Ophthalmic operation platform for rodents

Abstract

The invention discloses a rodent ophthalmologic operation platform, and relates to the technical field of operation platforms, the rodent ophthalmologic operation platform comprises a bottom table, an operation plate and a heating plate, the bottom table is in a flat cuboid shape, two air inflation bags are symmetrically installed on the side wall of a second groove, and the air inflation bags are arranged in the bottom table. The inflatable bag body is in a long strip shape and is connected to the micro air pump through a hose, the micro air pump works to enable the inflatable bag body to expand and clamp the head of the rodent, the pressure in the inflatable bag body can be fed back in real time by installing an air pressure sensor, the pressure in the inflatable bag body is controlled to be 5-15 kPa, and on the premise that the fixing effect is kept, the safety of the rodent is improved. Rodents are prevented from being hurt, rapid exhaust can be carried out in emergency, and the safety of the rodents is guaranteed.

Description

Technical Field

[0001] The present invention relates to the technical field of surgical platforms, and in particular to an ophthalmic surgical platform for rodents. Background Art

[0002] Rodents are the most commonly used subjects for experimental research in the scientific community, including the medical and biological communities. In the United States, up to 95% of animal research is conducted on rodents. Because they are also mammals, small, easy to breed, and cheap, the use of laboratory rats or mice in ophthalmic research has also increased exponentially. At present, there is no dedicated platform for rodent ophthalmic surgery in the world. Due to the special body shape of rodents, such as large bodies, small pointed heads, and eyes on both sides of the face, how to quickly, conveniently and smoothly complete rodent ophthalmic surgery is also an urgent problem to be solved. During the rodent ophthalmic surgery platform operation, the surgeon usually removes the experimental animal first, anesthetizes it, and then performs dissection or other surgical operations; during ophthalmic surgery, the experimental animal must be required to lie on its side to ensure the stability of the head of the experimental animal; during or after the operation, the body temperature of the experimental animal needs to be maintained constant to improve its postoperative survival rate; in addition, after the operation, the platform needs to be cleaned.

[0003] The Chinese invention patent with publication number CN111249099A in the prior art discloses a rodent ophthalmic surgery platform, which includes: a load-bearing portion, which is flat; a main body portion, which is fixed on the load-bearing portion, the main body portion having a first recess for accommodating the body of a rodent and a preparation table close to the first recess and for placing the rodent, the first recess having a shape matching the body of the rodent, and a gap formed between the main body portion and the surface of the load-bearing portion; an auxiliary portion, which is arranged on the load-bearing portion and cooperates with the main body portion, the auxiliary portion having a base, the base having a second recess cooperating with the first recess of the main body portion and for accommodating the body of the rodent, the width of the second recess gradually decreasing in a direction away from the main body portion to form a shape matching the body of the rodent, the base having a first groove for accommodating the head of the rodent; and a heating plate, which is detachably mounted in the gap and used for heating to a predetermined temperature, the heating plate having a handle for lifting.

[0004] However, since the above-mentioned device only serves to support the rodents when in use, and since rodents are usually anesthetized or locally anesthetized during surgery, and rodents have small heads, it may not be possible to effectively limit the shaking of their heads by simply supporting them, thereby increasing the difficulty of the surgery. Summary of the invention

[0005] The embodiments of the present application solve the technical problems in the above-mentioned prior art by providing a rodent ophthalmic surgery platform.

[0006] The present application provides a rodent ophthalmic surgery platform, including a base, a surgical plate and a heating plate, wherein the base is in a flat rectangular shape, the surgical plate is composed of a rectangular plate and a semicircular plate, the surgical plate is mounted on the base, a receiving groove is provided at the bottom of the surgical plate, the heating plate is installed in the receiving groove, a first groove for accommodating rodents is provided at the top of the surgical plate, the first groove is elliptical, a second groove for accommodating the head of the rodent is provided on the semicircular part of the surgical plate, and two symmetrically mounted on the side walls of the second groove The inflatable bladder is in the shape of an elongated strip and is connected to a micro air pump through a hose. An auxiliary bladder is sleeved and installed on the surface of each inflatable bladder. A filling layer is formed between the inner wall of the auxiliary bladder and the outer wall of the inflatable bladder, and paraffin is filled in the filling layer. A heating component capable of heating the second groove is installed in the second groove. After the paraffin is softened by heating, the micro air pump can control the inflatable bladder and the auxiliary bladder to expand, fix and fit the rodent's head together through inflation. The paraffin is then cooled to set and increase the rigidity of fixing the rodent's head.

