Ablation system

Abstract

The application provides an ablation system. The ablation system of the application sets the ablation device and the imaging device in the same optical path, guides the ablation device to move to the lesion position of the region of interest through the imaging device in real time, monitors the ablation of the lesion position through the imaging device when the ablation device is used to ablate the lesion, and makes the ablation system highly integrated and convenient to use. Meanwhile, the accuracy of the imaging device is ensured by controlling the calibration of the ablation system through the calibration device before ablation starts. Further, the image of the working area is obtained in real time through the imaging device by controlling the cooperation between the imaging device and the ablation device, which facilitates the ablation of the ablation device. Meanwhile, the ablation effect is evaluated through the imaging device after ablation, which ensures the safety and completeness of the ablation.

Description

TECHNICAL FIELD

[0001] The present application relates to an ablation system, belonging to the field of interventional medical devices. BACKGROUND

[0002] Atherosclerosis is a serious and common vascular disease, mainly occurring in coronary arteries and lower limb arteries. Its clinical manifestations are the deposition of atherosclerotic plaques on the vascular wall, which are usually composed of lipid deposition, inflammatory cells, calcified substances and thrombus, etc. With the passage of time, the plaques may gradually increase and cause the arteries to become hard and narrow, and even occluded, thereby causing ischemic lesions in the corresponding organs.

[0003] At present, percutaneous vascular intervention technology has become the most widely used treatment for atherosclerotic lesions due to its minimally invasive nature, short operation time and rapid postoperative recovery. Intravascular laser ablation technology is one of the plaque volume reduction techniques. When implementing this technology, the ablation catheter is generally delivered to the lesion site, and then the head end emits laser to the lesion to ablate it, thereby restoring blood flow in the stenosis.

[0004] When performing percutaneous vascular intervention, it is generally performed under the guidance of angiography, which can provide the overall morphology of the blood vessels, but cannot indicate the nature of the plaque and its boundary with the vessel wall. In addition, angiography is easily affected by anatomical structure overlap and blood vessel tortuosity, resulting in poor assessment of some lesions.

[0005] In recent years, with the advent of intraluminal imaging, it has become possible to accurately provide the location and nature of the plaque during the operation. Among them, OCT uses near-infrared light to generate high-resolution images, which can well identify the morphological structure characteristics of the plaque, and has important guiding significance for the selection and evaluation of interventional treatment programs.

[0006] However, the current clinical laser ablation technology can only rely on traditional angiography for real-time guidance, and there is no real-time intraluminal imaging for blood vessel boundary and volume reduction volume judgment, which is the main reason for the occurrence of complications such as perforation and dissection. Even if there is no adverse event, the damage to the blood vessel wall caused by improper volume reduction will trigger a retaliatory vascular restenosis, affecting the long-term efficacy.

[0007] Therefore, it is necessary to provide a method for using an ablation system and an ablation system using the method for using the ablation system to solve the above problems. SUMMARY

[0008] The present application aims to provide an ablation system which guides ablation by using an imaging device with high resolution, and shares the light path of the imaging device with the ablation device, ensures the imaging field of view of the imaging device and the ablation field of view of the ablation device are the same, and then can accurately provide information such as lesion properties and position of the region of interest.

[0009] To achieve the above-mentioned purpose of the present application, the present application provides an ablation system, comprising:

[0010] An ablation device, comprising an ablation catheter, an ablation light source and a light beam transmission light path; the ablation light source provides an ablation light beam and transmits it to the ablation catheter through the light beam transmission light path to complete lesion ablation;

[0011] The ablation catheter comprises a front-end rigid part and a rear-end flexible part, the front-end rigid part at least comprises a shell, an actuator and a fiber cantilever; the rear-end flexible part comprises a fiber, a conductive cable and a sheath tube;

[0012] The fiber cantilever is a part of the fiber, the fiber extends through the actuator to form the fiber cantilever on one side of the actuator; one end of the fiber cantilever is fixed on the actuator, and the other end extends away from the actuator;

[0013] An imaging device, comprising an OCT imaging light source and an interferometer assembly, for providing an imaging light beam;

[0014] A coupling device for combining the imaging light beam of the imaging device and the ablation light beam of the ablation device, and coupling into the fiber in the ablation catheter;

[0015] A driving device for generating a voltage signal and acting on the actuator in the ablation catheter through the conductive cable, and driving the actuator to generate displacement;

[0016] A control device for controlling the operation of the imaging device and the ablation device to acquire an image of the region of interest by the imaging device, and complete the lesion ablation of the lesion position by the ablation device; the ablation system further comprises a calibration device; the calibration device is used to collect the front-end light beam scanning trajectory coordinates of the ablation catheter, for calibrating image distortion; the calibration device comprises a position sensor, which can collect the scanning trajectory coordinates of the light beam emitted by the front end of the ablation catheter in one motion cycle, and realize the calibration of the ablation device through image calibration.

