Superconductive centella asiatica extract as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and discloses a superconductive centella asiatica extract as well as a preparation method and application thereof. The superconductive centella asiatica extract has a core-shell structure, an inner core of the superconductive centella asiatica extract comprises centella asiatica extract, a shell of the superconductive centella asiatica extract comprises ionic liquid, and the ionic liquid comprises ethyoxyl diglycol, urea, betaine, N-ethyl pyrrolidone and hydroxyethyl piperazine ethanesulfonic acid. According to the invention, ethyoxyl diglycol, urea, betaine, N-ethyl pyrrolidone and hydroxyethyl piperazine ethanesulfonic acid are compounded to obtain the ionic liquid, and the centella asiatica extract is wrapped in the ionic liquid, so that the stability, transdermal absorption rate and bioavailability of the centella asiatica extract can be effectively improved.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a superconducting Centella asiatica extract and a preparation method and application thereof. Background Art

[0002] Centella asiatica extract is a type of triterpenoid compound, which has many functions in cosmetics, mainly involving promoting skin regeneration, repairing skin barrier, anti-inflammatory and anti-allergic, moisturizing and anti-inflammatory, anti-oxidation, promoting collagen synthesis, soothing effect and improving skin melanin deposition. Centella asiatica extract can promote the growth and division of skin cells, increase the number of skin cells, thereby improving skin metabolism and promoting skin cell regeneration; Centella asiatica extract can promote the proliferation and differentiation of skin cells, enhance the self-repair ability of skin cells, promote the repair of skin barrier, and improve the barrier function of skin; Centella asiatica extract has high pharmacological activity, can inhibit the production of inflammatory factors, reduce skin inflammation, and has good anti-inflammatory and anti-allergic effects; Centella asiatica extract helps stimulate the synthesis of type I and type III collagen, thereby promoting skin cell renewal and improving skin elasticity.

[0003] However, due to the solubility, skin retention and skin barrier problems of Centella asiatica extract itself, its transdermal absorption rate and bioavailability are low, which also limits the application of Centella asiatica extract in cosmetics. Therefore, how to improve the transdermal absorption rate and bioavailability of Centella asiatica extract is a technical problem to be solved in this field. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the above-mentioned prior art. To this end, the present invention provides a superconducting Centella asiatica extract and a preparation method and application thereof. The superconducting Centella asiatica extract provided by the present invention can effectively improve the stability, transdermal absorption rate and bioavailability of the Centella asiatica extract.

[0005] The first aspect of the present invention provides a superconducting Centella asiatica extract, which has a core-shell structure, wherein the core includes the Centella asiatica extract, and the shell includes an ionic liquid, and the ionic liquid includes ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid.

[0006] Specifically, ethoxydiglycol: as the solvent part of the ionic liquid, it provides good solubility and viscosity characteristics; urea: as a hydrogen bond donor of the ionic liquid, it enhances the stability of the ionic liquid; betaine acts as a hydrogen bond acceptor; N-ethylpyrrolidone: as the cationic part of the ionic liquid, it provides strong polar aprotic solvent properties and enhances the solubility of the ionic liquid; hydroxyethylpiperazineethanesulfonic acid: as the anionic part of the ionic liquid, it provides pH buffering capacity.

[0007] It can be understood that the "superconducting" in the present invention means that the permeability of the Centella asiatica extract coated with the ionic liquid of the present invention is better than that of the conventional Centella asiatica extract.

[0008] In some embodiments of the present invention, the mass ratio of ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid is (4-6):(1-3):(1-3):(1-2):(0.5-1).

[0009] In some embodiments of the present invention, the mass ratio of the Centella asiatica extract to the ionic liquid is 1:(10-100).

[0010] The second aspect of the present invention provides a method for preparing the superconducting Centella asiatica extract according to the first aspect of the present invention, comprising the following steps:

[0011] The ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethanesulfonic acid are mixed and ultrasonicated to obtain an ionic liquid;

[0012] The Centella asiatica extract and the ionic liquid are mixed, heated and stirred, and homogenized under high pressure to obtain a superconducting Centella asiatica extract.

