Traditional Chinese medicine composition and traditional Chinese medicine preparation for clearing heat from throat and preparation method and application of traditional Chinese medicine composition and traditional Chinese medicine preparation

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and mainly relates to a traditional Chinese medicine composition for clearing heat from throat, a traditional Chinese medicine preparation and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 0.9 to 1.5 parts by weight of radix scrophulariae, 1.2 to 5.0 parts by weight of radix polygonati officinalis, 1.0 to 3.0 parts by weight of radix glehniae, 1.0 to 1.5 parts by weight of radix rehmanniae, 1.0 to 3.0 parts by weight of radix ophiopogonis, 1.5 to 6.0 parts by weight of gypsum and 0.5 to 3.0 parts by weight of liquorice root. The preparation method of the traditional Chinese medicine preparation comprises the working procedures of processing, burdening, extracting, concentrating, preparing a soft material, granulating, drying and finishing granules. The traditional Chinese medicine composition or the traditional Chinese medicine preparation for clearing heat from throat can relieve symptoms such as red and swollen pharynx, dry mouth and dry throat, pharyngalgia, pharynx itching, scorching fever, less phlegm and foreign body sensation of pharynx caused by heat evil, and has a remarkable curative effect on chronic pharyngitis. Through a unified preparation method, the accuracy of the quality and dosage of the used medicinal materials and the stability of the treatment effect are ensured.

Description

Technical Field

[0001] The invention belongs to the technical field of Chinese medicine preparations, and mainly relates to a Chinese medicine composition for clearing the throat, a Chinese medicine preparation, and a preparation method and application thereof. Background Art

[0002] Chronic pharyngitis is a common pharyngeal disease, and its incidence is more significant in cities with severe air pollution and widespread transportation. Patients usually experience pharyngeal discomfort in the early stages, such as tension in the throat and a foreign body sensation, but as the disease progresses, the symptoms will recur without clear signs. At present, modern medicine has not yet found an ideal and efficient drug to cure chronic pharyngitis. Common treatments include oral lozenges, sprays, etc. Although these treatments can temporarily relieve symptoms, once stimulated by external factors, the disease is prone to relapse and cannot fundamentally solve the problem. In addition, traditional Western medicine treatments often use non-steroidal anti-inflammatory drugs combined with antibacterial drugs, but long treatment cycles may cause gastrointestinal reactions, liver and kidney damage, dizziness, rashes and other side effects, and the treatment effect is not lasting. In traditional Chinese medicine, Chinese medicine has a good effect on chronic pharyngitis caused by heat evil, especially when symptoms such as redness and swelling of the throat, dry mouth and throat, sore throat, itchy throat, burning sensation, and less sputum occur. However, Chinese herbal decoctions have certain difficulties in quality control, and measurement errors are prone to occur during the preparation process. In addition, the decoctions are difficult to store and easily deteriorate, which also causes certain inconveniences for patients when using them. In the present invention, strict management regulations are imposed on the origin, quality, storage and transportation of the original medicinal materials, and then a unified production process, quality standard and detection method are formulated for each medicinal material according to the properties of its effective ingredients, and a dosage conversion relationship between granules and original drugs is scientifically formulated, thereby ensuring the quality and dosage of the medicinal materials and thus ensuring the efficacy. Summary of the invention

[0003] The purpose of the present invention is to provide a Chinese medicine composition for clearing the throat, a Chinese medicine preparation and a preparation method and application thereof, aiming to solve the problems raised in the above background technology.

[0004] The purpose of the present invention is achieved through the following technical solutions: A throat-clearing and relieving pharyngeal Chinese medicine composition is composed of the following Chinese medicines in parts by weight: 0.9-1.5 parts by weight of Scrophularia ningpoensis, 1.2-5.0 parts by weight of Polygonatum odoratum, 1.0-3.0 parts by weight of Glehnia littoralis, 1.0-1.5 parts by weight of Rehmannia glutinosa, 1.0-3.0 parts by weight of Ophiopogon japonicus, 1.5-6.0 parts by weight of Gypsum and 0.5-3.0 parts by weight of Licorice.

