding module performs high-frequency bandpass filtering on a focused ultrasound modulated scalp electroencephalogram signal when ultrasound irradiation is performed on each irradiation focus to acquire an ultrasound high-frequency signal.

[0221] Step S402: extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal.

[0222] Step S403, performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal.

[0223] Step S404, raster scanning is performed on the ultrasonic decoded signal to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

[0224] In some embodiments of the present application, the voltage signal collected by Curry9 when each target point is irradiated with ultrasound is used as the original data, and the original data is preprocessed by removing 50Hz power frequency interference and downsampling to 4kHz; the preprocessed data is band-pass filtered at the ultrasound pulse repetition frequency (Pulse Repetition Frequencies, PRF) ±50Hz to retain the high-frequency signal at the PRF; the envelope signal of the high-frequency signal that passes the band-pass filter is extracted using Hilbert transform; 20s of envelope signal data are selected and divided into 20 segments of data with an interval of 1s, the data are peak aligned, and superimposed and averaged to obtain a 1s envelope signal, which is a decoded signal of the ultrasound irradiation point; the decoded signal of each point during ultrasound raster scanning can be used to obtain a high spatial resolution EEG distribution map of the region of interest (ROI) on the scalp surface.

[0225] In some embodiments of the present application, the decoded signal of each point during ultrasonic grid scanning is used, specifically, ultrasonic grid scanning is used, and the data collected at each scanning point is passed through a data processing module to obtain a decoded value corresponding to each scanning grid point.

[0226] In some embodiments of the present application, the decoded value corresponding to each scanning grid point includes the amplitude of the decoded signal.

[0227] In some embodiments of the present application, the area scanned by ultrasound is the area of ​​interest. By scanning each point by ultrasound, the amplitude of the decoded signal of each point is decoded, and these values ​​are plotted into a distribution diagram to obtain a high spatial resolution EEG distribution diagram.

[0228] The scalp brain signal acquisition method provided in the above embodiment can determine the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus; in response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal, thereby setting the FUS focus on the scalp contour, which not only avoids the influence of the skull on the sound field, but also ensures the high-precision focusing of the FUS, effectively improves the accuracy of the focused ultrasound scalp focus, and can improve the accuracy of the scalp EEG signal.

[0229] Based on the same inventive concept, a scalp brain signal acquisition system is also provided in the embodiment of the present application. Since the system is the system corresponding to the scalp brain signal acquisition method in the embodiment of the present application, and the principle of solving the problem by the system is similar to that of the method, the implementation of the system can refer to the implementation of the above method, and the repeated parts will not be repeated.

[0230] Figure 5 FIG. 1 shows a schematic diagram of the structure of a scalp brain signal acquisition system provided in an embodiment of the present application. The scalp brain signal acquisition system is as follows: Figure 5 As shown, it includes: a focused ultrasound irradiation module 501 and an EEG acquisition device 502.

[0231] Among them, the focused ultrasound irradiation module 501 is used to determine the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus;

[0232] The EEG acquisition device 502 is used to respond to the EEG acquisition instruction and acquire EEG signals to obtain focused ultrasound modulated scalp EEG signals; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals.

[0233] In the embodiments of the present application, the EEG acquisition device may also be referred to as an EEG acquisition device module.

[0234] In one possible implementation, Figure 6 As shown, the system also includes:

[0235] The simulation model construction module 601 is used to construct a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour;

[0236] The ultrasound focusing simulation module 602 is used to determine the head acoustic parameters according to the Hounsfield HU value included in the head information.

[0237] In one possible implementation, Figure 7 As shown, the simulation model construction module 601 includes a head structure reconstruction submodule 701 and a coupling structure creation submodule 702;

[0238] The head structure reconstruction submodule 701 is used to construct a head structure model based on the subject's head information;

[0239] The coupling structure creation submodule 702 is used to construct a biophysical simulation model in a preset coordinate system based on the head structure model and the irradiation structure parameters of the ultrasonic phased transducer.

