Isolated heart perfusion device

Abstract

The isolated heart perfusion device comprises a rack, a portal frame is fixed to the top of the rack, a fixing plate is fixed to the bottom of a mounting frame through a support, a clamping mechanism is arranged on the fixing plate, the bottom of an intubation tube is sleeved with an air bag, and an air injection mechanism is arranged on the support. During use, after the intubation tube is inserted into the aortic tube, air can be supplied to the air injection cavity in the intubation tube through the air injection mechanism, and the air injection cavity transmits the air to the air bag located at the bottom of the intubation tube, so that the air bag is inflated to be expanded; therefore, the aortic tube area corresponding to the outer side position of the air bag can be expanded to form an independent bulge, and other positions can be kept to be original, so that the aortic tube can be prevented from slipping off from the intubation tube, the pre-fixation of the aortic tube is further realized, the success rate of intubation is improved, the operation time is shortened, repeated intubation is not needed, and the intubation efficiency is improved. The practicability is improved.

Description

Technical Field

[0001] The present invention relates to the technical field related to biomedical experimental instruments, and in particular to an isolated heart perfusion device. Background Art

[0002] In the field of biomedical research, isolated heart perfusion experiments are an important research method. Isolated heart perfusion refers to removing the animal's heart from the body and perfusing the heart with perfusion fluid through a perfusion device to maintain its normal activity state. During this process, the heart is separated from the body's neural and fluid regulation, allowing researchers to more directly observe and analyze the heart's physiological functions and responses.

[0003] In isolated heart perfusion experiments, fixation of the aorta is one of the key steps to ensure the smooth progress of the experiment. When using existing perfusion devices, it is necessary to insert a tube for delivering perfusion fluid into the aorta and fix the aorta. However, since the aortic wall is relatively soft and the inner wall has relatively lubricated tissue fluid, the existing perfusion device is not convenient for pre-fixing the aorta. Therefore, during intubation, the aorta is easy to slip off the tube, making it inconvenient to subsequently fix the aorta with a ligature. This requires repeated intubation of the aorta, which not only wastes time and affects heart activity, but also easily causes damage to the aorta and aortic valve, thereby affecting the accuracy of the experiment. Summary of the Invention

[0004] The object of the present invention is to provide an isolated heart perfusion device to solve the problem raised in the above-mentioned background art that, due to the relatively lubricating tissue fluid on the inner wall of the aorta, the existing perfusion device is inconvenient to pre-fix the aorta. Therefore, during intubation, the aorta is easily slipped off the tube, making it inconvenient to subsequently fix the aorta.

[0005] To achieve the above object, the present invention provides the following technical solution: an isolated heart perfusion device, comprising a frame, A gantry is fixed on the top of the frame, and a movable seat is provided below the top of the gantry. A cylinder is fixed on the bottom of the movable seat, and a mounting bracket is fixed on the output end of the cylinder. A fixing plate is fixed on the bottom of the mounting bracket through a bracket, and a cannula is fixed through the midpoint of the fixing plate. The fixing plate is provided with a clamping mechanism, the interior of the cannula is respectively provided with an infusion cavity and an air injection cavity, and the infusion cavity is connected to the delivery tube, the bottom of the cannula is provided with an air bag, and the air bag is connected to the air injection cavity, and the bracket is provided with an air injection mechanism; Heart tissue is provided below the mounting frame and is connected to the cannula via the aortic tube. A transverse movement mechanism is provided on the gantry frame and is used to drive the movable seat to move transversely. An infusion mechanism is provided on the top of the gantry, a heart monitor is provided on the inside of the gantry, and a control panel is provided on the outside of the gantry. An adjustment mechanism is provided on the inner wall of the gantry, and the adjustment mechanism is used to drive the heart monitor to move vertically. A collection box is provided on the top of the frame, and a cleaning chamber and a drying chamber are respectively provided at both ends of the interior of the frame.

[0006] In the above technical solution, when in use, the cannula is inserted into the aortic tube, and then the gas injection mechanism can be used to supply gas to the gas injection cavity inside the cannula, and the gas injection cavity will transmit the gas to the airbag at the bottom of the cannula, thereby inflating the airbag to make it expand. Since the aortic tube is an elastic artery, the aortic tube area corresponding to the outer side of the airbag will be stretched and expanded, thereby preventing the aortic tube from slipping, thereby achieving pre-fixation of the aortic tube.