[0005] Further, the Chinese medicine composition is composed of the following Chinese medicines in parts by weight: 1.5 parts by weight of Scrophularia, 2.0 parts by weight of Polygonatum, 2.0 parts by weight of Adenophora, 1.5 parts by weight of Rehmannia, 1.5 parts by weight of Ophiopogon, 1.5 parts by weight of Gypsum and 1.0 parts by weight of Licorice. The weight ratio of Scrophularia, Rehmannia, Ophiopogon and Gypsum is 1:1:1:1; the weight ratio of Polygonatum and Adenophora is 1:1; the weight ratio of Polygonatum and Glycyrrhiza is 2:1; the weight ratio of Scrophularia and Glycyrrhiza is 1.5:1.

[0006] A throat-clearing and throat-removing Chinese medicinal preparation is composed of the above-mentioned Chinese medicinal composition and pharmaceutical excipients.

[0007] A method for preparing the above-mentioned throat-clearing and throat-relief Chinese medicine preparation comprises the following steps: (1) Processing step: processing the Chinese medicine in the Chinese medicine composition to obtain Chinese medicine pieces; (2) batching process: weighing the Chinese herbal medicine pieces according to the amount of the Chinese herbal medicine composition; (3) Extraction process: putting the weighed Chinese herbal medicine pieces into an extraction tank, soaking, extracting, filtering to obtain an extract, and pumping the extract into a storage tank; in the extraction process, extracting twice in total, adding 6 times the amount of water to the extraction tank for the first time, and adding 4 times the amount of water for the second time, and decocting for 1 hour each time; soaking for 40 minutes before the first decoction; filtering with a 100-mesh sieve into the storage tank; (4) Concentration process: The extract in the storage tank is pumped into the concentration equipment for reduced pressure concentration (vacuum degree is -0.06 to -0.08 MPa, concentration pressure is ≤0.2 MPa) to obtain an extract with a relative density of 1.25 to 1.30 at 60°C; (5) Soft material preparation process: the auxiliary material, the extract and the wetting agent are uniformly mixed to obtain the soft material; wherein the ratio of the extract to the auxiliary material is 1:2.5, the auxiliary material is dextrin and sucrose, the particle size of the sucrose is 100 mesh, and the ratio of dextrin to sucrose is 1:0.4; the wetting agent is 75% ethanol, and the amount of 75% ethanol is 15-20% of the total raw material amount; (6) Granulation process: granulate the soft material and sieve it to obtain particles of uniform size; (7) Drying process: Dry the particles at a temperature of 60 to 80° C. for 30 to 50 minutes; preferably, the drying temperature is 60° C. and the drying time is 30 minutes.

[0008] (8) Granulation process: The dry granules are granulated. The top screen of the oscillating sieve is a 10-mesh screen and the bottom screen is an 80-mesh screen. The granules after granulation are placed in a clean stainless steel turnover barrel, sealed, weighed, and labeled.

[0009] An application of the above-mentioned Chinese medicine composition in the preparation of a drug for treating chronic pharyngitis, wherein chronic pharyngitis is caused by pathogenic heat and is characterized by redness and swelling of the pharynx, dry mouth and pharynx, pharyngeal pain, itchy pharynx, burning sensation, little sputum, and a foreign body sensation.

[0010] An application of the above-mentioned traditional Chinese medicine preparation in preparing a medicine for treating chronic pharyngitis, wherein chronic pharyngitis is caused by pathogenic heat and is characterized by redness and swelling of the pharynx, dry mouth and pharynx, pharyngeal pain, itchy pharynx, burning sensation, little sputum, and a foreign body sensation.

[0011] Furthermore, the dosage form of the drug is granules, capsules, tablets, pills or powders.

