Device for constructing intervertebral disc degeneration model by using mouse simulation

Abstract

The invention provides a device for constructing an intervertebral disc degeneration model by using mouse simulation, and belongs to the technical field of medical research. Comprising a mounting base plate, a supporting rod is connected to the middle of the top of the mounting base plate, a top seat is fixedly connected to the top of the supporting rod, and a ring seat is fixedly connected to the inner side of the top seat. The body clamping mechanism can accurately clamp an animal body, is matched with an electric push rod to realize bending or unfolding of the body, and is matched with the limb positioning mechanism to improve the experiment suitability and assist in simulating the pathological process of human intervertebral disc degeneration, the limb positioning mechanism fixes the limbs of the animal through antiskid plates, and the device can adapt to animals with different sizes and is high in practicability. The rotating shaft design avoids animal limb fracture, the angle adjusting assembly and the arc-shaped displacement assembly enable the animal limbs to flexibly swing and move up and down, the convenience and the adjusting adaptation performance of the device are improved, and more accurate data and reliable experiment conditions are provided for lumbar vertebra pathological research on the whole.

Description

Technical Field

[0001] The present invention relates to the field of medical research technology, and more specifically, to a device for constructing an intervertebral disc degeneration model by simulating mice. Background Art

[0002] Degeneration of the intervertebral disc in the human body is a very common pathological process of spinal diseases. The intervertebral disc is located between two adjacent vertebrae and is mainly composed of the nucleus pulposus, the annulus fibrosus and the cartilage endplate. Under the influence of various factors, the intervertebral disc will gradually degenerate. Among them, the continuous increase in age is an important factor. As time goes by, the various functions of the human body gradually decline, and the intervertebral disc is no exception. Long-term poor posture, such as sitting for a long time, hunching over, etc., will cause the intervertebral disc to continue to bear abnormal pressure and accelerate its degeneration process. Excessive physical labor will bring a huge burden to the intervertebral disc. Repeated pressure and damage can easily lead to cracks in the annulus fibrosus, which will greatly reduce the stability of the intervertebral disc. In addition, trauma may also directly cause damage to the intervertebral disc, leading to degeneration.

[0003] At present, in the process of exploring the pathological process of human intervertebral disc degeneration, a spinal disease, it is usually necessary to use models for simulation. In the existing simulation practice, some vertebrates that are relatively similar to the human body are often selected for simulation tests, such as rabbits, mice and other vertebrate mammals. However, the existing auxiliary degeneration model device has many limitations during practical application. On the one hand, the device can only position the limbs of the animal. After positioning, it is usually impossible to flexibly adjust the limbs and body of the experimental simulation animal to bend. Obviously, such a device cannot achieve the adjustment of complex movements such as flexion and extension, left and right lateral flexion, and left and right rotation of the experimental animal's body. On the other hand, due to the inability to adjust these complex movements, it is difficult to reproduce the etiology, pathogenesis and pathological changes of intervertebral disc degeneration. At the same time, it is impossible to accurately select the intended intervention segment according to the experimental needs. There are obvious deficiencies in the controllability and standardization of the model. In summary, the existing technical means do have certain defects and deficiencies, and it is urgent to improve and perfect them to better meet the needs of research on the pathological process of human intervertebral disc degeneration. Summary of the invention

[0004] In view of the problem in the prior art that the flexibility of the animal's limbs and waist cannot be flexibly adjusted after fixation when constructing an intervertebral disc degeneration model, making it inconvenient to conduct pathological research, the purpose of the present invention is to provide a device for simulating the construction of an intervertebral disc degeneration model using mice.

[0005] To solve the above problems, the present invention adopts the following technical solutions:

[0006] A device for constructing an intervertebral disc degeneration model using mice for simulation, comprising: a mounting base plate, a support rod connected to the middle of the top of the mounting base plate, a top seat fixedly connected to the top of the support rod, a ring seat fixedly connected to the inner side of the top seat, a body clamping mechanism fixedly connected to the inner side of the ring seat, a fixing frame fixedly connected to the outer side of the ring seat in an annular arrangement with equal intervals, and a limb positioning mechanism fixedly connected to the top of each fixing frame;

[0007] The limb positioning mechanism includes a fixing plate, which is mounted on the top outer end of the fixing frame by screws, the top of the fixing plate is fixedly connected to an arc displacement component, the top of the arc displacement component is fixedly connected to an angle adjustment component, the top of the angle adjustment component is fixedly connected to a linear displacement component, and the inner end of the linear displacement component is fixedly connected to a positioning component.

[0008] Optionally, mounting holes are provided on both sides of the top of the mounting base plate, the mounting holes are configured as countersunk holes, and the outer corners of the base plate, the top seat and the ring seat are configured as arc shapes.