[0013] In some embodiments of the present invention, the power of the ultrasound is 300-500w.

[0014] In some embodiments of the present invention, the ultrasonication time is 0.5 to 2 hours.

[0015] In some embodiments of the present invention, the ultrasound is performed at room temperature, for example, at 20 to 30° C., without heating.

[0016] In some embodiments of the present invention, the temperature of the heating and stirring is 40-70°C.

[0017] In some embodiments of the present invention, the heating and stirring are performed until complete dissolution.

[0018] In some embodiments of the present invention, the pressure of the high-pressure homogenization is 10 to 50 MPa.

[0019] In some embodiments of the present invention, the temperature of the high pressure homogenization is 30-50°C.

[0020] In some embodiments of the present invention, the high pressure homogenization time is 5 to 60 minutes.

[0021] The third aspect of the present invention provides a cosmetic comprising the superconducting Centella asiatica extract according to the first aspect of the present invention.

[0022] In some embodiments of the present invention, the content of the superconducting Centella asiatica extract is 0.01 wt% to 1 wt%.

[0023] In some embodiments of the present invention, the content of the superconducting Centella asiatica extract is 0.01 wt% to 0.2 wt%.

[0024] In some embodiments of the present invention, the dosage form of the cosmetic includes any one of an aqueous solution, an emulsion, a spray, a cream, an essence or a mask.

[0025] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0026] (1) The present invention comprises an ionic liquid obtained by compounding ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid, and encapsulates the Centella asiatica extract therein, thereby effectively improving the stability, transdermal absorption rate and bioavailability of the Centella asiatica extract.

[0027] (2) The ingredients of the ionic liquid used in the present invention are all currently used ingredients in cosmetics, and will not introduce impurities to cause safety and compliance problems; at the same time, the superconducting Centella asiatica extract obtained by encapsulating the Centella asiatica extract with ionic liquid has obvious advantages in improving transdermal absorption rate, enhancing bioavailability, improving stability, reducing skin irritation, promoting penetration of the skin barrier, and providing sustained release. DETAILED DESCRIPTION

[0028] The present invention is further described in detail below by specific examples. The raw materials, reagents or devices used in the examples can be obtained from conventional commercial sources or by prior art methods unless otherwise specified. Unless otherwise specified, the experiments or test methods are conventional methods in the art.

[0029] Example 1

[0030] A superconducting Centella asiatica extract is prepared by a preparation method comprising the following steps:

[0031] (1) Ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid were mixed in a mass ratio of 5:1:1:2:1, and ultrasonic-assisted synthesis was performed at room temperature for 1 hour at a power of 300 W to form an ionic liquid;

[0032] (2) The Centella asiatica extract and the ionic liquid were mixed in a mass ratio of 1:10, heated to 40°C, and continuously stirred until completely dissolved, and then homogenized in a high-pressure homogenizer at 30 MPa and 40°C for 30 min to obtain a superconducting Centella asiatica extract.

[0033] Example 2

[0034] A superconducting Centella asiatica extract is prepared by a preparation method comprising the following steps:

[0035] (1) Ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid were mixed in a mass ratio of 4:1:2:2:1, and ultrasonic-assisted synthesis was performed at room temperature for 0.5 h at a power of 400 W to form an ionic liquid;

[0036] (2) The Centella asiatica extract and the ionic liquid were mixed in a mass ratio of 1:50, heated to 50°C, and continuously stirred until completely dissolved, and then homogenized in a high-pressure homogenizer at 10 MPa and 50°C for 60 minutes to obtain a superconducting Centella asiatica extract.

[0037] Example 3

[0038] A superconducting Centella asiatica extract is prepared by a preparation method comprising the following steps:

[0039] (1) Ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethanesulfonic acid were mixed in a mass ratio of 6:1:1:1.5:0.5, and ultrasonic-assisted synthesis was performed at room temperature for 1 h at a power of 500 W to form an ionic liquid;

[0040] (2) The Centella asiatica extract and the ionic liquid were mixed in a mass ratio of 1:100, heated to 70°C, and continuously stirred until completely dissolved, and then homogenized in a high-pressure homogenizer at 50 MPa and 30°C for 5 min to obtain a superconducting Centella asiatica extract.