[0007] After the aortic tube is fixed, the infusion mechanism can deliver perfusion fluid to the infusion cavity inside the cannula through the delivery tube, so that the perfusion fluid is delivered from the cannula to the aortic tube and the heart tissue for a perfusion experiment. During the experiment, the position of the heart monitor can be adjusted by the adjustment mechanism so that various positions of the heart tissue can be monitored. The adjustment mechanism can automatically adjust the position of the heart monitor.

[0008] Since the heart has many blood vessels and capillaries, during the perfusion process, the perfusate will seep out from other blood vessels. The function of the collection box is to collect the leaked perfusate to avoid contamination and waste of the perfusate.

[0009] Preferably, the clamping mechanism includes a rotating plate, which passes through the fixed plate and is rotatably connected thereto, and an arc-shaped clamping block is fixed to the bottom of the rotating plate, and a spring is fixed to the side of the rotating plate, and the spring is connected to the cannula.

[0010] In the above technical solution, by pressing the tops of the two sets of rotating plates to make the tops of the two sets of rotating plates close to each other, the arc-shaped clamping blocks at the bottom of the two sets of rotating plates can be moved away from each other, so that the aortic tube can be sleeved on the cannula. After the sleeve is completed, the tops of the two sets of rotating plates can be loosened. At this time, the tops of the two sets of rotating plates will move away from each other under the elastic force of the springs, and the arc-shaped clamping blocks at the bottom of the two sets of rotating plates will press the aortic tube on the cannula against each other, thereby achieving fixation of the aortic tube. This technical solution has a simple structure and is easy to operate, and can facilitate staff to quickly fix the aortic tube to avoid the aortic tube falling off during perfusion.

[0011] Preferably, the gas injection mechanism includes a gas injection pipe, which is fixed on the bracket, and a piston is provided inside the gas injection pipe, a push rod is vertically fixed on the piston, the gas injection pipe is connected to the gas injection cavity through a connecting pipe, and an exhaust valve is provided on the connecting pipe.

[0012] In the above technical solution, by pushing the push rod, the push rod will push the piston to slide inside the air injection tube. The piston will squeeze the air inside the air injection tube and push the air from the connecting tube to the air injection cavity inside the cannula to inflate the airbag. This technical solution is very convenient for inflating the airbag, and has a simple structure, low production and maintenance costs, and is conducive to later maintenance.

[0013] Preferably, vertical plates are provided at both ends of the bottom of the mounting frame, and arc-shaped limiting plates are provided on the sides of the vertical plates. A driving mechanism is provided at the bottom of the mounting frame, and the driving mechanism is used to drive the vertical plates to move horizontally.

[0014] In the above technical solution, the driving mechanism drives the two sets of vertical plates and the arc-shaped limiting plates closer to each other, so that the two sets of arc-shaped limiting plates can surround the heart tissue. This technical solution can prevent the heart tissue from shaking too much and affecting the stability of the aortic tube after fixation, and the two sets of arc-shaped limiting plates will not completely wrap the heart tissue, so that the heart monitor can monitor the heart tissue from between the two sets of arc-shaped limiting plates.

[0015] Preferably, the driving mechanism includes a motor 1, and the motor 1 is fixed to the side of the mounting frame. A screw rod 1 is installed at the bottom of the mounting frame, and the screw rod 1 is connected to the output end of the motor 1. The screw rod 1 passes through two sets of vertical plates and is threadedly connected to them, and the top of the vertical plate is slidably connected to the bottom of the mounting frame.

[0016] In the above technical solution, the motor drives the screw rod to rotate, so that the screw rod can drive the two sets of vertical plates threadedly connected to it to move closer to or away from each other.

[0017] Preferably, the transverse movement mechanism includes motor 2, which is fixed to the outer side of the gantry, and screw rod 2 is installed horizontally below the gantry, and screw rod 2 is connected to the output end of motor 2, and screw rod 2 passes through the movable seat and is threadedly connected to it, and the movable seat is slidably connected to the top of the gantry.

