Laminated film material for soft infusion bag and preparation method of laminated film material

Abstract

The invention relates to the technical field of film materials, and provides a laminated film material for an infusion soft bag, which comprises an outer layer material, a laminated layer material and an inner layer material, the laminated material is formed by alternately laminating A layers and B layers; the material of the layer A is a composition A, and the material of the layer B is a composition B; the composition A comprises the following components: homo-polypropylene, a cycloolefin copolymer and high-density polyethylene; and the composition B comprises the following components: co-polypropylene, a styrene block copolymer and linear low-density polyethylene. According to the laminated film material for the soft infusion bag and the preparation method of the laminated film material, the prepared laminated film material has good gas barrier property and low-temperature toughness.

Description

Technical Field

[0001] The present invention relates to the technical field of film materials, and in particular to a laminated film material for an infusion soft bag and a preparation method thereof. Background Art

[0002] At present, the materials used for large infusion soft bags in China are generally three-layer or five-layer co-extruded infusion films. The three-layer co-extruded infusion film is mainly made of polypropylene and is formed by a co-extrusion bottom-blowing water-cooled film blowing process. The three-layer co-extruded infusion film can meet the basic requirements of infusion containers: good drug compatibility, water vapor and oxygen barrier properties, good heat sealing strength, certain printing and scratch resistance, etc. The three-layer co-extruded infusion film is divided into an inner layer, a middle layer, and an outer layer. The three-layer structure has different main functions for the infusion film. The inner layer has good drug compatibility and heat sealing performance, the outer layer has good printing and scratch resistance, the middle layer needs good gas barrier properties, and supports the infusion film, and has good mechanical properties.

[0003] As the main material of the three-layer co-extruded infusion film, polypropylene has the advantages of excellent mechanical properties, good water vapor barrier properties, good chemical stability, non-toxicity, rich raw material sources, and low price. However, polypropylene is a semi-crystalline polymer with disadvantages such as poor transparency and poor low-temperature toughness. In order to improve the transparency and low-temperature toughness of the infusion film, it is necessary to blend and modify the polypropylene in the infusion film. Styrene-based thermoplastic elastomers (such as hydrogenated styrene-butadiene block copolymers) can greatly improve the transparency and low-temperature toughness of polypropylene, so the infusion film contains a certain proportion of such thermoplastic elastomers. Although the addition of thermoplastic elastomers can improve the transparency and low-temperature toughness of polypropylene infusion films, it will reduce the water vapor barrier properties of the infusion film and increase the cost of the infusion film. Therefore, the barrier properties and low-temperature toughness of the infusion film are a contradiction. How to balance and even improve the water vapor barrier properties and low-temperature toughness of the infusion film at the same time has always been a difficulty in the industry.

[0004] Application Contents

[0005] The object of the present invention is to provide a laminated film material for an infusion soft bag and a preparation method thereof. The prepared laminated film material has good gas barrier properties and low-temperature toughness.

[0006] The embodiments of the present invention are realized by the following technical scheme: the laminated film material for the soft infusion bag of the present invention comprises an outer layer material, a laminated layer material, and an inner layer material; the laminated layer material is formed by alternatingly laminating layers A and B; the material of the A layer is composition A, and the material of the B layer is composition B; the components of the composition A include homopolypropylene, cycloolefin copolymer, and high-density polyethylene; the components of the composition B include copolymer polypropylene, styrene block copolymer, and linear low-density polyethylene.

[0007] Composition A is a hard barrier material with good gas barrier properties; composition B is a soft material with excellent low-temperature toughness. The hard and soft materials are alternately stacked using micro-nano stacking technology. The thickness of each layer is as low as micron level. Micron-level stacking enhances the barrier properties (compared with a single A / B layer, the gas needs to continuously alternately diffuse between the barrier material and the soft material, and needs to pass through more interface layers, so the barrier effect is enhanced); the soft material has good low-temperature toughness, and the stacking structure protects the hard barrier material well, preventing the hard barrier material from being damaged by low-temperature impact and affecting the failure of the overall film material.