[0041] Example 4

[0042] A superconducting Centella asiatica extract is prepared by a preparation method comprising the following steps:

[0043] (1) Ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethanesulfonic acid were mixed in a mass ratio of 4:3:1.5:1:0.5, and ultrasonic-assisted synthesis was performed at room temperature for 1 h at a power of 300 W to form an ionic liquid;

[0044] (2) The Centella asiatica extract and the ionic liquid were mixed in a mass ratio of 1:50, heated to 40°C, and stirred continuously until completely dissolved, and then homogenized in a high-pressure homogenizer at 30 MPa and 50°C for 30 min to obtain a superconducting Centella asiatica extract.

[0045] Example 5

[0046] A superconducting Centella asiatica extract is prepared by a preparation method comprising the following steps:

[0047] (1) Ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid were mixed in a mass ratio of 4:1:3:1:1, and ultrasonic-assisted synthesis was performed at room temperature for 1 hour at a power of 500 W to form an ionic liquid;

[0048] (2) The Centella asiatica extract and the ionic liquid were mixed in a mass ratio of 1:10, heated to 50°C, and continuously stirred until completely dissolved, and then homogenized in a high-pressure homogenizer at 10 MPa and 30°C for 45 minutes to obtain a superconducting Centella asiatica extract.

[0049] Example 6

[0050] A superconducting Centella asiatica extract is prepared by a preparation method comprising the following steps:

[0051] (1) Ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethanesulfonic acid were mixed in a mass ratio of 5:1.5:1:2:0.5, and ultrasonic-assisted synthesis was performed at room temperature for 1 hour at a power of 400 W to form an ionic liquid;

[0052] (2) The Centella asiatica extract and the ionic liquid were mixed in a mass ratio of 1:100, heated to 50°C, and continuously stirred until completely dissolved, and then homogenized in a high-pressure homogenizer at 50 MPa and 50°C for 30 minutes to obtain a superconducting Centella asiatica extract.

[0053] Comparative Example 1

[0054] The difference between Comparative Example 1 and Example 1 is that Comparative Example 1 does not contain urea, the mass ratio of ethoxydiglycol: betaine: N-ethylpyrrolidone: hydroxyethylpiperazineethane sulfonic acid is 6:1:2:1, and the other conditions are the same as Example 1.

[0055] Comparative Example 2

[0056] The difference between Comparative Example 2 and Example 1 is that in Comparative Example 2, an equal amount of urea is replaced by hydroxyethyl urea, and the other conditions are the same as those of Example 1.

[0057] Comparative Example 3

[0058] The difference between Comparative Example 3 and Example 1 is that Comparative Example 3 does not contain betaine, the mass ratio of ethoxydiglycol: urea: N-ethylpyrrolidone: hydroxyethylpiperazineethane sulfonic acid is 6:1:2:1, and the other conditions are the same as Example 1.

[0059] Comparative Example 4

[0060] The difference between Comparative Example 4 and Example 1 is that in Comparative Example 4, an equal amount of betaine is replaced by proline, and the other conditions are the same as those in Example 1.

[0061] Comparative Example 5

[0062] The difference between Comparative Example 5 and Example 1 is that Comparative Example 5 does not contain N-ethylpyrrolidone, the mass ratio of ethoxydiglycol: urea: betaine: hydroxyethylpiperazineethane sulfonic acid is 7:1:1:1, and the other conditions are the same as those in Example 1.

[0063] Comparative Example 6

[0064] The difference between Comparative Example 6 and Example 1 is that in Comparative Example 6, an equal amount of ethoxydiglycol is replaced by glycerol, and the other conditions are the same as those of Example 1.

[0065] Comparative Example 7

[0066] The difference between Comparative Example 7 and Example 1 is that in Comparative Example 7, an equal amount of hydroxyethylpiperazineethane sulfonic acid is replaced by levulinic acid, and the other conditions are the same as those of Example 1.

