A medicinal composition for strengthening the body and replenishing qi and blood, and its preparation method and application

Abstract

The invention discloses a pharmaceutical composition for strengthening the body and nourishing the essence, replenishing qi and blood, and its preparation method and application, which belong to the technical field of drug preparation; including a first composition and a second composition, the first composition includes 20-35 parts of ginseng, 20-35 parts of astragalus, 10-15 parts of wolfberry, 10-15 parts of yam, 10-20 parts of prepared rehmannia, 8-15 parts of codonopsis, 8-15 parts of tuckahoe, 10-20 parts of angelica, 5-15 parts of euryale, 10-18 parts of mulberry, 10-20 parts of liquorice, 8-18 parts of dried orange peel, 5-10 parts of ginger and 10-20 parts of jujube; the second composition includes 3-8 parts of coix seeds, 3-8 parts of spiny jujube seeds, 3-10 parts of cloves and 4-10 parts of mint. The pharmaceutical composition provided by the invention can strengthen the body and nourish the essence, replenish qi and blood for middle-aged and elderly people, and can also effectively alleviate the adverse symptoms such as getting angry and allergy that occur when middle-aged and elderly people take medicine for a long time.

Description

Technical Field

[0001] The present invention belongs to the field of pharmaceutical technology, and specifically relates to a pharmaceutical composition for strengthening the body, nourishing the vital energy, and replenishing qi and blood, and a preparation method and application thereof. Background Art

[0002] As the metabolic function of middle-aged people gradually weakens and the excretion function decreases, waste remains in the body, causing blockage of Qi and blood circulation, which in turn leads to Qi and blood deficiency. Qi and blood deficiency can cause the human body to experience symptoms such as weakness and fatigue, palpitations, loss of appetite, irritability, insomnia, forgetfulness, hair loss, pain in the waist and knees, and coldness.

[0003] In addition, due to the deficiency of both Qi and blood, the immunity of middle-aged and elderly people is low, resulting in a decrease in the number and function of immune cells, which affects the body's resistance to pathogens and makes them susceptible to infection by some pathogens, such as bacteria, viruses, etc. These pathogens will further weaken the body's immunity.

[0004] In the prior art, the above problems are mainly addressed by taking health products or drugs for strengthening the body and replenishing the essence and replenishing qi and blood. However, for some special groups among the middle-aged and elderly population, such as menopausal women, people with chronic diseases but healthy liver and kidney functions, people who are very prone to getting angry, and people whose immunoglobulin G content is between 2-6g / L, these special groups have poor physical constitution and immunity. During the period of taking health products or drugs for strengthening the body and replenishing the essence and replenishing qi and blood, they are prone to adverse symptoms such as getting angry and allergies, causing additional damage to the body.

[0005] Based on this, for the above-mentioned special population, it is extremely important to provide a pharmaceutical composition that can not only play the role of strengthening the body and replenishing qi and blood, but also effectively alleviate the above-mentioned adverse symptoms. Summary of the invention

[0006] The purpose of the present invention is to provide a pharmaceutical composition for strengthening the body and replenishing qi and blood for the first time, and its preparation method and application, so as to effectively improve the metabolism of the middle-aged and elderly, reduce qi and blood stagnation, and improve the problem of qi and blood deficiency. It can effectively improve the symptoms of weakness and fatigue, palpitations, loss of appetite, irritability and insomnia, forgetfulness, hair loss, waist and knee pain, and coldness caused by qi and blood deficiency in the middle-aged and elderly, and effectively enhance the physique and immunity of the middle-aged and elderly, thereby improving the resistance to bacteria and viruses; in addition, the pharmaceutical composition provided by the present invention can effectively alleviate the adverse symptoms such as getting angry and allergies that occur when the middle-aged and elderly take the pharmaceutical composition for a long time while strengthening the body and replenishing qi and blood for the middle-aged and elderly.

[0007] The purpose of the present invention is achieved through the following technical solutions: A pharmaceutical composition for strengthening the body and replenishing qi and blood, comprising a first composition and a second composition, wherein the first composition comprises the following components in parts by weight: 20-35 parts of ginseng, 20-35 parts of astragalus, 10-15 parts of wolfberry, 10-15 parts of yam, 10-20 parts of rehmannia root, 8-15 parts of codonopsis, 8-15 parts of tuckahoe, 10-20 parts of angelica, 5-15 parts of euryale, 10-18 parts of mulberry, 10-20 parts of liquorice, 8-18 parts of dried orange peel, 5-10 parts of ginger and 10-20 parts of jujube; The second composition comprises 3-8 parts of coix seeds, 3-8 parts of spiny jujube seeds, 3-10 parts of cloves and 4-10 parts of mint.

[0008] Preferably, the first composition comprises the following components in parts by weight: 25-33 parts of ginseng, 25-30 parts of astragalus, 12-15 parts of wolfberry, 10-13 parts of yam, 12-18 parts of rehmannia root, 10-15 parts of codonopsis pilosula, 8-13 parts of poria, 15-20 parts of angelica, 8-10 parts of Euryale ferox, 12-18 parts of mulberry, 10-18 parts of licorice, 10-16 parts of tangerine peel, 5-8 parts of ginger and 13-20 parts of jujube.

[0009] Preferably, the first composition comprises the following components in parts by weight: 33 parts of ginseng, 28 parts of astragalus, 15 parts of wolfberry, 12 parts of yam, 15 parts of rehmannia root, 12 parts of codonopsis, 13 parts of poria, 16 parts of angelica, 9 parts of Euryale ferox, 15 parts of mulberry, 15 parts of licorice, 15 parts of tangerine peel, 6 parts of ginger and 18 parts of jujube.

