A fully automatic chemiluminescence analyzer

Abstract

The present invention relates to a fully automatic chemiluminescence analyzer, including a frame, the frame is provided with a bottom plate, the bottom plate is provided with a first guide rail penetrating the frame, a reaction module is slidably connected on the first guide rail, the end face of the reaction module away from the bottom plate is provided with a reaction chamber, a mounting groove is provided in the reaction chamber, and a reagent strip is clamped; the frame is provided with a second guide rail toward the bottom plate, a sampling transfer module is slidably connected on the second guide rail, the sampling transfer module includes a sampling bracket, a liquid transfer component, and a magnetic suction component, the sampling bracket is slidably connected to the second guide rail, the liquid transfer component is connected to the sampling bracket, and the liquid transfer component is provided with a gun head toward the reagent strip; the magnetic suction component is connected to the frame and is above the reagent strip, the sampling bracket is connected to one side of the magnetic suction component, and the other side of the magnetic suction component is provided with a detection module toward the bottom plate, and the detection module is provided with a lifting structure relative to the reagent strip. The present invention aims to achieve high integration of the body, improve space utilization, and avoid reagent contamination.

Description

Technical Field

[0001] The invention relates to the technical field of immunoassay analysis, and in particular to a fully automatic chemiluminescence analyzer. Background Art

[0002] Chemiluminescent immunoassay technology has become an important technology for modern clinical diagnosis due to its high sensitivity, high selectivity and wide application prospects. In recent years, fully automatic chemiluminescence analyzers have been widely used in clinical laboratories, hospitals and other medical institutions, especially in the early screening of diseases, detection of tumor markers, cardiovascular diseases, infectious diseases, etc. Fully automatic chemiluminescence analyzers have the advantages of high throughput, high degree of automation, and fast detection speed, which can significantly improve detection efficiency and accuracy.

[0003] Existing fully automatic chemiluminescence analyzers usually use test kits or reagent strips for testing, but these devices have some problems. First, the existing equipment has complex handling of reagent strips, which is prone to problems such as inaccurate reagent addition and difficulty in reagent replacement, increasing the workload of operators. Secondly, although the fully automatic chemiluminescence analyzer has achieved automated processing of samples and reagents to a certain extent, due to the lack of an effective TIP head management and recovery system, there is still a risk of cross contamination, which affects the accuracy of the test results. In addition, the equipment is large in size and has limited space for use, making it unsuitable for use in small medical institutions. Summary of the invention

[0004] The main purpose of the present invention is to provide a fully automatic chemiluminescence analyzer, aiming to achieve high integration of the machine body, improve space utilization, and avoid reagent contamination.

[0005] To achieve the above-mentioned object, the present invention proposes a fully automatic chemiluminescence analyzer, comprising a frame, the frame is provided with a bottom plate, the bottom plate is provided with a first guide rail penetrating the frame, a reaction module is slidably connected to the first guide rail, and a first driving member is provided at one end facing the reaction module, a reaction chamber is provided at the end face of the reaction module away from the bottom plate, a waste liquid box is provided at the bottom edge of the reaction module away from the first driving member, a mounting groove is provided in the reaction chamber, and a reagent strip is clamped;

[0006] The frame is provided with a second guide rail toward the bottom plate, and a sampling transfer module is slidably connected to the second guide rail. The sampling transfer module includes a sampling bracket, a pipetting component, and a magnetic suction component. The sampling bracket is slidably connected to the second guide rail and is connected to a second driving member. The pipetting component is connected to the sampling bracket, and the pipetting component is provided with a gun head toward the reagent strip;

[0007] The magnetic suction component is connected to the frame and is located above the reagent strip. The sampling bracket is connected to one side of the magnetic suction component. The other side of the magnetic suction component is provided with a detection module facing the bottom plate. The detection module is provided with a lifting structure relative to the reagent strip.

[0008] The reagent strip is provided with a TIP head mounting hole, a plurality of reaction grooves, and a light-proof test slot in sequence along the direction from the pipetting component to the detection module. A TIP head structure is provided in the TIP head mounting hole. The reaction module is provided with a detection component facing the TIP head structure. The TIP head structure is located above the waste liquid box, and the TIP head structure is connected to the gun head.