[0009] It also includes that the arc displacement assembly includes a support leg, the support leg is fixedly connected to the top of the fixed plate, the top of the support leg is fixedly connected to an arc frame, the inside of the arc frame is slidably connected to an arc slider, one side of the arc slider is fixedly connected to a drive group, the drive group is connected to the arc frame, and one side of the drive group is connected to the bottom of the angle adjustment assembly.

[0010] Optionally, the driving group includes a base plate and an arc-shaped rack, the base plate is fixedly connected to the top of the arc-shaped slider, the side of the base plate close to the ring seat is fixedly connected to a mounting arm, the bottom of the mounting arm is fixedly connected to a first motor, the output end of the first motor passes through the fixed arm and is fixedly connected to a gear, the arc-shaped rack is fixedly connected to the side of the arc frame close to the ring seat, the gear and the arc-shaped rack are meshingly connected, and one side of the base plate is connected to the angle adjustment assembly.

[0011] Optionally, the angle adjustment assembly includes a connecting block and a first articulated seat, the connecting block is fixedly connected to the top middle of the base plate, the first articulated seat is fixedly connected to the bottom outer end of the base plate, the top of the connecting block is hinged with a second articulated seat, the top of the second articulated seat is connected to the bottom of the linear displacement assembly, the base plate is hinged with a first electric push rod through the first articulated seat, the outer end of the first electric push rod is hinged with a third articulated seat, the top of the third articulated seat is connected to the bottom outer end of the linear displacement assembly.

[0012] Optionally, the linear displacement assembly includes a side rail, an end of the bottom of the side rail close to the ring seat is fixedly connected to the top of the second hinge seat, an end of the bottom of the side rail away from the ring seat is connected to the top of the third hinge seat, the outer end of the side rail is fixedly connected to the second motor, the output end of the second motor passes through the side rail and is fixedly connected to a one-way screw rod, the one-way screw rod is rotatably connected to the inside of the side rail, the outer surface of the one-way screw rod is threadedly connected to a sliding block, the outer side of the sliding block is fixedly connected to a connecting arm, and the end of the connecting arm away from the second motor is connected to the positioning assembly.

[0013] Optionally, the positioning assembly includes a rotating shaft, which is rotatably connected to the inner end of the connecting arm away from the end of the second motor, and a positioning frame is fixedly connected between the inner sides of the rotating shaft, and a hand-tightening screw is threadedly connected to the top of the positioning frame, and the end of the hand-tightening screw passes through the positioning frame and is rotatably connected to a splint.

[0014] Optionally, the body clamping mechanism includes a mounting base, the mounting base is fixedly connected to the inner bottom of the ring seat, a second electric push rod is fixedly connected to the inner middle part of the mounting base, and a clamping assembly is fixedly connected to the top of the second electric push rod.

[0015] Optionally, the clamping assembly includes a socket plate, which is fixedly connected to the top of the second electric push rod, and a guide rail is fixedly connected to the middle of the socket plate, one end of the guide rail is fixedly connected to a third motor, and the output end of the third motor passes through the guide rail and is fixedly connected to a bidirectional screw rod, the threads at both ends of the bidirectional screw rod have opposite rotation directions, the bidirectional screw rod is rotatably connected to the inside of the guide rail, both ends of the bidirectional screw rod are threadedly connected to displacement blocks, the top of the displacement block is fixedly connected to a clamping arm, and the outer end side surface of the clamping arm is semi-arc-shaped.

[0016] Optionally, the positioning assembly also includes a support rod, which is fixedly connected to both sides of the top of the splint, and the top of the support rod passes through the positioning frame. The bottom of the splint and the bottom of the positioning frame are fixedly connected with a toothed anti-skid plate, and the toothed anti-skid plate is made of silicone material.

[0017] Compared with the prior art, the technical solution provided by the present invention has at least the following beneficial effects:

[0018] In the above scheme, by setting up a body clamping mechanism, after the body of the experimental animal is placed on the top of the receiving plate, the third motor is started to drive the bidirectional screw to rotate. Since the threads at both ends of the screw have opposite rotation directions, the displacement blocks at both ends can be driven to slide back and forth in the guide rail, thereby driving the clamping arm to move back and forth, thereby achieving accurate positioning and clamping of the animal body. During use, the second electric push rod is started, and when it is extended, it pushes the receiving plate upward to make the animal body unfold. When it is contracted, the animal body is pulled downward to make it bend. In conjunction with the limb positioning mechanism, the limbs and lumbar vertebrae of the experimental animal can be flexibly adjusted and swung, which greatly improves the adaptability of the device in experimental exploration, which helps to more realistically simulate the pathological process of human intervertebral disc degeneration and provide more accurate data and more reliable experimental conditions for research.