[0008] The main material of composition A is homopolymer polypropylene, which has good gas barrier properties and good compatibility with the outer layer material. The adhesion strength between the two layers is good, which avoids stratification. Cyclic olefin copolymer materials and high-density polyethylene further improve the barrier performance. High-density polyethylene promotes the compatibility of cyclic olefin copolymer and polypropylene, so that the overall mechanical properties of composition A are good. The main material of composition B is styrene copolymer elastomer, which makes the component material have good low-temperature toughness, good compatibility with the inner layer material, and high adhesion strength. The addition of partial copolymer polypropylene improves the compatibility of composition B and composition A, which is beneficial to the partial entanglement of the interface layer molecules of the two layers, so that the interface layer can play a better role. Linear low-density polyethylene further improves the low-temperature mechanical properties of composition B.

[0009] Furthermore, in terms of weight, the composition A contains 60-75 parts of homopolypropylene, 20-30 parts of cycloolefin copolymer, and 5-10 parts of high-density polyethylene; the composition B contains 10-30 parts of copolymerized polypropylene, 60-70 parts of styrene block copolymer, and 10-20 parts of linear low-density polyethylene. The density of the composition A is 0.890-0.980 g / cm 3 The melt flow rate of the plastic is 1.5-5 g / 10 min at 230°C and 2.16 kg. The density of composition B is 0.850-0.910 g / cm 3 , under the test conditions of 230℃ and 2.16kg, the plastic melt flow rate is 2-6g / 10min.

[0010] Furthermore, the number of alternations between the A layer and the B layer is 2 n , where n is 4-10.

[0011] Furthermore, the outer layer material is composition C, and the components of composition C include 75-90 parts of homopolymer polypropylene and 10-25 parts of styrene block copolymer by weight. The density of the outer layer material is 0.880-0.950 g / cm 3 , under the test conditions of 230℃ and 2.16kg, the plastic melt flow rate is 2-7g / 10min.

[0012] Furthermore, the inner layer material is composition D, and the components of composition D include 65-80 parts of copolymerized polypropylene, 5-15 parts of polyolefin elastomer, and 15-30 parts of styrene block copolymer by weight. The density of the inner layer material is 0.880-0.930 g / cm 3 , under the test conditions of 230℃ and 2.16kg, the plastic melt flow rate is 4-8g / 10min.

[0013] Furthermore, in terms of weight, the outer layer material is 10-30 parts, the laminated layer material is 55-75 parts, and the inner layer material is 10-20 parts.

[0014] Furthermore, the thickness of the outer layer material is 15-75 μm, the thickness of the laminated layer material is 80-180 μm, and the thickness of the inner layer is 15-50 μm; the single layer thickness of the composition A and the composition B are both 1-5 μm.

[0015] The present invention also provides a method for preparing the laminated film material for the infusion soft bag, comprising the following steps:

[0016] (1) using a mixer and a twin-screw extruder to prepare composition A and composition B respectively;

[0017] (2) Composition A and composition B are respectively fed into different extruders at the same time, and the materials plasticized by the extruders are simultaneously fed into a manifold to form a laminated material of composition A / composition B in the manifold. After the laminated material passes through a multiplier, an alternating laminated material is formed, i.e., a laminated layer material;

[0018] (3) using a mixer and a twin-screw extruder to prepare the inner layer material and the outer layer material respectively;

[0019] (4) The plasticized laminated layer material, outer layer material and inner layer material are fed into a film blowing die head together, and the film is blown and cooled to obtain a laminated film material.

[0020] Furthermore, in step (1), step (2) and step (3), the temperature of zones 1 and 2 of the extruder is 120-170°C, the temperature of zones 3 to 5 is 180-200°C, the temperature of zones 6 to 10 is 200-230°C, the temperature of the confluence and multiplier is 220-240°C; the temperature of the die head in step (4) is 220-240°C.