[0009] In one embodiment of the present application, the reaction module includes a support plate and a reaction base, the support plate is slidably connected to the first guide rail, the waste liquid box is connected to the support plate and is arranged toward the reagent strip, one end of the reaction base is connected to the support plate, and the other end is connected to the reaction chamber, and the reaction base is provided with a heating structure away from the reaction chamber;

[0010] There are multiple reaction chambers, and the multiple reaction chambers are arranged at intervals along a direction perpendicular to the first guide rail.

[0011] In one embodiment of the present application, the pipetting assembly includes a pipetting plate and a negative pressure assembly. The pipetting plate is connected to the end face of the sampling bracket facing away from the magnetic suction assembly. The negative pressure assembly is connected to the pipetting plate and has a gun head facing the reagent strip.

[0012] In one embodiment of the present application, the negative pressure assembly includes a third guide rail, a cylinder body, a piston rod, and a slider. The cylinder body is connected to the pipetting plate, the third guide rail is connected to the pipetting plate in a direction perpendicular to the cylinder body, the slider is slidably connected to the third guide rail, and is connected to a third driving member away from the cylinder body. The piston rod is penetrated through the cylinder body and is provided with a sealing plug relative to the cylinder body, and the slider is driven and connected to the piston rod.

[0013] In one embodiment of the present application, the magnetic attraction component includes a magnetic attraction plate and a permanent magnet, the magnetic attraction plate is parallel to the base plate and connected to the frame, the magnetic attraction plate is provided with a fourth guide rail relative to the permanent magnet, and the end of the permanent magnet facing away from the pipetting component is driven and connected to a fourth driving member.

[0014] In one embodiment of the present application, the permanent magnet is provided with a connection structure facing the pipetting component, and the connection structure is located between the reagent strip and the gun tip.

[0015] In one embodiment of the present application, the detection module includes a slider connecting block and a photon counter. The slider connecting block is connected to the side edge of the magnetic plate and is located above the reaction module. The photon counter is slidably connected to the slider connecting block, and the photon counter is connected to a lifting structure away from the bottom plate.

[0016] In one embodiment of the present application, a fifth guide rail perpendicular to the first guide rail is provided on the side of the magnetic plate away from the pipetting component, a detection bracket is slidably connected to the fifth guide rail, and a fifth driving member is provided relative to the detection bracket, and the detection bracket is drivingly connected to the slider connecting block.

[0017] In one embodiment of the present application, the outer periphery of the frame and the bottom plate is covered with a shell, and the end surface of the shell facing away from the first driving member is provided with an inlet and outlet relative to the reaction module, the inlet and outlet is rotatably connected to a warehouse door, the first guide rail is connected to the warehouse door, and the reaction module is passed through the inlet and outlet;

[0018] The housing is detachably connected with a controller module.

[0019] In one embodiment of the present application, the bin door is rotatably connected to the bottom edge of the inlet and outlet, and is provided with a torsion spring relative to the outer shell, and the reaction module is provided with a top block protruding toward the bin door.

[0020] By adopting the above technical solution, the present invention has the following advantages:

[0021] 1. The frame is arranged on the bottom plate, and the use of the two as a framework can facilitate the design of the installation position of other mechanisms. The first guide rail is used to enable the reaction module to move forward and backward with the help of the first driving member. A reagent strip is installed and fixed in the reaction chamber arranged on the reaction module, and the reagent strip is provided with a TIP head mounting hole with a TIP head structure installed, multiple reaction grooves, and a light-proof test groove in sequence along the direction from the pipetting component to the detection module, and the sampling bracket and the pipetting component are fixed on the frame by the second guide rail and can only move up and down. Through the first guide rail, different slots of the reagent strip can pass under the pipetting component in sequence, and the gun head arranged on the pipetting component punches holes in the sealing film arranged on the groove, so that the TIP head structure can be easily extended into the groove to take liquid and transfer liquid for testing. With the help of the first guide rail, the gun head punches holes for multiple reaction grooves in sequence along the direction from the detection module to the pipetting component, and when the TIP head structure reaches the bottom of the gun head, the gun head is connected by a snap-on method. The TIP head structure, further, the reaction module turns and moves, so that the TIP head structure can pass through multiple reaction grooves in sequence with the help of the gun head connected to the pipetting component, and perform multiple steps such as taking the liquid to be tested, diluting the liquid, and transferring the liquid in sequence. The magnetic suction component can be used to screen the liquid in the reaction process and discharge the useless and non-magnetic parts, thereby achieving the purpose of cleaning the reagent liquid. When the TIP head structure completes the task, the reaction module moves in the opposite direction again. When passing through the TIP head mounting hole, the TIP head structure can be separated from the gun head with the cooperation of the pipetting component, so that the TIP head can be sent from the reaction module to the bottom of the detection module together with the reagent strip for the final test, and can be recovered together after the test is completed. Through the above structure, the internal structure of the body can be highly integrated, the detection efficiency can be improved, and the space can be effectively saved, so that the size of the analyzer can be reduced, and the reduced analyzer can be suitable for more scenarios.