[0019] Through the limb positioning mechanism, after the limbs of the experimental animal are placed in the positioning frame, the hand-tightened screws can be twisted to drive the splint to move down, and the support rod plays a supporting and guiding role, so that the two toothed anti-skid plates made of silicone material are close to each other and the animal's limbs are firmly fixed. After the positioning is completed, the second motor is started to drive the one-way screw to rotate, driving the sliding block to slide on the inside of the side rail, thereby driving the connecting arm and the positioning frame to move, which can flexibly adapt to animals of different sizes. At the same time, due to the setting of the rotating shaft, the positioning frame can adaptively rotate during the adjustment process to avoid fractures of the animal's limbs and effectively protect the experimental animals. This mechanism improves the overall adaptability of the device, ensures the stable fixation of the animal's limbs during the experiment, and provides a guarantee for the smooth progress of the research.

[0020] By setting an angle adjustment component and an arc displacement component, when the animal's limbs are fixed, the first motor is started to drive the gear to rotate. Since the gear is meshed with the arc rack, the arc slider is driven to slide inside the arc frame, so that the positioning frame is displaced in an arc shape, which assists in flexibly adjusting the reciprocating lateral swing of the animal's limbs. During the swinging, the first electric push rod is started to promote the rotational displacement of the side rails. Through the coordinated rotation of the first articulated seat, the second articulated seat, the third articulated seat and the connecting block, the rotation of the side rails can be flexibly adjusted, and then the side rail angle of the linear displacement component can be adjusted. After the angle is adjusted, the stroke of the linear displacement component changes, and the up and down movement of the animal's limbs can be adjusted. This further improves the convenience of using the device, so that the animal's limbs can flexibly swing and displace in any direction after positioning is completed, greatly improving the adjustment and adaptation performance of the device during lumbar pathology research. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable those skilled in the relevant art to make and use the invention.

[0022] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0023] Figure 2 It is a bottom view structural schematic diagram of the present invention;

[0024] Figure 3 It is a schematic diagram of the top view structure of the present invention;

[0025] Figure 4 It is a schematic diagram of the structure of the body clamping mechanism and the limb positioning mechanism of the present invention;

[0026] Figure 5 It is a schematic diagram of the top view of the body clamping mechanism of the present invention;

[0027] Figure 6 It is a bottom view structural diagram of the body clamping mechanism of the present invention;

[0028] Figure 7 It is a schematic diagram of the top view of the limb positioning mechanism of the present invention;

[0029] Figure 8 This is a bottom view structural diagram of the limb positioning mechanism of the present invention;

[0030] Fig. 9 It is a side view structural schematic diagram of the limb positioning mechanism of the present invention;

[0031] Fig.10 For the present invention Figure 1 A is an enlarged structural diagram of FIG.

[0032] [reference numerals]

[0033] 1. Install the base plate; 2. Support rod; 3. Top seat; 4. Ring seat;

[0034] 5. Body clamping mechanism; 51. Mounting base; 52. Second electric push rod;

[0035] 53. Clamping assembly; 531. Adapter plate; 532. Guide rail; 533. Third motor; 534. Bidirectional screw rod; 535. Displacement block; 536. Clamping arm;

[0036] 6. Fixed frame;

[0037] 7. Limb positioning mechanism; 71. Fixing plate;

[0038] 72, arc displacement assembly; 721, support leg; 722, arc frame; 723, arc slider;

[0039] 724, driving group; 7241, substrate; 7242, arc-shaped rack; 7243, mounting arm; 7244, first motor; 7245, gear;

[0040] 73, angle adjustment assembly; 731, connection block; 732, first hinge seat; 733, second hinge seat; 734, first electric push rod; 735, third hinge seat;

[0041] 74, linear displacement assembly; 741, side rail; 742, second motor; 743, one-way screw rod; 744, sliding block; 745, connecting arm;

[0042] 75, positioning assembly; 751, rotating shaft; 752, positioning frame; 753, hand screw; 754, clamping plate; 755, supporting rod; 756, toothed anti-skid plate;

[0043] 8. Mounting hole.

[0044] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0045] The present invention is described in detail below in conjunction with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for more specific description of the embodiments, and are not intended to specifically limit the present invention.

[0046] It should be noted that the references to "one embodiment", "an embodiment", "an exemplary embodiment", "some embodiments" and the like in the specification indicate that the embodiments described may include specific features, structures or characteristics, but not every embodiment may include the specific features, structures or characteristics. In addition, when a specific feature, structure or characteristic is described in conjunction with an embodiment, it should be within the knowledge of a person skilled in the art to implement such feature, structure or characteristic in conjunction with other embodiments (whether or not explicitly described).

[0047] In general, a term can be understood, at least in part, from its use in context. For example, depending, at least in part, on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular sense, or can be used to describe a combination of features, structures, or characteristics in the plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey an exclusive set of factors, but can instead, depending, at least in part, on the context, allow for the presence of other factors that are not necessarily explicitly described.

[0048] It will be understood that the meanings of “on,” “over,” and “above” in the present invention should be interpreted in the broadest manner, so that “on” not only means “directly on” something, but also includes the meaning of being “on” something with intervening features or layers therebetween, and “on” or “over” not only means “on” or “above” something, but also includes the meaning of being “on” or “above” something with no intervening features or layers therebetween.