[0021] The technical solution of the embodiment of the present invention has at least the following advantages and beneficial effects: the laminated film material for the infusion soft bag of the present invention and the preparation method thereof utilize micro-nano lamination technology to alternately laminate two materials with different properties, and through the design of the proportion of each component and the use of the layer interface effect, the two contradictory properties of the barrier performance and low-temperature toughness of the entire film material are well balanced, and the film has both good gas barrier properties and low-temperature toughness. DETAILED DESCRIPTION

[0022] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0023] Examples 1-3

[0024] Examples 1-3 all provide laminated film materials for infusion soft bags and preparation methods thereof, wherein the operation steps of Examples 1-3 are the same, and the only difference is the content of the components. The specific steps are as follows, and the content of the components of each embodiment is shown in Table 1 below. The total thickness of the prepared laminated film material is 200 microns. In addition, since composition A and composition B are alternately overlapped multiple times, the content of each component in composition A and composition B recorded in Table 1 refers to the single layer content, not the total content (same as Tables 2-3).

[0025] (1) using a high-speed mixer and a twin-screw extruder to prepare composition A, composition B, composition C, and composition D respectively; the temperature of the first and second zones of the extruder is 150° C., the temperature of the third to fifth zones is 180° C., the temperature of the sixth to tenth zones is 200° C., and the temperature of the combiner and multiplier is 220° C.;

[0026] (2) Composition A and composition B are respectively fed into different extruders at the same time, and the materials plasticized by the extruders are simultaneously fed into a manifold to form a laminated material of composition A / composition B in the manifold. After the laminated material passes through a multiplier, an alternating laminated material is formed, i.e., a laminated layer material; the temperature of the first and second zones of the extruder is 150° C., the temperature of the third to fifth zones is 180° C., the temperature of the sixth to tenth zones is 200° C., and the temperature of the manifold and the multiplier is 220° C.;

[0027] (3) simultaneously feeding composition C and composition D into an extruder respectively, and melting and plasticizing in the extruder to form an inner layer material and an outer layer material; the temperature of the first and second zones of the extruder is 150° C., the temperature of the third to fifth zones is 180° C., the temperature of the sixth to tenth zones is 200° C., and the temperature of the confluence and multiplier is 220° C.;

[0028] (4) The plasticized laminated layer material, outer layer material and inner layer material are fed into a film blowing die head together, and the film is blown and cooled to obtain a laminated film material. The die head temperature is 220°C.

[0029] Table 1 Components and contents in Examples 1-3

[0030]

[0031] Comparative Example 1

[0032] Comparative Example 1 discloses a membrane material, the components and contents of which are shown in Table 2 below, and the steps for preparing the membrane material are as follows:

[0033] (1) using a high-speed mixer and a twin-screw extruder to prepare an inner layer material, an outer layer material, and an intermediate layer material respectively;

[0034] (2) The inner layer material, the outer layer material, and the middle layer material are respectively fed into an extruder, melted and plasticized in the extruder, and then fed into a co-extrusion film blowing die head, and the film material is obtained after film blowing and cooling.

[0035] Table 2 Components and contents in Comparative Example 1

[0036]

[0037] Comparative Example 2

[0038] Comparative Example 2 is a laminated film material, and its preparation method, components and contents are the same as those of the laminated film material in Example 2, except that the composition A is completely replaced by the composition B.

[0039] Comparative Examples 3-4

[0040] Comparative Example 3-4 is a laminated film material, and its preparation method is consistent with that of Example 1, except for the components and their contents. The components and their contents of Comparative Example 3-4 are shown in Table 3 below.

[0041] Table 3 Components and contents in Comparative Examples 3-4

[0042]

[0043] Experimental example

[0044] The materials prepared in Examples 1-3 and Comparative Examples 1-4 were subjected to oxygen permeability and low-temperature tensile impact tests, and the test methods were as follows:

[0045] Water vapor transmission rate: measured at 38°C and 90% relative humidity according to the first method of water vapor transmission rate measurement (YBB00092003-2015).

[0046] Oxygen permeation rate: measured at 23°C and 50% relative humidity according to the first method of gas permeation rate measurement (YBB00082003-2015).

[0047] Tensile impact strength: tested at 0℃, measured according to the test method for tensile impact properties of plastics (GB / T13525-1992).

[0048] The test results are shown in Table 4 below.