[0067] Comparative Example 8

[0068] The difference between Comparative Example 8 and Example 1 is that in Comparative Example 8, an equal amount of the ionic liquid is replaced by deionized water, and the other conditions are the same as those of Example 1.

[0069] Application Example 1

[0070] Application Example 1 provides an essence water containing the superconducting Centella asiatica extract of the present invention, and the specific formula is shown in Table 1.

[0071] Table 1

[0072]

[0073]

[0074] The method for preparing the essence water of Application Example 1 comprises the following steps:

[0075] (1) Heat the raw materials of phase A to 80°C, stir and disperse evenly, and set aside;

[0076] (2) Heat the raw materials of phase B to 65°C, stir and dissolve evenly, and set aside;

[0077] (3) pumping the phase B raw material of step (2) into the phase A of step (1) for homogenous stirring, stirring evenly and then cooling;

[0078] (3) After cooling to 45°C, add the raw materials of phase C and stir to disperse evenly to obtain essence water.

[0079] Application Example 2-6

[0080] The difference between Application Example 2-6 and Application Example 1 is that in Application Example 2-6, the superconducting Centella asiatica extract of Example 1 is replaced by the superconducting Centella asiatica extract of Example 2-6 respectively, and the other conditions are the same as those of Application Example 1.

[0081] Comparative Application Examples 1-8

[0082] The difference between Comparative Application Examples 1-8 and Application Example 1 is that in Comparative Application Examples 1-8, the superconducting Centella asiatica extract of Example 1 is replaced with the products prepared in Comparative Examples 1-8 respectively, and the other conditions are the same as those in Application Example 1.

[0083] Efficacy Test

[0084] Experimental Example 1: Permeability Test

[0085] The samples prepared in Examples 1-6 and Comparative Examples 1-8 were subjected to a transdermal test to test their permeability. The test method is as follows:

[0086] (1) Prepare the sample into a 50 mg / mL aqueous solution to ensure that the sample is dissolved evenly and completely;

[0087] (2) Process the pig skin sample into a thin slice with uniform thickness and no damage, remove the subcutaneous fat and connective tissue, rinse it with physiological saline and set aside;

[0088] (3) Fix the processed pig skin sample between the donor pool and the receptor pool of the Franz diffusion cell to ensure that the skin fits tightly to the diffusion cell without bubbles;

[0089] (4) Add an appropriate amount of PBS buffer to the receptor pool, turn on the constant temperature magnetic stirrer, maintain the temperature at 32°C-37°C to simulate human skin temperature, and continue stirring to ensure uniform drug concentration in the receiving medium;

[0090] (5) At 2 h, 4 h, 8 h, 12 h, and 24 h, a certain amount of receiving solution was taken out from the receptor pool, and an equal amount of fresh receiving medium was added. The concentration of Centella asiatica extract in the receiving solution was determined by HPLC and other analytical methods. The cumulative permeation amount, permeation rate and other parameters of the Centella asiatica extract were calculated according to the formula. The results are shown in Table 2.

[0091] Table 2

[0092]

[0093]

[0094] It can be seen from the experimental results in Table 2 that the cumulative amount and the rate of penetration of the Centella asiatica extract of Examples 1-6 are better than those of Comparative Examples 1-8. For example, the cumulative amount of Example 1 in 24 hours reaches 8.9858 mg / cm2 The transmission rate is stable at 0.3857mg / (cm 2 *h), significantly higher than 6.1840 mg / cm in Comparative Example 4 2 and 0.2669mg / (cm 2 *h). This indicates that the superconducting Centella asiatica extract of the present invention has good skin permeability.

[0095] Experimental Example 2 Hyaluronidase Inhibition Test

[0096] The samples prepared in Examples 1-6 and Comparative Examples 1-8 were subjected to a hyaluronidase inhibition test to evaluate their anti-allergic activity. The test method is as follows:

[0097] (1) Take four groups of clean test tubes, label them A, B, C, and D, add 0.5 mL of the sample to be tested to test tubes A and B, add 0.5 mL of distilled water to test tubes C and D, add 0.5 mL of 500 U / mL hyaluronidase solution to test tubes A and C, add 0.5 mL of pH 5.6 acetate buffer to test tubes B and D, and place the test tubes in a 37°C incubator for 20 min;

[0098] (2) Add 0.1 mL of 2.5 mol CaCl2 solution to each of the four test tubes and place them in a 37°C incubator for 20 min.

