Traditional Chinese medicine composition for treating allergic rhinitis as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis, which is prepared from the following raw materials in parts by weight: 6 to 30 parts of folium mori, 6 to 30 parts of flos chrysanthemi, 1 to 9 parts of radix ginseng, 10 to 30 parts of fructus ziziphi jujubae, 3 to 10 parts of rhizoma zingiberis recens, 3 to 10 parts of liquorice root, 10 to 30 parts of radix astragali seu hedysari, 3 to 12 parts of radix angelicae sinensis, 6 to 15 parts of radix ophiopogonis, 1 to 6 parts of radix puerariae, 3 to 12 parts of radix angelicae dahuricae, 3 to 9 parts of herba menthae and 3 to 10 parts of radix platycodonis. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) respectively taking the raw materials in parts by weight, and adding water to soak for 1 hour; step 2) adding water and decocting twice, adding 400-900 parts by volume of water each time, boiling and decocting with strong fire for the first time, adding water and boiling with slow fire for the second time, and combining decoctions; and (3) adding pharmaceutically acceptable medicinal auxiliary agents according to a conventional process to prepare clinically acceptable granules, pills, tablets, powder or capsules. The traditional Chinese medicine composition has the effects of resisting allergy, inflammation and bacteria and the like, and can relieve the symptoms of nasal obstruction, running nose, sneezing and the like of allergic rhinitis patients.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine composition for treating allergic rhinitis, and a preparation method and application thereof. Background Art

[0002] Allergic rhinitis, also known as allergic rhinitis, is a chronic nasal disease that is prevalent worldwide. Its pathogenesis involves complex interactions between immune responses and environmental factors. Patients usually experience typical symptoms such as nasal congestion, runny nose, continuous sneezing, nasal itching, itchy eyes, and tearing after contact with specific allergens, such as pollen, dust mites, and animal dander. These symptoms not only affect the daily quality of life of patients, but may also trigger a series of chain reactions such as sleep disorders, reduced work efficiency, and psychological distress.

[0003] Currently, the treatment strategies for allergic rhinitis are mainly divided into three categories: drug therapy, immunotherapy, and lifestyle adjustment. Although drug therapy can quickly relieve symptoms, long-term use may lead to side effects such as drug tolerance, nasal dryness, and decreased sense of smell; although immunotherapy may achieve long-term disease control, its treatment cycle is long, the cost is high, and it is not effective for all patients; lifestyle adjustments, such as avoiding contact with allergens and keeping the room clean, can help reduce the onset of symptoms, but it is difficult to cure the disease fundamentally.

[0004] In view of the limitations of Western medical treatment and the growing demand of patients for natural therapies, traditional Chinese medicine has shown unique advantages in the treatment of allergic rhinitis due to its unique theoretical system, rich clinical experience and low side effects. According to Chinese medicine theory, allergic rhinitis is often related to the dysfunction of the lungs, spleen and kidneys. Treatment should focus on harmonizing the internal organs, dispersing wind and cold, replenishing qi and strengthening the exterior, and clearing the orifices and stopping nosebleeds. Therefore, the development of a Chinese medicine composition based on Chinese medicine theory, using natural Chinese herbal medicines as raw materials and with definite efficacy is of great significance to meet the treatment needs of patients with allergic rhinitis and improve their quality of life. Summary of the invention

[0005] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a Chinese medicine composition for treating allergic rhinitis and a preparation method and application thereof.

[0006] To solve the above technical problems, the technical solution provided by the present invention is a traditional Chinese medicine composition for treating allergic rhinitis, which is composed of the following drug components: mulberry leaves, chrysanthemums, ginseng, jujubes, ginger, licorice, astragalus, angelica, ophiopogon, kudzu root, angelica dahurica, mint, and platycodon.

[0007] Furthermore, the ginseng is replaced by codonopsis pilosula.

[0008] Furthermore, the Chinese medicine composition includes the following raw materials in parts by weight: 6-30 parts of mulberry leaves, 6-30 parts of chrysanthemums, 1-9 parts of ginseng, 10-30 parts of jujubes, 3-10 parts of ginger, 3-10 parts of licorice, 10-30 parts of astragalus, 3-12 parts of angelica, 6-15 parts of ophiopogon, 1-6 parts of kudzu root, 3-12 parts of angelica, 3-9 parts of mint, and 3-10 parts of platycodon.