[0007] Furthermore, two separation films are installed in the filling layer, and the two separation films separate the filling layer into response layer one, response layer two and response layer three. The response layer one, response layer two and response layer three are isolated from each other, and among the response layer one, response layer two and response layer three, response layer one is farthest from the inflatable bladder and is the outermost layer; response layer three is closest to the inflatable bladder and is the innermost layer; response layer two is located between response layer one and response layer three and is the middle layer; and the response layer one, response layer two and response layer three are all filled with paraffin.

[0008] Furthermore, the response layer one is filled with low-melting point paraffin, and its phase change temperature is 32 degrees Celsius; the response layer two is filled with medium-melting point paraffin, and its phase change temperature is 35 degrees Celsius; the response layer three is filled with high-melting point paraffin, and its phase change temperature is 38 degrees Celsius; when the heating component performs gradient heating, the paraffin in the response layer one, the response layer two and the response layer three can be controlled to soften gradually.

[0009] Furthermore, a plurality of honeycomb cavities are installed in the response layer 1, the response layer 2 and the response layer 3, the honeycomb cavities are made of elastic material, and the paraffin filled in the response layer 1, the response layer 2 and the response layer 3 are all located in the honeycomb cavities.

[0010] Furthermore, the aperture of the honeycomb cavity in the response layer three is larger than the aperture of the honeycomb cavity in the response layer two, and the aperture of the honeycomb cavity in the response layer two is larger than the aperture of the honeycomb cavity in the response layer one.

[0011] Furthermore, the diameter of the honeycomb cavity in the response layer three is 5 mm, and the wall thickness is 0.3 mm; the diameter of the honeycomb cavity in the response layer two is 3 mm, and the wall thickness is 0.2 mm; the diameter of the honeycomb cavity in the response layer one is 1.5 mm, and the wall thickness is 0.1 mm.

[0012] Furthermore, a third groove is provided on the surgical plate, the third groove is in a rectangular shape, and a first notch is provided between the third groove and the first groove to connect the two.

[0013] One or more technical solutions provided in the embodiments of the present application have at least the following technical effects or advantages:

[0014] First, the present invention can automatically fill the gap according to the head size of the rodent (such as mice and rats) after the inflatable bag is inflated, avoiding loosening or compression caused by size mismatch of the traditional fixing clamp; and can ensure that the clamping force is always within the safety threshold, preventing blood vessel compression or tissue damage caused by muscle relaxation after anesthesia; compared with the manual adjustment clamp, the inflation system simplifies the operation process, shortens the preoperative preparation time, and speeds up the efficiency of turning the rodent over during the operation; in emergency situations (such as the rodent waking up and struggling), it can quickly exhaust gas to ensure the safety of the animal;

[0015] Secondly, the present invention softens the paraffin by heating, and then inflates the auxiliary capsule to fit the rodent's head, and then obtains a rigid fixing force after cooling, which can not only avoid the displacement of the rodent's head caused by an emergency, but also resist the external force interference of the instrument operation during the operation, thereby ensuring the surgical effect; and after the phase change material is solidified, it completely fits the anatomical features of the animal's head (such as the bulge of the rat's skull), reduces local pressure concentration, and improves the postoperative survival rate of the rodent while maintaining the fixing effect;

[0016] Third, the present invention performs inflation and heating simultaneously. In the low temperature stage (32°C), the response layer 1 is softened first to achieve initial gentle fitting. As the temperature rises, the response layer 2 and the response layer 3 are activated in sequence to gradually enhance the fixing force. This avoids direct contact with animal tissue at a high temperature (38°C) at one time, and the gradient temperature rise reduces heat stress. The multi-layer paraffin bears external forces in stages, and the fatigue resistance is improved compared to the single-layer structure. When a single-layer paraffin leaks, the remaining layers can still maintain their functions, thereby improving the system's fault tolerance. Moreover, the capsule hardness can be switched by controlling the temperature (e.g., full flexibility at 38°C → semi-flexibility at 35°C), which can adapt to the requirements of different surgical steps (e.g., high rigidity is required for incision, and moderate buffering is required for suturing), thereby improving the comfort of surgery.