[0099] (3) Add 0.5 mL of 0.5 mg / mL sodium hyaluronate solution to test tubes A and C, and add 0.5 mL of pH 5.6 acetate buffer to test tubes B and D. Place the test tubes in a 37°C incubator for 30 min, then take them out and place them at room temperature for 5 min.

[0100] (4) Add 0.5 mL of distilled water, 0.1 mL of 5 mol NaOH solution, and 0.5 mL of acetylacetone solution to four test tubes respectively, place the test tubes in a boiling water bath for 15 min, then place them in an ice bath for 10 min, and finally place them at room temperature for 10 min;

[0101] (5) Add 1 mL of HRP-DAB reagent to each test tube, shake thoroughly, add anhydrous ethanol to 8 mL, leave at room temperature for 20 min, and then measure the absorbance at 530 nm using a spectrophotometer.

[0102] (6) Hyaluronidase inhibition rate (%) = [(CD) - (AB)] / (CD) × 100%;

[0103] Where: A is the OD value of the sample solution; B is the OD value of the sample blank; C is the OD value of the control sample solution; D is the OD value of the control sample blank;

[0104] The experimental results are shown in Table 3.

[0105] Table 3

[0106]

[0107]

[0108] It can be seen from the experimental results in Table 3 that the hyaluronidase inhibition rates of Examples 1-6 are similar to those of Comparative Examples 1-8, with no significant difference, indicating that the performance of the superconducting Centella asiatica extract encapsulated by ionic liquid in the present invention in inhibiting hyaluronidase activity is not affected by the ionic liquid and still has good activity.

[0109] Experimental Example 3 Skin Moisture Content and Transepidermal Water Loss (TEWL) Test

[0110] The moisture test uses the world-recognized CORNEOMETER-capacitance method. TEWL is a very important parameter for evaluating the function of the skin's moisture protection layer and has been widely recognized internationally. The more intact the skin's protection layer, the higher the moisture content and the lower the TEWL value. The skin moisture test can promptly detect whether the skin's barrier protection function has been damaged.

[0111] 3.1 Test Instrument

[0112] Corneometer test probe for skin moisture content manufactured by German Courage+Khazaka Company (German CK Company); TewameterTM300 test probe for transepidermal water loss (TEWL) manufactured by German Courage+Khazaka Company (German CK Company).

[0113] 3.2 Test Method

[0114] The samples prepared in Application Examples 1-6 and Comparative Application Examples 1-8 were subjected to the following experiments.

[0115] 420 people with dry skin (sensitive skin was screened according to the conventional lactic acid irritation score, and those with a cumulative lactic acid stinging sensation of ≥3 points were judged as sensitive skin) were selected, aged 20-45 years old, half male and half female. They were randomly divided into 14 groups, 30 volunteers in each group, half male and half female. No products (cosmetics, topical drugs, oral health products) could be used on the test area 15 days before. Before the test, the subjects were required to wash their faces and enter the climate-controlled room (22±1℃, relative humidity 50%) 2 hours after washing to sit quietly for more than 20 minutes and remain relaxed.

[0116] In the experiment, half of the face was tested according to a random table, with one side as a sample and the other side as a blank. The left and right nasolabial grooves of the volunteers were selected for skin moisture content and TEWL tests, and the average of the three values ​​was taken as the left and right nasolabial groove moisture content data (d0) and nasolabial groove TEWL data (d0). After the test, the volunteers were required to use it as required, with the application sample applied on one side of the face and the comparison application sample applied on the other side of the face. It was used continuously for 28 days, and the subjects were required to return on the 14th day (d14) and 28th day (d28) of the test.

[0117] 3.3 Test results

[0118] As shown in Table 4.