[0012] The present invention has the following beneficial effects: The throat-clearing and throat-relief Chinese medicine composition or Chinese medicine preparation provided by the present invention can effectively relieve symptoms such as throat redness and swelling, dry mouth and throat, throat pain, throat itching, burning, less sputum, and foreign body sensation in the throat caused by pathogenic heat, and shows significant therapeutic effect on the treatment of chronic pharyngitis, effectively relieving the pain of patients. At the same time, by unifying the preparation method of the throat-clearing and throat-relief Chinese medicine preparation, the quality of the medicinal materials used and the accuracy of the dosage are ensured, thereby further ensuring the stability and reliability of its therapeutic effect.

[0013] When filtering the extract, a 100-mesh screen is used, and the filtering speed is moderate. The obtained extract has good clarity, which avoids the problem that when the screen aperture is large, the filtering speed is fast, but the interception effect of insoluble components is poor, which affects the clarity of the solution, and when the screen aperture is small, although the interception effect is good, it will lead to too slow filtering speed, thereby affecting work efficiency. The extract is concentrated to an extract with a relative density of 1.25-1.30 at 60°C. Not only can the concentrate be poured out, but it also lays a good foundation for the next drying process, avoiding the problem that the relative density of the extract is too small, affecting the normal operation of the next process and extending the production cycle, and the relative density is too large, which is not conducive to pouring out and transferring, thereby affecting work efficiency. The present invention adopts a wet granulation process, so that the particles have the advantages of smooth and beautiful appearance, uniform size, uniform color, good fluidity, strong wear resistance and good compression forming, and also has the advantages of simple equipment, easy operation, low investment, low energy consumption and high production efficiency; The present invention develops it into granules, which have the advantages of accurate measurement, rapid dissolution, convenient carrying and stable properties. Moreover, this dosage form of granules is consistent with the rapid action characteristics of the original preparation decoction to the greatest extent, and overcomes the disadvantage of the inconvenience of decocting the decoction before use. In addition, the granules are delicious, small in size, convenient to take, store and transport, and have the characteristics of rapid absorption, rapid effect, convenience, stability and good taste. DETAILED DESCRIPTION

[0014] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of protection of the present invention. In addition, it should be understood that after reading the contents disclosed in the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalent forms also fall within the scope of protection defined by the present invention.

[0015] Example 1

[0016] This embodiment provides a Chinese medicine composition for clearing the throat and relieving pharynx, and the Chinese medicine composition is composed of the following Chinese medicines: Scrophularia 166.7g, Polygonatum odoratum 222.2g, Adenophora australis 222.2g, Rehmannia glutinosa 166.7g, Ophiopogon japonicus 166.7g, Gypsum 166.7g, Licorice root 111.1g.

[0017] The effects of each Chinese medicine in this embodiment are as follows: (1) Scrophularia: Its chemical components include alkaloids, sugars, sterols, amino acids, fatty acids, trace volatile oils, carotene, etc., among which the main chemical components are cycloterpenoid compounds. In addition, Scrophularia contains phenylpropanoid glycosides angoroside C and trace volatile oils, phytosterols, oleic acid, stearic acid, glucose, asparagine and alkaloids. It has the functions of nourishing yin and reducing fire, relieving restlessness and detoxifying. It can treat yin damage caused by febrile diseases, red tongue, thirst, rashes, bone steaming and fatigue fever, restless sleep, spontaneous sweating, constipation caused by body fluid damage, vomiting blood and epistaxis, sore throat, carbuncle, scrofula, rashes caused by warm toxins, red eyes, diphtheria, etc.

[0018] (2) Polygonatum odoratum: contains a variety of compounds such as flavonoids, polysaccharides, saponins, and volatile oils. Most of the flavonoids in Polygonatum odoratum are high isoflavones; the polysaccharides are mainly neutral polysaccharides, mainly composed of glucose and mannose, and also contain a small amount of galactose; the steroidal saponins in Polygonatum odoratum saponins are the main active ingredients, namely spirostanol steroidal saponins and furostanol steroidal saponins. It has the effects of nourishing yin and moistening dryness, promoting body fluid and quenching thirst. It is mainly used to treat dry cough, cough due to fatigue, dry throat and thirst due to loss of yin fluid due to fever, internal heat and thirst, yin deficiency and external infection, dizziness, and muscle and vein spasm.