[0018] In the above technical solution, during continuous operation, in order to avoid cross-infection of different animal tissue fragments affecting the final accuracy of the experiment, the second motor can be used to drive the second screw to rotate, so that the second screw can drive the movable seat threadedly connected to it to move horizontally, and cooperate with the cylinder to drive the mounting frame to move vertically, so that the cannula under the mounting frame can be conveniently sent into the cleaning chamber and the drying chamber in turn for cleaning and drying.

[0019] Preferably, the infusion mechanism includes a liquid storage tank, which is fixed to the top of the gantry, and a peristaltic pump is fixed on the liquid storage tank, and the peristaltic pump is connected to the delivery tube.

[0020] In the above technical solution, the perfusion liquid can be injected through the liquid storage tank, and the peristaltic pump can transport the perfusion liquid to the cannula through the delivery tube, and then discharge it into the aorta and heart tissue for experiments.

[0021] Preferably, the adjustment mechanism includes a motor four, which is fixed to the inner wall of the gantry, and a screw rod three is vertically installed on the inner wall of the gantry, the screw rod three is connected to the output end of the motor four, and a slider is threaded on the screw rod three, one end of the slider is slidably connected to the inner wall of the gantry, and the other end of the slider is connected to the heart monitor.

[0022] In the above technical solution, the motor 4 drives the screw rod 3 to rotate, so that the screw rod 3 can drive the slider connected to it with a thread to move vertically, so that the slider drives the heart monitor to adjust the vertical position to monitor various positions of the heart tissue.

[0023] Compared with the prior art, the beneficial effects of the present invention are: the isolated heart perfusion device, (1) When in use, after the cannula is inserted into the aortic tube, the cannula can be supplied with gas through the gas injection mechanism to the gas injection cavity inside the cannula, and the gas injection cavity will transmit the gas to the air bag at the bottom of the cannula, thereby inflating the air bag and expanding it. Since the aortic tube is an elastic artery, the aortic tube area corresponding to the outer position of the air bag will be stretched and expanded to form an independent bulge, while the other positions will remain as they are. In this way, the aortic tube can be prevented from slipping off the cannula, thereby achieving pre-fixation of the aortic tube, thereby improving the success rate of cannulation, shortening the operation time, eliminating the need for repeated cannulation, and improving its practicality; (2) During the experiment, the heart monitor can be used to monitor the physiological functions and reactions of the isolated heart tissue. During the monitoring process, the position of the heart monitor can be adjusted by the adjustment mechanism so that various positions of the heart tissue can be monitored. The adjustment mechanism can automatically adjust the position of the heart monitor, thereby avoiding deviations in the monitoring position caused by manual adjustment, and helping to improve the accuracy of the experiment. (3) Since multiple animal hearts need to be monitored in order to improve the accuracy of the experiment in the isolated heart perfusion experiment, continuous operation is required. In order to avoid cross-infection of different animal tissue fragments affecting the final accuracy of the experiment during the continuous operation, the movable seat can be driven to move horizontally by the transverse movement mechanism, and the mounting frame can be driven vertically by the cylinder to move the cannula under the mounting frame in turn into the cleaning chamber and the drying chamber for cleaning and drying. This technical solution can facilitate the cleaning and drying of the cannula and its two side parts after the perfusion operation is completed. In the continuous operation, the time required for cleaning the cannula can be greatly shortened, which helps to improve the efficiency of the continuous operation. (4) Since the heart tissue will shake due to its beating when the perfusion fluid is delivered, during the monitoring of the heart tissue, the driving mechanism can drive the two sets of vertical plates and arc-shaped limit plates to move closer to each other, so that the two sets of arc-shaped limit plates can surround the heart tissue. This technical solution can prevent the heart tissue from shaking too much and help improve the stability of the aortic tube after fixation. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a schematic diagram of the front view structure of the present invention; Figure 2 This is a schematic side view of the mounting frame of the present invention; Figure 3 This is a side view of the fixed plate and the rotating plate of the present invention; Figure 4 Schematic diagram of the side cross-sectional structure of the cannula and the gas injection tube of the present invention; Figure 5 This is a schematic cross-sectional structural diagram of the liquid storage tank of the present invention; Figure 6 This is a schematic diagram of the frame structure from above according to the present invention.