[0010] Preferably, the second composition further comprises 3-8 portions of dandelion.

[0011] Preferably, the second composition comprises 5 parts of coix seeds, 5 parts of spiny jujube seeds, 5 parts of cloves, 6 parts of mint and 5 parts of dandelion.

[0012] In addition, in order to achieve the above-mentioned purpose, the present invention also provides a method for preparing a pharmaceutical composition for strengthening the body and replenishing qi and blood, comprising the following steps: S1. Chop the washed and dried ginseng, astragalus, wolfberry, yam, prepared rehmannia root, codonopsis, tuckahoe, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger, and jujube into small pieces according to weight to obtain pulverized medicine; S2, adding the crushed medicine and water into a container for decoction, filtering after decoction to obtain a filtrate, and then concentrating to obtain an oral solution.

[0013] Furthermore, in order to achieve the above-mentioned purpose, the present invention also provides a method for preparing a pharmaceutical composition for strengthening the body and replenishing qi and blood, comprising the following steps: S1. Chop the washed and dried ginseng, astragalus, wolfberry, yam, prepared rehmannia root, codonopsis, tuckahoe, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger, jujube, coix seed, spiny jujube seed, mint, dandelion and clove according to weight to obtain pulverized medicine; S2, adding the crushed medicine and water into a container for decoction, filtering after decoction to obtain a filtrate, and then concentrating to obtain an oral solution.

[0014] Preferably, in the preparation methods of the above two medicinal compositions for strengthening the body and replenishing qi and blood, the decoction method is as follows: Add the crushed medicine and 8-10 times the weight of water of the crushed medicine into the decoction pot. The first decoction time is 1.5-2h. After the decoction is completed, filter, take the medicine juice and keep the residue. Then, add 6-8 times the weight of water of the residue for the second decoction. The second decoction time is 1-1.5h. After the decoction is completed, filter, take the medicine juice and keep the residue. Then, add 6-8 times the weight of water of the residue for the third decoction. The third decoction time is 1-1.5h. After the decoction is completed, filter, take the medicine juice, and then combine the three decoctions to obtain the filtrate.

[0015] Furthermore, in order to achieve the above-mentioned purpose, the present invention also provides a medicinal composition for strengthening the body and replenishing qi and blood for use in preparing a medicine for improving qi and blood deficiency in the elderly.

[0016] Compared with the prior art, the present invention has the following beneficial effects: 1. The present invention provides a group of pharmaceutical compositions including ginseng, astragalus, wolfberry, Chinese yam, prepared rehmannia root, codonopsis, tuckahoe, angelica, euryale, mulberry, liquorice, tangerine peel, ginger and jujube, which can effectively play the role of strengthening the body and replenishing qi and blood, and effectively improve the immunity of middle-aged and elderly people. Specifically, in the composition, ginseng and astragalus are the main drugs, wolfberry, Chinese yam, prepared rehmannia root and codonopsis are the ministerial drugs, tuckahoe, angelica, euryale, mulberry and tangerine peel are the adjuvant drugs, ginger, jujube and liquorice are the guiding drugs, and the drugs work together to strengthen the body and replenish qi and blood.

[0017] Through the synergistic effect of the above components, the metabolism of the middle-aged and elderly can be effectively improved, the blockage of qi and blood can be reduced, and the problem of qi and blood deficiency can be improved. It can effectively improve the symptoms of weakness and fatigue, palpitations, loss of appetite, irritability and insomnia, forgetfulness, hair loss, waist and knee pain, and coldness caused by qi and blood deficiency in the middle-aged and elderly. In addition, the above drugs can also effectively enhance the physical fitness of the middle-aged and elderly, improve their immunity, and thus improve their resistance to bacteria and viruses.

[0018] Targeting some special groups among the elderly population, such as menopausal women or people with chronic diseases but healthy liver and kidney functions or people who are very prone to getting angry or middle-aged and elderly people whose immunoglobulin G content is between 2-6g / L, these special groups are relatively prone to getting angry and allergies. Based on this, the present invention further adds coix seed, jujube seed, clove and mint to the above-mentioned pharmaceutical composition. Through the synergistic effect of the four, the anti-allergic, anti-inflammatory and tranquilizing effects of the pharmaceutical composition can be effectively improved.

[0019] The present invention also adds dandelion on the basis of adding coix seed, spiny jujube seed, clove and mint, which can effectively improve the fire-reducing performance of the medicine and further improve the internal heat symptoms of middle-aged and elderly people.

[0020] The immunity of middle-aged and elderly people is relatively low, and their tolerance to drugs is relatively poor. The medicinal materials used in the present invention are all medicinal and edible medicinal materials, which can significantly reduce the toxicity of drugs to the middle-aged and elderly people. DETAILED DESCRIPTION

[0021] A medicinal composition for strengthening the body and replenishing qi and blood, comprising the following components in parts by weight: 20-35 parts of ginseng, 20-35 parts of astragalus, 10-15 parts of wolfberry, 10-15 parts of yam, 10-20 parts of rehmannia root, 8-15 parts of codonopsis pilosula, 8-15 parts of poria, 10-20 parts of angelica, 5-15 parts of Euryale ferox, 10-18 parts of mulberry, 10-20 parts of licorice, 8-18 parts of tangerine peel, 5-10 parts of ginger and 10-20 parts of jujube.