[0019] (3) Adenophora adenophora: Contains zanthoxylum toxin, alloimperatorin, scopoletin, quinceanine, bergamot lactone, secoisoarsinol, caffeic acid, syringin, coumarin compounds and other ingredients. It has the effects of nourishing yin and clearing the lungs, benefiting the stomach and promoting fluid, resolving phlegm and invigorating qi. It is used for dry cough due to lung heat, cough due to yin deficiency, dry cough with sticky phlegm, insufficient stomach yin, loss of appetite and vomiting, insufficient qi and yin, irritability, heat and dry mouth.

[0020] (4) Rehmannia root: contains amino acid components, trace elements, glycosides, cyclopentanes and other chemical substances. Cyclopentane glycosides are the characteristic components of Rehmannia root. The chemical structure of cyclopentane has the characteristics of hemiacetal and cyclopentane. Now, 8 kinds of sugars have been separated and identified from Rehmannia root, including stachyose, raffinose, glucose, sucrose, fructose, mannotriose, verbascose and galactose, among which stachyose accounts for the highest proportion. It has the effects of anti-inflammatory and antipyretic, anti-aging, clearing heat and cooling blood, nourishing yin and promoting body fluid. It can be used for fever, rashes, hematemesis, nosebleeds caused by heat entering the blood, thirst, constipation, sore throat, etc. caused by heat damage to yin and body fluid.

[0021] (5) Ophiopogon japonicus: It contains a variety of amino acids and sugar components, which can increase the secretion of water and lubricating fluid in the body, thereby playing a role in nourishing yin and moistening dryness; the polysaccharides and flavonoids contained in it have a strong effect of clearing heat and detoxifying, and can be used to treat symptoms such as fever and oral ulcers; the polysaccharides and flavonoids in Ophiopogon japonicus have a certain antioxidant effect, which can remove free radicals in the body and prevent oxidative damage; the polysaccharides and flavonoids in Ophiopogon japonicus have a certain anti-inflammatory and analgesic effect.

[0022] (6) Gypsum: The main chemical component is calcium sulfate (CaSO 4 ) is a monoclinic mineral. It has the effects of clearing away heat and purging fire, relieving restlessness and quenching thirst; the calcium it contains has an inhibitory effect on nerves and muscles, and is more suitable for patients with restlessness. And as an auxiliary therapeutic drug, it also has a certain antispasmodic effect on convulsions caused by high fever, and can be used to quench thirst and stomach heat thirst; it can also inhibit the body temperature regulation center, reduce the excitability of skeletal muscles, and reduce vascular permeability. Therefore, it has an anti-inflammatory effect.

[0023] (7) Licorice: It contains a variety of active ingredients, including triterpenoid saponins (such as glycyrrhizic acid and glycyrrhetinic acid), flavonoids (such as liquiritin and isoliquiritigenin), polysaccharides, amino acids and trace elements. Among them, glycyrrhizic acid and liquiritin are its main active ingredients and have significant pharmacological effects. Licorice has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain and harmonizing various medicines, and is widely used in clinical Chinese medicine.

[0024] The sources of legal standards for various Chinese medicines are as follows: (1) Scrophularia: This product is the dried root of Scrophularia ningpoensis Hemsl. of the Scrophulariaceae family. Remove the remaining rhizomes and impurities, wash, soak thoroughly, and cut into thin slices. Origin: Hubei.

[0025] This product should comply with the relevant provisions under Scrophularia on page 121 of Volume 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0026] (2) Polygonatum odoratum: This product is the dried rhizome of Polygonatum odoratum (Mill.) Druce, a plant of the Liliaceae family. Remove impurities, wash, soak thoroughly, cut into thick slices, and dry. Origin: Hunan.

[0027] This product should comply with the relevant provisions under Polygonatum odoratum on page 86 of Volume 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0028] (3) Glehnia littoralis: This product is the dried root of Glehnia littoralis Fr. Schmidt exMiq. of the Umbelliferae family. Remove the remaining stems and impurities, moisten slightly, cut into sections, and dry. Origin: Hebei.