[0017] Fourthly, the present invention shortens the heat conduction path through the small honeycomb units in the response layer 1, the low-temperature paraffin is quickly softened, and the large honeycomb cavity in the response layer 3 stores more paraffin, prolongs the duration of the high-temperature phase change, and reduces the need for repeated heating during surgery; the regular hexagonal honeycomb cavity disperses external forces (such as the impact when the animal struggles) and improves the compressive strength; the small honeycombs in the low-temperature layer provide rapid deformation, and the large honeycombs in the high-temperature layer ensure the ultimate rigidity and avoid local stress concentration; the thin walls of the honeycomb cavity still retain a slight elasticity after the paraffin solidifies, reducing the pressure on the animal's epidermis, not only achieving rapid response and precise fitting, but also extending the service life of each component in the filling layer and improving surgical comfort. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0019] Figure 2 It is an exploded view of the three-dimensional structure of the present invention;

[0020] Figure 3 It is a schematic diagram of the expansion state of the inflatable bladder in the present invention;

[0021] Figure 4 is a cross-sectional view of the auxiliary capsule in the second embodiment of the present invention;

[0022] Figure 5 is a cross-sectional view of the auxiliary capsule in the third embodiment of the present invention;

[0023] Figure 6 It is a schematic diagram of the three-dimensional structure of the honeycomb cavity in the fourth embodiment of the present invention;

[0024] Figure 7 Schematic diagram of the honeycomb cavities in response layer one, response layer two and response layer three in embodiment four of the present invention.

[0025] In the figure: 100, base; 110, surgical board; 111, receiving groove; 112, first groove; 113, second groove; 114, third groove; 115, first notch; 120, heating plate; 200, inflatable bladder; 210, auxiliary bladder; 220, filling layer; 230, separation film; 240, response layer one; 250, response layer two; 260, response layer three; 270, honeycomb cavity. DETAILED DESCRIPTION

[0026] To facilitate the understanding of the present invention, the present application will be described more comprehensively below with reference to the relevant drawings; the drawings show preferred embodiments of the present invention, but the present invention can be implemented in many different forms and is not limited to the embodiments described herein; on the contrary, the purpose of providing these embodiments is to enable a more thorough and comprehensive understanding of the disclosed content of the present invention.

[0027] It should be noted that the terms “vertical”, “horizontal”, “up”, “down”, “left”, “right” and similar expressions used in this document are only for illustrative purposes and do not represent the only implementation method.

[0028] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by technicians in the technical field to which the present invention belongs; the terms used in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention; the term "and / or" used herein includes any and all combinations of one or more related listed items.

[0029] Embodiment 1, as Figure 1-Figure 3 As shown, the embodiment of the present application provides a rodent ophthalmic surgery platform, including a base 100, a surgical plate 110 and a heating plate 120, wherein the base 100 is in a flat rectangular shape, the surgical plate 110 is composed of a rectangular plate and a semicircular plate, the surgical plate 110 is installed on the base 100, a receiving groove 111 is provided at the bottom of the surgical plate 110, and the heating plate 120 is installed in the receiving groove 111, and the surgical plate 110 can be heated by the operation of the heating plate 120 to maintain the optimal temperature during surgery on rodents, so as to improve the postoperative survival rate, a first groove 112 for accommodating rodents is provided on the top of the surgical plate 110, and the first groove 112 is elliptical, and a second groove 113 for accommodating the head of the rodent is provided on the semicircular part of the surgical plate 110, and two inflatable bladders 200 are symmetrically installed on the side walls of the second groove 113, and the inflatable bladders 200 are in the shape of elongated strips, and the inflatable bladders 200 The micro air pump 200 is connected to the micro air pump (not shown in the figure) through a hose. The micro air pump can inflate the inflatable bag 200 and clamp the head of the rodent. The pressure in the inflatable bag 200 can be fed back in real time by installing an air pressure sensor, so that the pressure in the inflatable bag 200 is controlled at 5-15 kPa. Under the premise of maintaining the fixation effect, the rodent is avoided from being hurt. Because the eyes of the rodent are located on both sides of its head, when performing eye surgery on the rodent, the rodent is usually laid on its side on the surgical board 110, and the surgery is first performed on one eye. After the surgery, the rodent is turned over and the other eye is operated on. The head of the rodent is fixed by the inflatable bag 200. Not only is the fixation gentler and less likely to cause damage to the rodent, but also when the rodent is turned over, the response of releasing the fixation by the expansion-contraction of the inflatable bag 200 is faster, which is convenient for turning the rodent over.