[0240] In one possible implementation, Figure 8 As shown, the system further includes a data processing module 801;

[0241] The EEG acquisition device 502 is also used to send the focused ultrasound modulated scalp EEG signal to the data processing module 801;

[0242] The data processing module 801 is used to post-process the received focused ultrasound modulated scalp EEG signal.

[0243] In one possible implementation, Fig. 9 As shown, the system further includes a cell discharge calculation module 901; the cell discharge calculation module 901 is used to:

[0244] Determine the irradiation amplitude; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition represents that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

[0245] In some embodiments of the present application, the irradiation amplitude determined by the cell discharge calculation module 901 can be used to adjust the excitation signal amplitude included in the excitation signal parameters based on the irradiation amplitude to obtain the adjusted excitation signal parameters; the adjusted excitation signal parameters are used for the focused ultrasound irradiation module 501 to respond to the ultrasound stimulation instruction and control the ultrasound phased transducer to generate the array element excitation signal to perform ultrasound irradiation on the irradiation focus. That is, when receiving the ultrasound stimulation instruction, the focused ultrasound irradiation module 501 responds to the received ultrasound stimulation instruction and controls the ultrasound phased transducer to generate the array element excitation signal based on the adjusted excitation signal parameters to perform ultrasound irradiation on the irradiation focus.

[0246] In some embodiments of the present application, adjusting the excitation signal amplitude included in the excitation signal parameters based on the irradiation amplitude includes: if the excitation signal amplitude included in the excitation signal parameters is smaller than the irradiation amplitude, keeping the excitation signal amplitude included in the excitation signal parameters unchanged; if the excitation signal amplitude included in the excitation signal parameters is larger than the irradiation amplitude, reducing the excitation signal amplitude included in the excitation signal parameters to the irradiation amplitude.

[0247] In some embodiments of the present application, the excitation signal amplitude included in the excitation signal parameters is adjusted based on the irradiation amplitude, including: if the excitation signal amplitude included in the excitation signal parameters is less than the irradiation amplitude, the excitation signal amplitude included in the excitation signal parameters remains unchanged; if the excitation signal amplitude included in the excitation signal parameters is greater than the irradiation amplitude, the excitation signal amplitude included in the excitation signal parameters is reduced to a target irradiation amplitude; wherein the target irradiation amplitude is the product of the irradiation amplitude and a preset safety factor; and the value range of the preset safety factor is (0,1).

[0248] In one possible implementation, Fig.10 As shown, the system further includes a positioning module 1001; the positioning module 1001 is used to adjust the relative position of the ultrasonic phased transducer of the focused ultrasonic irradiation module and the irradiation focus.

[0249] In one possible implementation, Fig.11 As shown, the system further includes a signal decoding module 1101; the signal decoding module 1101 is used to:

[0250] In response to the source signal acquisition instruction, high-frequency bandpass filtering is performed on the focused ultrasound modulated scalp electroencephalogram signal when each irradiation focus is subjected to ultrasound irradiation to acquire an ultrasound high-frequency signal;

[0251] Extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal;

[0252] Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal;

[0253] The ultrasonic decoded signal is raster scanned to obtain an EEG distribution map; the EEG distribution map includes a decoded value corresponding to each scanned grid point.

[0254] In a possible implementation, the head information includes head computerized tomography (CT) scan information, or magnetic resonance imaging (MRI) scan information.

[0255] Based on the same inventive concept as the above method embodiment, an electronic device is also provided in the embodiment of the present application. The electronic device can be used for brain signal acquisition. In one embodiment, the electronic device can be a server or other electronic device. In this embodiment, the structure of the electronic device can be as follows: Fig.12 As shown, it includes a memory 1201 , a communication module 1203 and one or more processors 1202 .

[0256] The memory 1201 is used to store computer programs executed by the processor 1202. The memory 1201 may mainly include a program storage area and a data storage area, wherein the program storage area may store an operating system and programs required for running the instant messaging function, etc.; the data storage area may store various instant messaging information and operation instruction sets, etc.