[0025] In the figure: 1, frame, 2, gantry, 3, movable seat, 4, cylinder, 5, mounting frame, 6, bracket, 7, fixing plate, 8, cannula, 9, clamping mechanism, 901, rotating plate, 902, arc clamping block, 903, spring, 10, infusion cavity, 11, delivery tube, 12, injection cavity, 13, air bag, 14, injection mechanism, 1401, injection tube, 1402, piston, 1403, push rod, 1404, connecting tube, 1405, exhaust valve, 15, heart tissue, 16, aortic tube, 17, riser, 18, collar, 19, bolt, 20, arc limit plate, 21, driving mechanism, 2101, motor 1, 2102, screw rod 1, 22, Transverse movement mechanism, 2201, motor two, 2202, screw two, 23, infusion mechanism, 2301, liquid storage tank, 2302, peristaltic pump, 24, stirring mechanism, 2401, motor three, 2402, rotating rod, 2403, stirring rod, 25, heart monitor, 26, adjustment mechanism, 2601, motor four, 2602, screw three, 2603, slider, 27, collection box, 28, cleaning chamber, 29, drying chamber, 30, cleaning mechanism, 3001, motor five, 3002, cleaning cylinder, 3003, cleaning brush one, 3004, cleaning brush two, 3005, spray pipe, 31, drying mechanism, 3101, blowing fan, 3102, heating coil. DETAILED DESCRIPTION

[0026] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0027] See also Figure 1-6 The present invention provides a technical solution: an isolated heart perfusion device, such as Figure 1 、 Figure 2 、 Figure 3 、 Figure 4 、 Figure 5 and Figure 6 As shown, a gantry 2 is fixed to the top of the frame 1, and a movable seat 3 is provided below the top of the gantry 2. A cylinder 4 is fixed to the bottom of the movable seat 3, and a mounting frame 5 is fixed to the output end of the cylinder 4. A fixing plate 7 is fixed to the bottom of the mounting frame 5 through a bracket 6, and a cannula 8 is fixed through the midpoint of the fixing plate 7. A clamping mechanism 9 is provided on the fixing plate 7. An infusion cavity 10 and an air injection cavity 12 are respectively provided inside the cannula 8. The infusion cavity 10 is connected to the delivery tube 11. An air bag 13 is provided at the bottom of the cannula 8, and the air bag 13 is connected to the air injection cavity 12. An air injection mechanism 14 is provided on the bracket 6. A heart tissue 15 is provided below the mounting frame 5 and is connected to the cannula 8 via the aortic tube 16. A transverse movement mechanism 22 is provided on the gantry 2 for driving the movable seat 3 to move transversely. An infusion mechanism 23 is provided on the top of the gantry 2, a heart monitor 25 is provided on the inside of the gantry 2, and a control panel is provided on the outside of the gantry 2. An adjustment mechanism 26 is provided on the inner wall of the gantry 2, and the adjustment mechanism 26 is used to drive the heart monitor 25 to move vertically. A collection box 27 is provided on the top of the frame 1, and a cleaning chamber 28 and a drying chamber 29 are respectively provided at both ends of the interior of the frame 1.

[0028] Furthermore, a cleaning mechanism 30 and a drying mechanism 31 are respectively provided inside the cleaning chamber 28 and the drying chamber 29; The cleaning mechanism 30 includes a motor 5 3001, which is fixed to the bottom of the frame 1, and the output end of the motor 5 3001 is connected to the cleaning cylinder 3002. The cleaning cylinder 3002 is vertically installed in the cleaning chamber 28, and the inner and outer walls of the cleaning cylinder 3002 are respectively provided with a cleaning brush 1 3003 and a cleaning brush 2 3004, and spray pipes 3005 are provided at both ends of the inner wall of the cleaning chamber 28.

[0029] After the experiment is over, the cannula 8 is moved into the cleaning chamber 28 and inserted into the cleaning cylinder 3002. The motor 5 3001 can then be turned on to drive the cleaning cylinder 3002 to rotate. The cleaning brush 1 3003 on the inner wall of the cleaning cylinder 3002 and the cleaning brush 2 3004 on the outer wall of the cleaning cylinder 3002 can respectively brush the cannula 8 and the parts on both sides of the mounting frame 5. The spray pipe 3005 sprays the cleaning liquid to clean the tissue fragments on the cannula 8, so that manual cleaning is not required during continuous operation, thereby shortening the time required for cleaning the cannula 8 and improving its functionality.