[0030] Preferably, a third groove 114 is provided on the surgical plate 110, and the third groove 114 is used to place rodents during preoperative preparation. The third groove 114 is rectangular, and a first groove 115 is provided between the third groove 114 and the first groove 112 to connect the two, and the first groove 115 can accommodate the tail of the rodent.

[0031] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0032] After the inflatable bag 200 is inflated, the gap can be automatically filled according to the head size of the rodent (such as mice and rats), avoiding loosening or compression caused by size mismatch of traditional fixing clamps: and it can ensure that the clamping force is always within the safety threshold to prevent blood vessel compression or tissue damage caused by muscle relaxation after anesthesia; compared with the manually adjusted clamp, the inflation system simplifies the operating process, shortens the preoperative preparation time, and speeds up the efficiency of turning the rodent over during surgery; in emergency situations (such as the rodent waking up and struggling), it can quickly exhaust air to ensure the safety of the animal.

[0033] Embodiment 2: Since the first embodiment implements the clamping and fixing of the rodent by inflating the inflatable bladder 200, the fixing force is flexible. When encountering some unexpected situations (such as when the rodent convulses), it may cause its head to shift, affecting the surgical effect. In order to solve this problem, Figure 4 As shown, further improvements are made to the first embodiment:

[0034] An auxiliary bladder 210 is installed on the surface of each inflatable bladder 200, and a filling layer 220 is formed between the inner wall of the auxiliary bladder 210 and the outer wall of the inflatable bladder 200, and paraffin is filled in the filling layer 220. A heating component (not shown in the figure) capable of heating the second groove 113 is installed in the second groove 113. The heating component is an electric heating wire. After heating and softening the paraffin, the micro air pump can control the inflatable bladder 200 and the auxiliary bladder 210 to expand, fix and fit the rodent's head together, and then cool down to allow the paraffin to be shaped to increase the fixing rigidity of the rodent's head.

[0035] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0036] The paraffin is softened by heating, and then inflated to make the auxiliary capsule 210 fit the rodent's head, and then cooled to obtain a rigid fixing force, which can not only avoid the displacement of the rodent's head due to sudden situations, but also resist the external force interference of instrument operation during surgery, thereby ensuring the surgical effect; and after the phase change material is solidified, it completely fits the anatomical features of the animal's head (such as the bulge of the rat's skull), reduces local pressure concentration, and improves the postoperative survival rate of the rodent while maintaining the fixation effect.

[0037] Embodiment 3: In order to further enhance the fixation effect on the rodent's head, Figure 5 As shown, further improvements are made to the second embodiment:

[0038] Preferably, two separation films 230 are also installed in the filling layer 220, and the two separation films 230 separate the filling layer 220 into response layer one 240, response layer two 250 and response layer three 260. The response layer one 240, response layer two 250 and response layer three 260 are isolated from each other, and among the response layer one 240, response layer two 250 and response layer three 260, response layer one 240 is farthest from the inflatable bladder 200 and is the outermost layer; response layer three 260 is closest to the inflatable bladder 200 and is the innermost layer; response layer two 250 is located between response layer one 240 and response layer three 260 and is the middle layer; and the response layer one 240, response layer two 250 and response layer three 260 are all filled with paraffin.