[0049] Additionally, spatially relative terms such as "under," "beneath," "lower," "above," "upper," and the like may be used herein for descriptive convenience to describe the relationship of one element or feature to another element or features, as shown in the accompanying drawings. Spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the accompanying drawings. The device may be oriented in other ways, and the spatially relative descriptors used herein may be similarly interpreted accordingly.

[0050] like Figures 1 to 10 As shown, an embodiment of the present invention provides a device for constructing an intervertebral disc degeneration model using mice for simulation, comprising a mounting base plate 1, wherein a support rod 2 is fixedly connected to the top middle of the mounting base plate 1 in an evenly spaced 2*2 arrangement, a top seat 3 is fixedly connected to the top of the support rod 2, a ring seat 4 is fixedly connected to the inner side of the top seat 3, a body clamping mechanism 5 is fixedly connected to the inside of the ring seat 4, a fixing frame 6 is fixedly connected to the outer side of the ring seat 4 in an annular arrangement in an evenly spaced manner, and a limb positioning mechanism 7 is fixedly connected to the top of each of the fixing frames 6.

[0051] The limb positioning mechanism 7 includes a fixing plate 71, which is installed on the top outer end of the fixing frame 6 by screws. The top of the fixing plate 71 is fixedly connected with an arc displacement component 72, the top of the arc displacement component 72 is fixedly connected with an angle adjustment component 73, the top of the angle adjustment component 73 is fixedly connected with a linear displacement component 74, and the inner end of the linear displacement component 74 is fixedly connected with a positioning component 75. The support rods 2 arranged in 2*2 on the base plate 7241 provide stable support for the entire device to ensure that there will be no shaking during the experiment. The top seat 3 is firmly connected to the support rod 2, and the inner ring seat 4 provides an installation position for the body clamping mechanism 5, so that the mouse body can be stably clamped. The fixing frame 6 arranged in a ring shape with equal intervals outside the ring seat 4 provides a solid foundation for the limb positioning mechanism 7.

[0052] The fixing plate 71 in the limb positioning mechanism 7 is installed on the top outer end of the fixing frame 6 by screws, ensuring the firmness of the connection. The arc displacement component 72 thereon can realize the arc displacement adjustment of the mouse limbs, so that the limbs can be flexibly moved at different angles to better simulate the activities in the natural state. The angle adjustment component 73 can further adjust the angle of the limbs to meet different experimental requirements. The linear displacement component 74 can accurately control the position of the limbs and realize linear displacement adjustment. The positioning component 75 can firmly fix the mouse limbs to ensure that there will be no displacement during the experiment.

[0053] Overall, through the synergistic effect of its various parts, the device can provide precise, stable and flexible experimental conditions for simulating the construction of an intervertebral disc degeneration model using mice, which helps to improve the accuracy and reliability of the experiment and provides a powerful tool for in-depth research on the causes, pathogenesis and pathological changes of intervertebral disc degeneration.

[0054] like Figures 1 to 3 As shown, mounting holes 8 are provided on both sides of the top of the mounting base plate 1, and the mounting holes 8 are all set as countersunk holes. The outer edges and corners of the base plate, the top seat 3 and the ring seat 4 are all set as arc shapes. The mounting holes 8 opened on both sides of the top of the substrate 7241 are all set as countersunk holes, which have many advantages. The design of the countersunk holes allows the screw heads to sink into the holes when the device is installed and fixed, and will not protrude from the surface of the substrate 7241, thereby avoiding interference and potential dangers caused by the screw heads to the surrounding environment. At the same time, this design makes the device more flat and stable after installation, reducing the shaking or instability factors that may be caused by the protruding screw heads.

[0055] In addition, the outer corners of the base plate 7241, the top seat 3 and the ring seat 4 are all set to be arc-shaped, which also has many advantages. On the one hand, the arc-shaped outer corners improve the safety of the device. During operation, personnel are not easily scratched by sharp corners, reducing the probability of accidents. On the other hand, this design enhances the aesthetics of the device to a certain extent, making its appearance more smooth and natural. Moreover, the arc-shaped outer corners are more convenient during transportation and installation, and are not easy to scratch other objects or cause damage to themselves. At the same time, for using the device for mouse experiments, the arc-shaped design also reduces the risk of injury to mice and provides a safer experimental environment for mice.