[0030] The drying mechanism 31 includes a blowing fan 3101 , which is installed on the inner wall of the drying chamber 29 , and a heating coil 3102 is also provided inside the drying chamber 29 .

[0031] After cleaning the cannula 8, the cannula 8 is moved into the cleaning chamber 28. Heat can be generated by the heating ring 3102, and air can be blown by the blowing fan 3101. Several groups of blowing fans 3101 can evenly dry the cannula 8 and its two side parts with hot air to remove residual moisture for subsequent secondary operations.

[0032] like Figure 1 、 Figure 2 and Figure 3 As shown, the clamping mechanism 9 includes a rotating plate 901, which passes through the fixed plate 7 and is rotatably connected thereto, and an arc-shaped clamping block 902 is fixed to the bottom of the rotating plate 901, and a spring 903 is fixed to the side of the rotating plate 901, and the spring 903 is connected to the cannula 8.

[0033] like Figure 1 、 Figure 2 and Figure 3 As shown, the gas injection mechanism 14 includes a gas injection pipe 1401, which is fixed on the bracket 6, and a piston 1402 is provided inside the gas injection pipe 1401, and a push rod 1403 is vertically fixed on the piston 1402. The gas injection pipe 1401 is connected to the gas injection cavity 12 through a connecting pipe 1404, and an exhaust valve 1405 is provided on the connecting pipe 1404.

[0034] like Figure 1 and Figure 2 As shown, vertical plates 17 are provided at both ends of the bottom of the mounting frame 5, and arc-shaped limiting plates 20 are provided on the sides of the vertical plates 17. A driving mechanism 21 is provided at the bottom of the mounting frame 5, and the driving mechanism 21 is used to drive the vertical plates 17 to move horizontally.

[0035] Furthermore, a collar 18 is sleeved on the outer side of the vertical plate 17 , a bolt 19 is provided on the collar 18 , and the collar 18 is fixedly connected to the arc-shaped limiting plate 20 .

[0036] When in use, the ring 18 can be pushed to drive the arc-shaped limiting plate 20 to move vertically, so that the vertical position of the arc-shaped limiting plate 20 can be adjusted according to the size of different heart tissues 15 and the length of the aorta 16, making it more widely used and improving its practicality.

[0037] like Figure 1 and Figure 2 As shown, the driving mechanism 21 includes a motor 2101, and the motor 2101 is fixed to the side of the mounting frame 5. A screw rod 2102 is installed at the bottom of the mounting frame 5, and the screw rod 2102 is connected to the output end of the motor 2101. The screw rod 2102 passes through the two groups of vertical plates 17 and is threadedly connected thereto, and the top of the vertical plate 17 is slidably connected to the bottom of the mounting frame 5.

[0038] like Figure 1 As shown, the transverse movement mechanism 22 includes a second motor 2201, which is fixed to the outer side of the gantry 2, and a second screw rod 2202 is installed horizontally below the gantry 2, and the second screw rod 2202 is connected to the output end of the second motor 2201, and the second screw rod 2202 passes through the movable seat 3 and is threadedly connected to it, and the movable seat 3 is slidably connected to the top of the gantry 2.

[0039] like Figure 1 As shown, the infusion mechanism 23 includes a liquid storage tank 2301 , which is fixed to the top of the gantry 2 , and a peristaltic pump 2302 is fixed on the liquid storage tank 2301 , which is connected to the delivery tube 11 .

[0040] Furthermore, a stirring mechanism 24 is provided on the liquid storage tank 2301, and the stirring mechanism 24 includes a motor three 2401, which is fixed to the top of the liquid storage tank 2301, and the output end of the motor three 2401 is connected to the rotating rod 2402, which is installed inside the liquid storage tank 2301, and a plurality of stirring rods 2403 are fixed on the rotating rod 2402.

[0041] Since the perfusate is usually composed of multiple substances such as sodium, potassium, and calcium, the motor 2401 drives the rotating rod 2402 to rotate, which can drive the stirring rod 2403 to stir the perfusate inside the liquid storage tank 2301. This can ensure that the multiple substances are fully mixed and prevent the formation of sediment in the perfusate that affects the monitoring accuracy of the heart tissue 15.