[0022] 2. A waste liquid box is provided at the end of the reaction module that is away from the first driving member and faces the TIP head mounting hole of the reagent strip. With the help of the waste liquid box, when the TIP head structure is reinserted into the TIP head mounting hole after the test is completed, but before the recovery process is carried out, the waste liquid that has not been emptied inside will be directly received by the waste liquid box, which can effectively avoid contamination. At the same time, it is also more convenient to recover the TIP head structure together with the reagent strip after the test, which can effectively improve the test efficiency.

[0023] 3. The sampling and transfer module includes a second guide rail, a sampling bracket, a pipetting assembly, and a magnetic suction assembly. The second guide rail is located between the frame and the magnetic suction assembly. The pipetting assembly can reciprocate in the opposite direction along the vertical line with the cooperation of the sampling bracket and the second guide rail. The structures of half of the first driving member, the second driving member, the third driving member and other driving members are similar, and can all be a structure of a screw rod and a motor. By using the screw rod logic in the sampling bracket, the moving distance of the object can be controlled more flexibly and with high precision, which can effectively avoid the TIP head structure from hitting the groove of the reagent strip and causing damage, and can effectively ensure safe use. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying creative work.

[0025] Figure 1 It is a structural schematic diagram of the fully automatic chemiluminescence analyzer of the present invention;

[0026] Figure 2 Another structural schematic diagram of the fully automatic chemiluminescence analyzer of the present invention;

[0027] Figure 3 is a cross-sectional view of the fully automatic chemiluminescence analyzer of the present invention;

[0028] Figure 4 It is a structural schematic diagram of a frame of the fully automatic chemiluminescence analyzer of the present invention from one perspective;

[0029] Figure 5 It is a structural schematic diagram of another viewing angle of the frame of the fully automatic chemiluminescence analyzer of the present invention;

[0030] Figure 6 It is a structural schematic diagram of the liquid transfer assembly of the fully automatic chemiluminescence analyzer of the present invention;

[0031] Figure 7 It is a cross-sectional view of the liquid transfer assembly of the fully automatic chemiluminescence analyzer of the present invention.

[0032] Description of Figure Numbers:

[0033] 1. Rack; 11. Bottom plate; 12. First guide rail; 13. Second guide rail; 2. Reaction module; 21. Support plate; 22. Waste liquid box; 23. Reaction base; 24. Reaction chamber; 3. Reagent strip; 4. Sampling transfer module; 41. Sampling bracket; 5. Pipetting assembly; 51. Pipetting plate; 52. Negative pressure assembly; 6. Magnetic assembly; 61. Magnetic plate; 62. Permanent magnet; 7. Detection module; 71. Fifth guide rail; 72. Detection bracket; 73. Slider connecting block; 74. Photon counter; 8. Housing; 81. Chamber door; 9. Controller module.