[0056] like Figures 1 to 4 and Figures 7 to 10As shown, the arc displacement assembly 72 includes a support leg 721, the support leg 721 is fixedly connected to the top of the fixed plate 71, the top of the support leg 721 is fixedly connected to an arc frame 722, the inside of the arc frame 722 is slidably connected to an arc slider 723, one side of the arc slider 723 is fixedly connected to a drive group 724, the drive group 724 is connected to the arc frame 722, one side of the drive group 724 is connected to the bottom of the angle adjustment assembly 73, the drive group 724 includes a base plate 7241 and an arc rack 7242, the base plate 7241 is fixedly connected to the top of the arc slider 723, and the side of the base plate 7241 close to the ring seat 4 is fixedly connected to a mounting arm 7243, the bottom of the mounting arm 7243 is fixedly connected with a first motor 7244, the output end of the first motor 7244 passes through the fixed arm and is fixedly connected with a gear 7245, the arc-shaped rack 7242 is fixedly connected to the side of the arc frame close to the ring seat 4, the gear 7245 and the arc-shaped rack 7242 are meshed and connected, one side of the base plate 7241 is connected to the angle adjustment component 73, the support leg 721 stably fixes the arc-shaped frame 722 on the top of the fixed plate 71, providing solid support for the entire assembly, the arc-shaped slider 723 inside the arc-shaped frame 722 can slide smoothly, ensuring the smoothness of the movement, and the setting of the drive group 724 realizes the precise control of the arc-shaped slider 723.

[0057] The base plate 7241 in the driving group 724 provides a stable installation position for the mounting arm 7243 and the first motor 7244. After the first motor 7244 is started, its output end drives the gear 7245 to rotate. Since the gear 7245 is meshed with the arc-shaped rack 7242, the arc-shaped slider 723 can perform precise arc-shaped displacement along the inside of the arc-shaped frame 722. This design can provide a stable and adjustable arc-shaped motion trajectory for the part connected to the angle adjustment component 73, thereby better simulating the arc-shaped motion that may occur in the limbs of mice in a natural state, which helps to construct a more realistic intervertebral disc degeneration model.

[0058] This arc displacement design not only improves the accuracy and reliability of the experiment, but also enables experimenters to flexibly adjust the position and movement trajectory of the mouse's limbs according to different experimental needs, providing a powerful tool for in-depth research on the pathological process of intervertebral disc degeneration. At the same time, the precise mechanical structure design also ensures the durability and stability of the device, and can maintain good performance during long-term experiments.

[0059] The angle adjustment assembly 73 includes a connecting block 731 and a first hinge seat 732, the connecting block 731 is fixedly connected to the middle of the top of the base plate 7241, the first hinge seat 732 is fixedly connected to the outer end of the bottom of the base plate 7241, the top of the connecting block 731 is hinged with a second hinge seat 733, the top of the second hinge seat 733 is connected to the bottom of the linear displacement assembly 74, the base plate 7241 is hinged with a first electric push rod 734 through the first hinge seat 732, the outer end of the first electric push rod 734 is hinged with a third hinge seat 735, the top of the third hinge seat 735 is connected to the outer end of the bottom of the linear displacement assembly 74, the linear displacement assembly 74 includes a side rail 741, the end of the bottom of the side rail 741 close to the ring seat 4 is fixedly connected to the top of the second hinge seat 733, the end of the bottom of the side rail 741 away from the ring seat 4 is connected to the top of the third hinge seat 735, the outer end of the side rail 741 is fixedly connected to the second Motor 742, the output end of the second motor 742 passes through the side rail 741 and is fixedly connected to a one-way screw rod 743, the one-way screw rod 743 is rotatably connected to the inside of the side rail 741, the outer surface of the one-way screw rod 743 is threadedly connected to a sliding block 744, the outer side of the sliding block 744 is fixedly connected to a connecting arm 745, the end of the connecting arm 745 away from the second motor 742 is connected to the positioning component 75, in the angle adjustment component 73, the connecting block 731 is fixed in the middle of the top of the base plate 7241, providing a stable connection point for the second articulated seat 733, the first articulated seat 732 and the third articulated seat 735 are respectively connected to the base plate 7241 and the outer end of the bottom of the linear displacement component 74, and cooperate with the first electric push rod 734 to realize flexible adjustment of the angle of the linear displacement component 74. This design can accurately adjust the angle of the mouse's limbs according to experimental requirements, better simulate the body posture under different conditions, and help to more comprehensively study the pathological process of intervertebral disc degeneration.

[0060] The side rail 741 of the linear displacement assembly 74 is connected to the angle adjustment assembly 73 through the second hinge seat 733 and the third hinge seat 735, ensuring the stability of the overall structure. The second motor 742 at the outer end of the side rail 741 drives the one-way screw 743 to rotate, so that the threaded sliding block 744 can move accurately inside the side rail 741. The connecting arm 745 on the outer side of the sliding block 744 is connected to the positioning assembly 75, thereby realizing linear adjustment of the position of the mouse's limbs. This linear displacement function can accurately control the extension degree and position of the mouse's limbs, providing more accurate data support for the experiment.

[0061] In general, the synergistic effect of the angle adjustment component 73 and the linear displacement component 74 enables the device to perform multi-angle and multi-directional precise adjustments to the mouse limbs, thereby improving the flexibility and accuracy of the experiment and providing a powerful tool for in-depth research on intervertebral disc degeneration. At the same time, the precise mechanical structure design ensures the reliability and durability of the device, and can maintain good performance during long-term experiments.