[0009] Furthermore, the Chinese medicine composition includes the following raw materials in parts by weight: 18 parts of mulberry leaves, 18 parts of chrysanthemums, 5 parts of ginseng, 20 parts of jujubes, 7 parts of ginger, 7 parts of licorice, 20 parts of astragalus, 7 parts of angelica, 11 parts of ophiopogon, 4 parts of kudzu root, 7 parts of angelica, 6 parts of mint, and 7 parts of platycodon.

[0010] Furthermore, the Chinese medicine composition includes the following raw materials in parts by weight: 6-30 parts of mulberry leaves, 6-30 parts of chrysanthemums, 3-12 parts of codonopsis pilosula, 10-30 parts of jujubes, 3-10 parts of ginger, 3-10 parts of licorice, 10-30 parts of astragalus, 3-12 parts of angelica, 6-15 parts of ophiopogon, 1-6 parts of kudzu root, 3-12 parts of angelica, 3-9 parts of mint, and 3-10 parts of platycodon.

[0011] Furthermore, the Chinese medicine composition includes the following raw materials in parts by weight: 16 parts of mulberry leaves, 19 parts of chrysanthemums, 8 parts of codonopsis pilosula, 19 parts of jujubes, 7 parts of ginger, 6 parts of licorice, 20 parts of astragalus, 6 parts of angelica, 10 parts of ophiopogon, 4 parts of kudzu root, 7 parts of angelica dahurica, 6 parts of mint, and 6 parts of platycodon.

[0012] Furthermore, the preparation method of the Chinese medicine composition comprises the following steps:

[0013] Step 1) taking raw materials by weight respectively, and soaking them in water for 1 hour;

[0014] Step 2) boiling the mixture twice, adding 400-900 parts by volume of water each time, boiling the mixture over high heat for 45-55 minutes for the first time, and boiling the mixture over low heat for 35-45 minutes for the second time, and combining the decoctions obtained from the two times;

[0015] Step 3) adding pharmaceutically acceptable adjuvants according to conventional processes to prepare clinically acceptable granules, pills, tablets, powders or capsules.

[0016] The second object of the present invention is to provide the use of the above-mentioned Chinese medicine composition in the preparation of medicine for treating allergic rhinitis.

[0017] The sources of raw materials used in the present invention are as follows:

[0018] Mulberry leaves: contain flavonoids, which have anti-inflammatory and anti-allergic effects.

[0019] Chrysanthemum: Contains volatile oils and flavonoids, which have anti-inflammatory and anti-allergic effects.

[0020] Ginseng / Codonopsis: Contains ginsenosides, which have the effects of enhancing immunity and resisting fatigue.

[0021] Astragalus: Contains astragalus polysaccharides, which have the effects of enhancing immunity and anti-inflammatory.

[0022] Jujube: Contains cyclic adenosine monophosphate, which has the effects of enhancing immunity and anti-allergic.

[0023] Ginger: Contains curcumin, which has antibacterial and anti-inflammatory properties.

[0024] Licorice: Contains glycyrrhizic acid, which has anti-inflammatory and anti-allergic effects.

[0025] Angelica: Contains volatile oils and polysaccharides, which have the effects of nourishing blood, activating blood circulation and anti-inflammatory.

[0026] Ophiopogon japonicus: Contains steroidal saponins, which have the effects of nourishing yin and moistening the lungs and anti-inflammatory.

[0027] Pueraria root: Contains puerarin, which has antipyretic and anti-inflammatory effects.

[0028] Angelica dahurica: Contains volatile oil, which has the effects of dispelling wind and cold and anti-inflammatory.

[0029] Mint: Contains menthol, which has anti-inflammatory and anti-allergic effects.

[0030] Platycodon grandiflorum: Contains saponins, which have expectorant and anti-inflammatory effects.

[0031] The Chinese medicine composition of the present invention is based on the principle of monarch, minister, assistant and envoy compatibility, wherein:

[0032] Sovereign drugs: mulberry leaves and chrysanthemum. Mulberry leaves have the effects of dispersing wind-heat, clearing the lungs and moistening dryness; chrysanthemum has the effects of dispersing wind-heat, clearing the liver and improving eyesight. The two drugs are used together as sovereign drugs, which play the role of dispersing wind-heat, clearing the lungs and opening the orifices, and treat the main cause of allergic rhinitis - wind-heat invasion.