[0034] The realization of the purpose, functional features and advantages of the present invention will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0035] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0036] Reference Figures 1 to 7 To achieve the above-mentioned purpose, the present invention proposes a fully automatic chemiluminescence analyzer, comprising a frame 1, the frame 1 is provided with a bottom plate 11, the bottom plate 11 is provided with a first guide rail 12 penetrating the frame 1, a reaction module 2 is slidably connected to the first guide rail 12, and a first driving member is provided at one end facing the reaction module 2, a reaction chamber 24 is provided at the end face of the reaction module 2 away from the bottom plate 11, a waste liquid box 22 is provided at the bottom edge of the reaction module 2 away from the first driving member, a mounting groove is provided in the reaction chamber 24, and a reagent strip 3 is clamped;

[0037] The frame 1 is provided with a second guide rail 13 toward the bottom plate 11, and a sampling transfer module 4 is slidably connected to the second guide rail 13. The sampling transfer module 4 includes a sampling bracket 41, a pipetting component 5, and a magnetic suction component 6. The sampling bracket 41 is slidably connected to the second guide rail 13 and is connected to a second driving member. The pipetting component 5 is connected to the sampling bracket 41, and the pipetting component 5 is provided with a gun head toward the reagent strip 3;

[0038] The magnetic component 6 is connected to the frame 1 and is located above the reagent strip 3. The sampling bracket 41 is connected to one side of the magnetic component 6. The other side of the magnetic component 6 is provided with a detection module 7 facing the bottom plate 11. The detection module 7 is provided with a lifting structure relative to the reagent strip 3.

[0039] The reagent strip 3 is provided with a TIP head mounting hole, multiple reaction grooves, and a light-proof test groove in sequence along the direction from the pipetting component 5 to the detection module 7. A TIP head structure is provided in the TIP head mounting hole. The reaction module 2 is provided with a detection component facing the TIP head structure. The TIP head structure is located above the waste liquid box 22, and the TIP head structure is connected to the gun head.

[0040] The frame 1 is arranged on the bottom plate 11, and using the two as a framework can facilitate the design of the installation position of other mechanisms. The first guide rail 12 is used to enable the reaction module 2 to move forward and backward with the help of the first driving member. A reagent strip 3 is installed and fixed in the reaction chamber 24 provided on the reaction module 2, and the reagent strip 3 is provided with a TIP head mounting hole with a TIP head structure installed, multiple reaction grooves, and a light-proof test groove in sequence along the direction from the pipetting component 5 to the detection module 7, and the sampling bracket 41 and the pipetting component 5 are fixed on the frame 1 through the second guide rail 13 and can only move up and down. Through the first guide rail 12, different slots of the reagent strip 3 can be passed under the pipetting component 5 in sequence, and the gun head provided on the pipetting component 5 punches holes in the sealing film provided on the groove, so that the TIP head structure can be easily extended into the groove to take liquid and transfer liquid for testing. With the help of the first guide rail 12, the gun head punches holes for multiple reaction grooves in sequence along the direction from the detection module 7 to the pipetting component 5, and when the TIP head structure reaches the bottom of the gun head, the gun head The TIP head structure is connected by a snap-on method. Further, the reaction module 2 turns and moves, so that the TIP head structure can pass through multiple reaction grooves in sequence with the help of the gun head connected to the pipetting component 5, and perform multiple steps such as taking the liquid to be tested, diluting the liquid, and transferring the liquid in sequence. The magnetic suction component 6 can be used to screen the liquid in the reaction process and discharge the useless and non-magnetic parts, thereby achieving the purpose of cleaning the reagent liquid. When the TIP head structure completes the task, the reaction module 2 moves in the opposite direction again. When passing through the TIP head mounting hole, the TIP head structure can be separated from the gun head with the cooperation of the pipetting component 5, so that the TIP head can be sent from the reaction module 2 to the bottom of the detection module 7 together with the reagent strip 3 for the final test, and can be recovered together after the test is completed. Through the above structure, a high degree of integration of the internal structure of the body can be achieved, the detection efficiency can be improved, and space can be effectively saved, so that the size of the analyzer can be reduced, and the reduced analyzer can be suitable for more scenarios.

[0041] A waste liquid box 22 is provided at the end of the reaction module 2 that is away from the first driving member and faces the TIP head mounting hole of the reagent strip 3. With the help of the waste liquid box 22, when the TIP head structure is reinserted into the TIP head mounting hole after the test is completed, but the recovery process has not yet been carried out, the waste liquid that has not been emptied inside will be directly received by the waste liquid box 22, which can effectively avoid contamination. At the same time, it is also more convenient to recover the TIP head structure together with the reagent strip 3 after the test, which can effectively improve the test efficiency.