[0029] This product should comply with the relevant provisions under Northern Adenophora on page 103 of Volume 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0030] (4) Rehmannia: This product is the dried root of Rehmannia glutinosa Libosch., a plant of the Scrophulariaceae family. Rehmannia is slowly baked until it is about 80% dry and is commonly known as "raw Rehmannia". Origin: Henan.

[0031] This product should comply with the relevant provisions under Rehmannia glutinosa on page 129 of the 2020 edition of the Chinese Pharmacopoeia.

[0032] (5) Ophiopogon japonicus This product is the dried root of Ophiopogon japonicus (L. f.) Ker-Gawl. of the Liliaceae family. Remove impurities, wash, soak, flatten, and dry. Origin: Sichuan.

[0033] This product should comply with the relevant provisions under Ophiopogon japonicus on page 162 of Volume 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0034] (6) Gypsum: This product is a sulfate mineral gypsum family gypsum, mainly containing hydrated calcium sulfate (CaSO4·2H2O). After mining, the rocks and sand are removed, and the gypsum is crushed and ground into coarse powder. Origin: Shandong.

[0035] This product should comply with the relevant provisions under Gypsum on page 98 of Volume 1 of the 2020 edition of the Chinese Pharmacopoeia.

[0036] (7) Licorice: This product is the dried root and rhizome of Glycyrrhiza uralensis Fisch. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the Leguminosae family. After digging, remove impurities, wash, soak, cut into thick slices, and dry. Origin: Mainly produced in Inner Mongolia, Gansu, Xinjiang and other places.

[0037] This product complies with the relevant provisions under licorice on page 88 of the 2020 edition of the Chinese Pharmacopoeia.

[0038] Scrophulariae is sweet and cold, nourishes yin, and is bitter and cold, clears heat. It has the functions of nourishing yin and clearing heat, detoxifying and dispersing knots, and clearing the throat. It is aimed at the main pathogenesis of heat-excessive damage to body fluid, internal heat-toxicity, and throat discomfort, so it is the main medicine; Polygonatum, Ophiopogon japonicus, and Rehmannia glutinosa are sweet and juicy, nourishing yin and clearing heat, and promoting body fluid and moistening the throat. Adenophora scabra is sweet and slightly bitter, and is good at nourishing yin and moistening the lungs, and can clear and relieve lung heat. The above four flavors are used together to enhance the main medicine's function of nourishing yin and promoting body fluid, and clearing the throat, and are the minister medicine; the foot yangming stomach passes through the throat, and gypsum belongs to the lung and stomach meridian, which is good at clearing the heat of the lungs and stomach, detoxifying and reducing swelling, and is an adjuvant. Licorice has the functions of nourishing the spleen and replenishing qi, clearing heat and detoxifying, removing phlegm and relieving cough, relieving urgency and relieving pain, and harmonizing various medicines, and is the guiding medicine. The combination of various medicines can play the effects of clearing the throat and moistening the throat, nourishing yin and promoting body fluid, and reducing swelling and relieving pain.

[0039] All Chinese medicines were purchased from Anhui Yuankang Chinese Medicine Pieces Co., Ltd. and Hebei Hu's Yubo Pharmaceutical Co., Ltd. The companies have complete certificates and licenses, the quality of the Chinese medicines they operate is stable, and their quality standards comply with the requirements of the "Chinese Pharmacopoeia" and meet the basic requirements for supplier audits.

[0040] Example 2

[0041] This embodiment provides a method for preparing a throat-clearing and throat-relief Chinese medicine preparation, comprising the following steps: (1) Processing step: processing the Chinese medicine in the Chinese medicine composition to obtain Chinese medicine pieces; (2) Batching process: The operator shall verify the name and quantity of the Chinese herbal medicine pieces to be fed according to the production instructions and weigh them for use.

[0042] (3) Extraction process: Put the correctly prepared and weighed raw materials into the extraction tank, soak for 40 minutes before extraction, extract twice, add 6 times and 4 times the amount of water respectively, boil for 1 hour each time, combine the decoctions; filter through a 100-mesh sieve and put into a storage tank.

