Compound composition for treating alopecia and preparation method thereof
By developing a compound composition containing a variety of Chinese medicinal materials, and using hypertonic solution leaching and supercritical fluid extraction to extract effective ingredients, the existing hair loss treatment methods have limited effects, many side effects and expensive problems, and achieved safe, effective and economical hair loss treatment effects.
Patent Information
- Application Number
- CN202510016174.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-06
- Publication Date
- 2025-04-11
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing hair loss treatment methods have limited effects, many side effects, and expensive problems, which are difficult to meet people's demand for safe, effective and economical hair loss treatment products.
A compound composition for treating hair loss is developed, including mulberry seeds, Polygonatum, Rehmannia rehmannia, black sesame seeds, black beans, priveatum, polygonatum, wolfberry fruit, yam, Polygonatum, Astragalus, Peony, Ophiopogon japonicus, licorice and arborum, and the active ingredients are extracted through hypertonic solution extraction and supercritical fluid extraction to form a gentle and comfortable compound composition.
This compound composition effectively inhibits and reduces the amount of oil produced on the scalp, enhances the fluffy feeling of hair, reduces hair loss, and has a hair growth effect. It is gentle and comfortable in nature and has no adverse reactions.
Smart Images
Figure BDA0005229988240000071 
Figure BDA0005229988240000072 
Figure BDA0005229988240000081
Abstract
Description
Technical Field
[0001] The invention relates to the field of hair care daily chemicals, and in particular to a compound composition for treating hair loss and a preparation method thereof. Background Art
[0002] In modern life, the problem of hair loss has attracted increasing attention. Hair loss not only affects personal image, but may also be related to health problems. In order to solve the problem of hair loss, a variety of methods and products for treating hair loss have appeared on the market. However, these methods and products often have some shortcomings. Some traditional hair loss treatment methods mainly rely on a single ingredient or use drugs containing hormones. Although these methods can relieve the symptoms of hair loss to a certain extent, due to the single ingredient, the effect is often limited and there may be side effects. In addition, although some chemically synthesized anti-hair loss products have significant effects in the short term, long-term use may cause scalp allergies, dry hair and other problems, and may even have a negative impact on physical health. There are also some physical treatment methods, such as laser therapy and microneedle therapy, which can stimulate scalp blood circulation and promote hair growth, but these methods are often expensive and require long-term persistence, which is not realistic for ordinary consumers. In summary, the existing hair loss treatment methods have limited effects, many side effects, and high prices, which are difficult to meet people's needs for safe, effective and economical hair loss treatment products. Therefore, it is of great practical significance to develop a new, safe and effective hair loss treatment method. Summary of the invention
[0003] In view of this, the present invention develops a compound composition for treating hair loss to solve the above problems.
[0004] The technical solution of the present invention is achieved in this way:
[0005] A compound composition for treating hair loss comprises the following raw materials in parts by weight: 8-10 parts of mulberry seeds, 10-12 parts of Polygonum multiflorum, 12-15 parts of Rehmannia glutinosa, 8-10 parts of black sesame, 12-15 parts of black beans, 10-12 parts of Ligustrum lucidum fruits, 10-12 parts of Polygonatum sibiricum, 8-10 parts of wolfberry fruits, 6-8 parts of yam, 8-10 parts of Polygonatum odoratum, 10-12 parts of Astragalus, 6-8 parts of Paeonia lactiflora, 6-8 parts of Ophiopogon japonicus, 4-6 parts of Licorice, and 10-12 parts of Eclipta prostrata.
[0006] The method comprises the following preparation steps:
[0007] S1. Divide the raw materials into two parts. The first part is mulberry seeds, Polygonum multiflorum, Rehmannia glutinosa, black sesame, black bean, Ligustrum lucidum, Polygonatum sibiricum and Lycium barbarum fruit, which are mixed, dried and ground to obtain mixture I. The second part is Chinese yam, Polygonatum odoratum, Astragalus membranaceus, Paeonia lactiflora, Ophiopogon japonicus, Licorice and Eclipta prostrata, which are mixed, dried and ground to obtain mixture II.