[0017] As a further improvement of the present application, the control device is used to control the operation of the imaging device, the imaging device acquires real-time images of the region of interest through the fiber, and guides the ablation catheter to move to the region of interest.

[0018] The control device can locate and identify the lesion position of the region of interest based on the real-time image, and adjust the working position of the ablation catheter so that the working position overlaps with the lesion position.

[0019] The control device controls the ablation device to perform ablation work, so that the ablation light beam and / or the imaging light beam act on the lesion position through the optical fiber, and ablate and / or image the lesion at the lesion position.

[0020] As a further improvement of the present application, the image feature analysis of the control device on the real-time image includes judging whether the ablation device deviates from the lesion position during movement, guiding and adjusting the ablation catheter to move to the lesion position, and analyzing the lesion type at the lesion position based on the real-time image.

[0021] As a further improvement of the present application, the calibration of the ablation device by the calibration device includes controlling the actuator in the ablation catheter to drive the optical fiber cantilever in the ablation catheter to perform scanning motion at a preset voltage, and moving the ablation catheter to face the calibration device, thereby completing the calibration of the ablation device.

[0022] As a further improvement of the present application, the control device controls the ablation device to perform ablation work, including:

[0023] Adjusting the ablation light beam energy emitted by the ablation device according to the lesion type at the lesion position; and identifying the regional property of the region of interest where the ablation catheter is located according to the real-time image, and adjusting the operating state of the imaging device based on the regional property.

[0024] As a further improvement of the present application, when the regional property is a complex property, the control device controls the imaging device to operate in real time, the imaging device acquires the real-time image of the region of interest through the ablation catheter in real time, and adjusts the orientation of the ablation catheter based on the real-time image.

[0025] When the regional property is a simple property, the control device controls the imaging device to acquire the real-time image of the region of interest after ablation for a preset time or after ablation is completed, and evaluates the ablation effect.

[0026] As a further improvement of the present application, the imaging device includes an OCT imaging light source and an interferometer assembly.

[0027] To achieve the above object, the present application provides a method for using an ablation system, which comprises an ablation device, an imaging device, and a coupling device for coupling an imaging beam of the imaging device into an optical fiber of an ablation catheter of the ablation device; the method for using the ablation system comprises the following steps:

[0028] S1, controlling the imaging device to operate, the imaging device acquiring a real-time image of the region of interest through the optical fiber, guiding the ablation catheter to move to the region of interest;

[0029] S2, positioning and identifying a lesion position of the region of interest according to the real-time image, adjusting a working position of the ablation catheter, so that the working position overlaps with the lesion position;

[0030] S3, controlling the ablation device to perform ablation work, so that the ablation beam and / or the imaging beam act on the lesion position through the optical fiber, and ablation and / or imaging of the lesion at the lesion position are performed.

[0031] As a further improvement of the present application, the ablation device comprises an ablation light source, a beam transmission optical path, and an ablation catheter, the ablation catheter comprising a front-end rigid part and a rear-end flexible part, the front-end rigid part comprising at least a housing, an actuator, and an optical fiber cantilever; the rear-end flexible part comprising an optical fiber, a conductive cable, and a sheath.

[0032] As a further improvement of the present application, the optical fiber cantilever is a part of the optical fiber, the optical fiber extending through the actuator to form the optical fiber cantilever on one side of the actuator; so that one end of the optical fiber cantilever is fixed on the actuator, and the other end extends away from the actuator.

[0033] As a further improvement of the present application, before the S1, the method for using the ablation system further comprises S0, the S0 being: under a preset voltage, controlling the actuator in the ablation catheter to drive the optical fiber cantilever in the ablation catheter to perform a scanning motion, moving the ablation catheter so that it faces a calibration device, and completing calibration of the ablation device.