[0042] like Figure 1As shown, the adjustment mechanism 26 includes a motor 4 2601, which is fixed to the inner wall of the gantry 2, and a screw rod 3 2602 is vertically installed on the inner wall of the gantry 2, the screw rod 3 2602 is connected to the output end of the motor 4 2601, and a slider 2603 is threadedly connected to the screw rod 3 2602, one end of the slider 2603 is slidably connected to the inner wall of the gantry 2, and the other end of the slider 2603 is connected to the heart monitor 25.

[0043] Working principle: When in use, after dissecting the heart tissue 15 and the aortic tube 16, press the tops of the two sets of rotating plates 901 to make the tops of the two sets of rotating plates 901 close to each other, so that the arc-shaped clamping blocks 902 at the bottom of the two sets of rotating plates 901 can be moved away from each other, and then the aortic tube 16 is placed on the cannula 8, and then the push rod 1403 is pressed. The push rod 1403 will push the piston 1402 to slide inside the gas injection tube 1401, and the piston 1402 will squeeze the air inside the gas injection tube 1401 and push the air from the connecting tube 1404 to the gas injection cavity 12 inside the cannula 8, and at the same time inflate the airbag 13. At this time, the active The vascular area 8 will be stretched and expanded to form an independent bulge to prevent the aortic tube 8 from slipping off the cannula 8. Then, the tops of the two sets of rotating plates 901 will be loosened. At this time, the tops of the two sets of rotating plates 901 will move away from each other under the elastic force of the spring 903, and the arc-shaped clamping blocks 902 at the bottom of the two sets of rotating plates 901 will press the aortic tube 16 on the cannula 8 against each other, thus completing the fixation of the aortic tube 16. Then, the motor 12101 is turned on to drive the screw rod 12102 to rotate, so that the screw rod 12102 drives the two sets of vertical plates 17 and the arc-shaped limiting plates 20 to move closer to each other. The two sets of arc-shaped limiting plates 20 will surround the heart tissue 15, but The heart tissue 15 is not completely wrapped. The heart monitor 25 can monitor the physiological functions and reactions of the heart tissue 15 between the two sets of arc-shaped limit plates 20. After that, the perfusion fluid in the liquid storage tank 2301 can be transported to the cannula 8 through the delivery tube 11 by the peristaltic pump 2302, so as to be discharged into the aorta 16 and the heart tissue 15 for experiments. During the perfusion process, the motor 4 2601 can be turned on to drive the screw rod 3 2602 to rotate, so that the screw rod 3 2602 drives the slider 2603 to move vertically, so that the slider 2603 drives the heart monitor 25 to adjust the vertical position to perform experiments at various positions of the heart tissue 15. Monitoring is performed. Since there are multiple blood vessels and capillaries on the heart, during the perfusion process, the perfusion fluid will seep out from other blood vessels. The collection box 27 collects the perfusion fluid that has seeped out to avoid contamination and waste of the perfusion fluid. After the experiment is completed and the heart tissue 15 and the aortic tube 16 are disassembled, the motor 2201 can be turned on to drive the screw 2202 to rotate, so that the screw 2202 drives the movable seat 3 to move horizontally, and cooperates with the cylinder 4 to drive the mounting frame 5 to move vertically, so that the cannula 8 under the mounting frame 5 can be conveniently sent into the cleaning chamber 28 and the drying chamber 29 in turn for cleaning and drying, so as to carry out secondary and continuous operations laterally.

[0044] This completes the entire operation, and the contents not described in detail in this specification belong to the prior art known to professional and technical personnel in this field.