[0049] Table 4 Test results of Examples 1-3 and Comparative Examples 1-4

[0050]

[0051] It can be seen from the experimental data in Table 4 that the laminated film material of the present application has low water vapor permeability and oxygen permeability, and high tensile impact strength under low temperature conditions.

[0052] From the comparison of Example 1 and Comparative Example 1, it can be seen that when a stacking layer is contained, the water vapor permeability and oxygen permeability of the film material are reduced, and the low-temperature tensile impact strength is improved; from the comparison of Example 2 and Comparative Example 2, it can be seen that the film material is made by stacking hard materials and soft materials, and the water vapor permeability and oxygen permeability of the film material are reduced, and the low-temperature tensile impact strength is improved compared with the film material stacked with the same composition; from the comparison of Examples 1-3 and Comparative Examples 3-4, it can be seen that when the components and contents of the present invention and the number of stacking times are used, the barrier properties and low-temperature toughness of the film material are better.

[0053] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A laminated film material for an infusion soft bag, characterized in that: It comprises an outer layer material, a laminated layer material, and an inner layer material; the laminated layer material is formed by alternately laminating layers A and B; the material of the A layer is a composition A, and the material of the B layer is a composition B; The components of the composition A include homopolypropylene, cycloolefin copolymer, and high-density polyethylene; The components of the composition B include copolymerized polypropylene, styrene block copolymer and linear low-density polyethylene.

2. The laminated film material for infusion soft bag according to claim 1, characterized in that: In terms of weight, the composition A contains 60-75 parts of homopolypropylene, 20-30 parts of cycloolefin copolymer, and 5-10 parts of high-density polyethylene; the composition B contains 10-30 parts of copolymer polypropylene, 60-70 parts of styrene block copolymer, and 10-20 parts of linear low-density polyethylene.

3. The laminated film material for infusion soft bag according to claim 1, characterized in that: The number of alternations between the A layer and the B layer is 2 n , where n is 4-10.

4. The laminated film material for infusion soft bag according to claim 1, characterized in that: The outer layer material is composition C, and the components of composition C include 75-90 parts of homopolypropylene and 10-25 parts of styrene block copolymer by weight.

5. The laminated film material for soft infusion bag according to claim 1, characterized in that: The inner layer material is composition D, and the components of composition D include 65-80 parts of copolymerized polypropylene, 5-15 parts of polyolefin elastomer, and 15-30 parts of styrene block copolymer by weight.

6. The laminated film material for soft infusion bag according to claim 1, characterized in that: By weight, the outer layer material is 10-30 parts, the laminated layer material is 55-75 parts, and the inner layer material is 10-20 parts.

7. The laminated film material for a soft infusion bag according to claim 1, characterized in that: The thickness of the outer layer material is 15-75 μm, the thickness of the laminated layer material is 80-180 μm, and the thickness of the inner layer is 15-50 μm; the single layer thickness of the composition A and the composition B are both 1-5 μm.

8. The method for preparing a laminated film material for an infusion soft bag according to any one of claims 1 to 7, characterized in that: The steps are as follows: (1) using a high-speed mixer and a twin-screw extruder to prepare composition A and composition B respectively; (2) Composition A and composition B are respectively fed into different extruders at the same time, and the materials plasticized by the extruders are simultaneously fed into a manifold to form a laminated material of composition A / composition B in the manifold. After the laminated material passes through a multiplier, an alternating laminated material is formed, i.e., a laminated layer material; (3) using a high-speed mixer and a twin-screw extruder to prepare the inner layer material and the outer layer material respectively; (4) The plasticized laminated layer material, outer layer material and inner layer material are fed into a film blowing die head together, and the film is blown and cooled to obtain a laminated film material.

9. The method for preparing the laminated film material for the infusion soft bag according to claim 8, characterized in that: In step (1), step (2) and step (3), the temperature of the extruder zone 1 and zone 2 is 120-170°C, the temperature of the zone 3 to zone 5 is 180-200°C, the temperature of the zone 6 to zone 10 is 200-230°C, and the temperature of the confluence and multiplier is 220-240°C; the temperature of the die head in step (4) is 220-240°C.

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