[0034] As a further improvement of the present application, the calibration device comprises a position sensor, the position sensor being capable of acquiring scanning trajectory coordinates of a light beam emitted by the front end of the ablation catheter in one motion cycle, and realizing calibration of the ablation device through image calibration.

[0035] As a further improvement of the present application, the S2 further comprises: performing image feature analysis on the real-time image, judging whether the ablation device deviates from the lesion position during movement, guiding and adjusting the ablation catheter to move to the lesion position, and analyzing the lesion type at the lesion position based on the real-time image.

[0036] As a further improvement of the present application, in the S3, the control of the ablation device to perform ablation work comprises:

[0037] adjusting the ablation light beam energy emitted by the ablation device according to the lesion type at the lesion position; and identifying the regional property of the region of interest where the ablation catheter is located according to the real-time image, and adjusting the operating state of the imaging device based on the regional property.

[0038] As a further improvement of the present application, when the regional property is a complex property, the imaging device is controlled to operate in real time, the imaging device acquires the real-time image of the region of interest in real time through the ablation catheter, and the orientation of the ablation catheter is adjusted based on the real-time image.

[0039] When the regional property is a simple property, the imaging device is controlled to acquire the real-time image of the region of interest after the ablation device ablates for a preset time or completes ablation, and the ablation effect is evaluated.

[0040] To achieve the above-mentioned purposes, the present application further provides an ablation system for performing the use method of the ablation system as described above, the ablation system comprising:

[0041] an ablation device comprising an ablation catheter, an ablation light source, and a light beam transmission optical path; the ablation light source provides an ablation light beam and transmits it to the ablation catheter through the light beam transmission optical path to complete lesion ablation;

[0042] an imaging device comprising an OCT imaging light source and an interferometer assembly for providing an imaging light beam;

[0043] a coupling device for combining the imaging light beam of the imaging device and the ablation light beam of the ablation device, and coupling them into an optical fiber in the ablation catheter;

[0044] a driving device for generating a voltage signal and acting on an actuator in the ablation catheter through a conductive cable, and driving the actuator to generate displacement;

[0045] a control device for controlling the operation of the imaging device and the ablation device to acquire an image of a region of interest through the imaging device, and to complete lesion ablation at a lesion position through the ablation device.

[0046] As a further improvement of the present application, the ablation system further comprises a calibration device;

[0047] The calibration device is used to collect the front-end light beam scanning trajectory coordinates of the ablation catheter for calibrating the image distortion.

[0048] As a further improvement of the present application, the ablation light source is a laser light source, the wavelength of the ablation light source is ultraviolet to infrared light, and the pulse width can be femtosecond to continuous light.

[0049] The present application has the following beneficial effects:

[0050] The ablation system of the present application is highly integrated, and facilitates the application of the ablation system. At the same time, by controlling the ablation system to calibrate the calibration device before ablation, the accuracy of the imaging device can be ensured, and then the image collected by the imaging device can be used to accurately judge the properties of the region of interest or the properties of the lesion position in the region of interest. Further, by controlling the cooperation between the imaging device and the ablation device, the image of the working area can be obtained in real time by the imaging device, which facilitates the ablation of the ablation device. At the same time, the ablation effect can be evaluated by the imaging device after ablation, which ensures the safety and completeness of the ablation. BRIEF DESCRIPTION OF DRAWINGS

[0051] Figure 1 is a structural schematic diagram of the ablation system of the present application.

[0052] Figure 2 is Figure 1 is a structural schematic diagram of the ablation catheter in the present application.

[0053] Figure 3 is a flow chart of the use method of the ablation system of the present application. DETAILED DESCRIPTION

[0054] The embodiments of the present application are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the accompanying drawings are exemplary and are intended to explain the present application, and cannot be understood as a limitation of the present application.

[0055] In the description of the present application, it should be understood that the terms "first", "second" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first", "second" can be explicitly or implicitly included one or more of the features. In the description of the present application, the meaning of "a plurality of" is two or more, unless otherwise specifically limited.

[0056] In the present application, unless otherwise specifically defined and limited, the terms "mounting", "connection", "connection", "fixing" and other terms should be understood broadly, for example, it can be fixed connection, or detachable connection, or integral; it can be mechanical connection, or electrical connection; it can be directly connected, or indirectly connected through intermediate medium, it can be the internal communication of two elements or the interaction relationship of two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific situation.