[0042] The sampling transfer module 4 includes a second guide rail 13, a sampling bracket 41, a pipetting component 5, and a magnetic suction component 6. The second guide rail 13 is located between the frame 1 and the magnetic suction component 6. The pipetting component 5 can reciprocate in the opposite direction along the vertical line with the cooperation of the sampling bracket 41 and the second guide rail 13. Generally, the structures of the first driving member, the second driving member, the third driving member and other driving members are similar, and can all be a structure of a screw rod and a motor. The screw rod is screwed to the sampling bracket 41, and the screw rod can be used to more flexibly and accurately control the moving distance of the object, which can effectively avoid the TIP head structure from hitting the groove of the reagent strip 3 and causing damage, and can effectively ensure safety in use.

[0043] Combined with reference Figure 4 The reaction module 2 includes a support plate 21 and a reaction base 23. The support plate 21 is slidably connected to the first guide rail 12. The waste liquid box 22 is connected to the support plate 21 and is arranged toward the reagent strip 3. One end of the reaction base 23 is connected to the support plate 21, and the other end is connected to the reaction chamber 24. The reaction base 23 is provided with a heating structure away from the reaction chamber 24; there are multiple reaction chambers 24, and the multiple reaction chambers 24 are arranged at intervals along a direction perpendicular to the first guide rail 12.

[0044] The support plate 21 can make the reaction base 23 away from the bottom plate 11, so that the heating structure installed at the bottom of the reaction bottom plate 11, such as a heating film, can be easily heated. At the same time, the support plate 21 can make the height of the reaction chamber 24 higher, so that when the TIP head structure is inserted into the TIP head installation hole, the TIP head structure can be suspended relative to the waste liquid box 22 to avoid damage to the TIP head structure. The extension direction of the reaction chamber 24 is set along the extension direction of the first guide rail 12, and the reagent strip 3 is inserted into the reaction chamber 24, and multiple reaction chambers 24 are spaced apart in a direction perpendicular to the first guide rail 12, so that the analyzer can test multiple reagent strips 3 at the same time to improve the test efficiency.

[0045] Combined with reference Figures 4 to 7 The pipetting assembly 5 includes a pipetting plate 51 and a negative pressure assembly 52 . The pipetting plate 51 is connected to the end surface of the sampling bracket 41 facing away from the magnetic suction assembly 6 . The negative pressure assembly 52 is connected to the pipetting plate 51 and is provided with a gun head facing the reagent strip 3 .

[0046] The pipetting plate 51 is connected to the sampling bracket 41, and together with the sampling bracket 41, is completely covered by the second guide rail 13. This structure can effectively ensure the stability of the moving track of the pipetting component 5, can effectively ensure that the gun tip stably clamps the TIP head structure, and ensure the moving trajectory of the TIP head structure. The negative pressure component 52 is used to generate negative pressure, and through the cooperation of the gun tip and the TIP head structure, the TIP head structure can be stably used to achieve the effect of aspirating and transferring liquid, and can effectively avoid the outflow of liquid due to the shaking of the TIP head structure, and can effectively prevent contamination.

[0047] Furthermore, in order to facilitate the automatic removal of the TIP head structure from the gun head, combined with Figure 6 and Figure 7 It can be seen that in a feasible embodiment, a push plate is also provided below the pipetting component 5, and guide pillars are provided on both sides of the push plate. The guide pillars pass through both sides of the cylinder body, and the guide pillars are fixedly connected to the push plate, and the guide pillars are slidably connected to the cylinder body. A spring is sleeved on the other end of the guide pillar, and a limit block is provided on the top of the guide pillar. The spring is provided between the limit block and the cylinder body. Through this structure, before the limit block is subjected to an additional force other than the gravity of the entire mechanism and the elastic force of the spring, the limit block can make the push plate always fit with the bottom surface of the cylinder body under the action of the spring force. The push plate is also provided with a through hole adapted to the gun head, and this through hole cooperates with the gap of the gun head, so that the gun head can pass freely through the through hole; in addition, when the TIP head structure is picked up, the end face of the TIP head structure fits with the bottom surface of the push plate to ensure that the TIP head structure is locked more firmly. When the test is completed, the TIP head structure needs to be returned to the TIP head mounting hole of the reagent strip 3; the slider moves downward under the drive of the third driving member, so that the piston rod moves downward, and a positive pressure is formed on the liquid in the TIP head, and the liquid is squeezed into the groove corresponding to the reagent strip 3. The piston rod continues to move downward, and the liquid in the TIP head will be squeezed out completely. When the slider exceeds the normal cyclic motion range and continues to push the piston rod downward under the drive of the screw rod, the two ends of the slider will apply a downward pressure to the limit block and the spring, and the push plate will move downward, so that the TIP head structure is pushed down from the gun head fully automatically. This pipette assembly can realize the actions of liquid suction, transfer, and cleaning of the reagent, and can also realize the picking and unloading of the TIP head structure, and can also realize the automatic puncture of the heat-sealed aluminum film of the reagent strip 3, thereby integrating the realization of multiple functions into one mechanism, greatly saving the space of the equipment, reducing costs, and improving production efficiency.