[0257] The memory 1201 may be a volatile memory, such as a random-access memory (RAM); the memory 1201 may also be a non-volatile memory, such as a read-only memory, a flash memory, a hard disk drive (HDD) or a solid-state drive (SSD), or the memory 1201 is any other medium that can be used to carry or store the desired program code in the form of instructions or data structures and can be accessed by a computer, but is not limited thereto. The memory 1201 may be a combination of the above memories.

[0258] The processor 1202 may include one or more central processing units (CPU) or a digital processing unit, etc. The processor 1202 is used to implement the above scalp brain signal acquisition method when calling the computer program stored in the memory 1201 .

[0259] The communication module 1203 is used to communicate with terminal devices or other servers.

[0260] The specific connection medium between the memory 1201, the communication module 1203 and the processor 1202 is not limited in the embodiment of the present application. Fig.12In the embodiment, the memory 1201 and the processor 1202 are connected via a bus 1204. The bus 1204 is connected to the processor 1202 via a bus 1204. Fig.12 The connections between other components are shown in bold lines, and are not intended to be limiting. Bus 1204 can be divided into address bus, data bus, control bus, etc. For ease of representation, Fig.12 Only one thick line is used in the diagram, but this does not mean that there is only one bus or only one type of bus.

[0261] An embodiment of the present application further provides a computer-readable storage medium, in which computer-executable instructions are stored. The computer-executable instructions are used to implement the scalp brain signal acquisition method of any embodiment of the present application.

[0262] According to one aspect of the present application, a computer program product or computer program is provided, which includes computer instructions stored in a computer-readable storage medium. The processor of the computer device reads the computer instructions from the computer-readable storage medium, and the processor executes the computer instructions, so that the computer device performs the scalp brain signal acquisition method in the above embodiment. The program product can use any combination of one or more readable media. The readable medium can be a readable signal medium or a readable storage medium. The readable storage medium can be, for example, - but not limited to - an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device or device, or any combination of the above. More specific examples of readable storage media (non-exhaustive list) include: an electrical connection with one or more wires, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the above.

[0263] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be covered by the protection scope of the present application.

Claims

1. A scalp brain signal acquisition method, applied to a scalp brain signal acquisition system, characterized in that: The scalp brain signal acquisition system includes a focused ultrasound irradiation module and an EEG acquisition device; the EEG acquisition device includes an EEG acquisition electrode and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrode to acquire EEG signals; The focused ultrasound irradiation module includes an ultrasonic phased transducer; the method includes: determining an excitation signal parameter of FUS according to head acoustic parameters; the excitation signal parameter is used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer be located on the scalp contour; In response to an ultrasonic stimulation instruction, based on the excitation signal parameters, the ultrasonic phased transducer is controlled to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus; In response to the EEG acquisition instruction, the EEG signal is acquired to obtain a focused ultrasound modulated scalp EEG signal.

2. The method according to claim 1, characterized in that The scalp brain signal acquisition system also includes a simulation model construction module and an ultrasound focusing simulation module; The method further comprises: Based on the head information of the subject and the irradiation structure parameters of the ultrasonic phased transducer, a biophysical simulation model is constructed in a preset coordinate system; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour; The head acoustic parameter is determined according to the Hounsfield HU value included in the head information.

3. The method according to claim 2, characterized in that The method of constructing a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer includes: Based on the subject's head information, a head structure model is constructed; Based on the head structure model and the irradiation structure parameters of the ultrasonic phased transducer, a biophysical simulation model is constructed in a preset coordinate system.

4. The method according to claim 1, characterized in that: The system further includes a data processing module; the method further includes: The focused ultrasound modulated scalp EEG signal is sent to a data processing module, so that the data processing module performs post-processing on the focused ultrasound modulated scalp EEG signal.

5. The method according to claim 1, characterized in that The system further includes a cell discharge calculation module; after determining the excitation signal parameters of the FUS according to the head acoustic parameters, and before responding to the ultrasound stimulation instruction and controlling the ultrasound phased transducer to generate an array element excitation signal based on the excitation signal parameters, the system further includes: The irradiation amplitude is determined by the cell discharge calculation module; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition indicates that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

6. The method according to claim 1, characterized in that The system further includes a positioning module; and the method further includes: The relative position of the ultrasonic phased transducer of the focused ultrasonic irradiation module and the irradiation focus is adjusted by the positioning module.