[0057] In order to make the purpose, technical scheme and advantages of the present application more clear, the present application will be described in detail below with reference to the drawings and specific embodiments.

[0058] When the atherosclerotic lesion develops to a certain extent, the complete occlusion of the blood vessel may occur, which is called chronic total occlusion lesion (CTO); in the clinical treatment of CTO lesion, a guide wire puncture is needed first, and the difficulty lies in breaking through the proximal fibrous cap of CTO lesion. However, the proximal fibrous cap is not clear in the position under the contrast, and is often accompanied by hard calcification, at this time, if the puncture is performed blindly, it is very likely to cause arterial perforation; if a small hole can be ablated at the fibrous cap in combination with real-time intraluminal image, so as to provide a puncture breakthrough point for the guide wire, the probability of arterial perforation and dissection will be reduced.

[0059] The ablation system 100 provided by the present application can accurately control the ablation direction and volume through the imaging device 2 when using the ablation device 1 to ablate the CTO fibrous cap, so as to ultimately reduce the probability of vascular wall damage and other adverse complications.

[0060] Please refer to Figure 1 As shown in the figure, the ablation system 100 provided by the present application comprises: an ablation device 1, an imaging device 2, a coupling device 3 and a control device 4, the ablation system 100 further comprises a driving device 5 and a calibration device 6, wherein the control device 4 is used for controlling the ablation device 1 and the imaging device 2 to run, so as to acquire the image of the region of interest through the imaging device 2, and complete the lesion ablation of the lesion position through the ablation device 1.

[0061] The ablation device 1 comprises an ablation catheter 11, an ablation light source 12 and a light beam transmission light path 13; wherein the ablation light source 12 provides an ablation light beam and transmits the ablation light beam to the ablation catheter 11 through the light beam transmission light path 13 to complete lesion ablation. Please refer to Figure 2 As shown in the figure, the ablation catheter 11 comprises a front-end rigid part and a rear-end flexible part.

[0062] Specifically, the front-end rigid part comprises a shell 111, an actuator 112 and a fiber cantilever 113, wherein the shell 111 is used to fix the actuator 112, so that the actuator 112 and the fiber cantilever 113 are coaxial or approximately coaxial in the shell 111. In the present disclosure, the actuator 112 can be any one of a piezoelectric actuator, a 2D piezoelectric ceramic, a piezoelectric vibrator and a piezoelectric bending sheet, and a piezoelectric ceramic tube or a 2D piezoelectric ceramic can be preferred to realize the scanning of the fiber cantilever 113 in two directions. It should be noted that only the piezoelectric actuator is taken as an example in the present disclosure, and in other embodiments of the present disclosure, the actuator for driving the fiber cantilever 113 can also be an electromagnetic type, an electrostatic type or other types of actuators.

[0063] One end of the fiber cantilever 113 is fixed on the actuator 112, and the other end extends a certain length away from the actuator 112 to be suspended and centrally fixed in the internal cavity of the shell 111; further, the actuator 112 can drive the fiber cantilever 113 to produce displacement and drive the fiber cantilever 113 to vibrate at a resonant frequency under the drive of the voltage. In fact, the longer the length of the fiber cantilever 113 is, the greater the vibration amplitude will be, but the vibration amplitude will be reduced after it becomes large, and too low resonant frequency may cause uneven vibration scanning of the fiber, affecting the imaging effect of the imaging device 2 and the ablation effect of the ablation device 1. Therefore, in the present disclosure, the length of the fiber cantilever 113 is generally several millimeters to several tens of millimeters. It should be noted that only the example of the actuator 112 driving the fiber cantilever 113 to vibrate at a resonant frequency is taken as an example in the present disclosure, and in other embodiments of the present disclosure, the fiber cantilever 113 can also vibrate at other frequencies under the drive of the actuator 112, that is, the frequency at which the fiber cantilever 113 vibrates under the drive of the actuator 112 can be selected according to actual needs.

[0064] In the present disclosure, the front-end rigid part further comprises a focusing structure arranged at the extended end of the fiber cantilever 113, for focusing the light beam passing through the fiber cantilever 113. Please refer to Figure 2 As shown in the figure, in a preferred embodiment of the present disclosure, the focusing structure comprises at least one of a fiber probe 114 and a micro lens 115.