[0062] The positioning component 75 includes a rotating shaft 751, which is rotatably connected to the inner end of the connecting arm 745 away from the second motor 742. A positioning frame 752 is fixedly connected between the inner sides of the rotating shaft 751. The top of the positioning frame 752 is threadedly connected with a hand-tightened screw 753. The end of the hand-tightened screw 753 passes through the positioning frame and is rotatably connected with a splint 754. The rotating shaft 751 in the positioning component 75 is connected to the inner end of the connecting arm 745 away from the second motor 742, so that the positioning frame 752 can rotate flexibly. This design is of great significance in practical applications. When the position and angle of the mouse limbs need to be adjusted, the positioning frame 752 can rotate adaptively to avoid unnecessary distortion and damage to the mouse limbs.

[0063] The positioning frame 752 is a key part for fixing the mouse's limbs. Its structural design is reasonable. The hand-tightening screw 753 on the top is easy to operate. By rotating the hand-tightening screw 753, the splint 754 at the end can move up and down in the positioning frame 752. When fixing the mouse's limbs, the operator can easily adjust the position of the splint 754 according to the size and shape of the mouse's limbs to ensure that the mouse's limbs are firmly fixed in the positioning frame 752, preventing the limbs from shifting during the experiment, thereby ensuring the accuracy and reliability of the experiment.

[0064] In addition, the design of this positioning component 75 is simple and practical. It is not only easy to operate, but also can adapt to mice of different sizes, which improves the versatility of the device. In the experiment of constructing an intervertebral disc degeneration model, the stable and reliable positioning component 75 provides a strong guarantee for the smooth progress of the experiment, which helps scientific researchers to more accurately study the pathological mechanism of intervertebral disc degeneration.

[0065] like Figures 1 to 6As shown, the body clamping mechanism 5 includes a mounting base 51, the mounting base 51 is fixedly connected to the bottom of the ring seat 4, the inner middle part of the mounting base 51 is fixedly connected to the second electric push rod 52, the top of the second electric push rod 52 is fixedly connected to the clamping assembly 53, the clamping assembly 53 includes a receiving plate 531, the receiving plate 531 is fixedly connected to the top of the second electric push rod 52, the middle part of the receiving plate 531 is fixedly connected to a guide rail 532, one end of the guide rail 532 is fixedly connected to a third motor 533, the output end of the third motor 533 passes through the guide rail 532 and is fixedly connected to a bidirectional screw rod 534, the two ends of the bidirectional screw rod 534 have opposite thread rotation directions, the bidirectional screw rod 534 is rotatably connected to the inside of the guide rail 532, and the two ends of the bidirectional screw rod 534 are threadedly connected to the displacement block 5 35. The top of the displacement block 535 is fixedly connected with a clamping arm 536, and the outer end side surface of the clamping arm 536 is semi-arc-shaped. The positioning assembly 75 also includes a support rod 755, and the support rod 755 is fixedly connected to the top two sides of the splint 754. The top of the support rod 755 passes through the positioning frame 752. The bottom of the splint 754 and the inner bottom of the positioning frame 752 are both fixedly connected with a toothed anti-slip plate 756, and the toothed anti-slip plate 756 is made of silicone material. The mounting base 51 is fixed to the inner bottom of the ring seat 4 to provide a stable support for the entire body clamping mechanism 5. The second electric push rod 52 in the middle of the inner side of the mounting base 51 can accurately control the height of the clamping assembly 53 to achieve the expansion or bending adjustment of the mouse body, which is helpful to simulate different body states and better study the pathological process of intervertebral disc degeneration.

[0066] The receiving plate 531 in the clamping assembly 53 is connected to the top of the second electric push rod 52 to provide an installation position for the guide rail 532. The third motor 533 drives the bidirectional screw 534 to rotate. Since the threads at both ends of the screw have opposite rotation directions, the displacement blocks 535 at both ends can slide back and forth in the guide rail 532, thereby driving the clamping arm 536 to achieve precise clamping of the mouse body. The outer end side of the clamping arm 536 is semi-arc-shaped, which better fits the shape of the mouse body and can provide a more stable clamping effect.

[0067] The support rod 755 in the positioning component 75 provides support and guidance for the movement of the splint 754, ensuring that the splint 754 can move down stably. The splint 754 and the toothed anti-skid plate 756 at the bottom of the positioning frame 752 are made of silicone material. On the one hand, the silicone material is soft and can avoid causing harm to the mouse when fixing the mouse's limbs. At the same time, it can also provide good friction to ensure that the mouse's limbs are firmly fixed. On the other hand, the toothed design increases the anti-slip effect and further improves the stability of the fixation.