[0008] S2, immersing the mixture I in a hypertonic solution to obtain an immersion solution;
[0009] S3, extracting and refluxing the soaking liquid, and concentrating it under reduced pressure to obtain extract I;
[0010] S4, extracting the mixture II by supercritical fluid extraction to obtain extract II;
[0011] S5. Pack extract I and extract II separately, and mix them before use to obtain the target compound composition.
[0012] Furthermore, in step S1, the drying temperature is 40-45° C., the drying time is 1-3 hours, and the grinding particle size is 150-200 mesh.
[0013] Further, in step S2, the hypertonic solution comprises proline, natural vitamin E and sodium chloride in a mass ratio of 20-30:5-7:4-6, and the soaking time is 30-40 minutes.
[0014] Furthermore, in step S2, the mass volume ratio of the mixture I and the hypertonic solution is 1 g:4-10 mL.
[0015] Furthermore, in step S3, the leaching and refluxing is performed with an ethanol solution having a concentration of 40-50%, and the reflux extraction is performed 2-3 times, each time for 0.5-1h; the reduced pressure concentration is performed with a temperature of 15-30°C, and the specific gravity of the extract is 1.10-1.14g / mL.
[0016] Further, in step S4, the supercritical fluid extraction method uses CO 2 As the extractant, the extraction pressure is 25-30MPa, the extraction temperature is 45-50°C, and the extraction time is 2-3h.
[0017] Further, in step S5, the mixing ratio is 1:0.4-0.6, and the mixing time is within 1-3 minutes before use.
[0018] Furthermore, a compound composition for treating hair loss comprises the following raw materials in parts by weight: 9 parts of mulberry seeds, 10 parts of Polygonum multiflorum, 12 parts of Rehmannia glutinosa, 10 parts of black sesame, 15 parts of black beans, 10 parts of Ligustrum lucidum fruits, 10 parts of Polygonatum sibiricum, 8 parts of wolfberry fruits, 6 parts of yam, 8 parts of Polygonatum odoratum, 10 parts of Astragalus, 8 parts of Paeonia lactiflora, 8 parts of Ophiopogon japonicus, 5 parts of Licorice, and 10 parts of Eclipta prostrata.
[0019] Compared with the prior art, the present invention has the following beneficial effects:
[0020] 1) The compound composition for treating hair loss prepared by using the raw materials of the present invention effectively inhibits and reduces the oil secretion of the scalp, and enhances the fluffy feeling of the hair;
[0021] 2) The extraction and mixing preparation method of the present invention increases the content of effective ingredients, reduces the amount of hair loss, and has a hair growth effect;
[0022] 3) The composition of the present invention is mild and comfortable, has no adverse reactions, and is suitable for promotion and application. DETAILED DESCRIPTION
[0023] In order to better understand the technical content of the present invention, specific examples are provided below to further illustrate the present invention. The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.
[0024] Unless otherwise specified, the materials, reagents, etc. used in the embodiments of the present invention can be obtained from commercial sources.
[0025] Example 1
[0026] A compound composition for treating hair loss comprises the following preparation steps:
[0027] Step (a): the raw materials are divided into two parts and dried and mixed separately. The first part is 8 parts of mulberry seeds, 10 parts of Polygonum multiflorum, 12 parts of Rehmannia glutinosa, 8 parts of black sesame, 12 parts of black beans, 10 parts of Ligustrum lucidum, 10 parts of Polygonatum sibiricum, and 8 parts of Lycium barbarum. The mixture is mixed and dried at a drying temperature of 40°C and a drying time of 1 hour. The mixture is ground after drying to a particle size of 150 mesh to obtain a first part of mixture I. The second part is 6 parts of yam, 8 parts of Polygonatum odoratum, 10 parts of Astragalus, 6 parts of Paeonia lactiflora, 6 parts of Ophiopogon japonicus, 4 parts of Licorice, and 10 parts of Eclipta prostrata. The mixture is mixed and dried at a drying temperature of 40°C and a drying time of 1 hour. The mixture is ground after drying to a particle size of 150 mesh to obtain a second part of mixture II.