[0022] In the present invention, the compatibility relationship of the pharmaceutical composition and the functions of each component are as follows: King medicine: Ginseng: sweet, slightly bitter, slightly warm in nature, and enters the spleen, lung, heart, and kidney meridians. It has the effects of greatly replenishing vital energy, strengthening the body and promoting the production of body fluids, calming the mind and improving intelligence. It is the main medicine in the prescription, implying the root of the "Tao" in Taoism.

[0023] Astragalus: sweet in taste, warm in nature. Enters the lung and spleen meridians. It replenishes qi and raises yang, consolidates the exterior and stops sweating, promotes diuresis and reduces swelling, promotes fluid production and nourishes blood. It is the main drug together with ginseng to enhance the power of replenishing qi and consolidating the body.

[0024] Minister medicine: Lycium barbarum: sweet and neutral in nature, it enters the liver, kidney and lung meridians. It nourishes the liver and kidneys, improves the eyesight, treats dizziness, soreness of the waist and knees, and helps ginseng and astragalus to replenish the liver and kidney qi.

[0025] Chinese Yam: It is mild in nature, sweet in taste, and enters the spleen, lung, and kidney meridians. It has the effects of nourishing qi and yin, nourishing the spleen and stomach, promoting fluid production and benefiting the lungs, nourishing the kidneys and astringing essence, and cooperates with the ministerial drugs to strengthen the spleen and stomach functions. When actually using it, the outer mucus layer needs to be removed.

[0026] Rehmannia root: sweet and slightly warm in nature, it enters the liver and kidney meridians. It nourishes blood and yin, replenishes essence and fills the marrow, helps nourish yin and blood, and nourishes the liver and kidneys together with wolfberry.

[0027] Codonopsis: It is mild in nature, sweet in taste, and enters the spleen and lung meridians. It has the effects of nourishing the spleen and qi, nourishing blood and promoting body fluid, and together with yam, it strengthens the qi of the spleen and stomach.

[0028] Adjuvant: Poria cocos: It tastes sweet, light and neutral in nature. It has the functions of promoting diuresis and eliminating dampness, benefiting the spleen and stomach, and calming the mind and nerves. In addition, because the drug composition contains many tonic herbs, Poria cocos can also harmonize the various medicines in the prescription to avoid the drug composition being too greasy, which makes it difficult for the human body to bear and causes phenomena such as getting angry and allergies.

[0029] Angelica: Sweet, spicy, warm in nature, enters the liver, heart, and spleen meridians. It nourishes blood and regulates menstruation, promotes blood circulation and relieves pain, moistens the intestines and promotes bowel movements, and enhances the blood-tonifying effect of Rehmannia glutinosa.

[0030] Gorgon Fruit: Sweet, astringent, neutral in nature, mainly enters the spleen and kidney meridians. It nourishes the kidney and consolidates the essence, tonifies the spleen and stops diarrhea, removes dampness and stops leukorrhea, and assists Chinese yam and codonopsis in consolidating the spleen and kidney.

[0031] Mulberry: sweet and sour, slightly warm. It enters the liver, spleen, and kidney meridians. It nourishes yin and blood, promotes the production of body fluids and moistens dryness, helps nourish yin fluid, and replenishes yin blood together with angelica.

[0032] Tangerine peel: bitter, pungent, warm in nature. Enters the spleen, stomach, and lung meridians. Regulates qi and strengthens the spleen, dries dampness and resolves phlegm, prevents excessive stagnation of drugs, and keeps qi flowing smoothly.

[0033] Drug: Ginger: It is pungent and slightly warm in nature and enters the lung, spleen and stomach meridians. It can dispel cold, warm the middle and stop vomiting, warm the lungs and stop coughing, and guide drugs into the spleen and stomach meridians.

[0034] Jujube: sweet in taste, warm in nature, enters the spleen, stomach, and heart meridians. It replenishes the middle qi, nourishes the blood and calms the mind, harmonizes the medicinal properties, and strengthens the spleen and stomach functions.

[0035] Licorice: It is mild in nature, sweet in taste, and enters the heart, lung, spleen, and stomach meridians. It nourishes the spleen and replenishes qi, clears away heat and detoxifies, removes phlegm and relieves cough, relieves urgency and relieves pain, harmonizes various medicines, and enhances the mildness of prescriptions.

[0036] Through the synergistic effect of the above components, the metabolism of the middle-aged and elderly can be effectively improved, the blockage of qi and blood can be reduced, and the problem of qi and blood deficiency can be improved. It can effectively improve the symptoms of weakness and fatigue, palpitations, loss of appetite, irritability and insomnia, forgetfulness, hair loss, waist and knee pain, and coldness caused by qi and blood deficiency in the middle-aged and elderly. In addition, the above drugs can also effectively enhance the physical fitness of the middle-aged and elderly, improve their immunity, and thus improve their resistance to bacteria and viruses.

[0037] In summary, the pharmaceutical composition of the present invention can effectively strengthen the body's constitution and replenish qi and blood, and effectively improve the immunity of middle-aged and elderly people.

[0038] In order to further enhance the effects of the pharmaceutical composition in strengthening the body and replenishing qi and blood, as a preferred embodiment of the present invention, the dosage of each component in the pharmaceutical composition is further limited, that is, the pharmaceutical composition includes the following components in parts by weight: 25-33 parts of ginseng, 25-30 parts of astragalus, 12-15 parts of wolfberry, 10-13 parts of yam, 12-18 parts of rehmannia root, 10-15 parts of codonopsis pilosula, 8-13 parts of poria, 15-20 parts of angelica, 8-10 parts of Euryale ferox, 12-18 parts of mulberry, 10-18 parts of licorice, 10-16 parts of tangerine peel, 5-8 parts of ginger, and 13-20 parts of jujube.