[0068] In general, the body clamping mechanism 5 and the positioning assembly 75 are reasonably designed and practical in function, providing reliable technical support for constructing an intervertebral disc degeneration model using mice for simulation, and improving the accuracy and operability of the experiment.

[0069] The workflow of the technical solution provided by the present invention is as follows:

[0070] First, place the body of the experimental animal steadily on the top of the receiving plate 531, and start the third motor 533. The third motor 533 can effectively drive the bidirectional screw 534 to rotate. During the rotation of the bidirectional screw 534, it can assist in driving the displacement block 535 to slide smoothly inside the guide rail 532. It is worth noting that the threads at both ends of the screw have opposite rotation directions. This design makes it possible to assist in driving the displacement blocks 535 at both ends of the screw to slide back and forth inside the guide rail 532 when the bidirectional screw 534 rotates. By accurately adjusting the reciprocating sliding of the displacement block 535, the clamping arm 536 can be assisted in moving back and forth. At this time, by adjusting The reciprocating movement of the clamping arm 536 can assist in accurately positioning and clamping the animal body placed on the top of the receiving plate 531. During use, the second electric push rod 52 can be started to operate. When the second electric push rod 52 is extended, it can push the receiving plate 531 upward. The upward movement of the receiving plate 531 can push the animal body into an expanded state; and when the second electric push rod 52 is contracted, it can pull the animal body downward, at which time the animal body can be placed in a bent state. When used as a whole, in conjunction with the limb positioning mechanism 7, the limbs and lumbar vertebrae of the experimental animal can be flexibly adjusted and swung, greatly improving the adaptability of the device required in experimental exploration during overall use.

[0071] By setting up the limb positioning mechanism 7, the limbs of the experimental animal can be respectively filled into the interior of the positioning frame 752, and by twisting the hand-tightening screw 753, the splint 754 can be driven to move downward, and the support rod 755 can assist in supporting and guiding, so that the splint 754 can move downward stably; at this time, the two toothed anti-skid plates 756 are close to each other, and then the animal limbs filled into the interior of the positioning frame 752 can be firmly fixed. Since the toothed anti-skid plates 756 are made of silicone material, they are relatively soft, and at this time, the limbs of the animal can be stably clamped and positioned. After the limbs of the animal are positioned, the second motor 742 can be started to drive the unidirectional wire The rod 743 rotates, and the one-way screw rod 743 rotates to drive the sliding block 744 to slide on the inner side of the side rail 741. The sliding of the sliding block 744 can drive the connecting arm 745 to move. The movement of the connecting arm 745 can pull and drive the positioning frame 752 to move. By adjusting the displacement of the positioning frame 752, it can flexibly adapt to animals of different sizes, which greatly improves the adaptability of the device during the overall use period. In addition, during the adjustment period, since the rotating shaft 751 is set, the positioning frame 752 can rotate adaptively during the adjustment process to avoid fractures of the animal's limbs, thereby better protecting the experimental animals.

[0072] By setting the angle adjustment component 73 and the arc displacement component 72, when the animal's limbs are fixed, the first motor 7244 can be started to run, and the operation of the first motor 7244 can drive the gear 7245 to rotate, and the gear 7245 and the arc rack 7242 are meshed and connected, and the arc slider 723 can be driven to slide inside the arc frame 722 through the rotation of the gear 7245. At this time, the arc slider 723 slides along the arc cavity of the arc frame 722, and then the positioning frame 752 can be driven to perform an arc displacement, which can assist in flexibly adjusting the reciprocating lateral swing of the animal's limbs. During the swinging period, the first electric push rod 734 can be operated, and the operation of the first electric push rod 734 can assist in pushing the side rail 7 41 rotational displacement, at this time, the first hinge seat 732, the second hinge seat 733, the third hinge seat 735 and the connecting block 731 are rotated in conjunction, and then the side rail 741 can be flexibly adjusted to drive the rotation. By adjusting the rotation of the side rail 741, the side rail 741 that drives the linear displacement component 74 can be adjusted to adjust the angle. The angle of the linear displacement component 74 is adjusted, and the stroke of the linear displacement component 74 can be changed. At this time, the up and down activities of the animal's limbs can be adjusted, which can further improve the convenience of the overall use of the device, and enable the animal's limbs to flexibly swing and displace in any direction as a whole after positioning is completed, which can greatly improve the overall adjustment and adaptation performance of the device during lumbar pathology research.

[0073] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0074] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A device for constructing an intervertebral disc degeneration model using mice, characterized in that: include: A base plate is installed, a support rod is connected to the middle of the top of the base plate, a top seat is fixedly connected to the top of the support rod, a ring seat is fixedly connected to the inner side of the top seat, a body clamping mechanism is fixedly connected to the inner side of the ring seat, a fixing frame is fixedly connected to the outer side of the ring seat in a ring shape at equal intervals, and a limb positioning mechanism is fixedly connected to the top of each fixing frame; The limb positioning mechanism includes a fixing plate, which is mounted on the top outer end of the fixing frame by screws, the top of the fixing plate is fixedly connected to an arc displacement component, the top of the arc displacement component is fixedly connected to an angle adjustment component, the top of the angle adjustment component is fixedly connected to a linear displacement component, and the inner end of the linear displacement component is fixedly connected to a positioning component.