[0028] Step (ii): Soaking the mixture I in a hypertonic solution, the hypertonic solution includes proline, natural vitamin E and sodium chloride in a mass ratio of 20:5:4, the mass volume ratio of the mixture I and the hypertonic solution is 1g:5mL, the immersion time of the mixture I in the hypertonic solution is 30min, and the immersion solution is obtained after immersion.
[0029] Step (iii): extract and reflux the soaking liquid, using 40% ethanol solution as the extracting liquid, reflux extraction twice, each time for 0.5h, and concentrate under reduced pressure after extraction, the concentration temperature is 15°C, the specific gravity of the extract after concentration is 1.1g / mL, and extract I is obtained.
[0030] Step (iv): extracting mixture II by supercritical fluid extraction, wherein the supercritical fluid extraction method uses CO 2 As the extractant, the extraction pressure is 25MPa, the extraction temperature is 45℃, the extraction time is 2h, and extract II is obtained.
[0031] Step (V): Extract I and Extract II are packaged separately and mixed before use at a mixing ratio of 1:0.4 for 1 minute before use to obtain the target compound composition.
[0032] Example 2
[0033] A compound composition for treating hair loss comprises the following preparation steps:
[0034] Step (a): the raw materials are divided into two parts and dried and mixed separately. The first part is 10 parts of mulberry seeds, 12 parts of Polygonum multiflorum, 15 parts of Rehmannia glutinosa, 10 parts of black sesame, 15 parts of black beans, 12 parts of Ligustrum lucidum, 12 parts of Polygonatum sibiricum, and 10 parts of Lycium barbarum. The mixture is mixed and dried at a drying temperature of 45°C and a drying time of 3 hours. The mixture is ground after drying to a particle size of 200 mesh to obtain a first part of mixture I. The second part is 8 parts of yam, 10 parts of Polygonatum odoratum, 12 parts of Astragalus, 8 parts of Paeonia lactiflora, 8 parts of Radix Ophiopogonis, 6 parts of Licorice, and 12 parts of Herba Ecliptae. The mixture is mixed and dried at a drying temperature of 45°C and a drying time of 3 hours. The mixture is ground after drying to a particle size of 200 mesh to obtain a second part of mixture II.
[0035] Step (ii): Soaking the mixture I in a hypertonic solution, the hypertonic solution includes proline, natural vitamin E and sodium chloride in a mass ratio of 30:7:6, the mass volume ratio of the mixture I and the hypertonic solution is 1g:10mL, the immersion time of the mixture I in the hypertonic solution is 40min, and the immersion solution is obtained after immersion.
[0036] Step (iii): extract and reflux the soaking liquid, using 50% ethanol solution as the extracting liquid, reflux extraction 3 times, each time for 1 hour, and concentrate under reduced pressure after extraction, the concentration temperature is 30°C, the specific gravity of the extract after concentration is 1.14g / mL, and extract I is obtained.
[0037] Step (iv): extracting mixture II by supercritical fluid extraction, wherein the supercritical fluid extraction method uses CO 2 As the extractant, the extraction pressure is 30MPa, the extraction temperature is 50℃, the extraction time is 3h, and extract II is obtained.
[0038] Step (V): Extract I and Extract II are packaged separately and mixed before use at a mixing ratio of 1:0.6 for 2 minutes before use to obtain the target compound composition.
[0039] Example 3
[0040] A compound composition for treating hair loss comprises the following preparation steps:
[0041] Step (a): the raw materials are divided into two parts and dried and mixed separately. The first part is 9 parts of mulberry seeds, 10 parts of Polygonum multiflorum, 13 parts of Rehmannia glutinosa, 10 parts of black sesame, 13 parts of black beans, 10 parts of Ligustrum lucidum, 10 parts of Polygonatum sibiricum, and 10 parts of Lycium barbarum. The mixture is mixed and dried at a drying temperature of 42° C. and a drying time of 2 hours. The mixture is ground after drying to a particle size of 200 mesh to obtain a first part of mixture I. The second part is 8 parts of yam, 10 parts of Polygonatum odoratum, 10 parts of Astragalus, 7 parts of Paeonia lactiflora, 7 parts of Ophiopogon japonicus, 5 parts of Licorice, and 10 parts of Eclipta prostrata. The mixture is mixed and dried at a drying temperature of 45° C. and a drying time of 2 hours. The mixture is ground after drying to a particle size of 200 mesh to obtain a second part of mixture II.