[0039] In order to further enhance the effects of the pharmaceutical composition in strengthening the body and replenishing qi and blood, as a preferred embodiment of the present invention, the dosage of each component in the pharmaceutical composition is further limited, that is, the pharmaceutical composition includes the following components in parts by weight: 33 parts of ginseng, 28 parts of astragalus, 15 parts of wolfberry, 12 parts of yam, 15 parts of rehmannia root, 12 parts of codonopsis, 13 parts of poria, 16 parts of angelica, 9 parts of Euryale ferox, 15 parts of mulberry, 15 parts of licorice, 15 parts of tangerine peel, 6 parts of ginger, and 18 parts of jujube.

[0040] In order to effectively improve the allergic and internal heat phenomena caused by the pharmaceutical composition, as a preferred embodiment of the present invention, the components of the pharmaceutical composition are further limited, that is, the pharmaceutical composition also includes 3-8 parts of coix seeds, 3-8 parts of spiny jujube seeds, 3-10 parts of cloves and 4-10 parts of mint.

[0041] The medicinal composition of ginseng, astragalus, wolfberry, yam, rehmannia root, codonopsis, poria, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger and jujube is suitable for most middle-aged and elderly people. These middle-aged and elderly people all said that it can effectively improve immunity and qi and blood deficiency problems, and there are no obvious skin allergies (skin itching, redness, swelling, rash, etc.), getting angry (mouth ulcers, dry stool, abdominal distension, etc.) or insomnia (insomnia, dreaminess, restlessness, etc.).

[0042] However, there is a special group of people among the middle-aged and elderly who may experience the above-mentioned skin allergies, internal heat and other symptoms when taking the medicine. This special group mainly includes the following categories: (1) Menopausal women: The ovarian function of menopausal women gradually weakens, leading to changes in hormone levels, which in turn cause a series of reactions in the body. For example, the skin becomes more sensitive and prone to skin allergies, such as rashes and itchy skin. Secondly, during menopause, symptoms such as hot flashes, irritability, and insomnia are prone to occur, which can easily lead to internal heat. The above-mentioned drugs contain tonic drugs such as ginseng and red dates. After taking the above-mentioned drug combination, the risk of internal heat is aggravated.

[0043] (2) Middle-aged and elderly people with chronic diseases and healthy liver and kidney functions, such as chronic nephritis, will take medication for a long time to control their condition, such as hormones, immunosuppressants and other drugs. While treating chronic diseases, these drugs will also cause autoimmune damage and further reduce the body's immunity. It is understood that the immunoglobulin G content of these middle-aged and elderly people is generally lower than 6g / L, and some patients are even lower than 3g / L. The tolerance and reactivity of these patients to drugs will change accordingly. Compared with users who do not suffer from chronic diseases, these patients are more likely to have allergies, getting angry or insomnia.

[0044] (3) Middle-aged and elderly people who are prone to getting angry due to their physical constitution.

[0045] (4) People who are very susceptible to colds. These people have low immunity and their immunoglobulin G levels are generally between 2-6g / L.

[0046] It is worth noting that people with immunoglobulin G below 1.5g / L have extremely low immunity and high risks in taking medication, so it is best to do so under the guidance of a doctor.

[0047] It is worth noting that there is a certain overlap among the above four classification methods.

[0048] The above-mentioned people are prone to experience a certain degree of allergy, getting angry, or suffering from insomnia, dreaminess, and restlessness when taking the medicinal composition composed of ginseng, astragalus, wolfberry, yam, rehmannia root, codonopsis, poria, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger, and jujube.

[0049] Based on the problems of allergies, getting angry or insomnia and dreaminess in the above-mentioned special population, the present invention adds coix seed, jujube seed, clove and mint to the above-mentioned pharmaceutical composition.

[0050] Coix seeds: sweet, light, cool in nature, and enter the spleen, stomach, and lung meridians. It has the effects of clearing away heat and dampness, strengthening the spleen and relieving itching, diuresis and pus discharge, and anti-allergic. It can effectively improve patients' allergies and internal heat.

[0051] Chinese date seeds: sweet and sour in taste, neutral in nature, enter the heart, liver, and gallbladder meridians, and have the effects of nourishing the heart and liver, calming the mind, and strengthening the body. It can significantly improve the problems of poor sleep and low immunity in special groups.

[0052] Clove: Spicy, warm in nature. Enters the spleen, stomach, and kidney meridians. It has the effects of warming the middle and relieving adverse symptoms, tonifying the kidney and supporting yang, harmonizing the cold and cool drugs in the prescription, and having antibacterial, anti-inflammatory, and anti-allergic effects.

[0053] The combined effects of coix seed, yam and ginseng can effectively improve the above-mentioned problems of insomnia, dreaminess, restlessness and restlessness in the middle-aged and elderly. The synergistic effects of clove and coix seed can effectively improve allergic symptoms such as skin redness, swelling and itching.

[0054] However, long-term use of sour jujube seeds can easily cause discomfort symptoms such as itching and redness of the skin. Even with the synergistic anti-allergic effect of coix seeds and cloves, these symptoms are difficult to effectively improve.

[0055] Based on this, the present invention adds mint to the above-mentioned drug combination.

[0056] Mint: Cool in nature, spicy in taste. Enters the liver and lung meridians. It can dispel wind and heat, and improve skin itching symptoms. After adding mint, the synergistic effect of coix seed, clove and mint can significantly improve allergic problems such as itching, redness, swelling, and rash on the skin of middle-aged and elderly people.

[0057] In addition, although coix seed has a certain degree of heat-reducing performance, in actual implementation, the effect of using only coix seed is not very significant. Based on this, dandelion is added on the basis of the above components.