[0043] (4) Concentration process: The extract in the storage tank is pumped into the concentration equipment for reduced pressure concentration. The vacuum degree is controlled at -0.06 to -0.08 MPa, the concentration pressure is ≤0.2 MPa, and the concentration temperature is 60°C. The liquid medicine is concentrated to a relative density of 1.25 to 1.30 to form an extract. The extract is placed in a clean stainless steel turnover barrel, weighed, labeled, and transferred to the next process.

[0044] (5) Soft material preparation process: dextrin and sucrose are selected as auxiliary materials. According to the operating procedures, after the dextrin and sucrose are collected and the weight is verified to be correct, they are put into a wet granulation mixer and stirred for 15 minutes to mix them evenly. Then, the extract required for granulation is added, and an appropriate amount of 75% ethanol is added and stirred to make a soft material that "can be held in a ball and falls apart when touched".

[0045] (6) Granulation process: Place the prepared soft material into a swing-type granulator for granulation; use a 14-mesh nylon screen to make uniform-sized granules according to the operating procedures and connect them to the material tray. During granulation, check the shape of the granules at any time and tighten the screen in time. If large pieces of soft material fall off, stop the machine immediately and replace the screen.

[0046] (7) Drying process: Place the wet granules on a drying tray and dry them in a drying oven at 60°C for 30 minutes.

[0047] (8) Granulation process: According to the granulation operation procedures, the dry granules are granulated and passed through an oscillating sieve with a top mesh of 10 and a bottom mesh of 80. The granules after granulation are placed in a clean turnover barrel, sealed, weighed, and labeled.

[0048] In one embodiment of the present invention, various Chinese medicinal pieces are weighed in proportion, and each portion is soaked in water 6 times the weight of the Chinese medicinal piece. The water absorption of the medicinal material increases over time, and after soaking for 40 minutes, the water absorption reaches saturation.

[0049] In one embodiment of the present invention, the soaking time of the medicinal material is 40 minutes, and the water absorption rate is 176%.

[0050] In one embodiment of the present invention, the average extract rate of three batches of verification tests was 31.33%, which was almost consistent with the orthogonal test result (in the orthogonal test, the process of extracting twice, adding 6 times the amount of water for the first time, adding 4 times the amount of water for the second time, and boiling for 1 hour each time, the extract rate was 31.30%), indicating that the process is stable and feasible.

[0051] In one embodiment of the present invention, the Chinese herbal medicine pieces are extracted twice, 6 times the amount of water is added for the first time, and 4 times the amount of water is added for the second time. The pieces need to be soaked for 40 minutes before the first decoction, and each decoction takes 1 hour.

[0052] In one embodiment of the present invention, when filtering the extract, a 100-mesh screen is used, and the filtering speed is moderate, and the obtained extract has good clarity.

[0053] In one embodiment of the present invention, the relative density of the decoction concentrate is too large, and it is difficult to completely pour out due to poor fluidity, resulting in waste, while the relative density is too small, which is not conducive to drying. The extract is concentrated to a relative density of 1.25-1.30 (60°C), so that the concentrate can not only be poured out, but also lay a good foundation for the next drying process.

[0054] In one embodiment of the present invention, when the concentration temperature is 60°C, the liquid medicine has good fluidity and is easy to pour out. When the concentration temperature is 70°C, the liquid medicine has good fluidity and is easy to pour out. Considering the production efficiency and production cost, the concentration temperature is selected to be 60°C.

[0055] In one embodiment of the present invention, dextrin and sucrose are selected as auxiliary materials, and the ratio of extract to auxiliary materials is 1:2.5. The particles have good formability and are easy to granulate.

[0056] In one embodiment of the present invention, when the ratio of extract to auxiliary material is fixed at 1:2.5 and the ratio of dextrin to sucrose in the auxiliary material is 1:0.4, the particle forming rate is high, and the granulation effect is better when the soft material is mixed for 15 minutes at this ratio, so the mixing time of the extract and the auxiliary material is determined to be 15 minutes.