[0045] The terms "center", "longitudinal", "transverse", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings. They are merely simplified descriptions for the convenience of describing the present invention, and do not indicate or imply that the devices or components referred to must have a specific direction, be constructed and operated in a specific direction. Therefore, they cannot be understood as limiting the protection content of the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. An isolated heart perfusion device, comprising a frame (1), characterized in that: A gantry (2) is fixed on the top of the frame (1), and a movable seat (3) is arranged below the top of the gantry (2); a cylinder (4) is fixed on the bottom of the movable seat (3), and a mounting frame (5) is fixed on the output end of the cylinder (4); a fixing plate (7) is fixed on the bottom of the mounting frame (5) via a bracket (6), and a plug (8) is fixed through the midpoint of the fixing plate (7); The fixing plate (7) is provided with a clamping mechanism (9); the interior of the cannula (8) is provided with an infusion cavity (10) and an air injection cavity (12), and the infusion cavity (10) is connected to the delivery tube (11); the bottom of the cannula (8) is provided with an air bag (13), and the air bag (13) is connected to the air injection cavity (12); and the bracket (6) is provided with an air injection mechanism (14); A heart tissue (15) is arranged below the mounting frame (5), and the heart tissue (15) is connected to the cannula (8) via an aortic tube (16); a transverse movement mechanism (22) is arranged on the gantry (2), and the transverse movement mechanism (22) is used to drive the movable seat (3) to move transversely; An infusion mechanism (23) is arranged on the top of the gantry (2), a heart monitor (25) is arranged on the inner side of the gantry (2), and a control panel is arranged on the outer side of the gantry (2). An adjustment mechanism (26) is arranged on the inner wall of the gantry (2), and the adjustment mechanism (26) is used to drive the heart monitor (25) to move vertically. A collection box (27) is arranged on the top of the frame (1), and a cleaning chamber (28) and a drying chamber (29) are respectively provided at two ends of the frame (1).

2. An isolated heart perfusion device according to claim 1, characterized in that: The clamping mechanism (9) comprises a rotating plate (901), the rotating plate (901) passes through the fixed plate (7) and is rotatably connected thereto, an arc-shaped clamping block (902) is fixed to the bottom of the rotating plate (901), a spring (903) is fixed to the side of the rotating plate (901), and the spring (903) is connected to the insertion tube (8).

3. An isolated heart perfusion device according to claim 1, characterized in that: The gas injection mechanism (14) comprises a gas injection pipe (1401), the gas injection pipe (1401) is fixed on the bracket (6), and a piston (1402) is arranged inside the gas injection pipe (1401), a push rod (1403) is vertically fixed on the piston (1402), the gas injection pipe (1401) is connected to the gas injection cavity (12) through a connecting pipe (1404), and an exhaust valve (1405) is arranged on the connecting pipe (1404).

4. An isolated heart perfusion device according to claim 1, characterized in that: Vertical plates (17) are arranged at both ends of the bottom of the mounting frame (5), and arc-shaped limit plates (20) are arranged on the sides of the vertical plates (17). A driving mechanism (21) is arranged at the bottom of the mounting frame (5), and the driving mechanism (21) is used to drive the vertical plates (17) to move horizontally.

5. An isolated heart perfusion device according to claim 4, characterized in that: The driving mechanism (21) comprises a motor 1 (2101), and the motor 1 (2101) is fixed to the side of the mounting frame (5), a screw rod 1 (2102) is installed at the bottom of the mounting frame (5), and the screw rod 1 (2102) is connected to the output end of the motor 1 (2101), the screw rod 1 (2102) passes through two groups of vertical plates (17) and is threadedly connected thereto, and the top of the vertical plate (17) is slidably connected to the bottom of the mounting frame (5).

6. An isolated heart perfusion device according to claim 1, characterized in that: The transverse movement mechanism (22) comprises a second motor (2201), the second motor (2201) being fixed to the outer side of the gantry (2), and a second screw rod (2202) being installed transversely below the gantry (2), the second screw rod (2202) being connected to the output end of the second motor (2201), and the second screw rod (2202) passing through the movable seat (3) and being threadedly connected thereto, and the movable seat (3) being slidably connected to the top of the gantry (2).

7. An isolated heart perfusion device according to claim 1, characterized in that: The infusion mechanism (23) comprises a liquid storage tank (2301), the liquid storage tank (2301) is fixed to the top of the gantry (2), and a peristaltic pump (2302) is fixed to the liquid storage tank (2301), and the peristaltic pump (2302) is connected to the delivery tube (11).

8. An isolated heart perfusion device according to claim 1, characterized in that: The adjustment mechanism (26) comprises a motor four (2601), the motor four (2601) being fixed to the inner wall of the gantry (2), and a screw rod three (2602) being vertically mounted on the inner wall of the gantry (2), the screw rod three (2602) being connected to the output end of the motor four (2601), and a slider (2603) being threadedly connected to the screw rod three (2602), one end of the slider (2603) being slidably connected to the inner wall of the gantry (2), and the other end of the slider (2603) being connected to the heart monitor (25).

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