[0065] Specifically, the optical fiber probe 114 is a fiber lens for focusing the light beam. In a preferred embodiment of the present disclosure, the optical fiber probe 114 is a fiber ball lens formed at the end of the optical fiber cantilever 113, which is formed by a coreless optical fiber extending from the end of the optical fiber cantilever 113 by a certain length through sintering, thereby achieving focusing of the light beam. In other embodiments of the present disclosure, the optical fiber probe 114 can also be a micro lens fixed at the end of the optical fiber cantilever 113 by welding or bonding, such as a fiber lens or a micro GRIN lens, a 3D printed lens, a fiber superlens, and a fiber ball lens or a fiber GRIN lens can be preferred for simplicity.

[0066] The micro lens 115 is fixed at the most front end of the shell 111, which is used to expand the scanning range of the light beam, so as to expand the ablation range to the outer diameter of the catheter. In the present disclosure, the micro lens 115 can be one of a GRIN lens, a superlens, and a composite lens, and the preferred micro lens 115 is a GRIN lens, which can effectively reduce the difficulty of manufacturing the ablation catheter 11.

[0067] It should be noted that when the front rigid part includes the optical fiber probe 114 and / or the micro lens 115, the actuator 112, the optical fiber cantilever 113, the optical fiber probe 114, and the micro lens 115 are coaxial or approximately coaxial in the shell 111.

[0068] The rear flexible part includes the optical fiber 116, the conductive cable 117, and the sheath tube 118. Specifically, the optical fiber 116, the conductive cable 117, and the sheath tube 118 in the rear flexible part have a certain length, and in the present disclosure, the total length of the optical fiber 116, the conductive cable 117, and the sheath tube 118 is about 1-2 m to meet the application scenarios of vascular intervention surgery.

[0069] The optical fiber 116 is an extension of the optical fiber cantilever 113, that is, the optical fiber cantilever 113 is part of the optical fiber 116; in the present disclosure, the optical fiber 116 can be any one of a single-mode optical fiber, a double-clad optical fiber, and a photonic crystal optical fiber, and the specific selection of the optical fiber 116 can be determined according to the type of the ablation light source 12.

[0070] The conductive cable 117 is fixed at the end of the extension of the actuator 112, which is used to transmit a voltage signal, and the number is not limited to one; the sheath tube 118 is used to protect the optical path and the circuit inside the ablation catheter 11.

[0071] During the operation of the ablation catheter 11, the surface of the actuator 112 (here specifically a piezoelectric ceramic tube) has four partitioned electrodes and a grounding electrode, and each electrode is connected to a conductive cable. When the driving device 5 applies a voltage of a certain frequency to the actuator 112 through the conductive cable, the actuator 112 will produce displacement in two directions, and drive the optical fiber cantilever 113 to perform a scanning motion at a resonant frequency, and the scanning trajectory is controlled by the applied voltage. The miniature lens 115 at the front end of the ablation catheter 11 further expands the scanning range of the light beam, so that the ablation range of the ablation catheter 11 is not less than the outer diameter size of the shell 111.

[0072] The ablation light source 12 is used to act on the lesion position of the region of interest through the ablation catheter 11 to achieve ablation of the lesion. In the present disclosure, the laser light source wavelength selected by the ablation light source 12 can be ultraviolet to infrared light, and the pulse width can be femtosecond to continuous light; preferably, the ablation light source 12 is an ultrafast laser or a light source with a pulse width less than 100 ps, so as to provide a light beam with high peak power density to have a better ablation effect on calcified plaques.

[0073] The light beam transmission optical path 13 can be flexibly set according to requirements, and should not only realize the function of light beam transmission, but also realize one or several functions such as light beam shaping, pulse adjustment, light spot homogenization, and energy adjustment.

[0074] The imaging device 2 includes an OCT imaging light source 21 and an interferometer assembly 22 for providing an imaging light beam. Specifically, the imaging light beam emitted by the OCT imaging light source 21 and the ablation light beam emitted by the ablation device 1 enter the coupling device 3 after passing through the interferometer assembly 22 and the light beam transmission optical path 13, respectively, and the bicomponent mirror in the coupling device 3 realizes the beam combination of the imaging light beam and the ablation light beam, and focuses into the optical fiber 116 of the ablation catheter 11.