[0058] Dandelion: bitter and sweet in nature, cool in nature, and enters the liver and stomach meridians. It has the effects of clearing away heat and detoxifying, reducing swelling and dispersing knots, and promoting diuresis and relieving stranguria. In combination with the heat-clearing effect of coix seed, it can effectively improve the internal heat problems such as mouth sores and dry stools in the elderly. In addition, although dandelion is cold in nature, excessive use of a single dose will cause diarrhea, but the present invention can effectively improve the coldness of dandelion and the diarrhea phenomenon under the synergistic effect of ginseng, cloves, etc., and can further improve the diarrhea problem under the synergistic effect of yam, so that dandelion can play a role in clearing away heat and detoxifying, while also playing a role in replenishing vital energy, promoting body fluid and nourishing blood.

[0059] In order to further improve the allergy, internal heat and insomnia problems caused by the pharmaceutical composition to special groups of people, as a preferred embodiment of the present invention, the dosage of the pharmaceutical composition is further limited, that is, the pharmaceutical composition includes 5 parts of coix seeds, 5 parts of spiny jujube seeds, 5 parts of cloves, 6 parts of mint and 5 parts of dandelion.

[0060] In addition, in order to achieve the above-mentioned purpose, the present invention also provides a method for preparing a pharmaceutical composition for strengthening the body and replenishing qi and blood, comprising the following steps: S1. Chop the washed and dried ginseng, astragalus, wolfberry, yam, prepared rehmannia root, codonopsis, tuckahoe, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger, and jujube into small pieces according to weight to obtain pulverized medicine; S2, adding the crushed medicine and water into a container for decoction, filtering and centrifuging after the decoction to obtain a filtrate, and then concentrating to obtain an oral solution.

[0061] In the present invention, the pharmaceutical composition is crushed, decocted and then prepared into an oral liquid. The preparation method is simple, and the pharmaceutical composition is prepared into an oral liquid, which is more convenient to use.

[0062] Furthermore, in order to achieve the above-mentioned purpose, the present invention also provides a method for preparing a pharmaceutical composition for strengthening the body and replenishing qi and blood, comprising the following steps: S1. Chop the washed and dried ginseng, astragalus, wolfberry, yam, prepared rehmannia root, codonopsis, tuckahoe, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger, jujube, coix seed, spiny jujube seed, mint, dandelion and clove according to weight to obtain pulverized medicine; S2, adding the crushed medicine and water into a container for decoction, filtering and centrifuging after the decoction to obtain a filtrate, and then concentrating to obtain an oral solution.

[0063] In order to further increase the content of effective components in the pharmaceutical composition, as a preferred embodiment of the present invention, the decoction method is further limited, that is, in the preparation methods of the above two pharmaceutical compositions for strengthening the body and replenishing qi and blood, the decoction method is as follows: Add the crushed medicine and 8-10 times the weight of water of the crushed medicine into the decoction pot. The first decoction time is 1.5-2h. After the decoction is completed, filter, take the medicine juice and keep the residue. Then, add 6-8 times the weight of water of the residue for the second decoction. The second decoction time is 1-1.5h. After the decoction is completed, filter, take the medicine juice and keep the residue. Then, add 6-8 times the weight of water of the residue for the third decoction. The third decoction time is 1-1.5h. After the decoction is completed, filter, take the medicine juice, and then combine the three decoctions to obtain the filtrate.

[0064] Next, the preparation of the pharmaceutical composition of the present invention is described in detail through specific examples.

[0065] Example 1 S1, 30 parts of ginseng, 30 parts of astragalus, 13 parts of wolfberry, 13 parts of yam, 16 parts of prepared rehmannia, 12 parts of codonopsis, 14 parts of tuckahoe, 18 parts of angelica, 10 parts of Euryale, 14 parts of mulberry, 13 parts of liquorice, 14 parts of tangerine peel, 7 parts of ginger and 18 parts of jujube are chopped to obtain a crushed drug passing through a 150-200 mesh sieve; S2, add the crushed medicine and water together to a container for decoction, specifically, add the crushed medicine and 10 times the weight of the crushed medicine into a decoction pot, heat to 90 degrees Celsius for decoction, the first decoction time is 2 hours, after the decoction is completed, filter, take the medicine juice and leave the medicine residue, then add 8 times the weight of the medicine residue for the second decoction, heat to 90 degrees Celsius for decoction, the second decoction time is 1.5 hours, after the decoction is completed, filter, take the medicine juice and leave the medicine residue, then add 8 times the weight of the medicine residue for the third decoction, heat to 90 degrees Celsius for decoction, the third decoction time is 1.5 hours, after the decoction is completed, filter, take the medicine juice, then combine the three decoctions to obtain a filtrate. Then, perform rotary evaporation concentration at 65 degrees Celsius, and the soluble solid content in the obtained concentrate is 40%; then add sorbic acid in an amount of 0.18% (wt) to obtain an oral solution.

[0066] Example 2 Compared with Example 1, the weight fractions of each component in step S1 were adjusted, and the weight fractions of each component after adjustment were as follows: 33 parts of ginseng, 28 parts of astragalus, 15 parts of wolfberry, 12 parts of yam, 15 parts of rehmannia root, 12 parts of codonopsis, 13 parts of poria, 16 parts of angelica, 9 parts of Euryale ferox, 15 parts of mulberry, 15 parts of licorice, 15 parts of tangerine peel, 6 parts of ginger, and 18 parts of jujube.

[0067] The remaining steps and parameters are the same as in Example 1.