[0042] Step (ii): Soaking the mixture I in a hypertonic solution, wherein the hypertonic solution includes proline, natural vitamin E and sodium chloride in a mass ratio of 25:6:5, the mass volume ratio of the mixture I and the hypertonic solution is 1 g:7 mL, the immersion time of the mixture I in the hypertonic solution is 35 min, and an immersion solution is obtained after immersion.
[0043] Step (iii): extract and reflux the soaking liquid, using 45% ethanol solution as the extracting liquid, reflux extraction twice, each time for 1 hour, and concentrate under reduced pressure after extraction, the concentration temperature is 20°C, the specific gravity of the extract after concentration is 1.12g / mL, and extract I is obtained.
[0044] Step (iv): extracting mixture II by supercritical fluid extraction, wherein the supercritical fluid extraction method uses CO 2 As the extractant, the extraction pressure is 25MPa, the extraction temperature is 45℃, the extraction time is 2h, and extract II is obtained.
[0045] Step (V): Extract I and Extract II are packaged separately and mixed before use at a mixing ratio of 1:0.5 for 0.5 minutes before use to obtain the target compound composition.
[0046] Comparative Example 1
[0047] The difference from Example 3 is that in Comparative Example 1, the raw materials are not classified, all the raw materials are mixed and dried, and then extracted with a hypertonic solution.
[0048] Step (i): Mix and dry 9 parts of mulberry seeds, 10 parts of Polygonum multiflorum, 13 parts of Rehmannia glutinosa, 10 parts of black sesame, 13 parts of black beans, 10 parts of Ligustrum lucidum fruits, 10 parts of Polygonatum sibiricum, 10 parts of Lycium barbarum, 8 parts of Dioscorea opposita, 10 parts of Polygonatum odoratum, 10 parts of Astragalus, 7 parts of Paeonia lactiflora, 7 parts of Ophiopogon japonicus, 5 parts of Licorice, and 10 parts of Eclipta prostrata at a drying temperature of 45° C. for 2 hours, and grind after drying to a grinding particle size of 200 mesh to obtain a mixture.
[0049] Step (ii): soaking the mixture in a hypertonic solution, wherein the hypertonic solution includes proline, natural vitamin E and sodium chloride in a mass ratio of 25:6:5, the mass volume ratio of mixture I and the hypertonic solution is 1 g:7 mL, the soaking time of mixture I in the hypertonic solution is 35 min, and the soaking solution is obtained after soaking.
[0050] Step (iii): extracting and refluxing the soaking liquid, using 45% ethanol solution as the extracting liquid, reflux extraction twice, each time for 1 hour, and concentrating under reduced pressure after extraction, the concentration temperature is 20° C., the specific gravity of the extract after concentration is 1.12 g / mL, and the target compound composition is obtained.
[0051] Comparative Example 2
[0052] The difference from Example 3 is that in Comparative Example 2, the raw materials are not classified, all the raw materials are mixed and dried, and then extracted by supercritical fluid extraction.
[0053] Step (i): Mix and dry 9 parts of mulberry seeds, 10 parts of Polygonum multiflorum, 13 parts of Rehmannia glutinosa, 10 parts of black sesame, 13 parts of black beans, 10 parts of Ligustrum lucidum fruits, 10 parts of Polygonatum sibiricum, 10 parts of Lycium barbarum, 8 parts of Dioscorea opposita, 10 parts of Polygonatum odoratum, 10 parts of Astragalus, 7 parts of Paeonia lactiflora, 7 parts of Ophiopogon japonicus, 5 parts of Licorice, and 10 parts of Eclipta prostrata at a drying temperature of 45° C. for 2 hours, and grind after drying to a grinding particle size of 200 mesh to obtain a mixture.