[0075] The control device 4 can include one or several of a capture card, a high-performance computer, a display screen, and an integrated assembly, and mainly realizes the functions of OCT image acquisition, processing, analysis, and display, and sends control commands to the driving device 5, the calibration device 6, the imaging device 2, and the ablation device 1 to make them normally operate, and receives feedback signals thereof.

[0076] The driving device 5 can include a signal generator, a voltage amplifier, or other devices capable of realizing signal generation and amplification, which is connected to the conductive cable 117 of the ablation catheter 11 to provide the actuator 112 with the voltage amplitude and waveform required for operation.

[0077] The calibration device 6 can adopt a position sensor or other device capable of collecting the position coordinates of the light beam, and the calibration device 6 can be arranged to collect the scanning track coordinates of the light beam emitted by the ablation catheter 11 in one cycle in advance and provide the control device 4 to assist in image calibration, so as to avoid using the scanning track of the ablation catheter 11 calculated theoretically to reconstruct the image, thereby eliminating the image distortion.

[0078] Referring to Figure 3 The present application also provides a method for using the ablation system, and the ablation system 100 can perform the method for using the ablation system to complete the ablation of the lesion in the region of interest.

[0079] Specifically, the method for using the ablation system includes the following steps:

[0080] S1, controlling the imaging device 2 to operate, the imaging device 2 acquiring the real-time image of the region of interest through the optical fiber 116, and guiding the ablation catheter 11 to move to the region of interest;

[0081] S2, positioning and identifying the lesion position in the region of interest according to the real-time image, and adjusting the working position of the ablation catheter 11 to make the working position overlap with the lesion position;

[0082] S3, controlling the ablation device 1 to perform the ablation work, so that the ablation light beam and / or the imaging light beam act on the lesion position through the optical fiber 116 to ablate and / or image the lesion at the lesion position.

[0083] In a preferred embodiment of the present disclosure, S1 is further preceded by S0, specifically, S0 is: under the control of a preset voltage, the actuator 112 in the ablation catheter 11 drives the optical fiber cantilever 113 in the ablation catheter 11 to make scanning motion, and moves the ablation catheter 11 to face the calibration device 6, thereby completing the calibration of the ablation device 1.

[0084] The following description will be made in detail with respect to S0-S3 of the method for using the ablation system.

[0085] In S0, the calibration of the ablation device 1 is specifically that the actuator 112 drives the optical fiber cantilever 113 to make scanning motion under the control of a preset voltage, the scanning track can be spiral, and the ablation catheter 11 is moved to face the position sensor in the calibration device 6, the position sensor collects the scanning track coordinates of the light beam at the head end of the ablation catheter 11 in one cycle and provides the control device 4 for image calibration.

[0086] As mentioned before, the calibration device 6 includes a position sensor, which can collect the scanning track coordinates of the light beam emitted by the front end of the ablation catheter 11 in one motion cycle, and realize the calibration of the ablation device 1 through image calibration.

[0087] S1 specifically, based on the image of the region of interest collected by the imaging device 2, guiding the ablation device 1 to move to the region of interest; the imaging beam is emitted through the head end of the ablation catheter 11, and the interference signal returned by the region is received, and the control device 4 collects the interference signal and processes it in real time to obtain the forward real-time three-dimensional OCT image of the region. Specifically, when the imaging device 2 is collecting images of the region of interest, the driving device 5 drives the actuator 112 to drive the optical fiber cantilever 113 to make scanning motion, so that the imaging beam realizes the imaging of the region of interest from point to plane, at the same time, when the actuator 112 drives the optical fiber cantilever 113 to move for imaging, the control voltage of the actuator 112 is consistent with the voltage during the calibration of the operation of the ablation device 1, so as to ensure the accuracy of imaging; of course, the control voltage of the actuator 112 during imaging can also be different from the voltage during the calibration of the operation of the ablation device 1.

[0088] S2 specifically, analyzing the characteristics of the real-time image, if the image field of view deviates from the lesion, it is a normal blood vessel wall, then according to the image to guide the adjustment of the ablation catheter 11 to the lesion, and analyze the lesion type; Specifically, the real-time image is the real-time three-dimensional OCT image obtained by the imaging device 2 through the ablation device 1 in the forward direction of the moving direction of the ablation device 1, by analyzing the image characteristics of the real-time three-dimensional OCT image, whether the ablation device 1 deviates from the lesion position during the moving process is judged, the ablation device 1 is guided and adjusted to move to the lesion position, and the lesion type at the lesion position is analyzed.