[0068] Example 3 Compared with Example 1, 6 parts of coix seeds, 5 parts of spiny jujube seeds, 4 parts of cloves and 5 parts of mint were added in step S1.

[0069] Example 4 Compared with Example 1, 5 parts of coix seeds, 5 parts of spiny jujube seeds, 5 parts of cloves, 6 parts of mints and 5 parts of dandelions are added in step S1, and the remaining steps and parameters are the same as Example 1.

[0070] Comparative Example 1 Compared with Example 1, the weight portion of ginseng in step S1 is changed to 45 portions, and the other components and preparation method remain unchanged.

[0071] Comparative Example 2 Compared with Example 4, cloves and yam are not added.

[0072] Comparative Example 3 Compared with Example 4, no Poria cocos was added.

[0073] Comparative Example 4 Compared with Example 4, mint is not added.

[0074] Experimental example 1. Drug toxicity experiments.

[0075] 32 mice were taken and divided into 8 groups, with half male and half female mice in each group. Afterwards, the 8 groups of mice were orally gavaged with the oral solution of Example 1-4 and Comparative Example 1-4 at a dose of 0.4 ml / kg, 3 times a day, and observed for 20 consecutive days.

[0076] The observation revealed no death or abnormal toxic reactions in the experimental mice.

[0077] After the test, the mice were dissected and their liver, kidney, spleen, heart, lung, stomach, intestine and other major organs were observed, and no abnormal changes were found. The sample is non-toxic.

[0078] 2. The medicine has the effect of strengthening the body, replenishing qi and blood.

[0079] A total of 135 test subjects, aged between 45 and 72 years old, were selected and divided equally into 9 groups, with no less than 5 males and 5 females in each group.

[0080] Tester selection criteria: People with any of the following symptoms: Symptoms include weakness and fatigue, palpitations, loss of appetite, irritability and insomnia, forgetfulness, hair loss, pain in the waist and knees, coldness, irritability, bad temper, hot flashes, and susceptibility to colds.

[0081] Before the tester is treated, all current symptoms of each tester are recorded.

[0082] Tester exclusion criteria: ① Patients who are clearly aware of being allergic to any component of the drug composition; ② Patients with serious primary diseases such as cardiovascular, cerebrovascular, liver, kidney, digestive tract, and hematopoietic system, and mental illness; ③ Those whose wounds have not fully recovered after surgery; those who currently have colds, diarrhea, internal heat, or allergies; ④ Pregnant women; 5. Those who have taken drugs related to the pharmaceutical composition of the present invention within 30 days; ⑥ Middle-aged and elderly people whose immunoglobulin G levels are lower than 1.5g / L.

[0083] Treatment: 9 groups of testers took the oral liquids in Examples 1-4, Comparative Examples 1-4 and Tong Ren Tang Yu Pin respectively for 3 months. The oral liquids in Examples 1-4 and Comparative Examples 1-4 were taken three times a day, 10 ml each time, and Tong Ren Tang Yu Pin was taken according to the instructions.

[0084] If you experience skin allergies such as itching, redness and swelling, oral ulcers, dry stools and other symptoms of internal heat, or diarrhea and other obvious discomfort (such discomfort does not include cold symptoms) during medication, you should stop taking the medicine. If you catch a cold during medication, you should stop taking the medicine. After the cold is cured, continue to take the same medicine as before the cold.

[0085] After three months, the test subjects will be revisited to see if their condition has improved, to prove the efficacy of the drug. The efficacy of the drug is divided into the following three standards: ① Significantly effective: The symptoms previously recorded by the testers have been significantly improved; ② Partially effective: Some of the symptoms previously recorded by the tester have improved, while others have not improved significantly; ③Ineffective: No improvement in all symptoms.

[0086] Among them, the effective number of people = the sum of the number of effective people and the number of partially effective people.

[0087] Three months later, through a return visit, the situation of the 9 groups of testers was recorded in Table 1: Table 1 It is worth noting that the number of people suspended in Table 1 only refers to the number of people who were suspended due to skin allergies such as itchy and redness, or symptoms of internal heat such as oral ulcers or dry stools, or medication reasons such as diarrhea, and does not include the number of people who were suspended due to colds.

[0088] From Table 1, we can see that: The effective number of people in Examples 1-4 is not less than 13 people, which shows that the pharmaceutical composition of the present invention can effectively improve various symptoms caused by deficiency of Qi and blood and low immunity in middle-aged and elderly people.

[0089] In Example 1: The suspended person was a patient with chronic nephritis for 4 years (normal liver and kidney functions, immunoglobulin G content of 4.5g / L), and the main symptoms were skin allergies such as skin redness, swelling, and itching.

[0090] In Example 3, the suspended personnel are menopausal women who are often prone to colds (the immunoglobulin G content is 5.6g / L), and the main symptoms are oral ulcers, dry stools and other internal heat symptoms. In addition, they often have symptoms of insomnia and dreaminess before taking the medicine.

[0091] After the discomfort symptoms of the two suspended personnel in Example 1 and Example 3 completely disappeared, they all took the oral liquid of Example 4. During the period of taking the oral liquid, the suspended personnel in Example 1 had no obvious allergic phenomenon, the suspended personnel in Example 3 had no obvious above-mentioned internal heat phenomenon, and the insomnia and dreaminess phenomenon was significantly improved.

[0092] When the two suspended personnel were subsequently interviewed, one said that the effect was remarkable and the other said that the effect was partially remarkable.