[0048] Combined with reference Figure 6 to Figure 7 The negative pressure assembly 52 includes a third guide rail, a cylinder body, a piston rod, and a slider. The cylinder body is connected to the pipetting plate 51. The third guide rail is connected to the pipetting plate 51 in a direction perpendicular to the cylinder body. The slider is slidably connected to the third guide rail and is connected to a third driving member away from the cylinder body. The piston rod is penetrated through the cylinder body and is provided with a sealing plug relative to the cylinder body. The slider is driven and connected to the piston rod.

[0049] The slider is assembled on the pipetting plate 51 by sliding in the vertical direction through the third guide rail structure. The output end of the third driving component is connected to the slider to drive the slider to slide in the vertical direction. The piston rod is connected to the cylinder body in a vertical sliding direction. The top of the piston rod is exposed from the cylinder body and connected to the slider. A sealing ring that fits tightly with the piston rod is provided in the cylinder body. The third driving component drives the slider to move upward to pull the piston rod, thereby forming a negative pressure cavity between the piston rod and the cylinder body, thereby achieving liquid suction. The suction accuracy and efficiency can be guaranteed by the screw rod.

[0050] Combined with reference Figures 3 to 5 The magnetic attraction component 6 includes a magnetic attraction plate 61 and a permanent magnet 62. The magnetic attraction plate 61 is parallel to the bottom plate 11 and connected to the frame 1. The magnetic attraction plate 61 is provided with a fourth guide rail relative to the permanent magnet 62. The end of the permanent magnet 62 facing away from the pipetting component 5 is driven and connected to a fourth driving member.

[0051] The magnetic attraction component 6 includes a permanent magnet 62 and a magnetic attraction plate 61. The permanent magnet 62 is parallel to the first guide rail 12 through the fourth guide rail structure and is slidably assembled on the magnetic attraction plate 61. The magnetic attraction plate 61 is fixedly connected to the frame 1, and the sampling bracket 41 is fixed on the front of the magnetic attraction plate 61. The permanent magnet 62 is fixed on the back of the magnetic attraction plate 61. A fourth driving member is also provided on the back of the magnetic attraction plate 61. The fourth driving member can drive the permanent magnet 62 to move along the fourth guide rail toward the pipetting component 5 and match with the TIP head, so that when the TIP head absorbs the reaction reagent, the magnetic beads in the reagent are adsorbed, and then the reaction reagent without magnetic beads is discharged through the piston rod and the cylinder structure to achieve a cleaning effect.

[0052] Combined with reference Figure 4 The permanent magnet 62 is provided with a connection structure toward the pipetting component 5, and the connection structure is located between the reagent strip 3 and the gun tip.

[0053] In the present application, a permanent magnet 62 is provided on the connection structure away from the pipetting component 5. By utilizing the connection structure, the permanent magnet 62 can cover a larger range of the TIP head structure, which can effectively improve the cleaning effect.

[0054] Combined with reference Figure 5 The detection module 7 includes a slider connecting block 73 and a photon counter 74. The slider connecting block 73 is connected to the side edge of the magnetic plate 61 and is located above the reaction module 2. The photon counter 74 is slidably connected to the slider connecting block 73. The photon counter 74 is connected to a lifting structure away from the bottom plate 11.