[0119] Table 4

[0120]

[0121]

[0122] It can be seen from the data in Table 4 that the essence water containing the superconducting Centella asiatica extract of the present invention has a better moisturizing effect on the skin than the essence water of the comparative application example. It can significantly increase the moisture content of the stratum corneum of the skin and reduce the moisture loss of the skin to the outside. It can be seen from the data that the moisturizing effect of adding the superconducting Centella asiatica extract of the present invention to cosmetics is significantly better than the moisturizing effect of the product of the comparative example, indicating that the superconducting Centella asiatica extract of the present invention has an excellent effect of repairing the skin barrier.

[0123] Experimental Example 4 Human Trial Evaluation Test

[0124] 4.1 Test methods

[0125] The samples prepared in Application Examples 1-6 and Comparative Application Examples 1-8 were evaluated in human trials. 420 healthy volunteers aged 20-45 years old were selected, half male and half female. They were randomly divided into 14 groups, with 15 males and 15 females in each group. Each group conducted a control test of the application examples and comparative application examples, with the samples used on the left side and the blank control on the right side. The samples were used once in the morning and evening every day for 30 days, and the skin color of the left and right faces was observed after one month of use.

[0126] During use, the samples were evaluated for mildness, barrier repair, skin elasticity, and hydration, with the highest score being 5 points and the lowest being 1 point.

[0127] 4.2 Test results

[0128] Fill in the trial evaluation form according to the sensory evaluation. Collect the trial evaluation form for the half-face test, and the statistical results are shown in Table 5.

[0129] Table 5

[0130]

[0131]

[0132] It can be seen from the results in Table 5 that, compared with comparative application examples 1-8, the essence water containing the superconducting Centella asiatica extract of application example 1-6 has obvious repairing effect on the skin. In addition, it also has good performance in skin elasticity and skin hydration, which can restore the skin to a healthy state, moisturized, silky, firm, full, and bright.

[0133] The preferred embodiments of the present invention are specifically described above, but the invention is not limited to the embodiments. Those skilled in the art may make various equivalent modifications or substitutions without violating the spirit of the invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A superconducting Centella asiatica extract, characterized in that: The superconducting Centella asiatica extract has a core-shell structure, wherein the core comprises the Centella asiatica extract, and the shell comprises an ionic liquid, wherein the ionic liquid comprises ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid.

2. The superconducting Centella asiatica extract according to claim 1, characterized in that The mass ratio of the ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethane sulfonic acid is (4-6): (1-3): (1-3): (1-2): (0.5-1).

3. The superconducting Centella asiatica extract according to claim 1, characterized in that The mass ratio of the Centella asiatica extract to the ionic liquid is 1:(10-100).

4. The method for preparing the superconducting Centella asiatica extract according to any one of claims 1 to 3, characterized in that: The following steps are involved: The ethoxydiglycol, urea, betaine, N-ethylpyrrolidone and hydroxyethylpiperazineethanesulfonic acid are mixed and ultrasonicated to obtain an ionic liquid; The Centella asiatica extract and the ionic liquid are mixed, heated and stirred, and homogenized under high pressure to obtain a superconducting Centella asiatica extract.

5. The preparation method according to claim 4, characterized in that: The power of the ultrasound is 300-500w; and / or, the time of the ultrasound is 0.5-2h; and / or, the ultrasound is performed at room temperature.

6. The preparation method according to claim 4, characterized in that: The temperature of the heating and stirring is 40-70°C.

7. The preparation method according to claim 4, characterized in that: The pressure of the high-pressure homogenization is 10-50 MPa; and / or, the temperature of the high-pressure homogenization is 30-50° C.; and / or, the time of the high-pressure homogenization is 5-60 min.

8. A cosmetic, characterized in that: The cosmetic comprises the superconducting Centella asiatica extract according to any one of claims 1 to 3.

9. The cosmetic according to claim 8, characterized in that: The content of the superconducting Centella asiatica extract is 0.01wt% to 1wt%.

10. The cosmetic according to claim 8, characterized in that: The dosage form of the cosmetic includes any one of an aqueous solution, an emulsion, a spray, a cream, an essence or a facial mask.

Images