[0093] From Table 1 and the above analysis, we can see that: The pharmaceutical composition in Examples 1-2 is suitable for middle-aged and elderly people who are not special populations. These middle-aged and elderly people are not prone to allergies, internal heat and other discomfort symptoms. Compared with Examples 1-2, Example 3 adds anti-allergic drugs to improve the anti-allergic effect, which can target special populations that are more susceptible to allergies, but its overall internal heat-reducing performance is poor. For some menopausal women in this population and people who are very prone to internal heat, there is still an obvious internal heat problem. Example 4 adds dandelion on the basis of Example 3, which can effectively improve the problem of insufficient internal heat-reducing ability in Example 3.

[0094] In Comparative Example 1, due to the increase in ginseng content, the content of tonic drugs increased, which destroyed the balance of the prescription and caused the drugs to easily get angry. The two suspended personnel in Comparative Example 1 both had the phenomenon of getting angry, one of whom was a menopausal woman (the content of immunoglobulin G was greater than 8.5g / L), and the other was a special population that was very prone to getting angry (the content of immunoglobulin G was greater than 8.5g / L). After the symptoms of getting angry of the two suspended personnel completely disappeared, they took the oral liquid in Example 4, and the two suspended personnel did not have obvious symptoms of getting angry. During the follow-up visit, one of the two suspended personnel said that it was effective, and the other said that it was partially effective.

[0095] From this we can see that when a certain component of a drug increases and disrupts the balance of the drug, even middle-aged and elderly people with relatively good immunity will still suffer from the phenomenon of getting a sore throat.

[0096] In Comparative Example 2, 2 of the suspended personnel had diarrhea in non-special populations (the immunoglobulin G levels of both people were higher than 8.5g / L), and 1 menopausal woman (immunoglobulin G level was 2g / L, with low immunity) developed skin itching.

[0097] In the pharmaceutical composition, dandelion is likely to cause diarrhea and indigestion. If yam and clove are not added to the pharmaceutical composition, it is difficult to balance the drugs, resulting in difficulty in solving the diarrhea problem.

[0098] Cloves themselves have a certain degree of anti-allergic effect. If they are not added, the anti-allergic effect will be aggravated and weakened.

[0099] After the symptoms of the three suspended personnel completely disappeared, after taking the oral liquid in Example 4, the two non-special populations did not show obvious diarrhea symptoms. Although the itching symptoms of the menopausal women were alleviated after taking it, mild symptoms still occurred. Considering that the user has low immunity and is not suitable for the drug, she was withdrawn from the experiment.

[0100] During the follow-up visit, the two suspended subjects who did not withdraw from the experiment both expressed that the treatment was significantly effective.

[0101] In comparative example 3, the three suspended personnel all had problems with internal heat, such as oral ulcers or dry stools. In this comparative example, Poria cocos has the effect of calming the nerves and balancing other medicines to prevent the medicines from being too greasy. If Poria cocos is not added, the medicines are very likely to cause internal heat.

[0102] After the internal heat symptoms completely disappeared, the person suffering from internal heat took the oral liquid in Example 4, and no obvious internal heat symptoms appeared.

[0103] During the follow-up visit, 2 of the 3 people mentioned above said that the effect was remarkable and 1 said that the effect was partially remarkable.

[0104] In Comparative Example 4, the suspended person had skin allergies and symptoms of internal heat such as dry mouth and tongue (the person was very prone to internal heat and the immunoglobulin G level was 5.1g / L).

[0105] After the symptoms completely disappeared, the patient took the oral solution in Example 4, and no obvious allergic or internal heat symptoms were observed.

[0106] In the Tong Ren Tang Imperial Products experimental group, the suspended people (people who are very prone to getting angry) showed signs of getting angry.

[0107] After the internal heat symptoms completely disappeared, the oral liquid in Example 4 was taken, and no obvious internal heat symptoms appeared.

[0108] In addition, during the follow-up visit, the symptoms of insomnia, dreaminess and restlessness of 5 subjects in Examples 1 and 2 did not improve significantly. These 5 subjects were asked to take the oral liquid in Example 4 for 3 months after the follow-up visit. After 3 months, all 5 subjects indicated that their insomnia symptoms had improved to a certain extent.

[0109] 3. The drug has the effect of reducing fever and relieving allergies.

[0110] On the basis of the tester selection criteria and exclusion criteria in point 2, 45 middle-aged and elderly people who meet the special population (among whom, one person meets at least one or more points in the special population, such as being middle-aged and elderly people in menopause and suffering from chronic diseases at the same time) were selected and divided into three groups. They took Example 1, Example 4 and Tong Ren Tang Imperial Products respectively, and the taking criteria referred to the above point 2.

[0111] If you experience skin allergies such as itching, redness, and swelling, oral ulcers, dry stools, or diarrhea, or other obvious discomfort, stop taking the medicine. If you catch a cold while taking the medicine, stop taking the medicine. After the cold is cured, continue taking the same medicine as before the cold.

[0112] Three months later, through a return visit, the conditions of the three groups of testers were recorded in Table 2. The test standards in Table 2 refer to Table 1.

[0113] Table 2 Number of people with significant effect (persons) Partially effective number of people Invalid number of people (persons) Number of people suspended due to discomfort (persons) Example 1 3 5 2 5 Example 2 4 9 1 1 Tong Ren Tang Royal Products 3 6 2 4 It is worth noting that the number of people suspended in Table 2 only refers to the number of people who were suspended due to skin allergies such as itchy and redness, or symptoms of internal heat such as oral ulcers or dry stools, or medication reasons such as diarrhea, and does not include the number of people who were suspended due to colds.