[0055] The slider connecting block 73 is provided with a guide rail for moving the photon counter 74 up and down and limiting the position, and is also connected to a lifting structure relative to the photon counter 74. With this structure, when the light-proof test slot on the reagent strip 3 is directly below it, the photon counter 74 will move down and be sealed and connected to the light-proof test slot, which can effectively improve the detection efficiency.

[0056] Combined with reference Figure 5 A fifth guide rail 71 perpendicular to the first guide rail 12 is provided on the side of the magnetic plate 61 away from the pipetting component 5, a detection bracket 72 is slidably connected to the fifth guide rail 71, and a fifth driving member is provided relative to the detection bracket 72, and the detection bracket 72 is drivingly connected to the slider connecting block 73.

[0057] Because there are multiple reaction chambers 24 and multiple reagent strips 3, in order to be able to test multiple reagent strips 3 in different positions, the detection module 7 also includes a detection bracket 72 and a fifth guide rail 71, and the slider connecting block 73 is fixed on the detection bracket 72. With the help of the fifth guide rail 71 and the upgraded structure, even if the photon counter 74 has only a single test probe, it can successfully detect multiple reagent strips 3.

[0058] Combined with reference Figures 1 to 3 The outer periphery of the frame 1 and the bottom plate 11 is covered with a shell 8, and the end surface of the shell 8 facing away from the first driving member is provided with an inlet and outlet relative to the reaction module 2, and the inlet and outlet are rotatably connected to a warehouse door 81, the first guide rail 12 is connected to the warehouse door 81, and the reaction module 2 is penetrated by the inlet and outlet; the shell 8 is detachably connected to the controller module 9.

[0059] The outer shell 8 can protect the internal components, and the inlet and outlet ports can facilitate the free entry and exit of the reaction module 2 and the loading and unloading of the reagent strips 3. The compartment door 81 of the inlet and outlet ports can be a door structure whose opening and closing is fully automatically controlled by the controller module 9. The controller module 9 itself can be disassembled, and one controller module 9 can control one or more chemiluminescence analyzers using network cables, WiFi, Bluetooth, etc., which can effectively improve the user experience.

[0060] Combined with reference Figure 3 The warehouse door 81 is rotatably connected to the bottom edge of the material inlet and outlet, and is provided with a torsion spring relative to the shell 8 . The reaction module 2 is provided with a top block protruding toward the warehouse door 81 .

[0061] In the present application, when the door 81 is installed and the machine body is in a natural state without working, the inlet and outlet can be firmly closed with the help of a torsion spring. The bottom edge of the reaction module 2 is provided with a top block. By using the top block, when the reaction module 2 moves toward the door 81, the door 81 can be fully automatically unfolded. At this time, the reagent strip 3 can be removed or installed from the reaction module 2. The reaction module 2 can slide inward along the first guide rail 12 under the drive of the motor until the door 81 is completely closed under the torsion of the torsion spring. The door 81 can be automatically closed and opened without manual operation, which can effectively improve the user experience.

[0062] The same or similar numbers in the drawings of this embodiment correspond to the same or similar parts; in the description of this application, it should be understood that if the terms "upper", "lower", "left", "right", etc. indicate an orientation or position relationship based on the orientation or position relationship shown in the drawings, it is only for the convenience of describing this application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, the terms describing the position relationship in the drawings are only used for illustrative purposes and cannot be understood as a limitation on this patent. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to specific circumstances.