[0057] In one embodiment of the present invention, 75% ethanol is selected as the wetting agent, which has good wettability and dispersibility, and the soft material has moderate viscosity, and the particles are easy to form and loose.

[0058] In one embodiment of the present invention, the granules made by the 14-mesh screen are selected, the granule packing amount is stable, the granule size is uniform, and the forming is good.

[0059] In one embodiment of the present invention, the particles are dried at 60° C. for 30 minutes, and the particles are in good condition, easy to be granulated, and have low moisture content.

[0060] Clinical cases: The cases of 100 patients were randomly selected from the China-Japan Friendship Hospital of Jilin University during 2020-2024.

[0061] Target group: It is used for redness and swelling of the throat, dry mouth and throat, sore throat, itchy throat, burning sensation, little sputum, and foreign body sensation caused by heat evil; patients with chronic pharyngitis with the above symptoms.

[0062] The distribution of patients is as follows: Patient gender / age distribution Number of outpatient medical records of patients aged 20-30 Number of outpatient medical records of patients aged 31-40 Number of outpatient medical records of patients aged 41-50 Number of outpatient medical records of patients aged 51-60 Number of outpatient medical records of patients aged 61-70 Is it a special population? Number of outpatient medical records of female patients 9 10 11 8 9 no Number of outpatient medical records of male patients 11 11 11 12 8 no A retrospective analysis of clinical cases shows that the throat-clearing and throat-relief Chinese medicine preparation provided by the present invention effectively alleviates the symptoms of throat redness and swelling, dry mouth and throat, throat pain, throat itching, burning sensation, less sputum, and foreign body sensation in the throat caused by pathogenic heat, shows significant therapeutic effect on the treatment of chronic pharyngitis, and effectively relieves the pain of patients.

[0063] Typical cases are listed below: Typical case 1: Name: Han Chief complaint: recurrent sore throat and hoarseness; Physical examination: red tongue, yellow fur, slippery and rapid pulse, normal body temperature; Auxiliary examination: Oropharyngeal examination was performed, and the pharynx was slightly edematous; Diagnosis: Laryngeal paralysis caused by pathogenic heat (chronic pharyngitis); Follow-up visit: symptoms of hoarseness, sore throat, dry mouth and throat have improved.

[0064] Typical case 2: Name: Yang; Chief complaint: intermittent foreign body sensation in the throat, occasionally with a little sputum; Physical examination: red tongue, yellow fur, slippery and rapid pulse, hyperplasia of follicles on the posterior pharyngeal wall, normal body temperature; Auxiliary examination: oropharyngeal examination, pharyngeal redness and swelling; Diagnosis: Laryngeal paralysis caused by pathogenic heat (chronic pharyngitis); Follow-up visit: The foreign body sensation in the throat improved after repeated throat clearing, and the amount of sputum decreased.

[0065] Typical case 3: Name: Gong Moumou; Chief complaint: intermittent hoarseness and sore throat; Physical examination: red tongue, yellow fur, slippery and rapid pulse, hyperplasia of follicles on the posterior pharyngeal wall, normal body temperature; Auxiliary examination: oropharyngeal examination, pharyngeal blood vessels dilation; Diagnosis: Laryngeal paralysis caused by pathogenic heat (chronic pharyngitis); Follow-up visit: symptoms of hoarseness, sore throat, dry mouth and throat have improved.

[0066] Typical case 4: Name: Jiang XX; Chief complaint: persistent foreign body sensation in the throat, with occasional small amount of sputum; Physical examination: red tongue, yellow fur, slippery and rapid pulse, hyperplasia of follicles on the posterior pharyngeal wall, normal body temperature; Auxiliary examination: Oropharyngeal examination was performed, and a small amount of secretions were produced; Diagnosis: Laryngeal paralysis caused by pathogenic heat (chronic pharyngitis); Follow-up visit: The foreign body sensation in the throat has improved and the amount of sputum has decreased.