[0054] Step (ii): extract the mixture by supercritical fluid extraction, using CO2 as the extractant, the extraction pressure is 25MPa, the extraction temperature is 45°C, and the extraction time is 2h to obtain the target compound composition.
[0055] Comparative Example 3
[0056] The difference from Example 3 is that the raw materials of Comparative Example 3 are removed from Eclipta prostrata, Polygonatum odoratum and Ligustrum lucidum, and other raw materials and preparation methods are the same as those of Example 3.
[0057] Comparative Example 4
[0058] The difference from Example 3 is that the step (ii) of "immersing mixture I in a hypertonic solution" in Comparative Example 4 is removed, and ethanol solution is directly used for extraction. Other raw materials and preparation methods are the same as those in Example 3.
[0059] Control: A commercially available topical liquid for preventing and treating hair loss, named Manongwu Hair Development Liquid, manufactured by Shenzhen Xinlidasheng Technology Co., Ltd.
[0060] test
[0061] Selection of volunteers for the test: 40 volunteers with hair loss aged 35-50 were selected. The number of hair strands that fell after shampooing was counted before the test, and the average of 5 times was calculated. Five test subjects of each embodiment, comparative example and control were tested for half a head. The test subject roughly divided the hair into two sides. After washing and drying the hair, one side was smeared with the test composition of the embodiment, comparative example and control, and evenly smeared on the entire scalp. The other side was only washed without smearing. The test subject smeared once every other day, for a total of 60 days and 30 times in total. The test sample was evaluated according to their own feelings, and the test results on the 30th and 60th days were recorded. Scoring criteria: (1) 9-10 points: very good, dandruff is refreshing, and there is no oil; (2) 7-8 points: good, the oil output is significantly less; (3) 5-6 points: average, the oil output is a little less than the other side; (4) 3-4 points: no difference; (5) 1-2 points: poor, the oil output is more than the other side. The average value of each group was calculated, and the statistical results are shown in Table 1.
[0062] The test results show that after 60 days of use, the amount of scalp oil secretion is significantly reduced by the compound composition for treating hair loss prepared by the method of Examples 1-3, which is higher than that of Comparative Examples 1-4 and the control. The subjects using Examples 1-3 can obviously feel a refreshed scalp and an increased fluffiness of the hair, indicating that the compound composition for treating hair loss prepared by the method of the present invention has a good scalp degreasing effect, and the degreasing effect of the present invention cannot be achieved by changing the raw material formula or the preparation method.
[0063] Table 1 Test score statistics (points)
[0064]
[0065] Compared with the beginning of the test, the amount of hair loss after 60 days of use of the composition for treating hair loss prepared by the method of Examples 1-3 was significantly reduced by 26.2%-30.3%, which was higher than that of Comparative Examples 1-3 and the control. This shows that the compound composition for treating hair loss prepared by the raw materials and preparation method of the present invention has an obvious application effect of treating hair loss.
[0066] Table 2 Statistics of hair loss reduction (%)
[0067]
[0068]
[0069] The scalp and hair follicle growth conditions of the subjects of Examples 1-3, Comparative Examples 1-4 and the control were observed by using a hair follicle detector. It was found that after applying the composite composition prepared by Examples 1-3, new hair follicles and hair were obviously observed on the 30th day, and the number of new hair follicles and hair increased on the 60th day. The hair growth effect of Comparative Examples 1-4 and the control was not obvious.
[0070] The test results are summarized. The present invention uses mulberry seeds, Polygonum multiflorum, Rehmannia glutinosa, black sesame, black bean, Ligustrum lucidum, Polygonatum sibiricum, Lycium barbarum, Chinese yam, Polygonatum odoratum, Astragalus, Paeonia lactiflora, Ophiopogon japonicus, Licorice, and Eclipta prostrata in combination, and adopts a separate mixed extraction method. The method of mixing again when using effectively reduces the amount of oil produced by the scalp, reduces the amount of hair loss, and has a hair growth effect. Comparative Examples 1 and 2 mixed all the raw materials and used the same method for extraction, but both failed to achieve the application effect of the present invention. Comparative Example 3 removed Eclipta prostrata, Polygonatum odoratum, and Ligustrum lucidum from the raw materials, and Comparative Example 4 removed the hypertonic solution dissolution step, and the degreasing and hair loss treatment effects of the composition were significantly reduced. Therefore, the Chinese medicine composition for treating hair loss prepared by the raw materials and methods of the present invention can effectively inhibit the formation of scalp oil, and has the application effect of treating hair loss and promoting hair growth.