[0063] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A fully automatic chemiluminescence analyzer, comprising a frame, characterized in that: The frame is provided with a bottom plate, the bottom plate is provided with a first guide rail penetrating the frame, a reaction module is slidably connected to the first guide rail, and a first driving member is provided at one end facing the reaction module, a reaction chamber is provided at an end face of the reaction module away from the bottom plate, a waste liquid box is provided at a bottom edge of the reaction module away from the first driving member, a mounting groove is provided in the reaction chamber, and a reagent strip is clamped; The frame is provided with a second guide rail toward the bottom plate, and a sampling transfer module is slidably connected to the second guide rail. The sampling transfer module includes a sampling bracket, a pipetting component, and a magnetic suction component. The sampling bracket is slidably connected to the second guide rail and is connected to a second driving member. The pipetting component is connected to the sampling bracket, and the pipetting component is provided with a gun head toward the reagent strip; The magnetic suction component is connected to the frame and is located above the reagent strip. The sampling bracket is connected to one side of the magnetic suction component. The other side of the magnetic suction component is provided with a detection module facing the bottom plate. The detection module is provided with a lifting structure relative to the reagent strip. The reagent strip is provided with a TIP head mounting hole, a plurality of reaction grooves, and a light-proof test slot in sequence along the direction from the pipetting component to the detection module. A TIP head structure is provided in the TIP head mounting hole. The reaction module is provided with a detection component facing the TIP head structure. The TIP head structure is located above the waste liquid box, and the TIP head structure is connected to the gun head.

2. A fully automatic chemiluminescence analyzer according to claim 1, characterized in that: The reaction module includes a support plate and a reaction base, wherein the support plate is slidably connected to the first guide rail, the waste liquid box is connected to the support plate and is arranged toward the reagent strip, one end of the reaction base is connected to the support plate, and the other end is connected to the reaction chamber, and the reaction base is provided with a heating structure away from the reaction chamber; There are multiple reaction chambers, and the multiple reaction chambers are arranged at intervals along a direction perpendicular to the first guide rail.

3. A fully automatic chemiluminescence analyzer according to claim 1, characterized in that: The pipetting assembly includes a pipetting plate and a negative pressure assembly. The pipetting plate is connected to the end surface of the sampling bracket away from the magnetic suction assembly. The negative pressure assembly is connected to the pipetting plate and is provided with a gun head facing the reagent strip.

4. A fully automatic chemiluminescence analyzer according to claim 3, characterized in that: The negative pressure assembly includes a third guide rail, a cylinder body, a piston rod, and a slider. The cylinder body is connected to the pipetting plate. The third guide rail is connected to the pipetting plate in a direction perpendicular to the cylinder body. The slider is slidably connected to the third guide rail and is connected to a third driving member away from the cylinder body. The piston rod passes through the cylinder body and is provided with a sealing plug relative to the cylinder body. The slider is drivingly connected to the piston rod.

5. A fully automatic chemiluminescence analyzer according to claim 1, characterized in that: The magnetic attraction component includes a magnetic attraction plate and a permanent magnet. The magnetic attraction plate is parallel to the bottom plate and connected to the frame. The magnetic attraction plate is provided with a fourth guide rail relative to the permanent magnet. The end of the permanent magnet facing away from the pipetting component is driven and connected to a fourth driving member.

6. A fully automatic chemiluminescence analyzer according to claim 5, characterized in that: The permanent magnet is provided with a connection structure facing the liquid transfer component, and the connection structure is located between the reagent strip and the gun head.

7. A fully automatic chemiluminescence analyzer according to claim 5, characterized in that: The detection module includes a slider connection block and a photon counter. The slider connection block is connected to the side edge of the magnetic plate and is located above the reaction module. The photon counter is slidably connected to the slider connection block. The photon counter is connected to a lifting structure away from the bottom plate.

8. A fully automatic chemiluminescence analyzer according to claim 7, characterized in that: A fifth guide rail perpendicular to the first guide rail is provided on one side of the magnetic plate away from the pipetting assembly. A detection bracket is slidably connected to the fifth guide rail, and a fifth driving member is provided relative to the detection bracket. The detection bracket is drivingly connected to the slider connecting block.

9. A fully automatic chemiluminescence analyzer according to claim 1, characterized in that: The outer periphery of the frame and the bottom plate is covered with a shell, and the end surface of the shell facing away from the first driving member is provided with an inlet and outlet relative to the reaction module, the inlet and outlet is rotatably connected to a warehouse door, the first guide rail is connected to the warehouse door, and the reaction module is passed through the inlet and outlet; The housing is detachably connected with a controller module.

10. A fully automatic chemiluminescence analyzer according to claim 9, characterized in that: The bin door is rotatably connected to the bottom edge of the material inlet and outlet, and is provided with a torsion spring relative to the outer shell. The reaction module is provided with a top block protruding toward the bin door.

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