2. The device for simulating intervertebral disc degeneration model using mice according to claim 1, characterized in that: Both sides of the top of the mounting base plate are provided with mounting holes, and the mounting holes are all configured as countersunk holes. The outer corners of the mounting base plate, the top seat and the ring seat are all configured as arcs.

3. The device for constructing an intervertebral disc degeneration model using mice according to claim 1, characterized in that: The arc displacement assembly includes a support leg, which is fixedly connected to the top of a fixed plate, and an arc frame is fixedly connected to the top of the support leg, and an arc slider is slidably connected inside the arc frame, and a driving group is fixedly connected to one side of the arc slider, the driving group is connected to the arc frame, and one side of the driving group is connected to the bottom of the angle adjustment assembly.

4. The device for constructing an intervertebral disc degeneration model using mice according to claim 3, characterized in that: The driving group includes a base plate and an arc-shaped rack, the base plate is fixedly connected to the top of the arc-shaped slider, a side of the base plate close to the ring seat is fixedly connected to a mounting arm, the bottom of the mounting arm is fixedly connected to a first motor, an output end of the first motor passes through the fixed arm and is fixedly connected to a gear, the arc-shaped rack is fixedly connected to a side of the arc frame close to the ring seat, the gear and the arc-shaped rack are meshed and connected, and one side of the base plate is connected to an angle adjustment component.

5. The device for constructing an intervertebral disc degeneration model using mice according to claim 4, characterized in that: The angle adjustment assembly includes a connecting block and a first articulated seat, the connecting block is fixedly connected to the top middle of the base plate, the first articulated seat is fixedly connected to the bottom outer end of the base plate, the top of the connecting block is hinged with a second articulated seat, the top of the second articulated seat is connected to the bottom of the linear displacement assembly, the base plate is hinged with a first electric push rod through the first articulated seat, the outer end of the first electric push rod is hinged with a third articulated seat, the top of the third articulated seat is connected to the bottom outer end of the linear displacement assembly.

6. The device for constructing an intervertebral disc degeneration model using mice according to claim 5, characterized in that: The linear displacement assembly includes a side rail, wherein one end of the bottom of the side rail close to the ring seat is fixedly connected to the top of the second hinge seat, and one end of the bottom of the side rail away from the ring seat is connected to the top of the third hinge seat. The outer end of the side rail is fixedly connected to the second motor, and the output end of the second motor passes through the side rail and is fixedly connected to a one-way screw rod, which is rotatably connected to the inside of the side rail. The outer surface of the one-way screw rod is threadedly connected to a sliding block, and the outer side of the sliding block is fixedly connected to a connecting arm, and the end of the connecting arm away from the second motor is connected to the positioning assembly.

7. The device for constructing an intervertebral disc degeneration model using mice according to claim 6, characterized in that: The positioning assembly includes a rotating shaft, which is rotatably connected to the inner end of the connecting arm away from the second motor. A positioning frame is fixedly connected between the inner sides of the rotating shaft. A hand-tightening screw is threadedly connected to the top of the positioning frame. The end of the hand-tightening screw passes through the positioning frame and is rotatably connected to a splint.

8. The device for constructing an intervertebral disc degeneration model using mice according to claim 1, characterized in that: The body clamping mechanism comprises a mounting base, the mounting base is fixedly connected to the inner bottom of the ring seat, a second electric push rod is fixedly connected to the inner middle of the mounting base, and a clamping assembly is fixedly connected to the top of the second electric push rod.

9. The device for constructing an intervertebral disc degeneration model using mice according to claim 8, characterized in that: The clamping assembly includes a socket plate, which is fixedly connected to the top of the second electric push rod, a guide rail is fixedly connected to the middle of the socket plate, one end of the guide rail is fixedly connected to a third motor, an output end of the third motor passes through the guide rail and is fixedly connected to a bidirectional screw rod, the threads at both ends of the bidirectional screw rod have opposite rotation directions, the bidirectional screw rod is rotatably connected to the inside of the guide rail, both ends of the bidirectional screw rod are threadedly connected to displacement blocks, the top of the displacement block is fixedly connected to a clamping arm, and the outer end side surface of the clamping arm is semi-arc-shaped.

10. The device for constructing an intervertebral disc degeneration model using mice according to claim 7, characterized in that: The positioning assembly also includes a support rod, which is fixedly connected to both sides of the top of the splint. The top of the support rod passes through the positioning frame. The bottom of the splint and the bottom of the positioning frame are both fixedly connected with a toothed anti-skid plate, and the toothed anti-skid plate is made of silicone material.

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