[0114] Table 2 shows that among the five suspended personnel in Example 1, one had skin allergies such as itchy or reddish swelling, three had oral ulcers or dry stools and other internal heat symptoms, and one had diarrhea. The suspended personnel in Example 2 had severe rashes on their skin; among the four suspended personnel in Tongrentang Yupin, one had diarrhea and indigestion, one had skin allergies such as itchy or reddish swelling, and two had oral ulcers or dry stools and other internal heat symptoms.

[0115] After the above symptoms of the people in Table 2 completely disappeared, they took the oral liquid in Example 4. Except for the patient in Example 2 who still had rash symptoms, the other patients did not obviously show the previous symptoms. When the patient in Example 2 was subsequently treated in the hospital, the doctor pointed out that he might be allergic to a component in the formula and recommended not to use it anymore.

[0116] It can be seen from the above records that the oral liquid in Example 4 can significantly improve skin allergies such as itching, redness and swelling, or symptoms of internal heat such as oral ulcers or dry stools, or diarrhea and other symptoms in special populations.

[0117] It is worth noting that the experimental population in Table 1 only needs to meet the tester selection criteria and exclusion criteria, and does not focus on distinguishing special populations, so the special populations included are relatively small. The special populations in Table 2 are divided according to the medication symptoms and physical conditions of the suspended personnel in Table 1.

Claims

1. A pharmaceutical composition for strengthening the body and replenishing qi and blood, characterized in that: The invention comprises a first composition and a second composition, wherein the first composition comprises the following components in parts by weight: 20-35 parts of ginseng, 20-35 parts of astragalus, 10-15 parts of wolfberry, 10-15 parts of yam, 10-20 parts of rehmannia root, 8-15 parts of codonopsis, 8-15 parts of tuckahoe, 10-20 parts of angelica, 5-15 parts of euryale, 10-18 parts of mulberry, 10-20 parts of liquorice, 8-18 parts of dried orange peel, 5-10 parts of ginger and 10-20 parts of jujube; The second composition comprises 3-8 parts of coix seeds, 3-8 parts of spiny jujube seeds, 3-10 parts of cloves and 4-10 parts of mint.

2. A pharmaceutical composition for strengthening the body and replenishing qi and blood according to claim 1, characterized in that: The first composition comprises the following components in parts by weight: 25-33 parts of ginseng, 25-30 parts of astragalus, 12-15 parts of wolfberry, 10-13 parts of yam, 12-18 parts of rehmannia root, 10-15 parts of codonopsis pilosula, 8-13 parts of poria, 15-20 parts of angelica, 8-10 parts of Euryale ferox, 12-18 parts of mulberry, 10-18 parts of licorice, 10-16 parts of tangerine peel, 5-8 parts of ginger and 13-20 parts of jujube.

3. A pharmaceutical composition for strengthening the body and replenishing qi and blood according to claim 1, characterized in that: The first composition comprises the following components in parts by weight: 33 parts of ginseng, 28 parts of astragalus, 15 parts of wolfberry, 12 parts of yam, 15 parts of rehmannia root, 12 parts of codonopsis, 13 parts of poria, 16 parts of angelica, 9 parts of Euryale ferox, 15 parts of mulberry, 15 parts of licorice, 15 parts of tangerine peel, 6 parts of ginger and 18 parts of jujube.

4. A pharmaceutical composition for strengthening the body and replenishing qi and blood according to any one of claims 1 to 3, characterized in that: The second composition further comprises 3-8 parts of dandelion.

5. A pharmaceutical composition for strengthening the body and replenishing qi and blood according to claim 4, characterized in that: The second composition includes 5 parts of coix seeds, 5 parts of spiny jujube seeds, 5 parts of cloves, 6 parts of mint and 5 parts of dandelion.

6. The method for preparing a medicinal composition for strengthening the body and replenishing qi and blood according to claim 1, characterized in that: The preparation method of the first composition comprises the following steps: S1. Chop the washed and dried ginseng, astragalus, wolfberry, yam, prepared rehmannia root, codonopsis, tuckahoe, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger, and jujube into small pieces according to weight to obtain pulverized medicine; S2, adding the crushed medicine and water into a container for decoction, filtering after decoction to obtain a filtrate, and then concentrating to obtain an oral solution.

7. The method for preparing a medicinal composition for strengthening the constitution and replenishing qi and blood according to claim 4, characterized in that: The steps include: S1. Chop the washed and dried ginseng, astragalus, wolfberry, yam, prepared rehmannia root, codonopsis, tuckahoe, angelica, Euryale ferox, mulberry, licorice, tangerine peel, ginger, jujube, coix seed, spiny jujube seed, mint, dandelion and clove according to weight to obtain pulverized medicine; S2, adding the crushed medicine and water into a container for decoction, filtering after decoction to obtain a filtrate, and then concentrating to obtain an oral solution.

8. A method for preparing a pharmaceutical composition for strengthening the body and replenishing qi and blood according to claim 6 or 7, characterized in that: The decoction method is as follows: Add the crushed medicine and 8-10 times the weight of water of the crushed medicine into the decoction pot. The first decoction time is 1.5-2h. After the decoction is completed, filter, take the medicine juice and keep the residue. Then, add 6-8 times the weight of water of the residue for the second decoction. The second decoction time is 1-1.5h. After the decoction is completed, filter, take the medicine juice and keep the residue. Then, add 6-8 times the weight of water of the residue for the third decoction. The third decoction time is 1-1.5h. After the decoction is completed, filter, take the medicine juice, and then combine the three decoctions to obtain the filtrate.

9. Use of a pharmaceutical composition for strengthening the body and replenishing qi and blood according to any one of claims 1 to 5 in preparing a medicine for improving qi and blood deficiency in the elderly.

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