7. The method according to claim 1, characterized in that The system further includes a signal decoding module; the method further includes: In response to the source signal acquisition instruction, the signal decoding module performs high-frequency bandpass filtering on the focused ultrasound modulated scalp electroencephalogram signal when each irradiation focus is subjected to ultrasound irradiation to acquire an ultrasonic high-frequency signal; Extracting an envelope signal from the acquired ultrasonic high-frequency signal to obtain an ultrasonic envelope signal; Performing data segmentation and superposition averaging on the obtained ultrasonic envelope signal to obtain an ultrasonic decoding signal; The ultrasonic decoded signal is raster scanned to obtain an EEG distribution map; the EEG distribution map includes a decoding value corresponding to each scanning grid point.

8. The method according to claim 1, characterized in that The head information includes head computer tomography (CT) scanning information or magnetic resonance imaging (MRI) scanning information.

9. A scalp brain signal acquisition system, characterized in that: The system comprises: A focused ultrasound irradiation module, used to determine the excitation signal parameters of FUS according to the acoustic parameters of the head; the excitation signal parameters are used to make the irradiation focus of the focused ultrasound FUS of the ultrasonic phased transducer located on the scalp contour; in response to the ultrasonic stimulation instruction, based on the excitation signal parameters, control the ultrasonic phased transducer to generate an array element excitation signal to perform ultrasonic irradiation on the irradiation focus; The EEG acquisition device is used to respond to the EEG acquisition instruction and acquire EEG signals to obtain focused ultrasound modulated scalp EEG signals; the EEG acquisition device includes EEG acquisition electrodes and an acquisition control module; the acquisition control module is used to control the EEG acquisition electrodes to acquire EEG signals.

10. The system according to claim 9, characterized in that The system further comprises: A simulation model construction module, used to construct a biophysical simulation model in a preset coordinate system based on the subject's head information and the irradiation structure parameters of the ultrasonic phased transducer; the biophysical simulation model includes a head structure model and an irradiation structure contour of the ultrasonic phased transducer; the head structure model includes a scalp contour, a skull contour and a brain tissue contour; The ultrasonic focusing simulation module is used to determine the head acoustic parameters according to the Hounsfield HU value included in the head information.

11. The system according to claim 9, characterized in that The system also includes a data processing module; The EEG acquisition device is also used to send the focused ultrasound modulated scalp EEG signal to the data processing module; The data processing module is used to post-process the received focused ultrasound modulated scalp EEG signal.

12. The system according to claim 9, characterized in that The system further comprises a cell discharge calculation module; the cell discharge calculation module is used to: Determine the irradiation amplitude; the irradiation amplitude is the maximum amplitude that makes the cell spontaneous discharge rhythm curve before and after ultrasonic stimulation meet the preset ultrasonic threshold condition; the ultrasonic threshold condition represents that the influence of ultrasonic stimulation on cell discharge is less than the preset influence threshold.

13. The system according to claim 9, characterized in that The system further comprises a positioning module, wherein the positioning module is used to adjust the relative position of the ultrasonic phased-control transducer of the focused ultrasonic irradiation module and the irradiation focus.

14. An electronic device, characterized in that: The method comprises a memory and a processor, wherein the memory stores a computer program that can be run on the processor, and when the computer program is executed by the processor, the method described in any one of claims 1 to 8 is implemented.

15. A computer-readable storage medium, wherein a computer program is stored in the computer-readable storage medium, characterized in that: When the computer program is executed by a processor, the method according to any one of claims 1 to 8 is implemented.

16. A computer program product, characterized in that It includes computer instructions, which are stored in a computer-readable storage medium; when a processor of a computer device reads the computer instructions from the computer-readable storage medium, the processor executes the computer instructions, so that the computer device executes the steps of the method described in any one of claims 1 to 8.

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