[0067] Typical case 5: Name: He XX; Chief complaint: recurrent hoarseness and sometimes cough; Physical examination: red tongue, yellow fur, slippery and rapid pulse, normal body temperature; Auxiliary examination: Oropharyngeal examination was performed, and a small amount of secretions were produced; Diagnosis: Laryngeal paralysis caused by pathogenic heat (chronic pharyngitis); Follow-up visit: hoarseness, occasional cough, sore throat and itchy throat have improved.

[0068] The above are only preferred embodiments of the present invention. It should be pointed out that, for those skilled in the art, several modifications and improvements can be made without departing from the concept of the present invention. These should also be regarded as the protection scope of the present invention. These will not affect the effect of the implementation of the present invention and the practicality of the patent.

Claims

1. A Chinese medicine composition for clearing the throat, characterized in that: The Chinese medicine composition is composed of the following Chinese medicines in parts by weight: 0.9-1.5 parts by weight of Scrophularia ningpoensis, 1.2-5.0 parts by weight of Polygonatum odoratum, 1.0-3.0 parts by weight of Glehnia littoralis, 1.0-1.5 parts by weight of Rehmannia glutinosa, 1.0-3.0 parts by weight of Ophiopogon japonicus, 1.5-6.0 parts by weight of Gypsum Fibrosum and 0.5-3.0 parts by weight of Licorice.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition consists of the following Chinese medicines in parts by weight: 1.5 parts by weight of Scrophularia ningpoensis, 2.0 parts by weight of Polygonatum odoratum, 2.0 parts by weight of Glehnia littoralis, 1.5 parts by weight of Rehmannia glutinosa, 1.5 parts by weight of Ophiopogon japonicus, 1.5 parts by weight of Gypsum Fibrosum and 1.0 parts by weight of Licorice.

3. A Chinese medicine preparation for clearing the throat, characterized in that: The invention is composed of the Chinese medicine composition according to claim 1 or 2 and pharmaceutical excipients.

4. A method for preparing the throat-clearing and throat-relief Chinese medicine preparation according to claim 3, characterized in that: The following steps are involved: (1) Processing step: processing the Chinese medicine in the Chinese medicine composition to obtain Chinese medicine pieces; (2) batching process: weighing the Chinese herbal medicine pieces according to the amount of the Chinese herbal medicine composition; (3) Extraction process: putting the weighed Chinese herbal medicine pieces into an extraction tank, soaking, extracting, filtering to obtain an extract, and pumping the extract into a storage tank; in the extraction process, extracting twice in total, adding 6 times the amount of water to the extraction tank for the first time, and adding 4 times the amount of water for the second time, and decocting for 1 hour each time; soaking for 40 minutes before the first decoction; filtering with a 100-mesh sieve into the storage tank; (4) Concentration step: The extract in the storage tank is pumped into the concentration equipment for concentration to obtain an extract having a relative density of 1.25 to 1.30 at 60°C; (5) Soft material preparation process: the auxiliary material, the extract and the wetting agent are uniformly mixed to obtain the soft material; wherein the ratio of the extract to the auxiliary material is 1:2.5, the auxiliary material is dextrin and sucrose, the particle size of the sucrose is 100 mesh, the ratio of dextrin to sucrose is 1:0.4; the wetting agent is 75% ethanol; (6) Granulation process: granulating the soft material and sieving to obtain particles of uniform size; (7) Drying process; (8) Granulation process.

5. Use of the Chinese medicine composition according to claim 1 or 2 in preparing a drug for treating chronic pharyngitis, characterized in that: Chronic pharyngitis is a chronic pharyngitis caused by heat evil, which is characterized by redness and swelling of the throat, dry mouth and throat, sore throat, itchy throat, burning sensation, little sputum, and a foreign body sensation.

6. Use of the Chinese medicine preparation according to claim 3 in preparing a drug for treating chronic pharyngitis, characterized in that: Chronic pharyngitis is a chronic pharyngitis caused by heat evil, which is characterized by redness and swelling of the throat, dry mouth and throat, sore throat, itchy throat, burning sensation, little sputum, and a foreign body sensation.

7. The use according to claim 5 or 6, characterized in that: The dosage form of the medicine is granules, capsules, tablets, pills or powders.