[0039] Preferably, the response layer 1 240 is filled with low melting point paraffin, whose phase change temperature is 32 degrees Celsius; the response layer 250 is filled with medium melting point paraffin, whose phase change temperature is 35 degrees Celsius; the response layer 3 260 is filled with high melting point paraffin, whose phase change temperature is 38 degrees Celsius; when the heating component performs gradient heating, the paraffin in the response layer 1 240, the response layer 2 250 and the response layer 3 260 can be controlled to soften gradually.

[0040] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0041] Through the simultaneous inflation and heating, the response layer 1 240 is softened first at the low temperature stage of 32°C to achieve an initial gentle fit; as the temperature rises, the response layer 250 and the response layer 3 260 are activated in sequence to gradually enhance the fixing force; this avoids direct contact with animal tissue at a high temperature of 38°C at one time, and the gradient temperature increase reduces heat stress; the multiple layers of paraffin withstand external forces in stages, and compared with the single-layer structure, the fatigue resistance is improved; when a single-layer paraffin leaks, the remaining layers can still maintain their functions, improving the system's fault tolerance; and the capsule hardness can be switched by controlling the temperature (such as 38°C full flexibility → 35°C semi-flexibility) to adapt to the requirements of different surgical steps (such as high rigidity during incision and moderate buffering during suturing), thereby improving surgical comfort.

[0042] Embodiment 4: In order to enhance the service life of the response layer 1 240, the response layer 2 250 and the response layer 3 260, as shown in FIG. Figure 6-Figure 7 As shown, further improvements are made to the third embodiment:

[0043] Preferably, a plurality of honeycomb cavities 270 are installed in the response layer 1 240 , the response layer 2 250 and the response layer 3 260 , the honeycomb cavities 270 are made of elastic material, and the paraffin filled in the response layer 1 240 , the response layer 2 250 and the response layer 3 260 are all located in the honeycomb cavities 270 .

[0044] Preferably, the aperture of the honeycomb cavity 270 in the response layer three 260 is larger than that of the honeycomb cavity 270 in the response layer two 250 , and the aperture of the honeycomb cavity 270 in the response layer two 250 is larger than that of the honeycomb cavity 270 in the response layer one 240 .

[0045] Preferably, the diameter of the honeycomb cavity 270 in the response layer three 260 is 5 mm, and the wall thickness is 0.3 mm; the diameter of the honeycomb cavity 270 in the response layer two 250 is 3 mm, and the wall thickness is 0.2 mm; the diameter of the honeycomb cavity 270 in the response layer one 240 is 1.5 mm, and the wall thickness is 0.1 mm.

[0046] When fixing, the micro air pump inflates and heats the heating component.

[0047] Response layer 1 240 priority response: The small aperture honeycomb quickly heats up to 32°C, and the paraffin softens and fits the contour of the head.

[0048] Responsive layer two 250 enhanced support: medium-aperture honeycomb heated to 35°C to fill the tiny gaps after initial bonding.

[0049] Response layer three 260 Final response: The large aperture honeycomb is heated to 38°C to form an overall support.

[0050] The technical solutions in the above embodiments of the present application have at least the following technical effects or advantages:

[0051] The small honeycomb units in the response layer 1 240 shorten the heat conduction path, the low-temperature paraffin softens quickly, and the large honeycomb cavity in the response layer 3 260 stores more paraffin, prolongs the duration of the high-temperature phase change, and reduces the need for repeated heating during surgery; the regular hexagonal honeycomb cavity 270 disperses external forces (such as the impact when the animal struggles) and improves the compressive strength; the small honeycombs in the low-temperature layer provide rapid deformation, and the large honeycombs in the high-temperature layer ensure the ultimate rigidity and avoid local stress concentration; the thin walls of the honeycomb cavity 270 still retain a slight elasticity after the paraffin solidifies, reducing the pressure on the animal's epidermis, not only achieving rapid response and precise fitting, but also extending the service life of each component in the filling layer 220 and improving surgical comfort.