[0033] Minister drugs: Astragalus, Angelica, Ophiopogon, Pueraria. Astragalus has the effects of replenishing qi and strengthening the exterior, promoting diuresis and reducing swelling; Angelica has the effects of replenishing blood and activating blood circulation, regulating menstruation and relieving pain; Ophiopogon has the effects of nourishing yin and promoting body fluid, moistening the lungs and clearing the heart; Pueraria has the effects of relieving muscles and reducing fever, promoting body fluid and quenching thirst. The four drugs are used together as minister drugs, which play the role of replenishing qi and nourishing blood, promoting body fluid and moistening dryness, enhancing the efficacy of the monarch drug, and regulating the patient's constitution at the same time.

[0034] Auxiliary drugs: Angelica dahurica, mint, platycodon grandiflorum, jujube, licorice, ginger. Angelica dahurica has the effects of dispelling wind and relieving pain, and clearing the nasal passages; mint has the effects of evacuating wind and heat, clearing the head; platycodon grandiflorum has the effects of clearing the lungs and removing phlegm, relieving throat and draining pus; jujube has the effects of tonifying the middle and replenishing qi, nourishing blood and calming the mind; licorice has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying; ginger has the effects of warming the middle and relieving pain, killing bacteria and detoxifying. The six drugs are used together as adjuvants, which play the role of dispelling wind and relieving pain, clearing the lungs and removing phlegm, and harmonizing various drugs, and assist the monarch and minister drugs in the treatment of allergic rhinitis.

[0035] Assistant drug: Ginseng (or Codonopsis). Ginseng has the effect of greatly replenishing vital energy, tonifying the spleen and benefiting the lungs; Codonopsis has the effect of replenishing the middle and replenishing qi, strengthening the spleen and benefiting the lungs. As an assistant drug, ginseng (or Codonopsis) can enhance the overall efficacy of the combination and guide the drugs directly to the diseased area.

[0036] The advantages of the present invention compared with the prior art are:

[0037] The Chinese medicine composition of the present invention adopts the principle of compatibility of monarch, minister, assistant and envoy, and all the medicines are used together to play the effects of dispersing wind-heat, promoting lung function and opening the orifices, invigorating qi and nourishing blood, promoting body fluid and moistening dryness, dispelling wind and relieving pain, and promoting lung function and removing phlegm. Among them, mulberry leaf and chrysanthemum are monarch medicines, which treat the main causes of allergic rhinitis; astragalus, angelica, ophiopogon and kudzu root are assistant medicines, which enhance the efficacy of the monarch medicine and regulate the patient's physique at the same time; angelica, mint, platycodon, jujube, licorice and ginger are assistant medicines, which assist the monarch and minister medicines in jointly treating allergic rhinitis; ginseng (or codonopsis) is an assistant medicine, which enhances the overall therapeutic effect of the composition.

[0038] The Chinese medicine composition of the present invention has significant anti-allergic, anti-inflammatory, antibacterial and other effects, can effectively relieve symptoms such as nasal congestion, runny nose, sneezing and the like in patients with allergic rhinitis, and has little side effects. DETAILED DESCRIPTION

[0039] The following is a further detailed description of a Chinese medicine composition for treating allergic rhinitis, a preparation method and an application of the present invention in conjunction with embodiments.

[0040] Example 1

[0041] A Chinese medicine composition for treating allergic rhinitis, comprising the following raw materials in parts by weight: 18 parts of mulberry leaves, 18 parts of chrysanthemums, 5 parts of ginseng, 20 parts of jujubes, 7 parts of ginger, 7 parts of liquorice, 20 parts of astragalus, 7 parts of angelica, 11 parts of ophiopogon, 4 parts of kudzu root, 7 parts of angelica, 6 parts of mint, and 7 parts of platycodon;

[0042] The preparation method of the Chinese medicine composition comprises the following steps:

[0043] Step 1) taking raw materials by weight respectively, and soaking them in water for 1 hour;

[0044] Step 2) boiling the mixture with water twice, adding 500 parts by volume of water each time, boiling the mixture with high heat for 50 minutes for the first time, and boiling the mixture with low heat for 40 minutes for the second time, and combining the decoctions obtained from the two times;

[0045] Step 3) Concentrating the extract under reduced pressure to 0.25 times of the original volume to obtain a concentrated solution;

[0046] Step 4) vacuum drying the concentrated liquid, controlling the pressure to 4 kPa, the drying temperature to 35° C., and vacuum drying for 10 minutes to obtain a Chinese medicine concentrate.

[0047] Take dextrin according to 4% of the weight of the prepared traditional Chinese medicine concentrate and add it to the traditional Chinese medicine composition. After mixing, use a tablet press to compress the tablets to obtain tablet medicines.