[0089] S3 specifically, controlling the ablation device 1 to perform ablation work, including:

[0090] Adjusting the energy of the ablation beam emitted by the ablation device 1 according to the type of lesion; when the region of interest where the ablation device 1 is located is identified according to the real-time image, the running state of the imaging device 2 is adjusted based on the region property.

[0091] Specifically, when the region property is complex, control the imaging device 2 to run in real time, the imaging device 2 obtains the real-time image of the region of interest in real time through the ablation device 1 (specifically the ablation catheter 11), and adjusts the orientation of the ablation device 1 based on the real-time image; Specifically, when the region property is complex, the blood vessels at the location of the region of interest are in complex conditions such as twisting and angling, the simultaneous operation of the imaging device 2 can be monitored in real time, when the lesion ablation in the image field of view is complete and the blood vessel wall is about to be damaged, the orientation of the ablation catheter 11 is adjusted in time according to the image information.

[0092] When the region property is a simple property, the control imaging device acquires a real-time image of the region of interest after the ablation device 1 ablates for a preset time or after the ablation is completed, and evaluates the ablation effect; specifically, when the region property is a simple property, the region of interest is in a straight blood vessel segment, or only the lesion is seen in the image field of view without seeing the blood vessel wall, the imaging device 2 can not be operated at the same time, and the ablation effect evaluation can be performed after a period of ablation.

[0093] That is, in the present disclosure, the working state of the imaging device 2 can be switched as needed when the ablation device 1 is working.

[0094] Similarly, when the control device 4 controls the ablation device 1 to perform ablation work, the control device 4 also controls the driving device 5 to drive the actuator 112 to drive the optical fiber cantilever 113 to perform scanning motion, so that the ablation light beam acts on the lesion position of the region of interest from point to plane, ensuring the integrity of the lesion ablation. In a preferred embodiment of the present disclosure, when the actuator 112 drives the optical fiber cantilever 113 to move for ablation work, the control voltage of the actuator 112 is consistent with the voltage when the ablation device 1 is calibrated, so as to ensure that the ablation light beam can accurately act on the lesion position; of course, in other embodiments of the present disclosure, the control voltage of the actuator 112 can also be different from the voltage when the ablation device 1 is calibrated.

[0095] Further, when the ablation device 1 and the imaging device 2 work at the same time, since the ablation device 1 and the imaging device 2 are arranged in the same optical path, the coupling device 3 combines the ablation light beam and / or the imaging light beam, the actuator 112 drives the optical fiber cantilever 113 to perform scanning motion, so that the imaging light beam and the ablation light beam act on the lesion position of the region of interest from point to plane, ensuring the accuracy of imaging while ensuring the integrity of lesion ablation. Similarly, the control voltage of the actuator 112 when driving the optical fiber cantilever 113 to move in this process can be consistent with or different from the voltage when the ablation device 1 is calibrated.

[0096] In addition, it needs to be explained that in the present disclosure, only the ablation system 100 / the use method of the ablation system is taken as an example for intravascular plaque ablation, and of course in other embodiments of the present disclosure, the ablation system 100 / the use method of the ablation system can also be used in other fields, such as guiding tumor or cancer cell removal, guiding bone spur removal or bone cutting, or other suitable OCT imaging guided ablation applications.

[0097] Further, in the specification of the present disclosure, only the imaging device 2 is taken as an OCT imaging device for example, but the imaging device 2 can be changed to a fluorescence imaging device based on the same ablation device 1, at this time, although it is not suitable for intravascular guidance for plaque ablation, it can be applied to other ablation applications guided by fluorescence imaging, such as guiding tumor or cancer cell removal. Even, the imaging device of the present application can be OCT-fluorescence dual imaging.