[0071] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims
1. A compound composition for treating hair loss, characterized in that: The invention comprises the following raw materials in parts by weight: 8-10 parts of mulberry seeds, 10-12 parts of Polygonum multiflorum, 12-15 parts of Rehmannia glutinosa, 8-10 parts of black sesame, 12-15 parts of black beans, 10-12 parts of Ligustrum lucidum fruits, 10-12 parts of Polygonatum sibiricum, 8-10 parts of wolfberry fruits, 6-8 parts of yam, 8-10 parts of Polygonatum odoratum, 10-12 parts of Astragalus, 6-8 parts of Paeonia lactiflora, 6-8 parts of Ophiopogon japonicus, 4-6 parts of Licorice root and 10-12 parts of Eclipta prostrata.
2. A compound composition for treating hair loss according to claim 1, characterized in that: The method comprises the following preparation steps: S1. Divide the raw materials into two parts. The first part is mulberry seeds, Polygonum multiflorum, Rehmannia glutinosa, black sesame, black bean, Ligustrum lucidum, Polygonatum sibiricum and Lycium barbarum fruit, which are mixed, dried and ground to obtain mixture I. The second part is Chinese yam, Polygonatum odoratum, Astragalus membranaceus, Paeonia lactiflora, Ophiopogon japonicus, Licorice and Eclipta prostrata, which are mixed, dried and ground to obtain mixture II. S2, immersing the mixture I in a hypertonic solution to obtain an immersion solution; S3, extracting and refluxing the soaking liquid, and concentrating under reduced pressure to obtain extract I; S4, extracting the mixture II by supercritical fluid extraction to obtain extract II; S5. Pack extract I and extract II separately, and mix them before use to obtain the target compound composition.
3. A compound composition for treating hair loss according to claim 2, characterized in that: Step S1, the drying temperature is 40-45°C, the drying time is 1-3 hours, and the grinding particle size is 150-200 mesh.
4. A compound composition for treating hair loss according to claim 2, characterized in that: Step S2, the hypertonic solution comprises proline, natural vitamin E and sodium chloride in a mass ratio of 20-30:5-7:4-6, and the soaking time is 30-40 minutes.
5. A compound composition for treating hair loss according to claim 2, characterized in that: Step S2, the mass volume ratio of the mixture I and the hypertonic solution is 1g:4-10mL.
6. A compound composition for treating hair loss according to claim 2, characterized in that: Step S3, the extraction and reflux, the extracting solution is 40-50% ethanol solution, reflux extraction 2-3 times, each time 0.5-1h; the reduced pressure concentration, the temperature is 15-30°C, the extract specific gravity is 1.10-1.14g / mL.
7. A compound composition for treating hair loss according to claim 2, characterized in that: Step S4, the supercritical fluid extraction method uses CO2 as the extraction agent, the extraction pressure is 25-30MPa, the extraction temperature is 45-50°C, and the extraction time is 2-3h.
8. A compound composition for treating hair loss according to claim 2, characterized in that: Step S5, the mixing ratio is 1:0.4-0.6, and the mixing time is within 1-3 minutes before use.
9. A compound composition for treating hair loss according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 9 parts of mulberry seeds, 10 parts of Polygonum multiflorum, 12 parts of Rehmannia glutinosa, 10 parts of black sesame, 15 parts of black beans, 10 parts of Ligustrum lucidum fruits, 10 parts of Polygonatum sibiricum, 8 parts of wolfberry fruits, 6 parts of yam, 8 parts of Polygonatum odoratum, 10 parts of Astragalus, 8 parts of Paeonia lactiflora, 8 parts of Ophiopogon japonicus, 5 parts of Licorice root and 10 parts of Eclipta prostrata.