[0052] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A rodent ophthalmic surgery platform, comprising a base (100), a surgical plate (110) and a heating plate (120), wherein the base (100) is in the shape of a flat rectangular parallelepiped, the surgical plate (110) is composed of a rectangular parallelepiped plate and a semicircular plate, the surgical plate (110) is mounted on the base (100), a receiving groove (111) is provided at the bottom of the surgical plate (110), the heating plate (120) is installed in the receiving groove (111), a first groove (112) for receiving a rodent is provided at the top of the surgical plate (110), the first groove (112) is elliptical, a second groove (113) for receiving a rodent's head is provided on the semicircular portion of the surgical plate (110), and the characteristics are as follows: Two inflatable bladders (200) are symmetrically mounted on the side wall of the second groove (113). The inflatable bladders (200) are in the shape of long strips. The inflatable bladders (200) are connected to a micro air pump via a hose. An auxiliary bladder (210) is sleeved and mounted on the surface of each inflatable bladder (200). A filling layer (220) is formed between the inner wall of the auxiliary bladder (210) and the outer wall of the inflatable bladder (200), and paraffin is filled in the filling layer (220). A heating component capable of heating the second groove (113) is mounted in the second groove (113). After the paraffin is softened by heating, the micro air pump can inflate the inflatable bladder (200) and the auxiliary bladder (210) to expand, fix and fit the rodent's head together. After cooling, the paraffin is shaped to increase the rigidity of fixing the rodent's head.

2. A rodent ophthalmic surgery platform according to claim 1, characterized in that: Two separation films (230) are also installed in the filling layer (220), and the two separation films (230) separate the filling layer (220) into a response layer one (240), a response layer two (250) and a response layer three (260). The response layer one (240), the response layer two (250) and the response layer three (260) are isolated from each other, and among the response layer one (240), the response layer two (250) and the response layer three (260), the response layer one (240) is farthest from the inflatable bladder (200) and is the outermost layer; the response layer three (260) is closest to the inflatable bladder (200) and is the innermost layer; the response layer two (250) is located between the response layer one (240) and the response layer three (260) and is the middle layer; and the response layer one (240), the response layer two (250) and the response layer three (260) are all filled with paraffin.

3. A rodent ophthalmic surgery platform according to claim 2, characterized in that: The response layer 1 (240) is filled with low melting point paraffin, and its phase transition temperature is 32 degrees Celsius; the response layer 2 (250) is filled with medium melting point paraffin, and its phase transition temperature is 35 degrees Celsius; the response layer 3 (260) is filled with high melting point paraffin, and its phase transition temperature is 38 degrees Celsius; when the heating component performs gradient heating, the paraffin in the response layer 1 (240), the response layer 2 (250) and the response layer 3 (260) can be controlled to soften gradually.

4. The rodent ophthalmic surgery platform according to claim 2, characterized in that: A plurality of honeycomb cavities (270) are installed in the response layer one (240), the response layer two (250) and the response layer three (260), the honeycomb cavities (270) are made of elastic material, and the paraffin filled in the response layer one (240), the response layer two (250) and the response layer three (260) are all located in the honeycomb cavities (270).

5. The rodent ophthalmic surgery platform according to claim 4, characterized in that: The aperture of the honeycomb cavity (270) in the response layer three (260) is larger than the aperture of the honeycomb cavity (270) in the response layer two (250), and the aperture of the honeycomb cavity (270) in the response layer two (250) is larger than the aperture of the honeycomb cavity (270) in the response layer one (240).

6. The rodent ophthalmic surgery platform according to claim 5, characterized in that: The honeycomb cavity (270) in the response layer three (260) has a diameter of 5 mm and a wall thickness of 0.3 mm; the honeycomb cavity (270) in the response layer two (250) has a diameter of 3 mm and a wall thickness of 0.2 mm; the honeycomb cavity (270) in the response layer one (240) has a diameter of 1.5 mm and a wall thickness of 0.1 mm.

7. The rodent ophthalmic surgery platform according to claim 1, characterized in that: The surgical plate (110) is provided with a third groove (114), which is in a rectangular parallelepiped shape, and a first notch (115) is provided between the third groove (114) and the first groove (112) to connect the two.

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