[0048] Example 2

[0049] A Chinese medicine composition for treating allergic rhinitis, comprising the following raw materials in parts by weight: 16 parts of mulberry leaves, 19 parts of chrysanthemums, 8 parts of codonopsis pilosula, 19 parts of jujubes, 7 parts of ginger, 6 parts of liquorice, 20 parts of astragalus, 6 parts of angelica, 10 parts of ophiopogon, 4 parts of kudzu root, 7 parts of angelica dahurica, 6 parts of mint, and 6 parts of platycodon;

[0050] The preparation method of the Chinese medicine composition comprises the following steps:

[0051] Step 1) taking raw materials by weight respectively, and soaking them in water for 1 hour;

[0052] Step 2) boiling the mixture twice, adding 600 parts by volume of water each time, boiling the mixture over high heat for 49 minutes for the first time, and boiling the mixture over low heat for 41 minutes for the second time, and combining the decoctions obtained from the two times;

[0053] Step 3) Concentrating the extract under reduced pressure to 0.2 times of the original volume to obtain a concentrated solution;

[0054] Step 4) vacuum drying the concentrated solution, controlling the pressure to 3 kPa, the drying temperature to 32° C., and vacuum drying for 35 minutes to obtain a Chinese medicine concentrate;

[0055] Starch and lactose are taken according to 4.5% of the weight of the prepared traditional Chinese medicine concentrate, wherein the ratio of starch to lactose is 1:1, and added into the traditional Chinese medicine composition, and granules are prepared after mixing, so as to obtain the granular medicine.

[0056] The present invention and its implementation methods are described above, and such description is not restrictive. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design structures and embodiments similar to the technical solution without creativity, which should all fall within the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating allergic rhinitis, characterized in that: The traditional Chinese medicine composition consists of the following medicinal components: mulberry leaves, chrysanthemum, ginseng, jujube, ginger, liquorice, astragalus, angelica, ophiopogon, kudzu root, angelica dahurica, mint and platycodon.

2. The Chinese medicine composition according to claim 1, characterized in that: The ginseng is replaced by codonopsis pilosula.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition comprises the following raw materials in parts by weight: 6-30 parts of mulberry leaves, 6-30 parts of chrysanthemums, 1-9 parts of ginsengs, 10-30 parts of jujubes, 3-10 parts of ginger, 3-10 parts of liquorice, 10-30 parts of astragalus, 3-12 parts of angelica, 6-15 parts of ophiopogon, 1-6 parts of kudzu root, 3-12 parts of angelica, 3-9 parts of mints, and 3-10 parts of platycodon.

4. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 18 parts of mulberry leaves, 18 parts of chrysanthemums, 5 parts of ginsengs, 20 parts of jujubes, 7 parts of ginger, 7 parts of liquorice, 20 parts of astragalus, 7 parts of angelica, 11 parts of ophiopogon, 4 parts of kudzu roots, 7 parts of angelica dahurica, 6 parts of mints, and 7 parts of platycodon.

5. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 6-30 parts of mulberry leaves, 6-30 parts of chrysanthemums, 3-12 parts of codonopsis pilosula, 10-30 parts of jujubes, 3-10 parts of ginger, 3-10 parts of licorice, 10-30 parts of astragalus, 3-12 parts of angelica, 6-15 parts of ophiopogon, 1-6 parts of kudzu root, 3-12 parts of angelica, 3-9 parts of mint, and 3-10 parts of platycodon.

6. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 16 parts of mulberry leaves, 19 parts of chrysanthemums, 8 parts of codonopsis pilosula, 19 parts of jujubes, 7 parts of ginger, 6 parts of licorice, 20 parts of astragalus, 6 parts of angelica, 10 parts of ophiopogon, 4 parts of kudzu root, 7 parts of angelica dahurica, 6 parts of mint, and 6 parts of platycodon.

7. The method for preparing the Chinese medicine composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step 1) taking raw materials by weight respectively, and soaking them in water for 1 hour; Step 2) boiling the mixture twice, adding 400-900 parts by volume of water each time, boiling the mixture over high heat for 45-55 minutes for the first time, and boiling the mixture over low heat for 35-45 minutes for the second time, and combining the decoctions obtained from the two times; Step 3) adding pharmaceutically acceptable adjuvants according to conventional processes to prepare clinically acceptable granules, pills, tablets, powders or capsules.

8. Use of the Chinese medicine composition according to any one of claims 1 to 6 in the preparation of a medicament for treating allergic rhinitis.