[0098] In summary, the ablation system 100 of the present application is configured by placing the ablation device 1 and the imaging device 2 in the same optical path, and guiding the ablation device 1 to move to the lesion position of the region of interest by the imaging device 2 in real time; at the same time, when the lesion is ablated by the ablation device 1, the ablation of the lesion position can also be monitored by the imaging device 2, so that the ablation system 100 is highly integrated, and the application of the ablation system is facilitated. At the same time, by controlling the ablation device 1 to calibrate the work by the calibration device 6 before ablation, the accuracy of the imaging device 2 can be ensured, and then the image acquired by the imaging device 2 can be used to accurately judge the properties of the region of interest or the properties of the lesion in the region of interest; further, by controlling the cooperation between the imaging device 2 and the ablation device 1, the image of the working area can be obtained by the imaging device 2 in real time, which facilitates the ablation of the ablation device 1; at the same time, the ablation effect can also be evaluated by the imaging device 2 after ablation, which ensures the safety and completeness of ablation.

[0099] The above embodiments are only used to illustrate the technical solutions of the present application rather than limit the present application. Although the present application has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present application can be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present application.

Claims

1. An ablation system, characterized by, The application relates to an ablation system, which comprises an ablation device, an imaging device, a coupling device, a driving device, a control device and a calibration device. The ablation device comprises an ablation catheter, an ablation light source and a light beam transmission path; the ablation light source provides an ablation light beam and transmits the ablation light beam to the ablation catheter through the light beam transmission path to complete lesion ablation. The ablation catheter comprises a front-end rigid part and a rear-end flexible part; the front-end rigid part comprises at least a shell, an actuator and a fiber cantilever; the rear-end flexible part comprises a fiber, a conductive cable and a sheath. The fiber cantilever is a part of the fiber; the fiber extends through the actuator to form the fiber cantilever on one side of the actuator; one end of the fiber cantilever is fixed on the actuator, and the other end extends away from the actuator. The imaging device is used for providing an imaging light beam. The coupling device is used for coupling the imaging light beam of the imaging device and the ablation light beam of the ablation device and coupling them into the fiber in the ablation catheter. The driving device is used for generating a voltage signal and acting on the actuator in the ablation catheter through the conductive cable to drive the actuator to generate displacement. The control device is used for controlling the imaging device and the ablation device to operate, acquiring an image of a region of interest through the imaging device and completing lesion ablation at a lesion position through the ablation device; the ablation system further comprises a calibration device; the calibration device is used for collecting front-end light beam scanning track coordinates of the ablation catheter to calibrate image distortion; the calibration device comprises a position sensor which can collect scanning track coordinates of the light beam emitted from the front end of the ablation catheter in one motion cycle and realize calibration of the ablation device through image calibration.

2. The ablation system of claim 1, wherein, The control device is used for controlling the imaging device to operate; the imaging device acquires a real-time image of the region of interest through the fiber and guides the ablation catheter to move to the region of interest. The control device can position and identify a lesion position in the region of interest based on the real-time image, adjust a working position of the ablation catheter, and make the working position overlap with the lesion position. The control device controls the ablation device to perform ablation work, so that the ablation light beam and / or the imaging light beam act on the lesion position through the fiber to ablate and / or image the lesion at the lesion position.

3. The ablation system of claim 2, wherein, The control device performs image feature analysis on the real-time image, judges whether the ablation device deviates from the lesion position during movement, guides and adjusts the ablation catheter to move to the lesion position, and analyzes a lesion type at the lesion position based on the real-time image.

4. The ablation system of claim 1, wherein, The calibration device calibrates the ablation device, controls the actuator in the ablation catheter to drive the fiber cantilever in the ablation catheter to perform scanning movement under a preset voltage, moves the ablation catheter to face the calibration device, and completes calibration of the ablation device.

5. The ablation system of claim 1, wherein, The control device controls the ablation device to perform ablation work, which comprises: Adjusting the ablation beam energy emitted by the ablation device according to the lesion type at the lesion position; and identifying the regional property of the region of interest where the ablation catheter is located according to the real-time image, and adjusting the operating state of the imaging device based on the regional property.

6. The ablation system of claim 5, wherein, When the regional property is a complex property, controlling the imaging device to operate in real time, the imaging device acquiring the real-time image of the region of interest through the ablation catheter in real time, and adjusting the orientation of the ablation catheter based on the real-time image; When the regional property is a simple property, controlling the imaging device to acquire the real-time image of the region of interest after the ablation device ablates for a preset time or completes ablation, and evaluating the ablation effect.

7. The ablation system of claim 1, wherein, The imaging device comprises an OCT imaging light source and an interferometer assembly.

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